RESUMEN
This review on herpes simplex virus type I and type II (HSVI, HSVII) summarizes recent developments in clinical manifestations and treatment interventions for primary and recurrent orolabial and genital herpes, as well as those regarding vaccination issues. Among the clinical presentations, the relationship between pyogenic granuloma and chronic HSVI infection; HSV-related folliculitis; verrucous HSVI and HSVII lesions; the role of recurrent HSVI infection in burning mouth syndrome; HSVI and HSVII infection of the periareolar area; zosteriform HSV; the "knife-cut sign"; and the preferential colonization and infection of preexisting dermatoses by HSVI or HSVII are discussed. The usual antiviral treatment regimens for primary and recurrent orolabial and genital herpes are compared to short-term and one-day treatment options. New anti-HSVI and anti-HSVII agents include amenavir, pritelivir, brincidofovir, valomaciclovir, and FV-100. Therapeutic or preventive vaccination against HSVI and HSVII infections still remains a highly desirable treatment aim, which, unfortunately, has no clinically relevant applications to date.
Asunto(s)
Herpes Simple/virología , Herpesvirus Humano 1/patogenicidad , Herpesvirus Humano 2/patogenicidad , Aciclovir/uso terapéutico , Antivirales/uso terapéutico , Síndrome de Boca Ardiente/diagnóstico , Síndrome de Boca Ardiente/tratamiento farmacológico , Síndrome de Boca Ardiente/virología , Herpes Genital/diagnóstico , Herpes Genital/tratamiento farmacológico , Herpes Genital/virología , Herpes Labial/diagnóstico , Herpes Labial/tratamiento farmacológico , Herpes Labial/virología , Herpes Simple/diagnóstico , Herpes Simple/tratamiento farmacológico , Humanos , Ensayos Clínicos Controlados Aleatorios como Asunto , Recurrencia , Estomatitis Herpética/diagnóstico , Estomatitis Herpética/tratamiento farmacológico , Estomatitis Herpética/virología , Vacunación , Virulencia , Zoster Sine Herpete/diagnóstico , Zoster Sine Herpete/tratamiento farmacológico , Zoster Sine Herpete/virologíaRESUMEN
We present two cases of burning mouth syndrome (BMS)-of 8-month duration in a 61-year-old woman and of 2-year duration in a 63-year-old woman-both associated with increased levels of antivaricella zoster virus (VZV) IgM antibodies in serum and with pain that improved with antiviral treatment. Combined with our previous finding of BMS due to herpes simplex virus type 1 (HSV-1) infection, we recommend evaluation of patients with BMS not only for VZV or HSV-1 DNA in the saliva, but also for serum anti-VZV and anti-HSV-1 IgM antibodies. Both infections are treatable with oral antiviral agents.
Asunto(s)
Síndrome de Boca Ardiente/complicaciones , Herpes Zóster/complicaciones , Anticuerpos Antivirales , Antivirales/uso terapéutico , Síndrome de Boca Ardiente/tratamiento farmacológico , Síndrome de Boca Ardiente/virología , Femenino , Herpes Zóster/tratamiento farmacológico , Humanos , Persona de Mediana Edad , Saliva/virologíaRESUMEN
Burning mouth syndrome is characterised by chronic orofacial burning pain. No dental or medical cause has been found. We present a case of burning mouth syndrome of 6 months duration in a healthy 65-year-old woman, which was associated with high copy numbers of herpes simplex virus type 1 (HSV-1) DNA in the saliva. Her pain resolved completely after antiviral treatment with a corresponding absence of salivary HSV-1 DNA 4 weeks and 6 months later.