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1.
Rev. Asoc. Méd. Argent ; 132(4): 15-19, dic. 2019. ilus
Artículo en Español | LILACS | ID: biblio-1087168

RESUMEN

El mesotelioma difuso es una neoplasia maligna poco frecuente que proviene de las células mesoteliales; la pleura es su localización más habitual y se estima que un 10% de los casos se localizan a nivel peritoneal. El mesotelioma es habitualmente diagnosticado en la quinta década de la vida, con un claro predominio en el sexo masculino, debido esto último a su relación con la exposición laboral al asbesto. Se expone un caso con factores de riesgo y diagnóstico asociado. (AU)


Diffuse mesothelioma is a rare malignant neoplasm that comes from mesothelial cells; the pleura are the most common location and is estimated that 10% of the cases are located at the peritoneal level. Mesothelioma is usually diagnosed in the fifth decade of life, with a clear predominance in the male sex, due to its relation to occupational exposureto asbestos. A case is presented with risk factors and associated diagnosis. (AU)


Asunto(s)
Humanos , Masculino , Persona de Mediana Edad , Neoplasias Pleurales/diagnóstico por imagen , Tomografía Computarizada Multidetector , Mesotelioma/etiología , Mesotelioma/diagnóstico por imagen , Asbestos/efectos adversos , Diagnóstico Diferencial , Mesotelioma/terapia , Estadificación de Neoplasias
2.
Ig Sanita Pubbl ; 75(4): 303-312, 2019.
Artículo en Italiano | MEDLINE | ID: mdl-31887736

RESUMEN

The term asbestos refers to six unique fibrous minerals mostly used in the production of asbestos cement sheets and pipes. According to the World Health Organization and the International Agency for Research on Cancer (IARC), there exists at least "sufficient evidence" that all types of asbestos may cause cancer in humans (mesothelioma, lung cancer, laryngeal tumor and ovarian cancer). The only asbestos limit in drinking water is 7 million fiber/liter. This study is a narrative synthesis about the possible hazards to human health related to the presence of asbestos in drinking water. The various scientific studies and epidemiological reports examined highlight that there is an ongoing debate on the possible carcinogenic risk associated with asbestos exposure through ingestion. Nevertheless, considering the latency with which diseases caused by asbestos may emerge, control measures should be adopted.


Asunto(s)
Asbestos/efectos adversos , Agua Potable/análisis , Exposición a Riesgos Ambientales/efectos adversos , Contaminantes Químicos del Agua/toxicidad , Asbestos/toxicidad , Carcinógenos , Humanos , Neoplasias Pulmonares/etiología , Neoplasias Pulmonares/prevención & control , Mesotelioma/etiología , Mesotelioma/prevención & control
3.
BMC Res Notes ; 12(1): 636, 2019 Sep 30.
Artículo en Inglés | MEDLINE | ID: mdl-31564247

RESUMEN

OBJECTIVE: Asbestos was widely used in construction in both a friable and a compact form until the 1990s, before its use was banned. Today, many of these materials are still in situ and represent a source of risk for construction workers. The objective of the study was to analyse the cases of mesothelioma arising among construction workers registered in the Apulia regional register of mesothelioma. RESULTS: For the period 1993-2018, there were 178 male cases, and 10.2% of the cases were present in the regional register. The average age at diagnosis was 64.7 years. The site was pleural in 96.06% of cases, with a diagnosis of certainty in 86.5% of the total cases and 61.8% of cases with epithelial histology. The average latency is 43.9 years. In 75.2% of cases, the exposure began between 1941 and 1970, with an average duration of 24.3 years. The age at the start of exposure in 68.5% of cases is between 8 and 20 years. The ORs were 2.5 (C.I. 95% 1.01-6.17) for the epithelioid histotype and the high duration of exposure. The data underline the need for prevention and information on all activities involving construction workers in which asbestos-containing materials are still used.


Asunto(s)
Asbestos/efectos adversos , Exposición a Riesgos Ambientales/efectos adversos , Neoplasias Pulmonares/epidemiología , Mesotelioma/epidemiología , Exposición Profesional/efectos adversos , Sistema de Registros , Adulto , Anciano , Anciano de 80 o más Años , Industria de la Construcción/instrumentación , Humanos , Incidencia , Italia/epidemiología , Pulmón/efectos de los fármacos , Pulmón/patología , Neoplasias Pulmonares/inducido químicamente , Neoplasias Pulmonares/diagnóstico , Neoplasias Pulmonares/patología , Masculino , Mesotelioma/inducido químicamente , Mesotelioma/diagnóstico , Mesotelioma/patología , Persona de Mediana Edad
5.
Laeknabladid ; 105(7): 327-334, 2019.
Artículo en Islandés | MEDLINE | ID: mdl-31411568

RESUMEN

Asbestos are crystallized silicate minerals that form fibers with different structures and characteristics. Asbestos fibers are very durable and can tolerate very high temperatures. Therefore it was common to use asbestos as a fire retardants, heat insulation and where high temperature is used. Asbestos has been banned in Iceland from 1983 but can still be found in large amounts in buildings, ships and hot water pipes. Large amounts of asbestos were imported in the years before the ban but diminished soon to almost nothing today. Needle or filamentous shaped dust is released when working with asbestos. It is this dust that is dangerous for health. The latent time from exposure to disease can be up to forty years. Asbestos reaches the lungs via inhalation and can cause asbestosis that is a form of lung fibrosis with slow progression. Asbestos can also cause benign pleural effusions, pleural plaques and diffuse pleural thickening. Asbestos is a carcinogen. Lung cancer is most common but asbestos is also a risk factor for cancers of other organs. Mesothelioma is most common in the pleura but can be seen in other membranes. The incidence of these tumors is high in Iceland and is still increasing among males. Of all the European countries mortality is highest in Iceland. It is important for physicians to include asbestos exposure in the differential diagnosis of lung diseases and when lung cancer is diagnosed.


Asunto(s)
Asbestos/efectos adversos , Asbestosis/epidemiología , Materiales de Construcción/efectos adversos , Exposición a Riesgos Ambientales/efectos adversos , Neoplasias Pulmonares/epidemiología , Mesotelioma/epidemiología , Anciano , Anciano de 80 o más Años , Asbestosis/diagnóstico por imagen , Asbestosis/patología , Femenino , Humanos , Islandia/epidemiología , Incidencia , Neoplasias Pulmonares/diagnóstico por imagen , Neoplasias Pulmonares/patología , Masculino , Mesotelioma/diagnóstico , Persona de Mediana Edad , Medición de Riesgo , Factores de Riesgo , Distribución por Sexo , Factores de Tiempo
6.
Occup Environ Med ; 76(9): 611-616, 2019 09.
Artículo en Inglés | MEDLINE | ID: mdl-31413184

RESUMEN

OBJECTIVES: Models based on the multistage theory of cancer predict that rates of malignant mesothelioma continuously increase with time since first exposure (TSFE) to asbestos, even after the end of external exposure. However, recent epidemiological studies suggest that mesothelioma rates level off many years after first exposure to asbestos. A gradual clearance of asbestos from the lungs has been suggested as a possible explanation for this phenomenon. We analysed long-term trends of pleural and peritoneal cancer mortality in subjects exposed to asbestos to evaluate whether such trends were consistent with the clearance hypothesis. METHODS: We used data from a pool of 43 Italian asbestos cohorts (51 801 subjects). The role of asbestos clearance was explored using the traditional mesothelioma multistage model, generalised to include a term representing elimination of fibres over time. RESULTS: Rates of pleural cancer increased until 40 years of TSFE, but remained stable thereafter. On the other hand, we observed a monotonic increase of peritoneal cancer with TSFE. The model taking into account asbestos clearance fitted the data better than the traditional one for pleural (p=0.004) but not for peritoneal (p=0.09) cancer. CONCLUSIONS: Rates of pleural cancer do not increase indefinitely after the exposure to asbestos, but eventually reach a plateau. This trend is well described by a model accounting for a gradual elimination of the asbestos fibres. These results are relevant for the prediction of future rates of mesothelioma and in asbestos litigations.


Asunto(s)
Asbestos/efectos adversos , Enfermedades Profesionales/mortalidad , Exposición Profesional/efectos adversos , Neoplasias Peritoneales/mortalidad , Neoplasias Pleurales/mortalidad , Adolescente , Adulto , Femenino , Humanos , Italia/epidemiología , Masculino , Persona de Mediana Edad , Modelos Teóricos , Factores de Tiempo , Adulto Joven
7.
Rev Med Suisse ; 15(658): 1416-1417, 2019 Aug 14.
Artículo en Francés | MEDLINE | ID: mdl-31411837
8.
BMJ Case Rep ; 12(7)2019 Jul 08.
Artículo en Inglés | MEDLINE | ID: mdl-31289169

RESUMEN

We describe a case of a deciduoid mesothelioma, a rare variant of epithelioid mesothelioma, which is associated with a very poor prognosis. A review of the relevant literature is also included. The patient was a man with probable asbestos exposure and presented with classic features of pleural malignancy. Diagnosis was reached with close correlation between clinical, radiological and pathological findings.


Asunto(s)
Asbestos/efectos adversos , Deciduoma/patología , Neoplasias Pulmonares/patología , Mesotelioma/patología , Anciano , Exposición a Riesgos Ambientales , Humanos , Neoplasias Pulmonares/diagnóstico por imagen , Neoplasias Pulmonares/metabolismo , Masculino , Mesotelioma/diagnóstico por imagen , Mesotelioma/metabolismo , Cuidados Paliativos/métodos , Neoplasias Pleurales/diagnóstico por imagen , Neoplasias Pleurales/patología , Pronóstico , Toracoscopía/métodos , Tomografía Computarizada por Rayos X/métodos
10.
BMC Cancer ; 19(1): 507, 2019 May 28.
Artículo en Inglés | MEDLINE | ID: mdl-31138176

RESUMEN

BACKGROUND: Deletion of the CDKN2A locus is centrally involved in the development of several malignancies. In malignant pleural mesothelioma (MPM), it is one of the most frequently reported genomic alteration. MPM is strongly associated with a patients' asbestos exposure. However, the status of CDKN2A and the expression of the corresponding protein, p16, in relation to MPM patient's asbestos exposure is poorly known. Copy number alterations in 2p16, 9q33.1 and 19p13 have earlier been shown to accumulate in lung cancer in relation to asbestos exposure but their status in MPM is unclear. METHODS: We studied DNA copy numbers for CDKN2A using fluorescence in situ hybridization (FISH) and p16 expression by immunohistochemistry (IHC) in 92 MPM patients, 75 of which with known asbestos exposure status. We also studied, in MPM, copy number alterations in 2p16, 9q33.1 and 19p13 by FISH. RESULTS: We were unable to detect an association between p16 expression and pulmonary asbestos fiber count in MPM tumor cells. However, significantly more MPM patients with high pulmonary asbestos fiber count (> 1 million fibers per gram [f/g]) had stromal p16 immunoreactivity than MPM of patients with low exposure (≤ 0.5 million f/g) (51.4% vs 16.7%; p = 0.035, Chi-Square). We found that an abnormal copy number of CDKN2A in MPM tumor cells associated with a high pulmonary asbestos fiber count (p = 0.044, Fisher's Exact test, two-tailed). In contrast to our earlier findings in asbestos associated lung cancer, DNA copy number changes in 2p16, 9q33 and 19p13 were not frequent in MPM although single cases with variable copy numbers on those regions were seen. CONCLUSIONS: We found two instances where the gene locus CDKN2A or its corresponding protein expression, is associated with high asbestos exposure levels. This suggests that there may be biological differences between the mesotheliomas with high pulmonary asbestos fiber count and those with low fiber count.


Asunto(s)
Asbestos/efectos adversos , Inhibidor p16 de la Quinasa Dependiente de Ciclina/genética , Inhibidor p16 de la Quinasa Dependiente de Ciclina/metabolismo , Variaciones en el Número de Copia de ADN , Neoplasias Pulmonares/metabolismo , Mesotelioma/metabolismo , Anciano , Cromosomas Humanos/genética , Femenino , Regulación Neoplásica de la Expresión Génica , Humanos , Hibridación Fluorescente in Situ , Neoplasias Pulmonares/inducido químicamente , Neoplasias Pulmonares/genética , Masculino , Mesotelioma/inducido químicamente , Mesotelioma/genética , Persona de Mediana Edad , Células del Estroma/metabolismo , Análisis de Matrices Tisulares
11.
Lung Cancer ; 131: 23-30, 2019 05.
Artículo en Inglés | MEDLINE | ID: mdl-31027694

RESUMEN

OBJECTIVES: Smoking is the main risk factor for lung cancer, but environmental and occupational exposure to carcinogens also increase lung cancer risk. We assessed whether extending low-dose computed tomography (LDCT) screening to persons with occupational exposure to asbestos may be an effective way reducing lung cancer mortality. MATERIALS AND METHODS: We conducted a nested case-control study within the COSMOS screening program, assessing past asbestos exposure with a questionnaire. LDCT scans of asbestos-exposed participants were reviewed to assess the presence of pulmonary, interstitial and pleural alterations in comparison to matched unexposed controls. We also performed an exhaustive review, with meta-analysis, of the literature on LDCT screening in asbestos-exposed persons. RESULTS: Exposure to asbestos, initially self-reported by 9.8% of COSMOS participants, was confirmed in 216 of 544 assessable cases, corresponding to 2.6% of the screened population. LDCT of asbestos-exposed persons had significantly more pleural plaques, diaphragmatic pleural thickening and pleural calcifications, but similar frequency of parenchymal and interstitial alterations to unexposed persons. From 16 papers, including this study, overall lung cancer detection rates at baseline were 0.81% (95% CI 0.50-1.19) in asbestos-exposed persons, 0.94% (95% CI 0.47-1.53) in asbestos-exposed smokers (12 studies), and 0.11% (95% CI 0.00-0.43) in asbestos-exposed non-smokers (9 studies). CONCLUSION: Persons occupationally exposed to asbestos should be monitored to gather more information about risks. Although LDCT screening is effective in the early detection lung cancer in asbestos-exposed smokers, our data suggest that screening of asbestos-exposed persons with no additional risk factors for cancer does is not viable due to the low detection rate.


Asunto(s)
Asbestos/efectos adversos , Detección Precóz del Cáncer/métodos , Neoplasias Pulmonares/diagnóstico , Exposición Profesional/efectos adversos , Pleura/patología , Tomografía Computarizada por Rayos X/métodos , Anciano , Anciano de 80 o más Años , Estudios de Casos y Controles , Fumar Cigarrillos/efectos adversos , Femenino , Humanos , Italia/epidemiología , Neoplasias Pulmonares/epidemiología , Neoplasias Pulmonares/mortalidad , Masculino , Persona de Mediana Edad , Pleura/diagnóstico por imagen , Riesgo , Encuestas y Cuestionarios , Análisis de Supervivencia
12.
Cancer Epidemiol ; 60: 162-167, 2019 06.
Artículo en Inglés | MEDLINE | ID: mdl-31030080

RESUMEN

BACKGROUND: This study is part of a national plan of epidemiological surveillance of malignant mesothelioma (MM) mortality in Italy. The paper shows the results of malignant peritoneal mesothelioma (MPeM) mortality study in Italian Regions and municipalities. METHODS: National Bureau of Statistics data for MPeM municipal mortality (ICD-10, Code C45.1) were analyzed in the time-window 2003-2014: mortality standardized rates (reference Italian population, census 2011), temporal trends of the annual national rates, Standardized Mortality Ratios and a municipal clustering analysis were performed. RESULTS: 747 deaths for MPeM were recorded (0.10/100,000): 464 in men (0.14/100,000) and in 283 women (0.07/100,000). No significant MPeM mortality temporal trend was found. Seventeen municipalities showed excesses of mortality for MPeM in at least one gender and/or overall population. Four clusters in male population, and one in women were identified. CONCLUSIONS: The study identifies some areas where remediation activities and/or health care actions may be warranted.


Asunto(s)
Asbestos/efectos adversos , Neoplasias Pulmonares/epidemiología , Mesotelioma/epidemiología , Neoplasias Peritoneales/epidemiología , Adulto , Anciano , Femenino , Humanos , Italia , Neoplasias Pulmonares/mortalidad , Masculino , Mesotelioma/mortalidad , Persona de Mediana Edad , Neoplasias Peritoneales/mortalidad , Análisis Espacial
13.
PLoS One ; 14(4): e0214808, 2019.
Artículo en Inglés | MEDLINE | ID: mdl-30946771

RESUMEN

Workers processing nephrite, antigorite, or talc may be exposed to paragenetic asbestos minerals. An effective screening method for pneumoconiosis in workers exposed to asbestos-contaminated minerals is still lacking. The objective of this study was to assess the diagnostic accuracy of serum and urinary biomarkers for pneumoconiosis in workers exposed to asbestos-contaminated minerals. We conducted a case-control study in a cohort of stone craft workers in Hualien, where asbestos, nephrite, antigorite, and talc are produced. A total of 140 subjects were screened between March 2013 and July 2014. All subjects received a questionnaire survey and a health examination that included a physical examination; chest X-ray; and tests for standard pulmonary function, fractional exhaled nitric oxide, serum soluble mesothelin-related peptide (SMRP), fibulin-3, carcinoembryonic antigen (CEA), and urinary 8-Oxo-2'-deoxyguanosine (8-OHdG)/creatinine. After excluding subjects with uraemia and chronic obstructive pulmonary disease (COPD), we included 48 subjects with pneumoconiosis and 90 control subjects without pneumoconiosis for analysis. In terms of occupational history, 43/48 (90%) case subjects and 68% (61/90) of the control subjects had processed asbestos-contaminated minerals, including nephrite, antigorite, and talc. The case group had decreased pulmonary function in forced vital capacity (FVC), forced expiratory volume in one second, and forced expiratory flow between 25% and 75% of the FVC. The levels of SMRP, fibulin-3, urinary 8-OHdG/creatinine, and CEA were higher in the case group than in the control group. Subjects exposed to nephrite had significantly higher SMRP levels (0.84 ± 0.52 nM) than subjects exposed to other types of minerals (0.60 ± 0.30 nM). A dose-response relationship was observed between the SMRP level and the severity of pneumoconiosis. Machine learning algorithms, including variables of sex, age, SMRP, fibulin-3, CEA, and 8-OHdG/creatinine, can predict pneumoconiosis with high accuracy. The areas under the receiver operating characteristic curves ranged from 0.7 to 1.0. We suggest that SMRP and fibulin-3 could be used as biomarkers of pneumoconiosis in workers exposed to asbestos-contaminated minerals.


Asunto(s)
Asbestos/efectos adversos , Exposición Profesional , Neumoconiosis/sangre , Neumoconiosis/orina , /sangre , Adulto , Anciano , Asbestos Serpentinas/efectos adversos , Asbestosis/sangre , Asbestosis/fisiopatología , Asbestosis/orina , Biomarcadores/sangre , Biomarcadores/orina , Antígeno Carcinoembrionario/sangre , Antígeno Carcinoembrionario/orina , Estudios de Casos y Controles , Estudios de Cohortes , Creatinina/sangre , Creatinina/orina , Proteínas de la Matriz Extracelular/sangre , Proteínas de la Matriz Extracelular/orina , Femenino , Volumen Espiratorio Forzado , Proteínas Ligadas a GPI/sangre , Proteínas Ligadas a GPI/orina , Humanos , Masculino , Flujo Espiratorio Medio Máximo , Persona de Mediana Edad , Minerales/efectos adversos , Exposición Profesional/efectos adversos , Exposición Profesional/análisis , Neumoconiosis/fisiopatología , Taiwán , Talco/efectos adversos , Capacidad Vital
15.
Ann Ist Super Sanita ; 55(1): 70-79, 2019.
Artículo en Inglés | MEDLINE | ID: mdl-30968841

RESUMEN

INTRODUCTION: Numerous municipalities in Italy currently experience asbestos health impact, in particular excesses of pleural mesothelioma incidence and mortality. This paper presents an integrated analysis of epidemiological studies and communication actions in affected municipalities to highlight how communication has been implemented depending on health impact evidence and involvement of local stakeholders. METHODOLOGY: Four case studies are identified concerning industrial and natural sources of asbestos exposure having different diseases burden. This integrated analysis benefited from multidisciplinary skills. DISCUSSION: Evidence of different stakeholders engagement is presented to emphasize their role in the communication process. Similarities and differences among case studies allowed us to identify lessons-learned to be transferred in other asbestos contaminated sites. CONCLUSIONS: The adoption of communication strategies and practices, since the very early evidence of asbestos health impact, represents a relevant contribution for epidemiological and health surveillance, particularly for those communities where asbestos health impact has only been recently reported.


Asunto(s)
Asbestos/efectos adversos , Asbestosis/epidemiología , Educación en Salud/estadística & datos numéricos , Asbestosis/prevención & control , Comunicación , Exposición a Riesgos Ambientales , Humanos , Incidencia , Italia/epidemiología , Neoplasias/epidemiología , Neoplasias/etiología , Exposición Profesional , Vigilancia en Salud Pública
16.
Ann Ist Super Sanita ; 55(1): 94-99, 2019.
Artículo en Inglés | MEDLINE | ID: mdl-30968844

RESUMEN

In contexts of social and environmental disasters, practices of memory and narration can become actions implemented by the affected groups to cope with the suffering related to the disaster experience, to mobilise in the name of social justice, and to favour those dynamics by which the survivors develop their sense of being part of a community. This article is based on qualitative data collected through an anthropological study based on ethnographic fieldwork conducted in Italy and Brazil. It discusses the practices by which the survivors of the impact of asbestos-related disaster on their lives make sense of their suffering experience and engage in a grassroots health-based movement. Attention is paid on the social aspects of the health impact of asbestos exposure, and the role of the affected communities in the elaboration of their own paths of care by remembering and communicating the disaster is considered.


Asunto(s)
Asbestos/efectos adversos , Asbestosis/prevención & control , Contaminación Ambiental/efectos adversos , Asbestosis/epidemiología , Brasil , Humanos , Italia , Narración , Justicia Social , Apoyo Social
17.
BMJ Case Rep ; 12(3)2019 Mar 31.
Artículo en Inglés | MEDLINE | ID: mdl-30936339

RESUMEN

India is the largest consumer of asbestos in the world. There is no report from India of mesothelioma related to asbestos. The case is a 42-year-old man who died of pleural mesothelioma. He was exposed to asbestos domestically and from the environment since birth. Two of his close family members worked in a factory that used asbestos. The living quarter of the family was within the premises of the factory. Asbestos waste was strewn on the grounds surrounding the quarters. After decades of legal battles by workers and families exposed to asbestos, Indian courts have ordered remedial measures and compensation to people, who are exposed to asbestos at work and the environment. Mesothelioma, currently in epidemic proportions in the west where asbestos production was banned in the 1990s, could rise to alarming levels in the next decades in India if the legal remedial measures are not implemented soon.


Asunto(s)
Contaminantes Ocupacionales del Aire/efectos adversos , Asbestos/efectos adversos , Exposición a Riesgos Ambientales/efectos adversos , Neoplasias Pulmonares/diagnóstico , Mesotelioma/diagnóstico , Exposición Profesional/efectos adversos , Neoplasias Pleurales/diagnóstico , Adulto , Compensación y Reparación/legislación & jurisprudencia , Exposición a Riesgos Ambientales/legislación & jurisprudencia , Resultado Fatal , Humanos , India , Neoplasias Pulmonares/inducido químicamente , Neoplasias Pulmonares/mortalidad , Masculino , Mesotelioma/inducido químicamente , Mesotelioma/mortalidad , Exposición Profesional/legislación & jurisprudencia , Neoplasias Pleurales/inducido químicamente , Neoplasias Pleurales/mortalidad , Indemnización para Trabajadores/legislación & jurisprudencia
18.
Wien Klin Wochenschr ; 131(9-10): 200-204, 2019 May.
Artículo en Inglés | MEDLINE | ID: mdl-30874891

RESUMEN

After one of Austria's largest environmental scandals in 2014, which involved the release of hexachlorobenzene (HCB) in the Carinthian valley Görtschitztal, concerns about increased cancer rates have arísen in the affected local population. A descriptive study was conducted to examine the cancer incidence rates between 1983 and 2012. Data from the affected area (Görtschitztal, district St. Veit) were compared to data from the neighboring area within the same district and Carinthia excluding St. Veit, considering incidence rates of liver, lung, kidney, thyroid cancer and mesothelioma. Prostate cancer and carcinoma in situ were both included and excluded from overall cancer incidents in order to prevent potential bias due to screening programs. Considering the observed variability at an overall level, no conspicuous differences in cancer incidences could be found (Carinthia: 495, St. Veit West: 408, St. Veit East: 572 cases per 100,000 person-years in 2012). For some cancer types, e. g. liver, thyroid cancer and mesothelioma, the affected region showed a higher increase in rates than the neighboring area or Carinthia overall; however, these increased rates date back to a time prior to the HCB exposure, suggesting other carcinogenic influences, such as asbestos exposure from antecedent years.


Asunto(s)
Hexaclorobenceno/efectos adversos , Neoplasias/epidemiología , Asbestos/efectos adversos , Austria/epidemiología , Humanos , Incidencia , Neoplasias Pulmonares/epidemiología , Mesotelioma/epidemiología
19.
Cancer Sci ; 110(5): 1518-1524, 2019 May.
Artículo en Inglés | MEDLINE | ID: mdl-30888083

RESUMEN

Primarily caused by exposure to asbestos, mesothelioma is a typical occupational disease. The latency of mesothelioma is as long as 20-40 years, and the cancer initially progresses mainly along the surfaces of pleura or peritoneum without forming masses. As symptoms do not develop until late stages, it has been challenging to diagnose this disease in its early stages and to carry out complete surgical removal. In responding to Japan's asbestos crisis in the mid-2000s, we have developed and improved ERC/MSLN-based serum and radiological markers and pioneered the use of an N-ERC ELISA kit for screening populations at risk for asbestos exposure. In the present article, we review our research toward early diagnosis of asbestos-related mesothelioma before symptoms develop and share our clinical experience of screening, diagnosing and monitoring of this disease. This paper is dedicated to the author (Dr Okio Hino) to commemorate the honor bestowed upon him as the recipient of the Mataro Nagayo Prize in 2018.


Asunto(s)
Asbestos/efectos adversos , Detección Precóz del Cáncer/métodos , Neoplasias Pulmonares/diagnóstico , Neoplasias Pulmonares/cirugía , Mesotelioma/diagnóstico , Mesotelioma/cirugía , Proteínas Oncogénicas/sangre , Animales , Distinciones y Premios , Biomarcadores de Tumor/sangre , Manejo de la Enfermedad , Humanos , Japón , Neoplasias Pulmonares/sangre , Neoplasias Pulmonares/inducido químicamente , Mesotelioma/sangre , Mesotelioma/inducido químicamente , Enfermedades Profesionales/inducido químicamente , Enfermedades Profesionales/diagnóstico , Enfermedades Profesionales/cirugía
20.
Occup Environ Med ; 76(6): 407-413, 2019 06.
Artículo en Inglés | MEDLINE | ID: mdl-30804166

RESUMEN

OBJECTIVE: To examine the risk of malignant mesothelioma (MM) in former pupils who attended primary school near an asbestos cement plant. METHODS: A cohort of 12 111 former pupils, born 1940-1970, was established from individual historical records from four primary schools located at a distance of 100-750 m in the prevailing wind direction from an asbestos cement plant operating from 1928 to 1984 in Aalborg, Denmark. The school cohort and a comparison cohort consisting of 108 987 gender and 5-year frequency-matched subjects were followed up (2015) for MM in the Danish Cancer Registry. Using Cox regression, HRs were estimated for the incidence of MM. Adjustments for occupational and familial asbestos exposure were made with a job exposure matrix. An SIR analysis including latency periods testing the cancer incidence rate was performed with the comparison cohort as the reference rate. RESULTS: The median person-years of follow-up were 62.5 years in the school cohort and 62.2 years in the comparison cohort. There were 32 males and 6 females of the former pupils who developed MM during the follow-up: HRmale 7.01 (95% CI 4.24 to 11.57), HRfemale 7.43 (95% CI 2.50 to 22.13). Those who attended school 250 m north of the plant had the highest HR for MM, 10.65 (95% Cl 5.82 to 19.48). No significant trend between school distance and risk of MM was established (p=0.35). CONCLUSION: Our results suggest that boys and girls who attended schools and lived in the neighbourhood of an asbestos cement plant later in life have a significantly increased risk of MM.


Asunto(s)
Asbestos/efectos adversos , Mesotelioma/etiología , Medición de Riesgo/métodos , Anciano , Estudios de Cohortes , Dinamarca/epidemiología , Exposición a Riesgos Ambientales/efectos adversos , Exposición a Riesgos Ambientales/estadística & datos numéricos , Femenino , Estudios de Seguimiento , Humanos , Masculino , Mesotelioma/epidemiología , Metalurgia/estadística & datos numéricos , Persona de Mediana Edad , Sistema de Registros/estadística & datos numéricos
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