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1.
J Glob Health ; 10(1): 010804, 2020 Jun.
Artículo en Inglés | MEDLINE | ID: mdl-32257168

RESUMEN

Background: Suboptimal health status (SHS) is an intermediate health status between ideal health and illness. As a determinant of cardiovascular disease and stroke, SHS is hypothesized to be associated with the development of cognitive impairment and dementia. This study aimed to investigate whether individuals with SHS have poor cognitive ability based on a community-based cohort in northern Chinese population. Methods: 3524 participants who were enrolled in Jidong cohort 2015 in Tangshan City were investigated in this study. Cognitive function was measured with the Mini-Mental State Examination (MMSE). SHS level was evaluated using a self-reporting Suboptimal Health Status Questionnaire-25 (SHSQ-25). The relationship between SHS and cognitive function was analyzed with logistic regression analysis, by which odds ratio (OR) and 95% confidence interval (CI) were calculated. Results: The prevalence of cognitive impairment was 3.4% (121/3524) in our study, with the prevalence rates of 1.9% (34/1750) among men and 4.9% (87/1774) in women. The medians of total score of MMSE were 28 (interquartile range (IQR) = 27-29) in the SHS group, and 29 (IQR = 27-30) in the ideal health group. Logistic regression analysis showed that SHS was significantly correlated with cognitive impairment (adjusted OR = 2.936, 95% CI = 1.428-6.033). With regard to gender, the OR was 5.067 (95% CI = 1.346-19.068) in men, which was higher than that in women (OR = 2.324, 95% CI = 1.130-4.779). Conclusions: SHS might be a risk factor for cognitive function in northern Chinese population. Early screening of SHS individuals, as well as urgent treatment of SHS might contribute to the prevention of cognitive impairment.


Asunto(s)
Cognición/fisiología , Disfunción Cognitiva/epidemiología , Disparidades en el Estado de Salud , Estado de Salud , Calidad de Vida/psicología , Adulto , Distribución por Edad , Anciano , Anciano de 80 o más Años , Grupo de Ascendencia Continental Asiática , Índice de Masa Corporal , Disfunción Cognitiva/psicología , Estudios de Cohortes , Estudios Transversales , Femenino , Humanos , Estilo de Vida , Masculino , Pruebas de Estado Mental y Demencia , Persona de Mediana Edad , Distribución por Sexo , Fumar/epidemiología , Factores Socioeconómicos , Encuestas y Cuestionarios
2.
Medicine (Baltimore) ; 99(16): e19620, 2020 Apr.
Artículo en Inglés | MEDLINE | ID: mdl-32311931

RESUMEN

For the diagnosis of mild cognitive impairment (MCI) and Alzheimer disease (AD), variable neuroimaging and neuropsychological tests have been used. We aimed to evaluate the correlation of neuropsychological domain with new amyloid positron emission tomography (PET) study and to validate the availability of new PET tracer.We enrolled 20 patients who underwent C-PiB-PET/CT, new PET tracer F-FC119S PET/CT from November, 2014 to July, 2015. Among them, 10 patients were diagnosed with AD and 10 patients with MCI. The current version of Seoul Neuropsychological Screening Battery (SNSB) II was performed for cognitive evaluation. Each parameter of SNSB was compared between 2 patient groups. Spearman correlation analysis between value of SNSB domain and standardized uptake value ratio (SUVR) of PET was also performed.The AD group presented significant poor z-score in Korean-Boston Naming Test(K-BNT) (P = .01),copy score of Rey Complex Figure Test (RCFT) (P = .049), immediate (P = .028)and delayed memory of Seoul Verbal Learning Test (SVLT) (P = .028), recognition of RCFT (P = .004), "animal" of Controlled Oral Word Association Test (COWAT) (P = .041), color reading of Korean-Color Word Stroop test (K-CWST) (P = .014), and Digit Symbol Coding (DSC) (P = .007) compared with MCI group. That means, except attention domain, all other cognitive domains were relatively impaired in AD compared with MCI. In correlation analysis, we found that poor performances on copy score of RCFT in MCI groups were associated with great beta amyloid burden in frontal area in both C-PiB-PET/CT and F-FC119S PET/CT. In AD group, F-FC119S PET presented more extensive correlation in each cognitive domain with multiple cortical areas compared with C-PiB-PET.The degree of amyloid burden assessed on F-FC119S PET was significantly correlated with neuropsychological test in AD, and also MCI patients. The combination of neuropsychological evaluation with novel F-FC119S PET/CT can be used for valid biomarker for MCI and AD.


Asunto(s)
Enfermedad de Alzheimer/diagnóstico por imagen , Amiloide/metabolismo , Disfunción Cognitiva/diagnóstico por imagen , Tomografía Computarizada por Tomografía de Emisión de Positrones/métodos , Anciano , Anciano de 80 o más Años , Enfermedad de Alzheimer/metabolismo , Enfermedad de Alzheimer/psicología , Compuestos de Anilina , Radioisótopos de Carbono , Disfunción Cognitiva/metabolismo , Disfunción Cognitiva/psicología , Femenino , Radioisótopos de Flúor , Humanos , Masculino , Persona de Mediana Edad , Neuroimagen/métodos , Pruebas Neuropsicológicas , Trazadores Radiactivos , Tiazoles
5.
Am J Nurs ; 120(3): 72, 2020 03.
Artículo en Inglés | MEDLINE | ID: mdl-32079807

RESUMEN

A patient's mysterious (and infectious) hope gives her meaning and seems to bolster her strength.


Asunto(s)
Esperanza , Disfunción Cognitiva/complicaciones , Disfunción Cognitiva/psicología , Femenino , Humanos , Neoplasias Ováricas/complicaciones , Neoplasias Ováricas/psicología
6.
J Agric Food Chem ; 68(8): 2381-2392, 2020 Feb 26.
Artículo en Inglés | MEDLINE | ID: mdl-32037817

RESUMEN

Increasing level of inflammation and oxidative stress could lead to memory impairment. The purpose of this study was to determine the neuroprotective effects of walnut peptides against memory deficits induced by lipopolysaccharide (LPS) in mice and further to explore the underlying anti-inflammatory mechanisms against LPS-elicited inflammation in BV-2 cells. Results showed that walnut protein hydrolysate (WPH) and its low-molecular-weight fraction (WPHL) could ameliorate the memory deficits induced by LPS via normalizing the inflammatory response and oxidative stress in brain, especially WPHL. Furthermore, 18 peptides with anti-inflammatory activities on LPS-activated BV-2 cells were identified from WPHL and it was found that Trp, Gly, and Leu residues in peptides might contribute to the anti-inflammation. Meanwhile, the strong anti-inflammatory effects of LPF, GVYY, and APTLW might be related to their hydrophobic and aromatic amino acid residues as well. LPF, GVYY, and APTLW could reduce the content of proinflammatory mediators and cytokines by downregulating related enzyme expressions and mRNA expressions. Additionally, ROS and mitochondria homeostasis might also contribute to their anti-inflammatory effects.


Asunto(s)
Antiinflamatorios/administración & dosificación , Disfunción Cognitiva/tratamiento farmacológico , Juglans/química , Estrés Oxidativo/efectos de los fármacos , Péptidos/administración & dosificación , Animales , Antiinflamatorios/química , Disfunción Cognitiva/inducido químicamente , Disfunción Cognitiva/inmunología , Disfunción Cognitiva/psicología , Humanos , Lipopolisacáridos/efectos adversos , Aprendizaje por Laberinto , Ratones , Peso Molecular , Fármacos Neuroprotectores/administración & dosificación , Fármacos Neuroprotectores/química , Nueces/química , Péptidos/química
7.
Dev Med Child Neurol ; 62(3): 283-289, 2020 03.
Artículo en Inglés | MEDLINE | ID: mdl-32010976

RESUMEN

Children with cerebral palsy (CP) have an increased risk of cognitive impairments. This narrative review of the literature discusses assessment of cognition in children with CP, presents the most salient characteristics of cognitive functioning pertaining to each subtype, and discusses the relationships between brain injury, functioning, and intervention from a developmental perspective. A search for original studies of cognitive functioning in children with different subtypes of CP was performed. The search resulted in 81 unique hits. There were few studies with a representative sample of children with CP where all participants were individually assessed. Cognitive functioning in children with the most severe motor impairments were often assumed and not assessed. Furthermore, there was a confounding of IQ below 70 and intellectual disability, possibly leading to an overestimation of the prevalence of intellectual disability. Longitudinal neuropsychological studies, including also very young children and those with the most severe speech and motor impairments, as well as intervention studies, are called for. WHAT THIS PAPER ADDS: Few studies have assessed cognition in a representative sample of children with cerebral palsy. Cognition in children with severe motor impairment is often assumed, not assessed. Lack of assessment may lead to overestimating the prevalence of intellectual disability. Lowered cognitive functioning in older children highlights the need for longitudinal studies.


Asunto(s)
Parálisis Cerebral/psicología , Cognición/fisiología , Disfunción Cognitiva/psicología , Parálisis Cerebral/complicaciones , Niño , Disfunción Cognitiva/complicaciones , Humanos , Discapacidad Intelectual/complicaciones , Discapacidad Intelectual/psicología , Pruebas Neuropsicológicas
8.
J Agric Food Chem ; 68(10): 3099-3111, 2020 Mar 11.
Artículo en Inglés | MEDLINE | ID: mdl-32067456

RESUMEN

Sesamol, a lignan in sesame, possesses several bioactivities, such as antioxidation, anti-inflammation, and neuroprotective capability. In this study, the effects of sesamol on aging-caused cognitive defects are investigated. Twelve-month-old mice were treated with sesamol (0.1%, w/w) as dietary supplementation for 12 weeks. Behavioral tests revealed that sesamol improved aging-associated cognitive impairments. Sesamol decreased aging-induced oxidative stress via suppression of malondialdehyde production and increased antioxidant enzymes. Histological staining showed that sesamol treatment improved aging-induced neuronal damage and synaptic dysfunction in the hippocampus. Furthermore, sesamol significantly reduced aging-induced neuroinflammation by inhibiting the microglial overactivation and inflammatory cytokine expressions. Meanwhile, the accumulation of Aß1-42 was reduced by sesamol treatment. Moreover, sesamol protected the gut barrier integrity and reduced LPS release, which was highly associated with its beneficial effects on behavioral and inflammatory changes. In conclusion, our findings indicated that the use of sesamol is feasible in the treatment of aging-related diseases.


Asunto(s)
Envejecimiento/efectos de los fármacos , Benzodioxoles/administración & dosificación , Disfunción Cognitiva/tratamiento farmacológico , Fármacos Neuroprotectores/administración & dosificación , Fenoles/administración & dosificación , Envejecimiento/inmunología , Envejecimiento/psicología , Péptidos beta-Amiloides/inmunología , Animales , Disfunción Cognitiva/inmunología , Disfunción Cognitiva/psicología , Hipocampo/efectos de los fármacos , Hipocampo/inmunología , Humanos , Masculino , Malondialdehído/inmunología , Ratones , Microglía/efectos de los fármacos , Microglía/inmunología , Estrés Oxidativo/efectos de los fármacos
9.
Am J Clin Nutr ; 111(3): 590-600, 2020 03 01.
Artículo en Inglés | MEDLINE | ID: mdl-31912155

RESUMEN

BACKGROUND: Walnut consumption counteracts oxidative stress and inflammation, 2 drivers of cognitive decline. Clinical data concerning effects on cognition are lacking. OBJECTIVES: The Walnuts And Healthy Aging study is a 2-center (Barcelona, Spain; Loma Linda, CA) randomized controlled trial examining the cognitive effects of a 2-y walnut intervention in cognitively healthy elders. METHODS: We randomly allocated 708 free-living elders (63-79 y, 68% women) to a diet enriched with walnuts at ∼15% energy (30-60 g/d) or a control diet (abstention from walnuts). We administered a comprehensive neurocognitive test battery at baseline and 2 y. Change in the global cognition composite was the primary outcome. We performed repeated structural and functional brain MRI in 108 Barcelona participants. RESULTS: A total of 636 participants completed the intervention. Besides differences in nutrient intake, participants from Barcelona smoked more, were less educated, and had lower baseline neuropsychological test scores than those from Loma Linda. Walnuts were well tolerated and compliance was good. Modified intention-to-treat analyses (n = 657) uncovered no between-group differences in the global cognitive composite, with mean changes of -0.072 (95% CI: -0.100, -0.043) in the walnut diet group and -0.086 (95% CI: -0.115, -0.057) in the control diet group (P = 0.491). Post hoc analyses revealed significant differences in the Barcelona cohort, with unadjusted changes of -0.037 (95% CI: -0.077, 0.002) in the walnut group and -0.097 (95% CI: -0.137, -0.057) in controls (P = 0.040). Results of brain fMRI in a subset of Barcelona participants indicated greater functional network recruitment in a working memory task in controls. CONCLUSIONS: Walnut supplementation for 2 y had no effect on cognition in healthy elders. However, brain fMRI and post hoc analyses by site suggest that walnuts might delay cognitive decline in subgroups at higher risk. These encouraging but inconclusive results warrant further investigation, particularly targeting disadvantaged populations, in whom greatest benefit could be expected.This trial was registered at clinicaltrials.gov as NCT01634841.


Asunto(s)
Disfunción Cognitiva/dietoterapia , Juglans/metabolismo , Nueces/metabolismo , Anciano , Encéfalo/diagnóstico por imagen , Disfunción Cognitiva/diagnóstico por imagen , Disfunción Cognitiva/metabolismo , Disfunción Cognitiva/psicología , Femenino , Envejecimiento Saludable , Humanos , Imagen por Resonancia Magnética , Masculino , Memoria , Persona de Mediana Edad , España
10.
Psychol Aging ; 35(1): 1-7, 2020 Feb.
Artículo en Inglés | MEDLINE | ID: mdl-31985244

RESUMEN

Consistent with the long history within Psychology and Aging of publishing high impact articles on family caregiving, the current Special Section includes 5 articles that provide important advances, in knowledge and in methodological sophistication, to the study of cognitive difficulty, impairment and family caregiving. One study used daily diary data over 14 days to conduct microlongitudinal analyses of the prospective impact of everyday memory failures on negative affect and marital interactions in older couples. Also relying on dyadic data, 2 other articles addressed the impact of caregiving on family members, including a study of the effects of transitioning to family caregiving over time on well-being in older husbands and wives, and a comparison of primary and secondary caregivers. Together, these articles represent important methodological advances in terms of the use of longitudinal data to study the effects of transition to cognitive impairment and spousal caregiving within the couple, and the inclusion of multiple caregivers to illustrate the impacts of caregiving in the broader family. In addition, two articles examined issues in clinical intervention for caregivers. Both articles offer new insights about the effectiveness of caregiver interventions, with the former focusing on the relative merits of offering intervention components in a flexible way over the manualized approach, and the latter a comprehensive systematic review and meta-analysis to tease out the relative utility of different intervention characteristics and approaches, with a new lens to look at psychoeducational programs. The implications of these articles for family caregiving and further research advances are discussed. (PsycINFO Database Record (c) 2020 APA, all rights reserved).


Asunto(s)
Cuidadores/psicología , Disfunción Cognitiva/psicología , Familia/psicología , Estrés Psicológico/psicología , Anciano , Femenino , Humanos , Masculino , Estudios Prospectivos
11.
J Agric Food Chem ; 68(1): 206-212, 2020 Jan 08.
Artículo en Inglés | MEDLINE | ID: mdl-31808686

RESUMEN

The present study aimed to investigate the effects of matured hop bitter acids (MHBAs) on human cognition, mental fatigue, and mood state. In this randomized double-blind placebo-controlled study, 60 healthy adults (age 45-64 years) with self-awareness of cognitive decline were randomly divided into 2 groups and received either orally administered MHBAs (35 mg/day) or placebo for 12 weeks. Cognitive functions and mental states were assessed using neuropsychological tests or questionnaires at baseline and weeks 6 and 12 of the intervention. The change in verbal fluency score at week 6 compared with that at baseline was significantly higher in the MHBAs-treated group compared with that in the placebo group (P = 0.034), and Stroop test score at week 12 was significantly lower in the MHBAs-treated group compared with the placebo group (P = 0.019). Furthermore, subjective fatigue and anxiety at week 12 were significantly improved in the MHBAs-treated group (P = 0.008 and 0.043, respectively) compared with the placebo group. This is the first study to evaluate the effects of bitter ingredients in beer on cognition, subjective mood, and mental fatigue in a clinical trial. Our findings suggest that hop-derived bitter acids might be beneficial for cognition and mood state.


Asunto(s)
Ácidos/metabolismo , Cerveza/análisis , Cognición , Disfunción Cognitiva/metabolismo , Disfunción Cognitiva/psicología , Humulus/química , Humulus/metabolismo , Extractos Vegetales/metabolismo , Ácidos/análisis , Afecto , Femenino , Voluntarios Sanos , Humanos , Masculino , Persona de Mediana Edad , Pruebas Neuropsicológicas
12.
J Stroke Cerebrovasc Dis ; 29(2): 104513, 2020 Feb.
Artículo en Inglés | MEDLINE | ID: mdl-31784380

RESUMEN

BACKGROUND AND PURPOSE: Slowed Information Processing Speed (IPS) is a commonly reported cognitive deficit following stroke, affecting up to 50% to 70 % of stroke survivors. IPS has a major influence on poststroke cognitive dysfunction, affecting quality of life and increasing dependence on others. Few studies have examined predictors of slow IPS after stroke, and there is a paucity of data in terms of long-term prevalence. This study examined baseline predictors associated with long-term slow IPS in a population-based stroke incidence cohort, 4 years after stroke onset. METHODS: Adults with stroke (n = 133, m = 71.1 ± 13.5 years) completed the Symbol Digit Modalities Test (SDMT) at 4 years poststroke. Baseline predictors were obtained within 2 weeks of the acute event. Multivariate regression linear and logistic models were used to identify baseline predictors (reported as OR with 95%CI) and prevalence of impaired IPS at 4-years. RESULTS: 51% of people with stroke had low scores on the SDMT as indicated by a score of -1.0 SD to -2.5 SD (ranging from low to very low respectively). There were significant associations between slow IPS at 4-years after controlling for age and education level and the following baseline factors: older age (>75 years) (OR 3.03, 95% CI .9-9.3,P = .05), previous stroke (OR 2.74, 95% CI 1.0-7.4,P = .05), high cholesterol (OR 2.72, 95% CI 1.3-5.4,p = .01), hypertension (OR 1.82, 95% CI 0.9-3.6,p = .05), and presence of coronary artery disease (OR 3.35, 95% CI 1.6-9.6,P = .01), or arrhythmia (OR 4.40, 95% CI 1.5-12.4,P = .01). CONCLUSIONS: Even after 4-years poststroke, slowed IPS is highly prevalent, with comorbid vascular risk factors significantly contributing to persistent impaired IPS. Early identification of adults who are at higher risk of deficits in IPS is vital to targeting the timely delivery of cognitive rehabilitation interventions, improving overall outcomes.


Asunto(s)
Encéfalo/fisiopatología , Cognición , Disfunción Cognitiva/rehabilitación , Rehabilitación de Accidente Cerebrovascular , Accidente Cerebrovascular/terapia , Adulto , Anciano , Anciano de 80 o más Años , Disfunción Cognitiva/epidemiología , Disfunción Cognitiva/fisiopatología , Disfunción Cognitiva/psicología , Femenino , Estudios de Seguimiento , Humanos , Masculino , Persona de Mediana Edad , Nueva Zelanda/epidemiología , Prevalencia , Estudios Prospectivos , Recuperación de la Función , Factores de Riesgo , Accidente Cerebrovascular/epidemiología , Accidente Cerebrovascular/fisiopatología , Accidente Cerebrovascular/psicología , Factores de Tiempo , Resultado del Tratamiento , Adulto Joven
13.
J Stroke Cerebrovasc Dis ; 29(2): 104576, 2020 Feb.
Artículo en Inglés | MEDLINE | ID: mdl-31839546

RESUMEN

BACKGROUND: Little is known on factors influencing cognitive function in rural communities. Using the Atahualpa Project cohort, we aimed to assess whether the carotid intima-media thickness (cIMT) - used as a surrogate of extracranial carotid atherosclerosis - is associated with cognitive performance and further decline in community-dwelling adults living in a rural setting. METHODS: The study included Atahualpa residents aged greater than or equal to 40 years who had ultrasound examination of the extracranial carotid arteries and a baseline Montreal Cognitive Assessment (MoCA), as well as the subset of individuals who also had a follow-up MoCA at least 1 year after baseline. Relationship between cIMT and cognitive function was assessed by means of generalized linear and longitudinal models, adjusted for relevant covariates. Mediation analysis was utilized to establish the proportion of the effect between increased cIMT and cognitive performance, which is mediated by age. RESULTS: A total of 561 individuals were included for the cross-sectional study, and 510 of them were assessed for the prospective cohort. Univariate analysis showed a significant association between increased cIMT and worse cognitive performance (P < .001), which vanishes after considering the effect of age and low scholarity. Causal mediation analysis confirms that age captures 82.6% (95% C.I.: 63.9% to 100%) of the effect of this association. There was no relationship between increased cIMT and cognitive decline in the follow-up. CONCLUSIONS: In this rural population, the association between increased cIMT and cognitive dysfunction is mostly mediated by increasing age.


Asunto(s)
Enfermedades de las Arterias Carótidas/diagnóstico por imagen , Grosor Intima-Media Carotídeo , Cognición , Envejecimiento Cognitivo/psicología , Disfunción Cognitiva/psicología , Salud Rural , Adulto , Factores de Edad , Anciano , Anciano de 80 o más Años , Enfermedades de las Arterias Carótidas/epidemiología , Disfunción Cognitiva/diagnóstico , Disfunción Cognitiva/epidemiología , Estudios Transversales , Ecuador/epidemiología , Femenino , Humanos , Estudios Longitudinales , Masculino , Persona de Mediana Edad , Valor Predictivo de las Pruebas , Pronóstico , Estudios Prospectivos , Medición de Riesgo , Factores de Riesgo , Factores de Tiempo
14.
Neurology ; 94(6): e613-e625, 2020 02 11.
Artículo en Inglés | MEDLINE | ID: mdl-31879275

RESUMEN

OBJECTIVES: Epigenetic modifications are closely linked with aging, but their relationship with cognition remains equivocal. Given known sex differences in epigenetic aging, we explored sex-specific associations of 3 DNA methylation (DNAm)-based measures of epigenetic age acceleration (EAA) with baseline and longitudinal change in cognitive performance among middle-aged urban adults. METHODS: We used exploratory data from a subgroup of participants in the Healthy Aging in Neighborhoods of Diversity across the Life Span study with complete DNA samples and whose baseline ages were >50.0 years (2004-2009) to estimate 3 DNAm EAA measures: (1) universal EAA (AgeAccel); (2) intrinsic EAA (IEAA); and (3) extrinsic EAA (EEAA). Cognitive performance was measured at baseline visit (2004-2009) and first follow-up (2009-2013) with 11 test scores covering global mental status and specific domains such as learning/memory, attention, visuospatial, psychomotor speed, language/verbal, and executive function. A series of mixed-effects regression models were conducted adjusting for covariates and multiple testing (n = 147-156, ∼51% men, k = 1.7-1.9 observations/participant, mean follow-up time ∼4.7 years). RESULTS: EEAA, a measure of both biological age and immunosenescence, was consistently associated with greater cognitive decline among men on tests of visual memory/visuoconstructive ability (Benton Visual Retention Test: γ11 = 0.0512 ± 0.0176, p = 0.004) and attention/processing speed (Trail-Making Test, part A: γ11 = 0.219 ± 0.080, p = 0.007). AgeAccel and IEAA were not associated with cognitive change in this sample. CONCLUSIONS: EEAA capturing immune system cell aging was associated with faster decline among men in domains of attention and visual memory. Larger longitudinal studies are needed to replicate our findings.


Asunto(s)
Envejecimiento/genética , Disfunción Cognitiva/genética , Metilación de ADN , Epigénesis Genética , Anciano , Envejecimiento/psicología , Atención , Disfunción Cognitiva/psicología , Función Ejecutiva , Femenino , Humanos , Inmunosenescencia/genética , Estudios Longitudinales , Masculino , Memoria , Persona de Mediana Edad , Pruebas Neuropsicológicas , Desempeño Psicomotor , Factores Sexuales , Población Urbana
15.
Gerokomos (Madr., Ed. impr.) ; 30(4): 172-175, dic. 2019.
Artículo en Español | IBECS | ID: ibc-188204

RESUMEN

Objetivo: Determinar la relación entre hipertensión arterial y diabetes mellitus tipo 2 con el deterioro cognitivo de adultos mayores de un centro comunitario en Chile. Método: Estudio correlacional de corte transversal. La muestra correspondió a 80 adultos mayores. Se aplicó un cuestionario recolector de datos y el instrumento Mini-Examen del Estado Mental (MMSE). Resultados: la puntuación media obtenida en el MMSE fue de 25,04 ± 3,84 puntos. Se encontró relación estadísticamente significativa entre la puntuación obtenida en el MMSE con las variables edad, sexo, nivel socioeconómico, nivel educacional, situación de pareja y tener diabetes mellitus tipo 2. Conclusión: Es importante que el equipo sanitario pueda proteger el acceso a la atención médica en este grupo etario, favoreciendo la adherencia a los controles y tratamientos, tanto de enfermedades no transmisibles como evaluaciones del estado mental, con derivaciones oportunas, favoreciendo instancias de estimulación cognitiva


Objective: To determine the relationship between hypertension and type 2 diabetes mellitus with the cognitive deterioration of older adults of a community center in Chile. Methods: Cross-sectional correlation study. The sample corresponded to 80 older adults. A data collection questionnaire and the MiniMental State Examination (MMSE) were applied. Results: The average score obtained in the MMSE was 25.04 ± 3.84 points. We found statistically significant relationship between scores obtained in the MMSE with the variables age, sex, socioeconomic level, educational level, partner situation and possess diabetes mellitus type 2. Conclusion: It is important that the health team can protect the access of healthcare in this age group, favoring the adherence to the controls and treatments, both of noncommunicable diseases, as assessments of the mental state, with derivations Opportune, favoring instances of cognitive stimulation


Asunto(s)
Humanos , Masculino , Femenino , Anciano , Disfunción Cognitiva/complicaciones , Hipertensión/complicaciones , Diabetes Mellitus Tipo 2/complicaciones , Servicios de Salud Comunitaria/organización & administración , Disfunción Cognitiva/psicología , Chile , Estudios Transversales , Encuestas y Cuestionarios , Salud Mental , Condiciones Sociales
16.
Cyberpsychol Behav Soc Netw ; 22(12): 761-765, 2019 Dec.
Artículo en Inglés | MEDLINE | ID: mdl-31841649

RESUMEN

Traumatic brain injury (TBI) and post-traumatic stress disorder (PTSD) are highly prevalent, and frequently comorbid, among active and retired military service members. Both TBI and PTSD may contribute to impaired cognitive function, but it remains insufficiently clear what the relative impact of each is on overall cognition and whether multiple TBIs may further impair cognitive function. To understand the relative impact of TBI and symptoms of PTSD on cognitive function we examined data from 326 active or retired military service members, or dependents, either with or without a history of TBI, using questionnaires and the NIH Toolbox Cognitive Battery (NIH-TB), a brief iPad-based assessment that measures the cognitive domains most important to daily functioning. The NIH-TB was developed for use as a "common currency" among research studies, and was more recently adapted to the iPad for ease of use. To our knowledge, this is the first report of its application to evaluate the relative impact of TBI and PTSD. Our results indicate that cognitive function remains largely intact after multiple TBIs if symptoms of PTSD are not evident, and that measures of literacy and overall intelligence are relatively impervious to both TBI and PTSD. When cognitive impairment is observed after TBI, it is predominantly associated with the presence of significant symptoms of PTSD in most domains. However, TBI alone may impair some aspects of executive function. These findings need to be validated in other populations.


Asunto(s)
Lesiones Traumáticas del Encéfalo/psicología , Cognición , Disfunción Cognitiva/psicología , Personal Militar/psicología , Enfermedades Profesionales/psicología , Trastornos por Estrés Postraumático/psicología , Adulto , Disfunción Cognitiva/diagnóstico , Comorbilidad , Femenino , Humanos , Masculino , Persona de Mediana Edad , Pruebas Neuropsicológicas , Enfermedades Profesionales/diagnóstico , Encuestas y Cuestionarios
17.
Biomed Res Int ; 2019: 4347281, 2019.
Artículo en Inglés | MEDLINE | ID: mdl-31886216

RESUMEN

The age of the population is shifting toward the elderly range, which may lead to an increased risk of mild cognitive impairment (MCI). The aims of this study are to evaluate the cognitive function in elderly people using the Montreal Cognitive Assessment (MoCA), to identify the relationship between cognitive function and different characteristics, and to evaluate the efficacy of the intervention after six months of cognitive training. In this study, we included 2886 subjects aged ≧60 years in the baseline survey, and 140 subjects with MCI who participated in the baseline survey were randomly divided into an intervention group (N = 70) and a control group (N = 70). The control group was not provided any intervention measures, and the intervention group was administered cognitive training. The education level, monthly income, sleep time, exercise time, reading times, and time spent engaging in community activities and performing housework were positively correlated with MoCA scores, but age was negatively correlated with MoCA scores. The total MoCA score of the intervention group increased from 19.77 ± 2.24 points to 21.09 ± 2.20 points after six months of cognitive training, but the score of the control group decreased from 20.41 ± 2.10 points to 19.17 ± 2.57 points. The two-way repeated-measures ANOVA revealed a very significant effect of the interaction between time and cognitive training on the total MoCA score. Seventeen participants in the intervention group improved to normal levels, and no participants progressed to dementia after six months of cognitive training. Thus, the efficacy of the intervention was statistically significant. Our study concludes that older age is associated with a cognitive decline. Factors that are more likely to protect against cognitive decline included a higher education level and monthly income, sufficient sleep time, regular physical exercise and reading, frequently engaging in community activities, and continuing to perform housework. Moreover, the cognitive training intervention is effective and may help to decrease the deterioration of cognitive function in patients with MCI, and the interaction between intervention time and cognitive training significantly improves cognitive function.


Asunto(s)
Cognición , Terapia Cognitivo-Conductual , Disfunción Cognitiva , Demencia , Terapia por Ejercicio , Anciano , Disfunción Cognitiva/fisiopatología , Disfunción Cognitiva/psicología , Disfunción Cognitiva/terapia , Demencia/fisiopatología , Demencia/psicología , Demencia/terapia , Femenino , Humanos , Masculino , Persona de Mediana Edad
18.
Psychol Aging ; 34(7): 954-977, 2019 Nov.
Artículo en Inglés | MEDLINE | ID: mdl-31682146

RESUMEN

This meta-analysis examined how performance on various cognitive domains of neuropsychological functioning can contribute to predicting progression to dementia from mild cognitive impairment (MCI) or subjective memory complaints. Studies performed between the years of 1997 and 2018 were identified through a search of the electronic databases Medline and PsycINFO. Data from the articles identified were pooled to determine standardized mean differences, calculated as Hedges g, using a random-effects model. Twenty-four studies were included in the analysis. The majority of studies examined the progression of amnestic mild cognitive impairment (aMCI) to Alzheimer's disease (AD). Nonprogressors performed significantly better than did progressors in the domains of divided attention, executive function, expressive language, immediate recall, processing speed, delayed recall, visuospatial/constructional ability, working memory, and sustained attention. These findings indicate that individuals with MCI or subjective memory complaints who do not progress to dementia, perform better at baseline as compared with individuals that progress to dementia on a range of neuropsychological measures, and lends further support to the contention that neuropsychological assessment can make important contributions to predicting progression to dementia while individuals are still in the MCI or subjective memory complaint stage. (PsycINFO Database Record (c) 2019 APA, all rights reserved).


Asunto(s)
Enfermedad de Alzheimer/psicología , Disfunción Cognitiva/psicología , Demencia/etiología , Pruebas Neuropsicológicas/normas , Anciano , Demencia/patología , Progresión de la Enfermedad , Femenino , Humanos , Masculino
19.
Rev Med Suisse ; 15(671): 2110-2113, 2019 Nov 13.
Artículo en Francés | MEDLINE | ID: mdl-31742943

RESUMEN

In the absence of curative pharmaceutical treatment for evolving cognitive impairment, non-drug interventions are key components in patients' and caregivers' care. These interventions, when combined and adapted to the needs of the patient and the caregiver, allow for maintaining functional autonomy, decreasing caregiver burden and, possibly, slowing down cognitive decline. An on-going study in Suisse Romande (INDID-MCI-QOL) assesses the effect of the number and type of interventions conducted over a year on the evolution of physical, psychological and cognitive health in this population.


Asunto(s)
Cuidadores/psicología , Disfunción Cognitiva/psicología , Disfunción Cognitiva/terapia , Calidad de Vida , Humanos
20.
J Headache Pain ; 20(1): 103, 2019 Nov 11.
Artículo en Inglés | MEDLINE | ID: mdl-31711415

RESUMEN

BACKGROUND: Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) manifests principally as a suite of cognitive impairments, particularly in the executive domain. Executive functioning requires the dynamic coordination of neural activity over large-scale networks. It remains unclear whether changes in resting-state brain functional network connectivity and regional homogeneities (ReHos) underly the mechanisms of executive dysfunction evident in CADASIL patients. METHODS: In this study, 22 CADASIL patients and 44 matched healthy controls underwent resting-state functional magnetic resonance imaging (fMRI). Independent component analysis (ICA) was used to measure functional brain network connectivity, and ReHos were calculated to evaluate local brain activities. We used seed-based functional connectivity (FC) analyses to determine whether dysfunctional areas (as defined by ReHos) exhibited abnormal FC with other brain areas. Relationships among the mean intra-network connectivity z-scores of dysfunctional areas within functional networks, and cognitive scores were evaluated using Pearson correlation analyses. RESULTS: Compared to the controls, CADASIL patients exhibited decreased intra-network connectivity within the bilateral lingual gyrus (LG) and the right cuneus (CU) (thus within the visual network [VIN)], and within the right precuneus (Pcu), inferior frontal gyrus (IFG), and precentral gyrus (thus within the frontal network [FRN]). Compared to the controls, patients also exhibited significantly lower ReHos in the right precuneus and cuneus (Pcu/CU), visual association cortex, calcarine gyri, posterior cingulate, limbic lobe, and weaker FC between the right Pcu/CU and the bilateral parahippocampal gyrus (PHG), and between the right Pcu/CU and the right postcentral gyrus. Notably, the mean connectivity z-scores of the bilateral LG and the right CU within the VIN were positively associated with compromised attention, calculation and delayed recall as revealed by tests of the various cognitive domains explored by the Mini-Mental State Examination. CONCLUSIONS: The decreases in intra-network connectivity within the VIN and FRN and reduced local brain activity in the posterior parietal area suggest that patients with CADASIL may exhibit dysfunctional visuomotor behaviors (a hallmark of executive function), and that all visual information processing, visuomotor planning, and movement execution may be affected.


Asunto(s)
Encéfalo/diagnóstico por imagen , CADASIL/diagnóstico por imagen , Disfunción Cognitiva/fisiopatología , Función Ejecutiva , Adulto , Encéfalo/fisiopatología , CADASIL/fisiopatología , CADASIL/psicología , Estudios de Casos y Controles , Corteza Cerebral/diagnóstico por imagen , Corteza Cerebral/fisiopatología , Cognición , Disfunción Cognitiva/psicología , Femenino , Lóbulo Frontal/diagnóstico por imagen , Lóbulo Frontal/fisiopatología , Neuroimagen Funcional , Giro del Cíngulo/diagnóstico por imagen , Giro del Cíngulo/fisiopatología , Humanos , Imagen por Resonancia Magnética/métodos , Masculino , Persona de Mediana Edad , Vías Nerviosas/diagnóstico por imagen , Vías Nerviosas/fisiopatología , Lóbulo Parietal/diagnóstico por imagen , Lóbulo Parietal/fisiopatología , Descanso , Corteza Visual/diagnóstico por imagen , Corteza Visual/fisiopatología
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