RESUMEN
Introdução: Essa revisão sistemática foi conduzida para avaliar se a associação da aplicação da injeção de agregados plaquetários quando comparada a outras terapias faciais favorece no rejuvenescimento facial em pacientes adultos. Métodos: A pesquisa buscou ensaios clínicos randomizados que compararam uso de técnicas de rejuvenescimento facial isoladas com as mesmas técnicas aliadas à injeção de agregados plaquetários. A busca foi realizada em bases de dados indexadas e literatura cinzenta. A ferramenta de risco de viés da "Cochrane Collaboration" foi aplicada para a avaliação da qualidade dos estudos. Resultados: Foram identificados 7137 artigos. Apenas quatro estudos permaneceram na síntese qualitativa, e os demais foram considerados com risco indefinido de viés nos domínios chaves. Conclusão: Existem poucos estudos na literatura que comparam o uso de agregados plaquetários em rejuvenescimento facial e os que estão disponíveis têm risco de viés "indefinido" ou "alto". Há necessidade de realizar mais estudos clínicos bem delineados que comparem o uso de injeção de agregados plaquetários associados ou não às técnicas de rejuvenescimento facial.
Introduction: This systematic review was conducted to assess whether the use of a platelet aggregate injection with or without associated facial rejuvenation techniques favors facial rejuvenation in adult patients. Methods: Randomized clinical trials that compared the use of techniques for facial rejuvenation alone with the same techniques coupled with the injection of platelet aggregates were searched. The search was performed in indexed databases and in the gray literature. The Cochrane Collaboration bias risk tool was applied to assess the quality of the studies. Results: In total, 7137 articles were identified. Only four studies remained in the qualitative synthesis, and the others were considered as having undefined bias risk in the key domains. Conclusion: There are few studies in the literature that compare the use of platelet aggregates in facial rejuvenation and those that are available have a risk of "undefined" or "high" bias. There is a need for more well-designed clinical studies comparing the use of platelet aggregate injection with or without associated facial rejuvenation techniques.
Asunto(s)
Masculino , Femenino , Adulto , Rejuvenecimiento/fisiología , Rejuvenecimiento/psicología , Protocolos Clínicos/normas , Plasma Rico en Plaquetas/citología , Plasma Rico en Plaquetas/inmunología , Regeneración de la Piel con Plasma/efectos adversos , Regeneración de la Piel con Plasma/métodos , Fibrina Rica en Plaquetas/citologíaRESUMEN
Skin injuries are frequent in horses, and one of the treatments used for such injuries is the platelet-rich plasma (PRP). The objective of this experiment was to macroscopically and microscopically investigate the process of healing by second intention in skin wounds of eight healthy gelding crossbred horses treated (T) or untreated (UT) with a single dose of leukocyte-poor PRP (LP-PRP). Three squareshaped wounds were induced in both gluteal regions. After 12 h of wound induction, 0.5 mL LP-PRP was administered in each border of the lesion in one of gluteal region. Contralateral wounds were UT. Six skin biopsies were obtained with a 6-mm Punch. Macroscopic variables of one of the non-biopsied wounds were evaluated. Samples were processed for histomorphometric evaluation. No difference was observed between the time required for wound closure in the two groups. Histomorphometric analysis performed 14 days after wound induction revealed higher (p = 0.034) angiogenesis and number (p = 0.0179) of total leukocytes in T wounds. Fibrocytes numbers increased significantly (p = 0.023) on day 7 after injury in the UT group. General microscopic evaluation performed independently of scores and morphometric analysis revealed that the majority of the T wounds showed better healing variables in the sections analyzed after complete macroscopic closure of the wound. A single injected dose of LP-PRP 12 h after wound induction in horses does not interfere with the wound healing process but reveals that majority of the T wounds exhibit better healing histomorphometric characteristics.
Asunto(s)
Animales , Caballos/anatomía & histología , Caballos/lesiones , Cicatrización de Heridas/fisiología , Leucocitos , Péptidos y Proteínas de Señalización Intercelular , Regeneración de la Piel con Plasma/veterinariaRESUMEN
Skin injuries are frequent in horses, and one of the treatments used for such injuries is the platelet-rich plasma (PRP). The objective of this experiment was to macroscopically and microscopically investigate the process of healing by second intention in skin wounds of eight healthy gelding crossbred horses treated (T) or untreated (UT) with a single dose of leukocyte-poor PRP (LP-PRP). Three squareshaped wounds were induced in both gluteal regions. After 12 h of wound induction, 0.5 mL LP-PRP was administered in each border of the lesion in one of gluteal region. Contralateral wounds were UT. Six skin biopsies were obtained with a 6-mm Punch. Macroscopic variables of one of the non-biopsied wounds were evaluated. Samples were processed for histomorphometric evaluation. No difference was observed between the time required for wound closure in the two groups. Histomorphometric analysis performed 14 days after wound induction revealed higher (p = 0.034) angiogenesis and number (p = 0.0179) of total leukocytes in T wounds. Fibrocytes numbers increased significantly (p = 0.023) on day 7 after injury in the UT group. General microscopic evaluation performed independently of scores and morphometric analysis revealed that the majority of the T wounds showed better healing variables in the sections analyzed after complete macroscopic closure of the wound. A single injected dose of LP-PRP 12 h after wound induction in horses does not interfere with the wound healing process but reveals that majority of the T wounds exhibit better healing histomorphometric characteristics.(AU)
Asunto(s)
Animales , Caballos/lesiones , Caballos/anatomía & histología , Leucocitos , Cicatrización de Heridas/fisiología , Regeneración de la Piel con Plasma/veterinaria , Péptidos y Proteínas de Señalización IntercelularRESUMEN
Background: In recent decades, many researches have been conducted on processes involved in tissue repairing, mainly in the development of resources and technology designed to improve the wound healing progress. Platelet rich plasma (PRP) derived from autologous blood is defined as a plasma volume with platelet concentration higher than physiological level. It is an autogenous and low cost source of growth factors, which are essential for tissue regeneration due to their angiogenic, mitogenic, and chemotactic properties. The aim of this study was evaluate two forms of PRP- liquid and gel - regarding their capacity to influence quality and repair time of standardized skin injuries. Materials, Methods & Results: New Zealand healthy rabbits were distributed in three groups (n = 6): control group (CG), liquid platelet rich plasma group (LIQPRP), and gel platelet rich plasma group (GELPRP). Acute skin lesions were inducted in two areas approximately 2 cm close to scapular edge and depth including epidermis, dermis, and hypodermis to external muscular fascia. Animals received treatment according to each group. Injuries were measured with digital pachymeter in two directions: longer length (l) and longer width (w), every two days. Areas and healing rates were calculated. Microscopic analysis samples were collected on days seven and 14 and evaluated through hematoxylin and eosin [...]
Asunto(s)
Animales , Conejos , Cicatrización de Heridas/fisiología , Piel/lesiones , Plasma Rico en Plaquetas , Regeneración de la Piel con Plasma/veterinaria , Tratamiento Basado en Trasplante de Células y Tejidos/veterinariaRESUMEN
Background: In recent decades, many researches have been conducted on processes involved in tissue repairing, mainly in the development of resources and technology designed to improve the wound healing progress. Platelet rich plasma (PRP) derived from autologous blood is defined as a plasma volume with platelet concentration higher than physiological level. It is an autogenous and low cost source of growth factors, which are essential for tissue regeneration due to their angiogenic, mitogenic, and chemotactic properties. The aim of this study was evaluate two forms of PRP- liquid and gel - regarding their capacity to influence quality and repair time of standardized skin injuries. Materials, Methods & Results: New Zealand healthy rabbits were distributed in three groups (n = 6): control group (CG), liquid platelet rich plasma group (LIQPRP), and gel platelet rich plasma group (GELPRP). Acute skin lesions were inducted in two areas approximately 2 cm close to scapular edge and depth including epidermis, dermis, and hypodermis to external muscular fascia. Animals received treatment according to each group. Injuries were measured with digital pachymeter in two directions: longer length (l) and longer width (w), every two days. Areas and healing rates were calculated. Microscopic analysis samples were collected on days seven and 14 and evaluated through hematoxylin and eosin [...](AU)
Asunto(s)
Animales , Conejos , Cicatrización de Heridas/fisiología , Plasma Rico en Plaquetas , Regeneración de la Piel con Plasma/veterinaria , Piel/lesiones , Tratamiento Basado en Trasplante de Células y Tejidos/veterinariaRESUMEN
Se describe el caso clínico de una paciente de 50 años de edad, quien acudió a consulta con signos de envejecimiento facial, para solicitar un tratamiento restituido sin intervención quirúrgica, por lo cual se decidió aplicar la terapia regenerativa con plasma rico en plaquetas autólogas, teniendo en cuenta que es un tratamiento inocuo, y carente de complicaciones. Finalmente, el cambio fue evidente y la fémina quedó satisfecha con los resultados estéticos y faciales obtenidosAU)
The case report of a 50 years patient is described who presented signs of facial aging, to request a restoration treatment without surgical intervention, reason why it was decided to apply her the regenerative therapy with rich autologous platelets plasma, keeping in mind that it is an innocuous and lack of complications treatment. Finally, the change was evident and the patient was satisfied with the obtained aesthetic and facial results(AU)
Asunto(s)
Humanos , Femenino , Adulto , Medicina Regenerativa , Regeneración de la Piel con Plasma , Rejuvenecimiento , Plasma Rico en PlaquetasRESUMEN
Fundamento: la bioestimulación facial con plasma rico en plaquetas es un método actual de rejuvenecimiento facial que entra dentro de las terapias regenerativas. Objetivo: mostrar el papel principal de la bioestimulación como método positivo en las características de la piel facial. Métodos: se realizó una revisión bibliográfica de un total de 140 artículos originales publicados en Pubmed, Medline, Scielo y Google académico en los idiomas inglés y español mediante el gestor de referencias bibliográficas Endnote x9, de ellos se utilizaron 48 citas seleccionadas para realizar la revisión. Desarrollo: el envejecimiento es un proceso muy complejo, donde el envejecimiento cutáneo es una de sus manifestaciones más evidentes, por lo que el cirujano plástico busca constantemente formas de lograr atenuar este proceso, una de estas alternativas es la infiltración facial con plasma rico en plaquetas. Se describe la técnica de procesamiento de la sangre para obtener el plasma rico en plaquetas y el método empleado para la bioestimulación facial. Indicaciones y contraindicaciones del proceder. Conclusiones: la bioestimulación facial con plasma rico en plaquetas es un método sencillo, libre de complicaciones dado que se trabaja con material autólogo, mediante el cual se logran cambios positivos en la piel.
Background: facial biostimulation with platelet-rich plasma is a modern method for facial rejuvenation that is part of the regeneration therapies. Objective: to show the main role of biostimulation as a positive method for the characteristics of facial skin. Methods: a bibliographic review of 140 original articles published in Pubmed, Medline, Scielo and academic Google in English and Spanish, was made by means of the reference management software Endnote x9. Forty-eight citations were selected to make the review. Development: aging is a complex process and skin aging is one of its clearest manifestations; that’s why, plastic surgeons are constantly looking for new ways to reduce this process. One of these alternatives is facial infiltration with platelet-rich plasma. The technique of processing blood to obtain platelets-rich plasma and the method used for facial biostimulation are described. Indications and contraindications of the procedure are also described. Conclusions: facial biostimulation with platelet-rich plasma is a simple, complications-free method since the procedure is made with an autologous by means of which positive changes in the skin are achieved.
Asunto(s)
Humanos , Plasma Rico en Plaquetas , Regeneración de la Piel con PlasmaRESUMEN
La presente revisión fue realizada con el objetivo de ampliar los conocimientos sobre el envejecimiento cutáneo y los tratamientos restitutivos empleados en la cirugía plástica ocular, especialmente la bioestimulación cutánea con plasma rico en plaquetas, como alternativa novedosa de rejuvenecimiento periocular. Se realizó una búsqueda bibliográfica amplia y actualizada en bases de datos que ofrece Infomed, como Ebsco, Hinari, Pubmed, Google académico y textos básicos de Oftalmología y Cirugía Estética. El plasma rico en plaquetas es un preparado biológico efectivo para la bioestimulación cutánea; incrementa la producción de colágeno; elastina y ácido hialurónico, proporciona una piel con más brillo, mejor textura, hidratación y elasticidad; presenta múltiples ventajas y mínimas complicaciones, lo que contribuye a elevar la calidad de vida de los pacientes(AU)
The objective of this review was to expand knowledge on skin aging and restorative treatments used in ocular plastic surgery, especially cutaneous biostimulation with platelet-rich plasma, as a novel alternative of periocular rejuvenation. A comprehensive literature search was performed in updated databases that Infomed provides such as Ebsco, Hinari, Pubmed and Google and basic academic texts of cosmetic surgery and ophthalmology. The platelet-rich plasma is an effective biological preparation for skin biostimulation, increases the production of collagen, elastin and hyaluronic acid, and provides a brighter skin, improved texture, hydration and elasticity. It really has many advantages and minimal complications, thus contributing to raise the quality of life of patients(AU)
Asunto(s)
Humanos , Regeneración de la Piel con Plasma , Plasma Rico en Plaquetas , Bases de Datos Bibliográficas/estadística & datos numéricos , Calidad de VidaRESUMEN
Fundamento: la bioestimulación facial con plasma rico en plaquetas es un método actual de rejuvenecimiento facial que entra dentro de las terapias regenerativas.Objetivo: mostrar el papel principal de la bioestimulación como método positivo en las características de la piel facial.Métodos: se realizó una revisión bibliográfica de un total de 140 artículos originales publicados en Pubmed, Medline, Scielo y Google académico en los idiomas inglés y español mediante el gestor de referencias bibliográficas Endnote x9, de ellos se utilizaron 48 citas seleccionadas para realizar la revisión.Desarrollo: el envejecimiento es un proceso muy complejo, donde el envejecimiento cutáneo es una de sus manifestaciones más evidentes, por lo que el cirujano plástico busca constantemente formas de lograr atenuar este proceso, una de estas alternativas es la infiltración facial con plasma rico en plaquetas. Se describe la técnica de procesamiento de la sangre para obtener el plasma rico en plaquetas y el método empleado para la bioestimulación facial. Indicaciones y contraindicaciones del proceder. Conclusiones: la bioestimulación facial con plasma rico en plaquetas es un método sencillo, libre de complicaciones dado que se trabaja con material autólogo, mediante el cual se logran cambios positivos en la piel(AU)
Background: facial biostimulation with platelet-rich plasma is a modern method for facial rejuvenation that is part of the regeneration therapies.Objective: to show the main role of biostimulation as a positive method for the characteristics of facial skin.Methods: a bibliographic review of 140 original articles published in Pubmed, Medline, Scielo and academic Google in English and Spanish, was made by means of the reference management software Endnote x9. Forty-eight citations were selected to make the review.Development: aging is a complex process and skin aging is one of its clearest manifestations; thats why, plastic surgeons are constantly looking for new ways to reduce this process. One of these alternatives is facial infiltration with platelet-rich plasma. The technique of processing blood to obtain platelets-rich plasma and the method used for facial biostimulation are described. Indications and contraindications of the procedure are also described. Conclusions: facial biostimulation with platelet-rich plasma is a simple, complications-free method since the procedure is made with an autologous by means of which positive changes in the skin are achieved(AU)
Asunto(s)
Humanos , Plasma Rico en Plaquetas , Regeneración de la Piel con PlasmaRESUMEN
La presente revisión fue realizada con el objetivo de ampliar los conocimientos sobre el envejecimiento cutáneo y los tratamientos restitutivos empleados en la cirugía plástica ocular, especialmente la bioestimulación cutánea con plasma rico en plaquetas, como alternativa novedosa de rejuvenecimiento periocular. Se realizó una búsqueda bibliográfica amplia y actualizada en bases de datos que ofrece Infomed, como Ebsco, Hinari, Pubmed, Google académico y textos básicos de Oftalmología y Cirugía Estética. El plasma rico en plaquetas es un preparado biológico efectivo para la bioestimulación cutánea; incrementa la producción de colágeno; elastina y ácido hialurónico, proporciona una piel con más brillo, mejor textura, hidratación y elasticidad; presenta múltiples ventajas y mínimas complicaciones, lo que contribuye a elevar la calidad de vida de los pacientes(AU)
The objective of this review was to expand knowledge on skin aging and restorative treatments used in ocular plastic surgery, especially cutaneous biostimulation with platelet-rich plasma, as a novel alternative of periocular rejuvenation. A comprehensive literature search was performed in updated databases that Infomed provides such as Ebsco, Hinari, Pubmed and Google and basic academic texts of cosmetic surgery and ophthalmology. The platelet-rich plasma is an effective biological preparation for skin biostimulation, increases the production of collagen, elastin and hyaluronic acid, and provides a brighter skin, improved texture, hydration and elasticity. It really has many advantages and minimal complications, thus contributing to raise the quality of life of patients(AU)
Asunto(s)
Humanos , Bases de Datos Bibliográficas/estadística & datos numéricos , Plasma Rico en Plaquetas , Regeneración de la Piel con Plasma , Calidad de VidaRESUMEN
OBJECTIVE: Assess the occurrence of secondary brow ptosis after upper lid blepharoplasty. METHODS: Forty-five individuals (n = 90 brows) submitted to upper lid blepharoplasty, were assessed by means of a comparative analysis using pre- and post-operatively digital photographs, in the primary position of the eye. The images were processed using ImageJ "software", transferred to a computer, to an electronic Microsoft Excel 2002(®) worksheet. Angular measurements were used, taking the lateral canthal angle of the brow, the most medial point of the brow, the medial canthal angle and the lateral canthal angle of the lid as anatomical reference points. When the outer angles were reduced or the inner angles increased after surgery this was considered a brow ptosis. Individuals who had undergone lid surgery associated with the eyebrow, previous eyebrow surgery and those with eyelid ptosis were excluded. The difference between the pre-operative and post-operative measurements were analyzed statistically using the Student's t-test for paired samples and the angular variation was compared with their corresponding contralateral sample using Wilcoxon's non-parametric test. RESULTS: The measurements obtained after the blepharoplasty show significant variations from those before the surgery, indicating that the correction of redundant tissues in the brow accentuates the tendency of the eyebrow to move down. The alterations are more important in the lateral portion of the eyebrow and they occur bilaterally. CONCLUSION: The assessment of angular measurements obtained pre- and post-operatively showed that there are secondary changes in the position of the eyebrow as a result of upper eyelid blepharoplasty.