From emigration to remigration: The Jewish pathologist Fritz Meyer (1875-1953) and his extraordinary life course.

Fritz Meyer (1875-1953) is undoubtedly one of the most enigmatic pathologists and internists of his time: He emerged early as a major researcher in the field of infectious diseases. Later, he also focused on heart and lung diseases and became a celebrity doctor who treated ambassadors and prominent contemporaries of the United States. The course of his life was as unusual as his professional activities: At the beginning of the Third Reich, Meyer experienced far-reaching repression due to his Jewish ancestry, which led to forced emigration to the USA. Although he achieved professional success in his new homeland, he returned to Germany in 1948 - as one of very few Jewish emigrants from the Third Reich. This article takes these peculiarities as an opportunity to take a closer look at Fritz Meyer: It recapitulates the biography and scientific merits of the Jewish pathologist and pays special attention to the background of his emigration to the USA and his later remigration to Germany. The central basis of the study are contemporary newspaper articles and various archival sources evaluated for the first time. These sources are compared with the sparse secondary literature on Meyer and other persecuted pathologists. The results of the study can be summarized in five points: (1) Meyer's research on infectious diseases - especially diphtheria, tuberculosis and serum therapy - was considered leading-edge at the time. (2) Meyer suffered widespread repression after 1933, which led him to emigrate to the United States in 1935. (3) Thanks to influential contacts, he was able to continue his professional career in the U.S. almost seamlessly. (4) In the postwar period, he decided to return to Germany, mainly out of attachment to Europe. (5) His reintegration in Germany seemed to be successful - however, he died only a few years after his remigration. The analysis leads to the conclusion that Meyer's social reintegration in postwar Germany was significantly facilitated by his professional reputation and his largely apolitical demeanor in public; nevertheless, it can be shown that he secretly lamented the lack of consciousness of guilt of the German postwar population. Several indications cast doubt on his intention to remain permanently in Germany. This includes the fact that he held on to his U.S. citizenship until the end of his life and that his wife remained in the United States.

Aldred Scott Warthin: Ann Arbor's Erudite, Outspoken, and Academically Transformative Early 20th Century Pathologist.

CONTEXT.­: Aldred Scott Warthin, MD, PhD, was professor of pathology and director of the pathological laboratory at the University of Michigan during the first third of the 20th century. OBJECTIVE.­: To explore the life and accomplishments of Dr. Warthin and his impact on academic anatomic and clinical pathology. DESIGN.­: Available primary and secondary historic sources were reviewed. RESULTS.­: After studying music, biology, and botany, Warthin attended medical school at the University of Michigan, graduating in 1891; he remained in Ann Arbor for 40 years, almost single-handedly transforming a rundown department into a top academic department. He was a dedicated teacher who produced 2 important pathology textbooks. His research interests were diverse. In 1913, he published one of the first papers unambiguously documenting heritability of cancers; subsequent research on one of his cancer families resulted in the description of Lynch Syndrome. He published extensively in the fields of surgical pathology and experimental pathology. He was a recognized expert on syphilis and pathology of aging. CONCLUSIONS.­: Warthin's name is eponymously associated with Warthin-Finkeldey giant cells in measles, Warthin's tumor of the parotid, and Warthin-Starry stain for the diagnosis of syphilis as well as Warthin's sign in the clinical diagnosis of pericarditis.

Historical perspectives in clinical pathology: Bence Jones protein-early urine chemistry and the impact on modern day diagnostics.

This is the third in the series of historical articles dealing with developments in clinical pathology. Bence Jones proteins are immunoglobulin light chains found in excessive quantities in urine in multiple myeloma and are believed to be one of the first tumour markers ever discovered . Dr Henry Bence Jones is credited with the discovery of this protein in 1847 that bears his name and he can also be regarded as the first chemical pathologist/clinical chemist. Since then, numerous advances and refinements have been made in the measurement and detection of urine light chain proteins which have resulted in the current sensitive serum free light chain assays used today.

Fifty years of impact on liver pathology: a history of the Gnomes.

Professional societies play a major role in medicine and science. The societies tend to be large with well-developed administrative structures. An additional model, however, is based on small groups of experts who meet regularly in an egalitarian model in order to discuss disease-specific scientific and medical problems. In order to illustrate the effectiveness of this model, the history and practices are examined of a long-standing successful example, the International Liver Pathology Group, better known as the Gnomes. The history shows that groups such as the Gnomes offer a number of important benefits not available in larger societies and nurturing such groups advances science and medicine in meaningful ways. The success of the Gnomes' approach provides a road map for future small scientific groups.

Carl von Rokitansky, el Linneo de la anatomía patológica / Carl von Rokitansky, the Linné of pathological anatomy

Resumen Carl von Rokitansky fue una de las figuras más importantes en la anatomía patológica y el responsable, en parte, del renacimiento de Viena como centro de la medicina a mediados del siglo XIX. Nació en la actual Hradec Králové, estudió medicina en Praga y Viena y se graduó en 1828. Tuvo gran influencia de los estudios de anatomía, embriología y patología de Andral, Lobstein y Meckel. En la escuela de Viena fue asistente de anatomía patológica de Johann Wagner y se convirtió en profesor de anatomía patológica, donde permaneció hasta cuatro años antes de su muerte. Rokitansky hizo énfasis en correlacionar la sintomatología del enfermo con los cambios post mortem. Es posible que haya tenido acceso a entre 1500 y 1800 cadáveres al año para que pudiera realizar 30 000 necropsias; además, revisó varios miles más de autopsias. En Handbuch der Pathologischen Anatomie, publicado entre 1842 y 1846, realizó numerosas descripciones: de la neumonía lobular y lobular, endocarditis, enfermedades de las arterias, quistes en varias vísceras, diversas neoplasias y de la atrofia aguda amarilla del hígado. Con su brillante labor de patología macroscópica, Rokitansky estableció la clasificación nosológica de las enfermedades, por lo cual Virchow lo llamó “el Linneo de la anatomía patológica”.

Abstract Carl von Rokitansky was one of the most important figures in pathological anatomy, and was largely responsible for the resurgence of Vienna as the great medical center of the world in the mid-19th century. He was born in current Hradec Králové, studied medicine in Prague and Vienna and was graduated in 1828. He was greatly influenced by the anatomy, embryology and pathology studies of Andral, Lobstein and Meckel. At the Vienna School, he was Johann Wagner pathological anatomy assistant and became a pathology professor, where he remained until four years before his death. Rokitansky emphasized the importance of correlating patient symptoms with postmortem changes. It is possible that he had access to between 1,500 and 1,800 cadavers annually to be able to perform 30,000 necropsies; in addition, he reviewed several thousand more autopsies. In Handbuch der pathologischen Anatomie, published between 1842 and 1846, he made numerous descriptions: lobar and lobular pneumonia, endocarditis, diseases of the arteries, cysts in several viscera, various neoplasms and acute yellow atrophy of the liver. With his brilliant work on gross pathology, Rokitansky established the nosological classification of diseases, for which Virchow named him “the Linné of pathological anatomy”.

Albert C. Broders, tumor grading, and the origin of the long road to personalized cancer care.

The roots of precision cancer therapy began at the Mayo Clinic in 1914 when surgical pathologist Albert C. Broders began collecting data showing that cancers of the same histologic type behaved differently. In March 1920, based upon 6 years of clinical follow-up, Broders published his first paper, utilizing data from over 500 cases of squamous cell carcinoma of the lip that he had blindly divided into four histologic grades based upon degree of differentiation, showing that numerical tumor "grading" allowed him to predict patient prognosis. Before this, surgeons had no scientific way to evaluate prognosis. Broders then replicated his work using other types of tumors at other body sites, as did several Mayo Fellows and pathologists at other institutions. Cuthbert Dukes in London, England not only replicated Broders' findings with rectal adenocarcinomas, he also used the same data to develop the first tumor "staging" methodology by focusing upon depth of local invasion and presence or absence of lymph node metastases. Soon, tumor grading, tumor staging, or the combination of both represented state-of-the-art prognostic techniques for scientific cancer care. This brief historical vignette celebrates the 100th anniversary of Broders' first paper, which is the starting point for the long road to personalized cancer care.

A fairytale career in spite of political disenfranchisement: The jewish oral pathologist Bálint Orbán (1899-1960).

Viennese scientist Bálint Orbán (1899-1960) was an international pioneer in the area of oral pathology and one of the principle figures comprising the "Vienna School" of the 1920s. His works "Biology and Pathology of the Tooth and its Supporting Mechanism" (1938) and "Atlas of Clinical Pathology of the Oral Mucous Membrane" (1955), both published in the United States, set new standards across the globe. Even today, the American Academy of Periodontology (AAP) honors aspiring researchers with the Bálint Orbán Award in the context of its "Orbán Memorial Program". One aspect of Orbán's life that remains widely unknown is the fact that his career was thrown into existential threat following Hitler's rise to power in 1938. As a scientist of Jewish ancestry, the new government stripped him of his venia legendi and, as such, robbed him the basis for working as a university professor in Vienna. What became of Orbán's life and career in the years thereafter? What were the conditions that ultimately led him to the United States? How did he manage to set up his career in this new context - including in comparison to his other colleagues who also emigrated? Which factors were ultimately decisive for his further career? The present article seeks to address these very questions. The sources used for this study include documents from the Austrian State Archives as well as from the Vienna University Archive. Our archival work was followed by a critical re-analysis of the available secondary literature. This article illustrates that Bálint Orbán was part of a small group of Jewish scientists who did not suffer from a rupture or setback in their careers under National Socialism. In fact, despite professional disenfranchisement and forced migration, they succeeded in making smooth professional transitions and even advancing their careers. One decisive factor in this - apart from Orbán's consistently high-degree of dedication to his work and above-average research output - was his robust network academic contacts, which he previously laid the groundwork for during his first stay in the United States (1927-1929) and continued to resolutely foster afterwards. Thanks to these contacts, even before his permission to work as a professor in Vienna was revoked, Orbán managed to flee to Chicago and quickly attain a professorship. He spent the rest of his academic life in the United States and, much like his other émigré colleague from Vienna, Hans Popper (1903-1988), he developed what would become his posthumous prominence in this new country.

Philip T. Cagle, MD-Editor-in-Chief of the Archives of Pathology & Laboratory Medicine, 2005-2019.

• The Archives of Pathology & Laboratory Medicine was first published in 1926 as a specialty journal of the American Medical Association. It became the official journal of the College of American Pathologists in 1995. Under the dynamic leadership of its most recent editor-in-chief, Philip T. Cagle, MD, the Archives has dramatically increased its impact factor and become the most widely read general pathology journal. Dr. Cagle has consistently added leading pathologists to the editorial board, and the collective expertise of these individuals is clearly evident in new, cutting-edge journal masthead sections. The Archives has featured innovative content in the field of digital pathology, including articles on the utilization of smart phones in pathology and the incorporation of whole-slide images and videos into the content of articles. During the current editorial board's tenure, special sections were introduced and have proven immensely popular with the journal's readership. As the Archives celebrates its 94th anniversary, its editorial board remains committed to providing insightful and relevant medical knowledge. The journal's open access Web site ( www.archivesofpathology.org ) allows the dissemination of this information to every corner of the globe at no expense to those who wish to expand their knowledge or improve their medical practice. Dr. Cagle, with support from the editorial board and journal staff, has worked tirelessly during his tenure as Archives editor-in-chief to greatly enhance the content of the journal and its stature within pathology and laboratory medicine.

Carl von Rokitansky, the Linné of pathological anatomy.

Carl von Rokitansky was one of the most important figures in pathological anatomy, and was largely responsible for the resurgence of Vienna as the great medical center of the world in the mid-19th century. He was born in current Hradec Králové, studied medicine in Prague and Vienna and was graduated in 1828. He was greatly influenced by the anatomy, embryology and pathology studies of Andral, Lobstein and Meckel. At the Vienna School, he was Johann Wagner pathological anatomy assistant and became a pathology professor, where he remained until four years before his death. Rokitansky emphasized the importance of correlating patient symptoms with postmortem changes. It is possible that he had access to between 1,500 and 1,800 cadavers annually to be able to perform 30,000 necropsies; in addition, he reviewed several thousand more autopsies. In Handbuch der pathologischen Anatomie, published between 1842 and 1846, he made numerous descriptions: lobar and lobular pneumonia, endocarditis, diseases of the arteries, cysts in several viscera, various neoplasms and acute yellow atrophy of the liver. With his brilliant work on gross pathology, Rokitansky established the nosological classification of diseases, for which Virchow named him "the Lineé of pathological anatomy".Carl von Rokitansky fue una de las figuras más importantes en la anatomía patológica y el responsable, en parte, del renacimiento de Viena como centro de la medicina a mediados del siglo XIX. Nació en la actual Hradec Králové, estudió medicina en Praga y Viena y se graduó en 1828. Tuvo gran influencia de los estudios de anatomía, embriología y patología de Andral, Lobstein y Meckel. En la escuela de Viena fue asistente de anatomía patológica de Johann Wagner y se convirtió en profesor de anatomía patológica, donde permaneció hasta cuatro años antes de su muerte. Rokitansky hizo énfasis en correlacionar la sintomatología del enfermo con los cambios post mortem. Es posible que haya tenido acceso a entre 1500 y 1800 cadáveres al año para que pudiera realizar 30 000 necropsias; además, revisó varios miles más de autopsias. En Handbuch der Pathologischen Anatomie, publicado entre 1842 y 1846, realizó numerosas descripciones: de la neumonía lobular y lobular, endocarditis, enfermedades de las arterias, quistes en varias vísceras, diversas neoplasias y de la atrofia aguda amarilla del hígado. Con su brillante labor de patología macroscópica, Rokitansky estableció la clasificación nosológica de las enfermedades, por lo cual Virchow lo llamó "el Linneo de la anatomía patológica".

Kurt Benirschke, MD (1924-2018): Pioneer in Perinatal and Placental Pathology.

Kurt Benirschke, noted pathologist and animal conservationist, passed away on September 10, 2018 at the age of 94. Kurt Benirschke is a legendary figure in perinatal pathology and was likely the first pathologist to have a genuine interest in the placenta. With Shirley Driscoll, he wrote the first textbook on placental pathology-The Pathology of the Human Placenta published in 1967. Dr Benirschke combined interests in both human and animal biology-not only was he a noted pathologist and geneticist, but he had expertise in the reproduction of humans and many mammalian species. During his career, he advanced comparative pathology of placentation, and due to his work on the preservation of endangered species, he likely saved a number of species from extinction. He also became internationally known for his creation of the "frozen zoo" collecting embryos and tissues of numerous endangered species. I have been privileged to be among his many friends and colleagues who were awed by the breadth of his extensive knowledge, his humility, and his sense of humor. Benirschke's life and career, which is reviewed here, should be an inspiration to the Pediatric and Developmental Pathology readership.

The History of Pathologists' Assistants: A Tale of 2 Educational Mavericks.

CONTEXT.­: The use of medical technologists to assist with clinical pathology workload has been common since the 1930s. In stark contrast, most aspects of anatomical pathology have traditionally been considered to be medical work that must be performed by pathologists or residents. OBJECTIVE.­: To describe the history of the pathologists' assistant profession in North America. DESIGN.­: Available primary and secondary historical sources were reviewed. RESULTS.­: The concept of physician assistants, capable of performing delegated medical tasks, was created by Eugene A. Stead Jr, MD, at Duke University in 1965. When this profession began, it was quickly embraced by the American Medical Association, which took ownership related to certification and licensing of practitioners as well as external accreditation of training programs. Because of concerns about pathology manpower in the late 1960s, Thomas D. Kinney, MD, also at Duke University, developed the first training program for pathologists' assistants in 1969. Pathologists' assistants were not immediately accepted by many academic pathologists, especially related to work in the surgical pathology gross room. Organized pathology did not help the new profession develop standards, and so in 1972 pathologists' assistants created their own professional organization, the American Association of Pathologists' Assistants. Although it took several decades, the association was eventually able to forge relationships with the National Accrediting Agency for Clinical Laboratory Sciences for training program accreditation and the American Society for Clinical Pathology for board certification for practitioners. The development of the profession in Canada is also described. CONCLUSIONS.­: The pathologists' assistant profession is now well established in North America.

Pioneer in Pediatric Pathology: William A (Bill) Newton Jr (1923-).

William A (Bill) Newton Jr practiced pediatric pathology and hematology/oncology at Children's Hospital of Columbus, Ohio, for over 40 years starting in 1952. Newton was an original member of the Pediatric Pathology Club, which preceded the Society for Pediatric Pathology, and was its president from 1968 to 1969. He published important independent observations in pediatric pathology, helped establish systematic cooperative pediatric tumor pathology review by experts, became an acclaimed expert on the diagnosis of rhabdomyosarcoma, was a critical contributor to many pediatric oncology clinical trials, made important early contributions to tumor banking in pediatrics, and trained numerous pediatric pathology and pediatric oncology fellows. Finally, he concluded his career as a humanitarian, leading important volunteer work aimed at improving pediatric cancer care in China. This most interesting pediatric pathologist was simultaneously a Brigadier General in the U.S. Army. Bill Newton's life and career, which is reviewed in detail here, should be of immense interest and an inspiration to the Pediatric & Developmental Pathology readership.