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1.
Biol Trace Elem Res ; 200(1): 76-83, 2022 Jan.
Artículo en Inglés | MEDLINE | ID: mdl-33655432

RESUMEN

We aimed to investigate the association between zinc (Zn) supplementation and serum levels of copeptin, high-sensitive C-reactive protein (hs-CRP), glycemic control, anthropometric parameters and renal function in Zn -deficient diabetic hemodialysis patients (DHPs). This randomized, double-blind, placebo-controlled trial (RCT) was conducted on 46 DHPs with Zn-deficiency. The Zn supplement group (n = 21) received a 220-mg/day Zn sulfate capsule (containing 50 mg Zn), and the control group (n = 25) received a placebo capsule (220 mg corn starch), for 8 weeks. Fasting, predialysis blood samples were taken at baseline and after 8 weeks to assess fasting blood glucose (FBG), serum insulin, copeptin, high-sensitive C-reactive protein (hs-CRP), blood urea nitrogen (BUN), creatinine (Cr) concentrations, and homoeostatic model assessment (HOMA-IR) and quantitative insulin-sensitivity check index (QUICKI). Compared to controls, serum copeptin (P < 0.001), hs-CRP (P < 0.001), BUN (P < 0.001), Cr (P < 0.001), Zn (P < 0.001), FBG (P < 0.001) levels, BMI (P < 0.001), and body weight (P < 0.001) were significantly affected following ZnSO4 supplementation for 8 weeks. In contrast, QUICKI (P = 0.57), HOMA-IR (P = 0.60), and serum insulin (P = 0.55) were not affected following Zn supplementation in comparison with patients receiving placebo. Zn sulfate supplementation appears to have favorable effects on serum copeptin and hs-CRP, FBG, and renal function in Zn-deficient DHPs. Iranian Registry of Clinical Trials Identifier: IRCT20190806044461N1.


Asunto(s)
Diabetes Mellitus , Resistencia a la Insulina , Glucemia , Proteína C-Reactiva , Suplementos Dietéticos , Método Doble Ciego , Glicopéptidos , Humanos , Insulina , Irán , Diálisis Renal , Zinc , Sulfato de Zinc
2.
J Med Virol ; 94(1): 99-109, 2022 01.
Artículo en Inglés | MEDLINE | ID: mdl-34570905

RESUMEN

A severe pandemic of Coronavirus Disease (COVID-19) has been sweeping the globe since 2019, and this time, it did not stop, with frequent mutations transforming into virulent strains, for instance, B.1.1.7, B.1.351, and B.1.427. In recent months, a fungal infection, mucormycosis has emerged with more fatal responses and significantly increased mortality rate. To measure the severity and potential alternative approaches against black fungus coinfection in COVID-19 patients, PubMed, Google Scholar, World Health Organization (WHO) newsletters, and other online resources, based on the cases reported and retrospective observational analysis were searched from the years 2015-2021. The studies reporting mucormycosis with Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) coinfection and/or demonstrating potential risk factors, such as a history of diabetes mellitus or suppressed immune system were included, and reports published in non-English language were excluded. More than 20 case reports and observational studies on black fungus coinfection in COVID-19 patients were eligible for inclusion. The results indicated that diabetes mellitus, hyperglycemic, and immunocompromised COVID-19 patients with mucormycosis were at a higher risk. We found that it was prudent to assess the potential risk factors and severity of invasive mycosis via standardized diagnostic and clinical settings. Large-scale studies need to be conducted to identify early biomarkers and optimization of diagnostic methods has to be established per population and geographical variation. This will not only help clinicians around the world to detect the coinfection in time but also will prepare them for future outbreaks of other potential pandemics.


Asunto(s)
COVID-19/epidemiología , Coinfección/epidemiología , Mucormicosis/epidemiología , Mucormicosis/mortalidad , SARS-CoV-2/aislamiento & purificación , Diabetes Mellitus/patología , Humanos , Hiperglucemia/patología , Huésped Inmunocomprometido/fisiología , Mucorales/crecimiento & desarrollo , Mucorales/aislamiento & purificación , Mucormicosis/patología , Estudios Retrospectivos , Factores de Riesgo
3.
J Colloid Interface Sci ; 606(Pt 1): 261-271, 2022 Jan 15.
Artículo en Inglés | MEDLINE | ID: mdl-34390993

RESUMEN

Morphological and structural characteristics of semiconductors have a significant impact on their gas sensing characteristics. Reasonable design and synthesis of heterojunctions with special structures can effectively improve sensor performance. Herein, a cobalt oxide (Co3O4) nanofibers/cadmium sulfide (CdS) nanospheres hybrid was synthesized by an electrospinning method combined with a hydrothermal method to detect acetone gas. By adjusting loading amount of CdS, the sensing performance of CdS/Co3O4 sensor for acetone at room temperature (25 °C) was greatly ameliorated. In particular, the response of CdS/Co3O4 to 50 ppm acetone gas increased by 25% under 520 nm green light, meanwhile, the response/recovery time was shortened to 5 s/4 s. This is attributed to the heterojunction formed between CdS and Co3O4 as well as the influence of light excitation on the carrier concentration of the surfaces. Meanwhile, the unique high-porosity fiber structure and the catalytic action of cobalt ions also play an essential role in improving the performance. Furthermore, practical diabetic breath was experimentally simulated and proved the potential of the sensor in the future application of disease-assisted diagnosis.


Asunto(s)
Diabetes Mellitus , Nanofibras , Nanosferas , Acetona , Biomarcadores , Compuestos de Cadmio , Humanos , Sulfuros
4.
Food Chem ; 370: 131376, 2022 Feb 15.
Artículo en Inglés | MEDLINE | ID: mdl-34662793

RESUMEN

Mangiferin (MGF), from Mangifera indica is well reported for its hypoglycemic activity and hypolipidemic activity. However, MGF suffers therapeutic limitation due to poor solubility causing disparaging bioavailability. Herein to address this problem, we have incorporated MGF in alginate grafted N-succinylated chitosan (NSC) nanomatrix. Characterization by molecular docking, FT-IR and 2D-NMR (COSY) has revealed that MGF could reinforce interaction with NSC. The OH and CH2OH groups of MGF may set interactions with pyranosic OH, CH2OH, NH2 (or NH-succinyl and COOH-succinyl) of NSC. The NSC-MGF nanoconjugate revealed a spherical particle geometry of 100 âˆ¼ 200 nm size. The encapsulated MGF showed 100% release in vitro. In vivo, NSC-MGF nanoconjugate revealed blood glucose lowering from 300 mg/dL to âˆ¼ 90 mg/dL as well as âˆ¼ 37% lowering of total plasma cholesterol. This is well comparative to the earlier reports which acknowledged only 1 âˆ¼ 36% lowering of plasma cholesterol with MGF. Furthermore, NSC-MGF lowered serum trigyceride to âˆ¼ 61%, while in earlier studies, only 10 âˆ¼ 40% serum triglycerides reduction was found with solitary MGF.


Asunto(s)
Aterosclerosis , Quitosano , Diabetes Mellitus , Hiperlipidemias , Nanopartículas , Alginatos , Animales , Hiperlipidemias/tratamiento farmacológico , Simulación del Acoplamiento Molecular , Nanoconjugados , Tamaño de la Partícula , Ratas , Espectroscopía Infrarroja por Transformada de Fourier , Xantonas
5.
Spectrochim Acta A Mol Biomol Spectrosc ; 266: 120432, 2022 Feb 05.
Artículo en Inglés | MEDLINE | ID: mdl-34607092

RESUMEN

Diabetes has become one of the three chronic non-communicable diseases threatening human health in the world, and the detection of glucose concentration is of great importance for the prevention and treatment of diabetes. The noninvasive detection of glucose in tears has attracted interest over the past several decades, however, time-consuming, expensive equipment, and specialist technicians make tear analysis still challenging. Here, flexible surface-enhanced Raman scattering (SERS) substrates composed of gold nanoparticles (AuNPs) and two-dimensional MXene Ti3C2TX nanosheets have been designed. The GMXeP (gold nanoparticles with MXene nanosheets loaded on paper) SERS substrates show good sensitivity, reproducibility, and stability, yielding an enhancement factor (EF) of 3.7 × 105 at the concentration of 10-9 M. The GMXeP SERS substrates are used to detect glucose of diabetic tears within a linear range of 1-50 µM, the lowest detection concentration is 0.39 µM and the significant correlation between tear glucose and blood glucose indicates that this method is suitable for sensitive and noninvasive detection of blood glucose.


Asunto(s)
Diabetes Mellitus , Nanopartículas del Metal , Glucosa , Oro , Humanos , Reproducibilidad de los Resultados , Espectrometría Raman
6.
Environ Pollut ; 292(Pt B): 118453, 2022 Jan 01.
Artículo en Inglés | MEDLINE | ID: mdl-34737025

RESUMEN

Whether propylene oxide (PO) exposure is associated with hyperglycemia were rarely explored. We aimed to determine the relationship between PO exposure and glucose metabolism, and potential role of oxidative stress. Among 3294 Chinese urban adults, urinary PO metabolite (N-Acetyl-S-(2-hydroxypropyl)-L-cysteine, 2HPMA), biomarkers of oxidative DNA damage (8-oxo-7,8-dihydro-20-deoxyguanosine, 8-OHdG) and lipid peroxidation (8-isoprostane, 8-iso-PGF2α) in urine were determined. The associations of 2HPMA with 8-OHdG, 8-iso-PGF2α, fasting plasma glucose (FPG), and risk of diabetes were explored. The roles of 8-OHdG and 8-iso-PGF2α on association of 2HPMA with FPG and risk of diabetes were detected. After adjusted for potential confounders, each 1-unit increase in log-transformed concentration of 2HPMA was associated with a 0.15-mmol/L increase in FPG level, and the adjusted OR (95% CI) of diabetes by the associations of log-transformed urinary 2HPMA concentrations was 1.47 (95% CI: 1.03-2.11). Combination effects of 2HPMA with 8-OHdG or 8-iso-PGF2α on risk of diabetes were detected, and elevated 8-iso-PGF2α significantly mediated 34.5% of the urinary 2HPMA-associated FPG elevation. PO exposure was positively associated with FPG levels and risk of diabetes. PO exposure combined with DNA oxidative damage or lipid peroxidation may increase the risk of diabetes, and lipid peroxidation may partially mediate the PO exposure-induced FPG elevation.


Asunto(s)
Diabetes Mellitus , Ayuno , Adulto , Biomarcadores/metabolismo , Glucemia , Daño del ADN , Dinoprost , Compuestos Epoxi , Humanos , Peroxidación de Lípido , Estrés Oxidativo
7.
Infectio ; 25(4): 284-288, oct.-dic. 2021. tab
Artículo en Español | LILACS, COLNAL | ID: biblio-1286723

RESUMEN

Resumen Objetivo: Determinar los factores de riesgo a la infección en cavidad residual post quistectomía hepática en los pacientes del hospital Ramiro Prialé Prialé - EsSalud -Huancayo. Materiales y Métodos: Se realizó una cohorte retrospectiva, entre enero del 2014 y enero del 2018. Se utilizó una ficha de recolección de datos. Se obtuvieron los riesgos relativos (RR) crudos y ajustados, con intervalos de confianza al 95%. Resultados: Participaron 83 pacientes. El 41,2% de las mujeres presentaron infección en la cavidad postquistectomía y la mediana de edad de los pacientes infecta dos fue de 33 años. Los antecedentes patológicos que se relacionaron con la infección fueron obesidad o sobrepeso (62,5%), neoplasia previa (100%) y enferme dad inmunológica previa (31%). La infección en cavidad residual postquistectomía estuvo relacionada a la presencia de obesidad o sobrepeso, diabetes mellitus, neoplasia previa , cirugía previa y al uso de antibióticos posteriores a la cirugía. Conclusiones: La obesidad o sobrepeso, diabetes mellitus, haber padecido alguna neoplasia o cirugía previa y el uso de antibióticos luego de la cirugía; son factores de riesgo para la infección en cavidad residual postquistectomía hepática en los pacientes del Hospital Nacional Ramiro Prialé Prialé EsSalud de Huancayo, Perú.


Abstract Objective: To determine the risk factors with the infection in the residual cavity after hepatic cystectomy in the patients of the Ramiro Prialé Prialé hospital - EsSalud -Huancayo. Materials and Methods: A retrospective cohort was conducted, between January 2014 and January 2018. A data collection sheet was used. Crude and adjusted relative risks (RR) were obtained, with 95% confidence intervals. Results: 83 patients participated. 41.2% of women infected in the post-cystectomy cavity and the median age of infected patients was 33 years. The pathological antecedents that were related to the infection were obesity or overweight (62.5%), previous neoplasia (100%) and previous immune disease (31%). Post-cystectomy residual cavity infection was affected by the presence of obesity or overweight (aRR: 1.56; 95% CI: 1.15-2.13; p value = 0.005), diabetes mellitus (aRR: 2.67; 95% CI : 2.09-3.41; p value <0.001), previous neoplasia (aRR: 2.49; 95% CI: 1.94-3.20; p value <0.001), previous surgery (aRR: 1.49; 95% CI: 1.36-1.64; p value <0.001) and the use of post-surgery antibiotics (aRR: 2.14; 95% CI: 1.30-3.51; p value = 0.003) Conclusions: Obesity or overweight, diabetes mellitus, having suffered some neoplasia or previous surgery and the use of antibiotics after surgery; they are factors associated with infection in the residual post-cystectomy liver cavity in patients of the Ramiro Prialé Prialé EsSalud National Hospital in Huancayo, Peru.


Asunto(s)
Humanos , Femenino , Adulto , Procedimientos Quirúrgicos Operativos/efectos adversos , Factores de Riesgo , Infecciones , Perú , Ranunculaceae , Diabetes Mellitus , Equinococosis Hepática , Hospitales , Enfermedades del Sistema Inmune , Neoplasias
8.
Recurso de Internet en Portugués | LIS - Localizador de Información en Salud | ID: lis-48538

RESUMEN

Anualmente, o Dia Mundial do Diabetes é celebrado em 14 de novembro, uma data escolhida pela Federação Internacional de Diabetes (IDF) e pela Organização Mundial de Saúde (OMS) para reforçar a conscientização a respeito da doença. E em 2021 há mais um motivo para comemorar: a descoberta da insulina, medicamento essencial para a vida de milhões de pessoas ao redor do mundo, completou 100 anos.


Asunto(s)
Diabetes Mellitus , Insulina , Enfermedad Crónica/prevención & control
9.
Saudi Med J ; 42(11): 1237-1242, 2021 Nov.
Artículo en Inglés | MEDLINE | ID: mdl-34732557

RESUMEN

Woodhouse-Sakati syndrome (WSS) is a rare genetic condition of autosomal recessive inheritance pattern. The disease is characterized by a group of disorders, including diabetes mellitus, alopecia, hypogonadism, intellectual disability, and progressive extrapyramidal signs. This syndrome is related to an inherited neurodegenerative disorder's heterogeneous group characterized by the accumulation of iron in the brain, caused by a mutation in the DCAF17 gene. This report discusses the case of 3 Saudi sisters having WWS. The 3 sisters aged 18, 22, and 25 years took birth to consanguineous parents (first-degree cousins). The sisters initially had normal developmental growth with deprived scholastic performance because of the intellectual difficulties. At puberty, the secondary sexual characteristics were not developed in the patients, and they faced primary amenorrhea. They were found to have features typical of WSS, but they also had gynecological anomalies, which are considered unusual findings in WSS patients.


Asunto(s)
Diabetes Mellitus , Hipogonadismo , Discapacidad Intelectual , Alopecia/genética , Arritmias Cardíacas , Enfermedades de los Ganglios Basales , Femenino , Humanos , Hipogonadismo/diagnóstico , Hipogonadismo/genética , Discapacidad Intelectual/genética , Proteínas Nucleares , Arabia Saudita , Complejos de Ubiquitina-Proteína Ligasa
10.
Rev Med Chil ; 149(7): 971-979, 2021 Jul.
Artículo en Español | MEDLINE | ID: mdl-34751298

RESUMEN

BACKGROUND: Timely eye fundus examinations are essential to prevent the consequences of retinopathy among patients with type 2 diabetes mellitus. AIM: To assess the coverage rate (CR) of eye fundus examination in the Chilean diabetic population, between 2011 and 2019. MATERIAL AND METHODS: Analysis of monthly statistical summaries of the Cardiovascular Health Program published online by the Chilean Ministry of Health. The number of patients aged 15 years or more with a diagnosis of Type 2 diabetes mellitus and the number of those who had an eye fundus examination within the same year, were obtained. Data was analyzed at a national and regional level. RESULTS: The national eye fundus examination CR was 19.1% in 2011. In 2016, the figures became significantly higher, reaching 32.5%. In 2019, the highest value of 36.5% was recoded although not significantly different from 2016. The highest average annual CR was observed in Ñuble Health Service (49.5%), and the lowest in Central Metropolitan Service (15%). The highest CR positive absolute and relative variation between 2011 and 2019 was observed in Viña del Mar Quillota Health Service (38.9 and 489% respectively), and the lowest negative variation was observed in Araucania Norte Health Service (-8.42 and -24.21% respectively). CONCLUSIONS: There is a low eye fundus examination CR in Chile, with important differences between regional health services.


Asunto(s)
Diabetes Mellitus Tipo 2 , Diabetes Mellitus , Retinopatía Diabética , Chile/epidemiología , Diabetes Mellitus Tipo 2/complicaciones , Diabetes Mellitus Tipo 2/epidemiología , Retinopatía Diabética/diagnóstico , Retinopatía Diabética/epidemiología , Humanos
11.
BMC Bioinformatics ; 22(Suppl 5): 84, 2021 Nov 08.
Artículo en Inglés | MEDLINE | ID: mdl-34749634

RESUMEN

BACKGROUND: Doctors can detect symptoms of diabetic retinopathy (DR) early by using retinal ophthalmoscopy, and they can improve diagnostic efficiency with the assistance of deep learning to select treatments and support personnel workflow. Conventionally, most deep learning methods for DR diagnosis categorize retinal ophthalmoscopy images into training and validation data sets according to the 80/20 rule, and they use the synthetic minority oversampling technique (SMOTE) in data processing (e.g., rotating, scaling, and translating training images) to increase the number of training samples. Oversampling training may lead to overfitting of the training model. Therefore, untrained or unverified images can yield erroneous predictions. Although the accuracy of prediction results is 90%-99%, this overfitting of training data may distort training module variables. RESULTS: This study uses a 2-stage training method to solve the overfitting problem. In the training phase, to build the model, the Learning module 1 used to identify the DR and no-DR. The Learning module 2 on SMOTE synthetic datasets to identify the mild-NPDR, moderate NPDR, severe NPDR and proliferative DR classification. These two modules also used early stopping and data dividing methods to reduce overfitting by oversampling. In the test phase, we use the DIARETDB0, DIARETDB1, eOphtha, MESSIDOR, and DRIVE datasets to evaluate the performance of the training network. The prediction accuracy achieved to 85.38%, 84.27%, 85.75%, 86.73%, and 92.5%. CONCLUSIONS: Based on the experiment, a general deep learning model for detecting DR was developed, and it could be used with all DR databases. We provided a simple method of addressing the imbalance of DR databases, and this method can be used with other medical images.


Asunto(s)
Aprendizaje Profundo , Diabetes Mellitus , Retinopatía Diabética , Bases de Datos Factuales , Retinopatía Diabética/diagnóstico , Humanos , Retina
12.
Middle East Afr J Ophthalmol ; 28(2): 81-86, 2021.
Artículo en Inglés | MEDLINE | ID: mdl-34759664

RESUMEN

PURPOSE: Diabetic retinopathy (DR) is one of the leading causes of vision loss globally, and early detection plays a significant role in the prognosis. Several studies have been done on the single field fundus photography and artificial intelligence (AI) in DR screening using standardized data sets in urban outpatient settings. This study was carried out to validate AI algorithm in the detection of DR severity using fundus photography in real-time rural setting. METHODS: This cross-sectional study was carried out among 138 patients who underwent routine ophthalmic examination, irrespective of their diabetic status. The participants were subjected to a single field color fundus photography using nonmydriatic fundus camera. The images acquired were processed by AI algorithm for image quality, presence and refer ability of DR. The results were graded by four ophthalmologists. Interobserver variability between the four observers was also calculated. RESULTS: Of the 138 patients, 26 patients (18.84%) had some stage of DR, represented by 47 images (17.03%) positive for signs of DR. All 26 patients were immoderate or severe stage. About 6.5% of the images were considered as not gradable due to poor optical quality. The average agreement between pairs of the four graders was 95.16% for referable DR (RDR). The AI showed 100% sensitivity in detecting DR while the specificity for RDR was 91.47%. CONCLUSION: AI has shown excellent sensitivity and specificity in RDR detection, at par with the performance of individual ophthalmologists and is an invaluable tool for DR screening.


Asunto(s)
Diabetes Mellitus , Retinopatía Diabética , Algoritmos , Inteligencia Artificial , Estudios Transversales , Retinopatía Diabética/diagnóstico , Humanos , Tamizaje Masivo , Fotograbar
13.
Rev Med Liege ; 76(11): 817-823, 2021 Nov.
Artículo en Francés | MEDLINE | ID: mdl-34738756

RESUMEN

INTRODUCTION: Elderly people with diabetes represent a large and growing part of the general practitioners patient database, but their state of frailty compared to the non-diabetic population is poorly understood. OBJECTIVE: To study the relationship between diabetes and frailty in people aged 65 and over in primary care. METHOD: Frailty syndrome was assessed by the Fried Scale and compared between populations of diabetic and non-diabetic patients; 268 patients were studied, including 129 diabetic patients. RESULTS: Frailty was found in 27.9 % of older diabetic patients. The observed mean Fried score was 1.76 in people with diabetes versus 1.39 in non-diabetics, with more frail diabetic subjects (p = 0.007). In this study, HbA1c levels showed no significant association to frailty. CONCLUSION: Larger studies in several general practice clinics should be performed on subjects over 65 years of age with or without diabetes.


Asunto(s)
Diabetes Mellitus , Fragilidad , Anciano , Diabetes Mellitus/epidemiología , Anciano Frágil , Fragilidad/epidemiología , Evaluación Geriátrica , Humanos , Pacientes Ambulatorios , Estudios Prospectivos
14.
Rev Med Suisse ; 17(757): 1883-1887, 2021 Nov 03.
Artículo en Francés | MEDLINE | ID: mdl-34738763

RESUMEN

Improving glycaemia level is helpful to the clinician in diabetes management. Elderly diabetics make up a group that is non-homogeneous and with a very varied health status, whose treatment must be adjusted to take into account comorbidities, degree of frailty and both functional and mental disability, in addition to their life expectancy and personal preferences. Thus, the target of treatment should be defined along three categories of patients: robust, vulnerable and dependent. This article reviews information from the literature high-lighting current recommendations for treatment, the clear inclination towards overtreatment of the elderly diabetic and the resulting noxious effects of occurring hypoglycemia, that are often not recognized by the patient and his doctor.


Asunto(s)
Diabetes Mellitus , Fragilidad , Hipoglucemia , Anciano , Diabetes Mellitus/epidemiología , Diabetes Mellitus/terapia , Anciano Frágil , Fragilidad/terapia , Evaluación Geriátrica , Estado de Salud , Humanos , Hipoglucemia/epidemiología
15.
Curr Diab Rep ; 21(10): 43, 2021 11 01.
Artículo en Inglés | MEDLINE | ID: mdl-34719742

RESUMEN

PURPOSE OF REVIEW: Diabetic retinopathy (DR), a common cause of vision loss, is projected to increase worldwide, and is associated with significant morbidity. The current standard-of-care treatments can preserve and significantly improve vision in many patients affected by DR. However, challenges such as heavy treatment burden and refractory disease remain. The purpose of this review is to highlight and discuss investigative agents in development for the treatment of DR. RECENT FINDINGS: There are several novel agents with unique mechanisms that may offer greater durability and efficacy compared to existing drugs. Some target new pathways, others leverage a slow-release delivery system, and some modify gene expression through a single-dose treatment. While unfavorable adverse events, such as intraocular inflammation, have been observed with longer-durability agents, many investigational products show excellent efficacy and safety profiles. The outcomes of ongoing and future trials may revolutionize the current treatment paradigm for DR.


Asunto(s)
Diabetes Mellitus , Retinopatía Diabética , Edema Macular , Inhibidores de la Angiogénesis/uso terapéutico , Retinopatía Diabética/tratamiento farmacológico , Humanos , Edema Macular/tratamiento farmacológico , Edema Macular/etiología
17.
Rev Saude Publica ; 55: 61, 2021.
Artículo en Inglés, Español | MEDLINE | ID: mdl-34730747

RESUMEN

OBJECTIVES: To analyze the behavior of mortality from diabetes mellitus (DM) for both sexes in Mexico from 1998 to 2018, and its impact on life expectancy (LE) from 60 to 85 years of age in the three-year periods 1998-2000 and 2016-2018, compared with other causes of death, as well as to determine the loss of years of life expectancy associated with DM in each three-year period. METHODS: The current study is observational and descriptive. Age-adjusted rates of mortality from DM were calculated for each sex from 1998 to 2018. Sex-specific life tables were constructed for 1998-2000 and 2016-2018, and both LE between 60 and 85 years, and years of life expectancy lost (YLELL) due to DM and selected causes between both ages were calculated. RESULTS: Between 1998 and 2018, the adjusted DM-resulting male mortality rate grew 55% in the population aged 60 and over, while the female mortality rate grew 20%. Between 1998-2000 and 2016-2018, male LE for 60-85 age group decreased 0.22 years, while female LE increased 0.24. In 2016-2018, DM was responsible for 1.30 YLEL among men of 60 to 85 years (19% of the total YLEL), and 1.24 YLEL for women (24% of the total), more than the other causes analyzed. CONCLUSIONS: The increase in mortality from DM has substantially contributed both to reduce LE of older adult men, and to slow the increase of LE among women aged 60 years and older so far this century. Thus, preventive policies should be implemented since early ages to reduce the high levels of overweight and obesity in the country and, therefore, the significant population ratio suffering from DM.


Asunto(s)
Diabetes Mellitus , Esperanza de Vida , Anciano , Brasil , Causas de Muerte , Diabetes Mellitus/epidemiología , Femenino , Humanos , Lactante , Masculino , México/epidemiología , Persona de Mediana Edad , Mortalidad , Sobrepeso
18.
Zhongguo Yi Xue Ke Xue Yuan Xue Bao ; 43(5): 796-800, 2021 Oct.
Artículo en Chino | MEDLINE | ID: mdl-34728042

RESUMEN

Diabetic retinopathy(DR)is the major microvascular disease in diabetic patients,and it is also one of the main blinding eye diseases in the current population.The typical pathological change of DR in the eyes is vascular endothelial growth factor(VEGF)-mediated neovascularization induced by retinal ischemic stimulation.Therefore,anti-VEGF drugs have gradually become one of the mainstream methods to treat DR and DR-induced diseases such as diabetic macular edema.Recent studies have proved that anti-VEGF drugs have certain effects on ocular blood vessels and blood flow in patients with DR,while the specific mechanism has not been fully elucidated.This article summarizes the research progress on the effects of intravitreal injection of anti-VEGF drugs on the ocular blood vessels and blood flow in patients with DR.


Asunto(s)
Diabetes Mellitus , Retinopatía Diabética , Edema Macular , Preparaciones Farmacéuticas , Inhibidores de la Angiogénesis/uso terapéutico , Retinopatía Diabética/tratamiento farmacológico , Humanos , Inyecciones Intravítreas , Edema Macular/tratamiento farmacológico , Factor A de Crecimiento Endotelial Vascular , Factores de Crecimiento Endotelial Vascular/uso terapéutico
19.
Artículo en Inglés | MEDLINE | ID: mdl-34770043

RESUMEN

Diabetes-related foot disease (DFD) is a major public health concern due to the higher risks of hospitalisation. However, estimates of the prevalence of DFD in the general population are not available in Australia. This study aims to estimate the prevalence of DFD and diabetes-related lower-extremity amputation (DLEA) among people aged 45 years and over in New South Wales (NSW), Australia. The NSW 45 and Up Study baseline survey data of 267,086 persons aged 45 years and over, linked with health services' administrative data from 2006 to 2012 were used in our study. Of these, 28,210 individuals had been diagnosed with diabetes, and our study identified 3035 individuals with DFD. The prevalence of DFD, diabetic foot ulcer (DFU), diabetic foot infection (DFI), diabetic gangrene (DG), and DLEA were 10.8% (95%CI: 10.3, 11.2), 5.4% (95% CI: 5.1, 5.8), 5.2% (95%CI: 4.9, 5.5), 0.4% (95%CI: 0.3, 0.5), and 0.9% (95%CI: 0.7, 1.0), respectively. DFD, DFU, DFI, DG, and DLEA were the most common among those who were older, born in Australia, from low-income households (

Asunto(s)
Diabetes Mellitus , Pie Diabético , Enfermedades del Pie , Australia , Diabetes Mellitus/epidemiología , Pie Diabético/epidemiología , Hospitalización , Humanos , Nueva Gales del Sur/epidemiología , Prevalencia , Encuestas y Cuestionarios
20.
Artículo en Inglés | MEDLINE | ID: mdl-34770132

RESUMEN

Morbidity and mortality due to noncommunicable diseases (NCDs) are growing exponentially across Tanzania. The limited availability of dedicated services and the disparity between rural and urban areas represent key factors for the increased burden of NCDs in the country. From March 2019, an integrated management system was started in the Iringa District Council. The system implements an integrated management of hypertension and diabetes between the hospital and the peripheral health centers and introduces the use of paper-based treatment cards. The aim of the study was to present the results of the first 6 months' roll-out of the system, which included 542 patients. Data showed that 46.1% of patients returned for the reassessment visit (±1 month), more than 98.4% of patients had blood pressure measured and were checked for complication, more than 88.6% of patients had blood sugar tested during follow-up visit, and blood pressure was at target in 42.8% of patients with hypertension and blood sugar in 37.3% of diabetic patients. Most patients who were lost to follow-up or did not reach the targets were those without medical insurance or living in remote peripheries. Our findings suggest that integrated management systems connecting primary health facilities and referral hospitals may be useful in care and follow-up of patients with hypertension and diabetes.


Asunto(s)
Diabetes Mellitus , Hipertensión , Enfermedades no Transmisibles , Presión Sanguínea , Diabetes Mellitus/epidemiología , Diabetes Mellitus/terapia , Humanos , Hipertensión/epidemiología , Hipertensión/terapia , Enfermedades no Transmisibles/epidemiología , Enfermedades no Transmisibles/terapia , Tanzanía/epidemiología
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