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1.
J Med Microbiol ; 69(1): 132-138, 2020 Jan.
Artículo en Inglés | MEDLINE | ID: mdl-31859618

RESUMEN

Introduction. The bacterial pathogen, Pseudomonas syringae pv. actinidiae (Psa), has emerged as a major threat to kiwifruit cultivation throughout the world. One pandemic strain (from the Psa3 group) has occurred in various geographical regions. It is important to understand how this pathogen is being transmitted.Aim. Although Psa has been found in Korea since 1992, the isolates were until recently of a distinct type (Psa2). Recently, the more virulent Psa3 type has been detected. The purpose of this study was to describe the variety of Psa3 now found in Korea.Methodology. Strains were isolated from kiwifruit plants in Korea and from pollen imported into Korea from New Zealand. The genomes of 10 isolates were sequenced using the Illumina platform and compared to the completely assembled genomes of pandemic Psa3 strains from New Zealand and China. Comparisons were also made with pandemic strains from Chile and non-pandemic Psa3 isolates from China.Results. Six of the 10 Psa3 isolates from Korea show a clear relationship with New Zealand isolates. Two isolates show a distinct relationship to isolates from Chile; one further isolate has a sequence that is highly similar to that of M228, a strain previously isolated in China; and the last isolate belongs to the Psa3 group, but is not a member of the pandemic lineage.Conclusion. This analysis establishes that there have been multiple routes of transmission of the Psa3 pandemic strain into Korea. One route has involved the importation of pollen from New Zealand. A second route probably involves importation from Chile.


Asunto(s)
Actinidia/microbiología , Genotipo , Enfermedades de las Plantas/microbiología , Polen/microbiología , Pseudomonas syringae/clasificación , Pseudomonas syringae/aislamiento & purificación , Secuenciación Completa del Genoma , Corea (Geográfico) , Pseudomonas syringae/genética
2.
BMC Cancer ; 19(1): 952, 2019 Oct 15.
Artículo en Inglés | MEDLINE | ID: mdl-31615457

RESUMEN

BACKGROUND: Lymph-node (LN) metastasis is an important prognostic factor in resected pancreatic cancer. In this study, the prognostic value of American Joint Committee on Cancer (AJCC) 8th edition N stage, lymph-node ratio (LNR), and log odds of positive lymph nodes (LODDS) in resected pancreatic cancer was investigated. METHODS: Between January 2005 and December 2017, there were 351 patients with pancreatic cancer treated with R0 resection and adjuvant therapy at Seoul National University Hospital. Relationships between the three LN parameters and overall survival (OS) and recurrence-free survival (RFS) were evaluated using a log-rank test and Cox proportional hazard regression model. Each multivariate-adjusted LN parameter was internally validated by bootstrap-corrected Harrell's C-index. RESULTS: The mean duration from surgery to adjuvant therapy was 47.6 ± 17.4 days. In total, the median OS and RFS was 31.7 (95% CI, 27.2-37.2) and 15.4 (95% CI, 13.5-17.7) months. The three LN classification systems were significantly correlated with OS and RFS in log-rank tests and multivariate-adjusted models (all p < 0.05). When internally validated, LNR showed the highest discrimination ability in predicting OS and RFS (each C-index = 0.65). LNR also showed the highest C-index in subgroup analysis, classified by adjuvant therapy modality. LNR and the AJCC 8th edition LN classification system were significantly associated with loco-regional recurrence (p = 0.026 and p = 0.027, respectively). CONCLUSIONS: LNR, which showed the best prognostic performance and significant relationship with loco-regional recurrence, can help further stratify the patients and establish an active treatment plan.


Asunto(s)
Quimioterapia Adyuvante , Escisión del Ganglio Linfático , Neoplasias Pancreáticas/terapia , Radioterapia Ayuvante , Anciano , Supervivencia sin Enfermedad , Femenino , Estudios de Seguimiento , Hospitales Universitarios , Humanos , Estimación de Kaplan-Meier , Corea (Geográfico) , Metástasis Linfática , Masculino , Persona de Mediana Edad , Recurrencia Local de Neoplasia , Pronóstico , Modelos de Riesgos Proporcionales
3.
Int J Mol Sci ; 20(19)2019 Sep 20.
Artículo en Inglés | MEDLINE | ID: mdl-31547213

RESUMEN

Symplocarpus, a skunk cabbage genus, includes two sister groups, which are drastically different in life history traits and thermogenesis, as follows: The nonthermogenic summer flowering S. nipponicus and thermogenic early spring flowering S. renifolius. Although the molecular basis of thermogenesis and complete chloroplast genome (plastome) of thermogenic S. renifolius have been well characterized, very little is known for that of S. nipponicus. We sequenced the complete plastomes of S. nipponicus sampled from Japan and Korea and compared them with that of S. renifolius sampled from Korea. The nonthermogenic S. nipponicus plastomes from Japan and Korea had 158,322 and 158,508 base pairs, respectively, which were slightly shorter than the thermogenic plastome of S. renifolius. No structural or content rearrangements between the species pairs were found. Six highly variable noncoding regions (psbC/trnS, petA/psbJ, trnS/trnG, trnC/petN, ycf4/cemA, and rpl3/rpl22) were identified between S. nipponicus and S. renifolius and 14 hot-spot regions were also identified at the subfamily level. We found a similar total number of SSR (simple sequence repeat) motifs in two accessions of S. nipponicus sampled from Japan and Korea. Phylogenetic analysis supported the basal position of subfamily Orontioideae and the monophyly of genus Symplocarpus, and also revealed an unexpected evolutionary relationship between S. nipponicus and S. renifolius.


Asunto(s)
Araceae , ADN de Plantas/genética , Genoma de Plastidios , Filogenia , Araceae/clasificación , Araceae/genética , Japón , Corea (Geográfico) , Especificidad de la Especie
4.
Int Arch Allergy Immunol ; 180(3): 195-201, 2019.
Artículo en Inglés | MEDLINE | ID: mdl-31505505

RESUMEN

BACKGROUND: Previous studies have used serum periostin levels as a biomarker of Th2-driven inflammatory responses. However, no population-based study has yet examined the association of serum periostin levels with the allergic status of children. OBJECTIVES: The aim of this study was to determine the usefulness of periostin as a biomarker for allergy in a group of 7-year-old Korean children. METHOD: This prospective cross-sectional study examined 451 children (aged 7 years to 7 years and 11 months) from the general pediatric population who attended 6 different schools between June and July 2016. A total of 249 children, all of whom completed the questionnaire and skin prick test and provided blood samples, were included in the final analysis. RESULTS: The geometric mean serum periostin level was 107.6 ng/mL (95% CI 104.5-110.7). After adjustment for confounding, serum periostin levels were significantly associated with sensitization to poly-allergens (adjusted odds ratio, aOR 1.032, 95% CI 1.006-1.059, p = 0.016) and pollen (aOR 1.020, 95% CI 1.002-1.039, p = 0.026). Serum periostin levels were also associated with eosinophil levels (adjusted ß = 0.023, SE = 0.009, p = 0.010), but were unrelated to body mass index, sex, obesity, or presence of an allergic disease. CONCLUSIONS: Our results suggest thatserum periostin level may have limited usefulness as a biomarker of allergic disease in children.


Asunto(s)
Biomarcadores/sangre , Moléculas de Adhesión Celular/sangre , Eosinófilos/inmunología , Hipersensibilidad/diagnóstico , Inmunización/estadística & datos numéricos , Alérgenos/inmunología , Niño , Estudios Transversales , Femenino , Humanos , Hipersensibilidad/epidemiología , Corea (Geográfico)/epidemiología , Masculino , Grupos de Población , Estudios Prospectivos , Pruebas Cutáneas
5.
Pharm. pract. (Granada, Internet) ; 17(3): 0-0, jul.-sept. 2019. tab
Artículo en Inglés | IBECS | ID: ibc-ET1-4331

RESUMEN

This review focuses on the studies and opinions around issues of transition from the BPharm to the PharmD degree in the U.S., Japan, South Korea, Pakistan and Thailand. The transition to the clinically orientated PharmD degree in many countries was seen to be a means of developing the profession. However, some countries have both clinically-oriented and pharmaceutical sciences-oriented PharmD programme that are designed to meet the needs of their countries. Each country created a different process to handle the transition to an all-PharmD programme, but mostly had the process of school accreditation mandated by the regulatory bodies. The main barrier to the transition in most of the countries was the issue of educational quality. A set of indicators is needed to measure and monitor the impact/outcome of the PharmD degree. Each country has different needs due to the different contexts of health care systems and the scope of pharmacy practice. In order to increase their chances of benefiting from the new programme, academic leaders should critically assess their countries' needs before deciding to adopt a PharmD programme


No disponible


Asunto(s)
Humanos , Administración Farmacéutica/clasificación , Servicios Farmacéuticos/clasificación , Centros Farmacéuticos , Farmacia/clasificación , Competencia Profesional , Educación en Farmacia/tendencias , Curriculum/tendencias , Estados Unidos , Japón , Corea (Geográfico) , Pakistán , Tailandia
6.
Food Chem Toxicol ; 133: 110729, 2019 Nov.
Artículo en Inglés | MEDLINE | ID: mdl-31381944

RESUMEN

The present study aimed to develop a consortium of nutritive fermented food products, supplemented with phytochemicals, with reduced toxicological contents. We developed new flavored Doenjang products (protein rich) fermented with lotus, ginkgo, and garlic plant extract-based Meju (termed as EMD) as the starter culture and by using traditional Meju (termed as TMD), where these plant extracts were added later during the fermentation process. Fermented Doenjang samples were analyzed for reduced levels of biogenic amines (BAs), aflatoxins, and microbial hazards, (including Bacillus cereus) as well as for their nutritive contents and antioxidant potential, after varying periods of fermentation (0, 3, 6, 9 and 12 months). All Doenjang samples prepared using plant extracts and their mixtures (1% and 10%) showed desired reduction in B. cereus counts, BAs, aflatoxins, and other foodborne pathogens as well as showed potent antioxidant abilities, including phenolic/flavonoid contents. Based on the higher efficiency in reducing various toxicants, Ginkgo biloba leaf extract added TMD samples were selected for the development of Doenjang products as an innovative approach, with great potential to improve the quality and safety of soybean fermented products in the Korean market, offering enhanced health benefits and reduced risks of toxicity.


Asunto(s)
Aflatoxinas/análisis , Carga Bacteriana , Aminas Biogénicas/análisis , Extractos Vegetales/análisis , Alimentos de Soja/análisis , Bacillus cereus/aislamiento & purificación , Línea Celular , Color , Fermentación , Microbiología de Alimentos/métodos , Calidad de los Alimentos , Depuradores de Radicales Libres/análisis , Ajo/química , Ginkgo biloba/química , Humanos , Concentración de Iones de Hidrógeno , Corea (Geográfico) , Lotus/química , Alimentos de Soja/microbiología , Soja/química , Soja/microbiología
7.
Helicobacter ; 24(5): e12646, 2019 Oct.
Artículo en Inglés | MEDLINE | ID: mdl-31368629

RESUMEN

BACKGROUND: The Helicobacter pylori eradication rate has decreased with increasing antibiotic resistance. We conducted a prospective, nationwide, multicenter registry study to monitor the real status of H. pylori eradication therapy and to investigate the association between eradication success and antibiotic use density in Korea. MATERIALS AND METHODS: We enrolled 9318 patients undergoing H. pylori eradication therapy from 37 hospitals through "on-line database registry" from October 2010 to July 2015. Demographic data, detection methods, treatment indications, regimens, durations, compliance, adverse events, and eradication results were collected. The use of all commercially available eradication antibiotics was analyzed through the Korean National Health Insurance data of the Health Insurance Review and Assessment Service. The defined daily dose of antibiotics was used to standardize drug use comparisons. RESULTS: Finally, 6738 patients were analyzed. The overall eradication rate of first-line therapy was 71.8%. The eradication success rates were 71.7%, 86.9%, and 74.0% for standard triple therapy for 7 days, quadruple therapy, and concomitant therapy, respectively. The eradication success rate in naive patients was higher than that in those who previously underwent H. pylori eradication. Eradication success was significantly associated with younger age, female sex, and high compliance. Regional differences in eradication rates were observed. The yearly use density of clarithromycin increased statistically in seven regions across the country from 2010 to 2015. The yearly use density of amoxicillin in the Gyeongsang and Chungcheong areas was significantly increased (P < .01), whereas that of other macrolides was significantly lower in the Gyeonggi area than in other areas (P = .01). The overall use of eradication antibiotics has increased while the eradication rate steadily decreased for 5 years. However, there was no significant correlation between antibiotic use density and eradication. CONCLUSION: There was no relationship between the eradication rate and antibiotic use density in Korea.


Asunto(s)
Antibacterianos/uso terapéutico , Bases de Datos Factuales , Utilización de Medicamentos/estadística & datos numéricos , Infecciones por Helicobacter/tratamiento farmacológico , Infecciones por Helicobacter/epidemiología , Internet , Sistema de Registros , Adulto , Anciano , Anciano de 80 o más Años , Femenino , Humanos , Corea (Geográfico)/epidemiología , Masculino , Persona de Mediana Edad , Estudios Prospectivos , Resultado del Tratamiento
8.
J Hosp Infect ; 103(3): 276-279, 2019 Nov.
Artículo en Inglés | MEDLINE | ID: mdl-31319094

RESUMEN

Since 2011, 2% chlorhexidine in 70% isopropyl alcohol (2% chlorhexidine tincture) has been widely used in Korea. To investigate changes in chlorhexidine sensitivity of staphylococci causing central line-associated bloodstream infections, 264 blood culture isolates from adult patients treated in intensive care units of five university hospitals between 2008 and 2016 were analysed. We observed no significant changes in chlorhexidine minimum inhibitory and bactericidal concentrations, or in the prevalence of resistance-associated genes before and after introduction of 2% chlorhexidine tincture. Thus, there was no evidence of increased resistance to chlorhexidine in staphylococci causing central line-associated bloodstream infections.


Asunto(s)
Bacteriemia/microbiología , Infecciones Relacionadas con Catéteres/microbiología , Clorhexidina/farmacología , Desinfectantes/farmacología , Infecciones Estafilocócicas/microbiología , Staphylococcus/efectos de los fármacos , Adulto , Anciano , Anciano de 80 o más Años , Cateterismo Venoso Central/efectos adversos , Femenino , Humanos , Unidades de Cuidados Intensivos , Corea (Geográfico) , Masculino , Pruebas de Sensibilidad Microbiana , Persona de Mediana Edad , Staphylococcus/aislamiento & purificación
9.
Cardiology ; 142(4): 224-231, 2019.
Artículo en Inglés | MEDLINE | ID: mdl-31302649

RESUMEN

BACKGROUND: Elevated blood pressure (BP) is a component of the metabolic syndrome (MetS), and one third of individuals with hypertension simultaneously have MetS. However, the evidence is still unclear regarding the predictive ability of BP for incident MetS. METHODS: In total, 5,809 Koreans without baseline MetS were grouped by baseline systolic (SBP) and diastolic BP (DBP) and monitored for 10 years to identify incident MetS. A Cox proportional hazards model was used to evaluate the HR and 95% CI for MetS according to SBP and DBP. Subgroup analysis was conducted in the normotensive population based on a new guideline of the American College of Cardiology and the American Heart Association. RESULTS: High-BP groups tended to have worse metabolic profiles than the lowest-BP group in both SBP and DBP categories. In all of the participants, elevated SBP and DBP levels were significantly associated with the increased HR for MetS, even after adjusting for covariates. Subgroup analysis for normotensive participants indicated that the HR for MetS increased proportionally to both SBP (<110 mm Hg: reference, 110-119 mm Hg: HR = 1.60 [95% CI 1.40-1.84], and 120-129 mm Hg: HR = 2.12 [95% CI 1.82-2.48]) and DBP levels (<70 mm Hg: reference, 71-74 mm Hg: HR = 1.31 [95% CI 1.09-1.58], and 75-79 mm Hg: HR = 1.51 [95% CI 1.25-1.81]). CONCLUSION: The risk of incident MetS increased proportionally to baseline SBP and DBP, and this was identically observed even in normotensive participants.


Asunto(s)
Hipertensión/complicaciones , Síndrome Metabólico/complicaciones , Síndrome Metabólico/epidemiología , Adulto , Anciano , Presión Sanguínea , Femenino , Frecuencia Cardíaca/fisiología , Humanos , Incidencia , Corea (Geográfico)/epidemiología , Masculino , Persona de Mediana Edad , Factores de Riesgo , Distribución por Sexo , Encuestas y Cuestionarios
10.
Semin Ophthalmol ; 34(5): 353-358, 2019.
Artículo en Inglés | MEDLINE | ID: mdl-31165650

RESUMEN

Purpose: To investigate the clinical characteristics of perifoveal exudative vascular anomalous complex (PEVAC) in Korean patients. Methods: This retrospective study included 8 eyes (8 patients) diagnosed with PEVAC. Demographic characteristics of the patients, fundus photography, optical coherence tomography (OCT), fluorescein angiography, and indocyanine-green angiography (ICGA) findings were analyzed. Available follow-up data were also reviewed. Results: The mean ± standard deviation age was 61.0 ± 11.0 years and mean logarithm of minimal angle of resolution (logMAR) best-corrected visual acuity was 0.15 ± 0.14. PEVAC was noted in 2 eyes with coincident age-related macular degeneration (AMD) and in the fellow eye of 1 eye with unilateral type 3 neovascularization. On fundus photography, PEVAC presented as a perifoveal isolated aneurysm associated with retinal exudation and hemorrhage. Well-defined hyperfluorescent lesions with leakage were noted on fluorescein angiography, but no leakage was observed on ICGA. Anti-vascular endothelial growth factor (VEGF) therapy was performed for 2 patients. However, there was no notable improvement after treatment. Conclusions: The clinical characteristics of PEVAC in Korean patients were similar to those reported in patients of other ethnicities. Further studies are needed to better understand the nature of this newly described clinical entity.


Asunto(s)
Fóvea Central/patología , Enfermedades de la Retina , Vasos Retinianos/anomalías , Malformaciones Vasculares , Adulto , Anciano , Exudados y Transudados , Femenino , Humanos , Corea (Geográfico) , Masculino , Persona de Mediana Edad , Enfermedades de la Retina/patología , Enfermedades de la Retina/fisiopatología , Neovascularización Retiniana/patología , Neovascularización Retiniana/fisiopatología , Estudios Retrospectivos , Malformaciones Vasculares/patología , Malformaciones Vasculares/fisiopatología , Agudeza Visual
11.
Antonie Van Leeuwenhoek ; 112(10): 1559-1565, 2019 Oct.
Artículo en Inglés | MEDLINE | ID: mdl-31172329

RESUMEN

A Gram-stain negative, non-motile, and yellow-coloured bacterium, designated 17J28-26T, was isolated from soil in Jeju Island, Korea. Phylogenetic analyses based on 16S rRNA gene sequences revealed that strain 17J28-26T formed a distinct lineage within the family Chitinophagaceae (order Chitinophagales, class Chitinophagia), and is closely related to Flavisolibacter ginsenosidimutans (96.8% 16S rRNA gene sequence similarity), and Flavisolibacter ginsengisoli (96.6%). Growth was observed at 18-37 °C (optimum 30 °C) in R2A medium at pH 7.0. The major cellular fatty acids of strain 17J28-26T were summed feature 3 (C16:1 ω6c and/or C16:1 ω7c), and iso-C15:0. The predominant respiratory quinone was MK-7. The major polar lipid was identified as phosphatidylethanolamine. Based on biochemical, chemotaxonomic and phylogenetic characteristics, strain 17J28-26T represents a novel bacterial species within the family Chitinophagaceae, for which the name Flavisolibacter galbus sp. nov. is proposed. The type strain of Flavisolibacter galbus is 17J28-26T (= KCTC 62222T = JCM 33203T).


Asunto(s)
Bacteroidetes/clasificación , Bacteroidetes/aislamiento & purificación , Microbiología del Suelo , Bacteroidetes/genética , Bacteroidetes/fisiología , Análisis por Conglomerados , Citosol/química , ADN Bacteriano/química , ADN Bacteriano/genética , ADN Ribosómico/química , ADN Ribosómico/genética , Ácidos Grasos/análisis , Concentración de Iones de Hidrógeno , Islas , Corea (Geográfico) , Locomoción , Fosfolípidos/análisis , Filogenia , Pigmentos Biológicos/metabolismo , Quinonas/análisis , ARN Ribosómico 16S/genética , Análisis de Secuencia de ADN , Temperatura
12.
Diabetes Res Clin Pract ; 153: 76-85, 2019 Jul.
Artículo en Inglés | MEDLINE | ID: mdl-31152805

RESUMEN

AIMS: Serotonin, or 5-hydroxytryptamine (5-HT), and serotonin receptor (HTR) subtypes contribute to controlling energy homeostasis. We investigated the association of polymorphisms of serotonin related genes with type 2 diabetes in Korean adults using a community-based prospective cohort study. METHODS: A total of 8840 participants (4205 Ansung, 4635 Ansan) from the Korean Genome and Epidemiology Study (KoGES)-Ansan and Ansung were included. The mean follow-up duration was 7.6 years, and the Ansan and Ansung cohorts were treated as independent replicates. Individuals with existing and new-onset type 2 diabetes were identified at baseline and follow-up evaluations, respectively. Logistic regression analysis was used to evaluate the association of 3402 single nucleotide polymorphisms (SNPs) in serotonin related genes with type 2 diabetes after adjusting for baseline age, sex, body mass index, drinking status, and smoking status. RESULTS: The baseline case-control comparison revealed significant association of 26 SNPs in HTR3B and HTR2A with type 2 diabetes. Interestingly, HTR3B SNP rs1176744, which is involved in behavioral disorders, was associated with type 2 diabetes (p-value = 0.0002). Furthermore, HTR3B polymorphisms that significantly associated with type 2 diabetes were located in the 3' downstream region. The new-onset type 2 diabetes case-control study revealed significant association of 3 additional SNPs of the HTR4. CONCLUSIONS: We found that rs1176744 in HTR3B was associated with type 2 diabetes. Additionally, our study suggests that polymorphisms in the downstream region of HTR3B may contribute to the development of type 2 diabetes.


Asunto(s)
Diabetes Mellitus Tipo 2/epidemiología , Genómica/métodos , Polimorfismo Genético/genética , Receptores de Serotonina/genética , Adulto , Anciano , Estudios de Casos y Controles , Femenino , Humanos , Corea (Geográfico) , Masculino , Persona de Mediana Edad , Estudios Prospectivos , Adulto Joven
13.
Mycopathologia ; 184(3): 423-431, 2019 Jun.
Artículo en Inglés | MEDLINE | ID: mdl-31147870

RESUMEN

BACKGROUND: Chronic rhinosinusitis (CRS) with eosinophilic mucin is considered rare in Korea. The object of this study was to categorize CRS patients with eosinophilic mucin into several groups and compared the groups based on their clinicopathological and radiological features. METHODS: In total, 105 CRS patients with eosinophilic mucin from four tertiary medical centers which are located at Chungcheong province of Korea were included for this study. The patients were divided into four groups for analysis, based on the presence or absence of an allergy (A) to a fungus or fungal element (F) in the mucin. The following were the four groups: allergic fungal rhinosinusitis (AFRS, A+F+), AFRS-like sinusitis (A+F-), eosinophilic fungal rhinosinusitis (EFRS, A-F+), and eosinophilic mucin rhinosinusitis (EMRS, A-F-). Their clinical manifestation, the presence of associated disease, radiological finding, treatment, and treatment outcome were reviewed and compared. RESULTS: There were no patients in the AFRS-like sinusitis group, 47 patients were assigned to the AFRS group, 27 to the EFRS group, and 41 to the EMRS group. Patients of AFRS group showed a significantly higher association with allergic rhinitis than did the other groups. The mean total serum IgE level in the AFRS patients was significantly higher than in the EFRS and EMRS patients. In the AFRS group and EFRS group, 67.6% and 74.1% had unilateral disease, respectively, in contrast to the EMRS group (4.9%). The mean Hounsfield unit values of the area of high attenuation in the AFRS patients were significantly higher than those in the other groups. CONCLUSIONS: Significant clinicopathological differences existed among the subgroups of CRS with eosinophilic mucin. AFRS tends to be an allergic response to colonizing fungi in atopic individuals. In EFRS, local allergies to fungi might play a role in the disease. EMRS is thought to be unconnected with fungal allergies, and it showed different form compared with the AFRS and EFRS groups.


Asunto(s)
Eosinófilos/inmunología , Mucinas/análisis , Micosis/microbiología , Micosis/patología , Sinusitis/microbiología , Sinusitis/patología , Tomografía Computarizada por Rayos X , Adulto , Enfermedad Crónica , Femenino , Humanos , Inmunoglobulina E/sangre , Corea (Geográfico) , Masculino , Persona de Mediana Edad , Micosis/diagnóstico por imagen , Estudios Retrospectivos , Sinusitis/diagnóstico por imagen , Resultado del Tratamiento
14.
Korean J Parasitol ; 57(2): 175-177, 2019 Apr.
Artículo en Inglés | MEDLINE | ID: mdl-31104410

RESUMEN

A 46-year old man visited our outpatient clinic with complaint of foreign body sensation in throat after consuming raw freshwater fish 5 days ago. Laryngoscopic examination revealed a motile worm attached on posterior pharyngeal wall. The worm was removed using biopsy forceps under transnasal endoscopy and evidently identified as Clinostomum complanatum after microscopic examination. Patient's subjective foreign body sensation of throat and hyperemia of laryngeal mucosa remained for approximately 2 weeks post-removal, which were eventually resolved after administration of non-steroidal anti-inflammatory drug and anti-refluxant drug for 2 weeks. Treatment was ended at three weeks since the first visit. C. complanatum infections in humans are rare, and only four cases have been reported in Korea. Symptoms resembling pharyngitis or laryngitis occurs by consumption of raw, infected freshwater fish and treatment is done by mechanically removing the parasite.


Asunto(s)
Cuerpos Extraños/patología , Faringe/patología , Faringe/parasitología , Trematodos/aislamiento & purificación , Infecciones por Trematodos/diagnóstico , Infecciones por Trematodos/patología , Animales , Antiinflamatorios/administración & dosificación , Endoscopía/métodos , Humanos , Corea (Geográfico) , Masculino , Microscopía , Persona de Mediana Edad , Esteroides/administración & dosificación , Resultado del Tratamiento , Trematodos/anatomía & histología , Infecciones por Trematodos/parasitología , Infecciones por Trematodos/terapia
15.
Mycoses ; 62(7): 609-616, 2019 Jul.
Artículo en Inglés | MEDLINE | ID: mdl-30980768

RESUMEN

BACKGROUND: Tinea capitis (TC) is a dermatophyte infection involving hair and scalp and occurs primarily in prepubertal children. However, data on adults are limited. OBJECTIVES: The aim of this study was to evaluate epidemiological, clinical and mycological characteristics of TC in adults in Korea. PATIENTS/METHODS: We retrospectively evaluated 82 adults (44.3%) among 185 TC patients at a tertiary hospital during June 2000-2017. RESULTS: Mean patient age was 66.9 ± 15.8 (20-90) years with female predominance; mean disease duration until mycological diagnosis, 22.5 (1-144) weeks; and misdiagnosis rate, 65.9%. Most common presumptive initial diagnoses were seborrhoeic dermatitis (24.4%) and bacterial folliculitis (18.3%). Chronic systemic illness and accompanying alopecia were found in 61 (74.4%) and 46 (56.1%) patients, respectively. Pustular type was found in 26.8% patients, followed by seborrhoeic dermatitis-like 25.6%, grey patch 23.2%, kerion celsi 22.0% and black dot 2.4%. Forty-eight patients (58.5%) had tinea infection at other skin areas. Microsporum canis (56.5%) and Trichophyton rubrum (21.7%) were the most common causative organisms; 92.7% patients achieved complete resolution, and seven patients (9.2%) had a recurrence. CONCLUSIONS: We report the largest, most recent series of case studies of adult TC. Adult TC is not an uncommon problem, especially in elderly women, and has distinctive epidemiological and clinicomycological characteristics compared to those in prepubertal children. Recognising adult TC profile will help clinicians avoid misdiagnosis and provide appropriate treatment.


Asunto(s)
Hongos/aislamiento & purificación , Tiña del Cuero Cabelludo/epidemiología , Tiña del Cuero Cabelludo/patología , Adulto , Anciano , Anciano de 80 o más Años , Femenino , Humanos , Corea (Geográfico)/epidemiología , Masculino , Persona de Mediana Edad , Estudios Retrospectivos , Centros de Atención Terciaria , Tiña del Cuero Cabelludo/microbiología , Adulto Joven
16.
Artículo en Inglés | MEDLINE | ID: mdl-30987355

RESUMEN

An association between exposure to air pollution and liver enzymes in certain areas or older people has been reported in the literature; however, it cannot be generalized to the general population. We investigated the association between air pollution, liver enzyme levels, and alcohol consumption using nationwide data of South Korean adults. Air pollutants included particulate matter with an aerodynamic diameter ≤10 µm (PM10), nitrogen dioxide (NO2), sulfur dioxide (SO2), and carbon monoxide (CO). Liver enzymes included alanine aminotransferase (ALT) and aspartate aminotransferase (AST). Exposure to air pollutants were significantly associated with elevation of log ALT and log AST, especially increases from 0.0073 IU/L (95% confidence interval (CI) = 0.0042, 0.0104) to 0.0251 IU/L (95% CI = 0.0132, 0.0371) per interquartile range (IQR) increase of each pollutant (all pollutants: p < 0.001). Association of the liver enzymes with PM10 (ß (95% CI) = 0.0285 IU/L (0.0201, 0.0368) for log ALT; ß (95% CI) = 0.0139 IU/L (0.0079, 0.0198) for log AST) and CO (ß (95% CI) = 0.0247 IU/L (0.0182, 0.0311) for log ALT; ß (95% CI) = 0.0164 IU/L (0.0118, 0.0210) for log AST) were only significant among drinkers. Our findings suggest that chronic exposure to PM10 and CO is a risk factor for liver enzymes increases among the general adult population who admitted to drinking alcohol.


Asunto(s)
Contaminación del Aire/efectos adversos , Alanina Transaminasa/metabolismo , Aspartato Aminotransferasas/metabolismo , Exposición a Riesgos Ambientales/efectos adversos , Hígado/efectos de los fármacos , Hígado/enzimología , Adulto , Anciano , Contaminantes Atmosféricos/análisis , Contaminación del Aire/análisis , Consumo de Bebidas Alcohólicas/epidemiología , Exposición a Riesgos Ambientales/análisis , Femenino , Humanos , Corea (Geográfico)/epidemiología , Masculino , Persona de Mediana Edad , Encuestas Nutricionales , Material Particulado/análisis , Factores de Riesgo
17.
Korean J Parasitol ; 57(1): 21-25, 2019 Feb.
Artículo en Inglés | MEDLINE | ID: mdl-30840795

RESUMEN

Trichomoniasis is the most common curable sexually-transmitted infection. Most Trichomonas vaginalis-infected men are asymptomatic and can remain undiagnosed and untreated, and this has been thought to result in chronic persistent prostatic infection. Chronic inflammation is regarded as the major factor in the pathogenesis and progression of benign prostatic hyperplasia (BPH) and prostatic cancer (PCa). The aim of this study is to identify seropositivity to T. vaginalis in men with prostate tumors (BPH or PCa) visited to Hanyang University Hospital. A total of 183 men were enrolled between October 2013 and November 2014. They consisted of 139 with BPH (mean age: 64.0 ± 0.07) and 44 with prostate cancer (mean age: 73.3±0.18). We carried out ELISA to identify the seropositivity to T. vaginalis. Mixed lysate antigen extracted from 8 strains of T. vaginalis was used in the ELISA. Also 58 male outpatients visited to Health Promotion Center in Hanyang University Hospital were evaluated for comparing group. As a results, seropositivity to T. vaginalis in patients with prostatic diseases was 19.7% (BPH: 18.7%, PCa: 22.7%) and it was significantly higher than the 1.7% of the comparing healthy group (P = 0.001). Therefore, prostatic tumor showed higher seropositivity against T. vaginalis than normal men. As far as we know, this is the first report about seroprevalence in prostatic tumor in Korea.


Asunto(s)
Neoplasias de la Próstata/complicaciones , Tricomoniasis/epidemiología , Trichomonas vaginalis/inmunología , Anciano , Anciano de 80 o más Años , Ensayo de Inmunoadsorción Enzimática , Hospitales Universitarios , Humanos , Corea (Geográfico)/epidemiología , Masculino , Persona de Mediana Edad , República de Corea/epidemiología , Estudios Seroepidemiológicos , Adulto Joven
18.
Korean J Parasitol ; 57(1): 17-20, 2019 Feb.
Artículo en Inglés | MEDLINE | ID: mdl-30840794

RESUMEN

A stray female cat of unknown age, presenting bright red watery diarrhea, was submitted to the Animal and Plant Quarantine Agency for diagnosis. In the small intestines extracted from the necropsied cat, numerous white oval-shaped organisms were firmly embedded in the mucosa and there was thickening of intestinal wall. Histopathological analysis revealed severe necrotizing enteritis, together with atrophied intestinal villi, exfoliated enterocytes, and parasitic worms. Recovered worms were identified as Pharyngostomum cordatum by morphological observation and genetic analysis. Although P. cordatum is known to occur widely in Korea, this is the first clinical description of an infection by P. cordatum causing severe feline enteritis.


Asunto(s)
Enfermedades de los Gatos/diagnóstico , Enfermedades de los Gatos/patología , Diarrea/veterinaria , Enterocolitis Necrotizante/veterinaria , Trematodos/aislamiento & purificación , Infecciones por Trematodos/veterinaria , Animales , Enfermedades de los Gatos/parasitología , Gatos , Diarrea/diagnóstico , Diarrea/parasitología , Diarrea/patología , Enterocolitis Necrotizante/diagnóstico , Enterocolitis Necrotizante/parasitología , Enterocolitis Necrotizante/patología , Femenino , Histocitoquímica , Mucosa Intestinal/parasitología , Mucosa Intestinal/patología , Intestino Delgado/parasitología , Intestino Delgado/patología , Corea (Geográfico) , Trematodos/anatomía & histología , Trematodos/genética , Infecciones por Trematodos/diagnóstico , Infecciones por Trematodos/parasitología , Infecciones por Trematodos/patología
19.
Diagn Microbiol Infect Dis ; 94(2): 183-187, 2019 Jun.
Artículo en Inglés | MEDLINE | ID: mdl-30713116

RESUMEN

This study aimed to characterize patients with monomicrobial gram-negative necrotizing fasciitis in three university hospitals in Korea. In this study, of the 115 patients with community-acquired necrotizing fasciitis, 67 (58%) had monomicrobial infections: 31 (27%) in the gram-negative group and 36 (31%) in the gram-positive group. The majority of patients in the gram-negative group were infected with Escherichia coli followed by Klebsiella pneumoniae and Vibrio vulnificus. More patients in the gram-negative group showed liver cirrhosis than those in the gram-positive group (39% vs. 14%, P = 0.02). In a multivariable logistic regression analysis, liver cirrhosis (adjusted odds ratio [aOR], 13.7; 95% confidence interval [CI], 2.9-67.0), treatment with antibiotics without surgery (aOR, 10.2; 95% CI, 2.1-48.3), and lower level of albumin (aOR 4.9; 95% CI, 1.6-14.9) were associated with 30-day mortality. Our findings suggest that gram-negative necrotizing fasciitis is more often associated with liver cirrhosis and has poorer outcomes than gram-positive necrotizing fasciitis.


Asunto(s)
Fascitis Necrotizante/patología , Bacterias Gramnegativas/aislamiento & purificación , Infecciones por Bacterias Gramnegativas/patología , Infecciones Comunitarias Adquiridas/epidemiología , Infecciones Comunitarias Adquiridas/microbiología , Infecciones Comunitarias Adquiridas/mortalidad , Infecciones Comunitarias Adquiridas/patología , Fascitis Necrotizante/mortalidad , Bacterias Gramnegativas/clasificación , Infecciones por Bacterias Gramnegativas/epidemiología , Infecciones por Bacterias Gramnegativas/microbiología , Infecciones por Bacterias Gramnegativas/mortalidad , Bacterias Grampositivas/clasificación , Bacterias Grampositivas/aislamiento & purificación , Infecciones por Bacterias Grampositivas/epidemiología , Infecciones por Bacterias Grampositivas/microbiología , Hospitales Universitarios , Humanos , Corea (Geográfico)/epidemiología , Factores de Riesgo , Análisis de Supervivencia
20.
Virology ; 530: 11-18, 2019 04.
Artículo en Inglés | MEDLINE | ID: mdl-30753976

RESUMEN

H5Nx clade 2.3.4.4 highly pathogenic avian influenza viruses (HPAIVs) have been disseminated to wide geographic regions since 2014. In 2016, five distinct genotypes (C-1 to C-5) of clade 2.3.4.4c H5N6 HPAIVs were detected in South Korea. In this study, we evaluated the pathogenicity, susceptibility to infection, and transmissibility of the two strains representing the C-1 and C-4 genotypes of the H5N6 viruses, which have different PA and NS gene, in domestic ducks. Although the susceptibility to infection of domestic ducks to the two strains was similar, the C-4 genotype virus induced higher mortality in ducks than C-1 genotype virus. A higher titer of viral shedding were detected in ducks challenged with the C-4 genotype virus compared with the C-1 genotype virus. These results indicated that the reassortment of HPAIVs with prevailing low pathogenic avian influenza viruses could effect on the pathogenicity in ducks.


Asunto(s)
Patos/virología , Virus de la Influenza A/aislamiento & purificación , Virus de la Influenza A/patogenicidad , Gripe Aviar/virología , ARN Replicasa/genética , Proteínas no Estructurales Virales/genética , Proteínas Virales/genética , Animales , Variación Genética , Virus de la Influenza A/clasificación , Virus de la Influenza A/genética , Gripe Aviar/mortalidad , Gripe Aviar/transmisión , Corea (Geográfico) , Análisis de Supervivencia , Esparcimiento de Virus
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