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1.
Zootaxa ; 5154(3): 355-364, 2022 Jun 15.
Artículo en Inglés | MEDLINE | ID: mdl-36095616

RESUMEN

Thick-thumbed bats of the genus Glischropus are currently composed of four recognized species from Southeast Asia, two of which were described in recent times. Among these species, G. aquilus is endemic to Sumatra, G. javanus is restricted to western Java, whereas G. bucephalus is widely distributed north to the Isthmus of Kra and G. tylopus is widespread south to this zoogeographic boundary. Two recently collected Glischropus specimens from Meghalaya state in north-eastern India extend the known distribution range of the genus westward into South Asia by ca. 1000 km. Morphological examination of these specimens and comparison with all known species in this genus revealed marked differences in colouration, dental characters and bacular traits. We therefore describe the Meghalaya specimens as a new species. The discovery of the new species from a forest patch adjacent to Nongkhyllem Wildlife Sanctuary from where another specialized bamboo-dwelling species (Eudiscopus denticulus) was reported recently also underscore the importance of the area from a conservation point of view.


Asunto(s)
Quirópteros , Animales , Asia Sudoriental , India
3.
Zootaxa ; 5182(1): 93-100, 2022 Sep 02.
Artículo en Inglés | MEDLINE | ID: mdl-36095696

RESUMEN

Three species of the genus Trachyphloeosoma Wollaston are described, illustrated and compared with related species: T. ales spec. n. from Taiwan, T. david spec. n. from China, Fujian province and T. philippinense spec. n. from the Philippines.


Asunto(s)
Escarabajos , Gorgojos , Animales , Asia Sudoriental , Filipinas
4.
BMC Ecol Evol ; 22(1): 110, 2022 Sep 20.
Artículo en Inglés | MEDLINE | ID: mdl-36127636

RESUMEN

The banteng (Bos javanicus) is an endangered species within the wild Asian Bos complex, that has traditionally been subdivided into three geographically isolated subspecies based on (i) mainland Southeast Asia (B. j. birmanicus), (ii) Java (B. j. javanicus), and (iii) Borneo (B. j. lowi). However, analysis of a single Bornean banteng mitochondrial genome generated through a genome skimming approach was used to suggest that it may actually represent a distinct species (Ishige et al. in Mitochondrial DNA A DNA Mapp Seq Anal 27(4):2453-4. http://doi.org/10.3109/19401736.2015.1033694 , 2016). To explore this hypothesis further, we leveraged on the GenBank (NCBI) raw read sequencing data originally used to construct the mitochondrial genome and reconstructed its nuclear genome at low (0.2×) coverage. When analysed in the context of nuclear genomic data representing a broad reference panel of Asian Bos species, we find the Bornean banteng affiliates strongly with the Javan banteng, in contradiction to the expectation if the separate species hypothesis was correct. Thus, despite the Bornean banteng's unusual mitochondrial lineage, we argue there is no genomic evidence that the Bornean banteng is a distinct species.


Asunto(s)
Genoma Mitocondrial , Genómica , Animales , Asia Sudoriental , Borneo , Bovinos , Genoma Mitocondrial/genética
5.
PLoS One ; 17(9): e0274433, 2022.
Artículo en Inglés | MEDLINE | ID: mdl-36107927

RESUMEN

Smoke haze due to vegetation and peatland fires in Southeast Asia is a serious public health concern. Several approaches have been applied in previous studies; however, the concepts and interpretations of these approaches are poorly understood. In this scoping review, we addressed issues related to the application of epidemiology (EPI), health burden estimation (HBE), and health risk assessment (HRA) approaches, and discussed the interpretation of findings, and current research gaps. Most studies reported an air quality index exceeding the 'unhealthy' level, especially during smoke haze periods. Although smoke haze is a regional issue in Southeast Asia, studies on its related health effects have only been reported from several countries in the region. Each approach revealed increased health effects in a distinct manner: EPI studies reported excess mortality and morbidity during smoke haze compared to non-smoke haze periods; HBE studies estimated approximately 100,000 deaths attributable to smoke haze in the entire Southeast Asia considering all-cause mortality and all age groups, which ranged from 1,064-260,000 for specified mortality cause, age group, study area, and study period; HRA studies quantified potential lifetime cancer and non-cancer risks due to exposure to smoke-related chemicals. Currently, there is a lack of interconnection between these three approaches. The EPI approach requires extensive effort to investigate lifetime health effects, whereas the HRA approach needs to clarify the assumptions in exposure assessments to estimate lifetime health risks. The HBE approach allows the presentation of health impact in different scenarios, however, the risk functions used are derived from EPI studies from other regions. Two recent studies applied a combination of the EPI and HBE approaches to address uncertainty issues due to the selection of risk functions. In conclusion, all approaches revealed potential health risks due to smoke haze. Nonetheless, future studies should consider comparable exposure assessments to allow the integration of the three approaches.


Asunto(s)
Contaminantes Atmosféricos , Incendios , Contaminantes Atmosféricos/análisis , Contaminantes Atmosféricos/toxicidad , Asia Sudoriental/epidemiología , Salud Pública , Medición de Riesgo
6.
Proc Natl Acad Sci U S A ; 119(39): e2112341119, 2022 Sep 27.
Artículo en Inglés | MEDLINE | ID: mdl-36122224

RESUMEN

Urbanization is rapidly transforming much of Southeast Asia, altering the structure and function of the landscape, as well as the frequency and intensity of the interactions between people, animals, and the environment. In this study, we explored the impact of urbanization on zoonotic disease risk by simultaneously characterizing changes in the ecology of animal reservoirs (rodents), ectoparasite vectors (ticks), and pathogens across a gradient of urbanization in Kuching, a city in Malaysian Borneo. We sampled 863 rodents across rural, developing, and urban locations and found that rodent species diversity decreased with increasing urbanization-from 10 species in the rural location to 4 in the rural location. Notably, two species appeared to thrive in urban areas, as follows: the invasive urban exploiter Rattus rattus (n = 375) and the native urban adapter Sundamys muelleri (n = 331). R. rattus was strongly associated with built infrastructure across the gradient and carried a high diversity of pathogens, including multihost zoonoses capable of environmental transmission (e.g., Leptospira spp.). In contrast, S. muelleri was restricted to green patches where it was found at high densities and was strongly associated with the presence of ticks, including the medically important genera Amblyomma, Haemaphysalis, and Ixodes. Our analyses reveal that zoonotic disease risk is elevated and heterogeneously distributed in urban environments and highlight the potential for targeted risk reduction through pest management and public health messaging.


Asunto(s)
Garrapatas , Urbanización , Animales , Asia Sudoriental , Ciudades , Humanos , Murinae , Ratas , Zoonosis/epidemiología
7.
Microb Pathog ; 170: 105693, 2022 Sep.
Artículo en Inglés | MEDLINE | ID: mdl-35940443

RESUMEN

Nipah virus (NiV), an emerging zoonotic virus, has been associated with several outbreaks with high death rates, mainly in South and Southeast Asia. NiV is responsible for Encephalitis and systemic vasculitis, and occasionally respiratory diseases accompanied by it. Though fruit bats are the natural source of NiV, it can be transmitted in a zoonotic manner directly or via an intermediate host (e.g., a pig or horse). Several studies explore the viral mechanism of disease progressions and its overall pathogenesis. However, understanding the pathogenesis and disease dynamics is necessary to develop therapeutic options and vaccines. Thus, in this review, we provide a comprehensive update on the emerging understanding of the pathogenesis of NiV.


Asunto(s)
Quirópteros , Infecciones por Henipavirus , Virus Nipah , Animales , Asia Sudoriental , Brotes de Enfermedades , Infecciones por Henipavirus/epidemiología , Caballos , Porcinos
8.
Toxins (Basel) ; 14(8)2022 08 19.
Artículo en Inglés | MEDLINE | ID: mdl-36006229

RESUMEN

Raw feed materials are often contaminated with mycotoxins, and co-occurrence of mycotoxins occurs frequently. A total of 250 samples i.e., rice bran and maize from Cambodia, Laos, Myanmar, and Thailand were analysed using state-of-the-art liquid chromatography-mass spectrometry (LC-MS/MS) for monitoring the occurrence of regulated, emerging, and masked mycotoxins. Seven regulated mycotoxins - aflatoxins, ochratoxin A, fumonisin B1, deoxynivalenol, zearalenone, HT-2, and T-2 toxin were detected as well as some emerging mycotoxins, such as beauvericin, enniatin type B, stachybotrylactam, sterigmatocystin, and masked mycotoxins, specifically zearalenone-14-glucoside, and zearalenone-16-glucoside. Aspergillus and Fusarium mycotoxins were the most prevalent compounds identified, especially aflatoxins and fumonisin B1 in 100% and 95% of samples, respectively. Of the emerging toxins, beauvericin and enniatin type B showed high occurrences, with more than 90% of rice bran and maize contaminated, whereas zearalenone-14-glucoside and zearalenone-16-glucoside were found in rice bran in the range of 56-60%. Regulated mycotoxins (DON and ZEN) were the most frequent mycotoxin combination with emerging mycotoxins (BEA and ENN type B) in rice bran and maize. This study indicates that mycotoxin occurrence and co-occurrence are common in raw feed materials, and it is critical to monitor mycotoxin levels in ASEAN's feedstuffs so that mitigation strategies can be developed and implemented.


Asunto(s)
Aflatoxinas , Micotoxinas , Oryza , Zearalenona , Aflatoxinas/análisis , Asia Sudoriental , Cromatografía Liquida/métodos , Contaminación de Alimentos/análisis , Glucósidos , Micotoxinas Enmascaradas , Micotoxinas/análisis , Espectrometría de Masas en Tándem/métodos , Zea mays , Zearalenona/análisis
9.
Nat Commun ; 13(1): 4955, 2022 08 24.
Artículo en Inglés | MEDLINE | ID: mdl-36002452

RESUMEN

Most intensive human activities occur in lowlands. However, sporadic reports indicate that human activities are expanding in some Asian highlands. Here we investigate the expansions of human activities in highlands and their effects over Asia from 2000 to 2020 by combining earth observation data and socioeconomic data. We find that ∼23% of human activity expansions occur in Asian highlands and ∼76% of these expansions in highlands comes from ecological lands, reaching 95% in Southeast Asia. The expansions of human activities in highlands intensify habitat fragmentation and result in large ecological costs in low and lower-middle income countries, and they also support Asian developments. We estimate that cultivated land net growth in the Asian highlands contributed approximately 54% in preventing the net loss of the total cultivated land. Moreover, the growth of highland artificial surfaces may provide living and working spaces for ∼40 million people. Our findings suggest that highland developments hold dual effects and provide new insight for regional sustainable developments.


Asunto(s)
Asiáticos , Ecosistema , Asia , Asia Sudoriental , Humanos
11.
Environ Sci Technol ; 56(18): 13284-13293, 2022 Sep 20.
Artículo en Inglés | MEDLINE | ID: mdl-36040952

RESUMEN

Land use change (LUC) induced by biofuel production could lead to greenhouse gas (GHG) emissions, which potentially increase biofuel's carbon intensity. Among the sources of LUC-related emissions for soy biodiesel, the contribution from peatland loss to agricultural plantations in Southeast Asia remains uncertain. Here, we analyzed LUC in Malaysia and Indonesia and modeled its impacts on the GHG emissions of soy biodiesel produced in the United States. It shows that oil palm plantations have more than doubled over 2001-2016 and the area of palm-on-peatlands (PoP) has expanded 3.7 times. Over new palm plantations, the share of PoP is about 19% regardless of time and location and the emission factor (EF) for peatland-to-palm conversion is estimated to be 41.5 Mg CO2 ha-1 yr-1. With these updates on PoP and EF, the contribution of peatland loss (0.7-5.1 g CO2e MJ-1) to biodiesel emissions is only 40-65% of previous estimates, which reduces discrepancies among model simulations used by different agencies. Based on emerging evidence on LUC and related carbon changes, our analysis reexamines regional peatland loss and its impacts on LUC emissions modeling and provides new insights into the estimation of LUC impacts on biofuels' carbon intensity.


Asunto(s)
Gases de Efecto Invernadero , Asia Sudoriental , Biocombustibles , Carbono , Dióxido de Carbono/análisis , Estados Unidos
12.
Sci Rep ; 12(1): 13805, 2022 Aug 13.
Artículo en Inglés | MEDLINE | ID: mdl-35963964

RESUMEN

Building energy intensity (BEI) has been used to assess a building's overall energy performance. However, the energy performance, CO2 footprint and electricity costs due to lighting in buildings are currently required to assist relevant authorities to develop, revise and implement energy-efficient lighting policies that are effective and acceptable for the country. This work presents an estimation approach for lighting in commercial buildings in Southeast Asia and its decarbonisation pathway for benchmarking. Application of this approach to a selected library in Brunei Darussalam showed that an energy-efficient light-emitting diode (LED) lighting system would make the building greener. We projected reductions in lighting energy consumption by 6.7 times (3.98 kWh/m2/year), its associated CO2 emissions by 8 times (0.59 kg CO2/m2/year) and electricity costs by 8.7 times (B$7.07/m2/year) by 2050 if existing lamps in the library are retrofitted with LED lamps.


Asunto(s)
Dióxido de Carbono , Iluminación , Asia Sudoriental , Dióxido de Carbono/análisis , Costos y Análisis de Costo , Electricidad
13.
Singapore Med J ; 63(5): 268-273, 2022 May.
Artículo en Inglés | MEDLINE | ID: mdl-36043277

RESUMEN

INTRODUCTION: Transcatheter aortic valve implantation (TAVI) is increasingly performed in patients with severe aortic stenosis. A novel dual-filter system to reduce cerebral embolism during TAVI recently became available. We aimed to assess the feasibility, safety, and clinical and neurocognitive outcomes of TAVI with cerebral protection in Asian patients. METHODS: 40 consecutive patients undergoing TAVI with cerebral protection were enrolled. All procedures were performed via femoral access using the self-expanding Evolut R/PRO or Portico, or the balloon-expandable SAPIEN 3 bioprostheses. Baseline characteristics, procedural and clinical outcomes were recorded. Cognition was assessed at baseline and 30 days using the abbreviated mental test (AMT). RESULTS: The mean age of the patients (75% male) was 76.4 ± 8.4 years. TAVI was uncomplicated in all patients. The filter device was successfully deployed in 38 (95.0%) patients without safety issues. There was no stroke or death at 30 days, and the survival rate at nine months was 95.0%. There was no overall cognitive change (baseline vs. 30-day AMT: 9.2 ± 1.1 vs. 9.0 ± 1.5, p = 0.12), and only 1 (2.5%) patient developed impaired cognition at 30 days. Patients with a decreased AMT score at 30 days were significantly older than those without (82.1 ± 4.5 vs. 74.4 ± 7.7 years, p = 0.019). All patients with decreased AMT scores were aged ≥ 76 years. CONCLUSION: In this early Asian experience of TAVI under cerebral protection, the filter device was successfully deployed in 95% of patients, with 100% procedural success. There were no filter-related complications and no stroke or mortality at 30 days. Overall cognition was preserved, although increased age was associated with a decline in AMT score.


Asunto(s)
Estenosis de la Válvula Aórtica , Prótesis Valvulares Cardíacas , Accidente Cerebrovascular , Reemplazo de la Válvula Aórtica Transcatéter , Anciano , Anciano de 80 o más Años , Válvula Aórtica/cirugía , Estenosis de la Válvula Aórtica/cirugía , Asia Sudoriental , Femenino , Prótesis Valvulares Cardíacas/efectos adversos , Humanos , Masculino , Diseño de Prótesis , Accidente Cerebrovascular/etiología , Accidente Cerebrovascular/prevención & control , Reemplazo de la Válvula Aórtica Transcatéter/efectos adversos , Reemplazo de la Válvula Aórtica Transcatéter/métodos , Resultado del Tratamiento
14.
PLoS One ; 17(8): e0272966, 2022.
Artículo en Inglés | MEDLINE | ID: mdl-36037160

RESUMEN

Species of colourful arboreal snails of the genus Amphidromus from Southeast Asia commonly exhibit high intraspecific variation in shell morphology. Although highly polymorphic Amphidromus specimens with different colouration have been collected at the same locality and were revealed to possess similar genital organs, there is yet no morphometric or DNA analyses of these different shell morphs. This study is the first to reveal that both striped and stripeless morphs of A. cruentatus from Laos and Vietnam belong to the same mitochondrial (COI and 16S rRNA) lineage. Although the shell colouration between the striped and stripeless morphs is markedly different, morphometric and shell outline-based analyses indicated an overall similarity in shell shape. We also revised the systematics of A. cruentatus, in which we treated similar related species, namely A. eudeli, A. fuscolabris, A. thakhekensis, A. gerberi bolovenensis, A. goldbergi, A. pengzhuoani, A. eichhorsti and A. pankowskiae as junior synonyms of A. cruentatus. Amphidromus daoae, A. anhdaoorum, A. stungtrengensis, A. yangbayensis and A. yenlinhae, which were formerly regarded as junior synonyms, are considered as species different from A. cruentatus based on shell morphology and morphometric analyses. Preliminary phylogenetic analyses also retrieved some Amphidromus species groups as distinct mitochondrial lineages.


Asunto(s)
Polimorfismo Genético , Caracoles , Animales , Asia Sudoriental , Filogenia , ARN Ribosómico 16S/genética
15.
Diabetes Metab Syndr ; 16(8): 102583, 2022 Aug.
Artículo en Inglés | MEDLINE | ID: mdl-35952510

RESUMEN

BACKGROUND: The growing prevalence of lipid disorder in Southeast Asia (SEA) resulted in an increase in clinical and epidemiological studies on dyslipidemia in the region. Thus, there is a need to summarize the existing evidence from the literature. AIMS: This paper determined the research landscape of dyslipidemia in SEA. This study also identified the socioeconomic facilitators of scientific productivity in dyslipidemia research in SEA. METHODS: A database search of dyslipidemia literature in SEA countries was performed using the Scopus database. Bibliographic information was obtained, and network visualization of collaboration among countries and keywords was created using VOSviewer software. RESULTS: This bibliometric analysis showed a continuous increase in published articles in SEA, most of which were from universities and hospitals in Thailand, Singapore, Malaysia, and Indonesia. The usual topics of dyslipidemia research in SEA include epidemiology, pathophysiology, comorbidities and complications, and treatment options for dyslipidemia. Research & development expenditure (total citations: p = 0.037; h-index: p = 0.031) and researchers in R&D (total citations: p = 0.005; h-index: p = 0.017) were positively correlated with citations and h-index for dyslipidemia publications from SEA countries. Moreover, the number of research collaborations within SEA and worldwide was positively correlated with the total publications, citations, and h-index of SEA countries for their dyslipidemia research outputs. CONCLUSION: In summary, this bibliometrics study showed an increasing trend of dyslipidemia research in SEA countries. Policymakers and administrators should invest more in dyslipidemia studies to propose better strategies in curbing the prevalence of this condition in SEA.


Asunto(s)
Investigación Biomédica , Dislipidemias , Asia Sudoriental , Bibliometría , Humanos , Factores Socioeconómicos
16.
Front Public Health ; 10: 910055, 2022.
Artículo en Inglés | MEDLINE | ID: mdl-35991011

RESUMEN

Applications of systems thinking in the context of Health Policy and Systems Research have been scarce, particularly in Low- and Middle-Income Countries (LMICs). Given the urgent need for addressing implementation challenges, the WHO Alliance for Health Policy and Systems Research, in collaboration with partners across five global regions, recently initiated a global community of practice for applied systems thinking in policy and practice contexts within LMICs. Individual one on one calls were conducted with 56 researchers, practitioners & decision-makers across 9 countries in Southeast Asia to elucidate key barriers and opportunities for applying systems thinking in individual country settings. Consultations presented the potential for collaboration and co-production of knowledge across diverse stakeholders to strengthen opportunities by applying systems thinking tools in practice. While regional nuances warrant further exploration, there is a clear indication that policy documentation relevant to health systems will be instrumental in advancing a shared vision and interest in strengthening capacities for applied systems thinking in health systems across Southeast Asia.


Asunto(s)
Política de Salud , Investigación sobre Servicios de Salud , Asia Sudoriental , Humanos , Pobreza , Investigadores
17.
Front Public Health ; 10: 863323, 2022.
Artículo en Inglés | MEDLINE | ID: mdl-35991032

RESUMEN

Mental health has become a growing concern in the wake of the COVID-19 pandemic. We sought to determine the prevalence of mental health symptoms 18 months after the pandemic's declaration. Our cross-sectional study conducted among 18- to 65-year-old adults (N = 33,454) in October 2021 using the Depression, Anxiety and Stress Scales (DASS-21) found a high prevalence of severe to extremely severe anxiety (49%), depression (47%) and stress (36%) symptoms in Malaysia, Indonesia, Thailand, and Singapore. Multiple logistic regression showed that female and non-binary genders were associated with increased odds of severe/extremely severe symptoms of anxiety (female: aOR 1.44 [95% CI 1.37-1.52]; non-binary aOR 1.46 [1.16-1.84]), depression (female: aOR 1.39 [1.32-1.47]; non-binary aOR 1.42 [1.13-1.79]), and stress (female: aOR 1.48 [CI 1.40-1.57]; non-binary aOR 1.42 [1.12-1.78]). In all three symptom domains, the odds of severe/extremely severe symptoms decreased across age groups. Middle- and high-income respondents had lower odds of reporting severe/extremely severe anxiety (middle-income: aOR 0.79 [0.75-0.84]; high-income aOR 0.77 [0.69-0.86]) and depression (middle-income: aOR 0.85 [0.80-0.90]; high-income aOR 0.84 [0.76-0.94]) symptoms compared to low-income respondents, while only middle-income respondents had lower odds of experiencing severe/extremely severe stress symptoms (aOR 0.89 [0.84-0.95]). Compared to residents of Malaysia, residents of Indonesia were more likely to experience severe/extremely severe anxiety symptoms (aOR 1.08 [1.03-1.15]) but less likely to experience depression (aOR 0.69 [0.65-0.73]) or stress symptoms (aOR 0.92 [0.87-0.97]). Respondents living in Singapore had increased odds of reporting severe/extremely severe depression symptoms (aOR 1.33 [1.16-1.52]), while respondents residing in Thailand were more likely to experience severe/extremely severe stress symptoms (aOR 1.46 [1.37-1.55]). This study provides insights into the impacts of the COVID-19 pandemic on the point prevalence of psychological distress in Southeast Asia one and a half years after the beginning of the pandemic.


Asunto(s)
COVID-19 , Pandemias , Adolescente , Adulto , Anciano , Ansiedad/epidemiología , Asia Sudoriental/epidemiología , COVID-19/epidemiología , Estudios Transversales , Depresión/diagnóstico , Depresión/epidemiología , Femenino , Humanos , Masculino , Persona de Mediana Edad , Prevalencia , Adulto Joven
18.
Nat Commun ; 13(1): 4380, 2022 08 09.
Artículo en Inglés | MEDLINE | ID: mdl-35945197

RESUMEN

Emerging diseases caused by coronaviruses of likely bat origin (e.g., SARS, MERS, SADS, COVID-19) have disrupted global health and economies for two decades. Evidence suggests that some bat SARS-related coronaviruses (SARSr-CoVs) could infect people directly, and that their spillover is more frequent than previously recognized. Each zoonotic spillover of a novel virus represents an opportunity for evolutionary adaptation and further spread; therefore, quantifying the extent of this spillover may help target prevention programs. We derive current range distributions for known bat SARSr-CoV hosts and quantify their overlap with human populations. We then use probabilistic risk assessment and data on human-bat contact, human viral seroprevalence, and antibody duration to estimate that a median of 66,280 people (95% CI: 65,351-67,131) are infected with SARSr-CoVs annually in Southeast Asia. These data on the geography and scale of spillover can be used to target surveillance and prevention programs for potential future bat-CoV emergence.


Asunto(s)
COVID-19 , Quirópteros , Virus del SRAS , Animales , Asia Sudoriental/epidemiología , Evolución Molecular , Humanos , Filogenia , Estudios Seroepidemiológicos
19.
Syst Rev ; 11(1): 138, 2022 07 05.
Artículo en Inglés | MEDLINE | ID: mdl-35790977

RESUMEN

BACKGROUND: Fascioliasis is an emerging public health threat in a number of regions worldwide, including Southeast Asia. Up to now, a summary of current knowledge on the occurrence and the distribution in Southeast Asia is lacking. We therefore aim to gather recent information on the distribution and prevalence of and the associated risk factors for Fasciola spp. infections in humans, animals, and plant carriers in Southeast Asia. METHODS: Bibliographic and gray literature databases as well as reference lists of important review articles will be searched for relevant records that are published between January 1, 2000, and the search date. The systematic review will be reported according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines for reporting systematic reviews. The primary outcomes will be both the prevalence of Fasciola spp. in the human and animal hosts, and on plant carriers in Southeast Asia, and the risk factors for occurrence of Fasciola spp. Secondary outcomes are the prevalence of Fasciola spp. in subpopulations (e.g., children and patients visiting clinics), the mapping of different diagnostic tests used, and the occurrence of the different Fasciola spp. in the study region. A descriptive statistical analysis will be conducted, and a meta-analysis will be run to estimate the prevalence of human and animal fascioliasis respectively, in Southeast Asia. DISCUSSION: This systematic review will summarize the current knowledge on the epidemiology of Fasciola spp. infections in Southeast Asia. SYSTEMATIC REVIEW REGISTRATION: This systematic review has been registered with the International Prospective Register of Systematic Reviews (PROSPERO), reference number: CRD42021261104 .


Asunto(s)
Fasciola , Fascioliasis , Animales , Asia Sudoriental/epidemiología , Fascioliasis/epidemiología , Metaanálisis como Asunto , Prevalencia , Salud Pública , Revisiones Sistemáticas como Asunto
20.
Int J Infect Dis ; 122: 612-621, 2022 Sep.
Artículo en Inglés | MEDLINE | ID: mdl-35817284

RESUMEN

OBJECTIVE: In this study, we aimed to conduct a systematic review to characterize antimicrobial resistance (AMR) patterns for bacterial causes of febrile illness in Africa and Asia. METHODS: We included published literature from 1980-2015 based on data extracted from two recent systematic reviews of nonmalarial febrile illness from Africa, South Asia, and Southeast Asia. Selection criteria included articles with full bacterial identification and antimicrobial susceptibility testing (AST) results for key normally sterile site pathogen-drug combinations. Pooled proportions of resistant isolates were combined using random effects meta-analysis. Study data quality was graded using the Microbiology Investigation Criteria for Reporting Objectively (MICRO) framework. RESULTS: Of 3475 unique articles included in the previous reviews, 371 included the target pathogen-drug combinations. Salmonella enterica tested against ceftriaxone and ciprofloxacin were the two highest reported combinations (30,509 and 22,056 isolates, respectively). Pooled proportions of resistant isolates were high for third-generation cephalosporins for Klebsiella pneumoniae and Escherichia coli in all regions. The MICRO grading showed an overall lack of standardization. CONCLUSION: This review highlights a general increase in AMR reporting and in resistance over time. However, there were substantial problems with diagnostic microbiological data quality. Urgent strengthening of laboratory capacity, standardized testing, and reporting of AST results is required to improve AMR surveillance.


Asunto(s)
Antibacterianos , Farmacorresistencia Bacteriana , África/epidemiología , Antibacterianos/farmacología , Antibacterianos/uso terapéutico , Asia Sudoriental/epidemiología , Bacterias , Escherichia coli , Humanos
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