RESUMEN
Drop in 21st Century Cures Act funding will slow BRAIN and All of Us projects.
Asunto(s)
Medicina Genómica , National Institutes of Health (U.S.) , Neurociencias , Apoyo a la Investigación como Asunto , Humanos , Financiación Gubernamental , National Institutes of Health (U.S.)/economía , Estados Unidos , Neurociencias/economía , Medicina Genómica/economíaAsunto(s)
Atlas como Asunto , Encéfalo , Neurociencias , Encéfalo/citología , Humanos , Neurociencias/economía , Neurociencias/tendenciasRESUMEN
The $746 million program builds on the country's strengths in neuroscience-and its openness to primate research.
Asunto(s)
Encéfalo , Haplorrinos , Neurociencias , Experimentación Animal , Animales , China , Cooperación Internacional , Neurociencias/economía , Neurociencias/tendenciasRESUMEN
The Cre/LoxP-based conditional knockout technology is a powerful tool for gene function analysis that allows region- and time-specific gene manipulation. However, inserting a pair of LoxP cassettes to generate conditional knockout can be technically challenging and thus time- and resource-consuming. This study proposes an efficient, low-cost method to generate floxed mice using in vitro fertilization and the CRISPR-Cas9 system over two consecutive generations. This method allowed us to produce floxed mice targeting exons 5 and 6 of CaMK1 in a short period of 125 days, using only 16 mice. In addition, we directly edited the genome of fertilized eggs of mice with our target genetic background, C57BL/6 N, to eliminate additional backcrossing steps. We confirmed that the genome of the generated floxed mice was responsive to the Cre protein. This low-cost, time-saving method for generating conditional knockout will facilitate comprehensive, tissue-specific genome analyses.
Asunto(s)
Sistemas CRISPR-Cas , Electroporación/métodos , Edición Génica/métodos , Marcación de Gen/métodos , Ratones Noqueados , Neurociencias/métodos , Animales , Secuencia de Bases , Proteína Quinasa Tipo 1 Dependiente de Calcio Calmodulina/genética , Transferencia de Embrión , Exones/genética , Edición Génica/economía , Marcación de Gen/economía , Integrasas , Ratones , Ratones Endogámicos C57BL , Neurociencias/economía , TransgenesRESUMEN
Neuroscience research in Africa remains sparse. Devising new policies to boost Africa's neuroscience landscape is imperative, but these must be based on accurate data on research outputs which is largely lacking. Such data must reflect the heterogeneity of research environments across the continent's 54 countries. Here, we analyse neuroscience publications affiliated with African institutions between 1996 and 2017. Of 12,326 PubMed indexed publications, 5,219 show clear evidence that the work was performed in Africa and led by African-based researchers - on average ~5 per country and year. From here, we extract information on journals and citations, funding, international coauthorships and techniques used. For reference, we also extract the same metrics from 220 randomly selected publications each from the UK, USA, Australia, Japan and Brazil. Our dataset provides insights into the current state of African neuroscience research in a global context.
Asunto(s)
Neurociencias/tendencias , Publicaciones/tendencias , África , Autoria , Internacionalidad , Factor de Impacto de la Revista , Neurociencias/economía , Apoyo a la Investigación como Asunto/economíaRESUMEN
Brains are indispensable drivers of human progress. Why not invest more heavily in them? We seek to place Brain Capital at the center of a new narrative to fuel economic and societal recovery and resilience.
Asunto(s)
Encéfalo , Financiación del Capital , Promoción de la Salud , Investigación Interdisciplinaria , Neurociencias , Investigación Biomédica/economía , Promoción de la Salud/economía , Promoción de la Salud/métodos , Promoción de la Salud/organización & administración , Humanos , Comunicación Interdisciplinaria , Investigación Interdisciplinaria/economía , Investigación Interdisciplinaria/organización & administración , Neurociencias/economíaAsunto(s)
Enfermedades del Sistema Nervioso/economía , Neurología/economía , Neurología/tendencias , Neurociencias/economía , Neurociencias/tendencias , Investigación Biomédica , Europa (Continente) , Humanos , Enfermedades del Sistema Nervioso/epidemiología , Enfermedades del Sistema Nervioso/terapiaRESUMEN
BACKGROUND: Admission to a neuroscience intensive care unit (Neuro-ICU) is sudden and often traumatic for both patients and their informal caregivers. No prior studies have assessed prospectively risk and resiliency factors for chronic posttraumatic symptoms, as well as the potential interdependence between patients' and caregivers' symptoms over time. OBJECTIVE: To analyze the impact of baseline resiliency factors on symptoms of posttraumatic stress (PTS) longitudinally in dyads of patients admitted to the Neuro-ICU and their primary family caregivers. METHODS: We recruited dyads (M = 108) of patients admitted to the Neuro-ICU (total N = 102) and their family caregivers (total N = 103). Dyads completed self-report assessments of PTS and resiliency factors (mindfulness and coping) at baseline in the Neuro-ICU. PTS was measured again at 3- and 6-month follow-up. RESULTS: Clinically significant PTS symptoms were high at baseline in both patients (20%) and caregivers (16%) and remained high through 6 months (25% in patients; 14% in caregivers). Actor-partner interdependence modeling demonstrated that severity of PTS symptoms was predictive of PTS symptoms at subsequent time points (P < 0.001). High baseline mindfulness and coping predicted less severe PTS symptoms in patients and caregivers (P < 0.001) at all time points. Own degree of PTS symptoms at 3 months predicted worse PTS symptoms in one's partner at 6 months, for both patients and caregivers (P = 0.02). CONCLUSIONS: Findings highlight the need to prioritize assessment and treatment of PTS in Neuro-ICU patients and their informal caregivers through a dyadic approach.
Asunto(s)
Cuidadores/psicología , Unidades de Cuidados Intensivos , Neoplasias/psicología , Neurociencias , Resiliencia Psicológica , Trastornos por Estrés Postraumático/diagnóstico , Adaptación Psicológica , Instituciones Oncológicas/economía , Estudios de Cohortes , Comorbilidad , Relaciones Familiares , Costos de la Atención en Salud/estadística & datos numéricos , Humanos , Unidades de Cuidados Intensivos/economía , Atención Plena , Neoplasias/economía , Neurociencias/economía , Estudios Prospectivos , Rehabilitación Psiquiátrica , Calidad de Vida/psicología , Estudios Retrospectivos , Factores de Riesgo , Trastornos por Estrés Postraumático/economía , Trastornos por Estrés Postraumático/psicología , Estados UnidosRESUMEN
BACKGROUND: Neurologic disorders impose a heavy burden on healthcare in Singapore. To date, no data on the willingness to pay (WTP) for neurologic treatments has been reported in the local population. OBJECTIVES: We aimed to quantify the value of various health domains to neuroscience patients and their caregivers by comparing their WTP for different types of treatments. METHODS: A questionnaire using a mixed open-ended and closed-ended contingent valuation method was developed to elicit WTP and self-administered by 112 visitors to a neuroscience outpatient clinic. The WTP for treatments in 3 health domains (advanced restoration of function, life extension, and cosmesis) was evaluated and compared. Subgroup regression analysis was performed to investigate the impact of demographic and socioeconomic factors. RESULTS: Treatment that improved cosmesis had the highest median WTP of Singapore dollar (SGD) 35 000, followed by treatment that provided 1 year of life extension (SGD 20 000) and 1 year of advanced restored function (SGD 10 000; P < .001). Respondents with a university education were willing to pay as much as 2 to 3 times of those without across all health domains. CONCLUSION: This is the first study to provide data on how different health domains are valued by neuroscience patients and caregivers in our population. Respondents valued treatment that restored or improved their physical appearances the most. These findings could contribute to future policies on the improvement of neuroscience care.
Asunto(s)
Instituciones de Atención Ambulatoria/estadística & datos numéricos , Cuidadores/psicología , Neurociencias/métodos , Pacientes/psicología , Recuperación de la Función/fisiología , Adulto , Instituciones de Atención Ambulatoria/economía , Instituciones de Atención Ambulatoria/organización & administración , Cuidadores/estadística & datos numéricos , Análisis Costo-Beneficio , Femenino , Humanos , Masculino , Persona de Mediana Edad , Neurociencias/economía , Neurociencias/tendencias , Pacientes/estadística & datos numéricos , Años de Vida Ajustados por Calidad de Vida , Singapur , Factores Socioeconómicos , Estadísticas no Paramétricas , Encuestas y CuestionariosAsunto(s)
Encéfalo/fisiología , Encéfalo/fisiopatología , Neurociencias/organización & administración , Neurociencias/tendencias , Investigación Biomédica/economía , Investigación Biomédica/organización & administración , Investigación Biomédica/tendencias , Unión Europea/economía , Humanos , Japón , Neurociencias/economía , Estados UnidosRESUMEN
Improving the reproducibility of neuroscience research is of great concern, especially to early-career researchers (ECRs). Here I outline the potential costs for ECRs in adopting practices to improve reproducibility. I highlight the ways in which ECRs can achieve their career goals while doing better science and the need for established researchers to support them in these efforts.
Asunto(s)
Investigación Biomédica/normas , Neurociencias/normas , Investigadores/normas , Investigación Biomédica/economía , Humanos , Neurociencias/economía , Reproducibilidad de los Resultados , Investigadores/economíaAsunto(s)
Academias e Institutos/organización & administración , Derechos del Animal/legislación & jurisprudencia , Disentimientos y Disputas , Neurociencias/legislación & jurisprudencia , Investigadores/legislación & jurisprudencia , Sociedades Científicas/organización & administración , Academias e Institutos/economía , Animales , Animales de Laboratorio , Alemania , Liderazgo , Neurociencias/economía , Neurociencias/métodos , Primates , Investigadores/psicología , Sociedades Científicas/economíaAsunto(s)
Neurociencias , Animales , China , Humanos , Neurociencias/economía , Neurociencias/educaciónRESUMEN
Neuroscience research and training in many African countries are difficult due to funding and infrastructure deficit. This has resulted in few neuroscientists within Africa. However, invertebrates such as Drosophila and Caenorhabditis elegans could provide the perfect answer to these difficulties. These organisms are cheap, easy to handle and offer a comparable advantage over vertebrates in neuroscience research modeling because they have a simple nervous system and exhibit well-defined behaviors. Studies using invertebrates have helped to understand neurosciences and the complexes associated with it. If Africa wants to catch up with the rest of the world in neuroscience research, it needs to employ this innovative cost-effective approach in its research. To improve invertebrate neuroscience within the Africa continent, the authors advocated the establishment of invertebrate research centers either at regional or national level across Africa. Finally, there is also a need to provide public funding to consolidate the gains that have been made by not-for-profit international organizations over the years.