Derrame pleural masivo como forma de presentación de un tumor de Krukenberg. Linfangitis carcinomatosa secundaria / Massive pleural effusion as a form of presentation of a Krukenberg tumor. Secondary carcinomatous lymphangitis

Presentamos el caso clínico de una paciente joven que acudió a Urgencias por disnea, objetivándose en la radiografía de tórax un derrame pleural derecho masivo y en la ecografía transvaginal, efectuada tras el hallazgo de un test de embarazo positivo, una masa ovárica. En la TC toraco-abdominal se observó, además, un engrosamiento de la mucosa gástrica, que fue valorado mediante gastroscopia, siendo la biopsia positiva para adenocarcinoma de células en anillo de sello. Ante estos hallazgos se confirmó el diagnóstico de tumor de Krukenberg, entidad poco frecuente con una forma de presentación también excepcional en forma de falso síndrome de Meigs. Una vez iniciado el tratamiento sistémico la paciente presentó, como una complicación de su enfermedad de base, hallazgos compatibles con una linfangitis carcinomatosa, que condicionó la necesidad de oxigenoterapia domiciliaria

We present the clinical case of a young patient who came to the emergency department due to dyspnea, showing a massive right pleural effusion on the chest radiograph and an ovarian mass on the transvaginal ultrasound, performed after the finding of a positive pregnancy test. In the thoraco-abdominal CT scan, a thickening of the gastric mucosa was also observed, which was valued by gastroscopy, with a positive biopsy for adenocarcinoma of cells in the signet ring. Given these findings, the diagnosis of Krukenberg tumor was confirned, a rare entity with an exceptional form of presentation in the form of false Meigs syndrome. Once the systemic treatment was begun the patient presented, as a complication of the underlying disease, findings compatible with a carcinomatous lymphangitis, which conditioned the need for home oxygen therapy

Hemorragia obstétrica de causa inesperada. Tumor de Krukenberg / Unexpected obstetric haemorrhage. Krukenberg tumour

La hemorragia obstétrica puede poner en riesgo la vida de la madre y del feto y a menudo se presenta de forma inesperada sin claros factores de riesgo. Su identificación precoz contribuye a no demorar las medidas de reanimación. Se presenta el caso de una rotura de metástasis ovárica durante el trabajo de parto responsable de sangrado masivo que obligó a una cesárea por pérdida de bienestar fetal, un inicio no descrito previamente en el tumor de Krukenberg. Los tumores malignos del embarazo son infrecuentes y difíciles de diagnosticar ya que sus manifestaciones clínicas a menudo se solapan con las del propio embarazo (dispepsia, náuseas y distensión abdominal). Un retraso en el diagnóstico comporta un pronóstico infausto a largo plazo. Se revisan las causas de sangrado obstétrico, subrayando la rareza del tumor de Krukenberg concomitante al embarazo (AU)

Obstetric haemorrhage can endanger the lives of mother and foetus. It often occurs unexpectedly without clear predictors. A high degree of suspicion helps to avoid delaying resuscitation measures. We present the case of a ruptured ovarian metastasis that occurred during labour. It caused a massive bleed forcing a caesarean section due to non-reassuring foetal status. This was an unprecedented and undescribed onset of Krukenberg tumour formation. Malignant tumours in pregnancy are rare and difficult to diagnose due to their clinical manifestations which often overlap with those of pregnancy itself (dyspepsia, nausea and bloating). Despite the available therapeutic measures, a delay in diagnosis is a determining factor for long-term prognosis. We review the causes of obstetric bleeding, and underline how rare Krukenberg tumours concomitant to pregnancy are (AU)

In utero virilization secondary to a maternal Krukenberg tumor: case report and review of literature.

BACKGROUND: Krukenberg tumors are ovarian metastatic adenocarcinomas with a primary origin usually located in the stomach, colon, gallbladder, pancreas, or breast. Occasionally, these tumors produce virilization in the affected individual due to androgen production by luteinization of the tumoral stroma. It is believed that during pregnancy these tumors are more likely to increase androgen production due to the elevated levels of human chorionic gonadotropin (hCG). High maternal androgens can cross the placenta producing virilization of the female fetus. CASE PRESENTATION: A 46,XX newborn female, whose mother was diagnosed with a metastatic ovarian tumor during her second trimester of gestation associated with worsening hirsutism and acne, was found to have ambiguous genitalia at birth. Testosterone levels in both the mother and infant were elevated. Follow-up laboratory tests showed progressive normalization of circulating androgens after delivery. CONCLUSIONS: Krukenberg tumors are rare and may produce virilization of the mother and the female fetus when present during pregnancy.

Unexpected obstetric haemorrhage. Krukenberg tumour. / Hemorragia obstétrica de causa inesperada. Tumor de Krukenberg.

Obstetric haemorrhage can endanger the lives of mother and foetus. It often occurs unexpectedly without clear predictors. A high degree of suspicion helps to avoid delaying resuscitation measures. We present the case of a ruptured ovarian metastasis that occurred during labour. It caused a massive bleed forcing a caesarean section due to non-reassuring foetal status. This was an unprecedented and undescribed onset of Krukenberg tumour formation. Malignant tumours in pregnancy are rare and difficult to diagnose due to their clinical manifestations which often overlap with those of pregnancy itself (dyspepsia, nausea and bloating). Despite the available therapeutic measures, a delay in diagnosis is a determining factor for long-term prognosis. We review the causes of obstetric bleeding, and underline how rare Krukenberg tumours concomitant to pregnancy are.

Pseudo-Meigs' syndrome caused by a Krukenberg tumour of gastric cancer.

A 50-year-old woman who presented with a one-month history of abdominal fullness and dyspnoea was admitted to our hospital. Esophagogastroduodenoscopy showed the scirrhous-type gastric cancer on the greater curvature of the gastric body. Computed tomography revealed bilateral large ovarian tumours with massive right pleural effusion and ascites. A repeated cytological examination of pleural effusion and ascites revealed no malignant cells. The definitive diagnosis of pseudo-Meigs' syndrome was made by confirming the fact that pleural effusion and ascites disappeared after bilateral oophorectomy. Resection of ovarian tumours may also lead to long-term survival, even in the patients with pseudo-Meigs' syndrome caused by gastric cancer.

Metastatic Ovarian Tumor Masquerading as Atypical Pneumonia.

Krukenberg tumor is a malignancy in the ovary from a primary lesion in the gastrointestinal tract and a metastatic signet ring cell adenocarcinoma to the ovary. Stomach is the most common primary site, but other organs can serve as a primary site. The lymphatic system is the most likely route for metastasis. CA 125 levels can be used for screening for early detection of ovarian metastasis as well as for monitoring the course of disease. The prognosis of Krukenberg tumor is poor and no curative treatment is currently available.

Krukenberg tumor presenting with amenorrhea as the sole initial symptom: Case report and review of the literature.

Krukenberg tumor (KT), mostly originates from gastric cancer, is the metastatic tumor of ovaries accounting for 1-2% of all ovarian cancer. Common presenting symptoms include abdominal pain, distension, and ascites. Rests of the patients have non-specific gastrointestinal symptoms including dyspepsia, weight loss, nausea and vomiting. Gynecologic symptoms such as virilization, menstrual bleeding or irregularity and amenorrhea are much less frequent in the literature cases. Here, we present an unusual case of KT presented with amenorrhea as the sole initial symptom.

Tumor de Krukenberg del ovario asociado a teratoma maduro / Krukenberg tumor of the ovary associated with mature teratoma

Se reporta un caso excepcional de tumor de Krukenberg ovárico bilateral asociado a teratoma maduro encontrado en una mujer de 54 años. La ecografía mostró al lado derecho tumor ovárico sólido de 55 mm y al lado izquierdo tumor quístico de 125 mm. Se realizó histerectomía total, salpingooforectomía bilateral, resección del epiplón mayor y muestras peritoneales. Al tercer día postcirugía, la paciente presentó signos de tromboembolismo pulmonar masivo y aunque recibió terapia anticoagulante falleció al quinto día postoperatorio. El estudio histológico mostró infiltración masiva de carcinoma de células en anillo positivas para citoqueratina en ambos ovarios. El ovario derecho mostró la forma sólida clásica del tumor de Krukenberg mientras que el ovario izquierdo correspondió a un quiste dermoide con infiltración tumoral de carcinoma de células en anillo en la pared.

An exceptional case of bilateral Krukenberg tumor of the ovary associated with mature teratoma presented in a 54 years old patient is reported. The ultrasound showed a 55 mm solid right ovarian tumor and a 125 mm left cystic ovarian tumor. Hysterectomy and bilateral salpingoophorectomy was performed including omental resection and peritoneal biopsies. Massive pulmonary embolism was detected in the third day after the surgery. Even anticoagulant therapy was established the patient died in the fifth postoperative day. The histological study revealed massive infiltration of signet ring cell carcinoma with positive expression for cytokeratin in both ovaries. The right ovary showed the classical solid form of the tumor. The left ovary was a dermoid cyst with signet ring cell carcinoma infiltrating the cystic wall.

Krukenberg tumor presenting as back pain and a positive urine pregnancy test: a case report and literature review.

A Krukenberg tumor is a rare and potentially deadly cause of elevated serum ß-hCG as part of a paraneoplastic syndrome. This study aims to describe the unusual case of a 36-year-old woman that presented to the Emergency Department (ED) with back pain and a positive urine pregnancy test. Assessment revealed no intrauterine pregnancy and a small left ovarian cyst. Further investigation showed moderately differentiated gastric adenocarcinoma with distant metastases to the spine. The patient died less than 3 months after her first presentation to the ED. Paraneoplastic syndrome, albeit rare, should be considered in the differential diagnosis of elevated ß-hCG due to the high mortality associated with Krukenberg tumors.

Tumor de Krukenberg tras by-pass gástrico por obesidad mórbida. Cirugía bariátrica y cáncer de estómago / Krukenberg tumor after gastric bypass for morbid obesity. Bariatric surgery and gastric cancer

El by-pass gástrico es una de las técnicas quirúrgicas más em - pleadas en la cirugía de la obesidad mórbida. La neoplasia del remanente gástrico es una complicación poco frecuente (se han descrito seis casos a este nivel), pero con consecuencias importantes para la supervivencia de los pacientes. Presentamos el caso de una paciente que desarrolló un adenocarcinoma en el remanente gástrico tres años tras la cirugía bariátrica, descubriéndose como hallazgo casual tras una cirugía ginecológica por miomas uterinos. Se revisan las diferentes modalidades diagnósticas del segmento excluido (AU)

Gastric by-pass is one of the most performed surgical procedure in bariatric surgery. Neoplasm within gastric remnant is a slightly frequent complication (only six cases have been described) but with important survival consequences. We present a case of a patient who developed an adenocarcinoma in excluded stomach, after three years of bariatric surgery; the tumor was incidentally discovered after a gynecological surgery for uterine myomas. Different diagnostic modalities for the excluded stomach were analyzed (AU)

Dyspnoea and the ovaries: a rare presentation of Krukenberg tumour.

Krukenberg tumour is a metastatic signet-ring adenocarcinoma of the ovary, usually with a gastrointestinal primary detected metachronously or synchronously. We present here a case of a 48 year-old woman who presented with a prolonged history of dyspnoea on exertion. Workup had revealed a pelvic mass. Thoracocentesis of her pleural effusion, with cytology, and pathology reports from her total abdominal hysterectomy with bilateral salpingo-oophorectomy revealed a carcinoma with signet-ring cells. Immunostains were positive for CDX2, CK7 and CK20, which was highly suggestive of a gastric primary. Colonoscopy was negative, and an oesophagogastroduodenoscopy revealed a few small crater ulcers, the biopsy of which was negative for cancer. A right-sided pleurodesis was performed for the unremitting malignant effusion, and a PleurX catheter was placed in her left pleural space. She was discharged home with a very poor prognosis.

Tumor de Krukenberg secundario a carcinoma de colon durante el embarazo / Krukenberg tumor secondary to carcinoma of the colon during pregnancy

El tumor de Krukenberg se define como aquel tumor metastásico en ovario uni o bilateral que contiene cantidades importantes de células en anillo de sello y cuyo origen es principalmente digestivo. La incidencia de tumores metastásicos en ovario es muy pequeña (1-5%); asimismo la coincidencia de una masa ovárica de características malignas metastásicas con una gestación es ínfima. Presentamos el caso de una mujer de 19 años que tras el diagnóstico de un adenocarcinoma mucinoso de colon, a los 18 meses presenta un tumor de Krukenberg en la semana 29 de gestación. En un primer momento se le realizó cesárea junto a cirugía resectiva del tumor. En un segundo tiempo se le practicó cirugía citorreductora asociada a quimioterapia intraperitoneal intraoperatoria hipertérmica, encontrándose actualmente en remisión clínica y en seguimiento por el servicio de oncología (AU)

Krukenberg tumor is defined as a metastatic uni- or bilateral ovarian tumor that contains significant amounts of signet ring cells and whose origin is mainly gastrointestinal. The incidence of metastatic tumors of the ovary is very small (1-5%), and that of the concurrence of an ovarian mass with metastatic malignant features and pregnancy is negligible. We report the case of a 19-year-old woman who, 18 months after diagnosis of a mucinous adenocarcinoma of the colon, was diagnosed with a Krukenberg tumor in the 29th week of pregnancy. Initially, cesarean section together with tumoral resection was performed. In a second stage, cytoreductive surgery was performed with hyperthermic intraoperative intraperitoneal chemotherapy. The patient is currently in clinical remission and is monitored by the oncology service (AU)

Excessive hirsutism in pregnancy because of Krukenberg tumor.

Krukenberg tumor is an ovarian metastatic tumor which may rarely develop during pregnancy. The diagnosis of this tumor is often overlooked by the signs and symptoms of pregnancy and therefore delayed. The prognosis is universally poor and most patients die within one year of diagnosis.We present a case of a pregnant woman who was admitted for threatened premature birth and diagnosed with Krukenberg tumor. Virilization symptoms initiated clinical and laboratory investigation and eventually the diagnosis of Krukenberg tumor was confirmed. The woman delivered a healthy infant and after that she received palliative treatment.

Virilizing ovarian Krukenberg tumor in a 27-year-old pregnant woman. A case report and literature review.

A case is reported of a 27-year-old pregnant woman with ovarian tumors, measuring 12 cm and 11.5 cm in the greatest diameter, discovered during investigation for virilization symptoms. Termination of the pregnancy at the 22nd week of gestation and tumorectomy with both adnexa were performed, with the provisional diagnosis of arrhenoblastoma. Pathological examination of the tumors showed typical Krukenberg neoplasms and subsequent upper GI tract endoscopy revealed a gastric cancer that was excised. The pathological examination revealed a diffuse type gastric adenocarcinoma with signet ring morphology, similar to ovarian tumors. In any case of ovarian tumor with unusual hormonal manifestations, in addition to hormonally active sex cord-stromal neoplasms, metastatic ovarian tumors must be considered as well, especially in cases of bilateral tumors.

MDP uptake in peritoneal carcinomatosis and Krukenberg tumors from mucinous adenocarcinoma.

Altered biodistribution of Tc-99m methylene diphosphonate is a common occurrence on bone scintigraphy and mucin-producing neoplasms of the gastrointestinal tract are associated with dystrophic uptake. In addition to the uptake in the primary tumor, activity has been reported in metastasis within lymph nodes and liver. We present a case of Tc-99m methylene diphosphonate uptake in peritoneal carcinomatosis and metastatic Krukenberg tumors from a primary mucinous adenocarcinoma of the descending colon. Each of these findings is uncommon and their combination in this case is particularly unique.

Krukenberg tumour simulating uterine fibroids and pelvic inflammatory disease.

OBJECTIVE: To report a case of cancer of the colon which presented as secondaries to the ovaries. METHOD: Case report. SUMMARY: The case presented is that of a 39-year-old female who presented with lower abdominal pain and a multinodular pelvic mass which led to an initial diagnosis of multiple uterine fibroids and pelvic inflammatory disease. The presence of a colonic mass was first suggested by ultrasound. Laparotomy revealed carcinoma of the colon with bilateral krukenberg's tumour and an insignificant fibroleiomyoma. CONCLUSION: This case is reported to alert practitioners that all multinodular pelvic masses should not be assumed to be multiple fibroids.

A case of virilization induced by a Krukenberg tumor from gastric cancer.

BACKGROUND: The Krukenberg tumor represents ovarian metastases associated with gastric cancer or other gastrointestinal malignancies. Histology shows typical mucus-production and numerous signet-ring cells. Occasionally Krukenberg tumors have endocrine function and, as a consequence, some patients demonstrate hirsutism and virilization. CASE PRESENTATION: Here we report a case of virilization associated with an extensive gastric adenocarcinoma and Krukenberg tumor in a premenopausal woman. Virilization occurred three months after diagnosis of gastric cancer and the ovarian tumors. Palliative chemotherapy was initiated as primary therapy, but gastric outlet obstruction required a gastrojejunostomy. In addition, oopherectomy was performed to relieve abdominal tension and to abate hormonal effects. It is likely that virilization of the patient could have been prevented by earlier oopherectomy prior to development of hormone production. CONCLUSION: Despite the limitation in survival time early oopherectomy should be considered to prevent the development of virilization even in palliative situations if a Krukenberg tumor is diagnosed with gastric cancer.

Síndrome de Pseudomeigs en paciente con tumor de Krukenberg / No disponible

Se presenta el caso de una mujer de 51 años con antecedente de Linfoma no Hodking y adenocarcinoma gástrico con células en anillo de sello. Acude a nuestro centro por llevar 20 meses con disnea por derrame pleural, linfedema en ambas piernas y ascitis. Se detectan en la TC y en la ecografía dos masas anexiales bilaterales, que se biopsian. El diagnóstico histológico es metástasis ovárica bilateral por adenocarcinoma de células en anillo de sello (tumor de Krukenberg). Esta paciente presenta un síndrome de Pseudomeigs, que comprende un tumor maligno de ovario asociado con ascitis y derrame pleural con citología maligna negativa. En pacientes oncológicos con ascitis y derrame pleural benignos se debería considerar en el diagnóstico diferencial el síndrome de PseudoMeigs

We report the case of a fi ftyone-year-old woman with a past medical history of Linfoma no Hodking and a gastric adenocarcinoma with signet ring cells. She came to our institution with a twenty month history of dysnea secondary to pleural effussion, bilateral lower extremity edema and probably had ascitis. On CT and US two bilateral pelvic masses were found and biopsied. The anatomopathological analysis showed bilateral ovarian implants from signet ring cell adenocarcinoma (Krukenberg tumor). This patient developed a PseudoMeigs syndrome consisting on malignant ovarian tumor asociated with ascitis and pleural effusion without malignant cells. Oncological patients who present with ascitis and benign pleural effusion, the diagnosis of PseudoMeigs syndrome should be considered