RESUMEN
PURPOSE: Fuchs flecks (FFs) have been previously identified at the leading edge of pterygia and may represent collections of epithelial stem-like cells that give rise to this condition. This study aims to evaluate the clinical significance of FFs in patients with ocular surface disorders, such as pterygium and pinguecula, by in vivo confocal microscopy (IVCM). METHODS: This study is a Single-center, retrospective, observational case series of 40 eyes from 20 patients with clinical diagnoses of pinguecula or pterygium, or both. IVCM (Rostock Cornea Module; Heidelberg Engineering, Heidelberg, Germany) was performed on patients with pinguecula or pterygium, or both. The presence of FFs on the ocular surface of patients with pterygium and pinguecula was assessed by IVCM and subsequently documented. RESULTS: FFs were present in 24 of 30 eyes (80.0%) in paired macroscopically normal nasal or limbal regions, 19 of 20 (95.0%) in pinguecula, 13 of 15 (86.7%) in primary pterygia, and 7 of 7 (100%) in recurrent pterygia. CONCLUSIONS: High rates of FFs were identified at the head of pinguecula, primary pterygium, recurrent pterygium, and macroscopically normal nasal and temporal limbus. We postulate that FFs may represent precursor lesions to UV-associated ocular surface pathology. Identification of Fuchs fleck by IVCM may permit clinicians to predict the patients who may progress to develop more advanced pathology.
Asunto(s)
Conjuntiva/efectos de la radiación , Limbo de la Córnea/patología , Pinguécula/diagnóstico , Pterigion/diagnóstico , Traumatismos por Radiación/diagnóstico , Células Madre/patología , Rayos Ultravioleta/efectos adversos , Adulto , Anciano , Femenino , Humanos , Masculino , Microscopía Confocal , Persona de Mediana Edad , Pinguécula/etiología , Pterigion/etiología , Traumatismos por Radiación/etiología , Estudios RetrospectivosRESUMEN
Ophthalmoheliosis are a class of diseases in which acute or chronic exposure to UV radiation is crucial. Pathology is different, depending on the duration, wave-lenghth, size and intensity of exposure. The aim of this paper is to highlight the mechanisms by which UVR absorption occurs in the eye and patho-physiological changes with many types of pathology. There are also presented categories risk factors and preventive measures of the disease.
Asunto(s)
Oftalmopatías/etiología , Oftalmopatías/patología , Rayos Ultravioleta/efectos adversos , Catarata/etiología , Catarata/patología , Lentes de Contacto , Oftalmopatías/fisiopatología , Oftalmopatías/prevención & control , Neoplasias del Ojo/etiología , Neoplasias del Ojo/patología , Anteojos , Neoplasias de los Párpados/etiología , Neoplasias de los Párpados/patología , Humanos , Queratitis/etiología , Queratitis/patología , Degeneración Macular/etiología , Degeneración Macular/patología , Pinguécula/etiología , Pinguécula/patología , Pterigion/etiología , Pterigion/patología , Medición de Riesgo , Factores de Riesgo , Estaciones del AñoRESUMEN
CASE REPORT: We present a case report of a 28-year-old patient with a lesion that is compatible both clinically and histopathologically with conjunctival keratoacanthoma. The treatment given was complete excision and 0.04% mitomycin C eye drops in the postoperative period. The outcome was a complete clinical remission during the follow-up period (6 months). DISCUSSION: It is important to make a correct differential diagnosis between keratoacanthoma and squamous cell carcinoma, as well as carrying out close monitoring after surgery due to the possibility of relapse and conversion to squamous cell carcinoma. For this reason, we propose the use of conjunctival impression cytology as a non-invasive method for monitoring such patients.