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1.
Braz. j. biol ; 84: e257074, 2024. tab, graf, ilus
Artículo en Inglés | LILACS, VETINDEX | ID: biblio-1360211

RESUMEN

The study of biologically active substances-secondary metabolites of plants that exhibit geroprotective properties is an actual and popular direction in medicine to prevent early aging. This work aims to select the cultivation parameters for obtaining in vitro cell cultures of meadowsweet containing the largest amount of biologically active substances (BAS) for their further extraction as candidate substances for geroprotectors. To specify the effectiveness of the selected cell culture cultivation parameters, biomass growth for callus and root cultures, growth index, specific growth rate, and viability for suspension cultures was carried out. The study results made it possible to select the nutrient media for the cultivation of cell cultures of meadowsweet. It has been found that the greater the antioxidant activity of the extracts, the greater the antimicrobial properties it exhibits. In this study, cell cultures in vitro and alcohol extracts from the plant Filipendula ulmaria were considered as raw materials rich in candidate substances for geroprotectors. According to the data obtained, the plant is rich in hydroxybenzoic and salicylic acids, spireoside, avicularin, and hyperoside.


O estudo de substâncias biologicamente ativas - metabólitos secundários de plantas que apresentam propriedades geroprotetoras - é uma tendência atual e popular no campo da medicina para a prevenção do envelhecimento precoce. O objetivo deste trabalho foi selecionar os parâmetros de cultivo para obtenção de culturas celulares in vitro de Ulmária contendo a maior quantidade de substâncias biologicamente ativas (SBA), para sua posterior extração como substâncias candidatas a serem geroprotetoras. Para especificar a eficácia dos parâmetros selecionados de cultivo em cultura de células, foi realizada a análise de crescimento de biomassa para culturas de calos e raízes, índice de crescimento, taxa de crescimento específica e viabilidade para culturas em suspensão. Os resultados do estudo possibilitaram a seleção do meio nutriente para o cultivo de células de Ulmária. Verificou-se que, quanto maior a atividade antioxidante dos extratos, maiores eram as propriedades antimicrobianas exibidas. Neste estudo, culturas celulares in vitro e extratos alcoólicos da planta Filipendula ulmaria foram considerados matérias-primas ricas em substâncias candidatas a serem geroprotetoras. De acordo com os dados obtidos, a planta é rica em ácidos hidroxibenzoico e salicílico, espirosídeo, avicularina e hiperosídeo.


Asunto(s)
Plantas Medicinales/genética , Envejecimiento , Envejecimiento Prematuro , Antioxidantes
2.
J Hazard Mater ; 441: 129831, 2023 01 05.
Artículo en Inglés | MEDLINE | ID: mdl-36084457

RESUMEN

The contagious coronavirus disease-2019 pandemic has led to an increasing number of disposable face masks (DFMs) abandoned in the environment, when they are exposed to the air condition, the broken of chemical bond induced aging is inevitably occurred which meantime would cause a drastic decrease of the mechanical flexibility. However, the understanding of between chemical bond change related to aging and its micromechanical loss is limited due to the lack of refined techniques. Herein, the atomic force microscopy (AFM) technique was firstly used to observe the aging process induced by methine of the polypropylene-based DFMs. By comparing the micromechanical properties loss, the influences of humidity and light density on the DFM aging were systematically studied in the early 72 h, and it revealed that the increasing scissions number of the easiest attacked methine (Ct-H) can gradually decrease the micromechanical properties of the polypropylene (PP)-based DFM. Furthermore, the results are also validated by the in- situ FTIR and XPS analysis. This work discloses that an aging process can be initially estimated with the micromechanical changes observed by AFM, which offers fundamental data to manage this important emerging plastic pollution during COVID-19 pandemic.


Asunto(s)
COVID-19 , Polipropilenos , Envejecimiento , COVID-19/prevención & control , Humanos , Máscaras , Microscopía de Fuerza Atómica , Pandemias
3.
Methods Mol Biol ; 2562: 135-154, 2023.
Artículo en Inglés | MEDLINE | ID: mdl-36272072

RESUMEN

Cellular senescence is a permanent proliferation arrest mechanism induced following the detection of genotoxic stress. Mounting evidence has causally linked the accumulation of senescent cells to a growing number of age-related pathologies in mammals. However, recent data have also highlighted senescent cells as important mediators of tissue remodeling during organismal development, tissue repair, and regeneration. As powerful model organisms for studying such processes, salamanders constitute a system in which to probe the characteristics, physiological functions, and evolutionary facets of cellular senescence. In this chapter, we outline methods for the generation, identification, and characterization of salamander senescent cells in vitro and in vivo.


Asunto(s)
Senescencia Celular , Urodelos , Animales , Senescencia Celular/fisiología , Daño del ADN , Cicatrización de Heridas/fisiología , Envejecimiento/fisiología , Mamíferos
4.
Arch Gerontol Geriatr ; 104: 104820, 2023 Jan.
Artículo en Inglés | MEDLINE | ID: mdl-36108360

RESUMEN

INTRODUCTION: The aim of this paper is to demonstrate how graphical chain models can be used to model how cardiovascular disease affected quality of life in later life over the course of 17 years of data. METHODS: Waves 1-9 of the English Longitudinal Study of Ageing was used to investigate how quality of life changed over each wave using the CASP-19 questionnaire, and whether having experienced a cardiovascular event had an effect on quality of life. RESULTS: A total of 12,099 participants were included in the study. Participants had a mean age of 64.2 years, the majority of which were over 50 years old. Older people are more likely to have cardiac events. A one-unit rise in CES-D 8-item score was related with a 14% increased risk of CVD at Wave 1. Those with an O-level, A-level, or degree (or equivalent) had lower CVD risks than those with no education. Women had half the CVD risk of men. Living alone reduced the risk of a CVD-event by 15%. Moderate and vigorous exercise lowered cardiac event risk compared to no exercise. Current or ex-smokers have a 30% higher risk of CVD than non-smokers. Cardiovascular event was significantly associated with quality of life at waves 1 and 2 only. DISCUSSION: Events related to cardiovascular disease only affected quality of life in later life up to 4 years. Factors such as age, depression, perceived position on social ladder, and high levels of physical activity affected quality of life throughout the majority of waves.


Asunto(s)
Enfermedades Cardiovasculares , Calidad de Vida , Anciano , Femenino , Humanos , Masculino , Envejecimiento , Enfermedades Cardiovasculares/epidemiología , Ejercicio Físico , Estudios Longitudinales , Factores de Riesgo , Persona de Mediana Edad , Escolaridad , Fumar/efectos adversos
5.
Gen Comp Endocrinol ; 330: 114126, 2023 Jan 01.
Artículo en Inglés | MEDLINE | ID: mdl-36122793

RESUMEN

Alzheimer's disease (AD) is a progressive, dementing, whole-body disorder that presents with decline in cognitive, behavioral, and emotional functions, as well as endocrine dysregulation. The etiology of AD is not fully understood but stress- and anxiety-related hormones may play a role in its development and trajectory. The glucocorticoid cascade hypothesis posits that levels of glucocorticoids increase with age, leading to dysregulated negative feedback, further elevated glucocorticoids, and resulting neuropathology. We examined the impact of age (from 2 to 10 months) and stressor exposure (predator odor) on hormone levels (corticosterone and ghrelin), anxiety-like behavior (open field and light dark tests), and memory-related behavior (novel object recognition; NOR), and whether these various measures correlated with neuropathology (hippocampus and cortex amyloid beta, Aß) in male and female APPswe/PS1dE9 transgenic and non-transgenic mice. Additionally, we performed exploratory analyses to probe if the open field and light dark test as commonly used tasks to assess anxiety levels were correlated. Consistent with the glucocorticoid cascade hypothesis, baseline corticosterone increased with age. Predator odor exposure elevated corticosterone at each age, but in contrast to the glucocorticoid cascade hypothesis, the magnitude of stressor-induced elevations in corticosterone levels did not increase with age. Overall, transgenic mice had higher post-stressor, but not baseline, corticosterone than non-transgenic mice, and across both genotypes, females consistently had higher (baseline and post-stressor) corticosterone than males. Behavior in the open field test primarily showed decreased locomotion with age, and this was pronounced in transgenic females. Anxiety-like behaviors in the light dark test were exacerbated following predator odor, and female transgenic mice were the most impacted. Compared to transgenic males, transgenic females had higher Aß concentrations and showed more anxiety-like behavior. Performance on the NOR did not differ significantly between genotypes. Lastly, we did not find robust, statistically significant correlations among corticosterone, ghrelin, recognition memory, anxiety-like behaviors, or Aß, suggesting outcomes are not strongly related on the individual level. Our data suggest that despite Aß accumulation in the hippocampus and cortex, male and female APPswePS1dE9 transgenic mice do not differ robustly from their non-transgenic littermates in physiological, endocrine, and behavioral measures at the range of ages studied here.


Asunto(s)
Enfermedad de Alzheimer , Glucocorticoides , Ratones , Masculino , Femenino , Animales , Corticosterona , Ghrelina , Péptidos beta-Amiloides/metabolismo , Sistema Hipófiso-Suprarrenal/metabolismo , Sistema Hipotálamo-Hipofisario/metabolismo , Ansiedad , Enfermedad de Alzheimer/genética , Enfermedad de Alzheimer/psicología , Ratones Transgénicos , Envejecimiento/fisiología , Estrés Psicológico
6.
J Affect Disord ; 320: 436-441, 2023 Jan 01.
Artículo en Inglés | MEDLINE | ID: mdl-36202300

RESUMEN

BACKGROUND: Evidence suggests that depression may be a risk factor for dementia in older adults, but the link between depressive symptoms and brain health earlier in life is less understood. Our aim was to investigate the association between long-term depressive symptoms in young to mid-adulthood and a measure of brain age derived from structural MRI. METHODS: From the Coronary Artery Risk Development in Young Adults study, we identified 649 participants (age 23-36 at baseline) with brain MRI and cognitive testing. Long-term depressive symptoms were measured with the Center for Epidemiological Studies Depression scale (CESD) six times across 25 years and analyzed as time-weighted averages (TWA). Brain age was derived using previously validated high dimensional neuroimaging pattern analysis, quantifying individual differences in age-related atrophy. Elevated depressive symptoms were defined as CES-D ≥16. Linear regression was used to test the association between TWA depressive symptoms, brain aging, and cognition. RESULTS: Each standard deviation (5-points) increment in TWA depression symptoms over 25 years was associated with one-year greater brain age (ß: 1.14, 95 % confidence interval [CI]: 0.57 to 1.71). Participants with elevated TWA depressive symptoms had on average a 3-year greater brain age (ß: 2.75, 95 % CI: 0.43 to 5.08). Moreover, elevated depressive symptoms were associated with higher odds of poor cognitive function in midlife (OR: 3.30, 95 % CI: 1.37 to 7.97). LIMITATIONS: Brain age was assessed at one time, limiting our ability to evaluate the temporality of depressive symptoms and brain aging. CONCLUSIONS: Elevated depressive symptoms in early adulthood may have implications for brain health as early as in midlife.


Asunto(s)
Encéfalo , Depresión , Humanos , Anciano , Adulto , Adulto Joven , Depresión/diagnóstico , Encéfalo/diagnóstico por imagen , Envejecimiento/psicología , Cognición , Pruebas Neuropsicológicas , Estudios Longitudinales
7.
Clin Geriatr Med ; 39(1): 123-134, 2023 Feb.
Artículo en Inglés | MEDLINE | ID: mdl-36404025

RESUMEN

One of the most challenging clinical expressions of population aging is cognitive impairment and dementia. Among risk factors for the development of dementia, modifiable vascular risk factors have emerged as contributors to both vascular and nonvascular types of dementia. Epidemiologic studies have been particularly informative in understanding the link between vascular risks and dementia across the life course. We discuss vascular risks for dementia and cognitive impairment and practical management recommendations.


Asunto(s)
Disfunción Cognitiva , Demencia , Humanos , Demencia/epidemiología , Demencia/etiología , Demencia/prevención & control , Disfunción Cognitiva/epidemiología , Disfunción Cognitiva/etiología , Disfunción Cognitiva/prevención & control , Factores de Riesgo , Envejecimiento
8.
Clin Geriatr Med ; 39(1): 151-160, 2023 Feb.
Artículo en Inglés | MEDLINE | ID: mdl-36404028

RESUMEN

In the absence of effective treatments for dementia, maintaining cognitive health in old age is one of the major challenges facing aging societies. Interventions for cognitive health that are tailored to the person are more likely to bring the best benefits with a minimum burden. We review the existing literature on this topic and discuss the role of the primary care physician.


Asunto(s)
Disfunción Cognitiva , Reserva Cognitiva , Demencia , Humanos , Reserva Cognitiva/fisiología , Longevidad , Disfunción Cognitiva/etiología , Disfunción Cognitiva/terapia , Envejecimiento/fisiología , Demencia/terapia
9.
Clin Geriatr Med ; 39(1): 109-122, 2023 Feb.
Artículo en Inglés | MEDLINE | ID: mdl-36404024

RESUMEN

Aging, familial gene mutations, and genetic, environmental, and modifiable lifestyle risk factors predispose individuals to cognitive impairment or dementia by influencing the efficacy of multiple, often interdependent cellular and molecular homeostatic pathways mediating neuronal, glial, and vascular integrity and, ultimately, cognitive status. This review summarizes data from foundational and recent breakthrough studies to highlight common and differential vascular and nonvascular pathogenic mechanisms underlying the progression of Alzheimer disease, vascular dementia, frontotemporal dementia, and dementia with Lewy bodies.


Asunto(s)
Enfermedad de Alzheimer , Disfunción Cognitiva , Humanos , Disfunción Cognitiva/etiología , Enfermedad de Alzheimer/etiología , Envejecimiento , Factores de Riesgo
10.
Int J Aging Hum Dev ; 96(1): 6-18, 2023 Jan.
Artículo en Inglés | MEDLINE | ID: mdl-35950230

RESUMEN

This brief report provides an overview of lessons learned through evaluation of the first five years of the NIA-funded South Carolina-Advancing Diversity in Aging Research (SC-ADAR) undergraduate program, whose goal is to increase the number of qualified underrepresented minority (URM) students who pursue scientific graduate studies in programs focusing on medicine, science, technology, engineering, and mathematics and aging. Partnering with five Historically Black Colleges and Universities in South Carolina, we implemented a research training approach that included two consecutive summers of research training in a University of South Carolina faculty laboratory, as part of a comprehensive 24-month research education program. In addition to the mentored research experience in a laboratory, students had coursework in the biology of aging and social gerontology, with additional workshops tailored to emergent student needs including basic academic skills development, work-life management skills, reflective social experiences, and enhanced support in the transition from undergraduate to graduate school. We provide an overview of lessons learned throughout the early program period, and a description of the iterative changes we made in the program in response to this learning, all of which have been incorporated into the existing SC-ADAR program.


Asunto(s)
Gerociencia , Grupos Minoritarios , Humanos , Estudiantes , Mentores , Envejecimiento
11.
Methods Mol Biol ; 2589: 95-110, 2023.
Artículo en Inglés | MEDLINE | ID: mdl-36255620

RESUMEN

Sirtuins are identified as NAD+-dependent class III histone deacetylases (HDAC) and are involved in a variety of cellular activities, including energy metabolism, DNA repair, epigenetics, gene expression, cell proliferation, differentiation, and survival. Using genetically modified model organisms, sirtuins are proved to be one of the most conserved aging-regulatory and longevity-promoting genes/pathways among species. Of the seven sirtuins, SIRT7 is the only sirtuin that localizes in the nucleolus. SIRT7 senses endogenous and environmental stress to maintain physiological homeostasis. Sirt7 deficient and transgenic mice provide a useful tool to understand the mechanisms of aging and related pathologies. In this chapter, we summarized the most widely applied methods to understand the physiopathological function of SIRT7 in mice.


Asunto(s)
Sirtuinas , Ratones , Animales , Sirtuinas/genética , Sirtuinas/metabolismo , NAD/metabolismo , Envejecimiento/genética , Epigénesis Genética , Metabolismo Energético
12.
Physiol Rev ; 103(1): 609-647, 2023 01 01.
Artículo en Inglés | MEDLINE | ID: mdl-36049114

RESUMEN

Cardiovascular diseases (CVDs) constitute the prime cause of global mortality, with an immense impact on patient quality of life and disability. Clinical evidence has revealed a strong connection between cellular senescence and worse cardiac outcomes in the majority of CVDs concerning both ischemic and nonischemic cardiomyopathies. Cellular senescence is characterized by cell cycle arrest accompanied by alterations in several metabolic pathways, resulting in morphological and functional changes. Metabolic rewiring of senescent cells results in marked paracrine activity, through a unique secretome, often exerting deleterious effects on neighboring cells. Here, we recapitulate the hallmarks and key molecular pathways involved in cellular senescence in the cardiac context and summarize the different roles of senescence in the majority of CVDs. In the last few years, the possibility of eliminating senescent cells in various pathological conditions has been increasingly explored, giving rise to the field of senotherapeutics. Therefore, we additionally attempt to clarify the current state of this field with a focus on cardiac senescence and discuss the potential of implementing senolytics as a treatment option in heart disease.


Asunto(s)
Enfermedades Cardiovasculares , Humanos , Envejecimiento/fisiología , Calidad de Vida , Senescencia Celular/fisiología
13.
Int J Aging Hum Dev ; 96(1): 33-50, 2023 Jan.
Artículo en Inglés | MEDLINE | ID: mdl-35673267

RESUMEN

Using the 2006-2016 wave of Health and Retirement Study and Korean Longitudinal Study of Aging, this study explores the gender disparities in the health of older adults in the United States and South Korea. A logit model is adopted to explore the differences in the likelihood of aging healthily by gender in two countries. Results indicate that older females in the United States have a significantly higher probability of healthy aging than their male counterparts. However, the opposite finding is demonstrated among the older population in South Korea. These results are verified using various robustness check methods. The heterogeneities in the gender disparities in healthy aging across age groups and income levels are further explored. The gender effect in each healthy aging domain is investigated to understand the underlying causes of gender disparities. These findings can provide cross-national insights for policymakers to establish targeted aging policies with a gender perspective.


Asunto(s)
Envejecimiento Saludable , Femenino , Estados Unidos , Humanos , Masculino , Anciano , Estudios Longitudinales , República de Corea/epidemiología , Jubilación , Envejecimiento
14.
Int J Aging Hum Dev ; 96(1): 3-5, 2023 Jan.
Artículo en Inglés | MEDLINE | ID: mdl-35815703

RESUMEN

The following papers represent an early contribution of the National Institute on Aging's commitment to support high-quality research and mentor a more diverse workforce in the field of aging. The International Journal of Aging and Human Development has previously issued calls for such scholarship and has provided opportunities to share some of their teaching techniques that foster and support the next generation of gerontologists. In this issue, we feature both lessons learned from those who design and supervise National Institute of Aging-supported training programs and we highlight some of the work that these diverse scholars are contributing to the field. We hope that by disseminating "lessons learned" and specific research pieces, other labs will begin similar programs. We encourage others to develop and implement innovative training models and explore some of the funding opportunities available to support increasing diversity in aging.


Asunto(s)
Envejecimiento , Gerociencia , Humanos , Recursos Humanos
15.
Gene ; 850: 146955, 2023 Jan 20.
Artículo en Inglés | MEDLINE | ID: mdl-36220447

RESUMEN

The present research aims to evaluate the effect of swimming exercise and chitosan-coated l-arginine on mitochondrial oxidation, BCL2 Interacting Protein 3 (Bnip3), NIP-like protein × (Nix), B-cell lymphoma-extra-large (Bcl-xL) and autophagy-related protein light chain 3(LC3) expression in soleus muscle of aging rats. In this experimental research, 25 male Wistar rats were assigned into five groups randomly: young, old, old + Nano l-arginine (Nano L-a), old + exercise (Ex), and old + Nano l-arginine (Nano L-a) + exercise (Ex) (n = 5 in each). They performed a swimming exercise program five days a week for six weeks. To determine the relative strength for rats before and after performing these interventions, the 1repetition maximum (1RM) test was done as a pre and post-test. The exercise program started with 20 min and after four sessions, gradually increased to 60 min and this time was maintained until the completion of the training period. l-arginine coated with chitosan nanoparticles was given to the rats in the l-arginine-supplemented group via gavage at a dosage of 500 mg/kg/day, five days a week, for six weeks. Additionally, the rats in all groups were fed a normal diet (2.87 kcal/g and 15 % energy from fat). Upon the completion of the protocol implementation, the rats were sacrificed and the soleus muscle was fixed and frozen to determine hematoxylin and eosin (H&E) staining, immunohistochemistry (IHC), gene expression analysis, levels of reactive oxygen species (ROS), and total antioxidant capacity (TAC). The results from the present research indicated that swimming exercise and Nano l-arginine improve the strength and histology of muscle tissue in old rats (p < 0.05). Aging significantly increased the expression of Nix and Bnip3 (p < 0.05) and reduced the Bcl-xL gene expression (p < 0.05). The expression of LC3 protein also increased with aging (p < 0.05). Therapeutic interventions, such as combined treatment (old + Nano L-a + Ex) for old animals, reduced the amount of this protein in soleus muscle (p < 0.05). The ROS values also showed a significant reduction only in the old + Nano L-a + Ex group compared to the old group. Moreover, TAC values show a significant decrease in the old and old + Ex groups in comparison to the young group. The use of arginine supplement, especially in nano form, along with swimming exercise seems to reduce the oxidative damage to the elderly muscle tissue, which has a positive effect on the structure and function of the soleus muscle. Since these interventions only had a significant effect on LC3 protein, further studies with more diverse measurement methods for autophagy are suggested.


Asunto(s)
Quitosano , Condicionamiento Físico Animal , Animales , Masculino , Ratas , Envejecimiento/metabolismo , Antioxidantes/farmacología , Arginina/farmacología , Arginina/metabolismo , Autofagia , Proteínas Relacionadas con la Autofagia/metabolismo , Quitosano/farmacología , Suplementos Dietéticos , Eosina Amarillenta-(YS)/metabolismo , Eosina Amarillenta-(YS)/farmacología , Hematoxilina/metabolismo , Hematoxilina/farmacología , Músculo Esquelético/metabolismo , Estrés Oxidativo , Condicionamiento Físico Animal/fisiología , Proteínas Proto-Oncogénicas c-bcl-2/metabolismo , Ratas Wistar , Especies Reactivas de Oxígeno/metabolismo , Natación
16.
Behav Brain Res ; 437: 114151, 2023 Feb 02.
Artículo en Inglés | MEDLINE | ID: mdl-36216142

RESUMEN

Temporal order memory refers to the ability to remember the order of occurrence of items across time. It is a critical feature of episodic memory that is often tested in rodents using spontaneous object recognition paradigms. However, impact of aging over performances of temporal order memory decline is barely known. Herein, we characterized here the effect of normal aging on the temporal order memory performances in NMRI mice between 3 and 19months of age, with an inter-session interval of 24h.We found that temporal order memory was impaired as soon as7 months of age. These results provide strong evidence that temporal order memory is particularly vulnerable to the deleterious effect of normal aging.


Asunto(s)
Envejecimiento , Trastornos de la Memoria , Animales , Ratones , Envejecimiento/psicología , Trastornos de la Memoria/psicología , Memoria Episódica , Ratones Endogámicos , Reconocimiento en Psicología
17.
Arch Gerontol Geriatr ; 104: 104801, 2023 Jan.
Artículo en Inglés | MEDLINE | ID: mdl-36081231

RESUMEN

BACKGROUND: Some research suggests social isolation and loneliness are important risk factors for reduced successful aging and cognitive health. However, findings are inconsistent and no prior systematic review has investigated whether social isolation and loneliness are associated with the memory domain of cognition. This review examined whether social isolation and loneliness individually and jointly affected the memory of middle- and older-aged adults. METHODS: We used PubMed, PsycInfo, and Scopus to search for comparative studies that examined the impact of both loneliness and social isolation (e.g., social activity, social networks) on memory (including all subtypes) in populations aged ≥ 45 years. Three raters performed data extraction and risk of bias assessment using the Joanna Briggs Institute checklist. Data were synthesized narratively following the Synthesis without Meta-Analysis guideline. RESULTS: In 12 included articles, higher levels of loneliness and social isolation (combining a range of different indicators) were associated with lower memory performance, where the interaction between loneliness and social isolation had the largest adverse effect on memory, followed by social isolation alone, and followed by loneliness alone. However, substantial heterogeneity was observed in the composition of the two most common indicators of social isolation (social network size, social activity participation), with the magnitude of most results being clinically non-important. Most articles had moderate risk of bias. CONCLUSION: This review found an inverse association between social isolation/loneliness and memory, and outlines future steps to systematically combine the two constructs and measure social isolation in a consistent, multi-modal format.


Asunto(s)
Soledad , Aislamiento Social , Humanos , Adulto , Persona de Mediana Edad , Soledad/psicología , Aislamiento Social/psicología , Factores de Riesgo , Envejecimiento , Cognición
18.
Arch Gerontol Geriatr ; 104: 104823, 2023 Jan.
Artículo en Inglés | MEDLINE | ID: mdl-36179459

RESUMEN

OBJECTIVE: This study aimed to assess the longitudinal predictions between glycated hemoglobin A1c (HbA1c) and physical performance scores in different epidemiological contexts of aging. MATERIAL AND METHODS: Longitudinal data of 1,337 older people from three countries (Canada, Brazil and Colombia) of the International Mobility in Aging Study (IMIAS) were used to assess the relationship between HbA1c and Short Physical Performance Battery (SPPB) scores between 2012 and 2016. Linear Mixed Models grouped by sex and adjusted by Age, Study site, Chronic Conditions, Anthropometric Measures, and Inflammatory Level were used to estimate the influence of HbA1c and covariates on SPPB scores. RESULTS: At the IMIAS baseline, Latin American (LA) cities had higher HbA1c averages compared to Canadian cities, with Natal (Brazil) being the city with the highest HbA1c averages in men and women (6.32 ± 1.49; 6,56 ± 1.70 respectively). SPPB scores were significantly lower in LA cities, and older people in Natal had lower SPPB averages in men (9.67 ± 2.38; p-value < 0.05) and women (8.52 ± 2.33; p-value <0.05). In the multivariate mixed linear models of longitudinal analyses, HbA1c was significantly associated with lower SPPB scores in men (ß = -0.25, 95% CI: -0.39 to -0.12, p-value = 0.02) but not in women. CONCLUSION: High HbA1c levels at baseline were longitudinally associated in older adults from different countries, and this association was observed only in men and not in women. This study highlights a possible influence of gender on this relationship.


Asunto(s)
Envejecimiento , Rendimiento Físico Funcional , Masculino , Humanos , Femenino , Anciano , Hemoglobina A Glucada , Canadá/epidemiología , Brasil/epidemiología , Estudios Longitudinales
19.
Arch Gerontol Geriatr ; 104: 104825, 2023 Jan.
Artículo en Inglés | MEDLINE | ID: mdl-36183524

Asunto(s)
Envejecimiento , Libros , Humanos
20.
Arch Gerontol Geriatr ; 104: 104828, 2023 Jan.
Artículo en Inglés | MEDLINE | ID: mdl-36206719

RESUMEN

Vascular media and adventitia-induced remodeling plays an important role in vascular aging. However, the mechanism remains unclear. This study aims to investigate the mechanisms underlying vascular aging. Transcriptome analysis revealed that the expression of cathepsin L (CTSL) significantly decreased in arteries of old mice (24 months old) compared with that in arteries of young mice (4 months old), which was confirmed by immunohistochemistry and Western blot. The expression of CTSL in adventitia fibroblasts (AFs) and vascular smooth muscle cells (VSMCs) of aged mice was lower than that of young mice. Compared with wild-type control mice, CTSL knockout (CTSL - /-) mice had increased collagen deposition (fibrosis) and decreased telomerase activity and LC3Ⅱ/ LC3Ⅰratio. The expression of mammalian target of rapamycin (mTOR) and osteopontin (OPN) increased in aortas of CTSL-/-mice compared with that in aortas of wild-type control mice. In vitro, lentivirus-mediated CTSL knockdown induced VSMCs senescence and AFs transformed into myofibroblasts (MFs). Rapamycin, a mTOR inhibitor, inhibited CTSL deficiency induced VSMCs senescence, osteopontin (OPN) secretion and AFs migration. In conclusion, the decreased level of CTSL with age may participate in vascular aging by promoting the phenotypic transformation of vascular cells.


Asunto(s)
Osteopontina , Serina-Treonina Quinasas TOR , Ratones , Humanos , Animales , Catepsina L/genética , Catepsina L/metabolismo , Osteopontina/metabolismo , Ratones Noqueados , Envejecimiento , Mamíferos/metabolismo
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