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1.
An. psicol ; 39(1): 20-27, Ene-Abr. 2023. tab
Artículo en Inglés | IBECS | ID: ibc-213835

RESUMEN

Se realizó un ensayo clínico aleatorio con dos grupos de tratamiento: uno que recibió terapia cognitivo-conductual (TCC) y otro con la inclusión de técnicas emocionales (TCCE), ambos de 20 sesiones. La muestra consistió en 237 pacientes, todos ellos con diagnóstico principal de trastornos de ansiedad, y todos remitidos por sus médicos de cabecera. Hubo mejoras significativas en la sintomatología (rasgo de ansiedad, depresión, sintomatología clínica), pero la única diferencia significativa encontrada en la comparación intergrupal fue para la variable "satisfacción vital subjetiva" (p= .017), que fuemayor en el grupo de TCCE. Este grupo también mostró una mayor adherencia al programa de tratamiento (p= .019). Esto refuerza la conveniencia de incluir el tratamiento de terapia de grupo con componentes emocionales en los entornos de atención primaria, destacando la importancia de hacer hincapié en la autoestima.(AU)


A randomized clinical trial was carried out with two treatment groups: one receiving cognitive-behavioral therapy (CBT) and the other with the inclusion of emotional techniques (CEBT), both lasting 20 sessions. The sample consisted of 237 patients, all of them with principal diagnoses of anxiety disorders, and all referred by their general practitioners. There were significant improvements in symptomatology (anxiety trait, depression, clinical symptomatology), but the only significant difference found in the intergroup comparison was for the variable “subjective life satisfaction” (p = .017), which was greater in the CEBT group. This group also displayed better adherence to the treatment program (p = .019). This reinforces the case for including group therapy treatment with emotional components in primary care settings, highlighting the importance of emphasizing self-esteem.(AU)


Asunto(s)
Humanos , Masculino , Femenino , Ansiedad , Psicoterapia de Grupo , Terapia Cognitivo-Conductual , Emociones , Satisfacción Personal , Salud Pública , Autoimagen , Psicología , Psicología Clínica , Psicología Social
2.
Eur. j. psychiatry ; 37(1): 15-23, enero 2023.
Artículo en Inglés | IBECS | ID: ibc-213937

RESUMEN

Background and objectives: Despite the growing pieces of evidence on the relationship between the altered expression level of miRNAs and major depressive disorder (MDD), few studies have focused on the relationship between the altered expression of miRNAs and the severity of depressive symptoms. This study aimed to investigate the relationship between the expression level of miRNA-4485 and the severity of depressive symptoms in major depressive disorder (MDD) patients.MethodsEighty MDD patients without antidepressants and 45 healthy controls were placed and tested for the expression level of miRNA-4485 using quantitative RT‒PCR. At the same time, the Hamilton Depression Scale (HAMD) was used to assess depression symptoms for MDD patients. Twenty-nine out of 80 MDD patients were selected for miRNA expression level testing and symptomatology assessments before and after three weeks of treatment.ResultsThe expression level of miRNA-4485 in the MDD group was significantly overexpressed compared to that in healthy controls (P < 0.05), and the expression level of miRNA-4485 in the higher HAMD group was also much higher than that in the lower HAMD group and healthy controls (P < 0.05). The expression level of miRNA-4485 in MDD patients was negatively correlated with HAMD total score, anxiety/somatization, and bodyweight factor score (P < 0.05), accounting for 9.4%, 12.4% and 5.7%, respectively. MiRNA-4485 significantly predicted MDD and the severity of depressive symptoms (P < 0.05). Compared with that before treatment, the expression level of miRNA-4485 was significantly downregulated after treatment, while the patient's depressive symptoms were improved (p < 0.05). The improvement in depressive symptoms was positively correlated with the downregulation of miRNA-4485, which could significantly predict the effects of antidepressant treatment on MDD (P < 0.05). (AU)


Asunto(s)
Humanos , Trastorno Depresivo Mayor , MicroARNs , Depresión , Ansiedad , Terapéutica
3.
J. optom. (Internet) ; 16(1)January - March 2023. ilus
Artículo en Inglés | IBECS | ID: ibc-CR-668

RESUMEN

Visual cues usually play a vital role in social interaction. As well as being the primary cue for identifying other people, visual cues also provide crucial non-verbal social information via both facial expressions and body language. One consequence of vision loss is the need to rely on non-visual cues during social interaction. Although verbal cues can carry a significant amount of information, this information is often not available to an untrained listener. Here, we review the current literature examining potential ways that the loss of social information due to vision loss might impact social functioning. A large number of studies suggest that low vision and blindness is a risk factor for anxiety and depression. This relationship has been attributed to multiple factors, including anxiety about disease progression, and impairments to quality of life that include difficulties reading, and a lack of access to work and social activities. However, our review suggests a potential additional contributing factor to reduced quality of life that has been hitherto overlooked: blindness may make it more difficult to effectively engage in social interactions, due to a loss of visual information. The current literature suggests it might be worth considering training in voice discrimination and/or recognition when carrying out rehabilitative training in late blind individuals. (AU)


Asunto(s)
Humanos , Ansiedad/psicología , Ceguera/psicología , Baja Visión , Calidad de Vida/psicología , Trastornos de la Visión/etiología , Relaciones Interpersonales
4.
Pharmacogenomics ; 24(1): 27-57, 2023 Jan.
Artículo en Inglés | MEDLINE | ID: mdl-36628952

RESUMEN

Anxiety and depression coexist with cognitive impairment in Alzheimer's disease along with other concomitant disorders (>60%), which require multipurpose treatments. Polypharmaceutical regimens cause drug-drug interactions and adverse drug reactions, potentially avoidable in number and severity with the implementation of pharmacogenetic procedures. The accumulation of defective variants (>30 genes per patient in more than 50% of cases) in pharmagenes (pathogenic, mechanistic, metabolic, transporter, pleiotropic) influences the therapeutic response to antidementia, antidepressant and anxiolytic drugs in polyvalent regimens. APOE, CYP1A2, CYP2C9, CYP2C19, CYP2D6, CYP2E1, CYP3A4, CYP3A5, CYP4F2, COMT, MAOB, CHAT, GSTP1, NAT2, SLC30A8, SLCO1B1, ADRA2A, ADRB2, BCHE, GABRA1, HMGCR, HTR2C, IFNL3, NBEA, UGT1A1, ABCB1, ABCC2, ABCG2, SLC6A2, SLC6A3, SLC6A4, MTHFR and OPRM1 variants affect anxiety and depression in Alzheimer's disease.


Asunto(s)
Enfermedad de Alzheimer , Arilamina N-Acetiltransferasa , Humanos , Enfermedad de Alzheimer/tratamiento farmacológico , Enfermedad de Alzheimer/genética , Farmacogenética/métodos , Depresión/tratamiento farmacológico , Depresión/genética , Citocromo P-450 CYP2D6/genética , Ansiedad/tratamiento farmacológico , Ansiedad/genética , Transportador 1 de Anión Orgánico Específico del Hígado , Proteínas Portadoras , Proteínas del Tejido Nervioso , Proteínas de Transporte de Serotonina en la Membrana Plasmática
5.
Radiol Technol ; 94(3): 180-196, 2023 01.
Artículo en Inglés | MEDLINE | ID: mdl-36631224

RESUMEN

PURPOSE: To review and synthesize the available evidence on the effectiveness of preparatory digital counseling for children undergoing diagnostic imaging and their parents in terms of patient-related and imaging outcomes. METHODS: Relevant studies were identified by searching databases and gray literature resources. References from full-text articles identified in the initial search were searched manually to identify additional relevant studies. The reviewed literature included studies on children and adolescents aged 3 to 21 years, their parents, or both, who participated in digital counseling interventions before medical imaging examinations. Literature selection and quality appraisal were conducted by 2 independent reviewers. Data were extracted using standardized tools and synthesized using the narrative synthesis approach. This review was reported according to Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. RESULTS: Five randomized controlled trials and quasi-experimental studies were included in this review. Digital counseling was provided via multiple approaches with interactive elements. Digital counseling was reported to be effective at reducing anxiety and increasing knowledge and satisfaction among children and their parents. It also appeared to reduce the need for general anesthesia and to improve the success of imaging procedures based on image quality and number of repeated images required. Digital counseling also appeared to increase children's confidence and help them remain still during the imaging process. DISCUSSION: The increased knowledge from digital counseling can strengthen senses of security and self-efficacy, which are important for successful medical imaging examinations, especially in children. The digital counseling applications used in the included studies are location-independent, and children and their parents can use them as often as they want, which might help ensure the provision of sufficient counseling before procedures. CONCLUSIONS: Digital counseling seems to be an effective method for preparing children for diagnostic imaging and a useful tool for facilitating successful medical imaging examinations of children. Because of the small number of original studies in this area, further research is needed to confirm the effectiveness of digital counseling in children's diagnostic imaging.


Asunto(s)
Ansiedad , Consejo , Adolescente , Niño , Humanos , Diagnóstico por Imagen
6.
Cell Rep Med ; 4(1): 100895, 2023 Jan 17.
Artículo en Inglés | MEDLINE | ID: mdl-36630953

RESUMEN

Controlled breathwork practices have emerged as potential tools for stress management and well-being. Here, we report a remote, randomized, controlled study (NCT05304000) of three different daily 5-min breathwork exercises compared with an equivalent period of mindfulness meditation over 1 month. The breathing conditions are (1) cyclic sighing, which emphasizes prolonged exhalations; (2) box breathing, which is equal duration of inhalations, breath retentions, and exhalations; and (3) cyclic hyperventilation with retention, with longer inhalations and shorter exhalations. The primary endpoints are improvement in mood and anxiety as well as reduced physiological arousal (respiratory rate, heart rate, and heart rate variability). Using a mixed-effects model, we show that breathwork, especially the exhale-focused cyclic sighing, produces greater improvement in mood (p < 0.05) and reduction in respiratory rate (p < 0.05) compared with mindfulness meditation. Daily 5-min cyclic sighing has promise as an effective stress management exercise.


Asunto(s)
Meditación , Humanos , Afecto , Ansiedad/terapia , Respiración , Nivel de Alerta
7.
Radiol Technol ; 94(3): 168-179, 2023 01.
Artículo en Inglés | MEDLINE | ID: mdl-36631221

RESUMEN

PURPOSE: To determine the relationships between mental health (depression and anxiety) and engaging in shift work, working weekend shifts, and taking call for radiologic technologists, and to identify coping strategies used to manage depression and anxiety. METHODS: Validated instruments were used to measure depression and anxiety levels among a sample of radiologic technologists who were members of Advanced Health Education Center. The participants also identified their primary work shift and their frequency of working weekends and taking call. RESULTS: There were 173 completed survey responses for this study. Most radiologic technologists in this study experienced mild symptoms of depression (62, 35.8%) and anxiety (57, 32.9%). Nearly half of the participants indicated that their depression and anxiety made it difficult for them to perform their jobs effectively, and about one-third of the participants believed those symptoms were intensified by shift work. A strong, positive relationship was identified between participants' total depression and anxiety scores (P < .001). There were no significant differences between shift work and total depression score (P = .06) or total anxiety score (P = .28). A significant association was found between the frequency of working weekend shifts and depression levels (P < .001) with a moderate effect size. Most of the participants identified support from family or friends, prayer and spiritual activities, and prescribed medication as common coping strategies. DISCUSSION: Findings revealed that the radiologic technologists in this study did not rely heavily on employer-based resources, such as employee assistance programs, to cope with their depression and anxiety symptoms. One speculation for underuse of these employer-based resources might be fear of being stigmatized by management or personal perceived stigma against asking for help. There is an opportunity for increased awareness of available mental health resources and acceptance of mental health management to erase the common, negative stigma associated with seeking out professional resources. CONCLUSION: Radiologic technologists in this study experienced depression and anxiety symptoms that affected their work performance and correlated with working weekend shifts; however, there was no significant relationship between shift work and depression or anxiety in this sample of radiologic technologists.


Asunto(s)
Salud Mental , Horario de Trabajo por Turnos , Humanos , Depresión/epidemiología , Ansiedad , Adaptación Psicológica , Encuestas y Cuestionarios
8.
BMJ ; 380: 153, 2023 01 19.
Artículo en Inglés | MEDLINE | ID: mdl-36657748

Asunto(s)
COVID-19 , Humanos , Ansiedad
9.
Transl Psychiatry ; 13(1): 16, 2023 Jan 19.
Artículo en Inglés | MEDLINE | ID: mdl-36658152

RESUMEN

Aerobic exercise effectively relieves anxiety disorders via modulating neurogenesis and neural activity. The molecular mechanism of exercise-mediated anxiolysis, however, remains incomplete. On a chronic restrain stress (CRS) model in adolescent mice, we showed that 14-day treadmill exercise profoundly maintained normal neural activity and axonal myelination in the medial prefrontal cortex (mPFC), in association with the prevention of anxiety-like behaviors. Further interrogation of molecular mechanisms revealed the activation of the mechanistic target of the rapamycin (mTOR) pathway within mPFC under exercise training. At the upstream of mTOR, exercise-mediated brain RNA methylation inhibited the expression of Fragile X mental retardation protein (FMRP) to activate the mTOR pathway. In summary, treadmill exercise modulates an FMRP-mTOR pathway to maintain cortical neural activity and axonal myelination, contributing to improved stress resilience. These results extended our understanding of the molecular substrate of exercise-mediated anxiolytic effect during adolescent period.


Asunto(s)
Proteína del Retraso Mental del Síndrome del Cromosoma X Frágil , Condicionamiento Físico Animal , Estrés Psicológico , Serina-Treonina Quinasas TOR , Animales , Ratones , Axones/metabolismo , Encéfalo/metabolismo , Proteína del Retraso Mental del Síndrome del Cromosoma X Frágil/genética , Serina-Treonina Quinasas TOR/metabolismo , Ansiedad
10.
Curr Oncol ; 30(1): 586-597, 2023 Jan 01.
Artículo en Inglés | MEDLINE | ID: mdl-36661695

RESUMEN

BACKGROUND: Significant changes in the accessibility and viability of health services have been observed during the COVID-19 period, particularly in vulnerable groups such as cancer patients. In this study, we described the impact of radical practice and perceived changes on cancer patients' mental well-being and investigated potential outcome descriptors. METHODS: Generalized anxiety disorder assessment (GAD-7), patient health (PHQ-9), and World Health Organization-five well-being index (WHO-5) questionnaires were used to assess anxiety, depression, and mental well-being. Information on participants, disease baseline information, and COVID-19-related questions were collected, and related explanatory variables were included for statistical analysis. RESULTS: The mean score values for anxiety, depression, and mental well-being were 4.7 ± 5.53, 4.9 ± 6.42, and 72.2 ± 18.53, respectively. GAD-7 and PHQ-9 scores were statistically associated (p < 0.001), while high values of GAD-7 and PHQ-9 questionnaires were related to low values of WHO-5 (p < 0.001).Using the GAD-7 scale, 16.2% of participants were classified as having mild anxiety (GAD-7 score: 5-9).Mild to more severe anxiety was significantly associated with a history of mental health conditions (p = 0.01, OR = 3.74, 95% CI [1.372-10.21]), and stage category (stage III/IV vs. I/II, p = 0.01, OR = 3.83, 95% CI [1.38-10.64]. From the participants, 36.2% were considered to have depression (PHQ-9 score ≥ 5). Depression was related with older patients (p = 0.05, OR = 1.63, 95% CI [1.16-2.3]), those with previous mental health conditions (p = 0.03, OR = 14.24, 95% CI [2.47-81.84]), those concerned about the COVID-19 impact on their cancer treatment (p = 0.027, OR = 0.19, 95% CI [0.045-0.82]) or those who felt that COVID-19 pandemic has affected mental health (p = 0.013, OR = 3.56, 95% CI [1.30-9.72]). Additionally, most participants (86.7%) had a good well-being score (WHO-5 score ≥ 50). Mental well-being seemed more reduced among stage I-III patients than stage IV patients (p = 0.014, OR = 0.12, 95% CI [0.023-0.65]). CONCLUSION: There is a necessity for comprehensive cancer care improvement. These patients' main concern related to cancer therapy, yet the group of patients who were mentally affected by the pandemic should be identified and supported.


Asunto(s)
COVID-19 , Neoplasias , Humanos , COVID-19/epidemiología , Depresión/etiología , Depresión/psicología , Pandemias , Ansiedad/epidemiología , Ansiedad/etiología , Ansiedad/psicología , Encuestas y Cuestionarios , Neoplasias/radioterapia
11.
PLoS One ; 18(1): e0280562, 2023.
Artículo en Inglés | MEDLINE | ID: mdl-36662687

RESUMEN

BACKGROUND: Young adults, particularly university students might be at greater risk of developing psychological distress, and exhibiting symptoms of anxiety and depression during the COVID-19 pandemic. The primary objective of this study was to explore and compare the determinants and predictors of mental health (anxiety and depression) during and after the COVID-19 lockdown among university students. METHODS: This was an observational, cross-sectional study with a sample size of 417 students. An online survey utilizing International Physical Activity Questionnaire-Short Form (IPAQ-SF), General Anxiety Disorder-7 (GAD-7) and Patient Health Questionnaire-9 (PHQ-9) was distributed to Universiti Tunku Abdul Rahman students via Google forms. RESULTS: During lockdown, family income [χ2 (1, n = 124) = 5.155, p = 0.023], and physical activity (PA) [χ2 (1, n = 134) = 6.366, p = 0.012] were associated with anxiety, while depression was associated with gender [χ2 (1, n = 75) = 4.655, p = 0.031]. After lockdown, family income was associated with both anxiety [χ2 (1, n = 111) = 8.089, p = 0.004], and depression [χ2 (1, n = 115) = 9.305, p = 0.002]. During lockdown, family income (OR = 1.60, p = 0.018), and PA (OR = 0.59, p = 0.011) were predictors for anxiety, while gender (OR = 0.65, p = 0.046) was a predictor for depression. After lockdown, family income was a predictor for both anxiety (OR = 1.67, p = 0.011), and depression (OR = 1.70, p = 0.009). CONCLUSION: Significant negative effects attributed to the COVID-19 lockdown, and certain factors predisposed to the worsening of mental health status in university students. Low family income, PA, and female gender were the major determinants and predictors linked to anxiety and depression.


Asunto(s)
COVID-19 , Adulto Joven , Humanos , Femenino , COVID-19/epidemiología , COVID-19/psicología , Salud Mental , Malasia/epidemiología , Pandemias , Universidades , SARS-CoV-2 , Estrés Psicológico/psicología , Control de Enfermedades Transmisibles , Ansiedad/epidemiología , Ansiedad/psicología , Estudiantes/psicología , Depresión/epidemiología , Depresión/psicología
12.
PLoS One ; 18(1): e0280156, 2023.
Artículo en Inglés | MEDLINE | ID: mdl-36662792

RESUMEN

This study serves to provide evidence on how the increase in people working from home due to government induced social distancing measures is contributing to the frequency of individuals suffering from depression or anxiety. Using a compilation of datasets from the NHIS, Household Pulse Survey, and the Oxford Covid-19 Response Tracker, we find a general trend of increased rates of depression and anxiety in those who moved to a remote working format. However, while all regions have an increased frequency in anxiety for those who switched to telework, those in the Northeast and West (that also have implemented strict lockdown measures related to social distancing) have slightly higher rates of anxiety compared to those in the South and Midwest.


Asunto(s)
COVID-19 , Humanos , Estados Unidos/epidemiología , COVID-19/epidemiología , Teletrabajo , SARS-CoV-2 , Depresión/epidemiología , Control de Enfermedades Transmisibles , Ansiedad/epidemiología
13.
Health Qual Life Outcomes ; 21(1): 5, 2023 Jan 20.
Artículo en Inglés | MEDLINE | ID: mdl-36670421

RESUMEN

BACKGROUND: Comorbid mental health conditions are common in people with epilepsy and have a significant negative impact on important epilepsy outcomes, although the evidence is mostly from high-income countries. This systematic review aimed to synthesise evidence on the association between comorbid mental health conditions and quality of life and functioning among people with epilepsy living in low- and middle income countries (LMICs). METHODS: We searched PubMed, EMBASE, CINAHL, Global Index medicus (GID) and PsycINFO databases from their dates of inception to January 2022. Only quantiative observational studies were included. Meta-analysis was conducted for studies that reported the same kind of quality of life and functioning outcome. Cohen's d was calculated from the mean difference in quality-of-life score between people with epilepsy who did and did not have a comorbid depression or anxiety condition. The protocol was registered with PROSPERO: CRD42020161487. RESULTS: The search strategy identified a total of 2,101 articles, from which 33 full text articles were included. Depression was the most common comorbid mental health condition (33 studies), followed by anxiety (16 studies). Meta-analysis was conducted on 19 studies reporting quality of life measured with the same instrument. A large standardized mean effect size (ES) in quality of life score was found (pooled ES = -1.16, 95% confidence interval (CI) - 1.70, - 0.63) between those participants with comorbid depression compared to non-depressed participants. There was significant heterogeneity between studies (I2 = 97.6%, p < 0.001). The median ES (IQR) was - 1.20 (- 1.40, (- 0.64)). An intermediate standard effect size for anxiety on quality of life was also observed (pooled ES = -0.64, 95% CI - 1.14, - 0.13). There was only one study reporting on functioning in relation to comorbid mental health conditions. CONCLUSION: Comorbid depression in people with epilepsy in LMICs is associated with poor quality of life although this evidence is based on highly heterogeneous studies. These findings support calls to integrate mental health care into services for people with epilepsy in LMICs. Future studies should use prospective designs in which the change in quality of life in relation to mental health or public health interventions across time can be measured.


Asunto(s)
Epilepsia , Salud Mental , Humanos , Países en Desarrollo , Calidad de Vida , Ansiedad/epidemiología , Epilepsia/complicaciones , Epilepsia/epidemiología
14.
J Exp Anal Behav ; 119(1): 209-230, 2023 Jan.
Artículo en Inglés | MEDLINE | ID: mdl-36597188

RESUMEN

This tribute to Howard Rachlin speculates about scholarly work that might have been. It explores how behavioral data might bear on philosophical issues, with examples that might be called case studies in experimental philosophy. In 1964, an issue of the Proceedings of the American Philosophical Society served a similar function. It was entitled "Psychology: A Behavioral Interpretation"; the papers included "Will," "Experience," "Appetite," "Humors," "Anxiety," and "Man." This presentation imagines what a contemporary project devoted to philosophical and behavior analytic perspectives on the topics of causation, freedom and volition, good and evil, time, words, and mind might have looked like. Along the way it notes how the project would have benefitted from Howard Rachlin's seminal contributions to both behavior analysis and philosophy. If ever such a project comes to pass, it will inevitably bear the stamp of his contributions.


Asunto(s)
Ansiedad , Filosofía , Masculino , Humanos , Estados Unidos , Trastornos de Ansiedad
15.
BMC Med ; 21(1): 7, 2023 Jan 05.
Artículo en Inglés | MEDLINE | ID: mdl-36600274

RESUMEN

BACKGROUND: Perioperative neurocognitive disorders (PND) with a high incidence frequently occur in elderly surgical patients closely associated with prolonged anesthesia-induced neurotoxicity. The neuromorphopathological underpinnings of anesthesia-induced neurotoxicity have remained elusive. METHODS: Prolonged anesthesia with sevoflurane was used to establish the sevoflurane-induced neurotoxicity (SIN) animal model. Morris water maze, elevated plus maze, and open field test were employed to track SIN rats' cognitive behavior and anxiety-like behaviors. We investigated the neuropathological basis of SIN through techniques such as transcriptomic, electrophysiology, molecular biology, scanning electron microscope, Golgi staining, TUNEL assay, and morphological analysis. Our work further clarifies the pathological mechanism of SIN by depleting microglia, inhibiting neuroinflammation, and C1q neutralization. RESULTS: This study shows that prolonged anesthesia triggers activation of the NF-κB inflammatory pathway, neuroinflammation, inhibition of neuronal excitability, cognitive dysfunction, and anxiety-like behaviors. RNA sequencing found that genes of different types of synapses were downregulated after prolonged anesthesia. Microglial migration, activation, and phagocytosis were enhanced. Microglial morphological alterations were also observed. C1qa, the initiator of the complement cascade, and C3 were increased, and C1qa tagging synapses were also elevated. Then, we found that the "Eat Me" complement pathway mediated microglial synaptic engulfment in the hippocampus after prolonged anesthesia. Afterward, synapses were remarkably lost in the hippocampus. Furthermore, dendritic spines were reduced, and their genes were also downregulated. Depleting microglia ameliorated the activation of neuroinflammation and complement and rescued synaptic loss, cognitive dysfunction, and anxiety-like behaviors. When neuroinflammatory inhibition or C1q neutralization occurred, complement was also decreased, and synaptic elimination was interrupted. CONCLUSIONS: These findings illustrated that prolonged anesthesia triggered neuroinflammation and complement-mediated microglial synaptic engulfment that pathologically caused synaptic elimination in SIN. We have demonstrated the neuromorphopathological underpinnings of SIN, which have direct therapeutic relevance for PND patients.


Asunto(s)
Anestesia , Disfunción Cognitiva , Enfermedades Neuroinflamatorias , Animales , Ratas , Anestesia/efectos adversos , Ansiedad/etiología , Ansiedad/metabolismo , Disfunción Cognitiva/etiología , Disfunción Cognitiva/metabolismo , Complemento C1q/metabolismo , Hipocampo/metabolismo , Microglía/efectos de los fármacos , Microglía/fisiología , Enfermedades Neuroinflamatorias/inducido químicamente , Enfermedades Neuroinflamatorias/complicaciones , Sevoflurano/efectos adversos , Sevoflurano/metabolismo
16.
J Med Internet Res ; 25: e38333, 2023 Jan 06.
Artículo en Inglés | MEDLINE | ID: mdl-36607712

RESUMEN

BACKGROUND: Digital care has become an essential component of health care. Interventions for patients with cancer need to be effective and safe, and digital health interventions must adhere to the same requirements. OBJECTIVE: The purpose of this study was to identify currently available digital health interventions developed and evaluated in randomized controlled trials (RCTs) targeting adult patients with cancer. METHODS: A scoping review using the JBI methodology was conducted. The participants were adult patients with cancer, and the concept was digital health interventions. The context was open, and sources were limited to RCT effectiveness studies. The PubMed, CINAHL, Embase, Cochrane Library, Research Information Sharing Service, and KoreaMed databases were searched. Data were extracted and analyzed to achieve summarized results about the participants, types, functions, and outcomes of digital health interventions. RESULTS: A total of 231 studies were reviewed. Digital health interventions were used mostly at home (187/231, 81%), and the web-based intervention was the most frequently used intervention modality (116/231, 50.2%). Interventions consisting of multiple functional components were most frequently identified (69/231, 29.9%), followed by those with the self-manage function (67/231, 29%). Web-based interventions targeting symptoms with the self-manage and multiple functions and web-based interventions to treat cognitive function and fear of cancer recurrence consistently achieved positive outcomes. More studies supported the positive effects of web-based interventions to inform decision-making and knowledge. The effectiveness of digital health interventions targeting anxiety, depression, distress, fatigue, health-related quality of life or quality of life, pain, physical activity, and sleep was subject to their type and function. A relatively small number of digital health interventions specifically targeted older adults (6/231, 2.6%) or patients with advanced or metastatic cancer (22/231, 9.5%). CONCLUSIONS: This scoping review summarized digital health interventions developed and evaluated in RCTs involving adult patients with cancer. Systematic reviews of the identified digital interventions are strongly recommended to integrate digital health interventions into clinical practice. The identified gaps in digital health interventions for cancer care need to be reflected in future digital health research.


Asunto(s)
Recurrencia Local de Neoplasia , Calidad de Vida , Humanos , Anciano , Ensayos Clínicos Controlados Aleatorios como Asunto , Ansiedad/terapia , Ejercicio Físico
17.
J Affect Disord ; 324: 600-606, 2023 Mar 01.
Artículo en Inglés | MEDLINE | ID: mdl-36610594

RESUMEN

BACKGROUND: Studying the role of psychological resilience in self-perceived stress and mental disorders among family members of medical workers can help us understand its importance in mental health care and guide us to develop psychological intervention strategies for family members of medical workers. METHODS: A total of 671 family members of medical workers were enrolled. Self-perceived stress, resilience, depression symptoms, anxiety symptoms, and post-traumatic stress disorder (PTSD) symptoms were measured in our research. RESULTS: The prevalence of anxiety, depression, and PTSD symptoms among relatives of medical workers were 49.0 %, 12.2 %, and 20.3 % respectively during the COVID-19 epidemic. According to the Multivariate regression model, compared with family members of doctor, family members of nurse and medical technologists were more likely to report anxiety symptoms. Female members of medical staff were more likely to have PTSD symptoms than male counterparts; and family members of medical technologist appeared to less likely have PTSD symptoms than family members of either doctor or nurse. The mediation analysis confirmed that mental resilience mediated the relationship between self-perceived stress and anxiety symptoms. LIMITATIONS: Single cross-sectional study design without the follow-up comparative analysis, only self-reported measurements were adopted, and inadequate pre-set demographic variables. CONCLUSIONS: To the best of our knowledge, our study firstly demonstrated the risk of psychological distress present in the family members of medical providers during the COVID-19 epidemic. Meanwhile, our findings highlighted the importance of mental resilience in family members of frontline medical workers as it mediated the relationship between self-perceived stress and anxiety symptoms.


Asunto(s)
COVID-19 , Trastornos por Estrés Postraumático , Humanos , Masculino , Femenino , SARS-CoV-2 , Estudios Transversales , Depresión/epidemiología , Depresión/psicología , Salud Mental , Personal de Salud/psicología , Ansiedad/epidemiología , Ansiedad/psicología , Trastornos por Estrés Postraumático/epidemiología
18.
J Affect Disord ; 324: 632-636, 2023 Mar 01.
Artículo en Inglés | MEDLINE | ID: mdl-36610598

RESUMEN

BACKGROUND: SARS-COV-2 vaccination is being carried out worldwide. However, little is known about the effect of SARS-COV-2 vaccination on psychological problems faced by the medical staff. This study aimed to examine the prevalence and factors contributing to anxiety and depression among medical staff facing SARS-COV-2 vaccination. METHODS: The GAD-7 and the PHQ-9 scales were used to investigate the anxiety and depression among participants involved in SARS-CoV-2 vaccination. Multivariate logistics regression analysis method was used to assess the risk factors related to anxiety or depression. RESULTS: A total of 6984 people responded to all the surveyed questions in our study, including 2707 medical staff and 4277 nonmedical staff. Of the participants, 680 reported anxiety, while 1354 reported depression. Higher anxiety levels were observed among medical staff (13.1 % vs. 7.6 % among the non-medical staff). Participants suffered from depression with higher numbers among medical staff (24.7 % vs. 16.0 % among the non-medical staff). Multivariate logistic regression analysis showed that female medical staff was at higher risk of anxiety and depression compared to their male counterparts (OR = 1.497; OR = 1.417). Pregnancy intention increased the risk of anxiety and depression among medical staff (OR = 1.601; OR = 1.724). LIMITATIONS: Our findings may not be extrapolated to other countries. CONCLUSION: Medical staff facing SARS-CoV-2 vaccination were more likely to suffer from anxiety or depression, especially the females planning for pregnancy. These results should assist in updating intervention guidelines for the mental health of medical staff facing vaccination.


Asunto(s)
Vacunas contra la COVID-19 , COVID-19 , SARS-CoV-2 , Femenino , Humanos , Masculino , Ansiedad/epidemiología , Ansiedad/psicología , China/epidemiología , COVID-19/epidemiología , COVID-19/prevención & control , COVID-19/psicología , Vacunas contra la COVID-19/efectos adversos , Depresión/epidemiología , Depresión/psicología
19.
J Affect Disord ; 324: 645-651, 2023 Mar 01.
Artículo en Inglés | MEDLINE | ID: mdl-36610599

RESUMEN

OBJECTIVES: The aim of the study was to explore the cognitive functions of a large sample of hospitalised subjects with mild symptomatic Coronavirus Disease (COVID-19) who were previously independent at home and without neurological diseases. METHODS: Patients admitted in a COVID-19 Unit for Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) infection between November 2020 and March 2021 were recruited. Inclusion criteria were: being independent at home before the infection, radiologically confirmed COVID-19 pneumonia, positive reverse transcriptase-polymerase chain reaction nasopharyngeal swab and no oxygen supplementation at the time of evaluation. EXCLUSION CRITERIA: cognitive impairment or neurological diseases previous to the infection, delirium episodes, and history of any mechanical ventilation use. They were evaluated with Montreal Cognitive Assessment (MoCA), Hamilton Depression Rating Scale (HAM-D) and Hamilton Anxiety Rating Scale (HAM-A). RESULTS: Out of 522 subjects admitted in the COVID-19 Unit, 90 were enrolled [mean age = 68.32(11.99); 46M/44F]. An impaired MoCA (cut-off < 23) was found in 60 subjects (66.66 %). Pathological scores were obtained by 36.7 % of the subjects with <65 years and 78.3 % of those older than 65 years. A high prevalence of executive function and memory impairment was detected. CONCLUSIONS: The results underline a high rate of cognitive impairment in previously independent mild COVID-19 patients. This might represent a potential threat for the everyday independence of these patients due to the consequences on everyday life activities and work following discharge from hospital. These subjects should, therefore, be monitored in order to allow a better understanding of the progression and consequences of the so-called "Long COVID".


Asunto(s)
COVID-19 , Disfunción Cognitiva , Enfermedades del Sistema Nervioso , Humanos , Anciano , SARS-CoV-2 , Hospitalización , Ansiedad/epidemiología , Disfunción Cognitiva/diagnóstico , Disfunción Cognitiva/epidemiología , Disfunción Cognitiva/etiología
20.
Sci Rep ; 13(1): 1434, 2023 Jan 25.
Artículo en Inglés | MEDLINE | ID: mdl-36697477

RESUMEN

Exposure to traumatic experiences across lifespan shapes the functioning of the hypothalamic pituitary adrenal (HPA) axis and sets individuals at risk to develop symptoms of depression and anxiety. Particularly, HPA axis regulation and the psychological health of the expectant mother have been of interest, as the health of the unborn child may be affected through changes in gestational biology. The present study investigated the potential associations between lifetime trauma, current symptoms (depression and anxiety) and hair cortisol concentrations (HCC) in pregnant women. A total of 149 pregnant women were interviewed in public outpatient clinics with varying gestational age in Greece, Spain and Perú. Lifetime trauma exposure and current symptoms of depression and anxiety were assessed. HCC was measured in scalp-near hair segments (2 cm length) reflecting cumulative cortisol secretion of the past two months. Results showed that trauma load is negatively associated with HCC and higher symptoms of depression and anxiety. There was a negative association between HCC and symptoms. The present findings support the notion that cumulative trauma exposure exerts long-lasting effects on the expectant mother's HPA axis activity functioning and mental health and may thereby potentially create risk trajectories for the unborn child via changes in gestational biology.


Asunto(s)
Hidrocortisona , Mujeres Embarazadas , Humanos , Femenino , Embarazo , Depresión/psicología , Sistema Hipotálamo-Hipofisario , Grecia/epidemiología , Perú , España/epidemiología , Sistema Hipófiso-Suprarrenal , Ansiedad , Cabello , Estrés Psicológico/psicología
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