Ectopic tooth in maxillary sinus compressing the nasolacrimal canal: A case report.

RATIONALE: Ectopic tooth is tooth erupting out of normal anatomical position. Ectopic tooth can occur in different positions, such as maxillary sinus and nasal cavity. In this article, we present a rare case of an ectopic tooth with a dentigerous cyst in the maxillary sinus compressing the nasolacrimal canal. PATIENT CONCERNS: An 8-year-old girl presented with a 2-month history of spontaneous lacrimation in her right eye. When she wept, more tear shed from her right eye than that from the left one. Computed tomographic (CT) imaging showed a huge low-density image containing a tooth in the maxillary sinus in her right maxilla; the right nasolacrimal canal vanished due to the compression of the ectopic tooth. DIAGNOSES: Ectopic tooth with dentigerous cyst of right maxilla, and obstruction of nasolacrimal duct. INTERVENTIONS: The patient underwent nasal endoscopic maxillary sinus cystectomy. OUTCOMES: The patient recovered well after cystectomy and has been symptom-free. LESSONS: The unique finding is that this is the first report about ectopic tooth compressing the nasolacrimal canal and inducing spontaneous lacrimation. Treatment: aspect: surgery under endoscope is a minimally invasive approach to ectopic tooth.

Dentigerous cyst formation following trauma to the primary incisors: A case report.

Although usually considered to be of developmental origin, dentigerous cysts (DCs) have been reported to form in response to chronic periapical inflammation associated with primary teeth that have necrotic, infected pulps. This article describes the management of a DC associated with tooth 21 in a seven-year-old Caucasian child with a history of multiple TDIs to the primary maxillary incisors. Chronic periapical inflammation associated with a necrotic pulp in tooth 61 was identified as the likely cause of the lesion. Initial conservative management involved marsupialization of the lesion by extracting the necrotic tooth 61. Following significant decompression of the cyst, surgical enucleation was carried out under general anaesthesia and an orthodontic attachment was bonded to the crown of the unerupted tooth 21 to facilitate traction. Histopathological assessment of the enucleated tissue confirmed it to be a DC. Two years after the initial presentation, teeth 21 and 22 had erupted into the oral cavity, improving patient aesthetics. However, the root of tooth 22 was transposed with the crown of the unerupted tooth 23. This case highlights the undesirable sequelae that may occur following delayed and inappropriate management of TDIs.

Marsupialização de cisto dentígero após traumatismo / Marsupialization of dentigerous cyst after traumatism

Objetivo: as causas mais comuns das alterações na dentição permanente são os traumatismos alvéolo-dentários (TAD) na dentição decídua, ultrapassando, inclusive, as incidências de cárie ou doença periodontal. Estes podem levar a hipoplasia de esmalte, alterações na morfologia dentária e desenvolvimento de cistos, como o cisto dentígero, considerando ainda que o tratamento desta ocorrência diverge ao tratar da dentição decídua e não da permanente. O objetivo deste trabalho é ilustrar essas características e como elas podem ser manejadas através de um relato de caso. Relato de caso: no caso em questão, ocorreu o desenvolvimento de um cisto dentígero de grandes dimensões após traumatismo alvéolo-dentário em dentição decídua na região anterior da maxila com retenção de três dentes permanentes. Foram discutidas as formas terapêuticas para tal situação clínica, bem como a possibilidade de uma abordagem multidisciplinar da cirurgia-ortodontia. Considerações finais: os TADs na dentição decídua devem ser bem diagnosticados e tratados, visando a prevenção de sequelas na dentição permanente.(AU)

Objective: the most common causes of changes in permanent dentition are alveolar-dental trauma (TAD) in deciduous dentition, with occurrence rates even higher than decays or periodontal disease, which can lead to enamel hypoplasia, changes in dental morphology and the development of cysts such as the dentigerous cyst, considering treatment differs when dealing with deciduous dentition instead of permanent dentition. The objective of this work is to illustrate these characteristics and propose a possible treatment, through a case report. Case report: in the case at hand occurred a development of a large dentigerous cyst occurred after TAD in primary dentition, in the anterior region of the maxilla with retention of three permanent teeth, discussing the therapeutic forms for such clinical situation, as well as the possibility of a multidisciplinary approach to surgery-orthodontics. Final considerations: TAD in deciduous teeth should be well diagnosed and treated aiming to prevent sequelae in permanent dentition.(AU)

Bilateral Mandibular Dentigerous Cysts Presenting as an Incidental Finding: A Case Report.

BACKGROUND Dentigerous cysts are slow-growing odontogenic cysts that usually develop unilaterally as part of a pre-existing syndrome. Non-syndromic bilateral dentigerous cysts are extremely rare, but clinicians should be aware of this condition to ensure prompt diagnosis and management and to prevent complications. CASE REPORT A case is presented of bilateral mandibular dentigerous cysts that were discovered incidentally in a 44-year-old man who presented for extraction of a retained maxillary deciduous tooth. Histological examination of the tissue specimens following bilateral enucleation confirmed the diagnosis of bilateral dentigerous cysts. CONCLUSIONS In this case, incidental bilateral dentigerous cysts were identified and treated by enucleation. The absence of an associated syndrome should not exclude the possibility of the diagnosis of dentigerous cysts, which should be removed to prevent future complications.

Tratamiento quirúrgico de quistes dentígeros asociados a terceros molares: presentación de dos casos clínicos y revisión de la literatura / Surgical treatment of dentigerous cysts associated to third molars: two case reports and a literature review

Introducción. El quiste dentígero es un quiste odontógeno del desarrollo de origen epitelial, siendo el más común después del radicular. Generalmente se asocia con la corona de dientes permanentes impactados o no erupcionados y su aparición es más frecuente en varones durante la segunda década de la vida. Los dientes que suelen verse más afectados son los terceros molares mandibulares, seguido de los caninos maxilares. A causa de su curso asintomático, el diagnóstico suele realizarse por hallazgo casual en radiografías panorámicas rutinarias. Para el diagnóstico definitivo es indispensable la realización de la anatomía patológica. Caso clínico. Se presenta el caso clínico de dos mujeres de 60 y 42 años de edad, sin antecedentes médicos de interés, remitidas al servicio de Cirugía Bucal del hospital Virgen de la Paloma, presentando una imagen radiográfica radiotransparente asociada a la corona del tercer molar inferior izquierdo sin sintomatología asociada. Tras realizar la extracción quirúrgica de los cordales afectados y la lesión quística asociada, se obtiene el diagnóstico definitivo mediante la anatomía patológica, posteriormente se realizan controles clínicos y radiográficos de la zona. Conclusiones. El quiste dentígero representa el segundo quiste odontógeno más frecuente después del quiste radicular en terceros molares retenidos. Es importante el examen radiográfico periódico de terceros molares incluidos para el diagnóstico y tratamiento de esta entidad patológica (AU)

Introduction. A dentigerous cyst or follicular cyst is defined as a developmental odontogenic cyst of an epitelial origin which represents the second most common entity after the radicular cyst. Generally it is associated with the crown of a permanent unerupted tooth (or semi-erupted) and it tends to be more frequent in males during the second decade of life. The most common location of dentigerous cyst are mandibular third molars followed by the maxillary canines. Due to its asymptomatic behaviour, the diagnosis is reached by routine panoramic radiography, however, the anatomopathologic analysis will define its nature. Case Report. A case report of a 42 and 60 year old females with no medical history of interest, referred to the Oral Surgery Service of the hospital Virgen de la Paloma with a radiotransparent images surrounding the crown of the lower left third molar without associated symptoms. After the extraction of the teeth, cystic lessions are sent for anatomopathological study, which confirm the presumption diagnosis, dentigerous cyst. Patients carried out posterior follow ups sho-wing a positive healing of the bone around the surgical area. Conclusions. Dentigerous cyst represents the second most frequent odontogenic cyst after the radicular cyst at mandibular third lower molars. It is essential to monitor retained mandibular lower third molars for the incipient approach of the pathology (AU)

Angiogenesis concept in odontogenic keratocyst: A comparative study.

CONTEXT: Recent reports have indicated that angiogenesis possibly affects the biologic behavior of the lesions. AIM: Given the different clinical behaviors of odontogenic keratocyst (OKC), the present study was undertaken to evaluate the concept of angiogenesis in pathogenesis and clinical behavior of OKC. SETTING AND DESIGN: This experimental study was carried out on 22 and 24 samples of OKCs and dentigerous cysts (DCs), respectively. METHODS: Immunohistochemical staining was approached using CD34 and vascular endothelial growth factor (VEGF) antibodies. The expression of VEGF was first reported by determining the counts of stained cells, including epithelial cells, fibroblasts, and endothelial cells, followed by the percentage of stained cells in each sample based on a 0-2 scoring system. The counts of CD34+ cells were reported in each group in the form of means ± standard deviations. In addition, the patterns of blood vessels in the samples prepared from the walls of both cysts were evaluated. STATISTICAL ANALYSIS USED: Mann-Whitney U-test, Chi-squared test, and t-test were used for analysis of data, and statistical significance was defined at p < 0.05. RESULTS: The expression percentage and scores of VEGF and the mean expression rate of CD34 were significantly higher in OKCs than DCs (p = 0.045, 0.000, and p = 0.58). Finally, there was a strong correlation between the expressions of the two markers in the samples (Correlation coefficient = 0.766). CONCLUSION: The present results indicate the angiogenesis may play an important role in the pathogenesis and the unique clinical behavior of OKC.

Inflammatory dentigerous cyst of mandibular first premolar associated with endodontically treated primary first molar: a rare case report.

AIM: Inflammatory dentigerous cysts usually occur in the mixed dentition. It has been reported that inflammatory lesions from the root area of a deciduous tooth bring about the development of dentigerous cysts around the unerupted permanent tooth bud. Endodontic treatment is a common and successful procedure for periapical inflammation in children. An inflammatory dentigerous cyst can occur in conjunction with endodontically treated primary tooth. CASE REPORT: This article reports a case of 6 years and 6 months old boy, with a single, well-defined, unilocular, radiolucent area enclosing the first right unerupted mandibular premolar, accidentally discovered on the panoramic radiograph. The first right primary molar had received a root canal treatment 18 months prior. Clinical findings combined with radiographic and microscopic examinations confirmed the diagnosis of inflammatory dentigerous cyst. As treatment, enucleation of the cyst with removal of the involved permanent tooth was chosen and a removable partial denture was supplied to the patient after surgery. The 5-year follow-up revealed good healing of the bony lesion and displaced teeth. CONCLUSION: This case presented a severe and rare complication of endodontically treated primary tooth, and the recommendation includes: (1) early diagnosis of dentigerous cysts, which is essential to prevent extensive treatment; (2) more information on the adverse side effects of an endodontic treatment should be given to patients and parents; (3) patients should be informed about the importance of follow-ups and radiographic follow-up should be routinised.

Kissing molars: report of three cases and new prospective on aetiopathogenetic theories.

Kissing molars (KMs) is an extremely rare condition of impacted third molars, pointed in the opposite direction in a single follicular space; it consists exactly in a full impacted of permanent molars which occurs only in the lower jaw. Actually, about less than thirty cases have been reported in scientific literatures. The aetiology and pathogenesis of this pathological double dental inclusion remain unknown; above all events that lead two molars to appear, as KMs remain mysterious. The association to metabolic connective diseases such as mucopolysaccharidosis was emphasized. KMs considered as an isolated event, may be associated to an abnormal position of the tooth-bud from lower permanent molars, or fourth supernumerary tooth (distomolar). Recently, hyperplastic dental follicle (HDF), with a down regulation of matrix metal-proteinases and up regulation of several genes of collagens, has been mentioned in association with KMs. In this paper, after having analyzed three new cases of KMs that have been treated, we report a new hypothesis. This last is based on the failure in the dental follicle's ability to initiate or continue properly resorption of the overlying alveolar bone, by many exogenous factors which may act on eruptive phase that would lead to its rotation with its contents coming out a pathological situation of KMs. The therapy of choice is related to the surgical removal of KMs through a double odontectomy with transalveolar method. Other treatments can be, eventually, orthodontic therapy of the impacted teeth and a radiological follow-up without surgery.

[Large dentigerous cyst caused by retained tooth 25]. / Duza torbiel zawiazkowa spowodowana zatrzymanym zebem 25.

Follicular cysts are benign, non-inflammatory odontogenic cysts, usually painless and discovered during routine radiographic examination. The article describes a case of a large follicular cyst with retained tooth 25. Pantomographic x ray showed the presence of a large follicular cyst located on the side of the impacted 25 tooth. The cyst has been enucleated and the tooth extracted surgically with subsequent closure of oro-antral communication. After 3 months orthodontic treatment was initiated.

Dentigerous cyst of inflammatory origin.

There is an association between persistent, prolonged inflammation of a primary tooth and the development of an inflammatory dentigerous cyst involving the succedaneous tooth. The purpose of this case report is to describe the management of an inflammatory dentigerous cyst of the permanent maxillary left central incisor in a nine-year-old boy caused by a long-term inflammation/infection of its predecessor. The treatment consisted of conservative decompression, which allowed for rapid healing and the eruption of the permanent tooth. The patient was followed up with periodic clinical and radiographic evaluations for several years.

An idiosyncratic post-traumatic tetrad: compound odontome, dentigerous cyst, impaction, and double-dilaceration.

OBJECTIVE: This report describes the case of a 13-year-old patient who experienced traumatic intrusion of the primary maxillary right central incisor and subsequently suffered an atypical tetrad, comprising of an unerupted compound odontoma associated with a dentigerous cyst, and an impacted, doubly dilacerated permanent maxillary right central incisor; however, the high interconnectivity of the occurrence of four pathologies together is unusual has not previously been reported. SUMMARY: The pathologies were detected 7 years after trauma; surgical removal of odontome along with the dentigerous cyst was performed, followed by orthodontic extrusion of the impacted double-dilacerated permanent central incisor. The 18-month follow-up shows no pathology, no gingival recession, and normal probing depth.

[Dentigerous cyst in a pediatric patient with acute lymphoblastic leukemia type 1]. / Quiste dentígero en un niño con leucemia linfoblástica aguda tipo 1.

OBJECTIVE: To report medical and surgical treatment in a patient with acute lymphoblastic leukemia type 1 who developed a dangerous cyst. CLINICAL CASE: A male of 8 years with acute lymphoblastic leukemia type 1, whose treatment was in induction. In one month, the patient presented a facial asymmetry due to mandibular growth and acute pain, hyperthermia and malaise. In the examination, we identified lip parestesia, a second temporal molar treated with chromium steel and expansion involving the cortical of the lateral permanent incisive until the first permanent molar was identified. Since we suspected of bone metastasis, we performed an orthopantomography. We established the diagnosis of dentigerous cyst. Enucleation, curettage, and extraction of decay teeth were done in order to avoid and prevent infectious sources. CONCLUSIONS: The most frequent clinical manifestations of acute lymphoblastic leukemia are anemia, leukopenia, and thrombocytopenia. This leukemia may be manifested also as infiltration of the jaw bone. In this case, the results showed no presence of bone metastasis. As a first step before to begin treatment, the physician ought to make sure that the patient is free of infectious processes anywhere that may influence the clinical development of leukemia. Due to the surgical intervention and to a successful bone marrow transplant, the patient is on remission.

OBJETIVO: describir el tratamiento médico-quirúrgico en un niño con leucemia linfoblástica aguda tipo 1 que desarrolló un quiste dentígero. CASO CLÍNICO: niño de ocho años de edad con leucemia linfoblástica aguda, cuyo tratamiento estaba en fase de inducción. En el transcurso de un mes, el niño presentó asimetría facial por aumento de la mandíbula, así como dolor agudo, hipertermia y malestar general. A la exploración se identificó parestesia labial, segundo molar temporal con restauración de corona de acero cromo y expansión de la cortical del incisivo lateral permanente hasta primer molar permanente. Por sospecha de metástasis ósea se realizó una ortopantomografía con la que se estableció el diagnóstico de quiste dentígero. Se realizó enucleación, curetaje y extracción de órganos dentarios cariados para prevenir infecciones. CONCLUSIONES: las manifestaciones clínicas más frecuentes de la leucemia linfoblástica aguda suelen ser anemia, trombocitopenia, leucopenia y ocupación de la médula ósea por blastos. También puede manifestarse con infiltrado óseo en mandíbula; en el paciente descrito no se demostró metástasis ósea. Antes de iniciar el tratamiento de la leucemia linfoblástica aguda, se debe verificar que los pacientes estén libres de fuentes de infección que pudieran influir en su evolución. Debido a la intervención quirúrgica oportuna y al trasplante autólogo de médula, al momento de este informe el paciente se encontraba en remisión.

Endodontic therapy of a mandibular canine tooth with irreversible pulpitis secondary to dentigerous cyst.

Dentigerous cysts are uncommon, yet are being reported with increasing frequency in the veterinary literature. Dentigerous cysts are a type of benign odontogenic cyst associated with impacted teeth, most commonly the mandibular first premolar tooth. Significant bone destruction can occur secondary to the expansion of a dentigerous cyst. The expanding cyst can lead to pathology of neighboring teeth, which can include external root resorption or pulpitis. Intraoral dental radiographs are imperative to properly assess the presence and extent of a dentigerous cyst, as well as the status of the neighboring teeth. This case report describes treatment for dentigerous cyst including cyst lining curettage, mandibular bone regeneration, and endodontic therapy for a canine tooth with irreversible pulpitis.

Imunoexpressão do EGFR e da PODOPLANINA em cistos radiculares e dentígeros / Immunostaining of EGFR and podoplanin in radicular cysts and dentigerous

Os cistos radiculares (CRs) e dentígeros (CDs), apesar de possuírem etiologias diferentes, formam uma cavidade patológica revestida por epitélio, a qual cresce em função do acúmulo de líquido em seu interior, à medida que o osso ao redor é reabsorvido e o epitélio vai sendo induzido a proliferar. A proliferação epitelial, que tem sido apontada como um dos processos determinantes no crescimento das lesões císticas odontogênicas, é influenciada por fatores de crescimento como o EGFR (receptor do fator de crescimento epidérmico) e a podoplanina (PDPN), muitos dos quais podem ter sua produção estimulada principalmente durante processos inflamatórios. O objetivo desta pesquisa foi avaliar e comparar a expressão imunoistoquímica do EGFR e da PDPN em 30 casos de CRs e 30 casos de CDs, de forma semiquantitativa, em microscopia de luz, associando-a com o grau de inflamação, localização celular da imunocoloração e com as camadas epiteliais imunomarcadas. Os dados foram avaliados estatisticamente por meio de testes do Qui-quadrado e Exato de Fisher, considerando-se um nível de significância de 5%. Os resultados mostraram que houve elevada imunorreatividade das duas proteínas nas lesões estudadas, sendo observada apenas diferença estatística significativa na imunoexpressão da PDPN (p=0,033), que se mostrou mais elevada nos CRs. Os demais parâmetros analisados não demonstraram diferenças significativas relevantes. Conclui-se que, como o EGFR e a PDPN apresentaram elevada imunoexpressão nas lesões císticas analisadas, essas proteínas participam da patogênese dessas lesões através da estimulação epitelial, apesar de apresentarem etiologias diferentes. Além disso, pode-se inferir que a maior imunomarcação da PDPN em CRs do que em CDs não se mostrou indicador de distinção entre as duas lesões, com relação às suas etiologias, uma vez que nestes últimos essa proteína também apresentou expressão considerável, independente da intensidade do infiltrado inflamatório. (AU)

The radicular cysts (RCs) and dentigerous (DCs), despite having different etiologies, form a pathological cavity lined by epithelium, which grows due to the buildup of fluid inside, as the surrounding bone is reabsorbed and the epithelium will being induced to proliferate. The epithelial proliferation, which has been identified as one of the key processes in the growth of odontogenic cystic lesions, is influenced by growth factors such as EGFR (epidermal growth receptor factor) and podoplanin (PDPN), many of which may have its production stimulated mainly during inflammatory processes. The objective of this research was to evaluate and compare the immunohistochemical expression of EGFR and PDPN in 30 cases of RCs and 30 cases of DCs, semiquantitatively, in light microscopy, associating it with the degree of inflammation, cellular localization of immunostaining and with the immunostained epithelial layers. Data were statistically analyzed by Chi-square test and Fisher exact test, considering a significance level of 5 %. The results showed high immunoreactivity of both proteins in the lesions studied, only statistically significant difference was observed in immunostaining of PDPN (p=0.033), which proved higher in RCs. The other analyzed parameters showed no relevant significant differences. We conclude that, as EGFR and PDPN showed high immunoreactivity in cystic lesions analyzed, these proteins participate the pathogenesis of these lesions through the epithelial stimulation process, despite having different etiologies. Furthermore, it can infer that the higher immunostaining of PDNP in RCs that DCs showed no distinction indicator between the two lesions, regarding their etiologies, once this protein also showed a considerable expression in DCs, independent of the intensity of the inflammatory infiltrate. (AU)

Anomalous morphology of an ectopic tooth in the maxillary sinus on three-dimensional computed tomography images.

We describe a case of an incidentally-diagnosed ectopic tooth showing anomalous morphology in the maxillary antrum, using three-dimensional reconstruction of computed tomography images of the tooth obtained by multi-detector computed tomography.