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1.
Cells ; 10(2)2021 02 02.
Artículo en Inglés | MEDLINE | ID: mdl-33540583

RESUMEN

Many viruses disrupt host gene expression by degrading host mRNAs and/or manipulating translation activities to create a cellular environment favorable for viral replication. Often, virus-induced suppression of host gene expression, including those involved in antiviral responses, contributes to viral pathogenicity. Accordingly, clarifying the mechanisms of virus-induced disruption of host gene expression is important for understanding virus-host cell interactions and virus pathogenesis. Three highly pathogenic human coronaviruses (CoVs), including severe acute respiratory syndrome (SARS)-CoV, Middle East respiratory syndrome (MERS)-CoV, and SARS-CoV-2, have emerged in the past two decades. All of them encode nonstructural protein 1 (nsp1) in their genomes. Nsp1 of SARS-CoV and MERS-CoV exhibit common biological functions for inducing endonucleolytic cleavage of host mRNAs and inhibition of host translation, while viral mRNAs evade the nsp1-induced mRNA cleavage. SARS-CoV nsp1 is a major pathogenic determinant for this virus, supporting the notion that a viral protein that suppresses host gene expression can be a virulence factor, and further suggesting the possibility that SARS-CoV-2 nsp1, which has high amino acid identity with SARS-CoV nsp1, may serve as a major virulence factor. This review summarizes the gene expression suppression functions of nsp1 of CoVs, with a primary focus on SARS-CoV nsp1 and MERS-CoV nsp1.


Asunto(s)
Betacoronavirus , Infecciones por Coronavirus/virología , Proteínas no Estructurales Virales/fisiología , Animales , Betacoronavirus/patogenicidad , Betacoronavirus/fisiología , Regulación de la Expresión Génica , Interacciones Microbiota-Huesped , Humanos , Ratones , ARN Mensajero/genética , Replicación Viral
2.
Washington; Organización Panamericana de la Salud; feb. 18, 2021. 10 p.
No convencional en Español | LILACS | ID: biblio-1151148

RESUMEN

El Centro Panamericano de Fiebre Aftosa y Salud Pública Veterinaria de la Organización Panamericana de la Salud / Organización Mundial de la Salud (PANAFTOSA-OPS/OMS) y la Protección Animal Mundial (PAM) comunican al público en general los aspectos referentes al COVID-19 y la relación con las mascotas (perros y gatos).


Asunto(s)
Animales , Gatos , Perros , Neumonía Viral/transmisión , Infecciones por Coronavirus/transmisión , Pandemias/prevención & control , Monitoreo Epidemiológico/veterinaria , Betacoronavirus/patogenicidad
3.
Brasília; CONASS; 2021. 326 p.
Monografía en Portugués | LILACS, Coleciona SUS, CONASS | ID: biblio-1150771

RESUMEN

A partir dos desafios para a efetivação do direito à saúde, o Volume 6 ­ Reflexões e Futuro ­ apresenta debates relacionados às questões ambientais, urbanas, das relações humano-natureza, das arboviroses ­ que juntos contribuem para a análise da conformação do futuro pós-pandemia. Nessa esteira seguem análises relacionadas à saúde pública, à sociedade brasileira, à infoestrutura como apoio às decisões estratégicas e a avaliação, como dispositivo potente para a gestão. Ainda em sede de desafios, o livro aborda a Vigilância Sanitária como elemento primordial para o enfrentamento das emergências em saúde pública e nesse escopo se insere o Programa Nacional de Imunizações (PNI), do Brasil. À títulos comparativos, há narrativas acerca do enfrentamento da pandemia nos países de língua portuguesa, especialmente Portugal, bem como no Canadá e no Quebec possibilitando aprendizados com as experiências de outros sistemas universais. A abordagem acerca das políticas governamentais de compras públicas, da imagem do SUS nos contextos, nas narrativas e para as pessoas são encerradas com reflexões sobre a cobertura sanitária enquanto valor e a reforma sanitária brasileira como necessidade atual. Ainda que esse levante editorial se encerre, por ora, no volume 6 da Coleção COVID-19, a pandemia continua e outros tantos elementos poderão ser percebidos, contextualizados e merecerão registro. O Conass envida agradecimentos aos que estiveram empenhados em registrar seus diferentes campos de observação: gestores, auditores, ministros, médicos, pesquisadores, farmacêuticos, cientistas sociais, juízes, antropólogos, promotores, advogados, cientistas de dados, administradores, professores, comunicadores e todos que contribuíram com a análise e possíveis aperfeiçoamentos da gestão estadual do SUS no enfrentamento das emergências sanitárias.


Asunto(s)
Humanos , Neumonía Viral/epidemiología , Infecciones por Coronavirus/epidemiología , Pandemias/prevención & control , Monitoreo Epidemiológico , Betacoronavirus/patogenicidad , Infecciones por Arbovirus , Sistema Único de Salud/organización & administración , Brasil/epidemiología , Programas de Inmunización/organización & administración , Políticas Públicas de Salud
4.
Brasília; CONASS; 2021. 314 p.
Monografía en Portugués | LILACS, Coleciona SUS, CONASS | ID: biblio-1150765

RESUMEN

No Brasil, as competências e regras a que se submetem os entes federados e as diferentes instituições afetas ao direito à saúde, conformaram-se no conteúdo desse livro. As Comissões Intergestores do SUS, o Congresso Nacional e o Tribunal de Contas da União (TCU), os conselhos nacionais de Justiça (CNJ) e do Ministério Público (CNMP), agências reguladoras (Anvisa) e o Conselho Nacional de Saúde (CNS) exararam manifestações por estratégias e instrumentação diversa, descritas e analisadas. As estratégias de saúde digital e da comunicação em saúde estiveram sob avaliação, assim como o desempenho do Conass e das Secretarias Estaduais de Saúde (SES), em especial no quesito transparência das informações. Ainda nessa seara, os textos aqui compilados trouxeram ao debate questões relacionadas às transferências de recursos federais aos cofres estaduais, às requisições administrativas e aos dilemas que circundam o âmbito fiscal do SUS. Numa tentativa de agrupar os principais comandos, estão apresentados o rol de leis e atos administrativos, a normativa regulatória sanitária e a interpretação do poder judiciário acerca da legislação, especialmente sob o crivo da responsabilização dos gestores públicos. Quando iniciada a organização da Coleção COVID-19, a principal expectativa era que a disponibilização de seu conteúdo ocorresse num cenário em que as medidas de prevenção, controle e até mesmo mitigação tivessem apresentado as melhores respostas, no Brasil e no mundo. Mas, o recrudescimento do número de infectados e dos óbitos já é um fato. Novas medidas, não farmacológicas, dessa vez acompanhadas das campanhas de vacinação em vários países, já são realidade no âmbito dos territórios. Portanto, o tempo permitirá perceber outros tantos comandos normativos afetos à saúde pública no Brasil e no mundo, o que requererá atenção do leitor quanto à necessidade de pesquisa e atualização. Conforme já asseverado, os textos revelam as opiniões de seus autores, ainda que porventura divirjam das posições do Conass. Que os diferentes posicionamentos compilados no Volume 3 ­ Competências e Regras ­ sejam capazes de denotar limites e potencialidades para a gestão, bem como possam contribuir com aprendizados para o futuro!


Asunto(s)
Humanos , Neumonía Viral/epidemiología , Infecciones por Coronavirus/epidemiología , Pandemias/prevención & control , Monitoreo Epidemiológico , Betacoronavirus/patogenicidad , Sistema Único de Salud/organización & administración , Grupos de Riesgo , Brasil/epidemiología , Colaboración Intersectorial , Telemedicina/organización & administración , Gestión en Salud
5.
Rev. patol. respir ; 23(supl.3): 246-250, dic. 2020. ilus, graf
Artículo en Español | IBECS | ID: ibc-197099

RESUMEN

Desde 2002, tras la epidemia de síndrome respiratorio agudo grave (SARS), expertos virólogos y epidemiólogos han alertado durante años de la posibilidad de una pandemia. En diciembre de 2019 se produjo un brote epidémico por un nuevo coronavirus, el SARS-CoV-2, que, a fecha de 2 de noviembre de 2020, ha causado 46.597.299 casos de infección en el mundo y 1.201.162 muertes. España es el segundo país con mayor incidencia de la Unión Europea, con 530,7 casos por 100.000 habitantes, con una tasa de letalidad del 4,5%. El SARS-CoV-2 es un virus de cadena simple de ácido ribonucleico de sentido positivo compactada en forma helicoidal por la proteína N, con una envoltura proteica donde destaca la proteína S, responsable de la entrada del virus en el citoplasma celular a través de la enzima conversora de la angiotensina 2. La actual revisión pretende realizar un resumen de los datos claves de la enfermedad que conocemos hasta este momento


Since 2002, after the Severe acute respiratory syndrome (SARS) epidemic, virologists and epidemiologists have warned for years of the possibility of a pandemic. In December 2019, there was an epidemic outbreak caused by a new coronavirus, SARS-CoV-2, which has caused 46,597,299 cases worldwide and 1,202,162 deaths. Spain is the second country with the highest incidence in the European Union with 530,7 cases per 100,000 inhabitants, with a fatality rate of 4,5%. SARS-CoV-2 is a positive-sense ribonucleic acid single chain virus helically compacted by protein N. Protein S is part of the envelope and responsible for the entry of the virus into the cell cytoplasm through the angiotensin converting enzyme 2. The current review is intended to summarize the key data of the disease that we know so far


Asunto(s)
Humanos , Infecciones por Coronavirus/epidemiología , Infecciones por Coronavirus/fisiopatología , Neumonía Viral/epidemiología , Neumonía Viral/fisiopatología , Pandemias , Infecciones por Coronavirus/transmisión , Neumonía Viral/transmisión , Betacoronavirus/patogenicidad
6.
Angiol. (Barcelona) ; 72(6): 286-297, nov.-dic. 2020. tab
Artículo en Español | IBECS | ID: ibc-195584

RESUMEN

El SARS-CoV-2, responsable de la pandemia, ha demostrado un alto potencial trombogénico y, a pesar de ser un virus de reciente aparición, evidencia una relación estrecha con mecanismos fisiopatológicos previamente descritos. La enfermedad tromboembólica venosa es una de sus complicaciones más frecuentes, cuya presencia es directamente proporcional al incremento en la mortalidad de estos pacientes. En el contexto del SARS-CoV-2, si bien las heparinas han mostrado superioridad frente a otros fármacos por su efecto antiinflamatorio añadido, no se logra un consenso sobre su dosificación en los diferentes escenarios y, en condiciones de alta hospitalaria, la elección de la droga más idónea y la duración de la profilaxis farmacológica también han generado controversias y discrepancias. Tras una revisión exhaustiva y basada en la literatura publicada tanto en la era COVID-19 como en años pasados, presentamos para su discusión la escala de coagulopatía inducida por sepsis (SIC) y el valor del dímero D como parámetros objetivos frente a las incertidumbres planteadas. Además, se sugiere el uso de escalas previamente validadas y manejadas para evaluar el riesgo tromboembólico venoso, el sangrado y las probabilidades de sospecha diagnóstica de trombosis venosa profunda y embolia pulmonar, las mismas que podrían ayudar a reducir sesgos subjetivos


SARS-CoV-2, responsible for the pandemic; has shown a high thrombogenic potential, but; despite being a newly emerging virus, it shows a close relationship with previously described pathophysiological mechanisms. Venous thromboembolic disease is the most frequent complication and it is directly proportional to the increase in mortality in these patients. In SARS-CoV-2 context, heparins have shown superiority over other drugs for their anti-inflammatory effect but there is not an established consensus about their dosage in different stages of the disease; moreover, at hospital discharge, the most suitable drug choice and pharmacological prophylaxis duration is controversial. After an exhaustive review and based in both, current COVID-19 era literature and the past years related scientific information, we propose sepsis-induced coagulopathy (SIC) score and D-dimer quantification as objective parameters; in addition, we suggest the use of previously validated scores to assess venous thromboembolic risk, bleeding and diagnostic suspicion of deep vein thrombosis and pulmonary embolism; these could help to reduce subjective bias and try to clear uncertainties about this topic


Asunto(s)
Humanos , Infecciones por Coronavirus/complicaciones , Betacoronavirus/patogenicidad , Tromboembolia Venosa/virología , Factores de Riesgo , Medición de Riesgo , Tromboembolia Venosa/prevención & control , Anticoagulantes/uso terapéutico , Profilaxis Pre-Exposición/métodos , Infecciones por Coronavirus/prevención & control
7.
Int. j. odontostomatol. (Print) ; 14(4): 519-522, dic. 2020.
Artículo en Español | LILACS | ID: biblio-1134530

RESUMEN

RESUMEN: La pandemia por COVID-19 ha hecho que la atención odontológica de rutina se suspenda. La causa principal es el pobre control del aerosol en la consulta dental. Los aerosoles liberados por el instrumental odontológico son esenciales para la remoción de los tejidos bucales enfermos. Sin embargo, al mezclarse con saliva o sangre contaminada, los aerosoles pueden diseminar microorganismos infectivos fuera de la boca del paciente. Existe evidencia de que el SARS-CoV-2 se encuentra en la saliva del 91,7 % de los sujetos enfermos. Este artículo presenta evidencias y reflexiones para el control del aerosol odontológico, las que podrían permitir aumentar la seguridad del ejercicio de la odontología durante la pandemia y pospandemia.


ABSTRACT: The COVID-19 pandemic has caused routine dental check-ups to be cancelled. The main cause is poor aerosol control in the dental office. Aerosols released by dental instruments are essential for the removal of diseased oral tissues. However, when mixed with saliva or contaminated blood, aerosols can spread infectious microorganisms out of the patient's mouth. In addition, SARS-CoV-2 has been detected in the self-collected saliva of 91.7 % of patients. This article presents evidence and reflections for the control of dental aerosol, which could allow increasing the safety of dental practice during the pandemic and post-pandemic.


Asunto(s)
Humanos , Infecciones por Coronavirus/epidemiología , Odontología/normas , Betacoronavirus/patogenicidad , Infecciones por Coronavirus/prevención & control , Aerosoles
8.
Eur Rev Med Pharmacol Sci ; 24(21): 11395-11401, 2020 11.
Artículo en Inglés | MEDLINE | ID: mdl-33215461

RESUMEN

OBJECTIVE: Many studies have reported arrhythmia to be associated with coronavirus disease (COVID-19), but no meta-analysis has explored whether arrhythmia is related to COVID-19 severity. Therefore, the purpose of this study was to evaluate arrhythmia in patients with severe and non-severe COVID-19 during the current COVID-19 pandemic. MATERIALS AND METHODS: We searched PubMed, Embase, Web of Science, and the Cochrane Library for case control studies that were published between January 1 and July 25, 2020, and that had data on arrhythmia in patients with COVID-19. Random effects model was used with the odds ratio as the effect size. The frequency of arrhythmia was compared between COVID-19 patients with and without the composite endpoint of severity. We also determined the pooled prevalence of arrhythmia in patients with COVID-19. Publication bias and heterogeneity were considered by using subgroup analyses, meta-regression, and the trim and fill method. RESULTS: A total of 1553 patients with COVID-19 were included in the 5 articles we obtained. Of these, 349 cases (22.47%) and 1204 cases (77.53%) were severely ill and non-severely ill inpatients with COVID-19 pneumonia, respectively. There were 790 (50.87%) male patients. A total of 105 cases (30.09%) of severely ill inpatients with COVID-19 pneumonia had arrhythmia complications, and 34 cases (2.82%) of non-severely ill inpatients with COVID-19 pneumonia had arrhythmia complications. We found arrhythmia to be significantly associated with severely ill inpatients with COVID-19 pneumonia, with a pooled odds ratio of 17.97 (95% CI (11.30, 28.55), p<0.00001). CONCLUSIONS: This study showed that the incidence of arrhythmia in patients with severe COVID-19 was greater than that of those with non-severe COVID-19. Patients with severe COVID-19 had a higher risk of arrhythmia complications, which further showed that COVID-19 may be a risk factor for arrhythmia and that the incidence of arrhythmia may increase with the progression of the disease. More importantly, this meta-analysis graded the reliability of evidence for further basic and clinical research into arrhythmia in patients with COVID-19.


Asunto(s)
Arritmias Cardíacas/epidemiología , Betacoronavirus/patogenicidad , Infecciones por Coronavirus/complicaciones , Neumonía Viral/complicaciones , Arritmias Cardíacas/etiología , Arritmias Cardíacas/terapia , Betacoronavirus/aislamiento & purificación , Infecciones por Coronavirus/diagnóstico , Infecciones por Coronavirus/inmunología , Infecciones por Coronavirus/terapia , Humanos , Incidencia , Pandemias , Neumonía Viral/diagnóstico , Neumonía Viral/inmunología , Neumonía Viral/terapia , Factores de Riesgo , Índice de Severidad de la Enfermedad
9.
Eur Rev Med Pharmacol Sci ; 24(21): 11402-11408, 2020 11.
Artículo en Inglés | MEDLINE | ID: mdl-33215462

RESUMEN

OBJECTIVE: The study aimed to explore the best follow-up management strategy for patients undergoing peritoneal dialysis (PD) during the novel coronavirus pneumonia (NCP) epidemic. PATIENTS AND METHODS: Patients undergoing PD who were followed up during the NCP epidemic by our hospital were enrolled in this study. Because of the need to control the epidemic, a follow-up system was established during the epidemic period, with WeChat, QQ, and the telephone as the main methods of communication. Outpatient and emergency follow-ups were carried out to ensure the safety of dialysis and the prevention and control of the epidemic. The follow-up strategy included response measures related to the epidemic situation, prevention of peritonitis related to PD, water and salt control, exercise guidance, and psychological care. According to the patient's condition, the appointment system was implemented, with one consulting room and one process for each patient. The emergency patients were isolated in accordance with the epidemic situation. RESULTS: Since January 2020, among the 580 patients undergoing PD who were followed up in our department and their families, none had NCP infection. During the epidemic period, the standard hemoglobin level and the inpatient rate decreased. Complications related to PD, such as peritonitis, cardiovascular complications caused by volume overload, and pulmonary infection, did not significantly increase, and the withdrawal rate and mortality rate decreased compared with those in the same period last year. CONCLUSIONS: The patient follow-up strategy during the epidemic period had a significant positive effect on preventing and controlling the epidemic. Furthermore, during the epidemic period, encouraging patients and caregivers to pay attention to protection at home, avoid going out, strengthen self-management, and other measures were beneficial to the control of kidney disease itself, which is worth promoting. The close relationship between doctors and patients during the epidemic had a positive effect on the occurrence of complications related to patients undergoing PD.


Asunto(s)
Cuidados Posteriores/métodos , Infecciones por Coronavirus/prevención & control , Hemodiálisis en el Domicilio/normas , Fallo Renal Crónico/terapia , Pandemias/prevención & control , Diálisis Peritoneal/normas , Neumonía Viral/prevención & control , Cuidados Posteriores/normas , Betacoronavirus/patogenicidad , Cuidadores/psicología , Control de Enfermedades Transmisibles/normas , Infecciones por Coronavirus/epidemiología , Infecciones por Coronavirus/transmisión , Infecciones por Coronavirus/virología , Estudios de Seguimiento , Hemodiálisis en el Domicilio/efectos adversos , Hemodiálisis en el Domicilio/psicología , Humanos , Educación del Paciente como Asunto , Diálisis Peritoneal/efectos adversos , Diálisis Peritoneal/psicología , Peritonitis/epidemiología , Peritonitis/etiología , Relaciones Médico-Paciente , Neumonía Viral/epidemiología , Neumonía Viral/transmisión , Neumonía Viral/virología , Guías de Práctica Clínica como Asunto , Derivación y Consulta/normas , Automanejo/psicología , Telemedicina/normas , Resultado del Tratamiento
10.
Eur Rev Med Pharmacol Sci ; 24(21): 11409-11420, 2020 11.
Artículo en Inglés | MEDLINE | ID: mdl-33215463

RESUMEN

OBJECTIVE: Diabetes is a lifestyle disease and it has become an epidemic worldwide in recent decades. In the ongoing COVID-19 pandemic situation, diabetes has become a serious health concern since large numbers of patients are vulnerable to die from the virus. Thus, diabetic patients affected by COVID-19 cause a major health crisis now. Reports show that large occurrence of diabetes makes it a serious comorbidity in COVID-19 patients. MATERIALS AND METHODS: It is crucial to understand how COVID-19 affects diabetes patients. This paper has reviewed published literature extensively to understand the pattern, importance, care, and medication. RESULTS: This review summarizes the association between COVID-19 and diabetes in terms of susceptibility for pneumonia and other diseases. It also discusses the harshness of COVID-19 with diabetes populations and immunological impacts. It further adds the ACE2 receptor role in diabetes with COVID-19 patients. CONCLUSIONS: Finally, this paper illustrates different types of diabetes management techniques, such as blood glucose management, self-management, mental health management, and therapeutic management. It also summarizes the current knowledge about diabetic patients with COVID-19 to fight this pandemic.


Asunto(s)
Betacoronavirus/inmunología , Infecciones por Coronavirus/inmunología , Diabetes Mellitus Tipo 1/complicaciones , Diabetes Mellitus Tipo 2/complicaciones , Susceptibilidad a Enfermedades/inmunología , Neumonía Viral/inmunología , Betacoronavirus/metabolismo , Betacoronavirus/patogenicidad , Glucemia/efectos de los fármacos , Glucemia/metabolismo , Comorbilidad , Infecciones por Coronavirus/diagnóstico , Infecciones por Coronavirus/epidemiología , Infecciones por Coronavirus/prevención & control , Diabetes Mellitus Tipo 1/tratamiento farmacológico , Diabetes Mellitus Tipo 1/epidemiología , Diabetes Mellitus Tipo 1/inmunología , Diabetes Mellitus Tipo 2/tratamiento farmacológico , Diabetes Mellitus Tipo 2/epidemiología , Diabetes Mellitus Tipo 2/inmunología , Humanos , Hipoglucemiantes/administración & dosificación , Páncreas/patología , Pandemias/prevención & control , Peptidil-Dipeptidasa A/metabolismo , Neumonía Viral/diagnóstico , Neumonía Viral/epidemiología , Neumonía Viral/prevención & control , Índice de Severidad de la Enfermedad , Glicoproteína de la Espiga del Coronavirus/metabolismo , Replicación Viral/inmunología
11.
Eur Rev Med Pharmacol Sci ; 24(21): 11381-11385, 2020 Nov.
Artículo en Inglés | MEDLINE | ID: mdl-33215459

RESUMEN

OBJECTIVE: This study aims to discuss the effects of simulation training on improving the pre-examination, triage, prevention, and control of coronavirus disease 2019 (COVID-19), explain the psychological states of pre-examination and triage staff in general hospitals during the COVID-19 epidemic, and analyze relevant influencing factors. This study may serve as a reference of psychological consultation services to medical staff. SUBJECTS AND METHODS: This study included 60 nurses assigned in the pre-examination department, fever clinics, and isolation wards of a general hospital from January 26th to February 1st, 2020. Before assuming the posts, the nurses received simulation training on the clinical reception of suspected patients with COVID-19. Operation skills of the nurses before and after the training were assessed. RESULTS: The percent of passing significantly increased from 65% before the training to 98.33% after training (p<0.05). Training also significantly relieved the anxiety and depression of the nurses (p<0.05). CONCLUSIONS: Scenario-simulation training can increase the emergency abilities of pediatric nurses in the prevention and control of the COVID-19 epidemic and relieve the anxiety of nurses.


Asunto(s)
Infecciones por Coronavirus/prevención & control , Control de Infecciones/organización & administración , Enfermeras Pediátricas/psicología , Estrés Laboral/prevención & control , Pandemias/prevención & control , Neumonía Viral/prevención & control , Entrenamiento Simulado/organización & administración , Adulto , Ansiedad/prevención & control , Ansiedad/psicología , Betacoronavirus/patogenicidad , Competencia Clínica , Infecciones por Coronavirus/diagnóstico , Infecciones por Coronavirus/epidemiología , Infecciones por Coronavirus/psicología , Depresión/prevención & control , Depresión/psicología , Servicio de Urgencia en Hospital/organización & administración , Femenino , Hospitales Pediátricos/organización & administración , Humanos , Control de Infecciones/instrumentación , Transmisión de Enfermedad Infecciosa de Paciente a Profesional/prevención & control , Enfermeras Pediátricas/organización & administración , Exposición Profesional/efectos adversos , Estrés Laboral/psicología , Equipo de Protección Personal , Neumonía Viral/diagnóstico , Neumonía Viral/epidemiología , Neumonía Viral/psicología , Carga de Trabajo/psicología , Adulto Joven
12.
Eur Rev Med Pharmacol Sci ; 24(21): 11386-11394, 2020 Nov.
Artículo en Inglés | MEDLINE | ID: mdl-33215460

RESUMEN

OBJECTIVE: To explore the expression and significance of SAA, CRP and FERR in patients diagnosed with COVID-19. PATIENTS AND METHODS: A total of 225 patients diagnosed with COVID-19 who were admitted to the North Hospital of First Hospital in Changsha, China, from 9th February 2020 to 7th March 2020 were enrolled. Their general data, laboratory test results and levels of SAA, CRP and FERR were extracted from electronic medical records. RESULTS: Age was an important risk factor for the severity of COVID-19 in the patients. Compared with the non-severe group, the severe group showed statistical significance in the levels of total protein, albumin, ALT and AST in liver function, UA in renal function, myocardial enzyme CK-MB and LDH, and immunoglobulin IgG and IgM. The levels of SAA, CRP, and FERR were significantly increased in patients with severe COVID-19. ROC curve analysis results showed that the AUC, from small to large, was as follows: SAA+CRP+FERR, CRP + FERR, SAA + CRP, SAA + FERR, SAA, FERR, and CRP, which indicated the benefit of the combination of the three indicators. The sensitivity and specificity of the combined detection of the three indicators were higher than those of the detection of any single indicator or two combined indicators. A Spearman correlation analysis of the data showed that the initial CRP/SAA, SAA/FERR, and CRP/FERR were positively correlated. The continuous results of SAA, CRP and FERR throughout the study period showed that the values of the severe group on a given day were higher than those of the non-severe group; the values of the two groups peaked on the 5th or 7th day and then decreased, and the decreasing trend of the severe group was more evident. CONCLUSIONS: SAA, CRP and FERR are sensitive serological indicators used to evaluate the severity of COVID-19. The combined detection of serum SAA, FERR, and CRP, which are positively related to COVID-19 infection, offers guiding significance for the occurrence of COVID-19 infection and the severity of the disease. Such detection provides effective detection indicators for the progress and prognosis of COVID-19; these indicators will enable effective intervention measures to be implemented in time and the rates of severe illness and mortality to be reduced.


Asunto(s)
Proteína C-Reactiva/análisis , Infecciones por Coronavirus/diagnóstico , Ferritinas/sangre , Neumonía Viral/diagnóstico , Proteína Amiloide A Sérica/análisis , Adulto , Factores de Edad , Anciano , Betacoronavirus/aislamiento & purificación , Betacoronavirus/patogenicidad , Biomarcadores/sangre , China/epidemiología , Infecciones por Coronavirus/sangre , Infecciones por Coronavirus/mortalidad , Infecciones por Coronavirus/virología , Progresión de la Enfermedad , Femenino , Humanos , Masculino , Persona de Mediana Edad , Pandemias , Neumonía Viral/sangre , Neumonía Viral/mortalidad , Neumonía Viral/virología , Pronóstico , Estudios Retrospectivos , Sensibilidad y Especificidad , Índice de Severidad de la Enfermedad
13.
Eur Rev Med Pharmacol Sci ; 24(21): 11421-11427, 2020 Nov.
Artículo en Inglés | MEDLINE | ID: mdl-33215464

RESUMEN

OBJECTIVE: This study aimed to investigate whether pre-existing chronic obstructive pulmonary disease (COPD) was an independent predictor for adverse outcomes in coronavirus disease 2019 (COVID-19) patients. MATERIALS AND METHODS: We searched electronic databases, including PubMed, Web of Science, EMBASE, and Chinese National Knowledge Infrastructure (CNKI) to screen for eligible articles. A quantitative meta-analysis was performed on the basis of adjusted effect estimates. RESULTS: We observed that COPD was significantly associated with an increased risk of adverse outcomes in COVID-19 patients, which is based on 18 studies with 26,075 cases reporting adjusted effect estimates (pooled effect = 1.53, 95% confidence interval (CI): 1.29-1.8; I2 = 35.4%, random-effects model). CONCLUSIONS: We found that pre-existing COPD was an independent risk factor for predicting the adverse outcomes in COVID-19 patients.


Asunto(s)
Betacoronavirus/patogenicidad , Infecciones por Coronavirus/mortalidad , Pulmón/fisiopatología , Neumonía Viral/mortalidad , Enfermedad Pulmonar Obstructiva Crónica/epidemiología , Índice de Severidad de la Enfermedad , Betacoronavirus/aislamiento & purificación , Infecciones por Coronavirus/diagnóstico , Infecciones por Coronavirus/fisiopatología , Infecciones por Coronavirus/virología , Humanos , Pandemias , Neumonía Viral/diagnóstico , Neumonía Viral/fisiopatología , Neumonía Viral/virología , Enfermedad Pulmonar Obstructiva Crónica/complicaciones , Enfermedad Pulmonar Obstructiva Crónica/fisiopatología , Factores de Riesgo
14.
Eur Rev Med Pharmacol Sci ; 24(21): 11428-11431, 2020 Nov.
Artículo en Inglés | MEDLINE | ID: mdl-33215465

RESUMEN

This paper aims to show the relationship between COVID-19 symptoms and patients' status including recovered and deceased cases. The study uses different CoVID-19 patients' information from different countries, the dataset contains 13174 patients with 730 as recovered and 34 cases as deceased. The Chi-square test is adopted with asymptotic significance level to show the strength of each symptom on recovered and deceased cases independently. The study found that the recovered cases are associated with different symptoms based on the patient history, where the deceased cases showed that high fever is not responsible for increasing the number of deceased cases. In addition, the use of symptoms will not give evidence of the patients' status, and therefore gender, age, reason of infection and patients' province are more dominant in determining the status of patients.


Asunto(s)
Betacoronavirus/patogenicidad , Infecciones por Coronavirus/diagnóstico , Infecciones por Coronavirus/mortalidad , Análisis de Datos , Neumonía Viral/diagnóstico , Neumonía Viral/mortalidad , Factores de Edad , Anciano , Anciano de 80 o más Años , Distribución de Chi-Cuadrado , Conjuntos de Datos como Asunto , Femenino , Humanos , Masculino , Pandemias , Pronóstico , Medición de Riesgo/métodos , Factores de Riesgo , Índice de Severidad de la Enfermedad , Factores Sexuales
15.
Eur Rev Med Pharmacol Sci ; 24(21): 11440-11444, 2020 Nov.
Artículo en Inglés | MEDLINE | ID: mdl-33215467

RESUMEN

OBJECTIVE: A computerized system of telephone consultation has been experimented at the Pediatric Emergency Department (ED) of Policlinico Gemelli Hospital in Rome during the outbreak of Coronavirus Disease 2019 (COVID-19). MATERIALS AND METHODS: Twenty monothematic items with a series of questions to evaluate child's clinical conditions have been set up in order to evaluate the different situations according to their severity. All items were highlighted according to conventional scores corresponding to the different answers (yes/no) given by the child's parents. This system has been implemented with large diffusion of computer programs and applications by the availability of a computer station in every ED room. RESULTS: The system allows healthcare workers to establish the medical check-up urgency which may be immediate, within the next 24 hours or scheduled in the pediatric ward. Therefore, it has been implemented a telephone triage consultation with a standardized method. CONCLUSIONS: Telephone consultation during outbreaks, considering the risks of contagion, allows healthcare workers to decrease the concern of families and to reduce indiscriminate access to ED. The remote approach will not solve logistic and setting problems related to COVID-19 outbreak17, but it would be a valid tool to improve medical evaluation without deep change in infrastructure and clinical organization.


Asunto(s)
Infecciones por Coronavirus/prevención & control , Servicio de Urgencia en Hospital/organización & administración , Pandemias/prevención & control , Neumonía Viral/prevención & control , Derivación y Consulta/organización & administración , Teléfono , Triaje/organización & administración , Betacoronavirus/patogenicidad , Niño , Infecciones por Coronavirus/epidemiología , Infecciones por Coronavirus/transmisión , Infecciones por Coronavirus/virología , Implementación de Plan de Salud , Accesibilidad a los Servicios de Salud/organización & administración , Humanos , Italia/epidemiología , Neumonía Viral/epidemiología , Neumonía Viral/transmisión , Neumonía Viral/virología , Evaluación de Programas y Proyectos de Salud , Centros de Atención Terciaria/organización & administración , Factores de Tiempo
16.
Eur Rev Med Pharmacol Sci ; 24(21): 11445-11454, 2020 Nov.
Artículo en Inglés | MEDLINE | ID: mdl-33215472

RESUMEN

In Italy, SARS-CoV-2 outbreak registered a high transmission and disease rates. During the acute phase, oncologists provided to re-organize services and prioritize treatments, in order to limit viral spread and to protect cancer patients. The progressive reduction of the number of infections has prompted Italian government to gradually loosen the national confinement measures and to start the "Second phase" of measures to contain the pandemic. The issue on how to organize cancer care during this post-acute SARS-CoV-2 phase appears crucial and a reassessment of healthcare services is needed requiring new models of care for oncological patients. In order to address major challenges in cancer setting during post-acute SARS-CoV-2 phase, this work offers multidimensional solutions aimed to provide a new way to take care of cancer patients.


Asunto(s)
Control de Enfermedades Transmisibles/organización & administración , Infecciones por Coronavirus/prevención & control , Oncología Médica/organización & administración , Modelos Organizacionales , Neoplasias/terapia , Pandemias/prevención & control , Neumonía Viral/prevención & control , Betacoronavirus/patogenicidad , Técnicas de Laboratorio Clínico/normas , Control de Enfermedades Transmisibles/normas , Infecciones por Coronavirus/diagnóstico , Infecciones por Coronavirus/epidemiología , Infecciones por Coronavirus/transmisión , Servicios de Atención a Domicilio Provisto por Hospital/organización & administración , Servicios de Atención a Domicilio Provisto por Hospital/normas , Humanos , Italia/epidemiología , Oncología Médica/normas , Neoplasias/diagnóstico , Neumonía Viral/diagnóstico , Neumonía Viral/epidemiología , Neumonía Viral/transmisión , Triaje/organización & administración , Triaje/normas
17.
Sensors (Basel) ; 20(22)2020 Nov 18.
Artículo en Inglés | MEDLINE | ID: mdl-33218097

RESUMEN

The coronavirus disease 2019 (COVID-19) pandemic is considered a public health emergency of international concern. The 2019 novel coronavirus (2019-nCoV) or severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that caused this pandemic has spread rapidly to over 200 countries, and has drastically affected public health and the economies of states at unprecedented levels. In this context, efforts around the world are focusing on solving this problem in several directions of research, by: (i) exploring the origin and evolution of the phylogeny of the SARS-CoV-2 viral genome; (ii) developing nanobiosensors that could be highly effective in detecting the new coronavirus; (iii) finding effective treatments for COVID-19; and (iv) working on vaccine development. In this paper, an overview of the progress made in the development of nanobiosensors for the detection of human coronaviruses (SARS-CoV, SARS-CoV-2, and Middle East respiratory syndrome coronavirus (MERS-CoV) is presented, along with specific techniques for modifying the surface of nanobiosensors. The newest detection methods of the influenza virus responsible for acute respiratory syndrome were compared with conventional methods, highlighting the newest trends in diagnostics, applications, and challenges of SARS-CoV-2 (COVID-19 causative virus) nanobiosensors.


Asunto(s)
Betacoronavirus/aislamiento & purificación , Técnicas Biosensibles , Infecciones por Coronavirus/diagnóstico , Nanotecnología , Neumonía Viral/diagnóstico , Betacoronavirus/patogenicidad , Infecciones por Coronavirus/virología , Humanos , Coronavirus del Síndrome Respiratorio de Oriente Medio/genética , Coronavirus del Síndrome Respiratorio de Oriente Medio/aislamiento & purificación , Coronavirus del Síndrome Respiratorio de Oriente Medio/patogenicidad , Pandemias , Neumonía Viral/virología
18.
Sensors (Basel) ; 20(22)2020 Nov 11.
Artículo en Inglés | MEDLINE | ID: mdl-33187119

RESUMEN

Greenhouses and indoor farming systems play an important role in providing fresh and nutritious food for the growing global population. Farms are becoming larger and greenhouse growers need to make complex decisions to maximize production and minimize resource use while meeting market requirements. However, highly skilled labor is increasingly lacking in the greenhouse sector. Moreover, extreme events such as the COVID-19 pandemic, can make farms temporarily less accessible. This highlights the need for more autonomous and remote-control strategies for greenhouse production. This paper describes and analyzes the results of the second "Autonomous Greenhouse Challenge". In this challenge, an experiment was conducted in six high-tech greenhouse compartments during a period of six months of cherry tomato growing. The primary goal of the greenhouse operation was to maximize net profit, by controlling the greenhouse climate and crop with AI techniques. Five international teams with backgrounds in AI and horticulture were challenged in a competition to operate their own compartment remotely. They developed intelligent algorithms and use sensor data to determine climate setpoints and crop management strategy. All AI supported teams outperformed a human-operated greenhouse that served as reference. From the results obtained by the teams and from the analysis of the different climate-crop strategies, it was possible to detect challenges and opportunities for the future implementation of remote-control systems in greenhouse production.


Asunto(s)
Inteligencia Artificial , Infecciones por Coronavirus/epidemiología , Lycopersicon esculentum/crecimiento & desarrollo , Pandemias , Neumonía Viral/epidemiología , Agricultura/tendencias , Betacoronavirus/patogenicidad , Clima , Humanos
19.
Pan Afr Med J ; 35(Suppl 2): 147, 2020.
Artículo en Inglés | MEDLINE | ID: mdl-33193962

RESUMEN

Coronavirus disease (COVID-19) caused by SARS-CoV-2-a new single-stranded RNA virus with respiratory system proclivity and epithelial cell- is a novel infectious disease that originated in Wuhan, China in December, 2019 and has spread to many countries with the total number of confirmed cases put at 20,259,579 cases as of 12th August, 2020. It is transmitted from human-to-human via droplets. When an infected person coughs or sneezes, these droplets find their way into the mouth or nostrils of another person that is within a close range. Alternatively it can be contracted by touching infected hard surfaces and using the same hands to touch the mouth, nose and eye(s). COVID-19 has been declared a global pandemic by the World Health Organization (WHO) on 11th March, 2020. There is currently no therapeutic substance accepted as a panacea for the prophylaxis of this infectious disease. As a result of this back drop, many nations have instituted fourteen (14) days quarantine for suspected cases, social distancing and border closure in an attempt to curb the spread of COVID-19. There has been several conspirary theories that emanated since the disease was declared a pandemic. This paper provides useful information to serve as reference to those who seek proper understanding of COVID-19 and its deleterious effects in the body, by distiguishing between the factsand the conspiracy theoriesof coronavirus disease.


Asunto(s)
Actitud Frente a la Salud , Betacoronavirus/patogenicidad , Infecciones por Coronavirus/epidemiología , Deluciones , Pandemias , Neumonía Viral/epidemiología , Aerosoles , Microbiología del Aire , Betacoronavirus/fisiología , Bioterrorismo , Control de Enfermedades Transmisibles/organización & administración , Infecciones por Coronavirus/tratamiento farmacológico , Infecciones por Coronavirus/prevención & control , Infecciones por Coronavirus/terapia , Infecciones por Coronavirus/transmisión , Decepción , Fómites , Genocidio , Agencias Gubernamentales , Personal de Salud , Humanos , Pandemias/prevención & control , Neumonía Viral/prevención & control , Neumonía Viral/terapia , Neumonía Viral/transmisión , Política , Cuarentena , Investigadores , Medios de Comunicación Sociales
20.
Pan Afr Med J ; 35(Suppl 2): 150, 2020.
Artículo en Inglés | MEDLINE | ID: mdl-33193965

RESUMEN

The new coronavirus 2019 epidemic declared in China on December 31, 2019 soon spread to the rest of the world, becoming the subject of an unprecedented health pandemic according to the World Health Organization's declaration of March 11, 2020. It is a disease that has the potential to cause multiple systemic infections. We report here the case of an acute polyradiculoneuritis of the Guillain-Barré type (GBS) indicative of a COVID-19 infection. This is a 41 year old patient seen for ascending, symmetrical and bilateral, progressive and acute tetraparesis with in a context of influenza syndrome and digestive infections treated 2 weeks earlier. During a COVID-19 infection, certain inflammatory cells stimulated by the virus produce inflammatory cytokines creating immune-mediated processes. The same mechanism is observed in GBS being also an immune-mediated disorder. The management of this disease in COVID-19 positive patients does not differ from that of patients who do not carry the virus. The risk of respiratory distress in COVID-19 positive patients becomes twice as great in patients with GBS who test positive for COVID-19 at the same time. Monitoring for hemodynamic disorders and respiratory distress in a neuro-intensive care unit may be fruitful.


Asunto(s)
Betacoronavirus/patogenicidad , Infecciones por Coronavirus/complicaciones , Síndrome de Guillain-Barré/etiología , Neumonía Viral/complicaciones , Adulto , Fibrilación Atrial/complicaciones , Azitromicina/uso terapéutico , Betacoronavirus/aislamiento & purificación , Cloroquina/efectos adversos , Cloroquina/uso terapéutico , Técnicas de Laboratorio Clínico , Terapia Combinada , Contraindicaciones de los Medicamentos , Infecciones por Coronavirus/diagnóstico , Infecciones por Coronavirus/terapia , Diagnóstico Precoz , Síndrome de Guillain-Barré/diagnóstico , Síndrome de Guillain-Barré/fisiopatología , Síndrome de Guillain-Barré/terapia , Humanos , Masculino , Debilidad Muscular/etiología , Nasofaringe/virología , Trastornos del Olfato/etiología , Terapia por Inhalación de Oxígeno , Pandemias , Neumonía Viral/diagnóstico , Neumonía Viral/terapia , Cuadriplejía/etiología , Respiración Artificial , Incontinencia Urinaria/etiología
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