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1.
Oral Health Prev Dent ; 19(1): 217-227, 2021 Jan 07.
Artículo en Inglés | MEDLINE | ID: mdl-33829719

RESUMEN

PURPOSE: To develop an evidence-based Clinical Practice Guideline (CPG) on caries management for the Malaysian population using the ADAPTE trans-contextual adaptation framework. MATERIALS AND METHODS: A systematic search was conducted to identify all CPGs related to caries management on guideline repository websites and other platforms. The search findings were screened and the quality of the identified guidelines was evaluated using the AGREE II tool. The currency and the content of the recommendations were assessed by multidisciplinary experts for local adaptation. RESULTS: Following an extensive assessment, six high-quality CPGs were selected for adaptation. Subsequent to the content assessment, the multidisciplinary experts agreed to adopt 24 recommendations, adapt 55, and exclude two recommendations. The adaptation process generated 21 recommendations for caries management in Malaysia. The formulation of the final evidence-based recommendations for caries management in Malaysia was based on the feedback given by the external reviewers. CONCLUSION: The use of the trans-contextual adaptation process is feasible for the development of local guidelines when there are scarce resources and insufficient local evidence. The involvement of the multidisciplinary experts ensures the comprehensiveness of the CPG in terms of its quality and validity and subsequently promotes adherence and ownership of the CPG at the local settings.


Asunto(s)
Caries Dental , Prestación de Atención de Salud , Caries Dental/prevención & control , Humanos , Malasia
2.
J Am Dent Assoc ; 152(4): 269-276.e2, 2021 Apr.
Artículo en Inglés | MEDLINE | ID: mdl-33775286

RESUMEN

BACKGROUND: Untreated caries (UC), although highly prevalent, is largely preventable. Information on the contribution of different teeth to UC prevalence and severity could be helpful in evaluating UC surveillance protocols and the relative benefits of caries prevention interventions. METHODS: The authors combined data from 3 cycles (2011-2016) of the National Health and Nutrition Examination Survey for participants aged 6 through 11 years, 12 through 19 years, 20 through 34 years, 35 through 49 years, 50 through 64 years, 65 through 74 years, and 75 years and older. For each age group the authors calculated the contribution of successive permanent tooth types (for example, first molars and second molars) to UC prevalence and severity. RESULTS: UC prevalence and the percentage of prevalence detected by means of screening molars were, respectively, 5% and 95% among participants aged 6 through 11 years; 16% and 92% among participants aged 12 through 19 years; 29% and 86% among participants aged 20 through 34 years; 26% and 70% among participants aged 35 through 49 years; 21% and 48% among participants aged 50 through 64 years; 16% and 36% among participants aged 65 through 74 years; and 17% and 25% among participants 75 years and older. Among adults aged 50 years and older, no teeth appeared to capture a disproportionate share of UC prevalence. Molars accounted for 87%, 79%, and 56% of severity among participants aged 6 through 11 years, 12 through 19 years, and 20 through 34 years, respectively. After age 34 years, molars accounted for less than 50% of severity. CONCLUSIONS: Molars are the tooth type most susceptible to UC well into adulthood. PRACTICAL IMPLICATIONS: Molars could be used as sentinel teeth for surveillance of UC and adults could benefit from caries prevention that targets molars.


Asunto(s)
Caries Dental , Selladores de Fosas y Fisuras , Adulto , Anciano , Niño , Caries Dental/epidemiología , Caries Dental/prevención & control , Susceptibilidad a Caries Dentarias , Dentición Permanente , Humanos , Persona de Mediana Edad , Encuestas Nutricionales , Vigilancia en Salud Pública , Adulto Joven
3.
Hua Xi Kou Qiang Yi Xue Za Zhi ; 39(1): 53-57, 2021 Feb 01.
Artículo en Inglés, Chino | MEDLINE | ID: mdl-33723937

RESUMEN

OBJECTIVES: To investigate caries status and its impact factors in preschool children in plateau and to provide reference for caries prevention in highlands. METHODS: Examination of caries was performed on 1 597 children aged 3-5 years old in 11 kindergartens in Changdu, Xizang, in accordance with the 4th National Oral Health Survey standards and methods. Their parents were surveyed with the questionnaire regarding oral hygiene habit and consciousness about oral health and related factors. All the data were collected and analyzed. RESULTS: The prevalence of caries among children aged 3-5 years old in Changdu was 52.85%, with dmft index of 2.44. The caries rate and dmft of children aged 3 years old were lower than those of children aged 4 and 5 years old (P<0.05). No significant difference was observed in the caries rate between males and females (P>0.05). Single-factor analysis showed that the frequency of brushing teeth more than twice a day, low frequency of eating sweets, high frequency of drinking butter tea, and regular oral examination can reduce the rate of caries (P<0.05). Multivariate logistic analysis showed that the frequency of eating sweets, drinking butter tea, and oral examination are related impact factors of caries. CONCLUSIONS: The prevalence of ca-ries in children aged 3-5 years old in Changdu increases with aging. Good oral hygiene and eating habits and regular oral examination can reduce the rate of caries.


Asunto(s)
Caries Dental , Preescolar , Estudios Transversales , Índice CPO , Caries Dental/epidemiología , Caries Dental/prevención & control , Susceptibilidad a Caries Dentarias , Femenino , Humanos , Masculino , Salud Bucal , Higiene Bucal , Prevalencia
4.
Georgian Med News ; (310): 39-44, 2021 Jan.
Artículo en Inglés | MEDLINE | ID: mdl-33658407

RESUMEN

The emergence of new concepts and mechanisms for remineralization is of great interest to study. The study objective was to evaluate the clinical efficiency of use of modern remineralizing formulas: "Enamel-sealing liquid" ("Tiefenfluorid", Humanchemie, Germany), "FluoroLux" (TechnoDent, Russia), "InnoDent" (PLC, "InnoDent", Kazakhstan) and ClinproTM XT Varnish (3M ESPE, Germany) in treatment of focal demineralization. According to the number of studied drugs in the framework of a clinical study, four groups of patients with a diagnosis of caries of enamel were formed (n=36): Group 1 (n=9 people, 30 teeth); Group 2 (n=9 people, 29 teeth); Group 3 (n=9 people, 28 teeth); Group 4 (n=9 people, 31 teeth). Evaluation of the clinical efficacy of enamel caries treatment was carried out using 1) vital staining with a 2% aqueous solution of methylene blue followed by evaluation using a control gradation 10-point grayscale; 2) laser-fluorescence method using the apparatus "DiagnoDent Pen" (KaVo). Statistical processing of the obtained results was performed using the Wilcoxon and Money-Whitney test. The confidence level was considered at p≤0.05. According to the data of laser fluorescence of enamel and vital staining, the median index with high statistical significance decreased in all groups after 3 months compared with the data before treatment. Thus, all the studied drugs showed remineralizing activity in the elimination of enamel demineralization foci. This study is the basis for the search and development of new remineralizing compounds for the prevention and treatment of focal enamel demineralization.


Asunto(s)
Caries Dental , Preparaciones Farmacéuticas , Caries Dental/tratamiento farmacológico , Caries Dental/prevención & control , Susceptibilidad a Caries Dentarias , Alemania , Humanos , Kazajstán , Federación de Rusia , Resultado del Tratamiento
5.
Pediatr Dent ; 43(1): 17-23, 2021 Jan 15.
Artículo en Inglés | MEDLINE | ID: mdl-33662244

RESUMEN

Purpose: Casein phosphopeptide amorphous calcium phosphate fluoride varnish (commercially available as MI Varnish®) is a promising minimally invasive remineralizing agent. The purpose of this study was to compare the effectiveness of intensive application of MI and sodium fluoride (commercially available as Duraphat Varnish®) varnishes on white spot lesion remineralization. Methods: This randomized controlled clinical trial included a sample of 44 healthy three- to five-year-old children with at least four active white spot lesions on their anterior primary teeth. They were allocated into two groups: either a test group (MI Varnish®) or a control group (Duraphat Varnish®). Each group received three consecutive varnish applications two weeks apart. Selected teeth were evaluated for lesion activity and change in DIAGNOdent™ readings at follow-up periods of six, 18, and 30 weeks. Results: Both groups showed a significant decrease in the mean oral hygiene debris index score at different follow-up periods compared to baseline (P<0.001). MI Varnish® intervention had a significantly decreased number of active lesions when compared to Duraphat Varnish®, at the 18 week time period. DIAGNOdent ™ scores were significantly reduced in the test group versus the control group at the 30 week assessment (P<0.001). Conclusion: MI Varnish® was more effective than Duraphat Varnish® in white spot lesions mineralization.


Asunto(s)
Caseínas , Caries Dental , Fosfatos de Calcio , Cariostáticos/uso terapéutico , Niño , Preescolar , Caries Dental/tratamiento farmacológico , Caries Dental/prevención & control , Fluoruros , Fluoruros Tópicos , Humanos , Fosfopéptidos , Fluoruro de Sodio , Remineralización Dental , Diente Primario
6.
Evid Based Dent ; 22(1): 18-19, 2021 01.
Artículo en Inglés | MEDLINE | ID: mdl-33772124

RESUMEN

Design Three-armed randomised clinical trial.Study selection The study's aim was to examine the effectiveness of providing oral health promotion, prevention and a restorative programme at mother and child health clinics (MCHs) through a multidisciplinary team. This was studied by collecting data on the participants' caries rates. The study sample consisted of 368 Peruvian children, aged 0-3 years, who were from low socioeconomic areas of Peru and were studied over three different MCHs. The interventions used in this study are split into active intervention group (AG), passive intervention group (PG) and control group (CG). The AG group had multiple interventions, such as multiple training courses for nurses on dental health, oral health-related information cards (OHICs) and atraumatic restorative treatment (ART)-trained dentists. The PG implemented OHICs and ART-trained dentists, and the CG nurses received a 45-minute lecture on the importance of oral health and regular protocols followed.Data analysis/data extraction and synthesis Caries Assessment Spectrum and Treatment (CAST) scores were used to measure the participants' caries rates. The CAST scores were collected over a three-year period by two calibrated and trained dentists. The CAST scores ranged from 0 (no caries) to 8 (loss of tooth due to caries), although the authors only collected data from scores 3-8 as this was indicating disease presence.Results The results were gathered for each arm of the study and compared using analysis of variance. The results showed that it was statistically significant (P <0.001) that the AG group had a lower rate of carious dentine compared to the PG and CG groups. The percentage of carious dentine prevalence was 10%, 60.5% and 63.0%, respectively.Conclusion The conclusion of the paper is that using a multidisciplinary approach - with trained nurses, delivery of oral health inspection and advice - can reduce the rate of caries in 0-3-year-olds.


Asunto(s)
Tratamiento Restaurativo Atraumático Dental , Caries Dental , Niño , Preescolar , Caries Dental/epidemiología , Caries Dental/prevención & control , Países en Desarrollo , Promoción de la Salud , Humanos , Lactante , Recién Nacido , Perú
7.
Artículo en Inglés | MEDLINE | ID: mdl-33535581

RESUMEN

(1) Background: The objective is to systematically review the evidence on intervention programs aiming at reducing inequality in dental caries among children. (2) Methods: Two independent investigators searched MEDLINE, Cochrane library, and Ovid up to December 2020 to identify intervention studies assessing the impact on socioeconomic inequalities in dental caries among children. The interventions included any health promotion/preventive intervention aiming at reducing caries among children across different socioeconomic groups. Comparison groups included children with alternative or no intervention. Cochrane criteria were used to assess interventional studies for risk of bias. (3) Results: After removal of duplicate studies, 1235 articles were retained. Out of 43 relevant papers, 13 articles were identified and used in qualitative synthesis, and reported quantifiable outcomes. The included studies varied in measurements of interventions, sample size, age groups, and follow-up time. Five studies assessed oral health promotion or health-education, four assessed topical fluorides, and four assessed water fluoridation. Interventions targeting the whole population showed a consistent reduction of socioeconomic inequalities in dental caries among children. (4) Conclusion: The quality of included papers was moderate. High heterogeneity did not allow aggregation of the findings. The overall findings suggest that whole population interventions such as water fluoridation are more likely to reduce inequalities in children's caries than target population and individual interventions.


Asunto(s)
Caries Dental , Niño , Caries Dental/epidemiología , Caries Dental/prevención & control , Fluoruración , Fluoruros Tópicos , Promoción de la Salud , Humanos , Salud Bucal
8.
J Am Dent Assoc ; 152(3): 224-233.e11, 2021 03.
Artículo en Inglés | MEDLINE | ID: mdl-33632412

RESUMEN

BACKGROUND: Globally, children's caries prevalence exceeds 30% and has not markedly changed in 30 years. School-based caries prevention programs can be an effective method to reduce caries prevalence, obviate traditional barriers to care, and use aerosol-free interventions. The objective of this study was to explore the clinical effectiveness of a comprehensive school-based, aerosol-free, caries prevention program. METHODS: The authors conducted a 6-year prospective open cohort study in 33 US public elementary schools, providing care to 6,927 children in communities with and without water fluoridation. After dental examinations, dental hygienists provided twice-yearly prophylaxis, glass ionomer sealants, glass ionomer interim therapeutic restorations, fluoride varnish, toothbrushes, fluoride toothpaste, oral hygiene instruction, and referral to community dentists as needed. The authors used generalized estimating equations to estimate the change in the prevalence of untreated caries over time. RESULTS: The prevalence of untreated caries decreased by more than 50%: from 39% through 18% in phase 1, and from 28% through 10% in phase 2. The per-visit adjusted odds ratio of untreated caries was 0.79 (95% confidence interval, 0.73 to 0.85). CONCLUSIONS AND PRACTICAL IMPLICATIONS: This school-based comprehensive caries prevention program was associated with substantial reductions in children's untreated caries, supporting the concept of expanding traditional practices to include office- and community-based aerosol-free care.


Asunto(s)
Susceptibilidad a Caries Dentarias , Caries Dental , Niño , Estudios de Cohortes , Caries Dental/epidemiología , Caries Dental/prevención & control , Humanos , Prevalencia , Estudios Prospectivos , Instituciones Académicas
9.
Ned Tijdschr Tandheelkd ; 128(2): 87-88, 2021 Feb.
Artículo en Holandés | MEDLINE | ID: mdl-33605257

RESUMEN

A heart transplant procedure is performed on patients who have an end-stage heart disease (severe failure) for whom no other treatment is left. Patients need to take immunosuppressive drugs for the rest of their lives to prevent the rejection of a transplanted heart. A recent overview of scientific literature shows a higher risk of gingival hyperplasia, periodontal conditions, the presence of Candida species and oral malignancies compared to healthy individuals. The association between a heart transplant and dental caries is unclear. A frequent periodical dental check and professional dental cleaning is recommended for heart transplant patients.


Asunto(s)
Caries Dental , Placa Dental , Trasplante de Corazón , Enfermedades Periodontales , Caries Dental/epidemiología , Caries Dental/prevención & control , Trasplante de Corazón/efectos adversos , Humanos , Salud Bucal , Enfermedades Periodontales/epidemiología
10.
J Dent Hyg ; 95(1): 50-56, 2021 Feb.
Artículo en Inglés | MEDLINE | ID: mdl-33627453

RESUMEN

Purpose: The Michigan Caries Prevention Program (MCPP) aimed to reduce the burden of childhood dental disease in the state of Michigan by offering training programs to implement preventive oral health services during well-child medical visits. The purpose of this study was to elicit feedback from the participants of the MCPP and determine which oral health services were implemented post-training, identify implementation barriers and assess provider comfort levels in performing oral screenings and fluoride applications.Methods: A descriptive electronic survey was utilized for data collection. A 15-item survey consisting of multiple choice and Likert scale questions was sent to medical providers who had participated in the MCPP from 2015-2017 (n=1115). Descriptive statistics were used to analyze the data.Results: A total of 170 surveys were completed for a 15% response rate. The majority of the participants were physicians (82%, n=134). Nearly all participants reported performing oral screenings and fluoride varnish application post-training (93%, n=153). Participants felt more comfortable applying fluoride varnish than performing oral screenings (80%, n=121 vs 70%, n=112), respectively. Barriers included lack of time, understaffed, staff resistance, feeling that procedures were outside of their scope of practice and disinterest from parents or safety concerns. A majority (70%, n=112) reported that the MCPP training did not help to establish new relationships with community dental providers.Conclusion: Medical providers indicate that the MCPP training was beneficial and that they were willing and able to incorporate oral health screenings and fluoride varnish applications in their practice, but that they face challenges in developing relationships with dental care providers. Opportunities for dental hygienists to work in non-traditional medical-dental integration practice settings may help to increase oral health services offered to patients and improve communication between health care providers.


Asunto(s)
Caries Dental , Fluoruros , Niño , Caries Dental/diagnóstico , Caries Dental/prevención & control , Susceptibilidad a Caries Dentarias , Humanos , Michigan , Percepción
11.
Prog Orthod ; 22(1): 4, 2021 Jan 25.
Artículo en Inglés | MEDLINE | ID: mdl-33491110

RESUMEN

BACKGROUND: One of the most unfavorable side effects of fixed orthodontic treatment is white spot lesions (WSLs). Although the most important approach is prevention of WSLs, it is also essential to evaluate the efficacy of the remineralization agents. However, there is no concurrence in the literature with respect to the remineralization process of these agents. The objective of the present study was to evaluate the effects of different fluoride varnishes, enamel matrix protein, and self-assembling peptide derivatives with varying chemical compositions on remineralization of artificially created WSLs in vitro using quantitative light-induced fluorescence (QLF). METHODS: Artificial WSLs were created on bovine enamel samples using acidic buffer solution (pH 5, 10 days). Specimens were randomly allocated to six groups (n = 10/group): (1) Emdogain (Straumann, Basel, Switzerland), (2) Curodont Repair (Credentis AG, Switzerland), (3) Duraphat (Colgate-Palmolive, New York, NY), (4) Clinpro XT (3 M ESPE, Pymble, New South Wales, Australia), (5) Enamel Pro Varnish (Premier Dental Products, PA, USA), and (6) control (untreated). The agents were applied to the WSLs according to the manufacturers' instructions. Fluorescence loss (ΔF), lesion area (area), and impact (ΔQ) values of enamel surfaces were quantified by QLF-D BiluminatorTM (Inspektor-Pro, Amsterdam, The Netherlands) at baseline and after 7, 14, and 21 days of application of the respective materials. RESULTS: ΔF value presented a significantly decreasing trend throughout the 21 days for all groups except the Duraphat and Enamel Pro varnishes. The changes between 14th and 21st days of the Clinpro XT varnish application were significantly higher than Emdogain, Curodont, and Enamel Pro. The Curodont group showed higher lesion area changes between the first and second week in comparison to the Emdogain, Clinpro XT, and Enamel Pro groups, whereas Clinpro XT assured the highest reduction from the second to the third week of the observation period. CONCLUSIONS: The fluorescence loss was significantly reduced with enamel matrix protein, self-assembling peptide, and light-curable fluoride varnishes in the analysis for 21 days. Curodont and Clinpro XT were effective in diminishing the fluorescence loss and lesion area compared to the Duraphat, Enamel Pro fluoride varnishes, and Emdogain in different time points.


Asunto(s)
Caries Dental , Fluoruros Tópicos , Animales , Cariostáticos , Bovinos , Caries Dental/tratamiento farmacológico , Caries Dental/prevención & control , Humanos , Péptidos , Fluoruro de Sodio , Suiza , Remineralización Dental
13.
Oral Health Prev Dent ; 19(1): 93-99, 2021.
Artículo en Inglés | MEDLINE | ID: mdl-33511823

RESUMEN

PURPOSE: Preschool children with early childhood caries (ECC) frequently exhibit extreme dental anxiety and fear, posing a considerable challenge to paediatric dentists for their treatment. The aim of this study was to evaluate the influence of silver diamine fluoride (SDF) treatment on the oral health-related quality of life (OHRQoL) of uncooperative preschool children using an Arabic version of the Early Childhood Oral Health Impact Scale (A-ECOHIS). MATERIALS AND METHODS: A pre-validated A-ECOHIS was used to assess the sensitivity and responsiveness. Fiftyone children, uncooperative with conventional dental care, underwent SDF treatment; their mothers answered the A-ECOHIS before and 4 weeks after treatment. Based on the global transition rating (GTR), the mothers rated their child's oral health condition following SDF treatment. RESULTS: SDF effectively arrested caries after 4 weeks in all children. There was a statistically significant reduction in mean scores of the total A-ECOHIS, child impact scale and family impact scores at follow-up (Wilcoxon signedrank test; p ˂ 0.001). There were statistically significant changes in the mean GTR of children's oral health. CONCLUSIONS: A-ECOHIS was sensitive and responsive to SDF treatment. SDF statistically significantly improved the OHRQoL of uncooperative preschool children.


Asunto(s)
Caries Dental , Calidad de Vida , Niño , Preescolar , Ansiedad al Tratamiento Odontológico , Caries Dental/tratamiento farmacológico , Caries Dental/prevención & control , Miedo , Fluoruros Tópicos , Humanos , Salud Bucal , Estudios Prospectivos , Compuestos de Amonio Cuaternario , Compuestos de Plata , Encuestas y Cuestionarios
14.
BMC Oral Health ; 21(1): 35, 2021 01 20.
Artículo en Inglés | MEDLINE | ID: mdl-33472613

RESUMEN

BACKGROUND: Silver diamine fluoride (SDF) is a minimally-invasive preventive service used in the U.S. to avert and arrest caries since 2014. No studies document survival outcomes based in real world delivery. We analyzed 12-month survival outcomes of SDF applied independently or concurrently with other restorative procedures among a population receiving community dental care. METHODS: We analyzed data on SDF applications from de-identified dental claims on Oregon Health Plan patients served by Advantage Dental in 2016, who had been seen in 2015 (patient n = 2269; teeth n = 7787). We compared survival rates of SDF alone, SDF applied with a sedative filling, and SDF with a same-day restoration. Failure was defined as a restoration or extraction of the tooth 7 to 365 days after initial application. Survival was defined as a patient returning 180 or more days after application whose tooth did not have a restoration or extraction. Differences were assessed through Wilcoxon equality of survivor function tests and log-rank equality of survivor tests to compare failure rates, Cox Proportional Hazards models to assess factors associated with survival of SDF, and Kaplan-Meier survival estimate to calculate the probability of survival over time. RESULTS: SDF alone had an overall survival rate of 76%. SDF placed with sedative filling and with a same-day restoration had survival rates of 50% and 84% respectively, likely reflecting treatment intent. SDF alone survived exceptionally well on primary cuspids, permanent molars, and permanent bicuspids and among patients aged 10 to 20 years, with modest variation across caries risk assessment categories. A single annual application of SDF was successful in 75% of cases. Among SDF failures on permanent dentition, more than two-thirds of teeth received a minor restoration. CONCLUSION: SDF is a minimally invasive non-aerosolizing option that prevented non-cavitated lesions and arrested early decay among community dentistry patients when applied independently or concurrently with restorative procedures. Professional organizations, policy makers, providers, and payors should broaden optional SDF use by informing clinical guidelines, reimbursement policies, and treatment decisions. Future research should address clinical, social, service delivery, workforce, and economic outcomes using diverse population-based samples, and the mechanisms underlying single application success and caries prevention potential.


Asunto(s)
Caries Dental , Clínicas Odontológicas , Adolescente , Adulto , Cariostáticos/uso terapéutico , Niño , Caries Dental/tratamiento farmacológico , Caries Dental/prevención & control , Fluoruros Tópicos/uso terapéutico , Humanos , Oregon , Compuestos de Amonio Cuaternario , Compuestos de Plata/uso terapéutico , Adulto Joven
15.
Monogr Oral Sci ; 29: 80-90, 2021.
Artículo en Inglés | MEDLINE | ID: mdl-33427222

RESUMEN

Untreated dental caries is the most prevalent disease worldwide. Development of caries is associated with the intake of sugar. The microorganisms utilize the sugar and create an acidic environment, which results in mineral loss. The appropriate use of fluoride is associated with a decline of caries. Another approach in preventing caries might be the increase of pH in dental plaque. During recent years, arginine has increasingly become the focus of interest. This is based on the fact that certain streptococci possess an arginine deiminase system (ADS) which metabolizes free arginine. In vivo, the incidence of caries was inversely correlated with ADS activity in saliva and dental plaque. ADS is highly active in Streptococcus gordonii and S. sanguinis, but is absent in S. sobrinus and S. mutans. In the presence of 1.5% L-arginine, S. gordonii and S. sanguinis, but not S. mutans and S. sobrinus, synthesize the metabolite citrulline and increase the pH of the environment.In defined multispecies biofilms consisting of ADS-positive and ADS-negative streptococci, supplementation with 1.5% arginine suppressed the growth of ADS-negative by favoring ADS-positive streptococci together with an increase in the pH of the environment. Evaluating the influence of daily manual removal of the biofilm in vitro by brushing with a commercial toothpaste containing fluoride and arginine resulted in less surface microhardness even when compared with a toothpaste with fluoride only. Recent studies clinically investigated the effect of using an arginine-containing dentifrice and reported a decrease of DMFS by about 10-20%.


Asunto(s)
Caries Dental , Arginina , Biopelículas , Caries Dental/prevención & control , Humanos , Streptococcus mutans , Streptococcus sanguis
16.
Quintessence Int ; 0(0): 318-326, 2021.
Artículo en Inglés | MEDLINE | ID: mdl-33491385

RESUMEN

Objective: This study aimed to examine and compare the anti-caries effects of slightly acidic 1% NaF-HF gel when applied once or twice (7-day or 6-month interval) to mandibular first molars in 6- to 7-year-old children. Method and materials: This was a 1-year, multi-arm, placebo-controlled, double-blind, parallel-group randomized trial. In total, 1,077 schoolchildren from eight primary schools were allocated to one of the four study groups (group 1, single application; group 2, two applications with a 7-day interval; group 3, two applications with a 6-month interval; group 4, placebo control). The occlusal surfaces of permanent mandibular first molars were examined by three calibrated examiners who were blind to the group allocation at baseline and the end of the study. Caries reduction and prevented fraction was assessed. Results: A total of 986 children completed the study. There was a statistically significant difference in the mean D1MFT increment across the groups (P < .001). The mean D1MFT increment was 0.37 in group 1 (single application), 0.18 in group 2 (two applications with a 7-day interval), 0.21 in group 3 (two applications with a 6-month interval), and 0.56 in the control group. The mean D2MFT increments (0.22 in group 1, 0.06 in group 2, 0.18 in group 3, and 0.50 in the control group) also showed a statistically significant difference across the groups (P < .001). Conclusion: Subacidic 1% NaF-HF gel exerts a high preventive effect on caries (more than 40%) when applied twice at a 7-day interval in 6- to 7-year-old schoolchildren who do not use fluoride toothpaste in areas where drinking water is not fluoridated.


Asunto(s)
Cariostáticos , Caries Dental , Niño , Caries Dental/prevención & control , Método Doble Ciego , Humanos , Diente Molar , Pastas de Dientes
18.
Arch Oral Biol ; 122: 105022, 2021 Feb.
Artículo en Inglés | MEDLINE | ID: mdl-33418434

RESUMEN

The objective of this study was to perform a comprehensive review of the use of antimicrobial peptides for the prevention and treatment of dental caries. The study included publications in the English language that addressed the use of antimicrobial peptides in the prevention and treatment of caries. These publications were also searchable on PubMed, Web of Science, Embase, Scopus, the Collection of Anti-Microbial Peptides and the Antimicrobial Peptide Database. A total of 3,436 publications were identified, and 67 publications were included. Eight publications reported seven natural human antimicrobial peptides as bactericidal to Streptococcus mutans. Fifty-nine publications reported 43 synthetic antimicrobial peptides developed to mimic natural antimicrobial peptides, fusing peptides with functional sequences and implementing new designs. The 43 synthetic antimicrobial peptides were effective against Streptococcus mutans, and nine peptides specifically targeted Streptococcus mutans. Ten antimicrobial peptides had an affinity for hydroxyapatite to prevent bacterial adhesion. Six antimicrobial peptides were also antifungal. Four antimicrobial peptides promoted remineralisation or prevented the demineralisation of teeth by binding calcium to hydroxyapatite. In conclusion, this study identified 67 works in the literature that reported seven natural and 43 synthetic antimicrobial peptides for the prevention and treatment of caries. Most of the antimicrobial peptides were bactericidal, and some prevented bacterial adhesion. A few antimicrobial peptides displayed remineralising properties with hydroxyapatite.


Asunto(s)
Antibacterianos/uso terapéutico , Caries Dental , Proteínas Citotóxicas Formadoras de Poros/uso terapéutico , Adhesión Bacteriana/efectos de los fármacos , Biopelículas , Caries Dental/tratamiento farmacológico , Caries Dental/prevención & control , Durapatita , Humanos , Streptococcus mutans/efectos de los fármacos , Remineralización Dental
19.
Mol Oral Microbiol ; 36(1): 67-79, 2021 02.
Artículo en Inglés | MEDLINE | ID: mdl-33316854

RESUMEN

Ligustrum robustum (Roxb.) Blume is utilized as a traditional Chinese herbal tea with various health benefits and protective effects. Streptococcus mutans is an important cariogenic oral bacteria species. The present study aimed to assess the influence of Ligustrum robustum extract (LRE) on the biofilm formation of S. mutans and the mechanism of its action, as well as to identify its chemical components. For chemical identification, HPLC-MS and nuclear magnetic resonance were applied and four identified phytochemicals were reported (Ligurobustoside B, Ligurobustoside N, Ligurobustoside J, and Ligurobustoside C). The dose-dependent (0.5 to 2.0 µg/µL) antimicrobial toxicity of LRE against S. mutans biofilm formation and exopolysaccharide (EPS) synthesis was evaluated by confocal laser scanning microscopy (CLSM), Crystal violet stain, and CFU counting. The microstructure of S. mutans biofilm treated with LRE was investigated both on glass coverslips and ex vivo bovine dental enamel by scanning electron microscopy (SEM). Moreover, LRE downregulated the expression of S. mutans glucosyltransferase-encoding genes gtfB, gtfC, and gtfD, and the quorum sensing (QS) factors comD and comE, suggesting its toxic mechanism. In addition, the result of CCK-8 test on human oral cells revealed an acceptable biocompatibility of LRE. These findings indicated the possible application of this daily consumed herbal tea for caries prevention.


Asunto(s)
Caries Dental , Ligustrum , Animales , Biopelículas , Bovinos , Caries Dental/prevención & control , Humanos , Extractos Vegetales/farmacología , Streptococcus mutans
20.
Artículo en Inglés | MEDLINE | ID: mdl-33348756

RESUMEN

The present study aimed to evaluate the effect of the oral-hygiene regime on the incidence of enamel demineralization in young patients treated with fixed appliances. Research was conducted in a group of 144 patients aged 12-18 years, divided into 2 groups: orthodontically treated and control. The study was divided into three stages: before treatment (I), at 1 month (II), and at 6 months (III) for their follow-up. The International Caries Detection and Assessment System (ICDAS) was used for the visual assessment of white spot lesions (WSL). After 1 month, no new white spot lesions were observed. After 6 months of the treatment, new lesions were observed in 5% of the orthodontically treated patients and in 6% of the patients in the control group. New decalcifications were located on the proximal surfaces of the central incisors, first premolars, and first molars in the orthodontically treated group; and on the lateral incisors, first premolars, and first molars in the control group. We also observed new enamel demineralization on the vestibular surfaces of the canine and first premolar in the study group. The placement of a fixed appliance did not significantly affect teeth with the presence of new white spot lesions compared to the control group during 6 months of observation.


Asunto(s)
Caries Dental , Higiene Bucal , Aparatos Ortodóncicos Fijos , Adolescente , Estudios de Casos y Controles , Niño , Caries Dental/epidemiología , Caries Dental/prevención & control , Humanos , Incidencia , Higiene Bucal/normas , Aparatos Ortodóncicos Fijos/efectos adversos
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