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1.
J Ethnopharmacol ; 282: 114574, 2022 Jan 10.
Artículo en Inglés | MEDLINE | ID: mdl-34461187

RESUMEN

ETHNOPHARMACOLOGICAL RELEVANCE: Gekko gecko is used as a traditional medicine for various diseases including respiratory disorders in northeast Asian countries, mainly Korea, Japan, and China. AIM OF THE STUDY: Allergic asthma is a chronic respiratory disease caused by an inappropriate immune response. Due to the recent spread of coronavirus disease 2019, interest in the treatment of pulmonary disorders has rapidly increased. In this study, we investigated the anti-asthmatic effects of G. gecko extract (GGE) using an established mouse model of ovalbumin-induced asthma. MATERIALS AND METHODS: To evaluate the anti-asthmatic effects of GGE, we evaluated histological changes and the responses of inflammatory mediators related to allergic airway inflammation. Furthermore, we investigated the regulatory effects of GGE on type 2 helper T (Th2) cell activation. RESULTS: Administration of GGE attenuated asthmatic phenotypes, including inflammatory cell infiltration, mucus production, and expression of Th2 cytokines. Furthermore, GGE treatment reduced Th2 cell activation and differentiation. CONCLUSIONS: These results indicate that GGE alleviates allergic airway inflammation by regulating Th2 cell activation and differentiation.


Asunto(s)
Antiasmáticos/uso terapéutico , Asma/tratamiento farmacológico , Medicina Tradicional de Asia Oriental , Moco/metabolismo , Ovalbúmina , Extractos Vegetales/uso terapéutico , Animales , Asma/inducido químicamente , Asma/patología , Líquido del Lavado Bronquioalveolar , COVID-19 , Citocinas/metabolismo , Femenino , Citometría de Flujo , Inmunoglobulina E/inmunología , Mediadores de Inflamación/metabolismo , Pulmón/patología , Ratones , Ratones Endogámicos BALB C , Pandemias , Células Th2/efectos de los fármacos , Células Th2/inmunología , Triptaminas/farmacología
2.
Georgian Med News ; (318): 105-109, 2021 Sep.
Artículo en Inglés | MEDLINE | ID: mdl-34628388

RESUMEN

Western countries have been challenged with an "allergy epidemic" during the last three to four decades. Interestingly, there has been a parallel increase in the incidence rates of several autoimmune disorders.The aim of our study was to evaluate antinuclear antibodies (ANA) in Georgian allergic patientspolysensitized with cross reactive allergens, in order to establish connection between allergic and autoimmune diseases in our population. Two groups of patients were included in the study: patients with atopy (group 1, n=97) and without (group 2, n=42).ImmunoCAPPhadiatop and ISAC assay platforms were used for atopy screening and polysensitization patterns evaluation. Screening for ANAs was performed by IIFA (Indirect Immunofluorescence assay) on HEp-2 cells. In general 67(69.1%) allergic patients were sensitized to at least one of the cross reactive allergen. Among allergic patients 26 (26.8%) tested positive for the presence of auto-antibodies; for non-allergic patient this value was only 1(2.4%). 18(26.9%) patients sensitized to cross reactive allergens showed positive results for ANA testing and 8(26.7%) allergic patient without cross allergen sensitization were positive for ANA. The AC-2 was only one detected pattern among non-atopic individuals (1/2.4%) and the most frequent pattern in allergic patients (19/73%). In the ANA positive group of allergic patients the atopic dermatitis (13/50%) and asthma (6/23.1%) were most frequently diagnosed. The occurrence of antinuclear antibodies is more frequent in atopic patients and associate mostly with asthma and atopic dermatitis phenotypes of allergic diseases. The most frequent coexisting ANA pattern is dense fine speckled pattern (AC-2).The occurrence of ANA antibody in atopic patients and its role in allergy remains the subject for future research.


Asunto(s)
Asma , Dermatitis Atópica , Hipersensibilidad , Alérgenos , Anticuerpos Antinucleares , Humanos , Hipersensibilidad/epidemiología
3.
Rev Med Liege ; 76(10): 768-772, 2021 Oct.
Artículo en Francés | MEDLINE | ID: mdl-34632748

RESUMEN

Here we present pharmacological and clinical properties of a new fixed triple inhaled combination including an inhaled corticoid, a long acting ?2 agonist and a long acting anticholinergic for the treatment of severe asthma. Enerzair® is the name of this triple combination which contains 160 µg mometasone, 150 µg indacaterol and 50 µg glycopyrronium administered by a Breezhaler®. As compared to an ICS/LABA combination Enerzair® improves expiratory flow rates and reduces exacerbation rate. The Breezhaler® device may be coupled to a sensor (Propeller Health) that, through a bluetooth system, allows to control patient adherence and provides recall to the patient to take his aerosol.


Asunto(s)
Asma , Enfermedad Pulmonar Obstructiva Crónica , Administración por Inhalación , Asma/tratamiento farmacológico , Glicopirrolato , Humanos , Indanos , Furoato de Mometasona/uso terapéutico , Enfermedad Pulmonar Obstructiva Crónica/tratamiento farmacológico , Quinolonas
4.
Medicine (Baltimore) ; 100(39): e27314, 2021 Oct 01.
Artículo en Inglés | MEDLINE | ID: mdl-34596130

RESUMEN

ABSTRACT: This study aimed to evaluate the correlation between fractional exhaled nitric oxide (FeNO) and nasal nitric oxide (nNO) in allergic rhinitis (AR) and patients with or without bronchial asthma (BA).A total of 90 patients who were diagnosed with persistent AR (AR group, n = 30), BA (BA group, n = 30), or allergic rhinitis with bronchial asthma (AR-BA) (AR-BA group, n = 30), were enrolled in this study, along with 30 healthy adult volunteers (control group, n = 30). The participants were further divided into 2 groups based on the results of a skin-prick test (SPT): a highly atopic group (SPT = 3+ and above) and a moderately atopic group (SPT = 2+ and below). All participants underwent FeNO and nNO measurement, an absolute blood eosinophil count, total serum immunoglobulin measurement, and horizontal baseline lung capacity determination.The results showed that the FeNO levels in the 3 observation groups were significantly higher than those in the control group (P < .01), and in the BA group they were significantly higher than in the AR-BA group (P < .01). The levels of nNO in both the AR group and the AR-BA group were higher than those in the control group and the BA group (P < .01), but there was no significant difference between the AR group and the AR-BA group (P > .05). The levels of nNO in the BA group were also significantly different from those in the control group (P < .01).FeNO and nNO are positively correlated with the degree of AR in patients with BA; therefore, nNO levels can be used as an inflammatory marker of AR in patients with BA. FeNO can also be used as an inflammatory marker of AR in patients complicated with BA as a warning indicator of asthma.


Asunto(s)
Asma/epidemiología , Asma/patología , Óxido Nítrico/análisis , Nariz/patología , Rinitis Alérgica/epidemiología , Rinitis Alérgica/patología , Adolescente , Adulto , Anciano , Eosinófilos/metabolismo , Espiración , Femenino , Humanos , Inmunoglobulina E/sangre , Masculino , Persona de Mediana Edad , Pruebas de Función Respiratoria , Adulto Joven
6.
Sichuan Da Xue Xue Bao Yi Xue Ban ; 52(5): 725-728, 2021 Sep.
Artículo en Chino | MEDLINE | ID: mdl-34622583

RESUMEN

Over the last decades, the overall prevalence of childhood asthma in China has been on the rise, and the level of diagnosis and treatment of asthma has also shown significant improvement. However, the overall control of childhood asthma in China has not yet reached the ideal level. The main causes are as follows: due to high social pressure and other factors, the accurate diagnosis of childhood asthma by clinicians is still insufficient; clinicians do not have sufficient understanding of environmental pollution and other controllable factors that may affect the rising prevalence of childhood asthma and poor asthma control; the standardization of clinical asthma treatment needs to be further improved. Clinicians should improve their understanding of childhood asthma, formulate therapeutic regimes based on the guidelines, and constantly improve the management of childhood asthma.


Asunto(s)
Asma , Asma/diagnóstico , Asma/epidemiología , Asma/terapia , China/epidemiología , Humanos , Prevalencia
7.
Sichuan Da Xue Xue Bao Yi Xue Ban ; 52(5): 832-838, 2021 Sep.
Artículo en Chino | MEDLINE | ID: mdl-34622601

RESUMEN

Objective: To study the distributional characteristics of allergens in children with allergic diseases in Shaanxi province. Methods: A total of 4 622 children diagnosed with allergic diseases in the Asthma Center, Department of Pediatrics, Xijing Hospital from March 2015 to February 2019 were selected. Serum allergen-specific immunoglobulin E (sIgE) of 19 common kinds of allergens were examined with enzyme-linked immunosorbent assay (ELISA). The children were divided into different groups according to sex, age and geographical regions, and the distributional characteristics of allergens of the different groups were compared. Results: The overall positive rate for the 19 allergens of the 4 622 children was 62.8%. The ranking of the positive rates for individual allergens from high to low were as follows: 24.2% for milk, 18.0% for mold mix, 16.7% for dog dander, 16.4% for house dust mite, 11.7% for cat dander, 10.7% for cashew, 10.6% for weed pollen, 8.8% for egg white, 7.8% for house dust, 7.7% for tree pollen, 5.6% for amaranth, 4.9% for mulberry tree, 3.6% for mango, 3.2% for beef, 2.8% for cockroach, 2.1% for crab, 1.5% for shrimp, 0.8% for pineapple, and 0.3% for shellfish. Analysis based on sex showed that the allergen positive rates in boys were higher than those in girls. Analysis by age difference showed that generally the positive rates for inhaled allergens increased along with the increase in patient age, while the positive rates for ingested allergens decreased along with the increase in patient age. Analysis by geographical regions showed that the positive rate of house dust mite in the patients from the southern part of Shaanxi, the positive rate of weed pollen in the patients from the northern part of Shaanxi and the positive rates of milk and egg white in the patients from the central part of Shaanxi were higher than those in other areas. The cluster analysis and correlation analysis showed that the 19 allergens could be roughly divided into 4 categories. There were moderate correlations among tree pollen, mulberry tree and amaranth. There were moderate correlations among mulberry tree, mango and amaranth. There was moderate correlation between shrimp and crab, and there were mild or weak correlations among most of the other allergens. Conclusion: Among the 4 622 children with allergic diseases in Shaanxi Province who were treated in the Asthma Center, Department of Pediatrics, Xijing Hospital, male patients showed higher sensitivity to allergens. The positive rates of inhaled allergens increased, while the positive rates of ingested allergens decreased with increase in patient age. There were regional differences in the distribution of allergens. Some allergens were correlated with each other, which may be related to cross-reaction.


Asunto(s)
Asma , Hipersensibilidad , Alérgenos , Animales , Asma/epidemiología , Gatos , Bovinos , Niño , Perros , Polvo , Humanos , Inmunoglobulina E , Masculino
8.
Sichuan Da Xue Xue Bao Yi Xue Ban ; 52(5): 849-854, 2021 Sep.
Artículo en Chino | MEDLINE | ID: mdl-34622604

RESUMEN

Objective: To explore the clinical efficacy and influencing factors of children receiving mite-specific subcutaneous immunotherapy (SCIT). Methods: We retrospectively analyzed the data of children who had received mite SCIT for 3 years at the Desensitization Center of our hospital. We used the daily medication score (DMS) to evaluate the medication use status (the higher the score, the higher the amount of medications given and the less satisfactorily was the primary disease controlled) and we used the visual analogue scale (VAS) to evaluate clinical symptoms (the higher the score, the more severe the symptoms). Evaluation was performed after the first SCIT treatment and after treatment was given for 3 months, 4 months, 12 months, and 3 years. According to whether medication for the primary disease was stopped after 3 years, the patients were divided into two groups, the discontinued medication group (discontinued group) and the continued medication group (continued group). The general data, DMS, VAS and the decline rate of the two groups were compared, and logistic regression was performed to analyze the influencing factors of the outcome. Results: A total of 711 children were enrolled in the study, with an average age of 8.38 years at the time of the first visit to the hospital. There were 442 males and 269 females. Skin prick test showed that 445 cases only had mite allergy, and 266 cases had mite allergy combined with other allergies. 360 cases have discontinued the medication for the primary disease after 3 years, and 351 cases had relieved symptoms, but still needed to continue with the medication. At the beginning of SCIT treatment, the DMS and VAS of the discontinued group were lower than those of the continued group ( P<0.05). Evaluations from 3 months to 3 years showed that both DMS and VAS continued to decrease compared with those from the beginning, and the decline rate of DMS and VAS of the discontinued group was higher than that of the continued group after 3 years of SCIT ( P<0.05). After 3 months of SCIT, the positive rates of nasal and ocular symptoms in the discontinued group were lower than those in the continued group ( P<0.05). After 3 years of SCIT, the positive rates of nasal, ocular, and chest symptoms in the discontinued group were lower than those in the continued group ( P<0.05). Univariate analysis combined with multivariate logistic regression showed that initial DMS>4 points and initial VAS>3.5 points were protective factors for the discontinuation of the medication for the primary disease at the end of 3 years of SCIT, while the female sex and DMS reduction rate after 12 months of treatment>50% were risk factors for discontinuation. Conclusions: Mite SCIT can help relieve clinical symptoms and reduce the use of medication for symptomatic treatment. Symptoms can be improved after 3 months of SCIT, with the fastest improvement shown in nasal and eye symptoms. It is not recommended to discontinue the medication for the primary disease for too much after 1 year of treatment.


Asunto(s)
Asma , Ácaros , Animales , Niño , Femenino , Humanos , Inmunoterapia , Inyecciones Subcutáneas , Masculino , Estudios Retrospectivos
9.
J Assoc Physicians India ; 69(4): 11-12, 2021 Apr.
Artículo en Inglés | MEDLINE | ID: mdl-34470194

RESUMEN

For decades, short acting beta agonists (SABAs) have been prescribed for giving symptomatic relief to asthmatics. However, this symptomatic benefit perceived by the patient leads to the overuse and dependency of the patient to the SABA inhaler and underusage of the inhaled corticosteroid (ICS) containing controller inhalers resulting in destabilizing disease control and increased risk of exacerbations. In order to address this issue, the 2019 update of the Global Initiative for Asthma (GINA) strategy document no longer recommends the use of SABA inhalers as the preferred reliever for asthma due to concerns around poor outcomes and safety. Instead, it strongly supports the use of a combined ICS-fast acting beta agonist as a reliever also termed as an Anti-inflammatory Reliever Therapy (AIR). In this review we discuss the extent of SABA overusage and its impact on asthma outcomes, the resultant change in the recommendations in the GINA document and finally the evidence supporting the use of formoterol- budesonide as AIR therapy.


Asunto(s)
Antiasmáticos , Asma , Administración por Inhalación , Corticoesteroides , Antiasmáticos/uso terapéutico , Asma/tratamiento farmacológico , Budesonida/uso terapéutico , Combinación de Medicamentos , Etanolaminas/uso terapéutico , Fumarato de Formoterol/uso terapéutico , Humanos , Nebulizadores y Vaporizadores
10.
Sheng Wu Gong Cheng Xue Bao ; 37(8): 2870-2877, 2021 Aug 25.
Artículo en Chino | MEDLINE | ID: mdl-34472304

RESUMEN

Asthma is a common respiratory disease that affects 300 million of people worldwide, posing a serious health risk and medical burden. Development of new anti-asthmatic drugs and alternative treatment regimens is therefore encouraged. Recent studies have shown that Epidermal Growth Factor Receptor (EGFR) is involved in asthma development. In order to construct nanoparticles targeting EGFR for asthma treatment, a single chain antibody fragment (scFv) against EGFR was genetically engineered and modified at the N-terminal end of the human ferritin H-chain (FTH1) to construct Anti EGFR scFv::FTH1/FTH1 nanoparticles. Transmission electron microscopy showed that the nanoparticles were self-assembled into hollow cage-like structures with the particle size of about 12 nm. Semi-quantitative analysis of the purified nanoparticles by SDS-PAGE revealed the mass ratio of FTH1 to Anti EGFR scFv::FTH1 was 7:3. In House Dust Mite (HDM) driven models, Anti EGFR scFv::FTH1/FTH1 nanoparticles efficiently attenuated several key features of asthma, including goblet cell hyperplasia, mucous metaplasia and subepithelial fibrosis, showing the potential of using ferritin based nanoparticle for asthma treatment.


Asunto(s)
Asma , Nanopartículas , Anticuerpos de Cadena Única , Asma/tratamiento farmacológico , Ferritinas , Humanos , Oxidorreductasas , Anticuerpos de Cadena Única/genética
11.
Chin J Physiol ; 64(4): 177-185, 2021.
Artículo en Inglés | MEDLINE | ID: mdl-34472448

RESUMEN

Heart rate variability (HRV) and cardiorespiratory phase synchronization (CRPS) were employed to study the cardio- and respiratory interactions in patients with asthma receiving inhalation of beta2-agonist (Berotec 200 mcg) for routine bronchodilator test. Both time- and frequency-domain parameters were used to analyze the HRV. A weighted G-index was introduced to study the quality of the CRPS. The HRV parameters, in both the time and frequency domains, exhibited significant changes pointing to a sympathetic activation of the autonomic balance immediately after the inhalation. On the other hand, the CRPS index barely changed throughout the entire process. This indicates that inhalation of beta2-agonist does not alter the CRPS appreciably, and that the CRPS, in contrast to HRV, is relatively stable in response to the inhalation of beta2-agonist in patients with asthma.


Asunto(s)
Asma , Broncodilatadores , Asma/diagnóstico , Asma/tratamiento farmacológico , Sistema Nervioso Autónomo , Broncodilatadores/farmacología , Broncodilatadores/uso terapéutico , Corazón , Frecuencia Cardíaca , Humanos
12.
Zhongguo Zhong Yao Za Zhi ; 46(16): 4214-4221, 2021 Aug.
Artículo en Chino | MEDLINE | ID: mdl-34467735

RESUMEN

As recorded, agarwood has the function of improving qi reception and relieving asthma, but the underlying mechanism is unclear and rarely reported. Therefore, this study explored the anti-asthmatic effect of the alcohol extract of agarwood produced by the whole-tree agarwood-inducing technique(Agar-Wit) in the asthma mouse model induced by intraperitoneal injection of ovalbumin(OVA) + Al(OH)_3 combined with intranasal administration of OVA and the mechanism, and compared the anti-asthmatic effects of agarwood induced with different methods. Firstly, the anti-inflammatory and anti-asthmatic effects of Agar-Wit agarwood in mice were evaluated based on the asthma frequency, lung tissue injury, and peripheral inflammatory white blood cell(WBC) count and eosinophil count. Then, the levels of interleukin-1ß(IL-1ß), IL-17, and IL-10 in serum of mice were detected by enzyme-linked immunoassay(ELISA) and the expression of inflammation-and apoptosis-related genes in tissues was measured by reverse transcription polyme-rase chain reaction(RT-PCR) so as to preliminarily explore the anti-asthmatic mechanism. RESULTS:: showed that the alcohol extract of Agar-Wit agarwood significantly reduced asthma frequency, relieved pathological injury, improved peripheral WBC count and eosinophil count, decreased the levels of inflammatory cytokines IL-1ß and IL-17, elevated the level of anti-inflammatory cytokine IL-10, and down-regulated the mRNA expression of IL-1 R, tumor necrosis factor receptor R(TNFR), nuclear transcription factor-kappa B(NF-κB), Bax, and caspase 3, but had no significant influence on the expression of high-mobility group box 1(HMGB1) protein, caspase 8, and Bcl-2. The effect of Agar-Wit agarwood alcohol extract was better than that of wild agarwood alcohol extract and alcohol extract of agarwood induced with the burning-chisel-drilling method at the same dose. In conclusion, Agar-Wit agarwood can significantly alleviate inflammation and asthma, which is related to its anti-inflammation and anti-apoptosis activity.


Asunto(s)
Antiasmáticos , Asma , Animales , Asma/tratamiento farmacológico , Líquido del Lavado Bronquioalveolar , Modelos Animales de Enfermedad , Pulmón , Ratones , Ratones Endogámicos BALB C , FN-kappa B , Ovalbúmina , Extractos Vegetales/uso terapéutico
13.
J Hazard Mater ; 416: 125856, 2021 08 15.
Artículo en Inglés | MEDLINE | ID: mdl-34492805

RESUMEN

Inhalation of aerosols such as pharmaceutical aerosols or virus aerosol uptake is of great concern to the human population. To elucidate the underlying aerosol dynamics, the deposition fractions (DFs) of aerosols in healthy and asthmatic human airways of generations 13-15 are predicted. The Navier-stokes equations governing the gaseous phase and the discrete phase model for particles' motion are solved using numerical methods. The main forces responsible for deposition are inertial impaction forces and complex secondary flow velocities. The curvatures and sinusoidal folds in the asthmatic geometry lead to the formation of complex secondary flows and hence higher DFs. The intensities of complex secondary flows are strongest at the generations affected by asthma. The DF in the healthy airways is 0%, and it ranges from 1.69% to 52.93% in the asthmatic ones. From this study, the effects of the pharmaceutical aerosol particle diameters in the treatment of asthma patients can be established, which is conducive to inhibiting the inflammation of asthma airways. Furthermore, with the recent development of COVID-19 which causes pneumonia, the predicted physics and effective simulation methods of bioaerosols delivery to asthma patients are vital to prevent the exacerbation of the chronic ailment and the epidemic.


Asunto(s)
Asma , COVID-19 , Aerosoles , Asma/tratamiento farmacológico , Simulación por Computador , Humanos , Pulmón , Modelos Biológicos , Tamaño de la Partícula , SARS-CoV-2
14.
Rev Assoc Med Bras (1992) ; 67(4): 571-576, 2021 Apr.
Artículo en Inglés | MEDLINE | ID: mdl-34495063

RESUMEN

OBJECTIVE: The goals of this study are to compare self-reported depression and anxiety in subjects diagnosed of asthma and healthy controls. METHODS: We designed a case-control study. Subjects were recruited using a consecutive sampling method from a single institution. Two groups were created: Asthma and healthy controls. Data of medical history and demographic background were collected from the medical record. Self-reported depression level was assessed using Beck's depression inventory (BDI). Self-reported anxiety was measured with the "State-trait anxiety inventory" (STAI). RESULTS: Fifty-one subjects with asthma, and fifty healthy patients were included in this study. BDI scores (p<0.001) were higher for asthma (10.22±7.3) than in the control group (5.2±6.56). STAI state (p<0.001) was higher in asthma (42.61±11.5) than in controls (34.88±9.25). STAI trait (p<0.001) showed higher scores in asthma (43.14±10.89) than in controls (34.62±9.19). CONCLUSIONS: These study findings showed that BDI, and STAI trait and state scores are significantly higher in subjects who suffer from asthma than healthy controls.


Asunto(s)
Asma , Depresión , Ansiedad , Trastornos de Ansiedad , Estudios de Casos y Controles , Humanos
15.
Int J Mol Sci ; 22(17)2021 Aug 24.
Artículo en Inglés | MEDLINE | ID: mdl-34502019

RESUMEN

The lungs play a very important role in the human respiratory system. However, many factors can destroy the structure of the lung, causing several lung diseases and, often, serious damage to people's health. Nerve growth factor (NGF) is a polypeptide which is widely expressed in lung tissues. Under different microenvironments, NGF participates in the occurrence and development of lung diseases by changing protein expression levels and mediating cell function. In this review, we summarize the functions of NGF as well as some potential underlying mechanisms in pulmonary fibrosis (PF), coronavirus disease 2019 (COVID-19), pulmonary hypertension (PH), asthma, chronic obstructive pulmonary disease (COPD), and lung cancer. Furthermore, we highlight that anti-NGF may be used in future therapeutic strategies.


Asunto(s)
Remodelación de las Vías Aéreas (Respiratorias)/efectos de los fármacos , Pulmón/patología , Factor de Crecimiento Nervioso/antagonistas & inhibidores , Transducción de Señal/efectos de los fármacos , Asma/tratamiento farmacológico , Asma/patología , COVID-19/tratamiento farmacológico , COVID-19/patología , Humanos , Hipertensión Pulmonar/tratamiento farmacológico , Hipertensión Pulmonar/patología , Pulmón/efectos de los fármacos , Neoplasias Pulmonares/tratamiento farmacológico , Neoplasias Pulmonares/patología , Terapia Molecular Dirigida/métodos , Factor de Crecimiento Nervioso/metabolismo , Enfermedad Pulmonar Obstructiva Crónica/tratamiento farmacológico , Enfermedad Pulmonar Obstructiva Crónica/patología , Fibrosis Pulmonar/tratamiento farmacológico , Fibrosis Pulmonar/patología
17.
BMC Pulm Med ; 21(1): 278, 2021 Aug 31.
Artículo en Inglés | MEDLINE | ID: mdl-34465321

RESUMEN

BACKGROUND: There are various reasons for delayed positive nasopharyngeal PCR tests for coronavirus disease 2019 (COVID19) in not only asymptomatic but also severely diseased patients. The pathophysiological attributes are not known. We explore this possibility through a case report. CASE PRESENTATION: A 64-year-old male with history of pulmonary fungal infection, asthma and chronic pulmonary obstructive disease (COPD), diabetes, coronary artery disease presented with shortness of breath, fever and chest image of ground opacity, reticular interstitial thickening, highly suspicious for COVID19. However, nasopharyngeal swab tests were discordantly negative for four times in two weeks, and IgG antibody for COVID19 was also negative. However, serum IgE level was elevated. No other pathogens are identified. His symptoms deteriorated despite corticosteroid, antibiotics and bronchodilator treatment. Bronchoalveolar lavage (BAL) and open lung wedge biopsy were performed for etiology diagnosis. They demonstrated COVID19 viral RNA positive fibrosing organizing pneumonia with respiratory tract damage characterized by suspicious viral cytopathic effect, mixed neutrophilic, lymphoplasmacytic, histiocytic and eosinophilic inflammation and fibrosis besides expected asthma and COPD change. One week later, repeated COVID19 nasopharyngeal tests on day 40 and day 49 became positive. CONCLUSION: Our case and literature review indicate that allergic asthma and associated high IgE level together with corticosteroid inhalation might contribute to the delayed positive nasopharyngeal swab in upper airway; COPD related chronic airways obstruction and the addition of fibrosis induced ventilator dependence and poor prognosis in COVID19 pneumonia, and should be therapeutically targeted besides antiviral therapy.


Asunto(s)
Prueba de Ácido Nucleico para COVID-19 , COVID-19/diagnóstico , Diagnóstico Tardío , Nasofaringe/virología , SARS-CoV-2/aislamiento & purificación , Administración por Inhalación , Corticoesteroides/uso terapéutico , Asma/complicaciones , Asma/tratamiento farmacológico , Asma/patología , Lavado Broncoalveolar , COVID-19/complicaciones , COVID-19/terapia , Resultado Fatal , Humanos , Masculino , Persona de Mediana Edad , Enfermedad Pulmonar Obstructiva Crónica/complicaciones , Enfermedad Pulmonar Obstructiva Crónica/tratamiento farmacológico , Enfermedad Pulmonar Obstructiva Crónica/patología , Reacción en Cadena de la Polimerasa de Transcriptasa Inversa
18.
BMJ Open ; 11(9): e046769, 2021 09 02.
Artículo en Inglés | MEDLINE | ID: mdl-34475151

RESUMEN

OBJECTIVES: The association between hypertensive disorders in pregnancy (HDP) and an increased risk of asthma in offspring remains controversial. No systematic review of this topic has been performed. The aim of this systematic review was to summarise the available evidence regarding the association between HDP and the risk of asthma in offspring. DESIGN: Systematic review and meta-analysis. METHODS: On the basis of a prepared protocol, a systematic search of PubMed, EMBASE, the Cochrane Library and Web of Science was performed using a detailed search strategy from the database inception to 17 January 2020. Cohort, case-control and cross-sectional studies published in English reporting the diagnoses of maternal HDP and asthma in offspring were included. The Meta-analysis of Observational Studies in Epidemiology guidelines were followed throughout the study. The estimated pooled ORs of HDP and asthma in offspring were calculated from the studies, and the meta-analysis was performed using random-effects models. RESULTS: Ten cohort studies involving a total of 6 270 430 participants were included. According to the Newcastle-Ottawa Scale, the overall methodological quality was good since 8 studies were of high quality and 2 studies were of moderate quality. After controlling for potential confounders, HDP was associated with a possible increased risk of asthma in offspring, with a pooled adjusted OR (aOR) of 1.19 (95% CI 1.12 to 1.26). The subgroup analyses according to HDP subgroups, sibling design, study quality, study location, offspring ages, singleton status, exposure assessment, outcome assessment and adjusted factors showed similar results. CONCLUSIONS: Exposure to HDP may be associated with an increased risk of asthma in offspring. Further research is needed to verify the results and determine whether the observed relationship is causal. PROSPERO REGISTRATION NUMBER: CRD42020148250.


Asunto(s)
Asma , Hipertensión Inducida en el Embarazo , Preeclampsia , Asma/epidemiología , Asma/etiología , Estudios de Casos y Controles , Estudios Transversales , Femenino , Humanos , Hipertensión Inducida en el Embarazo/epidemiología , Embarazo
19.
Niger J Clin Pract ; 24(9): 1268-1276, 2021 Sep.
Artículo en Inglés | MEDLINE | ID: mdl-34531336

RESUMEN

Epidemiologic studies have reported increasing prevalence of childhood asthma in Nigeria and other developing countries where there are parallel increases in school enrolments. Children with asthma face lots of challenges in school which can affect their academic performance and quality of life. This narrative review highlights the challenges and the risks of schooling encountered by Nigerian children with asthma and the prospects of utilizing the School Health Programme (SHP) to overcome these challenges. An electronic search of relevant published articles from 2000 to 2020 was carried out using appropriate search engines for the following words: "schooling", "childhood asthma", "school health programme", "school environment," "health instructions", "school health services" and "asthma care in schools". The challenges and risks the school age asthmatics encounter in school include discrimination and victimization, exposure to triggers on the road and in the school environment, poor and non-existence asthma care services in schools, suboptimal knowledge of teachers and caregivers about childhood asthma hence poor asthma-related instructions and increased school absenteeism. The prospects of SHP as a tool to overcome these challenges are highlighted. These include the roles expected to be played by all stakeholders - the government and education authorities need to revise and more effectively implement the school health policy. The roles of asthma care professionals include the need to "adopt" schools to ensure optimal asthma care for the school population and the all-important enlightenment of teachers, school health workers, parents/caregivers and school children for overall improved asthma care delivery in Nigerian schools.


Asunto(s)
Asma , Calidad de Vida , Asma/epidemiología , Niño , Humanos , Nigeria/epidemiología , Servicios de Salud Escolar , Instituciones Académicas
20.
Zhongguo Dang Dai Er Ke Za Zhi ; 23(9): 877-881, 2021.
Artículo en Inglés, Chino | MEDLINE | ID: mdl-34535200

RESUMEN

OBJECTIVES: To study the efficacy of Huaiqihuang granules as adjuvant therapy for bronchial asthma in children. METHODS: A multicenter, prospective, and registered real-world study was performed for the children, aged 2-5 years, who had a confirmed diagnosis of bronchial asthma in the outpatient service of 21 hospitals in China. Among these children, the children treated with medications for long-term asthma control (inhaled corticosteroid and/or leukotriene receptor antagonist) without Huaiqihuang granules were enrolled as the control treatment group, and those treated with medications for long-term asthma control combined with Huaiqihuang granules were enrolled as the combined treatment group. The medical data of all children were collected. Outpatient or telephone follow-up was performed at weeks 4, 8, 12, 20, 28, and 36 after treatment, including asthma attacks and rhinitis symptoms. A statistical analysis was performed for the changes in these indices. RESULTS: There was no significant difference in the frequency of asthma attacks or rhinitis attacks between the two groups before treatment (P>0.05). After treatment, the combined treatment group had significantly lower frequencies of asthma attacks, severe asthma attacks, and rhinitis attacks compared with the control treatment group (P<0.05). There was no signification difference in the incidence rate of adverse reactions between the two groups (P=0.667). CONCLUSIONS: Huaiqihuang granules in addition to medications for long-term asthma control can alleviate the symptoms of bronchial asthma and rhinitis and improve the level of asthma control in children with bronchial asthma, with good safety and little adverse effect. Citation.


Asunto(s)
Asma , Medicamentos Herbarios Chinos , Asma/tratamiento farmacológico , Niño , Medicamentos Herbarios Chinos/uso terapéutico , Humanos , Estudios Prospectivos , Calidad de Vida
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