RESUMEN
Lymphomatoid papulosis is a benign self-healing condition, presenting as papulonodular skin eruptions and mimicking malignant cutaneous lymphomas histopathologically. F-FDG PET/CT findings in this benign condition have not been described in detail in the literature. We present a case of lymphomatoid papulosis mimicking primary cutaneous anaplastic large cell lymphoma histopathologically and demonstrating intensely FDG-avid cutaneous lesions on F-FDG PET/CT, which disappear spontaneously in the follow-up scan.
Asunto(s)
Fluorodesoxiglucosa F18 , Linfoma Anaplásico Cutáneo Primario de Células Grandes/diagnóstico por imagen , Papulosis Linfomatoide/diagnóstico por imagen , Tomografía Computarizada por Tomografía de Emisión de Positrones , Neoplasias Cutáneas/diagnóstico por imagen , Adulto , Diagnóstico Diferencial , Femenino , HumanosRESUMEN
Primary cutaneous lymphomas are a heterogeneous group that includes 2 main groups of primary T- and B-cell lymphomas, which can involve the skin with distinct variability in clinical presentation, histopathology, immunophenotypes, molecular signature, and prognosis. The authors describe the most frequent clinical forms of cutaneous lymphomas and their dermoscopic features. Even if the diagnosis of these entities is still based on a cellular level and the literature on dermoscopy in cutaneous lymphomas is limited and, for several entities it is based only on single case reports/case series, we think that know how they appear also in dermoscopy can be useful for helping in the clinical diagnosis.
Asunto(s)
Dermoscopía , Linfoma de Células B/diagnóstico por imagen , Linfoma Cutáneo de Células T/diagnóstico por imagen , Seudolinfoma/diagnóstico por imagen , Humanos , Linfoma de Células B de la Zona Marginal/diagnóstico por imagen , Linfoma Folicular/diagnóstico por imagen , Linfoma de Células B Grandes Difuso/diagnóstico por imagen , Linfoma Anaplásico Cutáneo Primario de Células Grandes/diagnóstico por imagen , Papulosis Linfomatoide/diagnóstico por imagen , Micosis Fungoide/diagnóstico por imagen , Síndrome de Sézary/diagnóstico por imagenRESUMEN
Lymphomatoid papulosis (LP) is a rare low-grade T-cell lymphoma which may respond to cytotoxic drugs and PUVA irradiation but long-term remission has not been achieved. Extracorporeal photochemotherapy (ECP) is an immunomodulating therapy used successfully for several types of CTCL, no experience with LP has been reported yet. ECP therapy with 8-methoxypsoralen was introduced on two subsequent days once per month for half a year in a 42-year old women with a 20-year history of LP. Disseminated papules disappeared rapidly after 3 cycles of ECP treatment but metastatic spread continued, which made necessary a subsequent polychemotherapy. One year later, the patient died of central nervous system metastasis. ECP monotherapy seems unable to control disease progression in LP despite beneficial effects on skin lesions.
