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1.
Front Immunol ; 15: 1393799, 2024.
Artículo en Inglés | MEDLINE | ID: mdl-38975347

RESUMEN

SOCS are a family of negative inhibitors of the molecular cascades induced by cytokines, growth factors and hormones. At molecular level, SOCS proteins inhibit the kinase activity of specific sets of receptor-associated Janus Activated Kinases (JAKs), thereby suppressing the propagation of intracellular signals. Of the eight known members, SOCS1 and SOCS3 inhibit activity of JAKs mainly induced by cytokines and can play key roles in regulation of inflammatory and immune responses. SOCS1 and SOCS3 are the most well-characterized SOCS members in skin inflammatory diseases, where their inhibitory activity on cytokine activated JAKs and consequent anti-inflammatory action has been widely investigated in epidermal keratinocytes. Structurally, SOCS1 and SOCS3 share the presence of a N-terminal domain containing a kinase inhibitory region (KIR) motif able to act as a pseudo-substrate for JAK and to inhibit its activity. During the last decades, the design and employment of SOCS1 and SOCS3-derived peptides mimicking KIR domains in experimental models of dermatoses definitively established a strong anti-inflammatory and ameliorative impact of JAK inhibition on skin inflammatory responses. Herein, we discuss the importance of the findings collected in the past on SOCS1 and SOCS3 function in the inflammatory responses associated to skin immune-mediated diseases and malignancies, for the development of the JAK inhibitor drugs. Among them, different JAK inhibitors have been introduced in the clinical practice for treatment of atopic dermatitis and psoriasis, and others are being investigated for skin diseases like alopecia areata and vitiligo.


Asunto(s)
Transformación Celular Neoplásica , Proteína 1 Supresora de la Señalización de Citocinas , Proteína 3 Supresora de la Señalización de Citocinas , Humanos , Proteína 1 Supresora de la Señalización de Citocinas/metabolismo , Animales , Proteína 3 Supresora de la Señalización de Citocinas/metabolismo , Transformación Celular Neoplásica/inmunología , Transformación Celular Neoplásica/metabolismo , Transducción de Señal , Neoplasias Cutáneas/inmunología , Neoplasias Cutáneas/metabolismo , Neoplasias Cutáneas/patología , Dermatitis/inmunología , Dermatitis/metabolismo , Quinasas Janus/metabolismo , Piel/inmunología , Piel/patología , Piel/metabolismo
2.
Wound Manag Prev ; 70(2)2024 Jun.
Artículo en Inglés | MEDLINE | ID: mdl-38959349

RESUMEN

PURPOSE: This study aimed to assess nursing students' knowledge levels and attitudes towards the etiology, risk factors, and preventive measures of incontinence-associated dermatitis (IAD) using an escape room game. DESIGN: A mixed-method study. SUBJECTS AND SETTING: The sample size of the study was 32 students. METHODS: Quantitative data obtained with the Knowledge, Attitude and Practice of Nurses in Managing Incontinence-Associated Dermatitis Questionnaire (KAP-IAD-Q) and qualitative data obtained through FGDs following the Consolidated Criteria for Reporting Qualitative Research (COREQ) checklist were analyzed using a thematic approach. RESULTS: The average age of the participants was 22.63 ± 0.90, 87.5% of them were female (n=28), and 50% were third (n=16) and fourth-year students (n=16). KAP-IAD-Q total posttest score (88.06+7.00) was found to be high. Data obtained from the FGDs were categorized under 3 main themes: main focus areas during participation in the IAD-themed escape room game; advantages and disadvantages of teamwork in IAD management; and the game's contribution to a better understanding and classification of IAD. CONCLUSIONS: The use of the escape room game facilitated high, fast, and efficient learning of IAD knowledge and attitudes. It revealed challenges in collaborative decision-making, accurate diagnosis, distinguishing from other wounds, and attitude development in the management of IAD.


Asunto(s)
Conocimientos, Actitudes y Práctica en Salud , Estudiantes de Enfermería , Incontinencia Urinaria , Humanos , Estudiantes de Enfermería/psicología , Estudiantes de Enfermería/estadística & datos numéricos , Femenino , Masculino , Encuestas y Cuestionarios , Incontinencia Urinaria/complicaciones , Incontinencia Urinaria/enfermería , Incontinencia Urinaria/psicología , Investigación Cualitativa , Dermatitis/etiología , Dermatitis/psicología , Incontinencia Fecal/complicaciones , Incontinencia Fecal/psicología , Incontinencia Fecal/enfermería , Bachillerato en Enfermería/métodos , Adulto Joven , Competencia Clínica/estadística & datos numéricos , Competencia Clínica/normas
3.
Dermatol Online J ; 30(2)2024 Apr 15.
Artículo en Inglés | MEDLINE | ID: mdl-38959929

RESUMEN

Cutaneous granulomatous reactions are diverse, both from the clinical and the pathological perspective. Most underlying pathophysiological aspects remain elusive. Interstitial granulomatous dermatitis and palisaded neutrophilic and granulomatous dermatitis have been claimed to be reactions to systemic disorders, such as infectious, inflammatory, or neoplastic conditions. Recently, the overarching term "reactive granulomatous dermatitis" has been coined to unify both entities. We herein report two cases of reactive granulomatous dermatitis presenting with the widely known, albeit infrequent "rope sign" and provide clinicopathological correlation. The two patients included a 53-year-old woman with enlarging erythematous plaques and underlying palpable cords on both sides of trunk near axillae (rope sign), and a 51-year-old woman with personal history of rheumatoid arthritis and a palpable cord on the left aspect of the trunk. Pathological findings were compatible with reactive granulomatous dermatitis in both cases. In conclusion, the rope sign represents a strikingly infrequent but decisive diagnostic clue of reactive granulomatous dermatitis.


Asunto(s)
Granuloma , Humanos , Femenino , Persona de Mediana Edad , Granuloma/patología , Granuloma/diagnóstico , Dermatitis/patología , Dermatitis/diagnóstico
6.
Int Wound J ; 21(6): e14936, 2024 Jun.
Artículo en Inglés | MEDLINE | ID: mdl-38899615

RESUMEN

The study aimed to evaluate the effect of an intervention on the prevalence and severity of incontinence-associated dermatitis (IAD) in six hospitals in one state in Australia. This quasi-experimental pre-and post-study, conducted in 18 wards, was part of a larger implementation science study on incontinence-associated dermatitis. Skin and incontinence assessments were conducted on patients during February and March 2020 (pre-intervention) and July and August 2021 (post-intervention). The intervention comprised continence assessment and management, an education brochure for patients, family and caregivers on IAD, the Ghent Global IAD Categorisation Tool (GLOBIAD) and a skin care regime with patient skin protection measures (three-in-one barrier cream cloths, minimisation of bed protection layers, use of appropriate continence aid). A total of 1897 patients were assessed (pre-intervention = 964, post-intervention = 933). A total of 343 (35.6%) pre-intervention patients and 351 (37.6%) post-intervention patients had incontinence. The prevalence of hospital-acquired IAD was 6.71% in the pre-intervention group and 4.27% in the post-intervention group; a reduction of 36.3% (p = 0.159) despite higher patient acuity, prevalence of double incontinence and the COVID-19 pandemic in the post-intervention group compared with the pre-intervention group. Our multisite best practice IAD prevention and treatment intervention was able to reduce the prevalence and severity of hospital-acquired IAD, suggesting enduring effectiveness of the intervention.


Asunto(s)
Dermatitis , Incontinencia Fecal , Incontinencia Urinaria , Humanos , Femenino , Masculino , Incontinencia Urinaria/complicaciones , Incontinencia Urinaria/epidemiología , Prevalencia , Anciano , Incontinencia Fecal/complicaciones , Anciano de 80 o más Años , Dermatitis/etiología , Dermatitis/prevención & control , Dermatitis/epidemiología , Australia/epidemiología , Persona de Mediana Edad , Cuidados de la Piel/métodos , Investigación Biomédica Traslacional , Paquetes de Atención al Paciente/métodos
7.
Int J Mol Sci ; 25(11)2024 May 27.
Artículo en Inglés | MEDLINE | ID: mdl-38891997

RESUMEN

Inflammatory skin diseases highlight inflammation as a central driver of skin pathologies, involving a multiplicity of mediators and cell types, including immune and non-immune cells. Adenosine, a ubiquitous endogenous immune modulator, generated from adenosine triphosphate (ATP), acts via four G protein-coupled receptors (A1, A2A, A2B, and A3). Given the widespread expression of those receptors and their regulatory effects on multiple immune signaling pathways, targeting adenosine receptors emerges as a compelling strategy for anti-inflammatory intervention. Animal models of psoriasis, contact hypersensitivity (CHS), and other dermatitis have elucidated the involvement of adenosine receptors in the pathogenesis of these conditions. Targeting adenosine receptors is effective in attenuating inflammation and remodeling the epidermal structure, potentially showing synergistic effects with fewer adverse effects when combined with conventional therapies. What is noteworthy are the promising outcomes observed with A2A agonists in animal models and ongoing clinical trials investigating A3 agonists, underscoring a potential therapeutic approach for the management of inflammatory skin disorders.


Asunto(s)
Adenosina , Receptores Purinérgicos P1 , Humanos , Animales , Adenosina/metabolismo , Receptores Purinérgicos P1/metabolismo , Enfermedades de la Piel/tratamiento farmacológico , Enfermedades de la Piel/metabolismo , Dermatitis/metabolismo , Dermatitis/tratamiento farmacológico , Dermatitis/patología , Dermatitis/etiología , Inflamación/metabolismo , Inflamación/tratamiento farmacológico , Inflamación/patología , Psoriasis/tratamiento farmacológico , Psoriasis/metabolismo , Transducción de Señal , Antiinflamatorios/uso terapéutico
9.
J Exp Med ; 221(8)2024 Aug 05.
Artículo en Inglés | MEDLINE | ID: mdl-38861030

RESUMEN

Germline gain-of-function (GOF) variants in STAT3 cause an inborn error of immunity associated with early-onset poly-autoimmunity and immune dysregulation. To study tissue-specific immune dysregulation, we used a mouse model carrying a missense variant (p.G421R) that causes human disease. We observed spontaneous and imiquimod (IMQ)-induced skin inflammation associated with cell-intrinsic local Th17 responses in STAT3 GOF mice. CD4+ T cells were sufficient to drive skin inflammation and showed increased Il22 expression in expanded clones. Certain aspects of disease, including increased epidermal thickness, also required the presence of STAT3 GOF in epithelial cells. Treatment with a JAK inhibitor improved skin disease without affecting local Th17 recruitment and cytokine production. These findings collectively support the involvement of Th17 responses in the development of organ-specific immune dysregulation in STAT3 GOF and suggest that the presence of STAT3 GOF in tissues is important for disease and can be targeted with JAK inhibition.


Asunto(s)
Mutación con Ganancia de Función , Imiquimod , Factor de Transcripción STAT3 , Células Th17 , Animales , Factor de Transcripción STAT3/metabolismo , Factor de Transcripción STAT3/genética , Células Th17/inmunología , Ratones , Humanos , Imiquimod/farmacología , Piel/patología , Piel/metabolismo , Piel/inmunología , Interleucina-22 , Dermatitis/inmunología , Dermatitis/genética , Dermatitis/patología , Dermatitis/metabolismo , Ratones Endogámicos C57BL , Interleucinas/genética , Interleucinas/metabolismo , Linfocitos T CD4-Positivos/inmunología , Linfocitos T CD4-Positivos/metabolismo , Inflamación/genética , Inflamación/metabolismo , Inflamación/inmunología , Inflamación/patología
11.
Arch Dermatol Res ; 316(7): 348, 2024 Jun 07.
Artículo en Inglés | MEDLINE | ID: mdl-38849562

RESUMEN

This study investigates the mechanism through which paeoniflorin inhibits TSLP expression to regulate dendritic cell activation in corticosteroid-dependent dermatitis treatment. Utilizing databases like TCMSP, we identified paeoniflorin's components, targets, and constructed networks. Molecular docking and gene enrichment analysis helped pinpoint key targets and pathways affected by paeoniflorin. In vitro and in vivo models were used to study CD80, CD86, cytokines, T-cell activation, skin lesions, histopathological changes, TSLP, CD80, and CD86 expression. Our study revealed paeoniflorin's active constituent targeting IL-6 in corticosteroid-dependent dermatitis. In vitro experiments demonstrated reduced TSLP expression, CD80, CD86, and cytokine secretion post-paeoniflorin treatment. In vivo, paeoniflorin significantly decreased skin lesion severity, cytokine levels, TSLP, CD80, and CD86 expression. The study highlights paeoniflorin's efficacy in inhibiting TSLP expression and suppressing dendritic cell activation in corticosteroid-dependent dermatitis, suggesting its potential as a therapeutic intervention. Additionally, it offers insights into the complex molecular mechanisms underlying paeoniflorin's anti-inflammatory properties in treating corticosteroid-dependent dermatitis.


Asunto(s)
Citocinas , Células Dendríticas , Glucósidos , Monoterpenos , Células Dendríticas/efectos de los fármacos , Células Dendríticas/inmunología , Células Dendríticas/metabolismo , Glucósidos/farmacología , Glucósidos/uso terapéutico , Animales , Citocinas/metabolismo , Monoterpenos/farmacología , Monoterpenos/uso terapéutico , Humanos , Ratones , Dermatitis/tratamiento farmacológico , Dermatitis/inmunología , Dermatitis/metabolismo , Interleucina-6/metabolismo , Simulación del Acoplamiento Molecular , Piel/patología , Piel/efectos de los fármacos , Piel/inmunología , Piel/metabolismo , Antiinflamatorios/farmacología , Antiinflamatorios/uso terapéutico , Modelos Animales de Enfermedad , Antígeno B7-1/metabolismo , Antígeno B7-2/metabolismo , Masculino , Linfopoyetina del Estroma Tímico , Activación de Linfocitos/efectos de los fármacos
12.
Br J Community Nurs ; 29(Sup5): S34-S36, 2024 May 01.
Artículo en Inglés | MEDLINE | ID: mdl-38728164

RESUMEN

Incontinence-associated dermatitis, previously and sometimes still referred to as moisture lesions or moisture damage, is a commonly seen contact dermatitis that is a reactive response of the skin to chronic contact to urine and faecal matter. Understanding the etiology is fundamental to creating a skin care plan and successfully prevention. Systemic reviews and studies have shown that the continued variability in management results from a combination of knowledge base, observation, diagnosis, and product selection. This article aims to improve clinicians' understanding of incontinence-associated dermatitis and its management.


Asunto(s)
Incontinencia Fecal , Cuidados de la Piel , Incontinencia Urinaria , Humanos , Incontinencia Urinaria/complicaciones , Incontinencia Fecal/complicaciones , Cuidados de la Piel/enfermería , Dermatitis por Contacto/etiología , Femenino , Dermatitis/etiología , Dermatitis/enfermería
13.
Appl Environ Microbiol ; 90(6): e0010524, 2024 Jun 18.
Artículo en Inglés | MEDLINE | ID: mdl-38742897

RESUMEN

Pododermatitis, also known as treponeme-associated hoof disease (TAHD), presents a significant challenge to elk (Cervus canadensis) populations in the northwestern USA, with Treponema spp. consistently implicated in the lesion development. However, identifying species-specific Treponema strains from these lesions is hindered by its culture recalcitrance and limited genomic information. This study utilized shotgun sequencing, in silico genome reconstruction, and comparative genomics as a culture-independent approach to identify metagenome-assembled Treponema genomes (MATGs) from skin scraping samples collected from captive elk experimentally challenged with TAHD. The genomic analysis revealed 10 new MATGs, with 6 representing novel genomospecies associated with pododermatitis in elk and 4 corresponding to previously identified species-Treponema pedis and Treponema phagedenis. Importantly, genomic signatures of novel genomospecies identified in this study were consistently detected in biopsy samples of free-ranging elk diagnosed with TAHD, indicating a potential etiologic association. Comparative metabolic profiling of the MATGs against other Treponema genomes showed a distinct metabolic profile, suggesting potential host adaptation or geographic uniqueness of these newly identified genomospecies. The discovery of novel Treponema genomospecies enhances our understanding of the pathogenesis of pododermatitis and lays the foundation for the development of improved molecular surveillance tools to monitor and manage the disease in free-ranging elk.IMPORTANCETreponema spp. play an important role in the development of pododermatitis in free-ranging elk; however, the species-specific detection of Treponema from pododermatitis lesions is challenging due to culture recalcitrance and limited genomic information. The study utilized shotgun sequencing and in silico genome reconstruction to identify novel Treponema genomospecies from elk with pododermatitis. The discovery of the novel Treponema species opens new avenues to develop molecular diagnostic and epidemiologic tools for the surveillance of pododermatitis in elk. These findings significantly enhance our understanding of the genomic landscape of the Treponemataceae consortium while offering valuable insights into the etiology and pathogenesis of emerging pododermatitis in elk populations.


Asunto(s)
Ciervos , Genoma Bacteriano , Treponema , Infecciones por Treponema , Treponema/genética , Treponema/clasificación , Treponema/aislamiento & purificación , Animales , Ciervos/microbiología , Infecciones por Treponema/microbiología , Infecciones por Treponema/veterinaria , Enfermedades del Pie/microbiología , Enfermedades del Pie/veterinaria , Filogenia , Dermatitis/microbiología , Dermatitis/veterinaria
14.
Pharmacol Res ; 205: 107231, 2024 Jul.
Artículo en Inglés | MEDLINE | ID: mdl-38815878

RESUMEN

We previously demonstrated that mice carrying natural mtDNA variants of the FVB/NJ strain (m.7778 G>T in the mt-Atp8 gene in mitochondrial complex V), namely C57BL/6 J-mtFVB/NJ (B6-mtFVB), exhibited (i) partial protection from experimental skin inflammatory diseases in an anti-murine type VII collagen antibody-induced skin inflammation model and psoriasiform dermatitis model; (ii) significantly altered metabolites, including short-chain fatty acids, according to targeted metabolomics of liver, skin and lymph node samples; and (iii) a differential composition of the gut microbiota according to bacterial 16 S rRNA gene sequencing of stool samples compared to wild-type C57BL/6 J (B6) mice. To further dissect these disease-contributing factors, we induced an experimental antibody-induced skin inflammatory disease in gnotobiotic mice. We performed shotgun metagenomic sequencing of caecum contents and untargeted metabolomics of liver, CD4+ T cell, and caecum content samples from conventional B6-mtFVB and B6 mice. We identified D-glucosamine as a candidate mediator that ameliorated disease severity in experimental antibody-induced skin inflammation by modulating immune cell function in T cells, neutrophils and macrophages. Because mice carrying mtDNA variants of the FVB/NJ strain show differential disease susceptibility to a wide range of experimental diseases, including diet-induced atherosclerosis in low-density lipoprotein receptor knockout mice and collagen antibody-induced arthritis in DBA/1 J mice, this experimental approach is valuable for identifying novel therapeutic options for skin inflammatory conditions and other chronic inflammatory diseases to which mice carrying specific mtDNA variants show differential susceptibility.


Asunto(s)
ADN Mitocondrial , Ratones Endogámicos C57BL , Animales , ADN Mitocondrial/genética , Microbioma Gastrointestinal , Ratones , Piel/metabolismo , Piel/microbiología , Piel/patología , Dermatitis/inmunología , Dermatitis/microbiología , Dermatitis/genética , Dermatitis/tratamiento farmacológico , Dermatitis/metabolismo , Inflamación/genética , Inflamación/inmunología , Modelos Animales de Enfermedad , Masculino , Vida Libre de Gérmenes , Psoriasis/tratamiento farmacológico , Psoriasis/inmunología , Psoriasis/genética , Ciego/microbiología , Enfermedad Crónica , Femenino
15.
Int J Infect Dis ; 145: 107058, 2024 Aug.
Artículo en Inglés | MEDLINE | ID: mdl-38697604

RESUMEN

Infective dermatitis associated with human T-cell lymphotropic virus type-1 (HTLV-1) (IDH) is a severe form of chronically infected eczema occurring in early childhood, although very rarely cases have been reported in adults. Most of the cases are from Jamaica and Brazil and occur in individuals with low socioeconomic status. IDH is always associated with refractory Staphylococcus aureus or beta-hemolytic Streptococcus infection of the skin and nasal vestibules. Patients with IDH may develop other even more severe HTLV-1-associated diseases, such as HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) of early or late appearance and adult T-cell leukemia/lymphoma. In the context of the Brazilian experience, it has been observed that 54% of IDH patients exhibit the juvenile form of HAM/TSP while the estimated incidence of adult HAM/TSP is 3%. As there are no curative treatments for HTLV-1 infection (or vaccines) or most of its associated diseases, prevention of infection is fundamental, mainly by vertical transmission, as it is responsible for the development of IDH, infantojuvenile HAM/TSP, and ATL. Public measures to reduce this transmission must be implemented urgently. Furthermore, it is recommended, mainly in HTLV-1 endemic areas, to search for HTLV-1 infection in all patients with infected eczema, even in adults.


Asunto(s)
Infecciones por HTLV-I , Virus Linfotrópico T Tipo 1 Humano , Humanos , Infecciones por HTLV-I/complicaciones , Infecciones por HTLV-I/diagnóstico , Infecciones por HTLV-I/epidemiología , Virus Linfotrópico T Tipo 1 Humano/aislamiento & purificación , Brasil/epidemiología , Paraparesia Espástica Tropical/diagnóstico , Paraparesia Espástica Tropical/virología , Paraparesia Espástica Tropical/epidemiología , Adulto , Dermatitis/virología , Dermatitis/diagnóstico
18.
Front Immunol ; 15: 1398453, 2024.
Artículo en Inglés | MEDLINE | ID: mdl-38745660

RESUMEN

Idiopathic Inflammatory Myopathies are rare conditions with several heterogeneous disease subtypes. They can range from limited muscle or skin involvement to severe, systemic, life-threatening disease. Although the etiology is unknown, some evidence suggests a role for external agents, particularly drugs. Herein, we present a case of a 71-year-old woman with chronic myeloid leukemia who developed imatinib-induced dermatomyositis sine dermatitis. The presentation was predominantly muscular, characterized by proximal muscle weakness and myalgia of the lower limbs, with positive anti-Mi2a antibodies. Spontaneous recovery was observed after drug discontinuation, without the need for immunosuppressive therapy. This is the first confirmed description of an imatinib-induced dermatomyositis sine dermatitis. It reflects the importance of a high awareness from rheumatologists and hematologists to accurately anticipate and identify similar situations.


Asunto(s)
Dermatomiositis , Mesilato de Imatinib , Humanos , Femenino , Anciano , Dermatomiositis/inducido químicamente , Dermatomiositis/diagnóstico , Dermatomiositis/inmunología , Mesilato de Imatinib/efectos adversos , Mesilato de Imatinib/uso terapéutico , Antineoplásicos/efectos adversos , Antineoplásicos/uso terapéutico , Leucemia Mielógena Crónica BCR-ABL Positiva/tratamiento farmacológico , Dermatitis/etiología , Dermatitis/diagnóstico , Dermatitis/tratamiento farmacológico
19.
Front Immunol ; 15: 1369849, 2024.
Artículo en Inglés | MEDLINE | ID: mdl-38779681

RESUMEN

Background: Stomolophus meleagris envenomation causes severe cutaneous symptoms known as jellyfish dermatitis. The potential molecule mechanisms and treatment efficiency of dermatitis remain elusive because of the complicated venom components. The biological activity and molecular regulation mechanism of Troxerutin (TRX) was firstly examined as a potential treatment for jellyfish dermatitis. Methods: We examined the inhibit effects of the TRX on tentacle extract (TE) obtained from S. meleagris in vivo and in vitro using the mice paw swelling models and corresponding assays for Enzyme-Linked Immunosorbent Assay (ELISA) Analysis, cell counting kit-8 assay, flow cytometry, respectively. The mechanism of TRX on HaCaT cells probed the altered activity of relevant signaling pathways by RNA sequencing and verified by RT-qPCR, Western blot to further confirm protective effects of TRX against the inflammation and oxidative damage caused by TE. Results: TE significantly induced the mice paw skin toxicity and accumulation of inflammatory cytokines and reactive oxygen species in vivo and vitro. Moreover, a robust increase in the phosphorylation of mitogen-activated protein kinase (MAPKs) and nuclear factor-kappa B (NF-κB) signaling pathways was observed. While, the acute cutaneous inflammation and oxidative stress induced by TE were significantly ameliorated by TRX treatment. Notablly, TRX suppressed the phosphorylation of MAPK and NF-κB by initiating the nuclear factor erythroid 2-related factor 2 signaling pathway, which result in decreasing inflammatory cytokine release. Conclusion: TRX inhibits the major signaling pathway responsible for inducing inflammatory and oxidative damage of jellyfish dermatitis, offering a novel therapy in clinical applications.


Asunto(s)
Dermatitis , Hidroxietilrutósido , Factor 2 Relacionado con NF-E2 , Estrés Oxidativo , Escifozoos , Transducción de Señal , Animales , Estrés Oxidativo/efectos de los fármacos , Ratones , Factor 2 Relacionado con NF-E2/metabolismo , Transducción de Señal/efectos de los fármacos , Dermatitis/tratamiento farmacológico , Dermatitis/metabolismo , Dermatitis/etiología , Humanos , Hidroxietilrutósido/análogos & derivados , Hidroxietilrutósido/farmacología , Hidroxietilrutósido/uso terapéutico , Venenos de Cnidarios/farmacología , Hemo-Oxigenasa 1/metabolismo , Modelos Animales de Enfermedad , Inflamación/tratamiento farmacológico , Inflamación/metabolismo , Masculino , Citocinas/metabolismo , Antiinflamatorios/farmacología , Antiinflamatorios/uso terapéutico , Células HaCaT , Especies Reactivas de Oxígeno/metabolismo , Proteínas de la Membrana
20.
Br J Community Nurs ; 29(6): 294-295, 2024 Jun 02.
Artículo en Inglés | MEDLINE | ID: mdl-38814833

RESUMEN

Incontinence-associated dermatitis (IAD) is often treated a hygienic challenge, rather than a serious condition with potentially life-threatening consequences. More appropriate education on the management strategies specific to IAD is required, in order for personalised and effective care that reflects the critical nature of this condition to be provided. Francesca Ramadan provides an overview of the key elements of best practice in IAD management and treatment.


Asunto(s)
Dermatitis , Incontinencia Fecal , Incontinencia Urinaria , Humanos , Incontinencia Urinaria/complicaciones , Incontinencia Fecal/complicaciones , Incontinencia Fecal/enfermería , Dermatitis/etiología , Dermatitis/enfermería , Cuidados de la Piel/enfermería , Enfermería en Salud Comunitaria , Femenino
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