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1.
Lancet ; 395(10221): 335, 2020 02 01.
Artículo en Inglés | MEDLINE | ID: mdl-32007161
2.
Lancet ; 395(10221): 335-336, 2020 02 01.
Artículo en Inglés | MEDLINE | ID: mdl-32007162
3.
Oral Health Prev Dent ; 18(1): 77-83, 2020.
Artículo en Inglés | MEDLINE | ID: mdl-32051974

RESUMEN

PURPOSE: The aim of this study was to evaluate the association between periodontitis and preterm birth in a Spanish Caucasian population, based on clinical and biochemical outcomes. Epidemiological studies have suggested that periodontitis is a potential risk factor for preterm birth. However, other studies have shown high heterogeneity in their results. Some factors such as number of evaluations during pregnancy, sample size, study population and maternal age may have an impact on the variability of the result. METHODS AND MATERIALS: This cohort study enrolled 158 pregnant women, 39 with periodontitis and 119 without periodontitis. All pregnant women were evaluated in the first, second and third trimester. RESULTS: Statistically significant differences were found in periodontal parameters between both groups, but no statistically significant differences were found in biochemical parameters during pregnancy. The duration of pregnancy in healthy patients was 38.78 ± 4.49 weeks, and in patients with periodontitis 37.81 ± 4.89 weeks, with no statistical difference (p > 0.05). This showed that periodontitis was not associated with preterm birth in a Spanish Caucasian cohort. CONCLUSION: In this study, periodontitis stage II, grade B, was not statistically associated with preterm birth. Pregnancy is a short period of time in order to evaluate long-term oral systemic infections. Adverse pregnancy outcomes are more difficult to occur. Thus, since pregnancy timing average cannot be changed, the stages of periodontal disease (initial, moderate, advanced) could be another factor to study.


Asunto(s)
Periodontitis , Nacimiento Prematuro , Estudios de Cohortes , Femenino , Humanos , Recién Nacido de Bajo Peso , Recién Nacido , Embarazo , Resultado del Embarazo , Factores de Riesgo
6.
Rev Med Liege ; 75(2): 105-110, 2020 Feb.
Artículo en Francés | MEDLINE | ID: mdl-32030935

RESUMEN

Late preterm infants are born between 34 weeks of amenorrhea and 36 weeks 6 days. Late preterms represent the largest proportion of premature infants (about 75 %). Late prematurity is increasing in recent decades. While studies initially focused on mortality and morbidity related to very preterm birth, the late preterms have been the subject of increased attention over the past 15 years. Late preterm infants have an increased risk of respiratory complications, infections, feeding problems, hypothermia and hypoglycemia. Neonatal, infant and during adulthood mortalities are significantly higher in late preterm than in term infants. In addition, late preterm infants carry an increased risk of long-term morbidities, such as neurodevelopmental delay, cerebral palsy, chronic respiratory or metabolic diseases. This review highlights the evidence that late preterm infants are high risk newborns and require adapted follow-up.


Asunto(s)
Enfermedades del Prematuro , Recien Nacido Prematuro , Nacimiento Prematuro , Adulto , Femenino , Edad Gestacional , Humanos , Lactante , Recién Nacido , Morbilidad , Embarazo
7.
Rev Med Liege ; 75(2): 111-114, 2020 Feb.
Artículo en Francés | MEDLINE | ID: mdl-32030936

RESUMEN

The use of hormone therapy is an important therapeutic choice in woman's life, both for contraceptive purpose to avoid unwanted pregnancy, as well as for treatment of menstrual disorders, or climacteric symptoms. Medical care must therefore be dynamic, tailored to individual requirements as much as possible, reflecting personal and family background, potential risks related to treatment, and of course patient's wishes. We will first discuss the modalities of contraception in presence of obesity, then the need for potential adjustment following bariatric surgery.


Asunto(s)
Cirugía Bariátrica , Anticoncepción , Obesidad , Femenino , Humanos , Obesidad/cirugía , Embarazo
8.
Adv Neurobiol ; 24: 143-162, 2020.
Artículo en Inglés | MEDLINE | ID: mdl-32006359

RESUMEN

Autism spectrum disorder (ASD) is a rapidly growing global pandemic that affects an estimated 1 in 59-68 children. It is a complex disease with both genetic and environmental etiologies. Due to the rapid increase in the incidence of ASD, environmental causes for ASD are gaining attention. Efforts to probe several environmental exposures that could contribute to causing ASD are underway. In this regard, this chapter is directed towards understanding prenatal exposure to key environmental factors i.e., drugs and dietary nutrients that may act via the same molecular pathway - epigenetics as a potential etiological factor for ASD. Epigenetic regulation is a molecular mechanism known to be a significant contributor to neurodevelopmental disorders. It also offers a means to explain how environmental exposures can impact genetics. We discuss the impact of maternal exposures to certain drugs, and dietary intake, on the developing fetus during pregnancy. Maternal Exposure to some drugs during gestation are associated with a higher risk of ASD, while exposure to other dietary compounds may offer promise to rescue epigenetic regulatory insults related to ASD. However, more work in this important area is still required, nevertheless preliminary research already has important implications in the understanding, prevention and treatment of ASD.


Asunto(s)
Trastorno del Espectro Autista/inducido químicamente , Trastorno del Espectro Autista/genética , Dieta/efectos adversos , Epigénesis Genética/efectos de los fármacos , Exposición Materna/efectos adversos , Efectos Tardíos de la Exposición Prenatal/inducido químicamente , Efectos Tardíos de la Exposición Prenatal/genética , Trastorno del Espectro Autista/prevención & control , Trastorno del Espectro Autista/terapia , Femenino , Humanos , Recién Nacido , Embarazo
9.
Adv Exp Med Biol ; 1191: 523-541, 2020.
Artículo en Inglés | MEDLINE | ID: mdl-32002944

RESUMEN

Exposure therapy, a key treatment for anxiety disorders, can be modelled in the laboratory using Pavlovian fear extinction. Understanding the hormonal and neurobiological mechanisms underlying fear extinction in females, who are twice more likely than males to present with anxiety disorders, may aid in optimising exposure therapy outcomes in this population. This chapter will begin by discussing the role of the sex hormones, estradiol and progesterone, in fear extinction in females. We will also propose potential mechanisms by which these hormones may modulate fear extinction. The second half of this chapter will discuss the long-term hormonal, neurological and behavioural changes that arise from pregnancy and motherhood and how these changes may alter the features of fear extinction in females. Finally, we will discuss implications of this research for the treatment of anxiety disorders in women with and without prior reproductive experience.


Asunto(s)
Trastornos de Ansiedad/metabolismo , Trastornos de Ansiedad/terapia , Ansiedad/metabolismo , Ansiedad/terapia , Estradiol/metabolismo , Progesterona/metabolismo , Reproducción , Ansiedad/psicología , Trastornos de Ansiedad/psicología , Extinción Psicológica , Miedo , Femenino , Humanos , Embarazo
10.
Lancet ; 395(10221): e17, 2020 02 01.
Artículo en Inglés | MEDLINE | ID: mdl-32007174
11.
MMWR Morb Mortal Wkly Rep ; 69(5): 133-135, 2020 Feb 07.
Artículo en Inglés | MEDLINE | ID: mdl-32027627

RESUMEN

At its October 2019 meeting, the Advisory Committee on Immunization Practices (ACIP)* voted to recommend approval of the 2020 Recommended U.S. Adult Immunization Schedule for Persons Aged 19 Years and Older. The 2020 adult immunization schedule, available at https://www.cdc.gov/vaccines/schedules/index.html,† summarizes ACIP recommendations in two tables and accompanying notes. This 2020 adult immunization schedule has been approved by the CDC Director, the American College of Physicians, the American Academy of Family Physicians, the American College of Obstetricians and Gynecologists, and the American College of Nurse-Midwives. Health care providers are advised to use the tables and the notes together.


Asunto(s)
Esquemas de Inmunización , Inmunización/normas , Vacunas/administración & dosificación , Adulto , Comités Consultivos , Femenino , Humanos , Masculino , Embarazo , Estados Unidos
18.
Zhongguo Dang Dai Er Ke Za Zhi ; 22(2): 87-90, 2020 Feb.
Artículo en Chino | MEDLINE | ID: mdl-32051071

RESUMEN

Since December 2019, the novel coronavirus (2019-nCoV) infection has been prevalent in China. Due to immaturity of immune function and the possibility of mother-fetal vertical transmission, neonates are particularly susceptible to 2019-nCoV. The perinatal-neonatal departments should cooperate closely and take integrated approaches, and the neonatal intensive care unit should prepare the emergency plan for 2019-nCoV infection as far as possible, so as to ensure the optimal management and treatment of potential victims. According to the latest 2019-nCoV national management plan and the actual situation, the Working Group for the Prevention and Control of Neonatal 2019-nCoV Infection in the Perinatal Period of the Editorial Committee of Chinese Journal of Contemporary Pediatrics puts forward recommendations for the prevention and control of 2019-nCoV infection in neonates.


Asunto(s)
Infecciones por Coronavirus , Niño , China , Femenino , Humanos , Recién Nacido , Transmisión Vertical de Enfermedad Infecciosa , Unidades de Cuidado Intensivo Neonatal , Embarazo
19.
Zhongguo Dang Dai Er Ke Za Zhi ; 22(2): 146-151, 2020 Feb.
Artículo en Chino | MEDLINE | ID: mdl-32051082

RESUMEN

OBJECTIVE: To study the predictive factors for poor prognosis of neonates with early-onset sepsis (EOS). METHODS: The clinical data of 371 neonates with EOS were collected. According to prognosis, they were divided into a good prognosis group with 264 neonates and a poor prognosis group with 107 neonates. The two groups were compared in terms of perinatal conditions, clinical manifestations, laboratory markers, comorbidities, and treatment process. Multivariate logistic regression analysis was used to investigate the predictive factors for poor prognosis of EOS. RESULTS: The poor prognosis group had significantly lower birth weight and gestational age than the good prognosis group (P<0.05). Compared with the good prognosis group, the poor prognosis group had significantly higher proportions of preterm neonates, low birth weight neonates, very low birth weight neonates and twins (P<0.05), as well as a significantly higher proportion of mothers who used hormone or antibiotics before delivery (P<0.05). Compared with the good prognosis group, the poor prognosis group had significantly higher incidence rates of poor response and respiratory hypofunction (P<0.05) and a significantly lower incidence rate of jaundice (P<0.05). Compared with the good prognosis group, the poor prognosis group had significantly higher incidence rates of white blood cell count <5×109/L, platelet count <100×109/L, anemia, coagulation disorder, renal dysfunction, liver impairment, hypoproteinemia, and hypoglycemia (P<0.05). The poor prognosis group had significantly higher incidence rates of neonatal respiratory distress syndrome, pulmonary hemorrhage, necrotizing enterocolitis, intraventricular hemorrhage, brain injury, pulmonary hypertension, and shock than the good prognosis group (P<0.05). Compared with the good prognosis group, the poor prognosis group had significantly longer length of hospital stay and course of treatment with antibiotics (P<0.05) and a significantly higher proportion of neonates receiving mechanical ventilation or vasoactive agents (P<0.05). The multivariate logistic regression analysis showed that very low birth weight (OR=41.734), necrotizing enterocolitis (OR=12.669), brain injury (OR=8.372), shock (OR=5.889), mechanical ventilation (OR=5.456), and liver impairment (OR=4.075) were independent predictive factors for poor prognosis of neonates with EOS (P<0.05). CONCLUSIONS: Very low birth weight, mechanical ventilation, necrotizing enterocolitis, brain injury, shock, and liver impairment have a certain value in predicting the poor prognosis of neonates with EOS.


Asunto(s)
Sepsis , Peso al Nacer , Femenino , Edad Gestacional , Humanos , Recién Nacido , Embarazo , Pronóstico , Factores de Riesgo
20.
Medicine (Baltimore) ; 99(5): e18731, 2020 Jan.
Artículo en Inglés | MEDLINE | ID: mdl-32000376

RESUMEN

Miscarriage is the spontaneous loss of a clinically established intrauterine pregnancy before the fetus has reached viability. In order to compare the performance of traditional G banding karyotyping with next-generation sequencing (NGS) for detecting common trisomies in products of conception (POC). Chromosome abnormalities were detected by high-resolution G banding karyotyping and NGS. A total of 48 miscarriage samples, including 20 samples without karyotype result and 28 with karyotype results were selected and coded for analysis by NGS. The multiplex PCR analysis of maternal and miscarriage DNA for single nucleotide polymorphism (SNP) markers were used to simultaneously monitor maternal cell contamination (MCC), chromosomal status, and sex of the miscarriage tissue. NGS detection results of 21 chromosome abnormalities were consisted with that in karyotyping examination. These chromosome abnormalities samples included 9 chromosome 16 trisomies, 3 chromosome 22 trisomies, 2 chromosome 7 trisomies, 2 chromosome 18 trisomies, 1 chromosome 4 trisomies, one chromosome 10 trisomies, 1 chromosome 13 trisomies, 1 chromosome 15 trisomies and 1 sex chromosomal aneuploidies (45, X). Meanwhile, NGS analysis of seven chromosome normalities was adapted to the karyotyping examination. Therefore, NGS combined with multiplex PCR is an effective method to test trisomies in POC. The results mentioned above will contribute to a detailed understanding of the first-trimester spontaneous miscarriages.


Asunto(s)
Secuenciación de Nucleótidos de Alto Rendimiento/estadística & datos numéricos , Trisomía/diagnóstico , Aborto Espontáneo/genética , Femenino , Humanos , Embarazo
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