[Anxiety level and addiction to first-time prescriptions of anxiolytics: a psychometric study]. / Niveau d'anxiété et de dépendance des primoconsommants d'anxiolytiques: une étude de psychométrie.

CONTEXT: The anxiety epidemic and its corollary, the widespread prescription of anxiolytics, present a public health problem in view of the risk of addiction to these drugs. OBJECTIVE: To assess the level of anxiety and addiction in the borderline population at risk of addiction. DESIGN: The study analyzed a series of patients in the third month of their first prescription for anxiolytics. It used two validated scales: the Hospital Anxiety and Depression scale (HAD), and a French scale measuring addiction (the "Echelle Cognitive d'Attachement aux Benzodiazepines" or ECAB). RESULT: 83% of patients were still anxious at the third month of treatment. 23% had become addicted. DISCUSSION: There is a contradiction between the prolonged prescription and use of anxiolytics, which are associated with a risk of addiction, and professional guidelines that recommend short treatment for outpatients using these drugs for the first time.

[The inhibitor of free radical processes decrease of protein biosynthesis in gun short wound tissues and weaken development of the general adaptation syndrome].

The dynamics of total protein biosynthesis and procollagen biosynthesis in skeletal muscle of injury tissues with the antioxidant BHT (dibunol) treatment and with common healing were studied. The obtained date indicate that the AO treatment reduce the rate of biosynthesis both the total proteins and procollagen at the 3th day of healing. Dibunol also considerably reduce the protein biosynthesis in adrenals and brake of corticosteroids biogenesis as measured by ESR-signals intensity of reduced adrenodoxine. AO treatment also reduce the protein biosynthesis in thymus, spleen and bone marrow. The lowering of functional activity of endocrine and immune systems indicate that the AO significantly inhibit the systemic reactions of organism induced by acute wound affect. It was suggested that as "primary mediator" of stress-reaction may be considered lipoperoxide radicals and decay products of lipohydroperoide.

[Neuropeptides in atopic dermatitis in children]. / Neiropeptidy pri atopicheskom dermatite u detei.

Radioimmunoassay was used to measure the blood plasma content of endogenous opioid peptides (beta-andorphine, methionin- and leucine-enkephalins), R substance, calcium-regulating hormones (parathyroid hormone and carcitonin), ionized calcium and cortisol in 152 children aged 6 months to 12 years with atopic dermatitis. The data obtained were compared to those obtained in healthy children. The stress-activating and stress-limiting systems were established to be activated in all the patients. It is concluded that the intensity of the adaptation compensatory process depends on the clinical form, disease standing, and spreading of skin impairment.

[The characteristics of a differential approach to therapy in the stress syndrome taking into account the stages of the process]. / Osobennosti differentsirovannogo podkhoda k terapii stress-sindroma s uchetom stadiinosti protsessa.

Hereby is stated the data of the necessity of the differential approach to the therapy of stress-syndrome taking into consideration the stages of the process. Pharmacological corrections of the oscillations of the antioxidation system of protection during stress is carried out in the stage of quick adaptation and its conversion into long acting, i.e. into the period, when oscillations of biochemical indexes of the antiradical system of protection are compensated. In this an important role is played by using psychotropic substances, which have a quality of the antiradical protection.