RESUMEN
Sn(II) binds to kaempferol (HKaem, 3,4',5,7-tetrahydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one) at the 3,4-site forming [Sn(II)(Kaem)2] complex in ethanol. DPPH⢠scavenging efficiency of HKaem is dramatically decreased by SnCl2 coordination due to formation of acid inhibiting deprotonation of HKaem as ligands and thus reduces the radical scavenging activity of the complex via a sequential proton-loss electron transfer (SPLET) mechanism. Moderate decreases in the radical scavenging of HKaem are observed by Sn(CH3COO)2 coordination and by contact between Sn and HKaem, in agreement with the increase in the oxidation potential of the complex compared to HKaem, leading to a decrease in antioxidant efficiency for fruits and vegetables with Sn as package materials.
Asunto(s)
Depuradores de Radicales Libres/química , Depuradores de Radicales Libres/farmacología , Quempferoles/química , Quempferoles/farmacología , Radioisótopos de Estaño/química , Cinética , Estructura Molecular , Análisis EspectralRESUMEN
Batch experiments were performed to study adsorption and desorption of 75Se and 113Sn radiotracers at environmentally representative concentrations of ~0.3 ng L-1 and ~3 ng L-1, respectively. The radiotracers were incubated with wet bulk sediments from the Gironde Estuary and the Rhône River, combining freshwater and coastal seawater salinity (S = 0, S = 32) and three different Suspended Particulate Matter (SPM) concentrations (10 mg L-1, 100 mg L-1, 1000 mg L-1) to simulate six hydrologically contrasting situations for each particle type. Results showed no measurable adsorption for 75Se under the experimental conditions, whereas >90% of 113Sn rapidly adsorbed onto the particles during the first hours of exposure. Adsorption efficiency increased with increasing SPM concentration and seemed to be slightly greater for the Rhône River sediments, potentially related to the intrinsic mineral composition. Desorption of spiked sediments exposed to filtered, unspiked freshwater and seawater only occurred for 113Sn (<15% of the previously adsorbed 113Sn) in the Garonne River sediments. This study provides insights to the potential environmental behaviour of hypothetical radionuclide releases of Se and Sn into highly dynamic and contrasting aquatic systems. Multiple accidental scenarios for the case of the Gironde Estuary and the Rhône River are discussed. These scenarios suggest that the environmental fate of soluble radionuclides like Se will be associated to water hydrodynamics and potentially more bioavailable whereas highly particle-active radionuclides like Sn will follow natural river/estuarine sedimentary regimes. Information on reactivity of radionuclides is important for improving the precision of current approaches aiming at modelling environmental radionuclide dispersion in continent-ocean transition systems.
Asunto(s)
Monitoreo de Radiación , Salinidad , Contaminantes Químicos del Agua , Adsorción , Monitoreo del Ambiente , Sedimentos Geológicos , Cinética , Ríos , Radioisótopos de Selenio , Radioisótopos de EstañoRESUMEN
The interaction of Sn(II) with metastable, highly reactive mackinawite is a complex process due to transient changes of the mackinawite surface in the sorption process. In this work, we show that tin redox state and local structure as investigated by Sn-K X-ray absorption spectroscopy (XAS) change with pH. We observe at pH<7 that divalent Sn forms two short (2.38 Å) Sn-S bonds to the S-terminated surface of mackinawite, and two longer (2.59 Å) Sn-S bonds pointing most likely towards the solution phase, in line with a SnS4 innersphere sorption complex. Precipitation of SnS or formation of a solid solution with mackinawite could be excluded. At pH>9, Sn(II) is completely oxidized to Sn(IV) by an Fe(II)/Fe(III) (hydr)oxide, most likely green rust, forming on the surface of mackinawite. Six O atoms at 2.04 Å and 6 Fe atoms at 3.29 Å indicate a structural incorporation by green rust, with Sn(IV) substituting for Fe in the crystal structure. The transition between Sn(II) and Sn(IV) and between sulfur and oxygen coordination takes place at a pH of 7 to 8 and an Eh of -250 mV, close to the thermodynamically predicted transitions from mackinawite to Fe (hydr)oxide and from sulfide to sulfate. The uptake processes of Sn(II) by mackinawite are largely in line with the uptake processes of divalent cations with soft Lewis-acid character like Cd, Hg and Pb, and lead to a strong retention of Sn with logRd values from 5 to 7 across the investigated pH range of 5 to 11.
Asunto(s)
Compuestos Ferrosos/química , Estaño/química , Concentración de Iones de Hidrógeno , Oxidación-Reducción , Oxígeno/química , Soluciones/química , Sulfuros/química , Azufre/química , Radioisótopos de Estaño/química , Espectroscopía de Absorción de Rayos X/métodosRESUMEN
UNLABELLED: Deposition of an acid-resistant barrier onto enamel represents a potentially superior means for delivering protection against dietary, erosive acid challenges. PURPOSE: The purpose of this study was to demonstrate the ability of a stabilised stannous fluoride (SnF2 ) dentifrice to: (1) deposit a SnF2 barrier layer onto pellicle-coated enamel surfaces; (2) increase the intensity of the barrier layer over time; and (3) be retained on the enamel surface for hours after product use. METHODS: Squares of human enamel were exposed to pooled saliva for 1 hour (pellicle formation) and separated into six sets. Set 1 was treated with the supernatant of a 1:3 slurry of the test dentifrice (Crest(®) Pro-Health(®) : water for 2 minutes), then rinsed. Set 2 was treated in the same manner and then placed into saliva (6 hours). Set 3 was cycled through seven repeated treatments. Set 4 was treated for seven cycles and then placed into saliva (6 hours). Set 5 was a water control, and set 6 was a water control that remained in saliva for 6 hours. Surface analysis of specimens was done using laser ablation Inductively Coupled Plasma Mass Spectroscopy (ICP-MS). RESULTS: Deposition of a barrier layer was demonstrated, beginning with the initial treatment, with Sn (using isotopes (117) Sn + (120) Sn) measured on the enamel surface as the reference marker. Deposition of the barrier layer was greater after seven cycles, and the retention of this layer was highly significant (P = 0.05, anova: 6 hours). CONCLUSIONS: This study confirms that: (1) the stabilised SnF2 dentifrice deposits a barrier layer onto the enamel surface, beginning with the first use of the product; (2) this barrier is enhanced following multiple treatments; and (3) the barrier layer is retained on the enamel surface for hours after product use.
Asunto(s)
Esmalte Dental/metabolismo , Película Dental/metabolismo , Fluoruros de Estaño/farmacocinética , Esmalte Dental/química , Película Dental/química , Dentífricos/análisis , Dentífricos/farmacocinética , Humanos , Isótopos , Láseres de Estado Sólido , Fosfatos/análisis , Fosfatos/farmacocinética , Sustancias Protectoras/análisis , Sustancias Protectoras/farmacocinética , Espectrofotometría Atómica/instrumentación , Espectrofotometría Atómica/métodos , Factores de Tiempo , Fluoruros de Estaño/análisis , Radioisótopos de Estaño , Agua/químicaRESUMEN
In the frame of a co-operation between CEA-LIST/LNE-LNHB (France) and IFIN-HH (Romania), the relative intensities of the photon emissions following the (113)Sn decay were accurately determined at the LNHB using high resolution X- and γ-ray spectrometers, characterized by excellent quality efficiency calibrations. Two series of measurements were carried out. The intensity of the 255 keV γ-ray relative to that of the 392 keV γ-ray was determined with an uncertainty lower than 1%. A new (113)Sn nuclear decay data evaluation was accomplished. The main results obtained are presented.
Asunto(s)
Radiometría/normas , Radioisótopos de Estaño/análisis , Radioisótopos de Estaño/química , Semivida , Internacionalidad , Fotones , Dosis de Radiación , Estándares de Referencia , Valores de ReferenciaRESUMEN
Treatment of multisite, sclerotic bone metastases is successfully performed by radionuclide therapy. Pain palliation is the most common aim for the treatment. Two radiopharmaceuticals are currently approved by the European Medicines Agency ((153)Sm-EDTMP and (89)Sr-Cl2) whilst other radiopharmaceuticals are at different stages of development, or are approved in some European countries ((186)Re-HEDP, (117)Snm-DTPA and (223)Ra-Cl2). The tissues at risk for the treatment are bone marrow and normal bone. A review of the methods applied for dosimetry for these tissues and for tumours is performed, including the calculation of S values (the absorbed dose per decay) and optimal procedures on how to obtain biodistribution data for each radiopharmaceutical. The dosimetry data can be used to individualise and further improve the treatment for each patient. Dosimetry for radionuclide therapy of bone metastases is feasible and can be performed in a routine clinical practice.
Asunto(s)
Neoplasias Óseas/radioterapia , Radiofármacos/administración & dosificación , Radiofármacos/uso terapéutico , Planificación de la Radioterapia Asistida por Computador/métodos , Neoplasias Óseas/metabolismo , Neoplasias Óseas/secundario , Humanos , Dolor/radioterapia , Cuidados Paliativos , Radioisótopos de Fósforo/administración & dosificación , Radiofármacos/efectos adversos , Radiofármacos/farmacocinética , Planificación de la Radioterapia Asistida por Computador/estadística & datos numéricos , Radio (Elemento)/administración & dosificación , Renio/administración & dosificación , Samario/administración & dosificación , Radioisótopos de Estroncio/administración & dosificación , Radioisótopos de Estaño/administración & dosificaciónRESUMEN
This paper deals with the experimental evaluation of the minimal detectable activity achievable by unfolding the gamma spectra of a NaI monitor. An aquatic monitor initially developed by the Institut des Radio-Eléments (IRE) is used for the application. Unfolding of the spectra is performed with GRAVEL, a UMG package code, on the basis of a response matrix obtained with MCNP5.1.40. Experimental data have been measured at IRE, in a 20m(3) seawater tank, for known activities of (137)Cs mixed with other gamma emitters ((40)K, (133)Ba, (113)Sn and (139)Ce). Deconvolution allows one to reduce the MDA of (137)Cs by an order of magnitude.
Asunto(s)
Radioisótopos de Cesio/química , Rayos gamma , Monitoreo de Radiación/instrumentación , Agua de Mar/química , Espectrometría gamma/instrumentación , Contaminantes Radiactivos del Agua/análisis , Radioisótopos de Bario/química , Radioisótopos de Cerio/química , Simulación por Computador , Radioisótopos de Potasio/química , Radiometría/instrumentación , Radioisótopos de Estaño/químicaRESUMEN
(113)Sn (115.09 d) is the parent nuclide of the (113)Sn/(113m)In generator system. (113m)In (99.476 min) is used in diagnostic nuclear medicine and as an Auger-electron emitter is a candidate for internal radiotherapy. Excitation functions of the (nat)In(d,x) (113 mg)Sn, (116 m)In, (ind115m)In, (114m)In, (ind113m)In, (cum111)In, (115g)Cd,(111m)Cd reactions were measured up to 40 MeV for the first time. The experimental results were compared with the curves calculated with the ALICE-D and EMPIRE-D theoretical model codes and curves given in the EAF-2007 and TENDL-2009 databases. Thick target yields, impurity levels and specific activities for the optimal energy range were deduced and compared with the same parameters of other charged particle production routes of (113)Sn.
Asunto(s)
Radioisótopos de Indio/química , Medicina Nuclear/métodos , Radioisótopos de Estaño/química , Deuterio/química , HumanosRESUMEN
In an attempt to elucidate the in vivo stability of the prospective radiopharmaceutical [(117m)Sn]Sn(IV)-PEI-MP, where PEI-MP stands for N,N',N'-trimethylenephosphonate-polyethyleneimine, glass electrode potentiometry was used to determine the stability constants of the Sn(4+) ion as complexed with a variety of physiological amino acids. In addition, linear free energy relationship (LFER) correlation plots were used to extrapolate the constants of the major blood plasma ligands, based on data from Cu(2+), Pb(2+), and Zn(2+). In so doing, a thermodynamic model of blood plasma was established for Sn(4+) from which the complexation tendencies of Sn(4+) were predicted in the event of the intravenous administration of such a drug. It was found that the Sn(IV)-PEI-MP could succumb to competition by the glutamine amino acid, which forms more stable complex(es), whilst the PEI-MP gets taken up largely by Ca(2+). Also, this study shows the value of the in vitro experiments and modeling performed for radiopharmaceutical research and for attempts to reduce the number of animal experiments.
Asunto(s)
Estabilidad de Medicamentos , Modelos Biológicos , Compuestos Orgánicos de Estaño/metabolismo , Radiofármacos/metabolismo , Radioisótopos de Estaño/metabolismo , Aminoácidos/sangre , Aminoácidos/metabolismo , Neoplasias Óseas/tratamiento farmacológico , Calcio/sangre , Calcio/metabolismo , Ácidos Carboxílicos/sangre , Ácidos Carboxílicos/metabolismo , Simulación por Computador , Bases de Datos Factuales , Glutamina/sangre , Glutamina/metabolismo , Humanos , Ligandos , Estructura Molecular , Compuestos Orgánicos de Estaño/sangre , Compuestos Orgánicos de Estaño/química , Potenciometría , Radiofármacos/sangre , Radiofármacos/química , Radioterapia , Radioisótopos de Estaño/sangre , Radioisótopos de Estaño/químicaRESUMEN
The BR2 reactor is a 100MW(th) high-flux 'materials testing reactor', which produces a wide range of radioisotopes for various applications in nuclear medicine and industry. Tin-117m ((117m)Sn), a promising radionuclide for therapeutic applications, and its production have been validated in the BR2 reactor. In contrast to therapeutic beta emitters, (117m)Sn decays via isomeric transition with the emission of monoenergetic conversion electrons which are effective for metastatic bone pain palliation and radiosynovectomy with lesser damage to the bone marrow and the healthy tissues. Furthermore, the emitted gamma photons are ideal for imaging and dosimetry.
Asunto(s)
Medicina Nuclear/instrumentación , Radioisótopos de Estaño/química , Electrones , Rayos gamma , Medicina Nuclear/métodos , Generadores de Radionúclidos , Radioisótopos de Estaño/uso terapéuticoRESUMEN
Organotin(IV) compounds of the type (o-MeE-C6H4)CH2SnPh3-nCln were synthesized, E = O, n = 0 (1), n = 1 (2), n = 2 (3) and E = S, n = 0 (4), n = 1 (5), n = 2 (6). The complexes exhibit significant trigonal bipyramidal pentacoordination at tin as a consequence of intramolecular Sn-O (1-3) and Sn-S (4-6) interactions upon substitution of the phenyl groups by chloro groups. The intramolecular Sn-O distances in 1, 2, and 3 are 83%, 75%, and 79% of the sum of the van der Waals radii. The equivalent Sn-S values for 4, 5, and 6 are 90%, 73%, and 71%, respectively. The geometry of compound 3 is complicated by intermolecular dimerization via bridging chlorines creating a distorted octahedral geometry at tin. The related dichloro sulfur compound 6 also exhibits an intermolecular association in the form of Sn-Cl-H hydrogen bonding leading to a polymeric structure in the solid state. CPMAS 119Sn NMR spectroscopy suggests that the intramolecular Sn-E interactions persist in solution and also facilitated the discovery of a new crystalline form of 4, 4', that contains a Sn-S distance which is 95% the sum of the van der Waals radii.
Asunto(s)
Calcógenos/química , Compuestos Orgánicos de Estaño/síntesis química , Cristalografía por Rayos X , Espectroscopía de Resonancia Magnética , Estructura Molecular , Oxígeno/química , Soluciones/química , Azufre/química , Estaño/química , Radioisótopos de Estaño , Difracción de Rayos XRESUMEN
Conditions for preparing Sn-EDTMP, Sn-DTPMP, Sn-TTHMP, Sn-HEDTMP and Sn-DTPA in aqueous solution in open air environments, and their in vitro properties including adsorption on hydroxyapatite (HA) and collagen (I) and binding to bovine serum albumin (BSA) were studied using (117m)Sn and 113Sn as tracers. Biodistributions of SnO2.xH2O.yEDTMP, SnO2.xH2O.yDTPMP, SnO2.xH2O.yTTHMP, SnO2.xH2O.yHEDTMP, SnO2.xH2O.yDTPA in normal mice were also tested. Based on the above experiments, the relationship between in vitro biochemical properties and biodistributions of these SnO2.xH2O.yLigands was investigated. The results show that Sn(IV)-Ligands are prone to hydrolysis into SnO2.xH2O.yLigands in aqueous solutions in open air environments, especially when the ligand is DTPA, when the molar ratio of metal to ligand is higher than 1:200, or when the pH of the solution is higher than 10. The in vitro experiments show that all of the SnO2.xH2O.yLigands bind strongly to BSA, and the binding percentages of SnO2.xH2O.yLigands to BSA are much higher than those of the corresponding Sn(IV)-Ligands. The biodistribution data indicate that all of the SnO2.xH2O.yLigands locate mainly in bone with little uptake in liver. When the binding percentages of SnO2.xH2O.yLigands to BSA are similar, those SnO2.xH2O.yLigands with higher adsorption on HA and collagen (I) undergo lower liver uptake.
Asunto(s)
Quelantes/química , Compuestos Organometálicos/química , Organofosfonatos/química , Radiofármacos/síntesis química , Radioisótopos de Estaño/química , Animales , Quelantes/síntesis química , Colágeno/química , Durapatita/química , Marcaje Isotópico/métodos , Ratones , Compuestos Organometálicos/síntesis química , Compuestos Organometálicos/farmacocinética , Radiofármacos/química , Radiofármacos/farmacocinética , Albúmina Sérica Bovina/química , Radioisótopos de Estaño/farmacocinética , Distribución TisularRESUMEN
In the search for a cure for metastatic bone cancer, 117mSn with its conversion electrons and low energy photons both of discrete energies shows little bone marrow toxicity, providing the opportunity to increase the administered dose. Selective accumulation in lesions would capitalise on this advantage. The 10-30 kDa fraction of the water-soluble polymer polyethyleneimine, functionalised with methyl phosphonate groups (PEI-MP) and labelled with 99mTc, has shown selective uptake into bone tumours. Furthermore using speciation calculations it was predicted that the Sn(II)-PEI-MP complex would remain intact in the blood plasma. Because of this positive indication animal experiments were carried out to test this prediction. This paper relates the labelling, biodistribution and pharmacokinetics of various fractions of 117mSn-(II) PEI-MP in the normal primate model, and points to promising therapeutic possibilities.
Asunto(s)
Neoplasias Óseas/radioterapia , Compuestos Orgánicos de Estaño/farmacocinética , Polietileneimina/farmacocinética , Radiofármacos/farmacocinética , Animales , Huesos/diagnóstico por imagen , Huesos/metabolismo , Peso Molecular , Compuestos Orgánicos de Estaño/sangre , Papio , Polietileneimina/análogos & derivados , Cintigrafía , Radiofármacos/sangre , Relación Estructura-Actividad , Medronato de Tecnecio Tc 99m , Radioisótopos de Estaño/sangre , Radioisótopos de Estaño/farmacocinética , Distribución TisularAsunto(s)
Analgesia/métodos , Neoplasias Óseas/secundario , Dolor/radioterapia , Cuidados Paliativos , Radiofármacos/uso terapéutico , Neoplasias Óseas/complicaciones , Neoplasias Óseas/radioterapia , Contraindicaciones , Costos de los Medicamentos , Predicción , Humanos , Dolor/etiología , Radioisótopos/uso terapéutico , Radiofármacos/administración & dosificación , Radiofármacos/economía , Renio/uso terapéutico , Samario/uso terapéutico , Radioisótopos de Estroncio/uso terapéutico , Radioisótopos de Estaño/uso terapéutico , Resultado del TratamientoRESUMEN
A rapid, accurate, sensitive, and simple method for simultaneous speciation analysis of mercury and tin in biological samples has been developed. Integrated simultaneous sample preparation for tin and mercury species includes open focused microwave extraction and derivatization via ethylation. Capillary gas chromatography-inductively plasma mass spectrometry (CGC-ICPMS) conditions and parameters affecting the analytical performance were carefully optimized both for species-specific isotope dilution analysis of MMHg and TBT and for conventional analysis of MBT and DBT201Hg-enriched monomethylmercury and 117Sn-enriched tributyltin were used for species-specific isotope dilution mass spectrometry (SIDMS) analysis. As important, accurate isotope dilution analysis requires equilibration between the spike and the analyte to achieve successful analytical procedures. Since the spike stabilization and solubilization are the most critical and time-consuming steps in isotope dilution analysis, different spiking procedures were tested. Simultaneous microwave-assisted spike stabilization and solubilization can be achieved within less than 5 min. This study originally introduces a method for the simultaneous speciation and isotope dilution of mercury and tin in biological tissues. The sample throughput of the procedure was drastically reduced by fastening sample preparation and GC separation steps. The accuracy of the method was tested by both external calibration analysis and species-specific isotope dilution analysis using the first biological reference material certified for multielemental speciation (oyster tissue, CRM 710, IRMM). The results obtained demonstrate that isotope dilution analysis is a powerful method allowing the simultaneous speciation of TBT and MMHg with high precision and excellent accuracy. Analytical problems related to low recovery during sample preparation are thus minimized by SIDMS. In addition, a rapid procedure allows us to establish a performant routine method using CGC-ICPMS technique.
Asunto(s)
Contaminantes Ambientales/análisis , Cromatografía de Gases y Espectrometría de Masas/métodos , Compuestos de Metilmercurio/análisis , Ostreidae/química , Compuestos de Trialquiltina/análisis , Animales , Contaminantes Ambientales/aislamiento & purificación , Isótopos de Mercurio , Compuestos de Metilmercurio/aislamiento & purificación , Compuestos de Metilmercurio/normas , Microondas , Estándares de Referencia , Radioisótopos de Estaño , Compuestos de Trialquiltina/aislamiento & purificación , Compuestos de Trialquiltina/normasRESUMEN
No disponible
Asunto(s)
Humanos , Cuidados Paliativos , Radioisótopos de Estroncio , Samario , Radioisótopos de Estaño , Costos de los Medicamentos , Resultado del Tratamiento , Radiofármacos , Dolor , Renio , Radioisótopos , Analgesia , Predicción , Neoplasias ÓseasRESUMEN
In previous studies, it was shown that waterborne Hg(II), Cd(II), and Mn(II) enter nerves innervating water-exposed sensory organs of fish and are transported to the brain by axonal transport. However, it is not known if organometals, such as tributyltin (TBT), can reach the brain of fish via the same route. In this work, we exposed rainbow trout (Oncorhynchus mykiss) to waterborne [113Sn]-TBT (4.2 kBq/L). Three fish were sampled after a 2-week exposure, and three others were sampled after a 2-week depuration period. Another group of four fish received an intravenous injection of [113Sn]-TBT and were sampled after 2 and 14 d. Distribution of the radiolabel was visualized and quantified by quantitative whole-body autoradiography. The brain accumulated a significant amount of 113Sn, with hot spots being found in parts receiving sensory nerves from water-exposed sensory organs, such as eminentia granulares (lateral lines organs). Labeling of the brain was also seen for i.v.-injected fish, indicating that the blood-brain barrier is not impervious to TBT or its metabolites. Nevertheless, the distribution of radioactivity in the brain was much more uniform, with no evident hot spot. Though the transfer [water --> gills --> blood stream --> blood-brain barrier --> brain] may account for a certain proportion of the radiolabel accumulation in fish brain, exposure to [113Sn]-TBT via water resulted in higher accumulation in some areas of the brain, of which the specific location strongly suggests that it was taken up in different water-exposed sensory nerve terminals and transported directly to the brain by axonal transport, as the parent compound or as a metabolite. The resulting local enhancement of the accumulation of butyltins might jeopardize the integrity of nervous system. Further work is needed to assess the toxicological significance of this process.
Asunto(s)
Transporte Axonal , Barrera Hematoencefálica , Química Encefálica , Exposición a Riesgos Ambientales , Oncorhynchus mykiss/fisiología , Compuestos de Trialquiltina/farmacocinética , Contaminantes Químicos del Agua/farmacocinética , Animales , Inyecciones Intravenosas , Medición de Riesgo , Radioisótopos de Estaño , Distribución TisularRESUMEN
UNLABELLED: (186)Re-1,1-hydroxyethylidene diphosphonate (etidronate) can be used for the palliative treatment of metastatic bone pain. A randomized, placebo-controlled study using (186)Re-etidronate was conducted on end-stage prostate cancer patients with metastatic bone pain. METHODS: Pain relief was assessed using an electronic diary containing questions reflecting the multidimensional character of chronic pain. The diary was marked twice daily for a maximum of 14 wk (2 wk before and 12 wk after the injection). Pain response was determined using a specific decision rule in which pain intensity, medication index, and daily activities were the core determinants. A positive response day was defined as a day on which pain intensity was reduced > or = 25% compared with baseline values, while medication index and daily activities were at least constant, or on which pain intensity was reduced < 25% and medication index or daily activities improved > or = 25%, without worsening of the remaining factor. The total response (%) was defined as the number of positive response days divided by the number of days of follow-up. RESULTS: Of the 111 included patients, 79 were evaluable (43 (186)Re-etidronate, 36 placebo). Thirty-two patients were excluded from the analysis because of incomplete datasets. The total response of the patients treated with (186)Re-etidronate varied from 0% to 96% (mean, 27%, or 23/84 d). In the placebo group, the total response varied from 0% to 80% (mean, 13%, or 11/84 d; Mann-Whitney U test, P < 0.05). The number of patients who requested radiotherapy was higher in the placebo group (67%) than in the (186)Re-etidronate group (44%) (relative risk, 1.51; Fisher's exact test, P = 0.069). CONCLUSION: This randomized controlled trial confirmed that, compared with placebo, (186)Re-etidronate resulted in a significantly longer pain response in the treatment of bone pain from metastasized prostate cancer.
Asunto(s)
Neoplasias Óseas/radioterapia , Neoplasias Óseas/secundario , Ácido Etidrónico/uso terapéutico , Compuestos Organometálicos/uso terapéutico , Cuidados Paliativos , Neoplasias de la Próstata/patología , Renio/uso terapéutico , Radioisótopos de Estaño/uso terapéutico , Anciano , Método Doble Ciego , Humanos , Masculino , Dimensión del Dolor , Radiofármacos/uso terapéuticoRESUMEN
The sorption of tin ions on human teeth from water and other drinks has been studied by the radioactive tracer technique using the isotope 113Sn (T(1/2) = 115.1 d) as a tracer. The tooth holds a minimum amount of tin from coffee and a maximum amount is held from water and from tea with sugar. The same technique was also used to study the desorption of tin already taken up on the teeth. It has been found that sorbed tin is hardly desorbed from the teeth specimens. The high uptake of tin on human teeth from various drinks showed that teeth act as a natural sieve holding trace elements.
Asunto(s)
Radioisótopos de Estaño/metabolismo , Diente/metabolismo , Contaminantes Radiactivos del Agua/metabolismo , Adsorción , Adulto , Humanos , Persona de Mediana EdadRESUMEN
BACKGROUND: It has been affirmed that observational studies give analogous results to randomised controlled ones. METHODS: A multicentre observational trial was conducted between 1996-1998 in order to evaluate the efficacy of palliative radionuclide therapy for bone metastases in a large number of patients. An evaluation was made on 510 patients with prostate cancer and painful bone metastases, treated with a single iv. dose of 89Sr-chloride (527 treatments) or 186Re-HEDP (83 treatments), in 29 Italian Nuclear Medicine Departments. Eighty-one patients received up to five injections, totalling 100 retreatments. Patients were followed up for a period of 3 months-2 years. Results were expressed at four levels of response: excellent, good, mild, and nil. RESULTS: Responses were excellent in 26.4%, good in 33.3%, mild in 21.3% and nil in 19% of all treatments, while good and excellent responses were obtained in 48% of retreatments. No statistically significant correlations were found between response and age of patients, skeletal extension of tumour, pretherapeutic PSA levels, evidence of non-bony metastases, previous chemotherapy and/or external-beam radiotherapy; osteolytic lesions responded worse than osteoblastic or mixed ones. Hematological toxicity (mild to moderate), mainly affecting platelets, was observed in 25.5% of all treatments and in 38.9% of retreatments. No clear differences were found between the two radiopharmaceuticals employed. CONCLUSIONS: Bearing in mind that observational studies can provide just as accurate results as randomised controlled trials, this study confirms the main findings of various limited monocentre trials.