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1.
J Neuroophthalmol ; 28(3): 239-40, 2008 Sep.
Artículo en Inglés | MEDLINE | ID: mdl-18769295
4.
Neuroreport ; 5(11): 1333-6, 1994 Jun 27.
Artículo en Inglés | MEDLINE | ID: mdl-7919192

RESUMEN

Spontaneous eye movements were recorded before and after a microinjection (0.1-0.2 microliter) of either APV (an NMDA receptor antagonist) or NBQX (a non-NMDA receptor antagonist) into the nucleus prepositus hypoglossi (NPH) of the alert cat. A unilateral injection of APV caused bilateral failure of the horizontal gaze-holding system: in the light, each saccade was followed by a post-saccadic drift. A unilateral injection of NBQX caused no sign of gaze-holding failure; in the light, spontaneous eye movements were unaffected; in complete darkness, a nystagmus with linear slow phases directed towards the injected side was observed. We conclude that NMDA receptors of the NPH neurones are involved in the gaze-holding system.


Asunto(s)
2-Amino-5-fosfonovalerato/farmacología , Nervio Oculomotor/microbiología , Quinoxalinas/farmacología , Receptores de N-Metil-D-Aspartato/efectos de los fármacos , Animales , Gatos , Oscuridad , Movimientos Oculares/fisiología
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