[Quantitative changes of the cytotrophoblast in underweight and normalweight newborn after risk pregnancy and antepartal therapy (author's transl)]. / Quantitative Veränderungen des Zottentrophoblasten bei unter- und normgewichtigen Neugeborenen nach Risikoschwangerschaft und antepartaler Therapie.

A histochemical-morphometric method was used to determine at the cytotrophoblast of 73 placentas, changes in the composition of the syncytium and in the Langhans' cell count in underweight and normalweight newborn with or without antepartal maternal therapy in comparison to newborn after uneventful pregnancy. The reduction of the percentage share of mature syncytium when the share of predegenerative and degenerative syncytium is increased, as weil as the increase in the average Langhans' cell count in the placentas of premature infants, hypotrophic and eutrophic infants delivered at term after risk pregnancy, compared with normal controls, is statistically significant. Significant differences in the percentage share of mature syncytium between the placentas of premature infants and hypotrophic infants delivered at term, as well as between placentas of eutrophic infants delivered at term, depending of the nature and severity of the risk, are discussed in connection with the significance of the syncytium for the processes of material transport. No correlation with the Apgar score and the occurrence of the respiratory distress syndrome of newborn, nor with the duration of the first and second stage of lavor with macroscopic placenta peculiarities, have been found. The good correlation between placenta findings and classification characteristics of newborn, and clinical aspects of the course of pregnancy, allows the possibility of diagnostic evaluation. Our results indicat also that the morphological performance must be included in the considerations explaining the success of treatment of placental insufficiency.

[Effect of various hormonal preparations on trophoblast growth in tissue culture]. / Vplyv deiakykh hormonal'nykh preparativ na rist trofoblastu v kul'turi tkanyny

PIP: The application of different methods of tissue culture, in particular, investigations on trophoblast cells outside the mother's body, opens new possibilities for understanding pathogenesis of premature interruption of pregnancy caused by the hormonal and metabolic disorders. To study the effects of various hormones (Choriogonien, estrone and estradiol) on the growth and development of trophoblast cells the method of tissue culture was applied. 683 histological preparations, obtained after incubating trophoblast tissues with and without hormones were examined. It was established that choriogonine in doses of 5-100 IU/L stimulated growth in trophoblast cells but 200-400 IU/L of hormone did not increase this stimulating effect. Estrone and estradiol added to incubated tissues in doses of 60-120 IU/L brought about no changes or else had a weak effect on development of cultivated tissues. When choriogonine (or estrone) was added to the trophoblast tissues together with blood serum taken from women in danger of premature interruption of pregnancy the negative effect of the serum on the development of the trophoblast cells was prevented.^ieng