Assessment of a continuous passive motion assistive device in dogs following stifle surgery.

Canine rehabilitation optimizes recovery and the quality of life in dogs with musculoskeletal conditions or after surgery. Achieving proper range of motion (ROM) is vital post-stifle surgery, often accomplished through manual therapy and active exercises. We investigated the mechanical performance of a continuous passive motion (CPM) device for dogs and its potential use in canine rehabilitation therapy. In the ethical review process, our research was accepted to be evaluated in a sample of four dogs that had undergone left stifle surgery. Each dog underwent four sessions with the device at three different speeds. Results showed the device replicated extension angles close to goniometer measurements used in manual therapy. Flexion was also achieved, but not to the same extent. A force threshold stopped the device, avoiding discomfort in dogs with restricted ROM. Dog-specific factors like body position, opposition to movement, limb size, stage of recovery, haircoat, and discomfort, appeared to influence device operation. Mechanical improvements to allow for enhanced flexion are recommended in future CPM device designs, including a resistance threshold that could be adjusted for individual dogs and stages of healing. This study serves as a foundation for future advancements in canine rehabilitation systems. A canine CPM device may provide an affordable option to improve ROM. This could be beneficial for dog owners, who may not be comfortable with manual therapy, to assist with home rehabilitation exercises.

Early functional improvements using continuous passive motion therapy after angular-stable plate osteosynthesis of proximal humerus fractures - results of a prospective, randomized trial.

BACKGROUND: The use of continuous passive motion therapy (CPM) has led to promising results in the early phase of rehabilitation after surgical treatment of rotator cuff tears and arthrolysis of the elbow. However, its use has not been proven in other pathologies of the upper extremity. Therefore, the aim of the underlying study was to evaluate the use of CPM therapy after plate osteosynthesis of proximal humeral fractures. METHODS: 95 patients with isolated proximal humerus fractures were enrolled in a prospective, randomized study. Patients were assigned to a treatment group with (n = 48, CPM) or without CPM therapy (n = 47, CG). Four patients (2 of each cohort) violated the study protocol and were excluded. CPM therapy was used for 6 weeks after surgery 2-3 times daily. Functional (range of motion) and patient reported outcomes (PROM, Constant Score [CSS], QuickDASH, subjective shoulder value [SSV], pain on visual analogue scale [VAS]) were evaluated at 6 weeks, 3 and 12months. 60 patients completed the 1-year follow-up. RESULTS: The average patient age was 65.3 years (min: 27, max: 88, SD: ± 14.7). Seventy-two patients were female (79%). There was no difference regarding injury severity (2/3/4 part-fracture: 6/32/7 vs. 9/26/11, p = 0.867) and sex (p = 0.08). However, patients in the CPM group were significantly younger (CPM: 67 [min: 34, max: 82], CG: 74 [min: 27, max: 88], p = 0.032). After 6 weeks we observed a better range of motion for forward flexion (CPM: 90° [min: 50°, max: 180°] vs. CG: 80° [min: 20°, max: 170°] p = 0.035) and abduction (CPM: 80° [min: 40°, max: 180°] vs. CG: 70° [min: 20°, max: 180°], p = 0.048) in the CPM group. There was no difference regarding the further planes of motion or the assessed PROMs at 6 weeks. At 3 and 12 months the results between the treatment groups equalized with no further significant differences. CONCLUSION: The treatment with CPM increases the range of motion after plate osteosynthesis of proximal humerus fractures in the first 6 weeks after surgery. This effect is not sustained after 3 and 12months. The evaluated PROMs are not being influenced by CPM therapy. Hence the results of this prospective randomized study suggest that CPM can be a beneficial asset in the early period of rehabilitation after proximal humerus plate osteosynthesis. TRIAL REGISTRATION: The study protocol was registered in the US National Institutes of Health's database ( http://www. CLINICALTRIALS: gov ) registry under NCT05952622.

Acute effect of passive cycle-ergometry and functional electrical stimulation on nitrosative stress and inflammatory cytokines in mechanically ventilated critically ill patients: a randomized controlled trial

Early mobilization is beneficial for critically ill patients because it reduces muscle weakness acquired in intensive care units. The objective of this study was to assess the effect of functional electrical stimulation (FES) and passive cycle ergometry (PCE) on the nitrous stress and inflammatory cytometry in critically ill patients. This was a controlled, randomized, open clinical trial carried out in a 16-bed intensive care unit. The patients were randomized into four groups: Control group (n=10), did not undergo any therapeutic intervention during the study; PCE group (n=9), lower-limb PCE for 30 cycles/min for 20 min; FES group (n=9), electrical stimulation of quadriceps muscle for 20 min; and FES with PCE group (n=7), patients underwent PCE and FES, with their order determined randomly. The serum levels of nitric oxide, tumor necrosis factor alpha, interferon gamma, and interleukins 6 and 10 were analyzed before and after the intervention. There were no differences in clinical or demographic characteristics between the groups. The results revealed reduced nitric oxide concentrations one hour after using PCE (P<0.001) and FES (P<0.05), thereby indicating that these therapies may reduce cellular nitrosative stress when applied separately. Tumor necrosis factor alpha levels were reduced after the PCE intervention (P=0.049). PCE and FES reduced nitric oxide levels, demonstrating beneficial effects on the reduction of nitrosative stress. PCE was the only treatment that reduced the tumor necrosis factor alpha concentration.

Oxidative stress and immune system analysis after cycle ergometer use in critical patients

OBJECTIVE: The passive cycle ergometer aims to prevent hypotrophy and improve muscle strength, with a consequent reduction in hospitalization time in the intensive care unit and functional improvement. However, its effects on oxidative stress and immune system parameters remain unknown. The aim of this study is to analyze the effects of a passive cycle ergometer on the immune system and oxidative stress in critical patients. METHODS: This paper describes a randomized controlled trial in a sample of 19 patients of both genders who were on mechanical ventilation and hospitalized in the intensive care unit of the Hospital Agamenom Magalhães. The patients were divided into two groups: one group underwent cycle ergometer passive exercise for 30 cycles/min on the lower limbs for 20 minutes; the other group did not undergo any therapeutic intervention during the study and served as the control group. A total of 20 ml of blood was analysed, in which nitric oxide levels and some specific inflammatory cytokines (tumour necrosis factor alpha (TNF-α), interferon gamma (IFN-γ) and interleukins 6 (IL-6) and 10 (IL-10)) were evaluated before and after the study protocol. RESULTS: Regarding the demographic and clinical variables, the groups were homogeneous in the early phases of the study. The nitric oxide analysis revealed a reduction in nitric oxide variation in stimulated cells (p=0.0021) and those stimulated (p=0.0076) after passive cycle ergometer use compared to the control group. No differences in the evaluated inflammatory cytokines were observed between the two groups. CONCLUSION: We can conclude that the passive cycle ergometer promoted reduced levels of nitric oxide, showing beneficial effects on oxidative stress reduction. As assessed by inflammatory cytokines, the treatment was not associated with changes in the immune system. However, further research in a larger population is necessary for more conclusive results.

Recuperación de la artroplastia de rodilla a través de la movilización pasiva continua / Recovery from total knee arthroplasty through continuous passive motion

El propósito de este estudio es conocer los efectos de la movilización pasiva continua en pacientes intervenidos de artroplastia total de rodilla. Se desarrolló una estrategia de búsqueda en las bases de datos CSIC, PubMed, Cochrane Library Plus, Dialnet y PEDro con el fin de captar todos aquellos ensayos clínicos, en inglés y español, indexados de enero del 2000 a noviembre del 2014. Se identificaron 537 publicaciones, pero se incluyeron 12 estudios en esta revisión. La valoración de 1.153 pacientes demuestra que no existe una diferencia significativa en la mejora de la amplitud articular, dolor, equilibrio, marcha, cicatrización y estancia hospitalaria utilizando la movilización pasiva continua frente al tratamiento de fisioterapia habitual para la artroplastia total de rodilla. La aplicación de la movilización pasiva continua, a largo plazo, no aporta ningún beneficio en cuanto a la amplitud del rango articular, dolor y mejora de bipedestación y marcha en comparación con el tratamiento convencional de fisioterapia postoperatorio en la artroplastia total de rodilla. A corto plazo se consigue una mejora del rango de movilidad articular a la flexión de la rodilla (AU)

The purpose of this study was to know the effects of continuous passive mobilization in patients who underwent total knee arthroplasty. A search strategy was developed to retrieve all clinical trials, written in English and/or Spanish, published in the electronic search databases PubMed, Cochrane Library Plus, Dialnet, CSIC and PEDro. The inclusion criteria were: clinical trials published from January 2000 until November 2014 in English or Spanish. Out of 537 clinical trials that were potentially relevant, a total of 12 were included in this review. The evaluation of 1,153 patients shows that there is no significant difference in improving the range of the joint, pain, balance, motion, healing and hospital stay using continuous passive mobilization against the regular physiotherapy treatment for total knee arthroplasty. The application of continuous passive mobilization in the long-term does not provide any benefit in terms of the breadth of the range of the joint, pain and improvement of standing and motion in comparison with conventional postoperative physiotherapy treatment in total knee arthroplasty. In the short term an improvement is obtained in the range of joint motion in knee flexion (AU)

Eficacia de la terapia de movimiento inducido por restricción en niños con parálisis cerebral / Efficacy of constraint-induced movement therapy in children with cerebral palsy

Objetivo. Describir y analizar la eficacia de la terapia del movimiento inducido por restricción (TMIR) como parte del tratamiento integral de los niños con parálisis cerebral (PC). Estrategia de búsqueda. Se revisaron las bases de datos Medline, Physiotherapy Evidence Database, Ovid, Tripdatabase y Biblioteca Cochrane hasta marzo de 2008. Los resultados se completaron con el buscador Curbside.MD. Selección de estudio y datos. Se localizaron una serie de casos, tres estudios de cohortes, un Critical Appraisal Topics (CAT), tres ensayos clínicos aleatorizados (ECA), una revisión de ensayos clínicos aleatorizados y una revisión Cochrane. Síntesis de resultados. Se analizaron los resultados en base a: población de estudio, método de restricción, entrenamiento dirigido (TMIR, TMIR modificada o terapia de uso forzado), medidas de resultados, ámbito de aplicación y prestación de la intervención. Conclusiones. El objetivo de la TMIR no es restaurar la normalidad de la función motora en la extremidad superior afectada sino aumentar la funcionalidad de la misma. La función motora final obtenida tras la aplicación de TMIR depende, en parte, de la severidad inicial del trastorno. El resultado y el mantenimiento en el tiempo de las habilidades adquiridas varía de unos niños a otros, por lo que se ha demostrado como fundamental la colaboración de la familia durante y tras el tratamiento, estimulando la utilización de la extremidad afectada en las actividades de la vida diaria y realizando ejercicios de destreza manual

Objectives. To describe and analyze effectiveness of constraint-induced movement therapy as an intervention to children with cerebral palsy. Search strategy. We reviewed the following databases: Medline, Physiotherapy Evidence Database, Ovid, Tripdatabase y Biblioteca Cochrane up to march 2008. The results were completed with the Curbside.MD finder. Articles selection. We found one case series, three studies of cohorts, one CAT, three randomized clinical trials, a review of clinical trials and a Cochrane Collaboration review. Results. The results were analyzed on the basis of: studied population, method of restraint, guided training (CIMT, modified CIMT or forced use therapy), results measurement, application field, implementation of the intervention. Conclusions. The objective of the TMIR is not to recover the normality of the motor function in the superior extremity affected but to increase the functionality of the same one. The obtained final motor function after the application of TMIR depends partly on the initial severity of the disorder. The result and the maintenance in the time of the acquired abilities vary from children to others, reason why it has been demonstrated like fundamental the collaboration of the family during and after the treatment, stimulating the use of the extremity affected in the activities of the daily life and making exercises of manual skill