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1.
Zhongguo Yi Liao Qi Xie Za Zhi ; 45(2): 159-162, 2021 Apr 08.
Artículo en Chino | MEDLINE | ID: mdl-33825374

RESUMEN

Aiming at the low efficiency and low quality detection level of the manual infusion set, a gas detection system for infusion set based on STM32 single-chip microcomputer was designed. The detection system includes hardware system design and software system design. The hardware system is based on the STM32F103 single-chip microcomputer. It mainly designs the gas pressure sensor acquisition circuit and the multi-way solenoid valve control circuit. The software system uses a C ++ real-time operating system to ensure system monitoring's real-time performance and validity. Test data is transmitted to the upper computer and displayed via USB serial communication. The experiment proves that the infusion set gas detection system can perform gas detection on the infusion set. The system has the characteristics of stability and high accuracy. The relative error of the experimental measurement is within ±5%, and the detection efficiency is better than manual detection.


Asunto(s)
Microcomputadores , Programas Informáticos , Computadores , Diseño de Equipo
2.
Zhongguo Yi Liao Qi Xie Za Zhi ; 45(2): 228-230, 2021 Apr 08.
Artículo en Chino | MEDLINE | ID: mdl-33825388

RESUMEN

This study established a rapid ECG screening system through the application of wearable ECG equipment. The closed-loop and self-service process of ECG inspection, data collection, transmission and printing have been realized. The new rapid ECG screening system docking with HIS system in the hospital, forming a new intelligent mode of rapid ECG screening. This paper introduces the design of the intelligent mode of ECG rapid screening from the aspects of hardware, software, wearable ECG examination equipment, and briefly describes its implementation path and technical scheme. With the rapid ECG screening system, human power can be saved, the timeliness of ECG examination can be enhanced. The level of ECG diagnosis in the basic units can be improved through building a multiple medical centers which is rely on the cloud platform.


Asunto(s)
Electrocardiografía , Dispositivos Electrónicos Vestibles , Diseño de Equipo , Humanos , Investigación , Programas Informáticos
3.
Anticancer Res ; 41(4): 2123-2132, 2021 Apr.
Artículo en Inglés | MEDLINE | ID: mdl-33813423

RESUMEN

BACKGROUND/AIM: Surgical stress has been correlated with higher rate of postoperative complications. Breast implants' surfaces (textured or smooth) represent an immunological stimulus. Our prospective study (BIAL2.20) evaluated post-operative leukocytes response at baseline and postoperative day (POD) 1 and 2 after implant-based breast reconstruction. PATIENTS AND METHODS: Between January and July 2020, 41 patients underwent reconstruction with textured (n=23) or smooth (n=18) implants. A full blood count and lymphocyte subsets were collected before surgery, on POD1 and POD2. Data were evaluated as difference and relative difference from baseline by two-way analysis of variance test (2-way-ANOVA). Mann-Whitney U-test was performed at each POD, whenever between-group 2-way-ANOVA reached statistical significance. RESULTS: Within-group-analysis showed statistically significant total leukocytosis in both groups. Within-group-analysis of lymphocytes subsets demonstrated statistically significant lymphopenia in the textured group for T-lymphocytes, and T-helper cells. Between-group-analysis showed statistically significant lymphopenia in T-helper subsets in the textured group at POD1 and POD2, when compared with the smooth group. CONCLUSION: Textured implants demonstrated a statistically significant impairment of T-helper trend during POD1 and POD2 when compared to smooth implants by between-group 2-way-ANOVA.


Asunto(s)
Implantación de Mama , Implantes de Mama/efectos adversos , Linfopenia/etiología , Mamoplastia , Complicaciones Posoperatorias/inmunología , Linfocitos T Colaboradores-Inductores/patología , Adulto , Anciano , Implantación de Mama/efectos adversos , Implantación de Mama/instrumentación , Implantación de Mama/métodos , Neoplasias de la Mama/patología , Neoplasias de la Mama/cirugía , Diseño de Equipo/efectos adversos , Femenino , Humanos , Linfopenia/diagnóstico , Linfopenia/inmunología , Mamoplastia/efectos adversos , Mamoplastia/instrumentación , Mamoplastia/métodos , Mastectomía/métodos , Persona de Mediana Edad , Complicaciones Posoperatorias/diagnóstico , Complicaciones Posoperatorias/patología , Periodo Posoperatorio , Estudios Prospectivos , Factores de Tiempo
4.
Sensors (Basel) ; 21(5)2021 Feb 26.
Artículo en Inglés | MEDLINE | ID: mdl-33652644

RESUMEN

A textile patch antenna is an attractive package for wearable applications as it offers flexibility, less weight, easy integration into the garment and better comfort to the wearer. When it comes to wearability, above all, comfort comes ahead of the rest of the properties. The air permeability and the water vapor permeability of textiles are linked to the thermophysiological comfort of the wearer as they help to improve the breathability of textiles. This paper includes the construction of a breathable textile rectangular ring microstrip patch antenna with improved water vapor permeability. A selection of high air permeable conductive fabrics and 3-dimensional knitted spacer dielectric substrates was made to ensure better water vapor permeability of the breathable textile rectangular ring microstrip patch antenna. To further improve the water vapor permeability of the breathable textile rectangular ring microstrip patch antenna, a novel approach of inserting a large number of small-sized holes of 1 mm diameter in the conductive layers (the patch and the ground plane) of the antenna was adopted. Besides this, the insertion of a large number of small-sized holes improved the flexibility of the rectangular ring microstrip patch antenna. The result was a breathable perforated (with small-sized holes) textile rectangular ring microstrip patch antenna with the water vapor permeability as high as 5296.70 g/m2 per day, an air permeability as high as 510 mm/s, and with radiation gains being 4.2 dBi and 5.4 dBi in the E-plane and H-plane, respectively. The antenna was designed to resonate for the Industrial, Scientific and Medical band at a specific 2.45 GHz frequency.


Asunto(s)
Textiles , Dispositivos Electrónicos Vestibles , Tecnología Inalámbrica , Radiación Electromagnética , Diseño de Equipo
5.
Artículo en Inglés | MEDLINE | ID: mdl-33652982

RESUMEN

The COVID-19 pandemic has drawn attention to microbial transmission risk via aerosols in dental practice. Demonstration electric toothbrushes are used intra-orally for education. The aim of this investigation was to measure the size of droplets emitted by the brush head of two demonstration oscillating-rotating electric toothbrushes. Measurement of droplet production and size was recorded in vitro using three methods: (1) Malvern Spraytec (LASER particle size measurement device with detectable particle size of 0.1-2500 µm) and brushes mounted on a 3D-printed, two-shell form-fit fixture with a supply of tap water; (2) a DustTrak aerosol measurement device and toothpaste slurry, with brushing simulated in the oral cavity of a phantom head; (3) high-speed visualization in a simulated-use situation in the oral cavity of a phantom head, with individual evaluation of tap water, water with detergent, 70% ethanol, glycerin and toothpaste slurry. Both brushes showed the size of emitted droplets was consistently between 200 and 1200 µm, categorized as splatter (dental aerosols are <50 µm diameter). No significant incremental aerosol-sized matter was detected during toothbrush operation. The high-speed video visualization confirmed only splatter-sized droplets during operation. These findings indicate that oscillating-rotating toothbrushes do not produce aerosol-sized particles during simulated use.


Asunto(s)
Aerosoles/análisis , Equipo Dental , Cepillado Dental/instrumentación , Diseño de Equipo , Pastas de Dientes
6.
Nat Commun ; 12(1): 1478, 2021 03 05.
Artículo en Inglés | MEDLINE | ID: mdl-33674570

RESUMEN

The recently introduced minimal photon fluxes (MINFLUX) concept pushed the resolution of fluorescence microscopy to molecular dimensions. Initial demonstrations relied on custom made, specialized microscopes, raising the question of the method's general availability. Here, we show that MINFLUX implemented with a standard microscope stand can attain 1-3 nm resolution in three dimensions, rendering fluorescence microscopy with molecule-scale resolution widely applicable. Advances, such as synchronized electro-optical and galvanometric beam steering and a stabilization that locks the sample position to sub-nanometer precision with respect to the stand, ensure nanometer-precise and accurate real-time localization of individually activated fluorophores. In our MINFLUX imaging of cell- and neurobiological samples, ~800 detected photons suffice to attain a localization precision of 2.2 nm, whereas ~2500 photons yield precisions <1 nm (standard deviation). We further demonstrate 3D imaging with localization precision of ~2.4 nm in the focal plane and ~1.9 nm along the optic axis. Localizing with a precision of <20 nm within ~100 µs, we establish this spatio-temporal resolution in single fluorophore tracking and apply it to the diffusion of single labeled lipids in lipid-bilayer model membranes.


Asunto(s)
Imagenología Tridimensional/instrumentación , Imagenología Tridimensional/métodos , Microscopía Fluorescente/instrumentación , Microscopía Fluorescente/métodos , Difusión , Diseño de Equipo , Fluorescencia , Colorantes Fluorescentes , Procesamiento de Imagen Asistido por Computador , Fotones
7.
Undersea Hyperb Med ; 48(1): 81-88, 2021.
Artículo en Inglés | MEDLINE | ID: mdl-33648037

RESUMEN

The snorkel allows a surface swimmer to observe the underwater world through the face mask without being disturbed by inhaling. The effect of a snorkel on breathing resistance and cost is widely held to be substantial. This study aims to model these parameters and to measure indirectly the actual increases. Further, resistances of differing designs and dimensions were assessed and recommendations were made concerning use and choice. Maximal voluntary ventilation in 12 seconds (MVV12) was measured in 19 volunteers seated on dry land with and without a classic J-type snorkel (inner diameter 20.5 mm). The extra and total resistances and costs were calculated using the MVV12 data and using estimated airways resistance extrapolated from subject's demography and spirometric literature data. MVV12 measurements with snorkel showed a minute volume of 152 ±38 L∙min-1, 6.0 ±3.7% lower than without snorkel (p = 7.0x10-6). The theoretical MVV12, calculated from snorkel and airways resistances, decreased by 3.2%. Experimental total breathing resistance (457±83 Pa∙s∙L-1) was 6.5 ± 3.2% higher than without snorkel (p = 2.6x10-7), but the total mechanical breathing cost was unaffected by the snorkel (13.58 Watts with; 13.64 Watts without). Divers' estimations of resistance increase were exaggerated (8.8% at rest, 23% swimming). Classical J-type snorkels with an inner diameter ≥19.5 mm add 3-16% resistance . There is no risk of hypercapnia. Scuba divers are recommended to use their snorkel to breathe more comfortably on the surface. It is recommended the snorkel be made a mandatory safety accessory. The best multipurpose snorkel (19-21 mm) has no top appendages and no water release valve.


Asunto(s)
Resistencia de las Vías Respiratorias/fisiología , Buceo/fisiología , Respiración , Equipo Deportivo , Natación/fisiología , Algoritmos , Diseño de Equipo , Humanos , Hipercapnia/etiología , Mecánica Respiratoria/fisiología , Equipo Deportivo/efectos adversos
8.
PLoS One ; 16(3): e0247797, 2021.
Artículo en Inglés | MEDLINE | ID: mdl-33661960

RESUMEN

Since the initial identification of the novel coronavirus SARS-CoV-2 in December of 2019, researchers have raced to understand its pathogenesis and begun devising vaccine and treatment strategies. An accurate understanding of the body's temporal immune response against SARS-CoV-2 is paramount to successful vaccine development and disease progression monitoring. To provide insight into the antibody response against SARS-CoV-2, plasma samples from 181 PCR-confirmed COVID-19 patients collected at various timepoints post-symptom onset (PSO) were tested for the presence of anti-SARS-CoV-2 IgM and IgG antibodies via lateral flow. Additionally, 21 donors were tracked over time to elucidate patient-specific immune responses. We found sustained levels of anti-SARS-CoV-2 antibodies past 130 days PSO, with 99% positivity observed at 31-60 days PSO. By 61-90 days PSO, the percentage of IgM-/IgG+ results were nearly equal to that of IgM+/IgG+ results, demonstrating a shift in the immune response with a decrease in IgM antibody levels. Results from this study not only provide evidence that the antibody response to COVID-19 can persist for over 4 months, but also demonstrates the ability of Easy Check™ to monitor seroconversion and antibody response of patients. Easy Check was sufficiently sensitive to detect antibodies in patient samples as early as 1-4 days PSO with 86% positivity observed at 5-7 days PSO. Further studies are required to determine the longevity and efficacy of anti-SARS-CoV-2 antibodies, and whether they are protective against re-infection.


Asunto(s)
Anticuerpos Antivirales/sangre , Inmunoglobulina G/sangre , Inmunoglobulina M/sangre , /inmunología , Adolescente , Adulto , Anciano , Anciano de 80 o más Años , Anticuerpos Antivirales/inmunología , /instrumentación , Diseño de Equipo , Femenino , Humanos , Inmunoglobulina G/inmunología , Inmunoglobulina M/inmunología , Estudios Longitudinales , Masculino , Persona de Mediana Edad , Adulto Joven
9.
Sensors (Basel) ; 21(5)2021 Feb 24.
Artículo en Inglés | MEDLINE | ID: mdl-33668250

RESUMEN

Textile electrodes, also called textrodes, for biosignal monitoring as well as electrostimulation are central for the emerging research field of smart textiles. However, so far, only the general suitability of textrodes for those areas was investigated, while the influencing parameters on the contact impedance related to the electrode construction and external factors remain rather unknown. Therefore, in this work, six different knitted electrodes, applied both wet and dry, were compared regarding the influence of specific knitting construction parameters on the three-electrode contact impedance measured on a human forearm. Additionally, the influence of applying pressure was investigated in a two-electrode setup using a water-based agar dummy. Further, simulation of an equivalent circuit was used for quantitative evaluation. Indications were found that the preferred electrode construction to achieve the lowest contact impedance includes a square shaped electrode, knitted with a high yarn density and, in the case of dry electrodes, an uneven surface topography consisting of loops, while in wet condition a smooth surface is favorable. Wet electrodes are showing a greatly reduced contact impedance and are therefore to be preferred over dry ones; however, opportunities are seen for improving the electrode performance of dry electrodes by applying pressure to the system, thereby avoiding disadvantages of wet electrodes with fluid administration, drying-out of the electrolyte, and discomfort arising from a "wet feeling".


Asunto(s)
Electrodos , Piel , Textiles , Impedancia Eléctrica , Diseño de Equipo , Humanos
10.
Sensors (Basel) ; 21(5)2021 Feb 27.
Artículo en Inglés | MEDLINE | ID: mdl-33673520

RESUMEN

Animal behavior is an essential element in behavioral neuroscience study. However, most behavior studies in small animals such as fruit flies (Drosophilamelanogaster) have been performed in a limited spatial chamber or by tethering the fly's body on a fixture, which restricts its natural behavior. In this paper, we developed the Transparent Omnidirectional Locomotion Compensator (TOLC) for a freely walking fruit fly without tethering, which enables its navigation in infinite space. The TOLC maintains a position of a fruit fly by compensating its motion using the transparent sphere. The TOLC is capable of maintaining the position error < 1 mm for 90.3% of the time and the heading error < 5° for 80.2% of the time. The inverted imaging system with a transparent sphere secures the space for an additional experimental apparatus. Because the proposed TOLC allows us to observe a freely walking fly without physical tethering, there is no potential injury during the experiment. Thus, the TOLC will offer a unique opportunity to investigate longitudinal studies of a wide range of behavior in an unrestricted walking Drosophila.


Asunto(s)
Conducta Animal , Drosophila melanogaster , Locomoción , Fisiología/instrumentación , Animales , Diseño de Equipo
11.
Appl Opt ; 60(7): 1821-1826, 2021 Mar 01.
Artículo en Inglés | MEDLINE | ID: mdl-33690269

RESUMEN

During the present Sars-CoV-2 pandemic, there has been an increase in the development of UVC disinfection systems. Researchers and members of the lighting community shifted their interests to this new field to help develop systems for disinfecting facemasks and other small equipment. In this paper we show that it is possible to use DIALux to simulate the irradiance distribution provided by a lamp emitting in the UVC range. We will compare the results provided by DIALux with those obtained from Zemax OpticStudio in three different scenarios. We compared the minimum, maximum, and mean irradiance at the detection plane. The differences between the two software were less than 12%, 2%, and 6%, respectively. We also compared the contour maps of isoirradiance lines. We conclude that DIALux is well suited for UVC lighting design in the UVC range. We think that this finding will contribute to increasing the design and manufacturing of new UVC disinfection systems needed to fight against the Sars-CoV-2 pandemic.


Asunto(s)
/prevención & control , Desinfección/métodos , Máscaras/virología , Programas Informáticos , Rayos Ultravioleta , /transmisión , Simulación por Computador , Desinfección/instrumentación , Desinfección/estadística & datos numéricos , Diseño de Equipo , Humanos , Modelos Teóricos , Dispositivos Ópticos , Fenómenos Ópticos , Pandemias/prevención & control
12.
Appl Opt ; 60(7): 1896-1902, 2021 Mar 01.
Artículo en Inglés | MEDLINE | ID: mdl-33690279

RESUMEN

We propose a microlens array-type snapshot hyperspectral microscope system that can provide spatial spectrum sampling according to detector frame rates for the biomedical domain. The system uses a shared optical path design. One path is used to perform direct microscopic imaging with high spatial resolution, while the other is used to collect microscopic images through a microlens array; the images are then spatially cut and reimaged such that they are spaced simultaneously by the prism-grating type hyperspectral imager's dispersion. Rapid acquisition of a three-dimensional data cube measuring 28×14×180 (x×y×λ) can be performed at the detector's frame rate. The system has a spatial resolution of 2.5 µm and can achieve 180-channel sampling of a 100 nm spectrum in the 400-800 nm spectral range with spectral resolution of approximately 0.56 nm. Spectral imaging results from biological samples show that the microlens array-type snapshot hyperspectral microscope system may potentially be applied in real-time biological spectral imaging.


Asunto(s)
Investigación Biomédica , Diagnóstico por Imagen/instrumentación , Microscopía/instrumentación , Diseño de Equipo , Humanos , Imagenología Tridimensional/métodos , Análisis Espectral , Neoplasias Gástricas/patología
13.
Biosensors (Basel) ; 11(3)2021 Feb 28.
Artículo en Inglés | MEDLINE | ID: mdl-33670852

RESUMEN

The diagnosis of respiratory viruses of zoonotic origin (RVsZO) such as influenza and coronaviruses in humans is crucial, because their spread and pandemic threat are the highest. Surface-enhanced Raman spectroscopy (SERS) is an analytical technique with promising impact for the point-of-care diagnosis of viruses. It has been applied to a variety of influenza A virus subtypes, such as the H1N1 and the novel coronavirus SARS-CoV-2. In this work, a review of the strategies used for the detection of RVsZO by SERS is presented. In addition, relevant information about the SERS technique, anthropozoonosis, and RVsZO is provided for a better understanding of the theme. The direct identification is based on trapping the viruses within the interstices of plasmonic nanoparticles and recording the SERS signal from gene fragments or membrane proteins. Quantitative mono- and multiplexed assays have been achieved following an indirect format through a SERS-based sandwich immunoassay. Based on this review, the development of multiplex assays that incorporate the detection of RVsZO together with their specific biomarkers and/or secondary disease biomarkers resulting from the infection progress would be desirable. These configurations could be used as a double confirmation or to evaluate the health condition of the patient.


Asunto(s)
/diagnóstico , Inmunoensayo/métodos , Virus de la Influenza A/aislamiento & purificación , Gripe Humana/diagnóstico , Espectrometría Raman/métodos , /instrumentación , Diseño de Equipo , Humanos , Inmunoensayo/instrumentación , Subtipo H1N1 del Virus de la Influenza A/aislamiento & purificación , Espectrometría Raman/instrumentación
14.
PLoS One ; 16(3): e0247575, 2021.
Artículo en Inglés | MEDLINE | ID: mdl-33730106

RESUMEN

INTRODUCTION: The COVID-19 pandemic has led to widespread shortages of N95 respirators and other personal protective equipment (PPE). An effective, reusable, locally-manufactured respirator can mitigate this problem. We describe the development, manufacture, and preliminary testing of an open-hardware-licensed device, the "simple silicone mask" (SSM). METHODS: A multidisciplinary team developed a reusable silicone half facepiece respirator over 9 prototype iterations. The manufacturing process consisted of 3D printing and silicone casting. Prototypes were assessed for comfort and breathability. Filtration was assessed by user seal checks and quantitative fit-testing according to CSA Z94.4-18. RESULTS: The respirator originally included a cartridge for holding filter material; this was modified to connect to standard heat-moisture exchange (HME) filters (N95 or greater) after the cartridge showed poor filtration performance due to flow acceleration around the filter edges, which was exacerbated by high filter resistance. All 8 HME-based iterations provided an adequate seal by user seal checks and achieved a pass rate of 87.5% (N = 8) on quantitative testing, with all failures occurring in the first iteration. The overall median fit-factor was 1662 (100 = pass). Estimated unit cost for a production run of 1000 using distributed manufacturing techniques is CAD $15 in materials and 20 minutes of labor. CONCLUSION: Small-scale manufacturing of an effective, reusable N95 respirator during a pandemic is feasible and cost-effective. Required quantities of reusables are more predictable and less vulnerable to supply chain disruption than disposables. With further evaluation, such devices may be an alternative to disposable respirators during public health emergencies. The respirator described above is an investigational device and requires further evaluation and regulatory requirements before clinical deployment. The authors and affiliates do not endorse the use of this device at present.


Asunto(s)
/prevención & control , Diseño de Equipo/instrumentación , Filtración/instrumentación , Pandemias/prevención & control , Equipo de Protección Personal , Dispositivos de Protección Respiratoria , Ventiladores Mecánicos , Equipo Reutilizado , Cara , Humanos , Ensayo de Materiales/instrumentación , Exposición Profesional/prevención & control , Impresión Tridimensional/instrumentación , /patogenicidad
15.
Nat Commun ; 12(1): 1744, 2021 03 19.
Artículo en Inglés | MEDLINE | ID: mdl-33741998

RESUMEN

Interferometric scattering microscopy is increasingly employed in biomedical research owing to its extraordinary capability of detecting nano-objects individually through their intrinsic elastic scattering. To significantly improve the signal-to-noise ratio without increasing illumination intensity, we developed photonic resonator interferometric scattering microscopy (PRISM) in which a dielectric photonic crystal (PC) resonator is utilized as the sample substrate. The scattered light is amplified by the PC through resonant near-field enhancement, which then interferes with the <1% transmitted light to create a large intensity contrast. Importantly, the scattered photons assume the wavevectors delineated by PC's photonic band structure, resulting in the ability to utilize a non-immersion objective without significant loss at illumination density as low as 25 W cm-2. An analytical model of the scattering process is discussed, followed by demonstration of virus and protein detection. The results showcase the promise of nanophotonic surfaces in the development of resonance-enhanced interferometric microscopies.


Asunto(s)
Microscopía de Interferencia/instrumentación , Microscopía de Interferencia/métodos , Óptica y Fotónica/instrumentación , Óptica y Fotónica/métodos , Cristalización , Diseño de Equipo , Oro , Procesamiento de Imagen Asistido por Computador , Nanopartículas del Metal , Nanoestructuras , Fotones , Proteínas/aislamiento & purificación , Virión/aislamiento & purificación , Virus/aislamiento & purificación
16.
Medicine (Baltimore) ; 100(9): e24906, 2021 Mar 05.
Artículo en Inglés | MEDLINE | ID: mdl-33655952

RESUMEN

BACKGROUND: The aim of this meta-analysis with trial sequential analysis (TSA) was to evaluate the effect of a polyurethane (PU) tracheal tube cuff on the prevention of ventilator-associated pneumonia (VAP). METHODS: We performed a systematic search using the MEDLINE database through PubMed, Cochrane Central Register of Controlled Trial, SCOPUS, and Web of Science.Randomized controlled trials comparing the incidence of VAP and clinically relevant outcomes between PU cuff tubes and polyvinyl chloride (PVC) cuff tubes in adult patients. Two authors independently extracted study details, patient characteristics, and clinical outcomes such as incidence of VAP, bacterial colonization of tracheal aspirate, duration of mechanical ventilation, ICU stay, and ICU mortality. RESULTS: From 309 studies identified as potentially eligible, six studies with 1226 patients were included in this meta-analysis. All studies compared the incidence of VAP between PU cuffs and PVC cuffs. Use of a PU cuff was not associated with a reduction in VAP incidence (RR = 0.68; 95% CI, 0.45-1.03) with significant statistical heterogeneity (I2 = 65%). The quality of evidence was "very low." According to the TSA, the actual sample size was only 15.8% of the target sample size, and the cumulative Z score did not cross the trial sequential monitoring boundary for benefit. No positive impact was reported for the other relevant outcomes for PU cuffs. CONCLUSIONS: The use of a PU cuff for mechanical ventilation did not prevent VAP. Further trials with a low risk of bias need to be performed.


Asunto(s)
Intubación Intratraqueal/instrumentación , Neumonía Asociada al Ventilador/prevención & control , Poliuretanos , Cloruro de Polivinilo , Respiración Artificial/métodos , Diseño de Equipo , Humanos , Unidades de Cuidados Intensivos
17.
Int Heart J ; 62(2): 416-421, 2021 Mar 30.
Artículo en Inglés | MEDLINE | ID: mdl-33678795

RESUMEN

The retrograde approach has significantly improved the success rates in complex coronary total occlusion (CTO) lesions. It has also become the predominant and important strategy in CTO recanalization. However, unsuccessful crossing of the collateral channels is the strongest predictor of retrograde failure, and adverse collateral channel morphology, including large channel entry angle, could reduce the success rate of collateral channel crossing. Reverse wire technique (RWT) was specifically developed for bifurcation lesions with an extremely angulated side branch, and nowadays, this can be achieved by the support of a dual-lumen catheter (DLC). We report a novel method named "simplified dual-lumen catheter-facilitated RWT" to facilitate markedly angulated collateral channel entry in retrograde CTO intervention. This new technique is simplified by making the reverse bend with the support of a DLC in the aorta instead of outside the guiding catheter, which is feasible, effective, and safe for markedly angulated collateral channel entry in retrograde CTO percutaneous coronary intervention (PCI).


Asunto(s)
Catéteres Cardíacos , Oclusión Coronaria/cirugía , Intervención Coronaria Percutánea/instrumentación , Enfermedad Crónica , Angiografía Coronaria , Oclusión Coronaria/diagnóstico , Diseño de Equipo , Estudios de Factibilidad , Humanos , Masculino , Persona de Mediana Edad , Resultado del Tratamiento
18.
Biomed Instrum Technol ; 55(1): 41-43, 2021 Jan 01.
Artículo en Inglés | MEDLINE | ID: mdl-33690818

RESUMEN

Split septum medical devices are used in tubing for intravenous (IV) fluid administration-an extremely common clinical task. These tubing caps contain a needleless, valveless system that allows fluid to flow directly through the lumen of the catheter but prevents backflow of fluid or blood when the tubing extension is not connected. We experienced complete failure of a needle-free connector extension set with a Luer-access split septum device in multiple patients due to the split septum remaining fused and essentially unsplit despite being connected on both ends. This led to an adverse event in a patient due to repeated unnecessary IV insertion attempts. This case shows how even the simplest of devices can malfunction and highlights the need for vigilance in clinical practice.


Asunto(s)
Catéteres de Permanencia , Diseño de Equipo , Humanos , Infusiones Intravenosas
20.
Math Biosci Eng ; 18(2): 1513-1528, 2021 01 28.
Artículo en Inglés | MEDLINE | ID: mdl-33757196

RESUMEN

The internet of things (IoT) and deep learning are emerging technologies in diverse research fields, including the provision of IT services in medical domains. In the COVID-19 era, intelligent medication behavior monitoring systems for stable patient monitoring are further required, because many patients cannot easily visit hospitals. Several previous studies made use of wearable devices to detect medication behaviors of patients. However, the wearable devices cause inconvenience while equipping the devices. In addition, they suffer from inconsistency problems due to errors of measured values. We devise a medication behavior monitoring system that uses the IoT and deep learning to avoid sensing errors and improve user experiences by effectively detecting various activities of patients. Based on the real-time operation of our proposed IoT device, the proposed solution processes captured images of patents via OpenPose to check medication situations. The proposed system identifies medication status on time by using a human activity recognition scheme and provides various notifications to patients' mobile devices. To support reliable communication between our system and doctors, we employ MQTT protocol with periodic data transmissions. Thus, the measured information of patient's medication status is transmitted to the doctors so that they can periodically perform remote treatments. Experimental results show that all medication behaviors are accurately detected and notified to the doctor efficiently, improving the accuracy of monitoring the patient's medication behavior.


Asunto(s)
/tratamiento farmacológico , Aprendizaje Profundo , Cumplimiento de la Medicación , Monitoreo Fisiológico/métodos , Ingeniería Biomédica , Sistemas de Computación , Terapia por Observación Directa , Diseño de Equipo , Humanos , Internet de las Cosas , Cumplimiento de la Medicación/psicología , Cumplimiento de la Medicación/estadística & datos numéricos , Monitoreo Fisiológico/instrumentación , Monitoreo Fisiológico/estadística & datos numéricos , Redes Neurales de la Computación , Pandemias , Programas Informáticos , Dispositivos Electrónicos Vestibles
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