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1.
Life Sci ; 244: 117339, 2020 Mar 01.
Artículo en Inglés | MEDLINE | ID: mdl-31972210

RESUMEN

AIM: Despite recent advances in therapeutic strategies, cancer is still a leading cause of mortality worldwide. Mitochondrial dysfunction is implicated in cancer initiation and metastasis, and even in chemo- and radio-resistance. However, the precise role of mitochondria in cancer is crosstalk and controversial. This study is trying to find out the effect of transferring normal mitochondria into the highly aggressive and proliferative MDA-MB-231 cancer cells, and to evaluate the effect of the transfer with/without a combination therapy with cisplatin. MATERIALS AND METHODS: Normal mitochondria were isolated from human umbilical cord derived-mesenchymal stem cells. The mitochondria were transferred into the MDA-MB-231 cells, and also into cells with mitochondrial dysfunction induced by rhodamine red 6 (R6G). Cell proliferation and sensitivity of the cells to cisplatin were measured by cell counting after the mitochondria transfer. Also, apoptosis was evaluated by DAPI staining and in situ cell death detection (TdT-mediated dUTP nickend labeling; TUNEL) methods. Migration capability of the cells was studied by transwell assay. KEY FINDINGS: Transfer of normal mitochondria into MDA-MB-231 cells increased cell proliferation. However, the transfer of mitochondria enhanced cisplatin-induced apoptosis in MDA-MB-231 cells in which mitochondria were already disrupted. Introduction of normal cell-derived mitochondria into the MDA-MB-231 cells increased their invasive, but decreased the migration potency of the cells in the group with mitochondrial dysfunction (MDA + RG6 + Cisplatin). CONCLUSION: The introduction of healthy mitochondria to highly aggressive and proliferative cells would be considered as a new therapeutic modality for some types of cancer.


Asunto(s)
Neoplasias de la Mama/patología , Movimiento Celular/efectos de los fármacos , Proliferación Celular/efectos de los fármacos , Cisplatino/farmacología , Células Madre Mesenquimatosas/patología , Mitocondrias/patología , Cordón Umbilical/patología , Antineoplásicos/farmacología , Apoptosis/efectos de los fármacos , Neoplasias de la Mama/tratamiento farmacológico , Femenino , Humanos , Células Madre Mesenquimatosas/efectos de los fármacos , Mitocondrias/efectos de los fármacos , Células Tumorales Cultivadas , Cordón Umbilical/efectos de los fármacos
2.
Orv Hetil ; 160(48): 1894-1903, 2019 Dec.
Artículo en Húngaro | MEDLINE | ID: mdl-31760773

RESUMEN

Introduction: According to the Hungarian law, placental examination is not mandatory, although it is known from the international practice that it can give valuable information in cases of stillbirth or in conditions, where the neonate has difficulty in the postnatal adaptation. Aim: It can be useful in the early detection of diseases, which otherwise would have gone undetected until late in life. This article is unique in Hungary, as no similar guideline exists in Hungarian language. Method: The recommendation of the Royal College of Pathologists (United Kingdom) determines those conditions where essential information can be obtained from the placental examination in not normal pregnancies. It serves as a useful guide in the medical practice. The journal titled "Placenta", first published in 1980 with impact factor above two, just underlines this statement. Results: In this article, the authors present the recent guideline of the RCPath and finish with the presentation of established clinicopathological association that might help clinicians to get the most valuable information from placental examination. Conclusion: The present article aims to summarise updated recommendations and present clinicopathological correlations. Orv Hetil. 2019; 160(48): 1894-1903.


Asunto(s)
Placenta/patología , Guías de Práctica Clínica como Asunto , Mortinato , Femenino , Humanos , Hungría , Recién Nacido , Embarazo , Sociedades Médicas , Cordón Umbilical/patología , Reino Unido
4.
Pathologica ; 111(1): 13-17, 2019 03.
Artículo en Inglés | MEDLINE | ID: mdl-31217617

RESUMEN

Umbilical cord hemangioma is an uncommon benign vascular neoplasm arising from the free segment of the umbilical cord, distinct from placental and fetal insertion, and is thought to originate from endothelial cells of the umbilical vessels. Cystic changes in the umbilical cord rarely occur as a consequence of the damage to the amnionic surface of the cord caused by the presence of the hemangioma. Until now, a total of 8 cases of umbilical cord hemangioma associated with cystic changes in the umbilical cord have been reported in the literature, however, among these cases, only one showed an associated cyst derived from inclusion of the amniotic epithelium, and the remaining seven cases consisted of hemangiomas with associated pseudocyst of the umbilical cord. We herein report a case of umbilical cord hemangioma with an associated amnionic epithelial inclusion cyst. Clinicopathological features and differential diagnostic considerations are also discussed.


Asunto(s)
Amnios/patología , Quistes , Hemangioma , Neoplasias Primarias Múltiples , Complicaciones Neoplásicas del Embarazo , Cordón Umbilical/irrigación sanguínea , Cordón Umbilical/patología , Adulto , Quistes/diagnóstico , Quistes/patología , Diagnóstico Diferencial , Femenino , Hemangioma/diagnóstico , Hemangioma/patología , Humanos , Embarazo
5.
Int J Mol Sci ; 20(8)2019 Apr 25.
Artículo en Inglés | MEDLINE | ID: mdl-31027199

RESUMEN

Preeclampsia (PE) has been associated with placental dysfunction, resulting in fetal hypoxia, accelerated erythropoiesis, and increased erythroblast count in the umbilical cord blood (UCB). Although the detailed effects remain unknown, placental dysfunction can also cause inflammation, nutritional, and oxidative stress in the fetus that can affect erythropoiesis. Here, we compared the expression of surface adhesion molecules and the erythroid differentiation capacity of UCB hematopoietic stem/progenitor cells (HSPCs), UCB erythroid profiles along with the transcriptome and proteome of these cells between male and female fetuses from PE and normotensive pregnancies. While no significant differences were observed in UCB HSPC migration/homing and in vitro erythroid colony differentiation, the UCB HSPC transcriptome and the proteomic profile of the in vitro differentiated erythroid cells differed between PE vs. normotensive samples. Accordingly, despite the absence of significant differences in the UCB erythroid populations in male or female fetuses from PE or normotensive pregnancies, transcriptional changes were observed during erythropoiesis, particularly affecting male fetuses. Pathway analysis suggested deregulation in the mammalian target of rapamycin complex 1/AMP-activated protein kinase (mTORC1/AMPK) signaling pathways controlling cell cycle, differentiation, and protein synthesis. These results associate PE with transcriptional and proteomic changes in fetal HSPCs and erythroid cells that may underlie the higher erythroblast count in the UCB in PE.


Asunto(s)
Células Eritroides/metabolismo , Feto/patología , Preeclampsia/genética , Proteómica , Caracteres Sexuales , Transcripción Genética , Diferenciación Celular/genética , Movimiento Celular/genética , Eritropoyesis/genética , Femenino , Regulación de la Expresión Génica , Células Madre Hematopoyéticas/metabolismo , Humanos , Masculino , Preeclampsia/patología , Embarazo , Resultado del Embarazo/genética , Biosíntesis de Proteínas , Transcriptoma/genética , Cordón Umbilical/patología
6.
Biomed Res Int ; 2019: 9185059, 2019.
Artículo en Inglés | MEDLINE | ID: mdl-30886867

RESUMEN

Introduction: Umbilical cord milking is a procedure in which clamped or unclamped umbilical cord is grasped, and blood is pushed ("stripped") two to four times towards the newborn, in a rapid time frame, usually within 20 seconds. The target of umbilical cord milking is to provide infants with their whole potential blood volume-of which they are deprived when early cord clamping is carried out-completing placental transfusion in a shorter time than delayed cord clamping. The aim of this narrative review is to analyse the literature regarding umbilical cord milking in term and late-preterm infants and to assess all possible benefits and limits of this procedure in clinical practice, especially in comparison to immediate and delayed cord clamping. Methods: We analysed literature data concerning maternal, as well as neonatal, outcomes for term and late-preterm (gestational age ≥ 34 weeks) newborns who received umbilical cord milking. Results: Most studies show comparable benefits for both umbilical cord milking and delayed cord clamping, especially in terms of haematological parameters when compared to immediate cord clamping. Umbilical cord milking may be a feasible procedure also for newborns requiring resuscitation. Conclusions: Literature data concerning positive effects of umbilical cord milking are encouraging and suggest that umbilical cord milking may be a quick and effective method to provide placental transfusions to depressed infants. However, the lack of standardised procedures and the variation in evaluated outcomes as well as the limited number of patients enrolled in trials, along with the retrospective nature of some of them, prevent recommending umbilical cord milking as a routine procedure.


Asunto(s)
Recien Nacido Prematuro/sangre , Nacimiento Prematuro/sangre , Cordón Umbilical/irrigación sanguínea , Transfusión Sanguínea , Femenino , Edad Gestacional , Humanos , Lactante , Recién Nacido , Embarazo , Nacimiento Prematuro/fisiopatología , Nacimiento a Término , Cordón Umbilical/patología
7.
Int Immunopharmacol ; 71: 68-75, 2019 Jun.
Artículo en Inglés | MEDLINE | ID: mdl-30877876

RESUMEN

Acute lung injury (ALI), a persistent lung inflammatory response syndrome, may evolve into acute respiratory distress syndrome (ARDS). Characterized by rapid onset, critical features, and a complex etiology, ALI remains a challenging critical respiratory disease. Recently, mesenchymal stem cells (MSCs) have provided a new solution for the treatment of ALI. We built a lipopolysaccharide (LPS)-induced ALI model in mice. After treatment with human umbilical cord mesenchymal stem cells (hUC-MSCs), FTY720, or a combination of hUC-MSCs and FTY207, the lung inflammatory response was apparently attenuated. To understand the mechanism underlying MSCs treatment of ALI at the genetic level, significant differentially expressed long non-coding RNAs (lncRNAs) between the treatment and model groups were analyzed using microarray technology. Moreover, genetic gene prediction, gene ontology (GO) analysis, pathway analysis, and transcription factor (TF) prediction were carried out. The results showed that a total of 66 lncRNAs were differentially expressed in all three treatment groups, including 8 up-regulated and 58 down-regulated lncRNAs. LncRNA A_30_P01029806 and A_30_P01029194, which were down-regulated, were involved in the signaling pathways closely related to ALI. Through further TF analysis, we identified several significant TFs which lay a foundation for revealing the mechanism underlying lncRNAs treatment of ALI. LncRNA A_30_P01029806 and A_30_P01029194 may serve as candidate biomarkers in the diagnosis and treatment of ALI.


Asunto(s)
Lesión Pulmonar Aguda/terapia , Clorhidrato de Fingolimod/uso terapéutico , Inmunosupresores/uso terapéutico , Pulmón/fisiología , Células Madre Mesenquimatosas/fisiología , Neumonía/terapia , ARN Largo no Codificante/genética , Animales , Terapia Combinada , Modelos Animales de Enfermedad , Regulación de la Expresión Génica , Ontología de Genes , Humanos , Lipopolisacáridos/inmunología , Masculino , Trasplante de Células Madre Mesenquimatosas , Ratones , Ratones Endogámicos C57BL , Neumonía/inmunología , Transducción de Señal/genética , Cordón Umbilical/patología
9.
J Clin Ultrasound ; 47(6): 366-368, 2019 Jul.
Artículo en Inglés | MEDLINE | ID: mdl-30673136

RESUMEN

We report a case of a prenatally detected hemangioma of the umbilical cord as an early sign of diffuse neonatal hemangiomatosis (DNH). The newborn was diagnosed with multiple hemangiomas in the liver, intestines, skin, and brain. Prenatal ultrasound findings, neonatal appearance of the hemangiomas, and the associated complications are illustrated. Interdisciplinary investigations as well as operative and systemic treatment approaches proved to be challenging. This case illustrates how prenatal ultrasound with color Doppler facilitates the early diagnosis of DNH and can help through the early referral to specialized centers for appropriate treatment.


Asunto(s)
Hemangioma/diagnóstico por imagen , Hemangioma/embriología , Ultrasonografía Prenatal/métodos , Cordón Umbilical/diagnóstico por imagen , Neoplasias Vasculares/diagnóstico por imagen , Neoplasias Vasculares/embriología , Adulto , Diagnóstico Diferencial , Femenino , Hemangioma/patología , Humanos , Embarazo , Ultrasonografía Doppler en Color , Cordón Umbilical/embriología , Cordón Umbilical/patología , Neoplasias Vasculares/patología
10.
J Matern Fetal Neonatal Med ; 32(22): 3824-3829, 2019 Nov.
Artículo en Inglés | MEDLINE | ID: mdl-29732948

RESUMEN

Objective: To verify the relationship between the time of clamping of the umbilical cord and the development of neonatal jaundice, the dosage of bilirubin and the need for phototherapy. Methods: Cross-sectional, retrospective study with 398 parturients at normal risk (single term gestation, no complications during gestation or delivery, birth weight between 2500 and 4499 g). The population was divided into three groups regarding the time of cord clamping: <1 min(117, 29.4%), between 1 and 3 min(228, 57.3%) and >3 min(53, 13.3%). Sociodemographic, clinical and obstetric characteristics, birth and delivery data, and maternal and perinatal outcomes were evaluated. Pearson's chi-square test, Fisher's exact test and the Kruskal-Wallis test were used for comparison between the groups. Statistical significance was considered p < .05. Results: The groups were similar in the development of jaundice (p = .370), bilirubin dosage (p = .342) and need for phototherapy (p = .515). Late clamping was more prevalent in vaginal deliveries when compared to cesarean sections (1-3 min: 64 versus 21.4%, >3 min: 16.6 versus 1%) (p < .001). There was no difference in other maternal or perinatal variables. Conclusion: The clamping time of the umbilical cord showed no association with jaundice, bilirubin dosage, or phototherapy needs in neonates at normal risk. The adoption of late clamping was more prevalent in vaginal deliveries.


Asunto(s)
Parto Obstétrico , Ictericia Neonatal/epidemiología , Ictericia Neonatal/terapia , Fototerapia/estadística & datos numéricos , Instrumentos Quirúrgicos , Cordón Umbilical/cirugía , Adolescente , Adulto , Constricción , Estudios Transversales , Parto Obstétrico/efectos adversos , Parto Obstétrico/instrumentación , Parto Obstétrico/métodos , Parto Obstétrico/estadística & datos numéricos , Femenino , Edad Gestacional , Humanos , Recién Nacido , Ictericia Neonatal/etiología , Embarazo , Estudios Retrospectivos , Factores de Riesgo , Instrumentos Quirúrgicos/efectos adversos , Instrumentos Quirúrgicos/estadística & datos numéricos , Cordón Umbilical/patología , Adulto Joven
11.
J Matern Fetal Neonatal Med ; 32(22): 3723-3728, 2019 Nov.
Artículo en Inglés | MEDLINE | ID: mdl-29712515

RESUMEN

Objective: This study compares the effect of starting intravenous oxytocin infusion early before uterine incision versus late after umbilical cord clamping on the blood loss during elective cesarean section (CS). Methods: A single-blinded randomized clinical trial conducted on 200 pregnant women at term (>37 weeks) gestation scheduled for elective CS were assigned to either IV infusion of 30 IU of oxytocin started before uterine incision (Group I) or started immediately after clamping the umbilical cord (Group II). The primary outcome was the mean volume of blood loss during CS. The secondary outcomes included the mean volume of postoperative blood loss, the mean reduction in the hemoglobin and hematocrit levels, the need for additional uterotonics, blood transfusion and additional surgical procedures. Results: The baseline characteristics of both groups are quiet similar. No statistical significant difference between both groups as regard to pre- and postpartum hemoglobin levels (p = .06 and 0.24 respectively) and hematocrit values (p = .12 and .51 respectively). There was a significant reduction in the intraoperative blood loss in group I compared with group II (432.7 ± 90.6 versus 588.9 ± 96.3 mL respectively, p = .001). The need for additional uterotonics was more frequent in the group II (19 women) than in group I (seven women) with statistical significance (p = .002). No differences between both groups regarding the need for blood transfusion or additional surgical procedures. Conclusions: Initiating intravenous oxytocin infusion before uterine incision during elective CS could be associated with reduction in the intraoperative blood loss and the need for additional uterotonics.


Asunto(s)
Pérdida de Sangre Quirúrgica/prevención & control , Cesárea/métodos , Oxitocina/administración & dosificación , Adulto , Cesárea/efectos adversos , Constricción , Procedimientos Quirúrgicos Electivos , Femenino , Humanos , Infusiones Intravenosas , Oxitocina/farmacología , Hemorragia Posparto/prevención & control , Embarazo , Resultado del Embarazo , Instrumentos Quirúrgicos , Nacimiento a Término/efectos de los fármacos , Nacimiento a Término/fisiología , Cordón Umbilical/patología , Cordón Umbilical/cirugía , Adulto Joven
13.
Pediatr Dev Pathol ; 22(4): 279-287, 2019.
Artículo en Inglés | MEDLINE | ID: mdl-30541420

RESUMEN

The objective of this study is to better understand embryonic vitelline vascular remnants in the umbilical cord, to assess their prevalence, to categorize their morphology, and then finally to describe and assess inflammation arising from these structures. During routine placental sign out, the author noted the presence or absence of vitelline vessel remnants for 1 year; when present, he assessed their histologic patterns and noted whether there were neutrophils marginating from the remnants and into the adjacent Wharton's jelly and whether there was any other evidence of amniotic fluid infection in sections of placental disc, membranes, or cord. All cord sections with vitelline vessel remnants were immunostained for CD15 to document any infiltrates, to highlight patterns of infiltration, and to evaluate whether mild cases of umbilical phlebitis were associated with these lesions and were at risk of being missed. Vitelline vessel remnants were present in 4.2% of placentas examined. There were 5 vitelline vessel remnant histologic patterns identified providing insight into the vitelline vessel circulation. Funisitis, primarily neutrophilic, arising from vitelline vessel remnants was present in 70.3% of the 37 cords with vitelline vessel remnants. The presence of vitelline vessel remnant funisitis documents continued active circulation in these vascular structures, and vitelline vessel remnant funisitis was associated with the presence of other placental histological evidence of amniotic fluid infection in 53.8% of cases. The author also reviews normal embryology and the pathology of vitelline vessel remnants.


Asunto(s)
Líquido Amniótico/microbiología , Corioamnionitis/patología , Inflamación/patología , Cordón Umbilical/patología , Alberta/epidemiología , Vasos Sanguíneos/embriología , Vasos Sanguíneos/patología , Corioamnionitis/epidemiología , Corioamnionitis/microbiología , Femenino , Humanos , Inflamación/microbiología , Neutrófilos/patología , Placenta/microbiología , Placenta/patología , Embarazo , Estudios Prospectivos , Cordón Umbilical/microbiología , Conducto Vitelino/patología
14.
Pediatr Dev Pathol ; 22(4): 288-291, 2019.
Artículo en Inglés | MEDLINE | ID: mdl-30541421

RESUMEN

The aim of this study was to examine the prevalence of embryologic remnants in umbilical cords of different gestational ages. Sections from 392 umbilical cords were examined using light microscopy. Of these, 52% contained at least 1 remnant, most commonly of the allantoic duct type. Although there was a significant decrease in vitelline duct remnants over increasing gestational age, from 11% at weeks 11-25 to 1.6% at weeks 36-42 (P = .009; χ2 test), the allantoic duct remnants remained constant in prevalence irrespective of gestational age.


Asunto(s)
Edad Gestacional , Cordón Umbilical/patología , Factores de Edad , Alantoides/patología , Femenino , Humanos , Embarazo , Conducto Vitelino/patología
15.
J Matern Fetal Neonatal Med ; 32(6): 954-960, 2019 Mar.
Artículo en Inglés | MEDLINE | ID: mdl-29065736

RESUMEN

AIM: The aim of this study was to investigate the possible maternal and fetal factors, which affect the Umbilical Coiling Index (UCI). METHODS: This prospective, observational, analytic study was conducted using the data of 380 women with term pregnancy and newborns who presented at a University Hospital. Hemoglobin (Hb), ferritin, iron, and the total iron binding capacity (TIBC) of the maternal blood were measured, and transferrin saturation was estimated based on the ratio between serum iron and TIBC. Blood gases, ferritin, iron, and TIBC of the umbilical cord were also measured, and the transferrin saturation was calculated. The length and thickness of the umbilical cord, numbers of coilings, weight of placenta, neonatal weight were registered. The UCI was calculated dividing the total number of coils by the length of the umbilical cord (in cm). RESULTS: A positive, linear, and statistically significant relationship was found between the UCI scores and the umbilical cord blood transferrin saturation, umbilical cord thickness, and the first- and fifth-min APGAR scores (p = .044, p < .001, p = .008, p = .022, respectively). No statistically significant relationship was found between the maternal Hb values and the UCI scores (p = .472). In addition, there was no statistically significant relationship between the UCI scores and maternal ferritin, maternal transferrin saturation and umbilical cordon ferritin levels (p = .940, p = .681, and p = .975, respectively). CONCLUSIONS: A positive correlation was found between the UCI and umbilical cord transferrin saturation and between the newborn APGAR scores. However, this finding is not sufficient to explain the relationship of the umbilical cord dynamics with the newborn wellbeing and coiling.


Asunto(s)
Cordón Nucal/patología , Transferrina/metabolismo , Cordón Umbilical/patología , Adulto , Puntaje de Apgar , Peso al Nacer , Femenino , Humanos , Recién Nacido , Persona de Mediana Edad , Cordón Nucal/etiología , Placenta/patología , Embarazo , Resultado del Embarazo , Estudios Prospectivos , Ultrasonografía Prenatal , Cordón Umbilical/diagnóstico por imagen , Adulto Joven
17.
Biochem Biophys Res Commun ; 508(4): 1149-1154, 2019 01 22.
Artículo en Inglés | MEDLINE | ID: mdl-30554659

RESUMEN

Diabetes in pregnancy constitutes an unfavorable environment for embryonic and fetal development, where the child has a higher risk of perinatal morbidity and mortality, with high incidence of congenital malformations and predisposition to long-term metabolic diseases that increase with a hypercaloric diet. To analyze whether hyperglycemia differentially affects proliferation, apoptosis, and mRNA expression in cells from children of normoglycemic pregnancies (NGPs) and diabetes mellitus pregnancies (DMPs), we used umbilical cord Wharton jelly cells as a research model. Proliferation assays were performed to analyze growth and determine the doubling time, and the rate of apoptosis was determined by flow cytometry-annexin-V assays. AMPK, BNIP3, HIF1α, and p53 mRNA gene expression was assessed by semi-quantitative RT-PCR. We found that hyperglycemia decreased proliferation in a statistically significant manner in NGP cells treated with 40 mM D-glucose and in DMP cells treated with 30 and 40 mM D-glucose. Apoptosis increased in hyperglycemic conditions in NGP and DMP cells. mRNA expression of BNIP3 and p53 was significantly increased in cells from DMPs but not in cells from NGPs. We found evidence that maternal irregular metabolic conditions, like diabetes with hyperglycemia in culture, affect biological properties of fetal cells. These observations could be a constituent of fetal programming.


Asunto(s)
Apoptosis/genética , Hiperglucemia/genética , Proteínas de la Membrana/genética , Embarazo en Diabéticas/genética , Embarazo en Diabéticas/patología , Proteínas Proto-Oncogénicas/genética , Proteína p53 Supresora de Tumor/genética , Cordón Umbilical/patología , Gelatina de Wharton/metabolismo , Adenilato Quinasa/genética , Adenilato Quinasa/metabolismo , Proliferación Celular/genética , Femenino , Humanos , Subunidad alfa del Factor 1 Inducible por Hipoxia/genética , Subunidad alfa del Factor 1 Inducible por Hipoxia/metabolismo , Proteínas de la Membrana/metabolismo , Embarazo , Proteínas Proto-Oncogénicas/metabolismo , ARN Mensajero/metabolismo , Proteína p53 Supresora de Tumor/metabolismo
19.
J Perinatol ; 38(12): 1620-1624, 2018 12.
Artículo en Inglés | MEDLINE | ID: mdl-30323323

RESUMEN

OBJECTIVE: Determine the association between electronic fetal monitoring and neonatal outcomes in the setting of a true knot at delivery. STUDY DESIGN: This was a planned secondary analysis of a prospective cohort of 8580 women. Patients with and without a true knot were compared and the primary outcome was repetitive late decelerations occurring with at least 50% of contractions. Confounders were adjusted for using logistic regression. RESULTS: A total of 8580 patients met inclusion criteria and 49 (0.57%) had a TK. There was no significant difference in the rate of repetitive late decelerations in patients with TK (aOR 1.04; 95% confidence interval [CI] 0.25-4.40),other electronic fetal monitoring parameters, or neonatal outcomes. CONCLUSION: Neonates with true knots who are delivered at term have similar electronic fetal monitoring characteristics compared to those without true knots and no detectable difference in neonatal morbidity; thus, calling into question the clinical significance of a true knot at term.


Asunto(s)
Cardiotocografía , Cordón Umbilical/patología , Adulto , Femenino , Frecuencia Cardíaca Fetal , Humanos , Recién Nacido , Trabajo de Parto , Modelos Logísticos , Morbilidad , Embarazo , Resultado del Embarazo , Estudios Prospectivos , Adulto Joven
20.
Fetal Pediatr Pathol ; 37(5): 359-362, 2018 Oct.
Artículo en Inglés | MEDLINE | ID: mdl-30339043

RESUMEN

PURPOSE: Short umbilical cords are associated with adverse perinatal outcomes. Clinicians may rely on measurements made by pathologists, which do not include portions of the cord remaining n the child or sent for blood gasses. METHODS: This was a retrospective chart review of term placentas. Sequential cases from January through August 2017 were reviewed from the Pathology archive. RESULTS: 198 placentas were recorded as either third trimester of mature, of which 146 were 37 or greater weeks of gestation. Of these 146, 142 had cords measuring less than 35 cm, the definition of short. Mean cord length was 19.6 cm. Of the 146 placentas, 50(34%) had had blood gases submitted. CONCLUSIONS: 34% of short cords by Pathology measurement had had blood gases sent. The fact that 142 out of 146 sequential placentas were recorded as "short" suggests an additional unmeasured loss of length due to cord attached to the infant. Pathology laboratory measurements should not be interpreted as truly short without clinical correlation.


Asunto(s)
Patología Clínica/métodos , Cordón Umbilical/patología , Análisis de los Gases de la Sangre/métodos , Humanos , Estudios Retrospectivos
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