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1.
Molecules ; 26(4)2021 Feb 20.
Artículo en Inglés | MEDLINE | ID: mdl-33672486

RESUMEN

Medicinal plants and their derived compounds have drawn the attention of researchers due to their considerable impact on human health. Among medicinal plants, mint (Mentha species) exhibits multiple health beneficial properties, such as prevention from cancer development and anti-obesity, antimicrobial, anti-inflammatory, anti-diabetic, and cardioprotective effects, as a result of its antioxidant potential, combined with low toxicity and high efficacy. Mentha species are widely used in savory dishes, food, beverages, and confectionary products. Phytochemicals derived from mint also showed anticancer activity against different types of human cancers such as cervix, lung, breast and many others. Mint essential oils show a great cytotoxicity potential, by modulating MAPK and PI3k/Akt pathways; they also induce apoptosis, suppress invasion and migration potential of cancer cells lines along with cell cycle arrest, upregulation of Bax and p53 genes, modulation of TNF, IL-6, IFN-γ, IL-8, and induction of senescence phenotype. Essential oils from mint have also been found to exert antibacterial activities against Bacillus subtilis, Streptococcus aureus, Pseudomonas aeruginosa, and many others. The current review highlights the antimicrobial role of mint-derived compounds and essential oils with a special emphasis on anticancer activities, clinical data and adverse effects displayed by such versatile plants.


Asunto(s)
Antibacterianos/farmacología , Antineoplásicos Fitogénicos/farmacología , Antioxidantes/farmacología , Mentha/química , Aceites Volátiles/farmacología , Fitoquímicos/farmacología , Antibacterianos/química , Antibacterianos/aislamiento & purificación , Antineoplásicos Fitogénicos/química , Antineoplásicos Fitogénicos/aislamiento & purificación , Antioxidantes/química , Antioxidantes/aislamiento & purificación , Bacterias/efectos de los fármacos , Compuestos de Bifenilo/antagonistas & inhibidores , Proliferación Celular/efectos de los fármacos , Humanos , Aceites Volátiles/química , Aceites Volátiles/aislamiento & purificación , Fitoquímicos/química , Fitoquímicos/aislamiento & purificación , Picratos/antagonistas & inhibidores
2.
Carbohydr Polym ; 260: 117834, 2021 May 15.
Artículo en Inglés | MEDLINE | ID: mdl-33712171

RESUMEN

This study reports preparation and physicochemical characterization of natural antimicrobials (Origanum Syriacum essential oil (OSEO), shrimp chitosan nanoparticles (CSNPs)) and new imidazolium ionic liquid-supported Zn(II)Salen. These antimicrobials were separately or co-encapsulated by CSNPs to fabricate novel antimicrobial nanoplatforms "NPFs" (OSEO-loaded CSNPs (NPF-1), Zn(II)Salen-loaded CSNPs (NPF-2), and Zn(II)Salen@OSEO-loaded CSNPs (NPF-3)). The finding of loading, encapsulation, and antimicrobial release studies confirm the suitability of CSNPs for nanoencapsulation of Zn(II)Salen and OSEO. All NPFs can significantly suppress the growth of microbial species with performances dependent upon the microbial strain and nanoplatform concentration. The susceptibility of microbes toward new antimicrobials was as follows; Gram-positive bacteria > Gram-negative bacteria > fungi. The amazing physicochemical features of new nanoplatforms and their bioactive ingredients (Zn(II)Salen, OSEO, and CSNPs) signify the importance of our designs for developing a new generation of nanopharmaceuticals supported both natural products and biogenic ionic metal cofactors, targeting the multidrug resistant (MDR) pathogens.


Asunto(s)
Antiinfecciosos/química , Quitosano/química , Etilenodiaminas/química , Nanopartículas/química , Aceites Volátiles/química , Antiinfecciosos/metabolismo , Antiinfecciosos/farmacología , Portadores de Fármacos/química , Liberación de Fármacos , Etilenodiaminas/metabolismo , Hongos/efectos de los fármacos , Bacterias Gramnegativas/efectos de los fármacos , Bacterias Grampositivas/efectos de los fármacos , Imidazoles/química , Aceites Volátiles/metabolismo , Origanum/metabolismo , Tamaño de la Partícula , Temperatura , Zinc/química
3.
Molecules ; 26(5)2021 Feb 26.
Artículo en Inglés | MEDLINE | ID: mdl-33652584

RESUMEN

The purpose of the research was to examine the protective effect of essential oil from Thymus serrulatus Hochst. ex Benth. (TSA oil) against cadmium (Cd)-induced renal toxicity. The experimental protocol was designed using 30 healthy adult Wistar albino rats allocated into five groups containing six animals in each group. Group 1 was treated as normal control and groups 2, 3, 4, and 5 were treated with cadmium chloride (CdCl2, 3 mg/kg, IP) for 7 days. Group 3 was also treated with silymarin (100 mg/kg, PO) as a standard group, while groups 4 and 5 were administered with TSA oil at doses of 100 and 200 mg/kg PO, respectively. The nephrotoxicity was measured with various parameters such as kidney function markers, oxidative stress markers (glutathione (GSH) and malondialdehyde (MDA)), and messenger ribonucleic acid (mRNA) expression levels of inflammatory factors. The histological studies were also evaluated in the experimental protocol. The CdCl2-treated groups showed a significant increase in the levels of serum kidney function markers along with MDA levels in kidney homogenate. However, renal GSH level was found to be reduced significantly. It was found that CdCl2 significantly upregulated the nuclear factor levels of kappaB (NF-κB p65), inducible nitric oxide synthase (iNOS), and small mothers against decapentaplegic (Smad2) as compared to the normal control group. On the other hand, TSA oil significantly improved the increased levels of serum kidney function markers, non-enzymatic antioxidants, and lipid peroxidation. In addition, TSA oil significantly downregulated the increased expression of NF-κB p65, iNOS, and Smad2 in Cd-intoxicated rats. Moreover, the histological changes in the tissue samples of the kidney of Cd-treated groups were significantly ameliorated in the silymarin- and TSA-oil-treated groups. The present study reveals that TSA oil ameliorates Cd-induced renal injury, and it is also proposed that the observed nephroprotective effect could be due to the antioxidant potential of TSA oil and healing due to its anti-inflammatory action.


Asunto(s)
Enfermedades Renales/tratamiento farmacológico , Aceites Volátiles/química , Estrés Oxidativo/efectos de los fármacos , Thymus (Planta)/química , Animales , Antioxidantes/química , Antioxidantes/farmacología , Cadmio/toxicidad , Regulación de la Expresión Génica/efectos de los fármacos , Humanos , Riñón/efectos de los fármacos , Riñón/patología , Enfermedades Renales/inducido químicamente , FN-kappa B/genética , Óxido Nítrico Sintasa de Tipo II/genética , Aceites Volátiles/farmacología , Ratas , Proteína Smad2/genética
4.
Molecules ; 26(4)2021 Feb 19.
Artículo en Inglés | MEDLINE | ID: mdl-33669825

RESUMEN

The aim of the present research was to determine the chemical composition and the cytotoxic effects of Tetraclinis articulata trunk bark essential oil (HEE) obtained by steam distillation and five fractions obtained by normal phase silica chromatographic separation. Chemical analysis allowed the identification of 54 known compounds. Relatively high amounts of oxygenated sesquiterpenes (44.4-70.2%) were detected, mainly consisting of caryophyllene oxide (13.1-26.6%), carotol (9.2-21.2%),14-hydroxy-9-epi-(E)-caryophyllene (3.2-15.5%) and humulene epoxide II (2.6-7.2%). The cytotoxic activity against human mammary carcinoma cell lines (MDA-MB-231) and colorectal carcinoma cell lines (SW620) of the essential oil and its fractions were assessed. All the samples displayed moderate to weak activity compared to 5-fluorouracil. The colorectal carcinoma cell line was relatively more sensitive to the essential oil and its fractions compared to the breast cancer cell line, showing IC50 values from 25.7 to 96.5 µg/mL. In addition, the essential oil and its fraction E.2 revealed a cytotoxic activity against colorectal carcinoma cell line, with IC50 values lower than 30 µg/mL. This is the first report on the chemical composition and cytotoxic activity of the trunk bark essential oil of T. articulata.


Asunto(s)
Cupressaceae/química , Cupressaceae/crecimiento & desarrollo , Aceites Volátiles/química , Aceites Volátiles/farmacología , Corteza de la Planta/química , Muerte Celular/efectos de los fármacos , Línea Celular Tumoral , Proliferación Celular/efectos de los fármacos , Fraccionamiento Químico , Humanos , Concentración 50 Inhibidora , Túnez
5.
Molecules ; 26(4)2021 Feb 11.
Artículo en Inglés | MEDLINE | ID: mdl-33670315

RESUMEN

Arabian flora is a rich source of bioactive compounds. In this study, we investigated three aromatic plant species with the aim of finding valuable sources of antimicrobial agents against common pathogenic microorganisms. We focused especially on microorganisms, which cause outbreaks of infectious disease during mass gatherings and pilgrimages season in Saudi Arabia. The essential oils of three aromatic plant species were hydrodistilled from flowering aerial parts of Lavandula pubescens Decne. and Pulicaria incisa subsp. candolleana E.Gamal-Eldin, and from leaves, stems, ripe and unripe fruits of Juniperus procera Hochst. Ex Endl. They were subsequently analyzed by gas chromatography-mass spectrometry (GC-MS). The main constituents of L. pubescens were found to be carvacrol (55.7%), methyl carvacrol (13.4%), and ß-bisabolene (9.1%). P. incisa subsp. Candolleana essential oil was rich in linalool (33.0%), chrysanthenone (10.3%), eugenol (8.9%), and cis-chrysanthenol (8.0%); the major components of J. procera essential oil were α-pinene (31.3-62.5%) and δ-3-carene (7.3-30.3%). These essential oils were tested against thirteen American Type Culture Collection (ATCC) strains of Gram-positive and Gram-negative bacteria using the agar diffusion assay. The only effective essential oil was that of L. pubescens and the most sensitive strains were Acinetobacter baumannii, Salmonella typhimurium, Shigella sonnei, Enterococcus faecalis and Staphylococcus epidermidis. Carvacrol, the major constituent of L. pubescens, was tested on these strains and was compared with vancomycin, amikacin, and ciprofloxacin. The Minimum Inhibitory Concentration (MIC) and Minimum Bactericidal Concentration (MBC) assays of L. pubescens essential oil and carvacrol revealed that Gram-negative strains were more susceptible than the Gram-positive ones.


Asunto(s)
Juniperus/química , Lavandula/química , Aceites Volátiles/química , Aceites Vegetales/química , Pulicaria/química , Antibacterianos/química , Antibacterianos/farmacología , Cimenos/química , Cimenos/farmacología , Enterococcus faecalis/efectos de los fármacos , Bacterias Gramnegativas/efectos de los fármacos , Bacterias Grampositivas/efectos de los fármacos , Humanos , Pruebas de Sensibilidad Microbiana , Aceites Volátiles/farmacología , Componentes Aéreos de las Plantas/química , Hojas de la Planta/química , Aceites Vegetales/farmacología , Arabia Saudita , Staphylococcus aureus/efectos de los fármacos
6.
Molecules ; 26(4)2021 Feb 18.
Artículo en Inglés | MEDLINE | ID: mdl-33670506

RESUMEN

The aim of this study was to evaluate occurrence of T. pulegioides α-terpinyl acetate chemotype, as source of natural origin α-terpinyl acetate, to determine its phytotoxic and antimicrobial features. Were investigated 131 T. pulegioides habitats. Essential oils were isolated by hydrodistillation and analyzed by GC-FID and GC-MS. Phytotoxic effect of essential oil of this chemotype on monocotyledons and dicotyledons through water and air was carried out in laboratory conditions; the broth microdilution method was used to screen essential oil effect against human pathogenic microorganisms. Results showed that α-terpinyl acetate was very rare compound in essential oil of T. pulegioides: it was found only in 35% of investigated T. pulegioides habitats. α-Terpinyl acetate (in essential oil and pure) demonstrated different behavior on investigated plants. Phytotoxic effect of α-terpinyl acetate was stronger on investigated monocotyledons than on dicotyledons. α-Terpinyl acetate essential oil inhibited seeds germination and radicles growth for high economic productivity forage grass monocotyledon Poa pratensis, but stimulated seed germination for high economic productive forage legume dicotyledon Trifolium pretense. α-Terpinyl acetate essential oil showed high antimicrobial effect against fungi and dermatophytes but lower effect against bacteria and Candida yeasts. Therefore, T. pulegioides α-terpinyl acetate chemotype could be a potential compound for developing preventive measures or/and drugs for mycosis.


Asunto(s)
Antiinfecciosos/farmacología , Aceites Volátiles/química , Terpenos/farmacología , Thymus (Planta)/química , Geografía , Germinación/efectos de los fármacos , Lituania , Pruebas de Sensibilidad Microbiana , Terpenos/química
7.
Molecules ; 26(4)2021 Feb 12.
Artículo en Inglés | MEDLINE | ID: mdl-33673039

RESUMEN

Psidium (Myrtaceae) comprises approximately 266 species, distributed in tropical and subtropical regions of the world. Psidium taxa have great ecological, economic, and medicinal relevance due to their essential oils' chemical diversity and biological potential. This review reports 18 Psidium species growing around the world and the chemical and biological properties of their essential oils. Chemically, 110 oil records are reported with significant variability of volatile constituents, according to their seasonality and collection sites. Monoterpenes and sesquiterpenes with acyclic (C10 and C15), p-menthane, pinane, bisabolane, germacrane, caryophyllane, cadinane, and aromadendrane skeleton-types, were the primary constituents. The essential oils showed various biological activities, including antioxidant, antifungal, antibacterial, phytotoxic, larvicidal, anti-inflammatory, and cytotoxic properties. This review contributes to the Psidium species rational and economic exploration as natural sources to produce new drugs.


Asunto(s)
Monoterpenos/química , Aceites Volátiles/química , Psidium/química , Sesquiterpenos/química , Antibacterianos/química , Antibacterianos/uso terapéutico , Antiinflamatorios/química , Antiinflamatorios/uso terapéutico , Antifúngicos/química , Antifúngicos/uso terapéutico , Antineoplásicos/química , Antineoplásicos/uso terapéutico , Antioxidantes/química , Antioxidantes/uso terapéutico , Humanos , Monoterpenos/uso terapéutico , Aceites Volátiles/uso terapéutico , Aceites Vegetales/química , Sesquiterpenos/uso terapéutico
8.
Food Chem ; 352: 129319, 2021 Aug 01.
Artículo en Inglés | MEDLINE | ID: mdl-33691215

RESUMEN

Emulsions based on licorice essential oil (LEO) were prepared under different homogenization conditions (ultra-homogenization (U1) or U1 together with sonication (U2)). The obtained emulsions were incorporated into the carboxymethyl cellulose (CMC) film. The results showed that U2 caused significant changes in the size and the surface charge of the emulsions. Remarkable differences in the microstructure were observed between the U1 and the U2 emulsion-based films as revealed by SEM and AFM. Both emulsions reduced the rigidity and increased the flexibility of the films. The film made from the CMC alone had a water vapor permeability (WVP) of 2.66 × 10-9 g m-1 s-1 Pa-1, while the CMC film made from U2 emulsion had a WVP of 1.87 × 10-9 g m-1 s-1 Pa-1. Also, the film containing 0.0125% U1-LEO exhibited antibacterial activity on gram-positive bacteria only while the film containing 0.0125% U2-LEO demonstrated antibacterial activity on both gram-positive and gram-negative bacteria.


Asunto(s)
Antibacterianos/química , Antibacterianos/farmacología , Glycyrrhiza/química , Aceites Volátiles/química , Aceites Volátiles/farmacología , Sonicación , Carboximetilcelulosa de Sodio/química , Emulsiones , Bacterias Gramnegativas/efectos de los fármacos , Bacterias Grampositivas/efectos de los fármacos , Permeabilidad , Vapor
9.
Int J Food Microbiol ; 342: 109071, 2021 Mar 16.
Artículo en Inglés | MEDLINE | ID: mdl-33578302

RESUMEN

Biodegradable films reinforced with bio-nanomaterials are a solution for developing active packaging systems, shelf-life extension and protection of environment against conventional packaging. This study aimed to characterize the biocompatible chitosan (CS) films formulated with nano-liposomal garlic essential oil (NLGEO) and assess the physicho-mechanical, morphology properties and also microbial and chemical changes in chicken fillets during storage time at 4 °C. NLGEO was obtained by thin-layer hydration-sonication method using glycerol and tween 80 as plasticizer and emulsifier, respectively. Different levels (0, 0.5, 1 and 2%) of NLGEO with average size of ~101 nm were added into the chitosan matrix and films fabricated by casting method. The average size, polydispersity index and zeta potential were ~101 nm, 0.127 and -7.23, respectively. Control samples showed higher values for pH, total volatile nitrogen (TVN), peroxide value (PV), thiobarbituric acid-reactive substances (TBARS), and microbial count including total viable count (TVC), coliforms, Staphylococcus aureus and psychrotroph bacteria than treated samples. The films with higher NLGEO content represented stronger inhibitory effects. The incorporation of NLGEO improved the mechanical properties and water resistance of active films. Microstructure analysis also showed a nearly smooth surface morphology and homogenous structure with a good dispersion for NLGEO films. Significant synergistic effects in chemical and bacterial preservation of chicken fillet samples were observed by NLGEO films. The optimal mechanical and barrier properties of chitosan-NLGEO films introduced it a potential active packaging to extend the shelf life of chicken fillet.


Asunto(s)
Quitosano/química , Embalaje de Alimentos/métodos , Nanocompuestos/química , Aceites Volátiles/química , Productos Avícolas/análisis , Productos Avícolas/microbiología , Compuestos Alílicos/química , Animales , Bacterias/clasificación , Bacterias/efectos de los fármacos , Bacterias/crecimiento & desarrollo , Pollos , Quitosano/farmacología , Conservación de Alimentos , Aceites Volátiles/farmacología , Sulfuros/química
10.
Molecules ; 26(3)2021 Jan 30.
Artículo en Inglés | MEDLINE | ID: mdl-33573272

RESUMEN

Pears (Pyrus communis L.) cv. Packham's Triumph are very traditional for human consumption, but pear is a highly perishable climacteric fruit with a short shelf-life affected by several diseases with a microbial origin. In this study, a protective effect on the quality properties of pears was evidenced after the surface application of chitosan-Ruta graveolens essential oil coatings (CS + RGEO) in four different concentrations (0, 0.5, 1.0 and 1.5 %, v/v) during 21 days of storage under 18 °C. After 21 days of treatment, a weight loss reduction of 10% (from 40.2 ± 5.3 to 20.3 ± 3.9) compared to the uncoated pears was evident with CS + RGEO 0.5%. All the fruits' physical-chemical properties evidenced a protective effect of the coatings. The maturity index increased for all the treatments. However, the pears with CS + RGEO 1.5% were lower (70.21) than the uncoated fruits (98.96). The loss of firmness for the uncoated samples was higher compared to the coated samples. The pears' most excellent mechanical resistance was obtained with CS + RGEO 0.5% after 21 days of storage, both for compression resistance (7.42 kPa) and force (22.7 N). Microbiological studies demonstrated the protective power of the coatings. Aerobic mesophilic bacteria and molds were significantly reduced (in 3 Log CFU/g compared to control) using 15 µL/mL of RGEO, without affecting consumer perception. The results presented in this study showed that CS + RGEO coatings are promising in the post-harvest treatment of pears.


Asunto(s)
Quitosano/química , Conservación de Alimentos/métodos , Aceites Volátiles/farmacología , Pyrus/química , Quitosano/farmacología , Respuesta al Choque por Frío/efectos de los fármacos , Frutas/química , Hongos/efectos de los fármacos , Humanos , Aceites Volátiles/química , Aceites Vegetales/química , Pyrus/efectos de los fármacos , Pyrus/microbiología , Ruta/química , Temperatura
11.
Molecules ; 26(2)2021 Jan 08.
Artículo en Inglés | MEDLINE | ID: mdl-33429991

RESUMEN

(1) The metabolic syndrome (MS) promotes acute and chronic infections, due to the pro-inflammatory condition given by TNFα and IL6 or by affecting the microbiota. MS is also correlated with insulin resistance, causing inflammation and infections throughout the organism. (2) The purpose of this study was to track the effect of using the essential oil of Origanum vulgare L. (EOO) as an antibacterial treatment, compared to allopathic treatment with antibiotics in MS patients. A group of 106 people with MS was divided into four subgroups: L1-staphylococcal infection group, L2-Escherichia coli infection group, L3-streptococcal infection group with EOO treatment, and CG-control group without infection or treatment. (3) EOO is responsible for the antibacterial effect, and reduced minor uncomplicated infections. After a 10-day treatment, intestinal side effects were absent, improving the phase angle. (4) The results suggest that EOO may exhibit an antibacterial effect, similar to the antibiotic treatment, without promoting MS-specific dysbiosis, and it also improves the phase angle in patients, which is used as an index of health and cellular function.


Asunto(s)
Antibacterianos , Bacterias/crecimiento & desarrollo , Microbioma Gastrointestinal/efectos de los fármacos , Síndrome Metabólico , Aceites Volátiles , Origanum/química , Antibacterianos/administración & dosificación , Antibacterianos/química , Femenino , Humanos , Masculino , Síndrome Metabólico/tratamiento farmacológico , Síndrome Metabólico/microbiología , Aceites Volátiles/administración & dosificación , Aceites Volátiles/química
12.
Food Chem ; 346: 128970, 2021 Jun 01.
Artículo en Inglés | MEDLINE | ID: mdl-33422919

RESUMEN

Cedarwood essential oil (CEO) has the effect of anti-inflammatory and anti-bacteria. However, the application of this essential oil is limited due to its strong volatility and poor water solubility. To address this issue, two types of oil-in-water CEO emulsions including CEO nanoemulsion (CEO-NE) and CEO Pickering emulsion (CEO-PE) were prepared. CEO-NE with 5% surfactant, had a smaller particle size (135.14 ± 1.1 nm) and higher absolute zeta potential value (32.75 mV) compared with CEO-PE (1% starch) which particle size was 626.21 ± 6.05 nm, zeta potential was 27.58 mV. The stability of CEO-NE and CEO-PE were tested by multiple light scattering, results showed that Turbiscan Stability Index (TSI) value of CEO-NE was much lower than that of CEO-PE. CEO-NE and CEO-PE exerted higher free radical scavenging activities, iron reducing power and antibacterial ability than CEO itself. These results indicated that emulsification is a feasible method to extend application of CEO.


Asunto(s)
Antibacterianos/química , Antioxidantes/química , Emulsiones/química , Aceites Volátiles/química , Antibacterianos/farmacología , Cedrus/metabolismo , Enterobacteriaceae/efectos de los fármacos , Cromatografía de Gases y Espectrometría de Masas , Tamaño de la Partícula , Reología , Resistencia al Corte , Temperatura
13.
Molecules ; 26(3)2021 Jan 27.
Artículo en Inglés | MEDLINE | ID: mdl-33514008

RESUMEN

Fragrance is an integral part of cosmetic products and is often regarded as an overriding factor in the selection of cosmetics among consumers. Fragrances also play a considerable role in masking undesirable smells arising from fatty acids, oils and surfactants that are commonly used in cosmetic formulations. Essential oils are vital assets in the cosmetic industry, as along with imparting pleasant aromas in different products, they are able to act as preservatives and active agents and, simultaneously, offer various benefits to the skin. Moreover, the stimulating demand for natural ingredients has contributed massively to a renewed interest in cosmetic and wellness industries in plant derivatives, especially essential oils. This has led popular cosmetic companies to endorse natural fragrances and opt for minimally processed natural ingredients, given the potentially adverse health risks associated with artificial fragrance chemicals, which are major elements of cosmetics. Among the high-valued essential oils used as fragrances are citrus, lavender, eucalyptus, tea tree and other floral oils, among others, while linalool, geraniol, limonene, citronellol, and citral are much-appreciated fragrance components used in different cosmetics. Thus, this review aimed to highlight the enormous versatility of essential oils as significant sources of natural fragrances in cosmetics and cosmeceuticals. Moreover, a special focus will be laid on the different aspects related to essential oils such as their sources, market demand, chemistry, fragrance classification, aroma profile, authenticity and safety.


Asunto(s)
Productos Biológicos/química , Cosmecéuticos/química , Cosméticos/química , Aceites Volátiles/química , Animales , Humanos , Odorantes/análisis
14.
Int J Biol Macromol ; 170: 593-601, 2021 Feb 15.
Artículo en Inglés | MEDLINE | ID: mdl-33385448

RESUMEN

A novel antimicrobial gel composed of κ-carrageenan (KC) and a cinnamon essential oil (CEO)/hydroxypropyl-ß-cyclodextrin (HPCD) composite was developed. The CEO/HPCD composite was characterized by UV-visible spectrophotometry and Fourier-transform infrared spectroscopy (FT-IR), and the changes in the principal components of CEO upon encapsulation by HPCD were analyzed by gas chromatography-mass spectrometry (GC-MS). The physicochemical properties, release kinetics and antimicrobial activity of the fabricated gels were investigated. The hardness of the KC gels increased with composite concentration in the range of 1.0-3.0% (w/v) and thereafter decreased. A similar trend was observed for the gumminess and chewiness, whereas the gel springiness remained essentially constant. The CEO/HPCD composite also enhanced the fluidity of the system, and the syneresis was positively correlated with the composite concentration. The controlled release of CEO from the gels was affected by the relative humidity (RH) and CEO content. The Ritger-Peppas model indicated that the CEO release kinetics from the gels proceeded through a combination of diffusion and framework erosion. The KC gel containing 5% CEO/HPCD composite displayed effective antimicrobial activity, prolonging the shelf life of sliced bread by at least two days. The reported gels may have potential applications as a promising material for food preservation.


Asunto(s)
2-Hidroxipropil-beta-Ciclodextrina/química , Antibacterianos/química , Carragenina/química , Cinnamomum zeylanicum/química , Hidrogeles/química , Aceites Volátiles/química , Quitosano/química , Embalaje de Alimentos/métodos , Cinética , Pruebas de Sensibilidad Microbiana/métodos , Espectroscopía Infrarroja por Transformada de Fourier/métodos
15.
Molecules ; 26(2)2021 Jan 14.
Artículo en Inglés | MEDLINE | ID: mdl-33466765

RESUMEN

The thermal degradation of linalool-chemotype Cinnamomum osmophloeum leaf essential oil and the stability effect of microencapsulation of leaf essential oil with ß-cyclodextrin were studied. After thermal degradation of linalool-chemotype leaf essential oil, degraded compounds including ß-myrcene, cis-ocimene and trans-ocimene, were formed through the dehydroxylation of linalool; and ene cyclization also occurs to linalool and its dehydroxylated products to form the compounds such as limonene, terpinolene and α-terpinene. The optimal microencapsulation conditions of leaf essential oil microcapsules were at a leaf essential oil to the ß-cyclodextrin ratio of 15:85 and with a solvent ratio (ethanol to water) of 1:5. The maximum yield of leaf essential oil microencapsulated with ß-cyclodextrin was 96.5%. According to results from the accelerated dry-heat aging test, ß-cyclodextrin was fairly stable at 105 °C, and microencapsulation with ß-cyclodextrin can efficiently slow down the emission of linalool-chemotype C. osmophloeum leaf essential oil.


Asunto(s)
Monoterpenos Acíclicos/química , Cinnamomum/química , Aceites Volátiles/química , Hojas de la Planta/química , Aceites Vegetales/química , beta-Ciclodextrinas/química , Cápsulas , Estabilidad de Medicamentos , Calor
16.
Food Chem ; 347: 129051, 2021 Jun 15.
Artículo en Inglés | MEDLINE | ID: mdl-33476921

RESUMEN

A way to reduce food waste is related to the increase of the shelf-life of food as a result of improving the package type. An innovative active food packaging material based on cocrystallization of microbiologically active compounds present in essential oils i.e. carvacrol, thymol and cinnamaldehyde was developed following the Quality by Design principles. The selected active components were used to produce antimicrobial plastic films with solidified active ingredients on their surface characterized by antimicrobial properties against four bacterial strains involved in fruit and vegetable spoilage. The developed packaging prototypes exhibited good antimicrobial activity in vitro providing inhibition percentage of 69 (±15)% by contact and inhibition diameters of 32 (±6) mm in the gas phase, along with a prolonged release of the active components. Finally, the prolonged shelf-life of grape samples up to 7 days at room temperature was demonstrated.


Asunto(s)
Antiinfecciosos/química , Embalaje de Alimentos/métodos , Aceites Volátiles/química , Acroleína/análogos & derivados , Acroleína/química , Acroleína/farmacología , Antiinfecciosos/farmacología , Cristalización , Cimenos/química , Cimenos/farmacología , Escherichia coli/efectos de los fármacos , Microbiología de Alimentos , Calidad de los Alimentos , Pruebas de Sensibilidad Microbiana , Salmonella typhimurium/efectos de los fármacos , Staphylococcus aureus/efectos de los fármacos , Timol/química , Timol/farmacología
17.
Food Chem ; 338: 127724, 2021 Feb 15.
Artículo en Inglés | MEDLINE | ID: mdl-32795878

RESUMEN

Peppermint is widely used medicinal plant with distinguished bioactive potential, therefore, the aim of present work was to develop novel peppermint extracts with high activity by application of traditional and emerging separation techniques. Conventional hydrodistillation and microwave-assisted hydrodistillation (MWHD) were applied for recovery of essential oil (EO), while organic solvent extraction using Soxhlet apparatus, microwave-assisted and ultrasound-assisted process and supercritical fluid extraction (SFE) were applied for non-selective recovery of peppermint lipophilic extracts. Extracts were characterized in terms of terpenoids profile with special emphasis on content of major compounds (mentol, menthone, isomenthol and eucalyptol). Antioxidant activity (DPPH, ABTS, CUPRAC, FRAP, chelating and phosphomolybdenum assay) and enzyme-inhibitory assays (acetylcholinesterase, butyrylcholinesterase, tyrosinase, amylase and glucosidase inhibition) were used for screening of peppermint bioactivity. MWHD was recognized as alternative for traditional process in EO recovery, while SFE extracts were useful for green production of solvent-free peppermint extracts rich in terpenoids and other lipophilic bioactives.


Asunto(s)
Antioxidantes/química , Inhibidores Enzimáticos/química , Mentha piperita/química , Aceites Volátiles/química , Extractos Vegetales/química , Acetilcolinesterasa/química , Acetilcolinesterasa/metabolismo , Cromatografía con Fluido Supercrítico , Inhibidores Enzimáticos/metabolismo , Mentha piperita/metabolismo , Microondas , Polifenoles/química , Polifenoles/aislamiento & purificación , Análisis de Componente Principal , Sonicación , Terpenos/química , Terpenos/aislamiento & purificación
18.
Int J Biol Macromol ; 170: 24-32, 2021 Feb 15.
Artículo en Inglés | MEDLINE | ID: mdl-33333094

RESUMEN

An effective antibacterial system was developed by using clove essential oil Pickering emulsion (CO-PE). The carboxymethyl cellulose sodium modified cellulose nanocrystals (CNC) was used as the stabilizer of CO-PE, which were prepared by environmentally friendly approach of homogenization technology. The factors affecting the formation and stability of CO-PE were studied, such as CNC concentration, homogenization pressure, CO concentration and ionic concentration and pH. And the antibacterial performance of CO-PE against E. coli and S. aureus was investigated by determining the minimal inhibitory concentration (MIC). The results showed that 1% CNC stabilized CO-PE exhibited small droplet size and rough surface, and had good stability at high pH values or salt concentration, owing to the presence of CNC on interface of droplet. And the CNC-stabilized CO-PE exhibited higher antimicrobial activity at equivalent CO concentration, which might be attributed to efficiently adhere to bacterial membrane. Therefore, our research would provide new insights for antibacterial application of Pickering emulsions loading essential oils in the food and other industries.


Asunto(s)
Antibacterianos/química , Celulosa/química , Aceite de Clavo/química , Nanopartículas/química , Aceites Volátiles/química , Antibacterianos/farmacología , Adhesión Bacteriana , Carboximetilcelulosa de Sodio , Aceite de Clavo/farmacología , Evaluación Preclínica de Medicamentos , Emulsiones/química , Escherichia coli/efectos de los fármacos , Concentración de Iones de Hidrógeno , Pruebas de Sensibilidad Microbiana , Aceites Volátiles/farmacología , Concentración Osmolar , Tamaño de la Partícula , Staphylococcus aureus/efectos de los fármacos , Electricidad Estática , Propiedades de Superficie
19.
Carbohydr Polym ; 254: 117314, 2021 Feb 15.
Artículo en Inglés | MEDLINE | ID: mdl-33357877

RESUMEN

Herein, corn starch-based films were prepared by casting method and different concentrations of Zanthoxylum bungeanum essential oil (ZYO) were added to evaluate the morphological, optical, mechanical, and barrier properties of the resultant films. Additionally, structural analysis was carried out via atomic force microscopy and the antibacterial activities against Staphylococcus aureus, Escherichia coli, and Listeria monocytogenes were assessed. We found that the elongation at break was significantly increased (P < 0.05), whereas tensile strength, moisture content, solubility in water, and water vapor permeability rate were significantly decreased (P < 0.05) in films incorporated with ZYO compared with oil-free films. Furthermore, incorporation of ZYO increased the opacity and decreased the gloss of films. Incorporation of ZYO appears to increase the surface roughness and the antibacterial activity of the films. In sum, ZYO can potentially be used in food packaging, particularly food intended to be protected from light and susceptible to spoilage by microorganisms.


Asunto(s)
Antibacterianos/química , Plásticos Biodegradables/química , Aceites Volátiles/química , Almidón/química , Zanthoxylum/química , Escherichia coli/efectos de los fármacos , Embalaje de Alimentos/métodos , Listeria monocytogenes/efectos de los fármacos , Permeabilidad , Solubilidad , Soluciones , Staphylococcus aureus/efectos de los fármacos , Vapor , Propiedades de Superficie , Resistencia a la Tracción , Agua/química
20.
Carbohydr Polym ; 254: 117381, 2021 Feb 15.
Artículo en Inglés | MEDLINE | ID: mdl-33357888

RESUMEN

Sulfonated cellulose nanocrystals (S-CNCs) can be used to encapsulate thyme white essential oil (EO) that is volatile and immiscible with water. S-CNCs form a Pickering emulsion (PE) with EOs and the micron-scale PEs are embedded in sodium alginate (SA) to form macroscale hydrogel beads. The incorporation of PEs with SA is confirmed with FTIR, XRD, SEM and confocal microscopic characterizations and the release behavior is monitored to understand the time-dependent biological activity of the EOs. The larvicidal performance of the SA-PE composite hydrogel beads is investigated with Aedes albopictus (Skuse) larvae. The larvicidal activity is higher for SA/PE hydrogel beads prepared at 0.5 % CaCl2 than 0.75 or 1.0 % CaCl2 due to their higher release rate.


Asunto(s)
Aedes/fisiología , Alginatos/química , Emulsiones/química , Hidrogeles/química , Larva/efectos de los fármacos , Aceites Volátiles/química , Aceites Volátiles/farmacología , Thymus (Planta)/química , Animales , Celulosa/química , Composición de Medicamentos/métodos , Nanopartículas/química , Volatilización , Agua/química
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