Calcinosis cutis with large extension and uncommon location in a dog

Background: Calcinosis cutis is an uncommon dermatopathy characterized by the deposition of minerals in the skin,usually involving collagen and elastic fibers in the dermis. Usually, it results from dystrophic calcification and can begeneralized or focal. The dermatopathy may be primary or secondary to certain disorders, especially chronic proliferativeotitis, foreign body reactions, hyperadrenocorticism (HAC) and less frequently percutaneous penetration of calcium-richproducts. The aim of this report is to describe a presentation of calcinosis cutis affecting the skin of the back, internal faceof hind limbs and anal region of a 9-years-old bitch.Case: A 9-year-old, non-defined breed, bitch, ovariohysterectomized, weighing 9.45 kg, was attended at the DermatologicalService of companion animals at the Veterinary Hospital of the Federal University of Jataí (UFJ). The animal came in withthe complaint of extensive dorsal alopecia, covered by firm lesions, with a 3-month evolution, additionally to polyuria andpolydipsia. After physical examination, alopecic areas of great extension were confirmed on the dorsum, on the internalsurface of the hind limbs and in the anal region. Also, an exudative and painful lesion located on the back was detected,plus loss of elasticity of the ventral abdomen skin and visible abdominal vessels. The screening tests showed a markedincrease in the alanine aminotransferase enzyme (ALT), alkaline phosphatase (ALP) and total cholesterol. The specificurinary density was decreased. On the ultrasound examination, hepatomegaly and an increase in the caudal pole of the leftadrenal were detected. Based on these findings, calcinosis cutis secondary to spontaneous hyperadrenocorticism (HAC)was suspected. For confirmation, skin biopsy and low dose dexamethasone suppression test (LDDS) were performed.LDDS test showed no reduction of serum cortisol after 8 h of dexamethasone dose administration and histopathological...(AU)

Calcinosis cutis with large extension and uncommon location in a dog

Background: Calcinosis cutis is an uncommon dermatopathy characterized by the deposition of minerals in the skin,usually involving collagen and elastic fibers in the dermis. Usually, it results from dystrophic calcification and can begeneralized or focal. The dermatopathy may be primary or secondary to certain disorders, especially chronic proliferativeotitis, foreign body reactions, hyperadrenocorticism (HAC) and less frequently percutaneous penetration of calcium-richproducts. The aim of this report is to describe a presentation of calcinosis cutis affecting the skin of the back, internal faceof hind limbs and anal region of a 9-years-old bitch.Case: A 9-year-old, non-defined breed, bitch, ovariohysterectomized, weighing 9.45 kg, was attended at the DermatologicalService of companion animals at the Veterinary Hospital of the Federal University of Jataí (UFJ). The animal came in withthe complaint of extensive dorsal alopecia, covered by firm lesions, with a 3-month evolution, additionally to polyuria andpolydipsia. After physical examination, alopecic areas of great extension were confirmed on the dorsum, on the internalsurface of the hind limbs and in the anal region. Also, an exudative and painful lesion located on the back was detected,plus loss of elasticity of the ventral abdomen skin and visible abdominal vessels. The screening tests showed a markedincrease in the alanine aminotransferase enzyme (ALT), alkaline phosphatase (ALP) and total cholesterol. The specificurinary density was decreased. On the ultrasound examination, hepatomegaly and an increase in the caudal pole of the leftadrenal were detected. Based on these findings, calcinosis cutis secondary to spontaneous hyperadrenocorticism (HAC)was suspected. For confirmation, skin biopsy and low dose dexamethasone suppression test (LDDS) were performed.LDDS test showed no reduction of serum cortisol after 8 h of dexamethasone dose administration and histopathological...

Evidence of pituitary hypoplasia associated with partial central diabetes insipidus in a young Persian cat

Background: Congenital anomalies are an uncommon pituitary hypofunction cause associated to multiple hormone deficiencies. Congenital hyposomatotropism is often related to an inherited anomaly, characterized mainly by delayed growth. It is not uncommon to find associated thyroid-stimulating hormone and gonadotropin deficiencies. Pituitary malformation may be associated to progressive cystic lesion expansion. Central diabetes insipidus (CDI) is another rare disease associated to polyuria (PU) and polydipsia (PD) secondary to antidiuretic hormone (ADH) deficient secretion. The aim of this report is to describe a likely case of pituitary hypoplasia, associated with partial CDI in a cat. Case: A 9-month-old unneutered male Persian cat weighing 2 kg was presented due to severe polyuria and polydipsia associated with growth deficit when compared with its sibling. After clinical and laboratory evaluations during the months in which the patient was monitored, reduced serum concentration of insulin-like growth factor-1 (IGF-1), thyroid-stimulating hormone (TSH), thyroid hormones, and testosterone were documented, confirming the diagnosis of hyposomatotropism, hypogonadism, and secondary hypothyroidism. Furthermore, therapeutic diagnosis with desmopressin revealed partial central diabetes insipidus (CDI). As the sibling showed normal development aging 13-months, a radiographic examination of the forelimb (carpus) was performed on both cats. There was lack of growth plate fusion in the patient, without any other evidence of dysgenesis, whereas complete epiphyseal closure was observed in the sibling. Despite therapeutic prescriptions of desmopressin and levothyroxine, the owners refused further follow-up to the...(AU)

Diabetes insipidus central em felino jovem / Central diabetes insipidus in a young feline

Background: Central diabetes insipidus (CDI) is an endocrine disorder caused by the failure to produce, transport, orrelease ADH. This disease may show a primary etiology (idiopathic or congenital) or a secondary one (trauma or neoplasms). It is characterized by signs such as polyuria and polydipsia. The definitive diagnosis is obtained by the two-stepwater deprivation test; the absence of adequate urinary concentration in the first stage confirms the diagnosis of diabetesinsipidus and, in the second stage, the response to the application of synthetic desmopressin confirms a central origin.Because CDI is rare in felines, the aim of this study was to report the occurrence of a case of CDI, probably of congenitalprimary origin, in an 8-month-old kitten.Case: An 8-month-old male feline, castrated, 3.2 kg, was brought to consultation with a report of polydipsia, polyuria,smaller size and weight, and lower activity when compared to his brother, for several months. On physical examination,lethargy, body score 2/5, and mild dehydration were noted, as well as deciduous teeth that should have already been replaced. Abdominal ultrasound and laboratory tests were requested, which ruled out chronic kidney disease (CKD), diabetesmellitus (DM), hyperadrenocorticism (HAC), and hyperthyroidism. Due to the fact that urinalysis evidenced hyposthenuria(urinary density [UD] 1.004), CDI was suspected. The patient underwent a water deprivation test and, after 7.5 h, lost4.7% of his initial weight, while UD was 1.012, confirming the diagnosis of DI. The investigation then proceeded to theevaluation of the response to synthetic desmopressin by the application of 5 U IM. Two h later, UD was 1.019, confirming...(AU)

Diabetes insipidus central em felino jovem / Central diabetes insipidus in a young feline

Background: Central diabetes insipidus (CDI) is an endocrine disorder caused by the failure to produce, transport, orrelease ADH. This disease may show a primary etiology (idiopathic or congenital) or a secondary one (trauma or neoplasms). It is characterized by signs such as polyuria and polydipsia. The definitive diagnosis is obtained by the two-stepwater deprivation test; the absence of adequate urinary concentration in the first stage confirms the diagnosis of diabetesinsipidus and, in the second stage, the response to the application of synthetic desmopressin confirms a central origin.Because CDI is rare in felines, the aim of this study was to report the occurrence of a case of CDI, probably of congenitalprimary origin, in an 8-month-old kitten.Case: An 8-month-old male feline, castrated, 3.2 kg, was brought to consultation with a report of polydipsia, polyuria,smaller size and weight, and lower activity when compared to his brother, for several months. On physical examination,lethargy, body score 2/5, and mild dehydration were noted, as well as deciduous teeth that should have already been replaced. Abdominal ultrasound and laboratory tests were requested, which ruled out chronic kidney disease (CKD), diabetesmellitus (DM), hyperadrenocorticism (HAC), and hyperthyroidism. Due to the fact that urinalysis evidenced hyposthenuria(urinary density [UD] 1.004), CDI was suspected. The patient underwent a water deprivation test and, after 7.5 h, lost4.7% of his initial weight, while UD was 1.012, confirming the diagnosis of DI. The investigation then proceeded to theevaluation of the response to synthetic desmopressin by the application of 5 U IM. Two h later, UD was 1.019, confirming...

Evidence of pituitary hypoplasia associated with partial central diabetes insipidus in a young Persian cat

Background: Congenital anomalies are an uncommon pituitary hypofunction cause associated to multiple hormone deficiencies. Congenital hyposomatotropism is often related to an inherited anomaly, characterized mainly by delayed growth. It is not uncommon to find associated thyroid-stimulating hormone and gonadotropin deficiencies. Pituitary malformation may be associated to progressive cystic lesion expansion. Central diabetes insipidus (CDI) is another rare disease associated to polyuria (PU) and polydipsia (PD) secondary to antidiuretic hormone (ADH) deficient secretion. The aim of this report is to describe a likely case of pituitary hypoplasia, associated with partial CDI in a cat. Case: A 9-month-old unneutered male Persian cat weighing 2 kg was presented due to severe polyuria and polydipsia associated with growth deficit when compared with its sibling. After clinical and laboratory evaluations during the months in which the patient was monitored, reduced serum concentration of insulin-like growth factor-1 (IGF-1), thyroid-stimulating hormone (TSH), thyroid hormones, and testosterone were documented, confirming the diagnosis of hyposomatotropism, hypogonadism, and secondary hypothyroidism. Furthermore, therapeutic diagnosis with desmopressin revealed partial central diabetes insipidus (CDI). As the sibling showed normal development aging 13-months, a radiographic examination of the forelimb (carpus) was performed on both cats. There was lack of growth plate fusion in the patient, without any other evidence of dysgenesis, whereas complete epiphyseal closure was observed in the sibling. Despite therapeutic prescriptions of desmopressin and levothyroxine, the owners refused further follow-up to the...

Diabetes insipidus central em um gato: relato de caso / Central diabetes insipidus in a cat: case report

O diabetes insípidus é uma enfermidade rara nos animais domésticos caracterizada por uma intensa poliúria e polidipsia secundária. Um gato foi examinado com a principal queixa de poliúra e polidipsia. O diagnóstico de diabetes insipidus central foi baseado em uma hipostenúria persistente com incapacidade de concentrar urina em resposta à privação hídrica e numa resposta positiva após a administração exógena do hormônio antidiurético. O tratamento com a DDAVP (1 desamino-8-D-arginina vasopressina) administrado no saco conjuntival a cada 12 horas controlou os sintomas

Diabetes insipidus is a rare disease of animals characterized by diuresis of dilute urine, with secondary polydipsia. A 1 year-old, male cat was presented for examination because polyuria and polydipsia. Central diabetes insipidus was diagnosed, based on persistent hyposthenuria with failure to concentrate urine in response to water deprivation and positive response to antidiuretic hormone administration. Treatment with DDAVP (1 desamino-8-D-arginine vasopressin) given in the conjunctival sac every 12 hours controlled the symptoms

Diabetes insipidus central em um gato: relato de caso / Central diabetes insipidus in a cat: case report

O diabetes insípidus é uma enfermidade rara nos animais domésticos caracterizada por uma intensa poliúria e polidipsia secundária. Um gato foi examinado com a principal queixa de poliúra e polidipsia. O diagnóstico de diabetes insipidus central foi baseado em uma hipostenúria persistente com incapacidade de concentrar urina em resposta à privação hídrica e numa resposta positiva após a administração exógena do hormônio antidiurético. O tratamento com a DDAVP (1 desamino-8-D-arginina vasopressina) administrado no saco conjuntival a cada 12 horas controlou os sintomas(AU)

Diabetes insipidus is a rare disease of animals characterized by diuresis of dilute urine, with secondary polydipsia. A 1 year-old, male cat was presented for examination because polyuria and polydipsia. Central diabetes insipidus was diagnosed, based on persistent hyposthenuria with failure to concentrate urine in response to water deprivation and positive response to antidiuretic hormone administration. Treatment with DDAVP (1 desamino-8-D-arginine vasopressin) given in the conjunctival sac every 12 hours controlled the symptoms(AU)

Experimental intoxication by the mushroom Ramaria flavo-brunnescens in sheep.

Ramaria flavo-brunnescens collected in autumn from 1990 to 1994 was orally administered to 11 sheep. These animals were dosed with 100-430 g/kg bw administered over 3-13 d. Six sheep showed clinical signs and 4 of them died. The mininum toxic dose was of 150 g/kg bw. Clinical signs were anorexia, hyperthermia, dyspnea, polyuria, ataxy, muscle tremors and seizures. The eyes had hyperemia of the sclera and, in some cases, hemorrhages of the anterior chamber or corneal opacity. Sheep dosed with higher doses had ulcerations of the tongue and necrotic lesions in the hooves. The main histologic lesions of the feet and tongue were miopachynsis and endotelial degeneration followed by degeneration, necrosis and ulceration of the epithelium. Hemorrhages of the anterior chamber, and severe congestion and hemorrhages of the iris, ciliary body and process were observed in the eyes. Congestion and perivascular hemorrhages occurred in the central nervous system. The similarity of clinical signs and pathologic lesions induced by R flavo-brunnescens and those caused by ergotism in cattle and sheep suggests the presence ofa vasoactive constrictive substance in the mushroom. Fresh R flavo-brunnescens dosed in autumn 1993 was not toxic at doses of 200-400 g/kg demonstrating variations in the toxicity of the mushroom from year to year.