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Med Hypotheses ; 63(5): 911-5, 2004.
Artículo en Inglés | MEDLINE | ID: mdl-15488668

RESUMEN

Back in the 17th century the Derbyshire village of Eyam fell victim to the Black Death, which is thought to have arrived from London in some old clothes brought by a travelling tailor. The village population was 350 at the commencement of plague, of which only 83 survived. Led by the church leaders, the village community realized that the whole surrounding region was at risk from the epidemic, and therefore decided to seal themselves off from the other surrounding villages. In the first 275 days of the outbreak, transmission was predominantly from infected fleas to susceptible humans. From then onward, mortality sharply increased, which indicates a changing in transmission pattern. We hypothesize that the confinement facilitated the spread of the infection by increasing the contact rate through direct transmission among humans. This would be more consistent with pulmonary plague, a deadlier form of the disease. In order to test the above hypothesis we designed a mathematical model for plague dynamics, incorporating both the indirect (fleas-rats-humans) and direct (human-to-human) transmissions of the infection. Our results show remarkable agreement between data and the model, lending support to our hypotheses. The Eyam plague episode is celebrated as a remarkable act of collective self-sacrifice. However, to the best of our knowledge, there were no evidence before that the confinement actually increased the burden payed by the commoners. In the light of our results, it can be said that the hypothesis that confinement facilitated the spread of the infection by increasing the contact rate through direct transmission is plausible.


Asunto(s)
Modelos Biológicos , Peste/parasitología , Peste/transmisión , Siphonaptera/patogenicidad , Aislamiento Social , Infecciones por Yersinia pseudotuberculosis/parasitología , Infecciones por Yersinia pseudotuberculosis/transmisión , Animales , Enfermedades Transmisibles/historia , Enfermedades Transmisibles/mortalidad , Enfermedades Transmisibles/parasitología , Enfermedades Transmisibles/transmisión , Simulación por Computador , Diagnóstico Diferencial , Brotes de Enfermedades/historia , Inglaterra/epidemiología , Grecia , Historia del Siglo XVIII , Historia Antigua , Humanos , Peste/mortalidad , Ratas , Infecciones por Yersinia pseudotuberculosis/mortalidad
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