Your browser doesn't support javascript.
loading
Mostrar: 20 | 50 | 100
Resultados 1 - 20 de 4.501
Filtrar
1.
Chemosphere ; 286(Pt 3): 131844, 2022 Jan.
Artículo en Inglés | MEDLINE | ID: mdl-34392196

RESUMEN

The etiology of hypospadias and cryptorchidism, which are the two most common genital anomalies in males, has not been elucidated. Although prenatal exposure to endocrine-disrupting chemicals (EDCs) may increase the risks of hypospadias and cryptorchidism, the associations have not been confirmed. Therefore, we performed a meta-analysis to establish the relationships between prenatal exposure to EDCs and male genital anomalies. A systematic search of PubMed, EMbase, and Cochrane Library CENTRAL for relevant published studies providing quantitative data on the associations between prenatal EDCs exposure and hypospadias/cryptorchidism in humans was conducted. In total, sixteen case-controlled studies were included. Prenatal exposure to overall EDCs was associated with an increased risk of hypospadias in males (OR, 1.34, 95 % CI 1.12 to 1.60). Although there was no statistically significant association between overall EDCs exposure and cryptorchidism (OR, 1.11, 95 % CI 0.99 to 1.24), exposure to phenol substances was associated with an increased risk of cryptorchidism (OR, 1.81, 95 % CI, 1.12 to 2.93). Using the GRADE tool, we found the overall evidence to be of moderate certainty. In conclusion, the current evidence suggests prenatal EDCs exposure may increase the risk of hypospadias in males.


Asunto(s)
Criptorquidismo , Disruptores Endocrinos , Hipospadias , Estudios de Casos y Controles , Criptorquidismo/inducido químicamente , Criptorquidismo/epidemiología , Disruptores Endocrinos/toxicidad , Femenino , Genitales , Humanos , Hipospadias/inducido químicamente , Hipospadias/epidemiología , Masculino , Embarazo
2.
Chemosphere ; 287(Pt 1): 132046, 2022 Jan.
Artículo en Inglés | MEDLINE | ID: mdl-34474386

RESUMEN

Phthalate is an environmental endocrine disruptor that causes direct and intergenerational male reproductive damage. However, its mechanisms require further investigation. The role of gut microbiota in male reproductive function has been gradually revealed in the past. To explore the intergenerational testicular injury and the influence on offspring gut microbiota of the widely used phthalate dibutyl phthalate (DBP), we conducted a prenatal DBP exposure experiment with microbiota sequencing. We finally explained the gestational DBP exposure-induced gut dysbacteriosis, which is one of the mechanisms of testicular injury in the offspring. The occurrence of seminiferous atrophy and spermatogenic cells apoptosis showed a slight increase. Our study partially supported the results of previous research works on the characteristics of gut dysbacteriosis, which featured the increased relative abundance of Bacteroidetes, Prevotella and P. copri. Focusing on the role of gut microbiota in reproductive function is important. Future studies need to investigate the relationship between environmental pollution and human health.


Asunto(s)
Disruptores Endocrinos , Microbioma Gastrointestinal , Dibutil Ftalato/toxicidad , Disruptores Endocrinos/toxicidad , Femenino , Humanos , Masculino , Embarazo , Reproducción , Testículo
3.
Chemosphere ; 287(Pt 1): 132044, 2022 Jan.
Artículo en Inglés | MEDLINE | ID: mdl-34474391

RESUMEN

Bisphenol A (BPA) is a known endocrine disruptor and has been gradually replaced in industrial applications by other bisphenols, such as bisphenol S (BPS). However, whether these analogues are any safer for the central nervous system remains elusive. Here, we investigated behavioral impairments in mice after BPA and BPS exposure from postnatal days 21-49 (P21~P49). Results showed that BPA (0.1 and 1 mg/kg/d) and BPS (1 mg/kg/d) impaired emotion and social interaction of mice, while low dose exposure (0.1 mg/kg/d) induced no observable changes on emotion in mice. The behavioral deficits were accompanied by hyperactivation of the basolateral amygdala (BLA), i.e., dose-dependent increase in neuronal firing rates and local field potential power. In addition, glutamate receptors were up-regulated in the BLA, showing the same activation trend after exposure to different doses of BPA and BPS. Taken together, these findings imply that BPA and BPS cause behavioral impairments in juvenile mice by disrupting local neuronal activation in the BLA. Although BPS exerted less adverse effects on mice than BPA at the low dose, it does not appear to be a safe alternative to BPA in regard to brain function after prolonged high-volume exposure.


Asunto(s)
Complejo Nuclear Basolateral , Disruptores Endocrinos , Animales , Compuestos de Bencidrilo/toxicidad , Disruptores Endocrinos/toxicidad , Ratones , Neuronas , Fenoles
4.
Chemosphere ; 286(Pt 1): 131633, 2022 Jan.
Artículo en Inglés | MEDLINE | ID: mdl-34325267

RESUMEN

Endocrine-disrupting chemicals (EDCs) are widespread contaminants that severely affect the endocrine systems of living organisms. In addition to the conventional instrument-based approaches for quantifying organic pollutants, a monitoring method using transgenic plants has also been proposed. Plants carrying a recombinant receptor gene combined with a reporter gene represent a system for the easy detection of ligands that specifically bind to the receptor molecule. Here, the EDC detection sensitivity of transgenic Arabidopsis plants expressing the medaka (Oryzias latipes) estrogen receptor (mER) and green fluorescent protein (GFP) genes, was assessed. Four transgenic Arabidopsis lines, obtained by transformation with expression plasmids constructed using combinations of two types of the ligand-binding domains of mER, the DNA-binding domain of LexA and the transactivation domain of VP16 in the chimeric receptors, showed significant induction of GFP when germinated on a medium contaminated with 1 ng/mL 4-t-octylphenol (OP). The most sensitive XmEV19-2 plants detected 0.1 ng/mL OP and 1 pg/mL 17ß-estradiol. GFP expression was suppressed by the insecticides imidacloprid and fipronil, whereas perfluorooctanesulfonic acid induced it at 0.1 ng/mL. Experiments with river water-based medium showed that XmEV19-2 can be used for monitoring polluted waters, detecting OP at concentrations as low as 5 ng/mL. Notably, XmEV19-2 showed a significant decrease in root length when grown on 0.1 ng/mL OP. mER transgenic plants can be a promising tool for simple monitoring of EDCs, without the need for extraction and concentration steps in sample preparation.


Asunto(s)
Arabidopsis , Disruptores Endocrinos , Oryzias , Contaminantes Químicos del Agua , Animales , Arabidopsis/genética , Disruptores Endocrinos/análisis , Disruptores Endocrinos/toxicidad , Monitoreo del Ambiente , Oryzias/genética , Plantas Modificadas Genéticamente/genética , Receptores de Estrógenos/genética , Contaminantes Químicos del Agua/análisis , Contaminantes Químicos del Agua/toxicidad
5.
Chemosphere ; 286(Pt 1): 131639, 2022 Jan.
Artículo en Inglés | MEDLINE | ID: mdl-34346330

RESUMEN

Metals are one of the contaminants released from the increase of anthropic activities. They can be classified as endocrine disruptors once they can affect the reproductive parameters of different organisms. The aim of the study was to evaluate the potential effects of cadmium on regulatory reproduction axis (Hypothalamic-Pituitary-Gonadal-Liver, the HPGL axis) in females of Rhamdia quelen exposed to nominal concentrations of 0.1; 1; 10 and 100 µg.L-1 of cadmium. After 15 days, tissues were collected for hormonal quantification, brain aromatase (cyp19a1b), hepatic vitellogenin (vtg) gene expression, and biomarkers analysis. Cadmium was quantified in water, gonad and liver samples. The plasma levels of estradiol, testosterone and gonad and hepatosomatic indexes did not changed after Cd exposure. The cyp19a1b was not different among the groups. Cadmium was detected at higher concentrations in the liver compared to the gonads. No genotoxicity was observed, only erythrocytes nuclear alterations. Metallothionein was reduced at 10 µg.L-1 in the liver and 10 and 100 µg.L-1 in the gonad. Hepatic superoxide dismutase activity increased and this can lead to a hydrogen peroxide increase, one of reactive oxygen species. This increase without a compensation of other enzymes of the antioxidant system can lead to lipoperoxidation, as occurred at 100 µg.L-1. Hepatic vitellogenin gene expression increased as well as the injury index at 0,1 and 100 µg.L-1. The tested cadmium concentrations have been found in the freshwater ecosystems and can affect the female reproductive regulation axis HPGL of the Neotropical species R. quelen.


Asunto(s)
Disruptores Endocrinos , Contaminantes Químicos del Agua , Animales , Cadmio/toxicidad , Ecosistema , Disruptores Endocrinos/toxicidad , Femenino , Gónadas , Hígado , Reproducción , Vitelogeninas/genética , Contaminantes Químicos del Agua/toxicidad
6.
Rev Prat ; 71(7): 723-726, 2021 Sep.
Artículo en Francés | MEDLINE | ID: mdl-34792906

RESUMEN

ENDOCRINE DISRUPTORS: WHAT ARE WE TALKING ABOUT AND WHAT NEW MECHANISMS OF TOXICITY DO THEY BRING INTO PLAY? Endocrine disruptors (EDs) are chemicals that can interfere with the functioning of the endocrine system and thereby cause an adverse event. They are suspected of being toxic to the environment and to humans and to increase the risk of developing pathologies such as cancer, metabolic, neurological or immune diseases. These substances are defined by their mechanisms of action which are now described as "Adverse Outcome Pathways" or AOPs. AOPs correspond to a logical chain of events leading to an adverse effect. EDs have properties which have modified our concepts in toxicology, in particular due to the low-dose effects of certain EDs, the possible effects of ED mixtures and finally their delayed effects over time, sometimes with years or decades that separate exposure and impact. Epigenetic mechanisms probably explain these delayed effects.


Asunto(s)
Disruptores Endocrinos , Contaminantes Ambientales , Neoplasias , Disruptores Endocrinos/toxicidad , Epigénesis Genética , Humanos
7.
Rev Prat ; 71(7): 729-734, 2021 Sep.
Artículo en Francés | MEDLINE | ID: mdl-34792908

RESUMEN

WHAT IS KNOWN ABOUT THE ACTION OF ENDOCRINE DISRUPTORS ON THE IMMUNE SYSTEM? The immune system (innate and adaptive immunity), involves different tissues and cell types to defend the body against external aggressions. This physiological mechanism involves some hormonal systems for its proper functioning. Moreover, new relationships between the immune system and endocrine processes have been recently described. Immunotoxicology is therefore a rapidly expanding field of research. Many environmental pollutants, such as organochlorine pesticides, polycyclic aromatic hydrocarbons or heavy metals, have an impact on the immune response leading either to a deficiency or a hyperactivation (autoimmune disease, allergy). More recently, other endocrine disruptors such as organofluorines are suspected to be immunotoxic. Low-level exposure to pollutants in the general population probably does not explain the development of all the pathologies, but it sentisizes organisms to the development of these pathologies, weakening certain key processes of the immune system.


Asunto(s)
Disruptores Endocrinos , Contaminantes Ambientales , Hipersensibilidad , Hidrocarburos Policíclicos Aromáticos , Disruptores Endocrinos/toxicidad , Contaminantes Ambientales/toxicidad , Humanos , Sistema Inmunológico/química , Hidrocarburos Policíclicos Aromáticos/análisis , Hidrocarburos Policíclicos Aromáticos/toxicidad
8.
Rev Prat ; 71(7): 735-739, 2021 Sep.
Artículo en Francés | MEDLINE | ID: mdl-34792909

RESUMEN

WHAT ABOUT THE EFFECTS OF ENDOCRINE DISRUPTORS ON NEURODEVELOPMENT? Development of the central nervous system (CNS) relies on many endogenous factors. Thyroid hormones and sex steroid hormones are among the most studied endocrine systems for their regulation of neural functions, since early embryonic stages of development. Environmental exposure to low doses of chemicals is largely documented. The hypothesis that exposure to some of these molecules with endocrine disrupting activity, likely interfering with the production of these hormones and/or their underlying neural mechanisms is therefore plausible and supported by numerous studies. After having recalled the formation of the hypothalamo-hypophyseal axes, and the importance of thyroid and sexual hormones in neurodevelopment, we will present two examples of substances (BPA, PCBs) and their effects on brain development.


Asunto(s)
Disruptores Endocrinos , Disruptores Endocrinos/toxicidad , Exposición a Riesgos Ambientales/efectos adversos
9.
Rev Prat ; 71(7): 740-746, 2021 Sep.
Artículo en Francés | MEDLINE | ID: mdl-34792910

RESUMEN

WHAT DO WE KNOW ABOUT EFFECTS OF THE ENDOCRINE DISRUPTORS ON METABOLISM AND OBESITY? Some endocrine disruptors (EDs) are suspected to be involved in the increase of the prevalence of obesity and metabolic diseases. Data from epidemiological, in vivo, in vitro and in silico studies suggest that EDs may exert their effects on numerous tissues involved in energy metabolism and in the regulation of appetite: adipose tissue, liver, muscle, pancreas, gut and hypothalamus. Their effects are due to: disruptions of the carbohydrate and lipid homeostasis in these organs, via the activation of specific nuclear receptors or transcriptional factors, disturbances in communication between these organs, and epigenetic mechanisms, involved for example in intergenerational effects. The characterization of the effects of EDs on endocrine systems is still under investigations in several European and international projects and initiatives, with the aim to establish new validated regulatory tests for ED identification.


Asunto(s)
Disruptores Endocrinos , Disruptores Endocrinos/toxicidad , Humanos , Hipotálamo , Obesidad/inducido químicamente , Obesidad/epidemiología
11.
Artículo en Chino | MEDLINE | ID: mdl-34624962

RESUMEN

Endocrine disrupting chemicals (EDCs) are a kind of exogenous chemicals widely existing in the environment, which cause serious harm to the environment and human health. At present, the impact of this type of substance on the thyroid has attracted much attention.This review summarized the effects of EDCs on thyroid hormones, and phosphatidylinositol 3-kinase (PI3K) /protein kinase B (Akt) /mammalian target of rapamycin (mTOR) (PI3K/Akt/mTOR) signaling pathway and its role in thyroid diseases, and explore the role of PI3K/Akt/mTOR signaling pathway in EDCs-induced apoptosis and autophagy of thyroid follicular epithelial cells.This paper could provide further understandings for thyroid diseases induced by the autophagy and apoptosis of thyroid follicular epithelial cells.


Asunto(s)
Disruptores Endocrinos , Células Epiteliales Tiroideas , Apoptosis , Autofagia , Disruptores Endocrinos/toxicidad , Humanos , Fosfatidilinositol 3-Quinasa/metabolismo , Fosfatidilinositol 3-Quinasas/metabolismo , Proteínas Proto-Oncogénicas c-akt/metabolismo , Transducción de Señal , Serina-Treonina Quinasas TOR/metabolismo , Células Epiteliales Tiroideas/metabolismo
12.
Nutrients ; 13(10)2021 Oct 17.
Artículo en Inglés | MEDLINE | ID: mdl-34684636

RESUMEN

Gestational high butterfat (HFB) and/or endocrine disruptor exposure was previously found to disrupt spermatogenesis in adulthood. This study addresses the data gap in our knowledge regarding transgenerational transmission of the disruptive interaction between a high-fat diet and endocrine disruptor bisphenol A (BPA). F0 generation Sprague-Dawley rats were fed diets containing butterfat (10 kcal%) and high in butterfat (39 kcal%, HFB) with or without BPA (25 µg/kg body weight/day) during mating and pregnancy. Gestationally exposed F1-generation offspring from different litters were mated to produce F2 offspring, and similarly, F2-generation animals produced F3-generation offspring. One group of F3 male offspring was administered either testosterone plus estradiol-17ß (T + E2) or sham via capsule implants from postnatal days 70 to 210. Another group was naturally aged to 18 months. Combination diets of HFB + BPA in F0 dams, but not single exposure to either, disrupted spermatogenesis in F3-generation adult males in both the T + E2-implanted group and the naturally aged group. CYP19A1 localization to the acrosome and estrogen receptor beta (ERbeta) localization to the nucleus were associated with impaired spermatogenesis. Finally, expression of methyl-CpG-binding domain-3 (MBD3) was consistently decreased in the HFB and HFB + BPA exposed F1 and F3 testes, suggesting an epigenetic component to this inheritance. However, the severe atrophy within testes present in F1 males was absent in F3 males. In conclusion, the HFB + BPA group demonstrated transgenerational inheritance of the impaired spermatogenesis phenotype, but severity was reduced in the F3 generation.


Asunto(s)
Compuestos de Bencidrilo/toxicidad , Mantequilla , Grasas de la Dieta/efectos adversos , Infertilidad Masculina/inducido químicamente , Exposición Materna/efectos adversos , Fenoles/toxicidad , Efectos Tardíos de la Exposición Prenatal/inducido químicamente , Espermatogénesis/efectos de los fármacos , Animales , Dieta Alta en Grasa/efectos adversos , Modelos Animales de Enfermedad , Disruptores Endocrinos/toxicidad , Epigénesis Genética , Estradiol , Femenino , Infertilidad Masculina/genética , Patrón de Herencia , Masculino , Fenómenos Fisiologicos Nutricionales Maternos , Embarazo , Efectos Tardíos de la Exposición Prenatal/genética , Ratas , Ratas Sprague-Dawley , Espermatogénesis/genética , Testículo/metabolismo
13.
Artículo en Inglés | MEDLINE | ID: mdl-34639339

RESUMEN

This study investigated the binding abilities of extracellular polymers produced by an environmentally isolated strain of Enterococcus hirae towards phytoestrogen endocrine disruptors-biochanin A, formonetin, genistein and daidzein. The extracellular biopolymer exhibited notable binding and removal for all four phytoestrogens, with a maximum removal of daidzein (87%) followed by genistein (72%) at a 1-1.5 mg/mL concentration. Adsorption proceeded rapidly at ambient temperature. The adsorption data fitted well with the Langmuir isotherm. Based on the adsorption energy, the biopolymer binding of phytoestrogens was inferred as daidzein > genistein > biochanin A > formononetin. Toxicity of the biopolymer (5-250 µg/mL) evaluated using RAW 264.7 cell lines indicated no significant (p < 0.05) changes in viability. In biopolymer-challenged Caenorhabditis elegans previously exposed to daidzein, complete protection to developmental toxicity, such as reduced egg-laying capacity, egg viability and progeny counts of the worm, was observed. The results of this study offer valuable insights into understanding the potential role of microbial extracellular biopolymers in binding and removal of phytoestrogens with sustainable technological implications in modulating the toxic effect of high levels of endocrine disruptors in the environment.


Asunto(s)
Disruptores Endocrinos , Isoflavonas , Animales , Caenorhabditis elegans , Disruptores Endocrinos/toxicidad , Genisteína/toxicidad , Fitoestrógenos/toxicidad , Polímeros , Agua
14.
Horm Metab Res ; 53(9): 575-587, 2021 Sep.
Artículo en Inglés | MEDLINE | ID: mdl-34496408

RESUMEN

Global warming and the rising prevalence of obesity are well described challenges of current mankind. Most recently, the COVID-19 pandemic arose as a new challenge. We here attempt to delineate their relationship with each other from our perspective. Global greenhouse gas emissions from the burning of fossil fuels have exponentially increased since 1950. The main contributors to such greenhouse gas emissions are manufacturing and construction, transport, residential, commercial, agriculture, and land use change and forestry, combined with an increasing global population growth from 1 billion in 1800 to 7.8 billion in 2020 along with rising obesity rates since the 1980s. The current Covid-19 pandemic has caused some decline in greenhouse gas emissions by limiting mobility globally via repetitive lockdowns. Following multiple lockdowns, there was further increase in obesity in wealthier populations, malnutrition from hunger in poor populations and death from severe infection with Covid-19 and its virus variants. There is a bidirectional relationship between adiposity and global warming. With rising atmospheric air temperatures, people typically will have less adaptive thermogenesis and become less physically active, while they are producing a higher carbon footprint. To reduce obesity rates, one should be willing to learn more about the environmental impact, how to minimize consumption of energy generating carbon dioxide and other greenhouse gas emissions, and to reduce food waste. Diets lower in meat such as a Mediterranean diet, have been estimated to reduce greenhouse gas emissions by 72%, land use by 58%, and energy consumption by 52%.


Asunto(s)
Cambio Climático , Obesidad/etiología , Agricultura/economía , Agricultura/tendencias , COVID-19/complicaciones , COVID-19/epidemiología , COVID-19/patología , Cambio Climático/historia , Comorbilidad , Disruptores Endocrinos/toxicidad , Ambiente , Exposición a Riesgos Ambientales/historia , Exposición a Riesgos Ambientales/estadística & datos numéricos , Gases de Efecto Invernadero/toxicidad , Historia del Siglo XIX , Historia del Siglo XX , Historia del Siglo XXI , Humanos , Obesidad/epidemiología , Obesidad/metabolismo , Pandemias , Factores de Riesgo
15.
Aquat Toxicol ; 239: 105953, 2021 Oct.
Artículo en Inglés | MEDLINE | ID: mdl-34521059

RESUMEN

The molecular mode of action underpinning the response of mollusks exposure to endocrine disrupting chemicals (EDCs) remains unclear due to a lack of available information regarding their genome. Single molecule real-time (SMRT) sequencing makes it possible to reveal molecular mechanisms by direct sequencing of full-length transcripts. In the present study, the transcriptome profile of the freshwater snail Parafossarulus striatulus after exposure to 17ß-estradiol (E2) or 17α-methyltestosterone (MT) was evaluated using SMRT sequencing strategy. In total, 216,598 non-redundant and full-length gene isoforms were generated and 106,266 isoforms were predicted with a complete open reading frame (ORF). Moreover, 60.36% of the isoforms were matched to known proteins in at least one of six databases. Differential gene expression analyses showed significantly different patterns in paired samples with different treatments. The expression levels of several membrane receptor isoforms of P. striatulus including dopamine receptor (DR), FMRFamide receptor (FMRFaR), neuropeptide Y receptor (NYR) and neuropeptide FF receptor (NFFR), but not estrogen receptor (ER) or estrogen-related receptor (ERR), were significantly affected by E2 and MT. These findings suggest that activation of membrane receptors, as well as other signaling pathways, might be critical for mediating the effects of endocrine disruption in mollusks. The transcriptome information obtained from the SMRT sequencing provides a significant contribution to the investigation of the molecular mode of action of endocrine disrupting chemicals on P. striatulus.


Asunto(s)
Disruptores Endocrinos , Contaminantes Químicos del Agua , Andrógenos , Disruptores Endocrinos/toxicidad , Estrógenos/toxicidad , Agua Dulce , Contaminantes Químicos del Agua/toxicidad
16.
J Agric Food Chem ; 69(38): 11427-11439, 2021 Sep 29.
Artículo en Inglés | MEDLINE | ID: mdl-34524809

RESUMEN

Endocrine-active chemicals can directly act on nuclear receptors and trigger the disturbances of metabolism and a homeostatic system, which are important risk factors for complicating chronic diseases in humans. The endocrine-active potentials of pesticides acting on estrogen, androgen, and thyroid hormone receptors have been extensively evaluated for pesticides; however, the effects on other receptors are less understood. This study aims to comprehensively characterize and prioritize the endocrine-active pesticides using an exposure-activity ratio (EAR) method and toxicological prioritization index (ToxPi). The aggregate exposure assessment of pesticides was performed using a computational exposure model [stochastic human exposure and dose simulation high-throughput model (SHEDS-HT)]. Minimum in vitro point of departure values were converted to human oral equivalent doses via in vitro-to-in vivo extrapolation. The overall endocrine-disrupting potentials of pesticides were evaluated via 76 assays, representing 11 nuclear receptors. EARs and ToxPi scores were then derived to prioritize 79 pesticides in food. This case study demonstrates that EAR profiling can inform the regulatory agencies for a relevant chemical prioritization, which would direct in-depth health risk assessments in the future.


Asunto(s)
Disruptores Endocrinos , Plaguicidas , Productos Agrícolas , Disruptores Endocrinos/toxicidad , Sistema Endocrino , Ensayos Analíticos de Alto Rendimiento , Humanos , Plaguicidas/toxicidad , Medición de Riesgo
17.
Artículo en Inglés | MEDLINE | ID: mdl-34587401

RESUMEN

Tetrabromobisphenol A (TBBPA) is a brominated flame retardant that is used in a variety of consumer products such as electronic equipment, fire extinguishers, furniture, plastics, textiles, and kitchen hoods. Most studies show that the TBBPA production process and TBBPA in industrial and urban sewage waste result in extensive human exposure and environmental contamination. TBBPA can accumulate in organisms, particularly aquatic life, and is classified as a group 2A carcinogen (likely carcinogenic to humans) by the International Agency for Research on Cancer. This compound produces low acute toxicity, but chronic exposure may produce serious consequences. In this review, we focus on TBBPA toxicity by discussing results of various studies that were published in the last two decades. Studies show that TBBPA acts as an endocrine disruptor, causing neurobehavioral and immunotoxic effects, oxidative stress, and apoptosis. Although several experiments were performed in vitro and in vivo, human data are lacking, and thus, chronic toxic effects of TBBPA on humans are not well known, particularly in sensitive populations including pregnant women, newborns, children, and the elderly. Epidemiological studies that comprehensively assess TBBPA levels in biological fluids of different populations and in different pathological conditions are needed. Research on the impact of TBBPA, particularly regarding endocrine disorders and cancer, must also be performed.


Asunto(s)
Disruptores Endocrinos/toxicidad , Síndromes de Neurotoxicidad/etiología , Bifenilos Polibrominados/toxicidad , Animales , Organismos Acuáticos/efectos de los fármacos , Disruptores Endocrinos/farmacocinética , Exposición a Riesgos Ambientales/efectos adversos , Femenino , Humanos , Masculino , Estrés Oxidativo/efectos de los fármacos , Bifenilos Polibrominados/farmacocinética , Embarazo
18.
Ecotoxicol Environ Saf ; 225: 112758, 2021 Dec 01.
Artículo en Inglés | MEDLINE | ID: mdl-34507038

RESUMEN

Endocrine-disrupting chemicals (EDCs) in the effluent from wastewater treatment plants (WWTPs) are an important pollutant sources of the aquatic system. In this study, the removal efficiencies of eight typical EDCs at two domestic WWTPs in Dongguan City, China, are reported based on instrumental analysis and bioassay results. Bioactivities, including steroidogenesis-disrupting effects, estrogen receptor (ER)-binding activity, and aryl hydrocarbon receptor (AhR)-binding activity were evaluated using the H295R, MVLN, and H4IIE cell bioassays, respectively. The potential environmental risks of these residual EDCs were also evaluated. The results of instrumental analysis showed that nonylphenol was the major chemical type present among the eight tested EDCs. Meanwhile, concentrations of estrogen compounds including estrone, 17ß-estradiol (E2), estriol, 17α-ethinyl estradiol, and diethylstilbestrol were relatively low. The removal rates of all eight EDCs were relatively high. Although the chemical analysis indicated high removal efficiency, the bioassay results showed that steroidogenesis-disrupting effects as well as ER-binding and AhR-binding activities remained, with E2-equivalent values of effluent samples ranging from 0.16 to 0.9 ng·L-1, and 2,3,7,8-tetrachlorodibenzo-p-dioxin-equivalent values ranging from 0.61 to 4.09 ng L-1. Principal component analysis combined with regression analysis suggests that the chemicals analyzed in this study were partly responsible for these ER and AhR activities. Ecological risk assessment of the residual EDCs showed that estrone was the most hazardous chemical among the eight EDCs tested, with a risk quotient of 1.44-5.50. Overall, this study suggests that, despite high apparent removal efficiencies of typical EDCs, their bioactivities and potential ecological risks cannot be ignored.


Asunto(s)
Disruptores Endocrinos , Contaminantes Químicos del Agua , Purificación del Agua , Disruptores Endocrinos/análisis , Disruptores Endocrinos/toxicidad , Monitoreo del Ambiente , Medición de Riesgo , Eliminación de Residuos Líquidos , Contaminantes Químicos del Agua/análisis , Contaminantes Químicos del Agua/toxicidad
19.
Int J Mol Sci ; 22(17)2021 Aug 27.
Artículo en Inglés | MEDLINE | ID: mdl-34502222

RESUMEN

Although the use of bisphenol A (BPA) has been banned in a number of countries, its presence in the environment still creates health issues both for humans and wildlife. So far, BPA toxicity has been largely investigated on different biological processes, from reproduction to development, immune system, and metabolism. In zebrafish, Danio rerio, previous studies revealed the ability of environmentally relevant concentrations of this contaminant to significantly impair fertility via epigenetic modification. In addition, several studies demonstrated the ability of different probiotic strains to improve organism health. This study provides information on the role of the probiotic mixture SLAb51 to counteract adverse BPA effects on reproduction. A 28-day trial was set up with different experimental groups: BPA, exposed to 10 µg/L BPA; P, receiving a dietary supplementation of SLAb51 at a final concentration of 109 CFU/g; BPA+P exposed to 10 µg/L BPA and receiving SLAb51 at a final concentration of 109 CFU/g and a C group. Since oocyte growth and maturation represent key aspects for fertility in females, studies were performed on isolated class III (vitellogenic) and IV (in maturation) follicles and liver, with emphasis on the modulation of the different vitellogenin isoforms. In males, key signals regulating spermatogenesis were investigated. Results demonstrated that in fish exposed to the combination of BPA and probiotic, most of the transcripts were closer to C or P levels, supporting the hypothesis of SLAb51 to antagonize BPA toxicity. This study represents the first evidence related to the use of SLAb51 to improve reproduction and open new fields of investigation regarding its use to reduce endocrine disrupting compound impacts on health.


Asunto(s)
Compuestos de Bencidrilo/toxicidad , Fenoles/toxicidad , Probióticos/farmacología , Reproducción , Espermatogénesis , Pez Cebra/fisiología , Animales , Disruptores Endocrinos/toxicidad , Depuradores de Radicales Libres/toxicidad
20.
Int J Mol Sci ; 22(18)2021 Sep 20.
Artículo en Inglés | MEDLINE | ID: mdl-34576301

RESUMEN

Organochlorine pesticides, such as DDT, methoxychlor, and their metabolites, have been characterized as endocrine disrupting chemicals (EDCs); suggesting that their modes of action involve interaction with or abrogation of endogenous endocrine function. This study examined whether embryonic thymocyte death and alteration of differentiation induced by the primary metabolite of methoxychlor, HPTE, rely upon estrogen receptor binding and concurrent T cell receptor signaling. Estrogen receptor inhibition of ERα or GPER did not rescue embryonic thymocyte death induced by HPTE or the model estrogen diethylstilbestrol (DES). Moreover, adverse effects induced by HPTE or DES were worsened by concurrent TCR and CD2 differentiation signaling, compared with EDC exposure post-signaling. Together, these data suggest that HPTE- and DES-induced adverse effects on embryonic thymocytes do not rely solely on ER alpha or GPER but may require both. These results also provide evidence of a potential collaborative signaling mechanism between TCR and estrogen receptors to mediate adverse effects on embryonic thymocytes, as well as highlight a window of sensitivity that modulates EDC exposure severity.


Asunto(s)
Diferenciación Celular , Disruptores Endocrinos/toxicidad , Receptor alfa de Estrógeno/metabolismo , Fenoles/toxicidad , Receptores de Estrógenos/metabolismo , Receptores Acoplados a Proteínas G/metabolismo , Timocitos/efectos de los fármacos , Animales , Antígenos CD2/metabolismo , Muerte Celular , Células Cultivadas , Receptor alfa de Estrógeno/antagonistas & inhibidores , Femenino , Masculino , Ratones , Ratones Endogámicos C57BL , Receptores de Antígenos de Linfocitos T/metabolismo , Receptores de Estrógenos/antagonistas & inhibidores , Receptores Acoplados a Proteínas G/antagonistas & inhibidores , Transducción de Señal , Timocitos/citología , Timocitos/metabolismo
SELECCIÓN DE REFERENCIAS
DETALLE DE LA BÚSQUEDA
...