Asunto(s)
Vesícula/etnología , Vesícula/genética , Epidermólisis Ampollosa/etnología , Epidermólisis Ampollosa/genética , Proteínas de la Membrana/genética , Mutación/genética , Proteínas de Neoplasias/genética , Enfermedades Periodontales/etnología , Enfermedades Periodontales/genética , Trastornos por Fotosensibilidad/etnología , Trastornos por Fotosensibilidad/genética , Vesícula/diagnóstico , Epidermólisis Ampollosa/diagnóstico , Femenino , Heterocigoto , Homocigoto , Humanos , Irán , Masculino , Linaje , Enfermedades Periodontales/diagnóstico , Trastornos por Fotosensibilidad/diagnóstico , Diagnóstico PrenatalAsunto(s)
Proteínas de la Membrana/genética , Mutación/genética , Proteínas de Neoplasias/genética , Vesícula/diagnóstico , Vesícula/etnología , Vesícula/genética , Epidermólisis Ampollosa/diagnóstico , Epidermólisis Ampollosa/etnología , Epidermólisis Ampollosa/genética , Exones/genética , Femenino , Humanos , Masculino , Persona de Mediana Edad , Linaje , Enfermedades Periodontales/diagnóstico , Enfermedades Periodontales/etnología , Enfermedades Periodontales/genética , Trastornos por Fotosensibilidad/diagnóstico , Trastornos por Fotosensibilidad/etnología , Trastornos por Fotosensibilidad/genética , EspañaRESUMEN
OBJECTIVE: To evaluate corneal endothelial bleb response to wear of silicone-hydrogel contact lenses in eyes of East Asian subjects. METHODS: A total of 24 subjects of East Asian origin, attended 3 separate sessions for a prospective, single-centre, trial. The following contact lenses were used: ACUVUE ADVANCE with HYDRACLEAR (ADVANCE, -3 dioptres), ACUVUE OASYS with HYDRACLEAR Plus (OASYS, -3 dioptres), Focus NIGHT & DAY (NIGHT & DAY, -3 dioptres) and SofLens 38 (+3 dioptres). A modified Balaam's crossover design was used to randomize presentation of sessions and contact lenses within sessions. Session 1 was a comparison between OASYS and SofLens 38 under closed eye conditions, session 2 was a comparison between ADVANCE and NIGHT & DAY under open eye conditions, and session 3 was a comparison between OASYS and NIGHT & DAY worn under closed eye conditions. Corneal endothelial images were captured with the Topcon SP-3000P noncontact Specular Microscope before lens wear, after 20 mins of wear with lenses on and 5 and 10 mins later after lens removal. Blebs were manually identified on these digital images by a masked observer. The area of blebs and total area under consideration were derived using ImageNet software and used to calculate percentage area of blebs. A boundary of equivalence of 1% was used as a clinically significant bleb area difference, and two-sided 95% confidence intervals were utilized to evaluate differences between lenses within each session. RESULTS: In session 1, SofLens 38 produced a mean percentage area of blebs of 8.0% under closed eye conditions, which was significantly different to that produced by OASYS (1.6%). In session 2, both Advance and Night & Day produced a mean percentage bleb area of 0.4% under open eye conditions. In session 3, OASYS and NIGHT & DAY produced statistically similar mean percentage bleb areas of 1.7% and 2.0%, respectively. CONCLUSIONS: The similarity of bleb responses induced by the silicone-hydrogel lenses under the tested wearing conditions is consistent with the proposition that increases in Dk/t above a certain level will produce minimal change in corneal physiologic conditions compared with that when no lens is worn.
Asunto(s)
Pueblo Asiatico , Vesícula/patología , Lentes de Contacto/efectos adversos , Endotelio Corneal/patología , Hidrogel de Polietilenoglicol-Dimetacrilato , Siliconas , Adolescente , Adulto , Vesícula/etnología , Vesícula/etiología , Estudios Cruzados , Diseño de Equipo , Femenino , Humanos , Masculino , Persona de Mediana Edad , Factores de Tiempo , Adulto JovenRESUMEN
PURPOSE: To investigate ethnic differences in corneal endothelia bleb formation and corneal swelling during contact lens wear under closed-eye conditions, with the use of lenses of varying oxygen transmissibilities (Dk/L) in Asian and non-Asian subjects METHODS: Asian and non-Asian contact-lens naive subjects were fitted with one of four different types of contact lenses at each 20-minute session. During lens wear, the eyelid was closed Endothelial bleb formation was determined by specular microscopy or confocal microscopy immediately on eye opening. Some Asian contact-lens naive subjects were asked to wear one of two types of lenses (Dk/L values of 24 and 175) on each eye for 1 hour Corneal swelling was determined immediately after opening of the eyes. RESULTS: Asian subjects had a significantly higher degree of endothelial bleb formation than the non-Asian population for all closed eye conditions, p=0.0001. There was no significant difference in endothelial bleb formation between closed eves with or without lenses in the non-Asian population. There was a significantly higher degree of bleb formation with low Dk/L lenses, < or = 40, compared to high Dk/L lenses, > or = 110, in Asian subjects, p=0.0001. CONCLUSIONS: There is a significant difference between Asian and non-Asian subjects in the corneal response to stress. Under a closed eyelid only contact lenses with very high levels of Dk/L do not cause cornea stress in Asian patients.