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1.
Br J Nurs ; 30(Sup8): 19-24, 2021 Mar 31.
Artículo en Inglés | MEDLINE | ID: mdl-34106773

RESUMEN

Fiona Le Ber answers some of the questions that stoma care nurses may have regarding this novel silicone adhesive based technology, which helps to avoid medical adhesive related skin injury (MARSI) and moisture-associated skin damage (MASD). Whereas hydrocolloid stoma appliances absorb moisture, this has a non-absorptive method of moisture management that prevents peristomal skin becoming damp and excoriated.


Asunto(s)
Adhesivos , Siliconas , Cuidados de la Piel , Estomas Quirúrgicos , Adhesivos/uso terapéutico , Tecnología Biomédica , Humanos , Siliconas/uso terapéutico , Cuidados de la Piel/enfermería
2.
Ann Palliat Med ; 10(5): 5462-5473, 2021 May.
Artículo en Inglés | MEDLINE | ID: mdl-34107709

RESUMEN

BACKGROUND: To evaluate the clinical performance of universal adhesives in etch-and-rinse or self-etch application modes through meta-analysis. METHODS: A literature search was performed by two reviewers in the PubMed, Cochrane Library, and Embase databases (from January 2000 to March 2020). A total of 2,516 non-replicated records were identified and filtered. Studies that evaluated the clinical performance of universal adhesives using etch-and-rinse or self-etch mode were included. RevMan 5.3.5 (Cochrane, London, UK) was used to perform the meta-analysis. RESULTS: A total of 13 studies were included in the meta-analysis. The retention rates were higher in etch-and-rinse groups compared with self-etch groups [odds ratio (OR) =0.35, 95% confidence interval (CI): 0.18-0.71, P=0.003]. The etch-and-rinse approach also had better performance in marginal adaptation (OR =0.49, 95% CI: 0.36-0.67, P<0.001) and marginal staining (OR =0.49, 95% CI: 0.36-0.66, P<0.001). The current data showed a very low incidence rate of secondary caries or postoperative sensitivity, and there were no significant differences in the incidence rates between the etch-and-rinse groups and self-etch groups. DISCUSSION: The current evidence shows that, compared with self-etch approach, the etch-and-rinse approach for universal adhesives provides improved clinical outcomes in terms of retention rates, marginal adaptation, and marginal staining.


Asunto(s)
Adhesivos , Recubrimientos Dentinarios , Humanos , Londres , Ensayo de Materiales , Cementos de Resina
3.
Adv Exp Med Biol ; 1269: 353-357, 2021.
Artículo en Inglés | MEDLINE | ID: mdl-33966242

RESUMEN

The randomized clinical trial, SafeBoosC III, evaluates the effect of treatment guided by cerebral tissue oximetry monitoring in extremely preterm infants. Treatment should be considered, when cerebral oxygen saturation (StO2) drops below a predefined hypoxic threshold. This threshold value differs between different brands of instruments. To achieve high external validity, in this pragmatic trial all commercially available cerebral tissue oximeters have been accepted, provided their specific hypoxic threshold value has been determined in phantom studies. Since most companies produce sensors with an adhesive surface on the patient-contacting side, in the phantom studies these sensors were applied according to the specifications, i.e., the glossy cover was removed from the sensor. However, since the skin of preterm infants is particularly fragile, some neonatologists keep this cover on the adhesive sensors, to avoid the risk of skin injury when removing the sensor. Therefore, the aim of this study was to determine whether keeping this cover on leads to different StO2 values. To evaluate the effect of the cover, we performed multiple deoxygenations in a blood-lipid phantom and compared an INVOS neonatal sensor (Medtronic), with and without the cover, to a reference oximeter (OxiplexTS, ISS). As expected, the relationship of the StO2 between the INVOS neonatal sensor and OxiplexTS was linear (r2 = 0.999) with and without cover, but the cover influenced the linear equation: StO2_INVOS_cover = 1.133*StO2_ISS + 7.1 as opposed to StO2_INVOS_nocover = 1.103*StO2_ISS + 12.0. Furthermore, the hypoxic SafeBoosC III threshold differed as well: 60.3% with cover and 63.8% without cover. In conclusion, keeping the adhesive cover on an INVOS neonatal sensor results in lower measured values. At the hypoxic threshold, this is more than 3% (from 60.3% to 63.8%), and therefore, if clinicians keep the cover on the sensor, they need to be aware of this difference.


Asunto(s)
Adhesivos , Espectroscopía Infrarroja Corta , Encéfalo , Humanos , Lactante , Recién Nacido , Recien Nacido Prematuro , Oximetría , Oxígeno
4.
Biomater Sci ; 9(10): 3645-3649, 2021 May 18.
Artículo en Inglés | MEDLINE | ID: mdl-33949458

RESUMEN

Inspired by the autolysis of shaggy mane, we developed a self-degradable hydrogel as a medical adhesive for skin wounds. The rapid gelation and self-degradation of the hydrogel were achieved via the Michael addition and subsequent hydrolysis of the addition product. In vivo experiments further showed that the hydrogel adhesive was efficiently applied for skin wound repair.


Asunto(s)
Hidrogeles , Cicatrización de Heridas , Adhesivos , Coprinus , Piel
5.
Adv Gerontol ; 34(1): 33-38, 2021.
Artículo en Ruso | MEDLINE | ID: mdl-33993659

RESUMEN

Adhesive small bowel obstruction is a common pathology with a tendency to increase characterized by a complex pathogenetic course with a high percentage of complications and deaths. Among the forms of intestinal obstruction caused by mechanical obstacles acute small bowel obstruction ranges from 64,3 to 80% with a mortality rate of 5,1 to 8,4% in the structure of urgent diseases. The complexity of early diagnosis along with an erased clinical picture severe course against a burdened background as well as age - in elderly and senile people leads to the search for new optimized treatment and diagnostic protocols. The purpose of this study was to study the nature of the course of adhesive small bowel obstruction in elderly and senile people to establish the information content of various diagnostic methods to determine the indications for the choice of the optimal period and method of treatment. A comparative analysis of 191 patients aged 60 to 90 years and older who received treatment in the surgical departments of St. Elizabeth Hospital (St. Petersburg) in the period from 2016-2019 was carried out. All patients were divided into 2 groups: the main group consisted of 106 patients (2018-2019) the comparison group included 85 patients (2016-2017). All patients of the main group used an improved diagnostic and treatment algorithm with the use of an original point-assessment scale which made it possible to optimize diagnostics and improve treatment results. Patients in the comparison group were examined in accordance with standard protocols and surgical treatment was carried out exclusively by traditional methods. The use of the proposed therapeutic and diagnostic algorithm made it possible to increase the probability of conservative resolution of acute adhesive small bowel obstruction from 20% (17) to 33% (35) and to reduce the incidence of postoperative complications from 60,2% (41) to 25,3% (18), p<0,01, and the mortality rate from 23,5% (16) to 7% (5), p<0,05.


Asunto(s)
Adhesivos , Obstrucción Intestinal , Anciano , Anciano de 80 o más Años , Humanos , Intestino Delgado , Complicaciones Posoperatorias , Adherencias Tisulares/complicaciones , Adherencias Tisulares/diagnóstico , Adherencias Tisulares/epidemiología , Resultado del Tratamiento
6.
Sensors (Basel) ; 21(9)2021 Apr 30.
Artículo en Inglés | MEDLINE | ID: mdl-33946269

RESUMEN

There are few reports on head-to-head comparisons of electrocardiogram (ECG) monitoring between adhesive single-lead and Holter devices for arrhythmias other than atrial fibrillation (AF). This study aimed to compare 24 h ECG monitoring between the two devices in patients with general arrhythmia. Twenty-nine non-AF patients with a workup of pre-diagnosed arrhythmias or suspicious arrhythmic episodes were evaluated. Each participant wore both devices simultaneously, and the cardiac rhythm was monitored for 24 h. Selective ECG parameters were compared between the two devices. Two cardiologists independently compared the diagnoses of each device. The two most frequent monitoring indications were workup of premature atrial contractions (41.4%) and suspicious arrhythmia-related symptoms (37.9%). The single-lead device had a higher noise burden than the Holter device (0.04 ± 0.05% vs. 0.01 ± 0.01%, p = 0.024). The number of total QRS complexes, ventricular ectopic beats, and supraventricular ectopic beats showed an excellent degree of agreement between the two devices (intraclass correlation coefficients = 0.991, 1.000, and 0.987, respectively). In addition, the minimum/average/maximum heart rates showed an excellent degree of agreement. The two cardiologists made coherent diagnoses for all 29 participants using both monitoring methods. In conclusion, the single-lead adhesive device could be an acceptable alternative for ambulatory ECG monitoring in patients with general arrhythmia.


Asunto(s)
Fibrilación Atrial , Electrocardiografía Ambulatoria , Adhesivos , Fibrilación Atrial/diagnóstico , Electrocardiografía , Humanos , Monitoreo Ambulatorio
7.
Khirurgiia (Mosk) ; (6): 45-53, 2021.
Artículo en Ruso | MEDLINE | ID: mdl-34029035

RESUMEN

OBJECTIVE: To improve the outcomes of therapy of acute adhesive small bowel obstruction via development of a comprehensive management including CT, deep endoscopy-assisted nasointestinal drainage of small bowel with injection of a water-soluble contrast. MATERIAL AND METHODS: There were 128 patients with acute adhesive small bowel obstruction for the period from 2015 to 2018. The study included 2 groups of patients depending on therapeutic approach and duration of treatment. In the first group, conventional approach for acute adhesive small bowel obstruction was applied. Upon admission, all patients with confirmed acute adhesive small bowel obstruction underwent gastric intubation for decompression of the upper gastrointestinal tract. Barium sulfate injection followed by X-ray examination was performed to assess an effectiveness of therapy. In the second group, computed tomography was performed in addition to X-ray examination and ultrasound. Moreover, conservative treatment included deep endoscopy-assisted nasointestinal drainage and subsequent administration of a water-soluble contrast in addition to traditional approaches. RESULTS: Therapy was effective in 99 (71.2%) patients; 39 (28.8%) ones required surgery. Deep endoscopy-assisted nasointestinal drainage with injection of a water-soluble contrast was effective in 45 (78.9%) patients. Overall mortality in traditional approach was 1.4%, postoperative mortality - 3.7%. There were no lethal outcomes in case of a new approach. CONCLUSION: Deep endoscopy-assisted nasointestinal drainage with injection of a water-soluble contrast is the most effective therapeutic method for acute adhesive small bowel obstruction (78.9%). These findings can significantly improve treatment outcomes in these patients.


Asunto(s)
Tratamiento Conservador , Obstrucción Intestinal , Adhesivos , Medios de Contraste , Diatrizoato de Meglumina , Humanos , Obstrucción Intestinal/patología , Obstrucción Intestinal/terapia , Intestino Delgado/patología , Adherencias Tisulares/complicaciones , Adherencias Tisulares/patología , Adherencias Tisulares/terapia
8.
AAPS PharmSciTech ; 22(4): 150, 2021 May 10.
Artículo en Inglés | MEDLINE | ID: mdl-33973096

RESUMEN

Suspension-based matrix transdermal delivery systems (TDSs) are specialized systems that maintain a continuous driving force for drug delivery over prolonged wear. The pressure-sensitive adhesive (PSA) is the most critical constituent of such systems. Our study aimed to determine the effect of different mixing methods on the performance of silicone PSA-based suspension TDSs. Lidocaine suspension TDSs were prepared using conventional slow rotary mixing, high-speed homogenization, bead-mill homogenization, vortex shaking, and by an unguator. Resultant TDSs were tested for tack, shear, and peel properties and correlated to coat weight, content uniformity, microstructure, and in vitro permeation across dermatomed human skin. Every mixing method tested caused a significant reduction in peel. However, bead-mill homogenization resulted in significant loss of all adhesive properties tested, while unguator-mixed TDSs retained most properties. Good linear correlation (R2 = 1.000) between the shear properties of the TDSs with the average cumulative amount of lidocaine permeated after 24 h was observed, with no significant difference between percutaneous delivery from slow rotary-mixed systems (1334 ± 59.21 µg/cm2) and unguator-mixed systems (1147 ± 108.3 µg/cm2). However, significantly lower delivery from bead-mill homogenized systems (821.1 ± 28.00 µg/cm2) was noted. While many factors affect TDS performance, careful consideration must also be given to the processing parameters during development as they have been shown to affect the resultant system's therapeutic efficacy. Extensive mixing with bead-mill homogenization demonstrated crystallization of drug, loss in adhesive properties, coat weight, and film thickness, with reduced transdermal delivery of lidocaine from the prepared system.


Asunto(s)
Adhesivos/administración & dosificación , Adhesivos/síntesis química , Sistemas de Liberación de Medicamentos/métodos , Absorción Cutánea/efectos de los fármacos , Parche Transdérmico , Adhesivos/farmacocinética , Administración Cutánea , Anestésicos Locales/administración & dosificación , Anestésicos Locales/síntesis química , Anestésicos Locales/farmacocinética , Humanos , Lidocaína/administración & dosificación , Lidocaína/síntesis química , Lidocaína/farmacocinética , Aceite Mineral/administración & dosificación , Aceite Mineral/síntesis química , Aceite Mineral/farmacocinética , Técnicas de Cultivo de Órganos , Siliconas/metabolismo , Siliconas/farmacología , Absorción Cutánea/fisiología , Suspensiones
9.
J Mech Behav Biomed Mater ; 119: 104498, 2021 07.
Artículo en Inglés | MEDLINE | ID: mdl-33839538

RESUMEN

OBJECTIVE: In this study, we incorporated hybrid nanoparticles (poly (acrylic acid)-grafted nanoclay/nanosilica, respectively, with platelet and spherical morphologies, abbreviated as PAA-g-NC-Sil) in different concentrations (0, 0.2, 0.5, 1, 2 and 5 wt%) to an experimental dentin bonding system and investigated the physical properties of the filled adhesive and its shear bond strength (µ-SBS) to dentin. We subsequently compared the properties of the adhesives containing PAA-g-NC-Sil with previously studied adhesives containing poly (methacrylic acid)-g-nanoclay (PMA-g-NC) (Solhi et al., 2012a), poly (acrylic acid)-g-nanoclay (PAA-g-NC) (Solhi et al., 2012b), and the hybrid poly (methacrylic acid)-grafted-nanoclay-nanosilica (PMA-g-NC-Sil) (Solhi et al., 2020). MATERIALS AND METHODS: In a set of previous publications and the present paper, we grafted poly (acrylic acid) (PAA) or poly (methacrylic acid) (PMA) onto the surface of pristine Na-MMT nanoclay (Cloisite® Na+) through free radical polymerization of monomer in an aqueous media in the presence or absence of nanosilica particles. We characterized the resulting modified nanoparticles (PMA-g-NC, PAA-g-NC, PMA-g-NC-Sil and PAA-g-NC-Sil) using GPC, FTIR, TGA, and XRD. We then incorporated the modified particles as functionalized fillers to experimental dentin adhesives in different concentrations and studied the stability of modified fillers dispersion by separation analysis. We also studied the properties of the photo-cured adhesive matrices using FTIR, TEM, SEM, EDXA, and XRD. We examined the shear bond strength of the adhesives (containing different contents of each modified filler, separately) to human premolar teeth. The results were analysed and compared statistically. RESULTS: The results confirmed that the polymers have been grafted onto the surface of nanoclay. An exfoliated structure for the nanoclay platelets in the photo-cured adhesive containing PAA-g-NC-Sil was observed. Addition of 0.5 wt% of PAA-g-NC-Sil to the experimental adhesive increased the shear bond strength and the dispersion stability in comparison to unfilled adhesive. The same trend was also observed for adhesives containing PMA-g-NC, PAA-g-NC, and PMA-g-NC-Sil. The adhesive containing PAA-g-NC-Sil showed the best dispersion stability and subsequently the highest shear bond strength in the optimal concentration among adhesives containing the four available fillers (PMA-g-NC, PAA-g-NC, PMA-g-NC-Sil and PAA-g-NC-Sil). SIGNIFICANCE: Addition of poly (acrylic acid) modified nanoparticles to the experimental dentin adhesives resulted in higher shear bond strength due to the potential interactions between the carboxylic acid functional groups on the surface of the modified particles and the dentin structure. Between the poly (acrylic acid) and poly (methacrylic acid), the former acid with higher PKa performed better. Addition of the spherical nanosilica particles to the adhesives containing platelet nanoclay helped to better exfoliate the platelets resulting in improved µ-SBS and dispersion stability.


Asunto(s)
Recubrimiento Dental Adhesivo , Nanopartículas , Adhesivos , Cementos Dentales , Dentina , Recubrimientos Dentinarios , Humanos , Ensayo de Materiales , Polimerizacion , Cementos de Resina , Resistencia al Corte
10.
Mater Sci Eng C Mater Biol Appl ; 123: 111978, 2021 Apr.
Artículo en Inglés | MEDLINE | ID: mdl-33812606

RESUMEN

Herein, we fabricated novel self-healing, in situ injectable, biodegradable, and non-toxic hydrogels anti-adhesion barrier materials composed of N, O-carboxymethyl chitosan (N,O-CS) and oxidized dextran (ODA) without requiring any chemical cross-linking agent or external stimuli triggers for the prevention and treatment of post-operative peritoneal adhesions. The N,O-CS/ODA hydrogels have a good suitable gelation time, good cytocompatibility and hemocompatibility, good antibacterial activity, excellent biodegradable and biocompatible, and can effectively inhibit the adhesion of fibroblasts to the wound, thereby suggesting that N,O-CS/ODA hydrogels are suitable for preventing post-operative adhesion. Meanwhile, a rat injury sidewall-cecum abrasion model is developed to investigate the efficacy of these hydrogels in achieving post-operative anti-adhesion. A significant reduction of peritoneal adhesions (10% rat with lower score adhesion) is observed in the N,O-CS/ODA-hydrogel-treated group compared with the commercial hydrogel and control groups. These results demonstrated that N,O-CS/ODA hydrogel could effectively prevent post-operative peritoneal adhesion without side effects. Therefore, the N,O-CS/ODA hydrogels with multi-functional properties exhibit great potential for the prevention and treatment of postoperative adhesion.


Asunto(s)
Quitosano , Hidrogeles , Adhesivos , Animales , Antibacterianos/farmacología , Vendajes , Quitosano/farmacología , Hemostasis , Hidrogeles/farmacología , Ratas , Ratas Sprague-Dawley
11.
Molecules ; 26(9)2021 Apr 26.
Artículo en Inglés | MEDLINE | ID: mdl-33926124

RESUMEN

Improving the environmental performance of resins in wood treatment by using renewable chemicals has been a topic of interest for a long time. At the same time, lignin, the second most abundant biomass on earth, is produced in large scale as a side product and mainly used energetically. The use of lignin in wood adhesives or for wood modification has received a lot of scientific attention. Despite this, there are only few lignin-derived wood products commercially available. This review provides a summary of the research on lignin application in wood adhesives, as well as for wood modification. The research on the use of uncleaved lignin and of cleavage products of lignin is reviewed. Finally, the current state of the art of commercialization of lignin-derived wood products is presented.


Asunto(s)
Adhesivos/química , Lignina/química , Madera/química , Biomasa , Materiales de Construcción , Resinas Epoxi , Hidrólisis , Fitoquímicos/química
12.
Nat Commun ; 12(1): 2407, 2021 04 23.
Artículo en Inglés | MEDLINE | ID: mdl-33893308

RESUMEN

Many features of extracellular matrices, e.g., self-healing, adhesiveness, viscoelasticity, and conductivity, are associated with the intricate networks composed of many different covalent and non-covalent chemical bonds. Whereas a reductionism approach would have the limitation to fully recapitulate various biological properties with simple chemical structures, mimicking such sophisticated networks by incorporating many different functional groups in a macromolecular system is synthetically challenging. Herein, we propose a strategy of convergent synthesis of complex polymer networks to produce biomimetic electroconductive liquid metal hydrogels. Four precursors could be individually synthesized in one to two reaction steps and characterized, then assembled to form hydrogel adhesives. The convergent synthesis allows us to combine materials of different natures to generate matrices with high adhesive strength, enhanced electroconductivity, good cytocompatibility in vitro and high biocompatibility in vivo. The reversible networks exhibit self-healing and shear-thinning properties, thus allowing for 3D printing and minimally invasive injection for in vivo experiments.


Asunto(s)
Adhesivos/química , Conductividad Eléctrica , Hidrogeles/química , Metales/química , Adhesivos/síntesis química , Adhesivos/farmacología , Animales , Antibacterianos/síntesis química , Antibacterianos/química , Antibacterianos/farmacología , Bacillus subtilis/efectos de los fármacos , Materiales Biocompatibles/síntesis química , Materiales Biocompatibles/química , Materiales Biocompatibles/farmacología , Línea Celular , Proliferación Celular/efectos de los fármacos , Escherichia coli/efectos de los fármacos , Hidrogeles/síntesis química , Hidrogeles/farmacología , Ratones , Microscopía Electrónica , Mioblastos/citología , Mioblastos/efectos de los fármacos , Polímeros/síntesis química , Polímeros/química , Polímeros/farmacología
13.
J Mech Behav Biomed Mater ; 119: 104529, 2021 07.
Artículo en Inglés | MEDLINE | ID: mdl-33910131

RESUMEN

To evaluate the effect of three adhesive systems applied under electric current on microtensile bond strength (µTBS) and degree of conversion (DC). Molar teeth were restored with the aid of three adhesive systems (Adper Single Bond 2-SB2; Clearfil SE Bond-CSE; and Single Bond Universal-SBU) under different electric current intensities (0 µA; 25 µA; and 50 µA). Composite resin blocks were built up in increments (2 mm) and sectioned into 1 × 1 mm beams. The µTBS was tested after 24 h and 1 y distilled water storages. Samples (n = 10) from 24 h to 1 y storages were immersed in a 50% ammoniacal silver nitrate solution and submitted to scanning electron microscopy. The silver nitrate in the hybrid layer was quantified (ImageJ software). The adhesive systems' dentinal infiltration was analyzed using confocal laser scanning microscopy. Fourier transform near infrared spectroscopy was used to measure the DC. The µTBS data were submitted to two-way ANOVA (time vs. electric current) and Bonferroni's test (α = 0.05). Quantitative nanoleakage data were submitted to two-way ANOVA (electric current vs. adhesive) and Bonferroni's test (α = 0.05). DC data were submitted to one-way ANOVA and Tukey's test (α = 0.05) for each adhesive system. The electric current statistically increased the µTBS for SB2 and CSE in 24 h storage, as well as for SB2, CSE and SBU in 1 y storage. No significant difference was observed between storage time for CSE and SBU. When compared to the control, electric currents (25 µA and 50 µA) showed significantly higher DC mean values for SB2 and SBU, and had no effect on CSE. The electric currents (25 µA and 50 µA) reduced the adhesive system's nanoleakage after 1-year storage, and improved the infiltration of SB2 and CSE. Both electric current intensities improved dentinal interface stability.


Asunto(s)
Recubrimiento Dental Adhesivo , Recubrimientos Dentinarios , Adhesivos , Resinas Compuestas , Dentina , Ensayo de Materiales , Microscopía Electrónica de Rastreo , Cementos de Resina , Resistencia a la Tracción
14.
Int J Mol Sci ; 22(7)2021 Mar 25.
Artículo en Inglés | MEDLINE | ID: mdl-33806079

RESUMEN

We focus on the stalked goose barnacle L. anatifera adhesive system, an opportunistic less selective species for the substrate, found attached to a variety of floating objects at seas. Adhesion is an adaptative character in barnacles, ensuring adequate positioning in the habitat for feeding and reproduction. The protein composition of the cement multicomplex and adhesive gland was quantitatively studied using shotgun proteomic analysis. Overall, 11,795 peptide sequences were identified in the gland and 2206 in the cement, clustered in 1689 and 217 proteinGroups, respectively. Cement specific adhesive proteins (CPs), proteases, protease inhibitors, cuticular and structural proteins, chemical cues, and many unannotated proteins were found, among others. In the cement, CPs were the most abundant (80.5%), being the bulk proteins CP100k and -52k the most expressed of all, and CP43k-like the most expressed interfacial protein. Unannotated proteins comprised 4.7% of the cement proteome, ranking several of them among the most highly expressed. Eight of these proteins showed similar physicochemical properties and amino acid composition to known CPs and classified through Principal Components Analysis (PCA) as new CPs. The importance of PCA on the identification of unannotated non-conserved adhesive proteins, whose selective pressure is on their relative amino acid abundance, was demonstrated.


Asunto(s)
Adhesivos , Péptidos/metabolismo , Proteogenómica , Proteoma , Thoracica/metabolismo , Animales , Proteínas de Artrópodos/metabolismo , Análisis por Conglomerados , Ecosistema , Peso Molecular , Análisis de Componente Principal , Proteómica/métodos
15.
Acta Biomater ; 127: 242-251, 2021 06.
Artículo en Inglés | MEDLINE | ID: mdl-33812075

RESUMEN

Adhesion properties, which can vary with multiple factors, of silicone hydrogel contact lenses are important to their performance and comfort in the eye. In this study, we developed and used a simple, representative testing system and method to study the adhesive interactions of different silicone contact lenses (balafilcon A and senofilcon A) on polished titanium alloy and porcine whole eye cornea under dehydrating conditions. Adhesive interactions for senofilcon A varied by hydration state for both corneal and titanium adhesion, starting low, rising to a maximum and falling with dehydration time and dehydration state. Balafilcon A showed a rise and fall against titanium, but retained a relatively constant adhesive interaction with corneal tissue over dehydration time. Senofilcon A reached the highest adhesion forces (400 mN) within 5 to 10 min of testing against cornea, then dropped with time after that. Johnson-Kendall-Roberts (JKR) theory was applied to determine the surface energy of the lenses, and work of adhesion (WOA) was also determined for both lenses. Similar trends as observed with the force-hydration curves were seen with surface energy and work of adhesion as well (peak surface energy of 8 N/m and work of adhesion of 80 µJ for senofilcon A). Video imaging of the adhesive interactions showed significant corneal deformation taking place during testing, and post-test analysis shows damage to the corneal tissue. This method could be used to assess pre-clinical performance of long-lasting contact lenses and the role of hydration state. STATEMENT OF SIGNIFICANCE: Adhesion properties of contact lenses play significant roles in their performance and comfort in the eye. Adhesion is influenced by polymer chemistry, counterface materials and hydration state of the contact lenses. However, no test method has been developed to directly study the adhesion properties between contact lenses and corneal tissue during the dehydration process. Our work aims to fill this gap by developing testing and analysis methods for evaluating the adhesive interactions in vitro between contact lenses of different chemistries and properties and different counter surfaces under dehydrating conditions over time. Our study shows that adhesive interactions of contact lenses are highly dependent on polymer type, surface treatment, counterface material and hydration state.


Asunto(s)
Lentes de Contacto Hidrofílicos , Siliconas , Adhesivos , Animales , Córnea , Hidrogel de Polietilenoglicol-Dimetacrilato , Hidrogeles , Porcinos
16.
Biomaterials ; 272: 120774, 2021 05.
Artículo en Inglés | MEDLINE | ID: mdl-33798963

RESUMEN

Damaged vascular structures after critical diseases are difficult to completely restore to their original conditions without specific treatments. Thus, therapeutic angiogenesis has been spotlighted as an attractive strategy. However, effective strategies for mimicking angiogenic processes in the body have not yet been developed. In the present work, we developed a bioengineered mussel adhesive protein (MAP)-based novel therapeutic angiogenesis platform capable of spatiotemporally releasing angiogenic growth factors to target disease sites with high viscosity and strong adhesiveness in a mucus-containing environment with curvature. Polycationic MAP formed complex coacervate liquid microdroplets with polyanionic hyaluronic acid and subsequently gelated into microparticles. Platelet-derived growth factor (PDGF), which is a late-phase angiogenic factor, was efficiently encapsulated during the process of coacervate microparticle formation. These PDGF-loaded microparticles were blended with vascular endothelial growth factor (VEGF), which is the initial-phase angiogenic factor, in MAP-based pregel solution and finally crosslinked in situ into a hydrogel at the desired site. The microparticle-based angiogenic-molecule spatiotemporal sequential (MASS) release platform showed good adhesion and underwater durability, and its elasticity was close to that of target tissue. Using two in vivo critical models, i.e., full-thickness excisional wound and myocardial infarction models, the MASS release platform was evaluated for its in vivo feasibility as an angiogenesis-inducing platform and demonstrated effective angiogenesis as well as functional regenerative efficacy. Based on these superior physicochemical characteristics, the developed MASS release platform could be successfully applied in many biomedical practices as a waterproof bioadhesive with the capability for the spatiotemporal delivery of angiogenic molecules in the treatment of ischemic diseases.


Asunto(s)
Inductores de la Angiogénesis , Medicina Regenerativa , Adhesivos , Neovascularización Fisiológica , Factor de Crecimiento Derivado de Plaquetas , Factor A de Crecimiento Endotelial Vascular
17.
J Dent ; 108: 103638, 2021 05.
Artículo en Inglés | MEDLINE | ID: mdl-33727079

RESUMEN

OBJECTIVES: This systematic review aims to investigate the efficacy of denture adhesives (DAs) for complete dentures (CDs), and to provide clinical recommendations for prosthodontists and general practitioners. DATA/SOURCES: Electronic databases (Medline, Embase, CENTRAL) and gray literatures were searched (up to March 2020) for relevant randomized and non-randomized controlled clinical trials (RCTs and CCTs) evaluating the efficacy of DAs when applied to CDs. Primary outcomes were objectively assessed variables directly related to mastication (denture retention, maximum bite force and masticatory efficiency). Secondary outcomes included other objectively assessed variables and patient-reported outcomes. STUDY SELECTION: Of the 1729 records identified, 39 studies (43 articles) were included in the analysis. Among them, 23 were RCTs and 16 were CCTs, with two multicenter clinical trials (1 RCT and 1 CCT). Meta-analysis results indicated that DAs provided significantly higher retention (SMD 1.34, 95 % CI: 0.89-1.79, P < 0.001) for CDs. Bite force (SMD 0.98, 95 % CI: 0.50-1.47, P < 0.001) and masticatory performance (SMD 0.72, 95 % CI: 0.23-1.22, P = 0.004) of the CD wearers were also improved after using DAs, but the effect size was relatively smaller. CONCLUSION: Based on the results of this systematic review, it is concluded that DAs can improve denture retention, bite force and masticatory performance of CD wearers. CLINICAL SIGNIFICANCE: This study investigated the effects of all types of DAs for CDs in terms of their effects on denture retention, masticatory performance, oral health-related quality of life and oral microorganisms for CD wearers.


Asunto(s)
Dentadura Completa , Calidad de Vida , Adhesivos , Fuerza de la Mordida , Retención de Dentadura , Humanos , Masticación , Estudios Multicéntricos como Asunto
18.
AAPS PharmSciTech ; 22(3): 87, 2021 Mar 04.
Artículo en Inglés | MEDLINE | ID: mdl-33665761

RESUMEN

The commitment of the existent study was to develop a mucoadhesive in situ gel systems of vitamin B12 for the management of dry eye disease. The gels were prepared using pluronic F-127 and either of chitosan, carbapol 971P, sodium alginate, or hydroxy propyl methyl cellulose. Drug-excipients compatibility was investigated by means of differential scanning calorimetry and Fourier transform infrared spectroscopy. The gels were characterized for pH, clarity, gelling capacity, viscosity, and adhesion. In vitro release of vitamin B12 from the selected gels was investigated. In vivo effectiveness of the selected gel was determined in rabbit models using Schirmer's and fluorescein tests. The compatibility studies revealed the possibility of incidence of drug/polymer interaction in some formulations. F2-containing pluronic F127 and hydroxypropyl methyl cellulose showed the most appropriate physical characterization and in vitro release profile. The prepared gels showed prolonged drug release with drug release mechanism of combined diffusion and erosion. The in vivo study revealed good effectiveness of the prepared mucoadhesive in situ gel system of vitamin B12 in the treatment of dry eye disease that was comparable to that of the marketed drops.


Asunto(s)
Síndromes de Ojo Seco/tratamiento farmacológico , Vitamina B 12/uso terapéutico , Vitaminas/uso terapéutico , Adhesivos , Animales , Composición de Medicamentos , Sistemas de Liberación de Medicamentos , Liberación de Fármacos , Excipientes , Femenino , Geles , Derivados de la Hipromelosa , Masculino , Membrana Mucosa , Poloxámero , Conejos , Viscosidad , Vitamina B 12/administración & dosificación , Vitaminas/administración & dosificación
19.
Carbohydr Polym ; 261: 117878, 2021 Jun 01.
Artículo en Inglés | MEDLINE | ID: mdl-33766365

RESUMEN

Hydrogels have gained great attentions as wound dressing. Binding to the tissue and preventing wound infection were the basic requirements for an "ideal dressing". We employed l-DOPA and ε-Poly-l-lysine to modify thermo-sensitive hydroxybutyl chitosan (HBC) to obtain (l-DOPA) - (ε-Poly-l-lysine)-HBC hydrogels (eLHBC). The eLHBC exhibited an almost 1.5 fold (P < 0.01) increase in wet adhesion strength compared to HBC. Upon the introduction of ε-Poly-l-lysine, eLHBC presented inherent antimicrobial property and prevented wound infection and inflammation response. Bone marrow mesenchymal stem cells (BMSCs) encapsulated in the eLHBC (BMSCs ⊂ eLHBC) could secret cytokins and growth factors via paracrine and promote the migration of fibroblast cells. BMSCs ⊂ eLHBC enhanced the complete skin-thickness wound healing via promoting collagen deposition and inhibiting infection and inflammation in vivo with wound closure rate being above 99 % after 15 days. The bioinspired, tissue-adhesive eLHBC could serve as advanced wound dressings for facilitating tissue repair and regeneration.


Asunto(s)
Adhesivos , Vendas Hidrocoloidales , Quitosano/análogos & derivados , Células Madre Mesenquimatosas/efectos de los fármacos , Andamios del Tejido/química , Adhesivos/síntesis química , Adhesivos/química , Adhesivos/farmacología , Animales , Antibacterianos/síntesis química , Antibacterianos/química , Antibacterianos/farmacología , Bioingeniería/métodos , Materiales Biomiméticos/síntesis química , Materiales Biomiméticos/química , Materiales Biomiméticos/farmacología , Bivalvos/química , Bivalvos/metabolismo , Adhesión Celular/efectos de los fármacos , Técnicas de Cultivo de Célula/instrumentación , Técnicas de Cultivo de Célula/métodos , Células Cultivadas , Quitosano/síntesis química , Quitosano/química , Quitosano/farmacología , Matriz Extracelular/química , Matriz Extracelular/efectos de los fármacos , Hemólisis/efectos de los fármacos , Hidrogeles/síntesis química , Hidrogeles/química , Hidrogeles/farmacología , Masculino , Ensayo de Materiales , Células Madre Mesenquimatosas/citología , Células Madre Mesenquimatosas/fisiología , Ratones , Pruebas de Sensibilidad Microbiana , Péptidos/síntesis química , Péptidos/química , Péptidos/farmacología , Conejos , Ratas , Ratas Sprague-Dawley , Temperatura , Cicatrización de Heridas/efectos de los fármacos
20.
BMC Surg ; 21(1): 158, 2021 Mar 22.
Artículo en Inglés | MEDLINE | ID: mdl-33752652

RESUMEN

BACKGROUND: Laparoscopic paraesophageal hernia repair is associated with higher recurrence rate. Mesh is used to reduce the recurrence rate. This retrospective study is to review our experience of biological mesh fixed with suture and medical glue in hiatal hernias repairs. METHODS: A retrospective chart review was conducted for a consecutive series of patients undergoing laparoscopic hiatal herniorrhaphy between January 2018 and January 2019. After hiatus closure, a piece of biological prosthesis was fixed with medical glue and suture for reinforcement of the crural closure. Clinical outcomes were reviewed, and data were collected regarding operative details, complications, symptoms, and follow-up imaging. Radiological evidence of any size of hiatal hernia was considered to indicate a recurrence. RESULTS: Thirty-six patients underwent surgery uneventfully without any serious complication. There was no mortality. The follow-up was, on average, 18.4 months, and there was no symptomatic recurrence. There was one anatomical recurrence without any related presentation. The method of mesh fixation with medical glue and suture took 12 min on average, and the handling was fairly easy. CONCLUSIONS: Biological mesh fixed with suture and medical glue was safe and effective for repairing large hiatal hernias. Of course, a longer follow-up is still needed for determining long-term outcomes.


Asunto(s)
Hernia Hiatal , Herniorrafia , Laparoscopía , Adhesivos , Anciano , Anciano de 80 o más Años , Femenino , Hernia Hiatal/cirugía , Herniorrafia/métodos , Humanos , Masculino , Persona de Mediana Edad , Recurrencia , Estudios Retrospectivos , Mallas Quirúrgicas , Suturas , Resultado del Tratamiento
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