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1.
Bioresour Technol ; 331: 125030, 2021 Jul.
Artículo en Inglés | MEDLINE | ID: mdl-33823486

RESUMEN

Maintaining high current densities is a key challenge in scaling-up microbial electrolysis cell (MEC) reactors. In this study, a novel 10 L MEC reactor with a total electrode surface area greater than 1 m2 was designed and evaluated to maximize the current density and H2 recovery. Performances of the reactor suggest that the longitudinal structure with parallel vertical orientation of the electrodes encouraged high fluid mixing and the sheet metal electrode frames provided distributed electrical connection. Results also demonstrated that the electrode pairs located next to reactor walls decreased current density, as did separating the electrodes with separators. High volumetric H2 production rate of 5.9 L/L/d was achieved at a volumetric current density of 970 A/m3 (34 A/m2). Moreover, the observed current densities of the large reactor were accurately predicted based on the internal resistance analysis of small scale MECs (0.15 L), demonstrating the scalability of the single chamber MEC design.


Asunto(s)
Fuentes de Energía Bioeléctrica , Electricidad , Electrodos , Electrólisis , Hidrógeno
2.
Water Sci Technol ; 83(7): 1677-1690, 2021 Apr.
Artículo en Inglés | MEDLINE | ID: mdl-33843751

RESUMEN

Electrochemical water softening has been widely used in industrial circulating cooling water systems; however, their low deposition efficiency is the main drawback that limits usage in medium to large enterprises. In this work, the effect of different parameters on the hardness removal efficiency and energy consumption of the electrochemical water softening system is experimentally studied, and the performance of water softening applied by high frequency electric fields and direct current electric fields are comparative analyzed. The impact factors of the electrochemical water softening system are as follows: initial feed concentration of solute, magnitude of voltage, inter-electrode distance, area of cathode and frequency of power supply. To improve the analysis efficiency, the L25 (55) orthogonal table is used to investigate the five different factors at five levels. The experimental results are shown that the initial feed concentration of solute is the most significant factor affecting the hardness removal efficiency. The optimal combination for water softening in the group applied by high frequency electric field and direct current electric field are A3B2C1D4E3 and A2B5C3D1 respectively. The energy utilization of the device applied by high frequency electric field is 3.2 times that applied by direct current electric field. The practice shows that direct current electric fields have a better softening effect, and are is more suitable for scaling ion removal. Particle image velocimetry (PIV) was used to observe the flow field induced by the electrolysis and found that the vertical and horizontal velocities of the flow field at low voltage are conducive to the migration of scaled ions to the cathode, and then the electrolytic reaction and deposition reaction synergy effect is the optimal.


Asunto(s)
Electricidad , Ablandamiento del Agua , Electrodos , Iones
3.
Sheng Wu Yi Xue Gong Cheng Xue Za Zhi ; 38(2): 361-368, 2021 Apr 25.
Artículo en Chino | MEDLINE | ID: mdl-33913297

RESUMEN

In order to solve the current problems in medical equipment maintenance, this study proposed an intelligent fault diagnosis method for medical equipment based on long short term memory network(LSTM). Firstly, in the case of no circuit drawings and unknown circuit board signal direction, the symptom phenomenon and port electrical signal of 7 different fault categories were collected, and the feature coding, normalization, fusion and screening were preprocessed. Then, the intelligent fault diagnosis model was built based on LSTM, and the fused and screened multi-modal features were used to carry out the fault diagnosis classification and identification experiment. The results were compared with those using port electrical signal, symptom phenomenon and the fusion of the two types. In addition, the fault diagnosis algorithm was compared with BP neural network (BPNN), recurrent neural network (RNN) and convolution neural network (CNN). The results show that based on the fused and screened multi-modal features, the average classification accuracy of LSTM algorithm model reaches 0.970 9, which is higher than that of using port electrical signal alone, symptom phenomenon alone or the fusion of the two types. It also has higher accuracy than BPNN, RNN and CNN, which provides a relatively feasible new idea for intelligent fault diagnosis of similar equipment.


Asunto(s)
Memoria a Corto Plazo , Redes Neurales de la Computación , Algoritmos , Electricidad
4.
Bioresour Technol ; 332: 125077, 2021 Jul.
Artículo en Inglés | MEDLINE | ID: mdl-33823475

RESUMEN

The microbial nutrient recovery cell i.e. modified microbial fuel cell containing a middle recovery chamber can be used to purify wastewater and remove valuable nutrients, while simultaneously generating electricity. The study investigated nutrient removal and microorganism interactions with carbon (CB- HT and CB- APTES) and stainless steel (SSB-HT) modified anodes used in microbial nutrient recovery cells. The removal efficiencies of ammonium ions were found higher in carbon-based CB-APTES (~98%) and CB-HT (~98.27%) systems in comparison to SSB-HT (~87.16%) system. On comparing further, the removal efficiencies of chemical oxygen demand (~99.5%) and total phosphorus (~99%) in CB- APTES system were superior to the cases of CB- HT, and SSB- HT systems. Besides, the CB-APTES based microbial fuel cell (MFC) displayed an average stable voltage of 0.5 V and a maximum power density of ~ 850 mW/m2.


Asunto(s)
Fuentes de Energía Bioeléctrica , Electricidad , Electrodos , Nutrientes , Aguas Residuales
5.
Bioresour Technol ; 332: 125088, 2021 Jul.
Artículo en Inglés | MEDLINE | ID: mdl-33839511

RESUMEN

This study evaluated the effect of bioaugmentation of a newly enriched electroactive bacterial community DC5 on the performance of a pilot scale sequential two-step Horizontal Sub-surface flow Constructed Wetland-Microbial Fuel Cell (HSCW-MFC) system treating textile dye wastewater. The system consisted of CW-MFC-1 planted with Fimbristylis ferruginea and CW-MFC-2 planted with consortium of Fimbristylis ferruginea and Elymus repens plant species. Before bioaugmentation, HSCW-MFC system showed 62 ± 2% Chemical Oxygen Demand (COD) and 90 ± 1.5% American Dye Manufacturer's Institute (ADMI) removal and 177.3 mW/m2 maximum power density (CW-MFC-1). After bioaugmentation of DC5 into the HSCW-MFC, COD and ADMI removal was enhanced to 74.10 ± 1.75% and 97.32 ± 1.90% with maximum power density of 197.94 mW/m2 (CW-MFC-1). The genera Exiguobacterium, Desulfovibrio and Macellibacteroides of DC5 were significantly enriched at the electrodes of HSCW-MFC after bioaugmentation. These results demonstrate that the performance of the CW-MFC treating textile dye wastewater can be improved by bioaugmentation of electroactive bacterial community.


Asunto(s)
Fuentes de Energía Bioeléctrica , Electricidad , Electrodos , Textiles , Aguas Residuales , Humedales
6.
Huan Jing Ke Xue ; 42(5): 2378-2384, 2021 May 08.
Artículo en Chino | MEDLINE | ID: mdl-33884808

RESUMEN

Large amounts of wastewater containing residual antibiotics are produced in antibiotics production, but it is difficult for traditional biological wastewater treatment to efficiently treat this high concentration antibiotic wastewater. Coupled electrocatalytic and bioelectrochemical systems were proposed to treat typical ß-lactam antibiotics (penicillin) wastewater. The penicillin wastewater was oxidized by a boron-doped diamond (BDD) electrocatalytic electrode and then steadily treated by a bioelectrochemical system (BES). The penicillin removal rate of the electrocatalytic system was 89%, and 79% of the residual penicillin was further removed by the BES. The maximum power density of the BES with pretreated penicillin of (1124±28) mW·m-2 was increased by 473% compared with that of the BES with raw penicillin. The total penicillin removal rate was 98% in the electrocatalytic and bioelectrochemical system. The results of the BES anode biomass and biofacies showed that Acinetobacter was the dominant bacterial group on the anode before penicillin addition, and it was the main microorganism in the formation of the anode biofilm. Bacillus is an electricity-producing bacterium with a power generation function. Penicillin inhibited the biomass of the mixed anode bacteria and the biological activity of Proteus microorganisms, which were the main electricity-producing bacteria, and reduced the biomass of Acinetobacter and Bacillus. This was the main factor affecting the power generation performance and reactor treatment effect. The pretreatment of penicillin wastewater by electrocatalytic degradation can significantly decrease its concentration, efficiently alleviate the inhibition of the BES by penicillin, and improve the biodegradability of wastewater. The coupled electrocatalytic and bioelectrochemical system is a new technology for antibiotic wastewater treatment with a high efficiency and low energy consumption.


Asunto(s)
Fuentes de Energía Bioeléctrica , Purificación del Agua , Electricidad , Electrodos , Penicilinas , Aguas Residuales
7.
Sensors (Basel) ; 21(6)2021 Mar 10.
Artículo en Inglés | MEDLINE | ID: mdl-33801797

RESUMEN

An electrically small patch antenna with a low-cost high-permittivity ceramic substrate material for use in a ground-penetrating radar is proposed in this work. The antenna is based on a commercial ceramic 915 MHz patch antenna with a size of 25 × 25 × 4 mm3 and a weight of 12.9 g. The influences of the main geometric parameters on the antenna's electromagnetic characteristics were comprehensively studied. Three bandwidth improvement techniques were sequentially applied to optimize the antenna: tuning the key geometric parameters, adding cuts on the edges, and adding parasitic radiators. The designed antenna operates at around 1.3 GHz and has more than 40 MHz continuous -3 dB bandwidth. In comparison to the original antenna, the -3 and -6 dB fractional bandwidth is improved by 1.8 times and 4 times, respectively. Two antennas of the proposed design together with a customized radar were installed on an unmanned aerial vehicle (UAV) for a quick search for survivors after earthquakes or gas explosions without exposing the rescue staff to the uncertain dangers of moving on the debris.


Asunto(s)
Fenómenos Electromagnéticos , Radar , Electricidad , Humanos , Respiración
8.
Sensors (Basel) ; 21(9)2021 Apr 25.
Artículo en Inglés | MEDLINE | ID: mdl-33923046

RESUMEN

As the number of single-person households grows worldwide, the need to monitor their safety is gradually increasing. Among several approaches developed previously, analyzing the daily lifelog data generated unwittingly, such as electricity consumption or communication usage, has been discussed. However, data analysis methods in the domain are currently based on anomaly detection. This presents accuracy issues and the challenge of securing service reliability. We propose a new analysis method that finds activities such as operation or movement from electricity consumption and communication usage data. This is evidence of safety. As a result, we demonstrate better performance through comparative verification. Ultimately, this study aims to contribute to a more reliable implementation of a service that enables monitoring of lonely deaths.


Asunto(s)
Comunicación , Electricidad , Humanos , Reproducibilidad de los Resultados
9.
Sensors (Basel) ; 21(9)2021 Apr 26.
Artículo en Inglés | MEDLINE | ID: mdl-33925825

RESUMEN

C-reactive protein (CRP) is an acute-phase reactive protein that appears in the bloodstream in response to inflammatory cytokines such as interleukin-6 produced by adipocytes and macrophages during the acute phase of the inflammatory/infectious process. CRP measurement is widely used as a representative acute and chronic inflammatory disease marker. With the development of diagnostic techniques measuring CRP more precisely than before, CRP is being used not only as a traditional biomarker but also as a biomarker for various diseases. The existing commercialized CRP assays are dominated by enzyme-linked immunosorbent assay (ELISA). ELISA has high selectivity and sensitivity, but its limitations include requiring complex analytic processes, long analysis times, and professional manpower. To overcome these problems, nanobiotechnology is able to provide alternative diagnostic tools. By introducing the nanobio hybrid material to the CRP biosensors, CRP can be measured more quickly and accurately, and highly sensitive biosensors can be used as portable devices. In this review, we discuss the recent advancements in electrochemical, electricity, and spectroscopy-based CRP biosensors composed of biomaterial and nanomaterial hybrids.


Asunto(s)
Técnicas Biosensibles , Proteína C-Reactiva , Biomarcadores , Electricidad , Técnicas Electroquímicas
10.
J Environ Manage ; 286: 112259, 2021 May 15.
Artículo en Inglés | MEDLINE | ID: mdl-33677340

RESUMEN

Electricity demand in megacities may exert substantial stress on water resources, which is often expressed through the water scarcity footprint for electricity consumption (WSFE). Conversely, water scarcity may constrain electricity production, leading to increased vulnerability for megacities electricity production. The WSFE and the water related vulnerability of electricity production reflect two aspects of water-electricity conflict. This varies over time by both the amount and location of electricity production. However, no studies have conducted time-series analysis to evaluate the trends of these two indicators, both in terms of severity and spatial characteristics. Our study focused on evaluating trends in water-electricity conflict both within and beyond megacity administrative boundaries. China's four provincial-level megacities, i.e. Beijing, Tianjin, Shanghai and Chongqing, were chosen as case studies. The results show that water related vulnerability of electricity production in Tianjin, Beijing, Shanghai and Chongqing was diverse and can be classified as extreme, severe, moderate and minor, respectively. Between 2006 and 2016, the WSFE of Tianjin experienced an increasing trend, and its water related vulnerability of electricity production remained at the highest level. Beijing's WSFE has decreased, but its water related vulnerability of electricity production has increased. These differing trends highlight the need for joint reductions to both WSFE and water related vulnerability of electricity production in mitigating water-electricity conflict.


Asunto(s)
Abastecimiento de Agua , Agua , Beijing , China , Electricidad
11.
J Environ Manage ; 287: 112261, 2021 Jun 01.
Artículo en Inglés | MEDLINE | ID: mdl-33721760

RESUMEN

This research evaluates the impacts of the Renewable Portfolio Standard (RPS) on renewable electricity capacity using annual data spanning 47 states between 1990 and 2014 in the United States. RPS is a state-level policy that requires electricity suppliers to include a certain fraction of renewable electricity in their total electricity sales over a specified time period. Following nuanced identification strategies, generalized difference-in-difference method is used to transform observational data into a quasiexperimental setting to mitigate against potentially inconsistent estimator or selection bias concerns vis-à-vis the adoption of RPS across states. Generalized least squares with panel corrected standard errors and spatial econometric methods are selected as estimation techniques. The results show that RPS adoption drives more than one third increase in overall renewable electricity capacity. RPS impacts on total electricity capacity remain significantly positive with consistent estimates across modeling scenarios. However, the results reveal that impacts of heterogeneous RPS attributes differ across competing sources of renewable electricity. The impacts are positively significant for solar and wind capacity with the largest impact on wind capacity, while they are insignificant or significantly negative for biomass and geothermal capacity. The significantly positive contribution of renewable energy certificates provision and manifestation of spatial spillover effects indicate the regional marketing possibilities of renewable energy. The results imply that scaling up RPS proliferation across the states and specifying RPS targets by renewable energy sources at least up to the point when renewable energy sector achieves efficiency gains (economies of scales and allocative efficiency) or better alternatives to the RPS become available (e.g., least-cost carbon pricing policy), can play critical roles to exert transformative advances in renewable electricity sector.


Asunto(s)
Energía Renovable , Viento , Biomasa , Electricidad , Estándares de Referencia , Estados Unidos
12.
J Environ Manage ; 287: 112319, 2021 Jun 01.
Artículo en Inglés | MEDLINE | ID: mdl-33721763

RESUMEN

The theoretical energy density extractable from acidic and alkaline solutions is higher than 20 kWh m-3 of single solution when mixing 1 M concentrated streams. Therefore, acidic and alkaline industrial wastewater have a huge potential for the recovery of energy. To this purpose, bipolar membrane reverse electrodialysis (BMRED) is an interesting, yet poorly studied technology for the conversion of the mixing entropy of solutions at different pH into electricity. Although it shows promising performance, only few works have been presented in the literature so far, and no comprehensive models have been developed yet. This work presents a mathematical multi-scale model based on a semi-empirical approach. The model was validated against experimental data and was applied over a variety of operating conditions, showing that it may represent an effective tool for the prediction of the BMRED performance. A sensitivity analysis was performed in two different scenarios, i.e. (i) a reference case and (ii) an improved case with high-performance membrane properties. A Net Power Density of ~15 W m-2 was predicted in the reference scenario with 1 M HCl and NaOH solutions, but it increased significantly by simulating high-performance membranes. A simulated scheme for an industrial application yielded an energy density of ~50 kWh m-3 (of acid solution) with an energy efficiency of ~80-90% in the improved scenario.


Asunto(s)
Membranas Artificiales , Aguas Residuales , Electricidad , Fuerza Protón-Motriz , Ríos
13.
Waste Manag ; 125: 1-9, 2021 Apr 15.
Artículo en Inglés | MEDLINE | ID: mdl-33667978

RESUMEN

The European Union is promoting the uptake of low emission vehicles to reduce greenhouse gas emissions from transportation. However, this transition will increase the demand for five important battery raw materials; i.e. lithium, nickel, cobalt, copper, and graphite. Therefore, a substance flow analysis and forecasting model are proposed to investigate the flow of these materials through the different lifecycle stages of electric vehicle batteries. The model forecasts that by 2040, the vehicle stock will be from 72 to 78 million vehicles, while the second use stock will be from 3 to 11 million batteries. In addition, the annual recycling waste stream in 2040 will grow to roughly 3 million batteries with a capacity of 125 GWh. Results indicate that this waste stream could cover between 10% and 300% of future raw materials demand for electric vehicles. The width of this range is dominated by uncertainties on the rapidly evolving material composition of automotive batteries and the possible commercialization of cobalt-free battery technologies. The remaining uncertainty is attributed to the battery lifetime in vehicle use and potential second use of retired batteries.


Asunto(s)
Suministros de Energía Eléctrica , Litio , Electricidad , Europa (Continente) , Reciclaje
14.
Waste Manag ; 125: 27-39, 2021 Apr 15.
Artículo en Inglés | MEDLINE | ID: mdl-33667980

RESUMEN

The main aim of this study was to assess the suitability of geophysical methods for investigating old waste dumps. Electrical Resistivity Tomography (ERT), Seismic Refraction Tomography (SRT), Multichannel Analysis of Surface Waves (MASW) and Ground Penetrating Radar (GPR) were the techniques used to characterize a waste dump in the town of Dabrowa Górnicza (S Poland). GPR and SRT were the most difficult methods to use because of the dense vegetation, which attenuated the passage of electromagnetic and seismic waves to the ground. However, GPR did turn out to be an appropriate tool for characterizing variations in the surface cover. ERT, SRT and MASW clearly highlighted the transition between the waste deposit and the host sediments, and determined the approximate thickness of the waste deposits. With MASW, however, the waste type and the boundary between the waste layer and surface cover could not be delineated. In some places, the surface cover was identified using SRT. With both these methods, the problem with identification may be due to the small contrast in the S- and P-wave velocities through two kinds of waste (municipal and industrial), the thinness of the waste layer, and the considerable differentiation of the surface cover. The most accurate results regarding the waste deposits were obtained using ERT and different electrode spacings. ERT pinpointed the exact location of the stored waste, distinguished between the types of waste, and identified the soil cover. Data from shallow boreholes confirmed the interpretations of the methods.


Asunto(s)
Monitoreo del Ambiente , Instalaciones de Eliminación de Residuos , Electricidad , Polonia , Tomografía
15.
Molecules ; 26(5)2021 Feb 26.
Artículo en Inglés | MEDLINE | ID: mdl-33652943

RESUMEN

An implicit account of the solvent effect can be carried out using traditional static quantum chemistry calculations by applying an external electric field to the studied molecular system. This approach allows one to distinguish between the effects of the macroscopic reaction field of the solvent and specific solute-solvent interactions. In this study, we report on the dependence of the simulation results on the use of the polarizable continuum approximation and on the importance of the solvent effect in nonpolar solvents. The latter was demonstrated using experimental data on tautomeric equilibria between the pyridone and hydroxypyridine forms of 2,6-di-tert-butyl-4-hydroxy-pyridine in cyclohexane and chloroform.


Asunto(s)
Ciclohexanos/química , Metales Alcalinos/química , Piridinas/química , Solventes/química , Cloroformo , Simulación por Computador , Electricidad , Modelos Moleculares , Teoría Cuántica , Soluciones/química , Termodinámica
16.
Bioresour Technol ; 330: 125012, 2021 Jun.
Artículo en Inglés | MEDLINE | ID: mdl-33773265

RESUMEN

Sugarcane is an important cash crop used for producing sweeteners and also some bioproducts (alcohol and bioenergy). The current study assesses life cycle energy, carbon and water footprint of sugarcane based sugar, ethanol and electricity in India. A farm to factory gate attributional life cycle assessment (LCA) is conducted to assess the energy and carbon footprints whereas the Food and Agriculture Organization's (FAO) CropWat model is used to estimate the water footprint (green, blue and grey). For the base case, electricity has the highest energy return on investment (EROI), lowest carbon and water footprints among the bioproducts. The choice of allocation method (economic, mass, and energy) impacts the energy and environmental outcomes of the bioproducts. The comparison among four different sugarcane seasons shows that bioproducts available from Adsali sugarcane have the highest EROI, lowest carbon and water footprints. The findings could lead to improved sustainability of sugarcane bioproducts in India.


Asunto(s)
Huella de Carbono , Saccharum , Animales , Carbono , Electricidad , Etanol , India , Estadios del Ciclo de Vida , Azúcares , Agua
17.
Bioresour Technol ; 330: 124999, 2021 Jun.
Artículo en Inglés | MEDLINE | ID: mdl-33780712

RESUMEN

The energy potential of residue-derived biogas via electricity and biomethane production was assessed in an integrated 1G2G sugarcane biorefinery concept. The mono-digestion of 1G-vinasse (1G-VN) was compared with different co-digestion systems, namely, 1G-VN + filter cake (FC) + deacetylation liquor (DL) in the season and FC + DL in the off-season. Gross energy output values and the resulting sugarcane use efficiency were also assessed in different biorefinery schemes. Electricity production from 1G to VN (5.0 MW) could be increased by over 400% through its co-digestion with FC and DL (22.3 MW). Alternatively, biomethane could fully supply the diesel-powered fleet (1.8 × 106 Nm3 month-1) of a sugarcane plant processing 10 million tons of sugarcane per harvest, and the surplus biogas could flexibly provide 36 MW of extra electricity. Biomethane could enhance the energy output of 1G2G sugarcane biorefineries by 15%. However, 2G processes still require marked improvements to maximize energy production from sugarcane.


Asunto(s)
Saccharum , Anaerobiosis , Biocombustibles , Digestión , Electricidad , Metano
18.
Sensors (Basel) ; 21(4)2021 Feb 11.
Artículo en Inglés | MEDLINE | ID: mdl-33670122

RESUMEN

Microbial electrochemical systems are a fast emerging technology that use microorganisms to harvest the chemical energy from bioorganic materials to produce electrical power. Due to their flexibility and the wide variety of materials that can be used as a source, these devices show promise for applications in many fields including energy, environment and sensing. Microbial electrochemical systems rely on the integration of microbial cells, bioelectrochemistry, material science and electrochemical technologies to achieve effective conversion of the chemical energy stored in organic materials into electrical power. Therefore, the interaction between microorganisms and electrodes and their operation at physiological important potentials are critical for their development. This article provides an overview of the principles and applications of microbial electrochemical systems, their development status and potential for implementation in the biosensing field. It also provides a discussion of the recent developments in the selection of electrode materials to improve electron transfer using nanomaterials along with challenges for achieving practical implementation, and examples of applications in the biosensing field.


Asunto(s)
Fuentes de Energía Bioeléctrica , Técnicas Biosensibles , Nanoestructuras , Electricidad , Electrodos , Transporte de Electrón
19.
Sensors (Basel) ; 21(4)2021 Feb 18.
Artículo en Inglés | MEDLINE | ID: mdl-33670691

RESUMEN

The development of biomedical devices benefits patients by offering real-time healthcare. In particular, pacemakers have gained a great deal of attention because they offer opportunities for monitoring the patient's vitals and biological statics in real time. One of the important factors in realizing real-time body-centric sensing is to establish a robust wireless communication link among the medical devices. In this paper, radio transmission and the optimal characteristics for impedance matching the medical telemetry of an implant are investigated. For radio transmission, an integral coupling formula based on 3D vector far-field patterns was firstly applied to compute the antenna coupling between two antennas placed inside and outside of the body. The formula provides the capability for computing the antenna coupling in the near-field and far-field region. In order to include the effects of human implantation, the far-field pattern was characterized taking into account a sphere enclosing an antenna made of human tissue. Furthermore, the characteristics of impedance matching inside the human body were studied by means of inherent wave impedances of electrical and magnetic dipoles. Here, we demonstrate that the implantation of a magnetic dipole is advantageous because it provides similar impedance characteristics to those of the human body.


Asunto(s)
Prótesis e Implantes , Telemetría , Impedancia Eléctrica , Electricidad , Humanos
20.
Int J Mol Sci ; 22(5)2021 Feb 25.
Artículo en Inglés | MEDLINE | ID: mdl-33668791

RESUMEN

Interactions between phospholipid membranes and selected drugs affecting the central nervous system (CNS) were investigated. Small, unilamellar liposomes were used as biomimetic cell membrane models. Microelectrophoretic experiments on two-component liposomes were performed using the electrophoretic light scattering technique (ELS). The effect of both positively (perphenazine, PF) and negatively (barbituric acid, BA) charged drugs on zwitterionic L-α-phosphatidylcholine (PC) membranes were analyzed. Experimental membrane surface charge density (δ) data were determined as a function of pH. Quantitative descriptions of the adsorption equilibria formed due to the binding of solution ions to analyzed two-component membranes are presented. Binding constants of the solution ions with perphenazine and barbituric acid-modified membranes were determined. The results of our research show that both charged drugs change surface charge density values of phosphatidylcholine membranes. It can be concluded that perphenazine and barbituric acid are located near the membrane surface, interacting electrostatically with phosphatidylcholine polar heads.


Asunto(s)
Barbitúricos/farmacología , Sistema Nervioso Central/fisiología , Electricidad , Perfenazina/farmacología , Fosfatidilcolinas/metabolismo , Animales , Aniones , Cationes , Sistema Nervioso Central/efectos de los fármacos , Pollos , Punto Isoeléctrico , Liposomas , Membranas Artificiales , Modelos Biológicos , Dispersión de Radiación , Soluciones , Electricidad Estática
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