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1.
Medicine (Baltimore) ; 99(27): e20989, 2020 Jul 02.
Artículo en Inglés | MEDLINE | ID: mdl-32629715

RESUMEN

BACKGROUND: Many genetic diseases are known to have distinctive facial phenotypes, which are highly informative to provide an opportunity for automated detection. However, the diagnostic performance of artificial intelligence to identify genetic diseases with facial phenotypes requires further investigation. The objectives of this systematic review and meta-analysis are to evaluate the diagnostic accuracy of artificial intelligence to identify the genetic diseases with face phenotypes and then find the best algorithm. METHODS: The systematic review will be conducted in accordance with the "Preferred Reporting Items for Systematic Reviews and Meta-Analyses Protocols" guidelines. The following electronic databases will be searched: PubMed, Web of Science, IEEE, Ovid, Cochrane Library, EMBASE and China National Knowledge Infrastructure. Two reviewers will screen and select the titles and abstracts of the studies retrieved independently during the database searches and perform full-text reviews and extract available data. The main outcome measures include diagnostic accuracy, as defined by accuracy, recall, specificity, and precision. The descriptive forest plot and summary receiver operating characteristic curves will be used to represent the performance of diagnostic tests. Subgroup analysis will be performed for different algorithms aided diagnosis tests. The quality of study characteristics and methodology will be assessed using the Quality Assessment of Diagnostic Accuracy Studies 2 tool. Data will be synthesized by RevMan 5.3 and Meta-disc 1.4 software. RESULTS: The findings of this systematic review and meta-analysis will be disseminated in a relevant peer-reviewed journal and academic presentations. CONCLUSION: To our knowledge, there have not been any systematic review or meta-analysis relating to diagnosis performance of artificial intelligence in identifying the genetic diseases with face phenotypes. The findings would provide evidence to formulate a comprehensive understanding of applications using artificial intelligence in identifying the genetic diseases with face phenotypes and add considerable value in the future of precision medicine. OSF REGISTRATION: DOI 10.17605/OSF.IO/P9KUH.


Asunto(s)
Cara/anomalías , Enfermedades Genéticas Congénitas/diagnóstico , Aprendizaje Profundo , Humanos , Desarrollo Maxilofacial/genética , Metaanálisis como Asunto , Fenotipo , Revisiones Sistemáticas como Asunto
2.
Cient. dent. (Ed. impr.) ; 17(1): 57-63, ene.-abr. 2020. tab
Artículo en Español | IBECS | ID: ibc-189750

RESUMEN

El objetivo de este trabajo es realizar una revisión bibliográfica para evaluar la posible relación entre los patrones de crecimiento facial con la maduración dental y esquelética en pacientes en crecimiento. La maduración dental y esquelética son dos indicadores que nos permiten es-tablecer en qué momento del desarrollo se encuentra el paciente en crecimiento. Actualmente, para la valoración de la maduración esquelética se emplea la visualización de las vértebras cervicales en la radiografía lateral de cráneo, ya que es un método que permite disminuir la exposición radiológica del paciente que se encuentra en estudio ortodóncico, en comparación con la radiografía de muñe-ca, la cual suponía la realización de una radiografía adicional. Para el análisis de la maduración dental, la radiografía panorámica es la más empleada mediante la visualización del desarrollo de los siete dientes mandibulares izquierdos. Los pacientes que se encuentran en edad infantil presentan diversos patrones de crecimiento facial, entre los que podemos encontrar, braquifacial, mesofacial y dolicofacial. Para poder establecer el patrón de crecimiento que presenta el paciente existen diversos métodos que, a través de mediciones cefalométricas, nos clasifican al paciente en uno de los tres grupos. Existen diversos trabajos que estudian la posible relación entre los patrones de crecimiento facial y la maduración dental y esquelética. Según la literatura revisada podemos concluir que los pacientes que presentan un patrón de crecimiento vertical muestran una maduración dental y esquelética más avanzada en comparación con los pacientes que presentan un patrón de crecimiento horizontal


The objective of this paper is to present a bibliographical review to evaluate the possible relationship between facial growth patterns and dental and skeletal maturation in growing patients.Dental and skeletal maturation are two indicators that allow us to establish at what point the patient is in his growth. Currently, for the evaluation of skeletal maturation, the visualisation of the cervical vertebrae in the lateral x-ray of the skull is used, since this is a method that diminishes the radiological exposure of the patient undergoing an orthodontic study, in comparison with the x-ray of the wrist, which means taking an additional x-ray.For the analysis of dental maturation, the panoramic x-ray is the most used through visualisation of the development of the seven left jaw teeth. Children in young ages present different facial growth patterns, among which we can find brachyfacial, mesofacial and dolichofacial. In order to establish the growth pattern the patient presents, there are different methods that, through cephalometric measurements, classify the patient in one of the three groups. Different papers study the possible relationship between facial growth patterns and dental and skeletal maturation. According to the reviewed literature, we can conclude that the patients who present a vertical growth pattern show more advanced dental and skeletal maturation in comparison with the patients who present a horizontal growth pattern


Asunto(s)
Humanos , Masculino , Femenino , Niño , Arco Dental/crecimiento & desarrollo , Desarrollo Maxilofacial/fisiología , Maxilar/crecimiento & desarrollo , Huesos Faciales/crecimiento & desarrollo , Cráneo/diagnóstico por imagen , Estudios Retrospectivos , Estudios Transversales , Estudios Longitudinales , Radiografía Panorámica , Cefalometría/métodos
3.
Am J Orthod Dentofacial Orthop ; 157(3): 365-376, 2020 Mar.
Artículo en Inglés | MEDLINE | ID: mdl-32115115

RESUMEN

INTRODUCTION: Currently, a standard of reference for longitudinal facial growth parameters for South American mestizos is lacking. Therefore, in this study, we describe an 18-year follow-up of craniofacial growth from 6 to 24 years of age in a Colombian mestizo population, and an analysis of facial growth beyond 18 years of age. METHODS: This 18-year follow-up longitudinal study was conducted in Medellín, Colombia. The study sample consisted of 49 mestizo subjects with normal facial features and no history of orthodontic treatment. Measurements of cranial base length, maxillary and mandibular length, posterior and anterior facial height, lower anterior facial height, and mandibular plane angle were documented at an X-ray magnification of 10%. Data were subjected to linear mixed model analysis. RESULTS: Changes in cephalometric measurements were detected during the 18-year follow-up and were significantly affected by age and sex. Pubertal growth spurts were between 12 and 14 years for females, and between 14 and 16 years of age for males. Mandibular plane angle decreased in both females and males during the 18-year follow-up. CONCLUSIONS: Age and sex significantly affect craniofacial growth in mestizos in Columbia. Beyond 18 years of age, craniofacial growth is important. Our data do not support sexual dimorphism in mandibular rotation in young adults.


Asunto(s)
Cara , Mandíbula , Desarrollo Maxilofacial , Adolescente , Cefalometría , Niño , Colombia , Femenino , Estudios de Seguimiento , Humanos , Estudios Longitudinales , Masculino , Adulto Joven
4.
Eur J Orthod ; 42(1): 24-29, 2020 Jan 27.
Artículo en Inglés | MEDLINE | ID: mdl-31586198

RESUMEN

OBJECTIVES: To assess differences in craniofacial growth at 8 years of age according to the different protocols for primary cleft surgery in the Scandcleft project. DESIGN AND SETTING: Prospective, randomized, controlled clinical trial (RCT) involving 10 centres, including non-syndromic Caucasians with unilateral cleft lip and palate (UCLP). In Trial 1, a common surgical method (1a) with soft palate closure at 3-4 months of age and hard palate closure at 12 months of age was tested against similar surgery but with hard palate repair at 36 months (delayed hard palate closure) (1b). In Trial 2, the common method (2a) was tested against simultaneous closure of both hard and soft palate at 1 year (2c). In Trial 3, the common method (3a) was tested against hard palate closure together with lip closure at 3 months of age and soft palate closure at 1 year of age (3d). Participants were randomly allocated by use of a dice. Operator blinding was not possible but all raters of all outcomes were blinded. SUBJECTS AND METHODS: The total number of participating patients at 8 years of age was 429. Lateral cephalograms (n = 408) were analysed. The cephalometric angles SNA and ANB were chosen for assessing maxillary growth for this part of the presentation. RESULTS: Within each trial (Trial 1a/1b, Trial 2a/2c, and Trial 3a/3d), there was no difference in cephalometric values between the common and the local arm. There were no statistically significant differences in the SNA and ANB angles between the common arm in Trial 1a (mean SNA 77.8, mean ANB 2.6) and Trial 2a (mean SNA 79.8, mean ANB 3.6) and no difference between Trial 1a and Trial 3a, but a statistical difference could be seen between Trial 2a and Trial 3a (mean SNA 76.9, mean ANB 1.7). However, the confidence interval was rather large. Intra- and inter-rater reliability were within acceptable range. CONCLUSIONS: The timing and the surgical method is not of major importance as far as growth outcomes (SNA and ANB) in UCLP are concerned. REGISTRATION: ISRCTN29932826. PROTOCOL: The protocol was not published before trial commencement.


Asunto(s)
Labio Leporino , Fisura del Paladar , Maxilar , Desarrollo Maxilofacial , Niño , Labio Leporino/cirugía , Fisura del Paladar/cirugía , Estudios de Seguimiento , Humanos , Maxilar/crecimiento & desarrollo , Maxilar/cirugía , Estudios Prospectivos , Ensayos Clínicos Controlados Aleatorios como Asunto , Reproducibilidad de los Resultados , Factores de Tiempo
5.
J Craniofac Surg ; 31(1): 186-188, 2020.
Artículo en Inglés | MEDLINE | ID: mdl-31261318

RESUMEN

Orthopedic treatment to improve deficient maxillary growth of cleft lip and palate patients is an important part of treatment. The success of this treatment is strongly dependent on the time of initiation of therapy. There has been a large controversy in the available literature regarding the skeletal age of these patients. The aim of the present study was to compare the skeletal age of cleft lip and palate patients with normal individuals.37 unilateral and 14 bilateral cleft lip and palate patients and 47 healthy individuals participated in this cross-sectional study. The patients were classified into 8 to 10 and 11 to 14-year-old individuals. Cervical vertebral maturational stage of participants was evaluated in the lateral cephalometry. The skeletal age of cleft lip and palate patients was compared with normal controls. Chi-square was used for statistical analysis. There was not a significant difference in the skeletal developmental stage of unilateral and bilateral cleft compared to their normal peers according to their age and sex. Also, significant difference in skeletal maturational stage of cleft lip and palate patients was not found between boys and girls (P = 0.8). Similarly, no significant difference was found in the skeletal age of the 3 studied groups without considering the age and sex of participants (P = 0.5). Regarding the similar skeletal maturational stage of cleft lip and palate patients with normal controls in our study, their maxillofacial orthopedic treatment can be initiated at similar time to normal peers.


Asunto(s)
Labio Leporino , Fisura del Paladar , Adolescente , Cefalometría , Vértebras Cervicales/crecimiento & desarrollo , Niño , Labio Leporino/cirugía , Fisura del Paladar/cirugía , Estudios Transversales , Femenino , Humanos , Masculino , Maxilar/crecimiento & desarrollo , Desarrollo Maxilofacial
6.
Orthod Craniofac Res ; 23(1): 50-58, 2020 Feb.
Artículo en Inglés | MEDLINE | ID: mdl-31465622

RESUMEN

OBJECTIVE: To identify trajectories of ontogenetic change in the mandibular plane angle (MPA) and to describe the influence of sex and other factors on MPA during growth. SETTING/SAMPLE: The data consisted of 7026 MPA measurements from lateral cephalographs representing longitudinal series from ages 6 to 21 for 728 individuals from the Craniofacial Growth Consortium Study (CGCS). MATERIALS AND METHODS: Facial type was determined from MPA for each assessment, with the assessment closest to age 18 representing the adult facial type. The sample includes 366 males and 362 females, each with between 2 and 15 cephalographs. The mean number of cephalographs per individual is 10. Variation in childhood MPA (earliest assessment between 6 and 9 years of age) and adult MPA (closest assessment to age 18 between 15 and 21 years of age), and change in MPA from childhood to adulthood were compared by sex and adult facial type using ANOVA and post hoc t tests. RESULTS: Mandibular plane angle decreased from childhood to adulthood in 92% of males and 81% of females, yet increased in 36% of males and 50% of females with the hyper-divergent adult facial type. Childhood MPA and overall change in MPA were significantly different by adult facial type. CONCLUSIONS: Adult facial type is associated with differences in childhood MPA and change in MPA during growth. There are multiple ontogenetic pathways by which an individual can achieve a normo-divergent adult facial type, and an individual's childhood MPA does not necessarily correspond to his or her adult facial type.


Asunto(s)
Cara , Mandíbula , Adolescente , Adulto , Cefalometría , Niño , Femenino , Humanos , Masculino , Desarrollo Maxilofacial , Adulto Joven
7.
Eur J Orthod ; 42(1): 36-43, 2020 Jan 27.
Artículo en Inglés | MEDLINE | ID: mdl-31722371

RESUMEN

OBJECTIVE: To evaluate the result of a novel palatoplasty (minimal incision technique) for closure of an isolated cleft palate (ICP) at 10 and 16 years of age, concerning facial growth, compared to a normal population. SUBJECTS: Treated group: 55 non-syndromic Caucasian children born with an ICP between 1987 and 2001. The children were treated surgically with a one-stage palatoplasty at a mean age of 13 months. Control group: 110 Caucasian children with normal occlusion with no history of clefts or orthodontic intervention. METHOD: The treated children (25 boys, 30 girls) were matched (gender and age) with the children in the control group. A retrospective evaluation at 10 (mean 10.5) and 16 (mean 16.0) years of age was performed by analysis of lateral cephalograms. Fifteen variables were evaluated. Ninety-nine per cent confidence intervals were calculated. Two-way factorial ANOVA and mixed-model analysis were performed. RESULTS: Treated patients compared to the control group showed: at 10 years of age, smaller mandible (P = 0.001) and reduced posterior upper and total face heights (P ≤ 0.001); at 10 and 16 years of age, a retrognathic (P ≤ 0.001), smaller (P ≤ 0.006) and with an increased posterior inclination of the maxilla (P < 0.001), as well as a retrognathic mandible (P ≤ 0.006). CONCLUSION: The craniofacial morphology at 10 and 16 years of age in patients born with an ICP and treated with the minimal incision technique differs compared to the morphology of a normal control group born without a cleft. Retrognathic maxillas and a smaller and posteriorly inclined maxilla were found in the treated group.


Asunto(s)
Labio Leporino , Fisura del Paladar , Desarrollo Maxilofacial , Cirugía Plástica , Adolescente , Cefalometría , Niño , Labio Leporino/cirugía , Fisura del Paladar/cirugía , Cara , Femenino , Estudios de Seguimiento , Humanos , Lactante , Masculino , Mandíbula , Maxilar , Estudios Retrospectivos , Cirugía Plástica/métodos
8.
Oral Maxillofac Surg Clin North Am ; 32(1): 117-134, 2020 Feb.
Artículo en Inglés | MEDLINE | ID: mdl-31699581

RESUMEN

Temporomandibular joint (TMJ) arthritis impacts mandibular growth and development. This can result in skeletal deformity, such as facial asymmetry and/or malocclusion asymmetry. This article reviews the unique properties of TMJ and dentofacial growth and development in the setting of juvenile idiopathic arthritis (JIA). Specific orthopedic/orthodontic and surgical management of children with JIA and TMJ arthritis is discussed. The importance of interdisciplinary collaboration is highlighted.


Asunto(s)
Artritis Juvenil/complicaciones , Deformidades Dentofaciales , Maloclusión , Procedimientos Quirúrgicos Ortognáticos/métodos , Trastornos de la Articulación Temporomandibular/complicaciones , Articulación Temporomandibular/patología , Niño , Humanos , Desarrollo Maxilofacial
9.
Elife ; 82019 11 26.
Artículo en Inglés | MEDLINE | ID: mdl-31763980

RESUMEN

The human face represents a combined set of highly heritable phenotypes, but knowledge on its genetic architecture remains limited, despite the relevance for various fields. A series of genome-wide association studies on 78 facial shape phenotypes quantified from 3-dimensional facial images of 10,115 Europeans identified 24 genetic loci reaching study-wide suggestive association (p < 5 × 10-8), among which 17 were previously unreported. A follow-up multi-ethnic study in additional 7917 individuals confirmed 10 loci including six unreported ones (padjusted < 2.1 × 10-3). A global map of derived polygenic face scores assembled facial features in major continental groups consistent with anthropological knowledge. Analyses of epigenomic datasets from cranial neural crest cells revealed abundant cis-regulatory activities at the face-associated genetic loci. Luciferase reporter assays in neural crest progenitor cells highlighted enhancer activities of several face-associated DNA variants. These results substantially advance our understanding of the genetic basis underlying human facial variation and provide candidates for future in-vivo functional studies.


Asunto(s)
Cara/anatomía & histología , Sitios Genéticos/genética , Desarrollo Maxilofacial/genética , Fenotipo , Adolescente , Adulto , Puntos Anatómicos de Referencia , Tipificación del Cuerpo/genética , Niño , Preescolar , Femenino , Regulación del Desarrollo de la Expresión Génica/genética , Ontología de Genes , Variación Genética , Estudio de Asociación del Genoma Completo , Genotipo , Humanos , Imagenología Tridimensional , Masculino , Persona de Mediana Edad , Herencia Multifactorial , Polimorfismo de Nucleótido Simple , Adulto Joven
10.
Artículo en Inglés | MEDLINE | ID: mdl-31726764

RESUMEN

Longitudinal epidemiological studies are considered the gold standard for understanding craniofacial morphologic development, but participant recruitment and retention can be challenging. This study describes strategies used to recruit and maintain a high level of participation in a longitudinal study involving annual three-dimensional (3D) craniofacial soft-tissue imaging from healthy Taiwanese Chinese elementary school students aged 6 to 12 years. The key aspects for project delineation, implementation, and the initial three-year practical experiment are portrayed in an integrated multistep workflow: ethics- and grant-related issues; contact, approval, and engagement from partners of the project (school stakeholders and parents); a didactic approach to recruit the students; research staff composition with task design; three station-based data collection days with two educative activities (oral hygiene and psychosocial interaction stations) and one 3D craniofacial imaging activity; and reinforcement tactics to sustain the longitudinal annual participation after the first enrollment. Randomly selected students and teachers answered an experience satisfaction questionnaire (five-point Likert scale ranging from one to five) designed to assist in understanding what they think about the data collection day. Measures of frequency (percentage) and central tendency (mean) were adopted for descriptive analysis. Six of seven contacted schools accepted participation in the project. All parents who attended the explanatory meetings agreed to join the project. A cohort of 676 students (336 girls) participated at baseline enrollment, with a follow-up rate of 96% in the second data collection. The average questionnaire-related scores were 4.2 ± 0.7 and 4.4 ± 0.6 for teachers and students, respectively. These 3D craniofacial norms will benefit multidisciplinary teams managing cleft-craniofacial deformities in the globally distributed ethnic Chinese population, particularly useful for phenotypic variation characterization, conducting quantitative morphologic comparisons, and therapeutic planning and outcome assessment. The described pathway model will assist other groups to establish their own age-, sex-, and ethnic-specific normative databases.


Asunto(s)
Desarrollo Maxilofacial , Flujo de Trabajo , Adolescente , Niño , Grupos Étnicos , Femenino , Humanos , Imagenología Tridimensional , Estudios Longitudinales , Masculino , Relaciones Profesional-Paciente , Investigadores , Instituciones Académicas , Estudiantes/estadística & datos numéricos , Encuestas y Cuestionarios , Taiwán
11.
Eur Arch Otorhinolaryngol ; 276(11): 3147-3151, 2019 Nov.
Artículo en Inglés | MEDLINE | ID: mdl-31486935

RESUMEN

INTRODUCTION: While most people believe the nasal septum to have intrinsic deviation and overgrowth in patients seeking rhinoplasty, an alternative concept is that a mal-oriented premaxilla causes extrinsic septal buckling and external extrusion of the septal cartilage. In this sense, the premaxillary bone plays a significant role in the pathogenesis of septal deviation. This study was performed to determine if non-traumatically acquired septal/nasal functional and aesthetic pathology or septal deviation may be related to the orientation of the premaxilla relative to the skullbase. METHODS: A retrospective, single-center study of patients in the general population who underwent maxillofacial CT scans and presented for the evaluation of nasal obstruction. CT scans were used to measure features of both pathologic and non-pathologic nasal septums. RESULTS: A total of 68 subjects were evaluated. When comparing patients with a premaxillary-skullbase angle of greater than 81° (the mean of the study group) to those of less than 81°, and a more obtuse nasolabial angle was observed (p = 0.0269). When comparing the extremes of premaxillary rotation, specifically, greater than 87° (mean 91.7°, SD 5.1) and less than 77° (mean 70.7°, SD 3.6), the differences were more pronounced with regard to caudal septal excess (p = 0.0451) and septal deviation in the axial plane (p = 0.0150). CONCLUSION: Septal developmental changes may involve an overly rotated or more vertically oriented premaxillary bone relative to the skull base. An understanding of the cause of septal deformity may provide insight into the design of improved treatments.


Asunto(s)
Maxilar/diagnóstico por imagen , Obstrucción Nasal , Tabique Nasal , Deformidades Adquiridas Nasales , Rinoplastia/métodos , Base del Cráneo/diagnóstico por imagen , Adulto , Femenino , Humanos , Masculino , Desarrollo Maxilofacial , Obstrucción Nasal/diagnóstico , Obstrucción Nasal/etiología , Tabique Nasal/diagnóstico por imagen , Tabique Nasal/patología , Deformidades Adquiridas Nasales/diagnóstico , Deformidades Adquiridas Nasales/etiología , Deformidades Adquiridas Nasales/cirugía , Estudios Retrospectivos , Tomografía Computarizada por Rayos X/métodos
12.
Rev. Asoc. Odontol. Argent ; 107(3): 95-102, jul.-sept. 2019. ilus, tab
Artículo en Español | LILACS | ID: biblio-1048102

RESUMEN

Objetivo: Describir la resolución de un caso un odontoma complejo de gran tamaño con utilización de osteosíntesis rígida. Caso clínico: Una paciente de 13 años de edad se presentó a la consulta por aumento de volumen en hemifacia izquierda, de 4 meses de evolución. Mediante biopsia incisional, se diagnosticó odontoma complejo. Se realizó tratamiento quirúrgico con utilización de osteosíntesis rígida. Se decidió retirar la placa de osteosíntesis a los 6 meses posoperatorios para evitar alterar el crecimiento y el desarrollo mandibular. Se indicó control posoperatorio durante 5 años. Conclusión: La utilización de osteosíntesis rígida fue adecuada para reforzar el defecto óseo mandibular producido durante el tratamiento quirúrgico de un odontoma complejo de gran tamaño (AU)


Aim: To describe the resolution of a case of a large complex odontoma with the use of rigid osteosynthesis. Clinical case: A 13-year-old patient presented with a swelling in left jaw of 4 months of evolution. Complex odontoma was diagnosed by incisional biopsy. Surgical treatment was performed with the use of rigid osteosynthesis. Removal of osteosynthesis plate was decided 6 months postoperatively to avoid alteration of mandibular growth and development. Postoperative control was indicated for 5 years. Conclusion: The use of rigid osteosynthesis was adequate to reinforce the mandibular bone defect produced during the surgical treatment of large complex odontoma (AU)


Asunto(s)
Humanos , Femenino , Adolescente , Anomalías Dentarias/clasificación , Odontoma , Fijación Interna de Fracturas , Fracturas Mandibulares/prevención & control , Argentina , Procedimientos Quirúrgicos Orales , Desarrollo Maxilofacial/fisiología
13.
Am J Orthod Dentofacial Orthop ; 156(2): 229-237.e4, 2019 Aug.
Artículo en Inglés | MEDLINE | ID: mdl-31375233

RESUMEN

INTRODUCTION: The growth of the craniofacial complex is important for establishing a balanced relationship among the teeth, jaws, and other facial structures. However, there is still a lack of information about craniofacial parameters that are affected by the rate of dental development. The aim of this study was to investigate the association between dental development and craniofacial morphology in school-age children. METHODS: This study was embedded in the Generation R Study, Rotterdam, The Netherlands. In 3,896 children aged 8 to 11 years, dental development was assessed from panoramic radiographs and craniofacial morphology was assessed by combining cephalometric parameters into 9 uncorrelated principal components, each representing a distinct skeletal or dental craniofacial pattern. The statistical analysis was performed using linear and nonlinear regression model. RESULTS: Dental development was positively associated with the bimaxillary growth (ß = 0.04; 95% CI 0.01 to 0.08). Children with above-average dental development had a tendency toward Class II jaw relationship (ß = -0.08; 95% CI -0.13 to -0.04). Regarding dental parameters, the proclination increased for incisors and lips with advanced dental development (ß = 0.15 [95% CI 0.10 to 0.19] and ß = 0.13 [95% CI 0.09 to 0.17], respectively), but the incisor proclination remained more pronounced in children that had above-average dental development. CONCLUSIONS: The findings of this large population-based study show that dental development is associated with specific dental and skeletal cephalometric characteristics in school-age children. Further longitudinal studies are necessary to confirm the observed effects over time.


Asunto(s)
Cara/anatomía & histología , Desarrollo Maxilofacial , Odontogénesis , Cefalometría , Niño , Huesos Faciales/anatomía & histología , Huesos Faciales/crecimiento & desarrollo , Femenino , Humanos , Incisivo , Labio/anatomía & histología , Estudios Longitudinales , Masculino , Maloclusión , Maxilar/anatomía & histología , Países Bajos , Radiografía Panorámica
14.
Dokl Biol Sci ; 486(1): 76-78, 2019 May.
Artículo en Inglés | MEDLINE | ID: mdl-31317449

RESUMEN

The transitory dermal infoldings are described for the first time in front and behind the upper jaw in the larvae and postlarvae of the American paddlefish, Polyodon spathula Walbaum, 1858. In sturgeons these infoldings are necessary for the jaw protraction. In the paddlefishes, they, probably recapitulate the ancestral state. At the same time, the presence of these folds at the larval stages might indicate that the paddlefish larvae possess the protractive jaws. Further developmental studies of the jaw kinematics in Polyodon spathula are needed to test both hypotheses.


Asunto(s)
Peces/anatomía & histología , Maxilares/anatomía & histología , Desarrollo Maxilofacial , Boca/anatomía & histología , Animales , Peces/crecimiento & desarrollo , Boca/crecimiento & desarrollo
16.
Plast Reconstr Surg ; 144(1): 180-186, 2019 07.
Artículo en Inglés | MEDLINE | ID: mdl-31246827

RESUMEN

BACKGROUND: The purpose of this study was to evaluate the effect of four different treatment protocols on maxillofacial growth in patients aged 7 to 8 years with unilateral complete cleft lip, palate, and alveolus. METHODS: Sixty-one patients with nonsyndromic unilateral complete cleft lip, palate, and alveolus were entered into this study and grouped as follows: group 1 patients had a repaired lip and an unrepaired palate; group 2 patients underwent one-stage palatoplasty; group 3 patients underwent two-stage palatoplasty; and group 4 patients underwent lip adhesion and two-stage palatoplasty. The control group was composed of 16 patients with unilateral incomplete cleft lip. The Kolmogorov-Smirnov test was used to test the nature of data distribution. The Bonferroni test and the Kruskal-Wallis H test were used for multiple comparisons. RESULTS: Group 5 showed a more protruding maxilla (basion-nasion-A point, basion-nasion-anterior nasal spine, sella-nasion-anterior nasal spine; p < 0.05), longer maxillary sagittal length (anterior nasal spine-posterior maxillary point; p < 0.05) and maxillary basal sagittal length (A point-posterior maxillary point; p < 0.05), and a better jaw relationship (A point-nasion-B point angle; p < 0.05) than groups 2, 3, and 4. Group 2 had higher anterior facial height (anterior nasal spine-nasion, anterior nasal spine-menton, nasion-menton; p < 0.05) and posterior facial height (registration point-posterior maxillary point; p < 0.05) than groups 3 and 4. Groups 2 and 3 had better maxillary position (sella-pterygomaxillary fissure; p < 0.05) and deeper bony pharynx (basion-posterior maxillary point; p < 0.05) than group 4. CONCLUSIONS: In patients aged 7 to 8 years with unilateral complete cleft lip, palate, and alveolus, both one- and two-stage palatoplasty inhibited maxillary sagittal growth. Vomer flap repair with denuded bone inhibited maxillary vertical growth. Lip adhesion did adversely affect maxilla position. CLINICAL QUESTION/LEVEL OF EVIDENCE: Therapeutic, III.


Asunto(s)
Proceso Alveolar/anomalías , Labio Leporino/cirugía , Fisura del Paladar/cirugía , Desarrollo Maxilofacial/fisiología , Proceso Alveolar/cirugía , Estudios de Casos y Controles , Niño , Preescolar , Labio Leporino/fisiopatología , Fisura del Paladar/fisiopatología , Protocolos Clínicos , Femenino , Humanos , Lactante , Masculino , Maxilar/crecimiento & desarrollo
17.
Forensic Sci Int ; 301: e1-e7, 2019 Aug.
Artículo en Inglés | MEDLINE | ID: mdl-31176532

RESUMEN

Child pornography on the internet is one of the crimes with highest increasing incidence worldwide. In this specific type of crime, the victim's age has important legal implications. To overcome the lack of scientifically established protocols, European researchers explored and proposed a set of facial proportions obtained from images to estimate age. Within a validation scope, the present study aimed to test the applicability of morphological proportions from frontal photographs of the face to estimate age in a Brazilian population. Standardized frontal view photographs from 800 Brazilians (400 females and 400 males) homogeneously distributed in 4 age groups (6, 10, 14 and 18 years ± 30 days) were randomly selected from a Civilian Database of the Brazilian Federal Police. The selected images were analyzed with the aid of cephalometric landmarks. After landmarking the photographs, eighteen metric relations pre-established by Cattaneo et al. (C. Cattaneo, Z. Obertová, M. Ratnayake, L. Marasciuolo, J. Tutkuviene, P. Poppa, D. Gibelli, P. Gabriel, S. Ritz-Timme, Can facial proportions taken from images be of use for ageing in cases of suspected child pornography? A pilot study, Int. J. Leg. Med. 126 2012 139-144) were assessed and analyzed through parametric statistical tests and discriminant analysis. Two indexes had a moderate correlation with age, while ten had a weak correlation and six were not correlated with age. Eleven indexes were statistically different between sexes (p < 0.05). The discriminant analysis showed that 49.6% of the pooled sample was correctly classified into the respective age group. This percentage increased when each sex was analyzed separately: 50.2% for females and 53.5% for males. The set of facial proportions from frontal images proposed by Cattaneo et al. (2012) is related to facial development. As expected, the discriminant power of this approach did not reach optimal effectiveness in the Brazilian sample. In practice, this age estimation method must be adapted for more reliable application in Brazilians.


Asunto(s)
Envejecimiento/fisiología , Cara/anatomía & histología , Desarrollo Maxilofacial/fisiología , Fotograbar , Adolescente , Puntos Anatómicos de Referencia , Brasil , Cefalometría , Niño , Bienestar del Niño/legislación & jurisprudencia , Crimen , Análisis Discriminante , Literatura Erótica , Femenino , Antropología Forense , Humanos , Masculino
18.
Rev. ADM ; 76(3): 156-161, mayo-jun. 2019. ilus, tab
Artículo en Español | LILACS | ID: biblio-1022128

RESUMEN

Durante el crecimiento y desarrollo de la cabeza, ésta lo hace en diferentes direcciones y proporciones, habiendo un límite entre la armonía /desarmonía conocido como umbral. Se hace referencia a este concepto, la forma de escribirlo y leerlo por medio de un código que lo simboliza. Objetivo: Poner al alcance de la comunidad médica un código de lectura e identificación de fenotipos craneofaciales sindrómicos y no sindrómicos. Conclusiones: Se considera que este concepto de umbral craneofacial y su código de lectura pueden ser usados en la enseñanza e investigación de la armonía-desarmonía durante el crecimiento y desarrollo de la cabeza, resultando ser de gran utilidad en la comprensión rápida y sencilla de la lectura del fenotipo craneofacial (AU)


During the growth and development of the head, it does so in different directions and proportions, there being a limit between the harmony / disharmony known as threshold. Reference is made to this concept, the way of writing it and reading it by means of a code that symbolizes it. Objective: To put within reach of the medical community, a code of reading and identification of syndromic and non-syndromic craniofacial phenotypes. Conclusions: It is considered that this concept of a craniofacial threshold and its reading code can be used in the teaching and research of harmony / disharmony during the growth and development of the head, being very useful in the quick and easy comprehension of the reading of the craniofacial phenotype (AU)


Asunto(s)
Humanos , Fenotipo , Herencia Multifactorial , Desarrollo Maxilofacial , Prognatismo , Retrognatismo , Cefalometría , Anomalías Craneofaciales/clasificación , Códigos , Estudios de Asociación Genética , Cabeza/crecimiento & desarrollo , Maloclusión/clasificación
19.
Forensic Sci Int ; 299: 239.e1-239.e9, 2019 Jun.
Artículo en Inglés | MEDLINE | ID: mdl-31053243

RESUMEN

OBJECTIVES: The aim of the present study was to use Fourier analysis to quantify and study age-related changes in midsagittal facial profile. MATERIALS AND METHODS: Midsagittal facial profiles were extracted as lists of x and y coordinates from 125 pairs of 3D facial scans captured at an average of 10.5 years apart for adult Japanese males aged 23-52 years. These were categorized into three 10-year-long age groups. Files of x and y coordinates underwent Fourier analysis at 30 harmonic levels. Paired t-tests were used to determine statistical significance of differences across corresponding harmonic coefficients. Mean harmonic coefficients were used to construct mean pre and post ageing profiles for each age group for qualitative comparisons. RESULTS: Full detail of facial profile was described by the first 20 harmonics. With increasing age, there was a trend of longitudinal changes involving more midsagittal shape features with increased magnitudes. However, all changes were lower than 1 mm. CONCLUSIONS: Fourier analysis is a useful morphometric approach to quantify age-related midsagittal facial changes. The small variations in the study groups prompt for testing Fourier analysis on the elderly and on other parasagittal and transverse facial features.


Asunto(s)
Envejecimiento , Análisis de Fourier , Desarrollo Maxilofacial , Adulto , Grupo de Ascendencia Continental Asiática , Ciencias Forenses , Humanos , Imagenología Tridimensional , Japón , Estudios Longitudinales , Persona de Mediana Edad , Fotograbar , Reproducibilidad de los Resultados , Adulto Joven
20.
PLoS One ; 14(5): e0217267, 2019.
Artículo en Inglés | MEDLINE | ID: mdl-31107914

RESUMEN

Three-dimensional (3D) surface imaging systems are replacing direct anthropometry as the preferred method for capturing facial soft-tissues. Aims of this study were: (1) to develop normative average 3D faces of healthy infants aged 3, 6, 9, and 12 months and (2) to describe normative average 3D facial growth data in infants aged 3 to 12 months. Three-dimensional images of 50 healthy children were acquired at 3, 6, 9, and 12 months of age using the 3dMDcranial system. Four average faces with uniform meshes (3, 6, 9, and 12 months) were developed and registered based on the children's reference frames. Distance maps of growth of the total facial surface and of the nose, upper lip, chin, forehead and cheeks for the intervals 3 to 6 months, 6 to 9 months, and 9 to 12 months of age were calculated. Mean growth of the total facial surface was 3.9 mm (standard deviation [SD] 1.2 mm), 3.5 mm (SD 0.9 mm), and 1.6 mm (SD 0.7 mm) at 3 to 6 months, 6 to 9 months, and 9 to 12 months, respectively. Regarding the selected regions of the face, the mean growth of the nose and upper lip were the largest (3.7 mm and 3.6 mm, respectively) between 6 and 9 months of age. The mean growth of the forehead, cheeks and chin were the largest (5.4 mm, 3.2, and 4.7 mm, respectively) between 3 and 6 months of age. For all facial regions, growth clearly diminished from 9 to 12 months of age. Normative data on the growth of the full face, nose, upper lip, chin, forehead and cheeks are presented. Such data can be used in future studies to identify the effectiveness of treatment of orofacial deformities such as orofacial clefts during the first year of life.


Asunto(s)
Cefalometría/métodos , Cara/anatomía & histología , Imagenología Tridimensional/métodos , Factores de Edad , Cefalometría/estadística & datos numéricos , Femenino , Humanos , Imagenología Tridimensional/estadística & datos numéricos , Lactante , Recién Nacido , Masculino , Desarrollo Maxilofacial , Modelos Anatómicos , Países Bajos , Valores de Referencia
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