Terceiro molar superior impactado invertido: relato de caso / Invert impacted superior third molar: case report

Introdução: A impactação invertida dos dentes é raro, correspondendo a menos de 1% dos casos de terceiros molares impactados na maxila. O elemento dentário afetado pode permanecer por longos períodos sem apresentar sintomatologia, entretanto, podem provocar problemas dentários e desenvolvimento de patologias dos maxilares. O tratamento cirúrgico é proposto em casos em que o folículo dentário se apresentar patologicamente afetado, ou necessidade estética, funcional e/ou comportamental. Relato de caso: Paciente do sexo feminino, leucoderma, 35 anos, ASA I, procurou atendimento na Clínica Escola de Odontologia da Universidade Estadual da Paraíba, UEPB, Campus VIII em Araruna/ PB, queixando-se da presença de quadros de sintomatologia dolorosa na região direita da maxila. Por meio da avaliação clínico-radiográfica concluiu-se que a impactação invertida do elemento 18 era responsável por originar os episódios de dor. Devido a isto e com a finalidade de prevenir o desencadeamento de complicações futuras, optou-se, pela remoção cirúrgica do dente. Considerações finais: A exodontia de dentes invertidos - quando indicada - se configura como uma técnica cirúrgica eficiente. Assim, uma vez optada pela intervenção cirúrgica, o profissional deve realizar um planejamento minucioso da técnica operatória... (AU)

Introduction: Inverted impaction of teeth is rare, corresponding to less than 1% of cases of third molars impacted on the maxilla. The affected dental element can remain for long periods without presenting symptoms, however, they can cause dental problems and the development of pathologies of the jaws. Surgical treatment is proposed in cases where the dental follicle is pathologically affected, or has an aesthetic, functional and/or behavioral need. Case report: Female patient, leucoderma, 35 years old, ASA I, sought care at the Dental School Clinic of the State University of Paraíba, UEPB, Campus VIII in Araruna/PB, complaining of the presence of painful symptoms in the right region of the maxilla. Through clinical-radiographic evaluation, it was concluded that the inverted impaction of element 18 was responsible for causing episodes of pain. Because of this and in order to prevent the triggering of future complications, we opted for surgical removal of the tooth. Final considerations: The extraction of inverted teeth - when indicated - is an efficient surgical technique. Thus, once opted for surgical intervention, the professional must carry out a thorough planning of the operative technique... (AU)

A three-dimensional analysis of primary failure of eruption in humans and mice.

OBJECTIVES: Primary failure of eruption (PFE) is a genetic disorder exhibiting the cessation of tooth eruption. Loss-of-function mutations in parathyroid hormone (PTH)/parathyroid hormone-related peptide (PTHrP) receptor (PTH/PTHrP receptor, PPR) were reported as the underlying cause of this disorder in humans. We showed in a PFE mouse model that PTHrP-PPR signaling is responsible for normal dental follicle cell differentiation and tooth eruption. However, the mechanism underlying the eruption defect in PFE remains undefined. In this descriptive study, we aim to chronologically observe tooth eruption and root formation of mouse PFE molars through 3D microCT analyses. SETTING AND SAMPLE POPULATION: Two individuals with PFE were recruited at Showa University. A mouse PFE model was generated by deleting PPR specifically in PTHrP-expressing dental follicle and divided into three groups, PPRfl/fl ;R26RtdTomato/+ (Control), PTHrP-creER;PPRfl/+ ;R26RtdTomato/+ (cHet), and PTHrP-creER;PRRfl/fl ;R26RtdTomato/+ (cKO). MATERIALS AND METHODS: Images from human PFE subjects were acquired by CBCT. All groups of mouse samples were studied at postnatal days 14, 25, 91, and 182 after a tamoxifen pulse at P3, and superimposition of 3D microCT images among three groups was rendered. RESULTS: Mouse and human PFE molars exhibited a similar presentation in the 3D CT analyses. The quantitative analysis in mice demonstrated a statistically significant decrease in the eruption height of cKO first and second molars compared to other groups after postnatal day 25. Additionally, cKO molars demonstrated significantly shortened roots with dilacerations associated with the reduced interradicular bone height. CONCLUSIONS: Mouse PFE molars erupt at a much slower rate compared to normal molars, associated with shortened and dilacerated roots and defective interradicular bones.

Enlarged follicles and temporomandibular joint abnormalities in mucolipidosis Type III.

Mucolipidosis Type III, or pseudo-Hurler polydystrophy, is a rare genetic abnormality, the result of a mutation to one of two genes that encode the hexameric protein N-acetylglucosaminyl-1-phosphotransferase (Glc-NAc-PT). The abnormality results in the accumulation of unprocessed macromolecules in cell and tissue compartments throughout the body. In this case report, we describe the clinical and radiographic findings of a 15-year-old male with this disorder. He presented with bilateral ectopically developing mandibular molar teeth with enlarged follicles and multiple joint involvement, including the temporomandibular joints. The patient underwent surgical removal of the molar teeth and curettage of the associated follicles. The subsequent histopathological examination of the tissues revealed hyperplastic follicles suggestive of dentigerous cysts. This report presents the plain film and cone beam CT examinations of the patient.

A role for TNF in bone resorption of deciduous molars in human beings.

In this study, tumor necrosis-alpha was sampled from the gingival crevice of human deciduous molars; this was compared with values measured from the crevice of those deciduous molars missing a permanent successor, and from the crevice of deciduous ankylosed molars. Tumor necrosis-alpha was harvested from the gingival crevice with magnetic microspheres coated with tumor necrosis-alpha antibodies. The amount of bead-bound tumor necrosis-alpha was quantified with the use of an enzyme-linked immunosorbent assay. One hundred seven sites (from 41 patients) were sampled; for each patient, the normal value was compared with either the molars missing a permanent successor or ankylosed value. The tumor necrosis-alpha levels were 1.6 times higher from the crevice of ankylosed deciduous molars when compared with normal deciduous molars and 2.6 times higher from the crevice of sites with a molar missing a permanent successor. The mean and standard error mean distribution of tumor necrosis-alpha expressed as picograms was: normal molars 91 pg (standard error mean +/- 20), ankylosed molars 150 pg (standard error mean +/- 31), and missing permanent successor 236 pg (standard error mean +/- 67). Analysis of variance showed the difference among the 3 means was close to attaining significant difference (F [2.104] = 2.7905, P =.066). Multiple comparison procedures indicated that the mean for molars missing a permanent successor and the normal groups were significantly different, P =.05. The results of this study suggest tumor necrosis-alpha values are elevated in the gingival crevice of deciduous molars with ankylosis and where the permanent tooth bud is congenitally missing.

Primary failure of tooth eruption: a unique case.

Primary failure of tooth eruption rarely occurs. This case represents a rare clinical situation and appears to reflect a generalized disturbance in the eruptive process, inasmuch as (1) deciduous and permanent dentition are affected, (2) incisors, molars, and premolars are involved in all quadrants, (3) skeletal and craniofacial growth are within normal limits, and (4) no systemic/genetic anomalies were detected. This is the first such case reported in the literature; diagnosis and management are discussed.

Mucopolysaccharidosis: MPS VI and associated delayed tooth eruption.

Eight cases of mucopolysaccharidosis Type VI (Maroteaux-Lamy syndrome) are reviewed and two cases are presented in detail. Developmental dental anomalies including unerupted and impacted permanent teeth and associated hyperplastic tooth follicles are seen frequently in MPS patients. The surgical implications and management are discussed. All patients reviewed had significant cardiovalvular disease. It is essential for the primary medical provider to establish early basic dental care and evaluation for delayed eruption of primary and permanent dentition. This will probably minimize the possibility of infective endocarditis and allow for early treatment of impacted teeth.

Rough hypoplastic amelogenesis imperfecta with follicular hyperplasia.

This report documents a unique case of rough hypoplastic amelogenesis imperfecta with apparent anterior oligodontia and multiple anomalies of the associated mesenchymally derived tissues. Multiple unerupted teeth showed hypercementosis, distorted roots with aberrant dentin formation, and marked follicular hyperplasia. The hyperplastic follicles had a complex histopathologic appearance that recapitulated some features of the WHO-type odontogenic fibroma. The features of these teeth, the nature of the associated follicular lesions, and their relationship to the unerupted teeth are discussed.

Contiguous enlarged dental follicles with histologic features resembling the WHO type of odontogenic fibroma.

Defective odontogenesis and/or retarded eruption of teeth can be associated with histologic features akin to odontogenic fibroma in the dental follicles. Unerupted mandibular premolar and molar teeth of a 24-year-old man were surgically exposed, yet the teeth failed to erupt. About a year and a half later, radiographs indicated further enlargement of the follicle of the premolar, and both teeth were subsequently surgically removed. Histologically, the follicles were composed of mature collagenous tissue among which epithelial islands and numerous clusters of calcified bodies were present. Indirect immunofluorescence showed positive staining for type I and type III collagen, which exhibited a sparse distribution, but not for the aminoterminal propeptide of type III procollagen. The hamartomatous nature of the lesions is discussed with emphasis on their histologic resemblance to the WHO type of odontogenic fibroma.

Alveolar bone graft resorption associated with abnormal dental follicle.

An unusual case of an alveolar bone graft that underwent almost complete resorption in association with a large radiolucent lesion around the erupting canine is reported. Clinical and radiographic follow-up after grafting is important to detect and manage any pathologic changes which might occur. Early detection of any abnormal radiologic changes and surgical intervention to excise the lesion could prevent further destruction of the grafted bone.