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1.
Eur Spine J ; 33(3): 932-940, 2024 Mar.
Artículo en Inglés | MEDLINE | ID: mdl-37947889

RESUMEN

BACKGROUND: Symptoms of cauda equina syndrome (CES) secondary to degenerative lumbar spine diseases are sometimes mild and tend to be ignored by patients, resulting in delayed treatment. In addition, the long-term efficacy of surgery is unclear. OBJECTIVE: To determine the predictive factors of CES and post-operative recovery in patients with symptoms lasting > 3 months. METHODS: From January 2011 to December 2020, data of 45 patients with CES secondary to lumbar disk herniation/lumbar spinal stenosis were collected from a single center. The patients had bladder, bowel or sexual dysfunction and decreased perineal sensation that lasted for > 3 months. A 2-year post-operative follow-up was conducted to evaluate recovery outcomes, which were measured by validated self-assessment questionnaires conducted by telephone and online. RESULTS: Overall, 45 CES patients (57.8% female; mean age, 56 years) were included. The duration of pre-operative CES symptoms was 79.6 weeks (range, 13-730 weeks). The incidence of saddle anesthesia before decompression was 71.1% (n = 32), bladder dysfunction 84.4% (n = 38), bowel dysfunction 62.2% (n = 28) and sexual dysfunction 64.4% (n = 29). The overall recovery rate of CES after a 2-year follow-up was 64.4%. The rates of the residual symptoms at the last follow-up were as follows: saddle anesthesia 22.2%, bladder dysfunction 33.3%, bowel dysfunction 24.4% and sexual dysfunction 48.9%. Pre-operative saddle anesthesia, overactive bladder and sexual dysfunction were risk factors for poor prognosis after decompression. CONCLUSION: CES patients with symptoms lasting > 3 months may recover after surgery. Sexual dysfunction has a high residual rate and should not be ignored during diagnosis and treatment.


Asunto(s)
Síndrome de Cauda Equina , Cauda Equina , Desplazamiento del Disco Intervertebral , Polirradiculopatía , Humanos , Femenino , Persona de Mediana Edad , Masculino , Síndrome de Cauda Equina/cirugía , Síndrome de Cauda Equina/etiología , Autoevaluación (Psicología) , Estudios Retrospectivos , Desplazamiento del Disco Intervertebral/cirugía , Descompresión/efectos adversos , Polirradiculopatía/etiología , Polirradiculopatía/cirugía
2.
Artículo en Inglés | MEDLINE | ID: mdl-37967093

RESUMEN

This case offers a safe and effective method for treating lumbopelvic dissociation in a pediatric patient with cauda equina syndrome using a triangular osteosynthesis construct. After a high-speed accident, an 11-year-old girl was admitted to the hospital with bowel and bladder incontinence and bilateral lower extremity weakness. The orthopaedic trauma and spine teams elected for surgical treatment with a triangular osteosynthesis construct, a procedure usually reserved for adults. The surgery was uncomplicated, and the patient experienced complete resolution of her preoperative symptoms. She is doing well over 1-year postoperatively, with full neurologic recovery, maintained reduction, bony healing, and subsequent implant removal. To our knowledge, this is the youngest reported case of lumbopelvic dissociation treated in this manner and represents a viable treatment option.


Asunto(s)
Síndrome de Cauda Equina , Polirradiculopatía , Humanos , Adulto , Femenino , Niño , Síndrome de Cauda Equina/cirugía , Síndrome de Cauda Equina/complicaciones , Polirradiculopatía/etiología , Polirradiculopatía/cirugía , Polirradiculopatía/diagnóstico , Descompresión Quirúrgica/efectos adversos , Descompresión Quirúrgica/métodos , Columna Vertebral/cirugía , Fijación Interna de Fracturas/efectos adversos
3.
JBJS Case Connect ; 12(2)2022 04 01.
Artículo en Inglés | MEDLINE | ID: mdl-36099503

RESUMEN

CASE: "Baastrup's disease" is a relatively common anatomical condition, controversially recognized as a possible cause of back pain but frequently missed by clinicians of different specialties. We present a rare case of Baastrup's disease causing compression to the cauda equina nerves due to the formation of a large pseudotumoral epidural mass. The patient underwent a successful surgical decompression with remarkable improvement in her neurological presentation. The histopathological findings consisted of increased collagen deposition and chondroid metaplasia. CONCLUSION: Clinicians should be aware of possible cauda equina syndrome in rare cases of Baastrup's disease due to pseudotumoral mass compression in the lumbar spine.


Asunto(s)
Síndrome de Cauda Equina , Cauda Equina , Polirradiculopatía , Cauda Equina/diagnóstico por imagen , Cauda Equina/patología , Cauda Equina/cirugía , Síndrome de Cauda Equina/etiología , Síndrome de Cauda Equina/cirugía , Descompresión Quirúrgica/efectos adversos , Femenino , Humanos , Vértebras Lumbares/cirugía , Polirradiculopatía/etiología , Polirradiculopatía/patología , Polirradiculopatía/cirugía
4.
Orthop Clin North Am ; 53(2): 247-254, 2022 Apr.
Artículo en Inglés | MEDLINE | ID: mdl-35365269

RESUMEN

Cauda equina syndrome (CES) involves compression of some or all of the lumbar and sacral peripheral nerve roots. However, there is a lack of consensus in the literature regarding the exact diagnosis criteria in this patient population. Much of the pathophysiology has been studied regarding the onset of this condition; however, the long-term effects are not able to be accurately predicted at this time. Recent literature has associated timing to surgical decompression, severity of symptoms at time of onset, and involvement of bladder dysfunction as prognostic indicators of CES.


Asunto(s)
Síndrome de Cauda Equina , Cauda Equina , Polirradiculopatía , Cauda Equina/cirugía , Síndrome de Cauda Equina/diagnóstico , Síndrome de Cauda Equina/etiología , Síndrome de Cauda Equina/cirugía , Descompresión Quirúrgica , Humanos , Polirradiculopatía/diagnóstico , Polirradiculopatía/etiología , Polirradiculopatía/cirugía , Pronóstico
5.
BMC Neurol ; 22(1): 90, 2022 Mar 14.
Artículo en Inglés | MEDLINE | ID: mdl-35287603

RESUMEN

BACKGROUND: The long-term use of an oral corticosteroid suppresses immunity. Here, we describe a case involving a patient with weakness in the bilateral lower extremities due to cytomegalovirus (CMV) lumbosacral polyradiculitis. CASE PRESENTATION: A 64-year-old man visited a university hospital for symmetric motor weakness in both lower extremities (Medical Research Council grade: 2). Symptoms started 1 month before and gradually aggravated. The patient had been taking oral prednisolone for 10 years in order to control pain in multiple joints due to seronegative rheumatoid arthritis. He also had neuropathic pain on the entire right lower extremity and voiding difficulty. Gadolinium-enhanced magnetic resonance imaging revealed enhancement along the entire lumbosacral nerve roots. In the cerebrospinal fluid analysis (CSF), elevated white blood cell (WBC) count (19 cells/µL) and protein level (142.5 mg/dL) were observed. CMV detection by polymerase chain reaction (PCR) was positive. We diagnosed the patient as having lumbosacral polyradiculitis due to CMV. Ganciclovir (250 mg twice daily) was administered intravenously. Two months after initiating Ganciclovir, in the CSF analysis, CM detection by PCR was negative, and no WBC was found. CONCLUSION: We reported a patient who had symmetric motor weakness in the bilateral lower extremities induced by CMV lumbosacral polyradiculitis. Its occurrence seems to be related to immunosuppresion due to the long-term use of an oral corticosteroid. When a patient who is taking an oral corticosteroid shows motor weakness in the bilateral lower extremities, CMV lumbosacral polyradiculitis is one of the possible disorders to be differentiated.


Asunto(s)
Infecciones por Citomegalovirus , Polirradiculopatía , Corticoesteroides , Citomegalovirus , Infecciones por Citomegalovirus/complicaciones , Infecciones por Citomegalovirus/tratamiento farmacológico , Ganciclovir , Humanos , Masculino , Persona de Mediana Edad , Polirradiculopatía/diagnóstico , Polirradiculopatía/etiología
6.
Eur Spine J ; 31(2): 353-363, 2022 02.
Artículo en Inglés | MEDLINE | ID: mdl-34581849

RESUMEN

PURPOSE: This study aimed to investigate the long-term clinical outcomes after surgical decompression in cauda equina syndrome (CES) and see if any preoperative patient-related factors contributed to this outcome. METHODS: A systematic literature search was conducted in the electronic databases of PubMed, Embase, Scopus, and Ovid. Data regarding outcome parameters from eligible studies were extracted. Meta-analysis was performed using a random-effect model. RESULTS: A total of 852 patients (492 males and 360 females), with a mean age of 44.6 ± 5.5 years from 22 studies diagnosed with cauda equina syndrome and undergoing surgical decompression, were included in the meta-analysis; however, not all studies reported every outcome. The mean follow-up period was 39.2 months, with a minimum follow-up of 12 months in all included studies. Meta-analysis showed that on long-term follow-up, 43.3% [29.1, 57.5] (n=708) of patients had persistent bladder dysfunction. Persistent bowel dysfunction was observed in 31.1% [14.7, 47.6] (n=439) cases, sensory deficit in 53.3% [37.1, 69.6] (n=519), motor weakness in 38.4% [22.4, 54.4] (n=490), and sexual dysfunction in 40.1% [28.0, 52.1] (n=411). Decompression within 48 hours of the onset of symptoms was associated with a favourable outcome in terms of bladder function with 24.6% [1.6, 50.9] (n=75) patients having persistent dysfunction, whereas 50.3% [10.3, 90.4] (n=185) of patients in studies with a mean time to decompression after 48 hours had persistent bladder dysfunction. Other factors such as speed of onset and sex of the patients were not found to significantly impact long-term bladder outcomes. CONCLUSION: The long-term outcomes of CES after decompression are enumerated. Decompression within 48 hours of the onset of symptoms appears to result in fewer patients with persistent bladder dysfunction. However, a randomized controlled trial is required to conclusively determine whether early decompression leads to better outcomes.


Asunto(s)
Síndrome de Cauda Equina , Cauda Equina , Desplazamiento del Disco Intervertebral , Polirradiculopatía , Disfunciones Sexuales Fisiológicas , Adulto , Cauda Equina/cirugía , Síndrome de Cauda Equina/etiología , Síndrome de Cauda Equina/cirugía , Descompresión Quirúrgica/efectos adversos , Femenino , Humanos , Desplazamiento del Disco Intervertebral/complicaciones , Desplazamiento del Disco Intervertebral/cirugía , Vértebras Lumbares/cirugía , Masculino , Persona de Mediana Edad , Polirradiculopatía/etiología , Polirradiculopatía/cirugía , Disfunciones Sexuales Fisiológicas/etiología , Vejiga Urinaria
7.
Spine (Phila Pa 1976) ; 47(2): 105-113, 2022 Jan 15.
Artículo en Inglés | MEDLINE | ID: mdl-34265807

RESUMEN

STUDY DESIGN: A prospective patient's database operated on a cauda equina syndrome (CES). OBJECTIVE: The aim of our study was to identify prognosis factors for favorable functional recovery after CES. SUMMARY OF BACKGROUND DATA: CES is a neurologic impairment of variable symptoms associating urinary, bowel, and sexual dysfunctions with or without motor or sensitive deficits caused by nerve root compression of the cauda equina. The definition of CES remains debated, as well as the prognosis factors for favorable functional recovery and the benefit of early surgery. METHODS: One hundred forty patients were included between January 2010 and 2019. Univariate and multivariate cox proportional hazard regression models were conducted. RESULTS: The patients were young with a median age of 46.8 years (range 18-86 yrs). At presentation, 60% were affected by a motor deficit, 42.8% a sensitive deficit, 70% urinary dysfunctions, and 44% bowel dysfunctions. The mean follow-up was 15.5 months. Bilateral motor deficit (P = 0.017) and an initial deficit severity of 0 to 2 (P = 0.001) represented prognosis factors of poor motor recovery. Initial anal incontinence (P = 0.007) was associated with poor bowel recovery. Only 32.8% of the patients went back to work. Initial motor deficit (P = 0.015), motor sequelae (P = 0.001), sphincter dysfunctions sequelae (P = 0.02), and long LOS (P = 0.02) were poor return-to-work prognosis factors. Time to surgery within an early timing < 24 or 48 hours or later did not represent a prognosis factor of recovery in CES. Incomplete versus complete CES did not show better recovery. CONCLUSION: CES remains a profound disabling syndrome with poor functional prognosis: in the long run, few patients go back to work. The main prognosis factors established in our series regarded the initial severity of deficits whether motor or sphincteral. Early or later surgical cauda equina decompression did not show to represent a prognosis factor for functional recovery.Level of Evidence: 4.


Asunto(s)
Síndrome de Cauda Equina , Cauda Equina , Polirradiculopatía , Adolescente , Adulto , Anciano , Anciano de 80 o más Años , Cauda Equina/cirugía , Síndrome de Cauda Equina/cirugía , Descompresión Quirúrgica , Humanos , Persona de Mediana Edad , Polirradiculopatía/diagnóstico , Polirradiculopatía/etiología , Polirradiculopatía/cirugía , Pronóstico , Estudios Prospectivos , Estudios Retrospectivos , Adulto Joven
8.
World Neurosurg ; 159: e208-e220, 2022 Mar.
Artículo en Inglés | MEDLINE | ID: mdl-34915208

RESUMEN

BACKGROUND: Cauda equina syndrome (CES) can have devastating neurological sequelae if surgical treatment is delayed. However, out-of-hours surgery (weekdays from 6:00 pm to 8:00 am and all weekend operations) can potentially result in higher rates of intraoperative complications, resulting in worse outcomes. In the present study, we have described our outcomes for patients with CES during an 8-year period (December 2011 to October 2019) with the aim of assessing the risk of out-of-hours surgery. METHODS: We performed a retrospective analysis of inpatient events and outcomes at 6 months of follow-up. Patient demographics, symptoms, and management data were extracted, and a risk factor analysis was performed using logistic regression. The outcome measures were the incidence of complications and symptom changes at follow-up. Symptom outcome changes between 2 time points were analyzed using repeated measures. RESULTS: A total of 278 patients were included in the present study. Surgery out-of-hours (P = 0.018) and prolonged operations (P = 0.018) were significant risk factors for intraoperative complications. Improved outcomes at 6 months of follow-up were found for lower back pain, sciatica, altered saddle sensation, and urinary sphincter disturbance, with no significant changes for the remaining symptoms. Out-of-hours surgeries did not significantly affect individual symptom outcomes. CONCLUSIONS: Our analysis has suggested that emergency decompressive surgery for patients with CES does not result in worsening of outcomes with out-of-hours surgery compared with in-hours. However, our findings also showed that no clear benefit exists to expediting surgery for those with severe presentations. Thus, decompressive surgery should be undertaken at the earliest possible time to safely do so.


Asunto(s)
Atención Posterior , Síndrome de Cauda Equina , Cauda Equina , Polirradiculopatía , Cauda Equina/cirugía , Síndrome de Cauda Equina/etiología , Descompresión Quirúrgica/efectos adversos , Humanos , Complicaciones Intraoperatorias/etiología , Polirradiculopatía/etiología , Estudios Retrospectivos , Reino Unido/epidemiología
9.
J Med Case Rep ; 15(1): 455, 2021 Sep 14.
Artículo en Inglés | MEDLINE | ID: mdl-34517890

RESUMEN

BACKGROUND: Cauda equina syndrome is a rare clinical condition that requires prompt diagnosis and timely surgical decompression with postoperative rehabilitation to prevent devastating complications. CASE PRESENTATION: A 55-year-old Sinhalese woman presented with a vulval abscess, with a history of involuntary leakage of urine for the last 7 years. Her sexual activity has been compromised due to coital incontinence, and she had also been treated for recurrent urinary tract infections during the last 7 years. On examination, a distended bladder was found. Neurological examination revealed a saddle sensory loss of S2-S4 dermatomes. There was no sensory loss over the lower limbs. Bladder sensation was absent, but there was some degree of anal sphincter tone. Motor functions and reflexes were normal in the limbs. Magnetic resonance imaging revealed L5-S1 spondylolisthesis. Ultrasound imaging confirmed the finding of a distended bladder, in addition to bilateral hydroureters with hydronephrosis. An incision and drainage with concomitant intravenous antibiotics were started for the vulval abscess. An indwelling catheter was placed to decompress the bladder and to reduce vulval excoriations due to urine. Bilateral ureteric stenting was performed later for persistent hydronephrosis and hydroureter despite an empty bladder. CONCLUSION: This is a tragic case that illustrates the devastating long-term sequelae that ensues if cauda equina syndrome is left undiagnosed. It reiterates the importance of prompt referral and surgical decompression.


Asunto(s)
Cauda Equina , Polirradiculopatía , Absceso/diagnóstico por imagen , Absceso/cirugía , Descompresión Quirúrgica , Femenino , Humanos , Imagen por Resonancia Magnética , Persona de Mediana Edad , Polirradiculopatía/diagnóstico por imagen , Polirradiculopatía/etiología , Polirradiculopatía/cirugía
10.
Spine J ; 21(5): 803-809, 2021 05.
Artículo en Inglés | MEDLINE | ID: mdl-33434651

RESUMEN

BACKGROUND CONTEXT: Cauda equina syndrome (CES) occurs due to compression of the lumbar and sacral nerve roots and is considered a surgical emergency. Although the condition is relatively rare, the associated morbidity can be devastating to patients. While substantial research has been conducted on the timing of treatment, the literature regarding long-term rates of bladder dysfunction in CES patients is scarce. PURPOSE: The aim of this study was to identify long-term rates of bladder dysfunction in CES patients and to compare those rates to non-CES patients who underwent similar spinal decompression. STUDY DESIGN/SETTING: Retrospective database study. PATIENT SAMPLE: The CES cohort was comprised of 2,362 patients who underwent decompression surgery following CES diagnosis with a 5-year follow-up. These patients were matched to 9,448 non-CES control patients who underwent spinal decompression without a diagnosis of CES. OUTCOME MEASURES: Diagnosis of bladder dysfunction, surgical procedure to address bladder dysfunction METHODS: Using the national insurance claims database, PearlDiver, CES patients who underwent decompression surgery were identified and 1:4 matched to non-CES patients who underwent similar spinal decompression surgery. The 1-year, 3-year, and 5-year rates of progression to a bladder dysfunction diagnosis and surgical intervention to manage bladder dysfunction were recorded. The CES and non-CES groups were compared with univariate testing, and an analysis of risk factors for bladder dysfunction was performed with multivariate logistic regression analysis. RESULTS: A total of 2,362 CES patients who underwent decompression surgery were identified and matched to 9,448 non-CES control patients. After 5 years, CES patients had a 10%-12% increased absolute risk of continued bladder dysfunction and a 0.7%-0.9% increased absolute risk of undergoing a surgical procedure for bladder dysfunction, as compared to matched non-CES patients. Multivariate analysis controlling for age, sex, obesity, tobacco use, and diabetes, identified CES as independently associated with increased 5-year risk for bladder dysfunction diagnosis (odds ratio [OR]: 1.72; 95% confidence interaval [CI] 1.56-1.89; p<.001) and procedure (OR: 1.40; 95% CI 1.07-1.81; p=.012). CONCLUSIONS: Understanding the long-term risk for bladder dysfunction in CES patients is important for the future care and counseling of patients. Compared to non-CES patients who underwent similar spinal decompression, CES patients were observed to have a significantly higher long-term likelihood for both bladder dysfunction diagnosis and urologic surgical procedure.


Asunto(s)
Síndrome de Cauda Equina , Cauda Equina , Polirradiculopatía , Síndrome de Cauda Equina/epidemiología , Síndrome de Cauda Equina/etiología , Descompresión Quirúrgica/efectos adversos , Humanos , Polirradiculopatía/epidemiología , Polirradiculopatía/etiología , Polirradiculopatía/cirugía , Estudios Retrospectivos , Vejiga Urinaria/cirugía
11.
Am J Trop Med Hyg ; 104(1): 298-302, 2021 01.
Artículo en Inglés | MEDLINE | ID: mdl-33124542

RESUMEN

Spinal sparganosis of the cauda equina has been rarely reported. A 54-year-old man presented at the hospital after having experienced lower back pain for 10 months, progressive weakness and numbness of the left leg for 4 months, and urinary incontinence for 3 weeks. Magnetic resonance imaging of the lumbosacral spine revealed a heterogeneous enhancing mass at the T12-S1 level. Spinal sparganosis was diagnosed by histological examination and molecular identification of the parasite in the tissue section. The patient was treated with a high dose of praziquantel because the parasitic mass was only partially removed and symptoms worsened following surgery.


Asunto(s)
Cauda Equina/parasitología , Esparganosis/diagnóstico , Antihelmínticos/administración & dosificación , Antihelmínticos/uso terapéutico , Antiulcerosos/administración & dosificación , Antiulcerosos/uso terapéutico , Cauda Equina/diagnóstico por imagen , Cauda Equina/patología , Cimetidina/administración & dosificación , Cimetidina/uso terapéutico , Humanos , Masculino , Persona de Mediana Edad , Polirradiculopatía/etiología , Praziquantel/administración & dosificación , Praziquantel/uso terapéutico , Esparganosis/patología , Esparganosis/cirugía
12.
J Emerg Med ; 58(5): 802-806, 2020 May.
Artículo en Inglés | MEDLINE | ID: mdl-32284228

RESUMEN

BACKGROUND: Occlusive abdominal aortic thrombus is a rare but critical clinical emergency with life-threatening consequences. Clinical presentation may mimic other diagnoses, resulting in a delay in the appropriate investigations for this condition. Spinal arterial involvement is a recognized complication of aortic thrombus and can result in pain, lower limb weakness, and loss of continence. These symptoms are usually associated with local spinal compression or stenosis manifesting as cauda equina syndrome (CES): a clinical finding of disrupted motor and sensory function to the lower extremities and bladder. CASE REPORT: We present a case of a 60-year-old female patient presenting with back pain, leg weakness, paresthesia, and urinary incontinence. She was urgently investigated for cauda equina syndrome via a magnetic resonance imaging scan of the spine, which subsequently demonstrated a large occlusive abdominal aortic thrombus. WHY SHOULD AN EMERGENCY PHYSICIAN BE AWARE OF THIS?: Nontraumatic acute thrombosis of the aorta is a life-threatening condition that may present with apparent neurological symptoms. In this patient there was both a relevant history and evolving clinical signs pointing toward a vascular etiology; however, the clinical findings were confusing and CES evaluation was prioritized. CES remains a medical emergency requiring urgent investigation and management. However, knowledge of spinal anatomy including vascular supply may help widen the differential. Physicians and associate specialists should consider this at clinical assessment and also when interpreting imaging of the spine. Any delay in diagnosing an aortic thrombosis has the potential for catastrophic clinical consequences.


Asunto(s)
Síndrome de Cauda Equina , Polirradiculopatía , Trombosis , Aorta/diagnóstico por imagen , Aorta/patología , Dolor de Espalda , Femenino , Humanos , Imagen por Resonancia Magnética , Persona de Mediana Edad , Polirradiculopatía/diagnóstico , Polirradiculopatía/etiología , Trombosis/complicaciones , Trombosis/diagnóstico
13.
J Clin Neurosci ; 74: 240-241, 2020 Apr.
Artículo en Inglés | MEDLINE | ID: mdl-31983645

RESUMEN

Immune checkpoint inhibitors, also known as immunotherapy, have revolutionised the treatment of metastatic melanoma, but are frequently associated with immune-related adverse events (irAEs) affecting a variety of organ systems. Here, we present a case of a patient with metastatic melanoma, being treated with combination ipilimumab-nivolumab, who developed a foot drop. MRI demonstrated enhancement of the nerve roots of the cauda equina. The patient had other irAEs, which warranted cessation of immunotherapy and the introduction of corticosteroids, and this also resulted in improvement in the patient's lower limb symptoms and MRI appearances. This confirmed an autoimmune polyradiculitis - a rare irAE.


Asunto(s)
Antineoplásicos Inmunológicos/efectos adversos , Factores Inmunológicos/uso terapéutico , Ipilimumab/efectos adversos , Melanoma/tratamiento farmacológico , Nivolumab/efectos adversos , Polirradiculopatía/etiología , Protocolos de Quimioterapia Combinada Antineoplásica/efectos adversos , Humanos , Inmunoterapia , Imagen por Resonancia Magnética , Masculino , Persona de Mediana Edad , Neoplasias Primarias Secundarias , Nervios Espinales/patología
15.
Neurocirugía (Soc. Luso-Esp. Neurocir.) ; 30(6): 278-287, nov.-dic. 2019. ilus, tab
Artículo en Inglés | IBECS | ID: ibc-186957

RESUMEN

Objective: Cauda equina syndrome (CES) caused by lumbar disk extrusion is classically considered an indication of urgent surgery. CES can be subdivided into CESI (incomplete CES) and CESR (complete CES with urinary retention and incontinence). This paper evaluates the long-term functional outcome of a CES cohort operated on due to disk herniation. Methods: Single-center retrospective observational study. CES patients due to disk herniation that underwent surgery between 2000 and 2016 were included in the study. Demographic data, time intervals to diagnosis and surgery, preoperative neurologic status and outcome at the end of follow up were recorded. Results: Twenty-two patients were included (median age 44 years). Eight patients were CESR and 14 CESI. Median time from symptom onset to diagnosis was 78h (range, 12-720h), and from diagnosis to surgery 24h (range, 5-120h). Median follow up was 75 months (range, 20-195 months). At the end of follow up, in the CESR group (median time from diagnosis to surgery, 23h) only pain significantly improved after surgery (p=0.007). In the CESI group (median time from diagnosis to surgery 23h) low back pain, sciatica and urinary sphincter function significantly improved (p<0.001). There were no significant differences between early (<48h) operation (n=4) and late (n=18) in terms of sphincter recovery (Fisher's Exact Test, p=0.076). Conclusion: Pain associated to CES improved both in the CESI and CESR groups. However, urinary sphincter impairment significantly improved only in the CESI group. No significant differences were found regarding long-term functional outcome between early and late surgery


Objetivo: El síndrome de cola de caballo (SCC) producido por extrusión discal se ha considerado clásicamente una urgencia neuroquirúrgica. El SCC puede dividirse en SCC-I (incompleto) y en SCC-C (completo, con retención urinaria e incontinencia). Este trabajo evalúa el pronóstico funcional a largo plazo de una cohorte de pacientes con SCC por hernia discal intervenidos. Material y métodos: Estudio observacional retrospectivo unicéntrico. Se incluyeron todos los pacientes diagnosticados de SCC por hernia discal e intervenidos en el período 2000-2016. Se recogieron datos demográficos, intervalos de tiempo entre el inicio de síntomas, el diagnóstico y la cirugía, y estado neurológico preoperatorio y al final del seguimiento. Resultados: Se incluyeron un total de 22 pacientes (edad mediana de 44 años). Ocho casos fueron SCC-C y 14 SCC-I. El tiempo medio desde el inicio de los síntomas hasta el diagnóstico fue de 78h (rango, 12-720h), y desde el diagnóstico hasta la cirugía de 24h (rango, 5-120h). El seguimiento mediano fue de 75 meses (rango, 20-195). Al final del seguimiento, en el grupo SCC-C (tiempo medio desde diagnóstico hasta la cirugía, 23h) sólo el dolor mejoró de forma significativa tras la cirugía (p = 0,007). En el grupo SCC-I (tiempo medio desde diagnóstico hasta la cirugía, 23h) mejoraron significativamente el dolor lumbar, la ciática y el control del esfínter urinario (p < 0.01). No se constataron diferencias significativas entre los operados precozmente (antes de 48h, n = 4) y tardíamente (n = 18) en relación a la recuperación esfinteriana (Test exacto de Fisher, p = 0,076). Conclusión: El dolor asociado al SCC mejoró tanto en los casos completos como incompletos. Sin embargo, el control del esfínter urinario sólo mejoró significativamente en los pacientes con síndromes incompletos. No se encontraron diferencias significativas en cuanto al resultado funcional a largo plazo entre intervenidos precoz y tardíamente


Asunto(s)
Humanos , Masculino , Femenino , Adulto , Persona de Mediana Edad , Desplazamiento del Disco Intervertebral/complicaciones , Desplazamiento del Disco Intervertebral/cirugía , Polirradiculopatía/cirugía , Pronóstico , Polirradiculopatía/etiología , Estudios Retrospectivos , Laminectomía/métodos
18.
Dtsch Arztebl Int ; 115(45): 751-756, 2018 Nov 09.
Artículo en Inglés | MEDLINE | ID: mdl-30573008

RESUMEN

BACKGROUND: The new German S3 guideline on Lyme neuroborreliosis is intended to provide physicians with scientifically based information and recommendations on the diagnosis and treatment of this disease. METHODS: The scientific literature was systematically searched and the retrieved publications were assessed at the German Cochrane Center (Deutsches Cochrane Zentrum) in Freiburg in the 12 months beginning in March 2014. In addition to the main search terms "Lyme disease," "neuroborreliosis," "Borrelia," and "Bannwarth," 28 further terms relating to neurological manifestations of the disease were used for the search in the Medline and Embase databases and in the Cochrane Central Register of Controlled Trials. RESULTS: In the treatment of early Lyme neuroborreliosis, orally administered doxycycline is well tolerated, and its efficacy is equivalent to that of intravenously administered beta-lactam antibiotics (penicillin G, ceftriaxone, and cefotaxime) (relative risk [RR]: 0.98, 95% confidence interval [CI]: [0.68; 1.42], P = 0.93). 14 days of treatment suffice for early Lyme neuroborreliosis, and 14-21 days of treatment usually suffice for late (chronic) Lyme neuroborreliosis. CONCLUSION: Lyme neuroborreliosis has a favorable prognosis if treated early. The long-term administration of antibiotics over many weeks or even months for putative chronic Lyme neuroborreliosis with nonspecific symptoms yields no additional benefit and carries the risk of serious adverse effects.


Asunto(s)
Neuroborreliosis de Lyme/diagnóstico , Neuroborreliosis de Lyme/tratamiento farmacológico , Antibacterianos/uso terapéutico , Borrelia/efectos de los fármacos , Borrelia/patogenicidad , Doxiciclina/uso terapéutico , Humanos , Polirradiculopatía/etiología , Pronóstico , Resultado del Tratamiento
19.
Am J Case Rep ; 19: 694-698, 2018 Jun 15.
Artículo en Inglés | MEDLINE | ID: mdl-29904039

RESUMEN

BACKGROUND Epidural venous plexus (EVP) engorgement occurs due to many conditions, so it can be easily misdiagnosed. This becomes problematic when the diagnosis requires prompt treatment for a good outcome, especially when it results in cauda equina syndrome (CES). We report a case of extensive iliocaval thrombosis leading to epidural venous plexus and ascending lumbar vein engorgement as an outcome of deep venous thrombosis (DVT) due to probable adverse effects of oral combined contraceptive pills (OCCP). CASE REPORT A 42-year-old woman presented to a rural medical facility with bilateral lower-limb swelling and skin darkening for 2 days. She was transferred to a tertiary medical facility where her condition deteriorated to severe CES. A lower-limbs ultrasonography confirmed the presence of extensive DVT extending to the lower segment of the inferior vena cava. Spine magnetic resonance imaging showed abnormal enhancement of the conus medullaris with thick enhanced cauda equina nerve roots, consistent with a possible case of Guillain-Barré syndrome. However, there was engorgement of the EVP extending to the ascending lumbar, azygos, and hemiazygos veins, which was misdiagnosed. The patient was managed immediately with low-molecular-weight heparin and steroids. She died 4 weeks after admission due to hospital-acquired pneumonia and acute respiratory distress syndrome, probably due to the high dose of steroids. CONCLUSIONS Acute CES has a wide differential diagnosis. This report describes an unusual cause of CES and emphasizes the importance of early recognition to avoid misdiagnosis and management delay. Early identification of this clinical entity markedly decreases morbidity and mortality and thus improves the prognosis. Likewise, underlying causing factors such as venous congestion due to OCCP-related DVT should be considered in the diagnosis.


Asunto(s)
Anticonceptivos Orales Combinados/efectos adversos , Polirradiculopatía/etiología , Trombosis de la Vena/inducido químicamente , Trombosis de la Vena/diagnóstico por imagen , Adulto , Anticoagulantes/uso terapéutico , Espacio Epidural/irrigación sanguínea , Resultado Fatal , Femenino , Heparina de Bajo-Peso-Molecular/uso terapéutico , Humanos , Vena Ilíaca , Región Lumbosacra , Vena Cava Inferior , Trombosis de la Vena/tratamiento farmacológico
20.
Medicine (Baltimore) ; 97(19): e0693, 2018 May.
Artículo en Inglés | MEDLINE | ID: mdl-29742719

RESUMEN

RATIONALE: Neuraxial anesthesia is a commonly used type of regional anesthesia. Cauda equina syndrome is an unusual and severe complication of neuraxial anesthesia, and is caused by damage to the sacral roots of the neural canal. We present a case of cauda equina syndrome following spinal anesthesia in a patient who underwent Bartholin abscess drainage. PATIENT CONCERNS: A 23-year old female scheduled to undergo surgical drainage of Bartholin abscess. Spinal anesthesia was performed with bupivacaine and fentanyl. There were no perioperative adverse events reported. On postoperative day 1, the patient went to the emergency department describing bilateral weakness and pain of the lower extremities (LE). DIAGNOSES: Lumbar magnetic resonance imaging showed increased gadolinium accumulation in the neural sheath at the level of the cauda equina tracts, consistent with the diagnosis of arachnoiditis and the diagnosis of cauda equina was established. INTERVENTIONS: The patient received the following emergent treatment: 75 mg pregabalin (oral) every 12 hours, 20 mg (8 drops) tramadol (oral) every 8 hours, and 4 mg dexamethasone (intravenous) every 6 hours. On postoperative day 4, the patient still experienced bilateral flaccid paraparesis (accentuated in the left side), neuropathic pain in low extremities, and left brachial monoparesis. Hence, dexamethasone was instantly replaced with 1 g methylprednisolone (intravenous) for 5 days. OUTCOMES: After completing 5 days of methylprednisolone, on postoperative day 9, the patient experienced less pain in left extremities, osteotendinous reflexes were slightly diminished, and she was able to walk with difficulty for 3 to 5 minutes. Greater mobility was evidenced, with right proximal and distal low extremities Medical Research Council Scale grades of 2 and 3 and left proximal and distal low extremities Medical Research Council Scale grades 1 and 2, respectively. Oral prednisone was restarted. Consequently, she was discharged home in stable conditions on postoperative day 25 with a prescription for sertraline, clonazepam, pregabalin, paracetamol, and prednisone. LESSON: The early detection and treatment of complications after neuraxial anesthesia is essential to minimize the risk of permanent damage.


Asunto(s)
Absceso/cirugía , Anestesia Raquidea/efectos adversos , Anestésicos Locales/efectos adversos , Glándulas Vestibulares Mayores/cirugía , Bupivacaína/efectos adversos , Drenaje , Polirradiculopatía/etiología , Analgésicos/uso terapéutico , Antiinflamatorios/uso terapéutico , Dexametasona/uso terapéutico , Quimioterapia Combinada , Femenino , Humanos , Metilprednisolona/uso terapéutico , Polirradiculopatía/tratamiento farmacológico , Pregabalina/uso terapéutico , Tramadol/uso terapéutico , Adulto Joven
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