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1.
J Med Case Rep ; 18(1): 327, 2024 Jul 09.
Artículo en Inglés | MEDLINE | ID: mdl-38978093

RESUMEN

BACKGROUND: Red Ear Syndrome is a burning sensation and erythema of the ear, associated with a various number of disorders including migraine, trigeminal neuralgia, autoimmune disorders etc. Theories for RES pathophysiology have developed from current understandings of comorbid conditions. Characterizing the underlying mechanism of RES is crucial for defining effective treatments. CASE PRESENTATION: Three caucasian patients, ages 15, 47, and 67 years, with migraine, one with erythromelalgia are reported in this manuscript. RES pathophysiology is not fully understood due to its variable clinical presentation and numerous comorbid conditions, making it difficult to identify effective treatments. CONCLUSION: RES seems to be largely treatment-resistant, and most options involve treating the associated disorders and minimizing pain. Further investigation of future cases should lead to a more comprehensive understanding of the fundamental cause of RES and, hopefully, successful treatments.


Asunto(s)
Eritema , Trastornos Migrañosos , Humanos , Femenino , Persona de Mediana Edad , Trastornos Migrañosos/fisiopatología , Trastornos Migrañosos/diagnóstico , Anciano , Adolescente , Masculino , Síndrome , Eritromelalgia/diagnóstico , Eritromelalgia/fisiopatología , Enfermedades del Oído/diagnóstico
4.
Skin Res Technol ; 30(6): e13735, 2024 Jun.
Artículo en Inglés | MEDLINE | ID: mdl-38899754

RESUMEN

INTRODUCTION: Rosacea is a chronic inflammatory skin condition associated with erythema, inflammation and skin sensitivity. OBJECTIVES: To assess the benefit of a dermocosmetic cream (DC cream) containing Sphingobioma xenophaga extract and soothing agent in adult females with rosacea-associated erythema and sensitive skin. MATERIALS AND METHODS: During phase 1, DC was applied twice daily on the randomized half-face and compared to usual-skincare (USC) for 28 days. During phase 2, DC was applied on the full face twice daily for 56 days. Clinical, instrumental and skin sensitivity assessments were performed at all visits; demodex density (standardized skin surface biopsy (SSSB) method) was performed at baseline and D28, quality of life (QoL) was assessed using the stigmatization questionnaire (SQ), Rosacea Quality of Life index (ROSAQoL) and Dermatology Life Quality Index (DLQI) at baseline and D84. RESULTS: At D28, a significant benefit of DC over USC was observed for erythema, tightness, burning and stinging (all p ≤ 0.05), erythema measured by chromameter (p < 0.01), corneometry and transepidermal water loss (p < 0.0001 and p < 0.05, respectively), skin sensitivity (p < 0.001) and significant reduction of mean demodex density (p < 0.05) on the DC side. At D84, DC significantly (all p < 0.05) improved clinical signs and symptoms on both sides of the face compared to baseline; SQ, ROSAQoL and DLQI scores improved by 40.4%, 25.0% and 55.7%, respectively compared to baseline. Tolerance was excellent. CONCLUSION: DC significantly improved erythema, skin sensitivity, demodex count, QoL and feeling of stigmatization of subjects with rosacea and is very well tolerated.


Asunto(s)
Eritema , Calidad de Vida , Rosácea , Crema para la Piel , Humanos , Rosácea/tratamiento farmacológico , Rosácea/complicaciones , Femenino , Persona de Mediana Edad , Adulto , Eritema/tratamiento farmacológico , Crema para la Piel/administración & dosificación , Animales , Anciano
6.
J Wound Care ; 33(6): 425-430, 2024 Jun 02.
Artículo en Inglés | MEDLINE | ID: mdl-38843011

RESUMEN

OBJECTIVE: This study aimed to measure the effectiveness of neuromuscular taping (NMT) form I (a polyacrylate tape 0.6cm wide and 30cm long) on wound temperature and erythema in diabetic foot ulcers (DFUs) as an initial study in NMT intervention trials. METHOD: The study employed a quasi-experimental pretest and post-test design with a seven-day observation. The research sample was 38 patients with DFU grades 2 and 3. The sample was divided into two groups: the control group (n=19) and the intervention group (n=19). In wound care, the modern dressing was applied to both groups while NMT was applied to the intervention group in form I with 30cm long and 6mm wide strips, and on the proximal, distal and lateral sides. The wound bed temperature was measured with a non-contact infrared thermometer, and erythema was measured with Corel Photo-Paint X5 software (Corel Corp, Canada). Statistical analysis between the two groups was carried out using the Mann-Whitney test, independent t-test and Chi-squared test with p< 0.05 representing statistical significance. RESULTS: The preliminary results revealed that no statistically significant differences (p>0.05) were noted between the groups in sociodemographic or clinical characteristics, including age, body mass index, blood sugar, duration of diabetes, sex, smoking history, wound temperature and degree of erythema. Finally, it was also observed that, after seven days of application, NMT form I increased wound bed temperature, and reduced the level of erythema (p<0.05). CONCLUSION: In this study, NMT form I has been shown to increase the wound bed temperature and reduce the degree of erythema in DFUs.


Asunto(s)
Pie Diabético , Eritema , Humanos , Masculino , Femenino , Eritema/etiología , Persona de Mediana Edad , Pie Diabético/terapia , Anciano , Cicatrización de Heridas , Cinta Quirúrgica , Temperatura Corporal , Vendajes , Adulto , Resultado del Tratamiento
7.
Sci Rep ; 14(1): 14673, 2024 06 25.
Artículo en Inglés | MEDLINE | ID: mdl-38918427

RESUMEN

Visual assessment, while the primary method for pigmentation and erythema evaluation in clinical practice, is subjective, time-consuming, and may lead to variability in observations among clinicians. Objective and quantitative techniques are required for a precise evaluation of the disease's severity and the treatment's efficacy. This research examines the precision and utility of a newly developed skin imaging system in assessing pigmentation and erythema. Sixty participants were recruited, and their facial images were analyzed with the new OBSERV 520 x skin imaging system, compared to DERMACATCH for regional analysis and VISIA for full-face examination. The degree of skin pigmentation was clinically graded using the MASI scores evaluated by dermatologists. The data revealed positive correlations between the novel skin imaging system and the two conventional instruments in quantifying pigmentation and erythema, whether in regional or full-face analysis. Furthermore, the new skin imaging system positively correlated with the clinical MASI scores (r = 0.4314, P < 0.01). In contrast, our study found no significant correlation between the traditional system and clinical assessment, indicating a more substantial capacity for hyperpigmentation assessment in the new system. Our study validates the innovative skin imaging system's accuracy in evaluating pigmentation and erythema, demonstrating its feasibility for quantitative evaluation in both clinical and research purposes.


Asunto(s)
Eritema , Cara , Pigmentación de la Piel , Humanos , Femenino , Masculino , Adulto , Eritema/diagnóstico por imagen , Cara/diagnóstico por imagen , Persona de Mediana Edad , Piel/diagnóstico por imagen , Piel/patología , Adulto Joven , Inflamación/diagnóstico por imagen , Anciano , Trastornos de la Pigmentación/diagnóstico por imagen , Trastornos de la Pigmentación/diagnóstico , Hiperpigmentación/diagnóstico por imagen
8.
Arch Dermatol Res ; 316(7): 359, 2024 Jun 08.
Artículo en Inglés | MEDLINE | ID: mdl-38850412

RESUMEN

Post-acne erythema (PAE) is a bothering skin condition that emerges from inflammatory acne and persists after its resolution. It is characterized by telangiectasia and erythematous macules. the role of 1064-nm Nd: YAG when combined with low-dose isotretinoin in the acne erythema treatment. forty-eight PAE patients were involved in the study. They were divided into two groups; group (A) patients administering a low dose of oral isotretinoin (10 mg/day) and underwent a total of six two-week interval sessions of 1064 ND-YAG laser treatment, group (B) patients administering a low dose of oral isotretinoin (10 mg/day) only. All adverse effects experienced during the course of therapy were documented, and photos were taken before the start of the treatment and following the end of the treatment duration. Following the completion of the therapeutic intervention, a significant improvement in clinical condition was observed in both groups, with more improvement in group (A) compared to group (B) as evidenced by a notable improvement in the score on the Clinician Erythema Assessment Scale (CEAS) and also a significant decrease in the mean value of optical density of the erythema. combined 1064-nm Nd: YAG with low-dose isotretinoin may be an efficient and secure line in the PAE treatment. Also, the combined therapy had superior results when compared to low-dose isotretinoin alone.


Asunto(s)
Acné Vulgar , Fármacos Dermatológicos , Eritema , Isotretinoína , Láseres de Estado Sólido , Humanos , Isotretinoína/administración & dosificación , Isotretinoína/efectos adversos , Isotretinoína/uso terapéutico , Eritema/etiología , Eritema/diagnóstico , Eritema/tratamiento farmacológico , Acné Vulgar/tratamiento farmacológico , Acné Vulgar/terapia , Acné Vulgar/diagnóstico , Femenino , Masculino , Láseres de Estado Sólido/uso terapéutico , Láseres de Estado Sólido/efectos adversos , Adulto , Fármacos Dermatológicos/administración & dosificación , Fármacos Dermatológicos/efectos adversos , Adulto Joven , Resultado del Tratamiento , Adolescente , Terapia Combinada/métodos , Terapia Combinada/efectos adversos
10.
J Eur Acad Dermatol Venereol ; 38 Suppl 6: 17-25, 2024 Jul.
Artículo en Inglés | MEDLINE | ID: mdl-38828801

RESUMEN

BACKGROUND: Ablative fractional CO2 laser is widely used to address various skin problems, but the treatment often leads to adverse effects such as erythema, dyspigmentation, and extended recovery periods, negatively impacting patients' quality of life. OBJECTIVES: This study aimed to evaluate the efficacy and safety of a topical skincare regimen containing both CE Ferulic serum and Resveratrol BE night serum following fractional CO2 laser treatment in Chinese population. METHODS: In this randomized, investigator-blinded, split-face, controlled trial, individuals aged 18-65 undergoing ablative CO2 laser treatment were randomly assigned to apply CE Ferulic plus resveratrol BE serum (CEF-RBE) to either side of face and normal saline (NS) to the other, for 14 consecutive days. The primary endpoint was erythema index (EI) on day 14, with key secondary endpoints including scabbing detachment time, percentage changes in EI and melanin index (MI), skin hydration, transepidermal water loss, skin sebum content, oedema, and overall subject satisfaction. RESULTS: The study included 51 patients, of whom 29 (56.9%) were female, with a mean (SD) age of 29.8 (5.39) years. On day 14, the CEF-RBE side exhibited significantly lower EI than the NS side (308.9 vs. 325.3, p = 0.034). The median (IQR) time (days) for complete scabbing detachment at the CEF-RBE side was 6.0 (5.0-8.0) compared to 6.5 (5.0-9.0) at NS side (p = 0.018). Additionally, the CEF-RBE side showed a 7.4% decrease in MI from baseline to day 14, while the NS side experienced a 0.2% increase (Δ = -7.6%, p = 0.044). Throughout the 14-day follow-up, the CEF-RBE side consistently displayed higher skin hydration than the NS side. CONCLUSIONS: The study highlighted the benefits of incorporating CEF-RBE following laser treatment in reducing erythema and hyperpigmentation, promoting wound healing, and maintaining skin hydration, although limitations such as contamination and adherence issues should be considered.


Asunto(s)
Láseres de Gas , Resveratrol , Humanos , Femenino , Adulto , Masculino , Láseres de Gas/uso terapéutico , Láseres de Gas/efectos adversos , Persona de Mediana Edad , Resveratrol/administración & dosificación , Estudios Prospectivos , Adulto Joven , Eritema/etiología , Adolescente , Método Simple Ciego , Anciano , Cuidados de la Piel/métodos , Satisfacción del Paciente , Administración Cutánea , Ácidos Cumáricos
11.
J Cosmet Dermatol ; 23 Suppl 2: 1-11, 2024 Jul.
Artículo en Inglés | MEDLINE | ID: mdl-38922798

RESUMEN

BACKGROUND: Specialized aesthetic skincare treatments are an important part of helping reduce facial signs of aging. AIMS: This article highlights real-world experience with a Macrocystis pyrifera ferment-containing skincare regimen comprising a cleansing foam, a serum, and a moisturizer with anti-aging, anti-inflammatory, anti-erythema, and healing properties for facial skin condition improvement. PATIENTS/METHODS: The real-world case (RWC) series presented highlights and the expert panel's clinical experience with the M. pyrifera ferment-containing skincare regimen used for 12 weeks to improve facial skin conditions. The panelists convened a meeting to discuss and select RWCs from their practice using the M. pyrifera ferment-containing skincare regimen. RESULTS: The RWC series showed that erythema and inflamed, easily irritated skin bother patients, even when it is mild. Reducing inflammation, erythema, and visible signs of facial aging and improving skin health contributed to patient satisfaction. CONCLUSION: The M. pyrifera ferment-containing skincare regimen comprising a cleansing foam, a serum, and a moisturizer is effective in decreasing the visible effects of inflammation and signs of aging while promoting healing by enhancing barrier resilience and recovery.


Asunto(s)
Cara , Rejuvenecimiento , Envejecimiento de la Piel , Cuidados de la Piel , Humanos , Envejecimiento de la Piel/efectos de los fármacos , Femenino , Persona de Mediana Edad , Cuidados de la Piel/métodos , Satisfacción del Paciente , Adulto , Eritema/tratamiento farmacológico , Anciano , Masculino , Resultado del Tratamiento
13.
Lasers Surg Med ; 56(5): 466-473, 2024 07.
Artículo en Inglés | MEDLINE | ID: mdl-38693708

RESUMEN

OBJECTIVES: To investigate the efficacy of Fractional Radiofrequency Microneedling (FRM) in treating corticosteroid-induced facial erythema. METHODS: A retrospective study was conducted involving eight patients diagnosed as corticosteroid-induced facial erythema. Each patient underwent a single session of FRM. Evaluative measures included Clinician's Erythema Assessment (CEA), Patient's Self-Assessment (PSA), assessment of telangiectasia severity, procedure-associated pain (10-point scale), patient satisfaction (3-point scale) and secondary outcomes. RESULTS: The study found a 75% success rate and 100% effectiveness rate in alleviating erythema symptoms. CEA and PSA scores decreased by 67.7% and 78.1%, respectively. No cases of erythema rebound were recorded during the 3-month follow-up period. CONCLUSIONS: FRM demonstrated effectiveness and safety in treating facial erythema, offering promising advancement in dermatologic therapeutics.


Asunto(s)
Eritema , Agujas , Humanos , Estudios Retrospectivos , Femenino , Eritema/etiología , Eritema/terapia , Adulto , Persona de Mediana Edad , Masculino , Agujas/efectos adversos , Resultado del Tratamiento , Terapia por Radiofrecuencia/efectos adversos , Dermatosis Facial/terapia , Corticoesteroides/uso terapéutico , Satisfacción del Paciente , Anciano , Inducción Percutánea del Colágeno
14.
Arch Dermatol Res ; 316(6): 215, 2024 May 24.
Artículo en Inglés | MEDLINE | ID: mdl-38787426

RESUMEN

Serpentine supravenous hyperpigmentation (SSH) describes increased skin pigmentation that develops in the area immediately overlying the vessels through which chemotherapeutic drugs are administered. While SSH can be cosmetically distressing and there are no definitive management options, the literature is severely limited and the variations in clinical presentation, risk factors, and histopathology of SSH across patients are not well understood. We aimed to systematically summarize characteristics from current available data, and thus improve SSH awareness and management. A literature search was conducted in PubMed using specific eligibility criteria through the end of December 2022. Included articles focused on patients who experienced SSH after chemotherapy infusion. Study quality was assessed using a modified Oxford Centre for Evidence-Based Medicine quality rating scheme. Of the 41 articles identified by literature search, 24 met eligibility criteria. Two additional articles were identified through the reference sections of retrieved articles, for 26 articles total. All articles were case reports, representing 28 patients total. Locations of SSH were mostly in the forearm near the site of injection (85%), and the most common associated symptom was erythema. Histopathologic analysis was available for half of cases, the majority of which were inflammatory in nature. The most common inflammatory pattern observed was a vacuolar/lichenoid interface dermatitis. Duration of SSH ranged from days to > 1 year after the chemotherapy was stopped. Six (21%) patients were managed with topical steroids and oral vasodilators, six (21%) patients switched to central venous infusion rather than peripheral infusion, five (18%) patients received only supportive care, three (11%) patients received venous washing with chemotherapy, three (11%) patients stopped chemotherapy, and one (4%) patient reduced the chemotherapy dosage. Ten (36%) patients attained complete resolution, seven (25%) had SSH that was near resolution/fading, and three (11%) had persistent hyperpigmentation. Although SSH often spontaneously resolves once the chemotherapeutic agent is stopped, it can persist in some patients and cause significant distress. As the literature is severely limited and there are no definitive treatments, additional research using more standardized definitions and methods of assessments is necessary to improve characterization of SSH and evaluate potential interventions.


Asunto(s)
Antineoplásicos , Hiperpigmentación , Humanos , Hiperpigmentación/inducido químicamente , Hiperpigmentación/diagnóstico , Antineoplásicos/efectos adversos , Pigmentación de la Piel/efectos de los fármacos , Piel/patología , Piel/efectos de los fármacos , Eritema/inducido químicamente , Eritema/diagnóstico
16.
Int J Mycobacteriol ; 13(1): 105-111, 2024 Jan 01.
Artículo en Inglés | MEDLINE | ID: mdl-38771288

RESUMEN

ABSTRACT: Lucio phenomenon (LP) is a variant of type two leprosy, characterized by necrotizing erythema, frequently found in neglected leprosy patient who experience delayed diagnosis or inappropriate treatment. Indonesia is in the third place for highest leprosy cases worldwide. Nonetheless, LP is less common, regardless being an endemic country. In this serial case, we describe the three cases of LP in lepromatous leprosy patients in Denpasar, Bali. All three cases came to our hospital with chronic wounds complained up to a year, accompanied by swollen leg, blisters, tingling sensation, and other symptoms. They had received no suitable treatment, proving LP as a neglected case in primary health care. After a period of treatment, however, patient lesions improved clinically with no physical disability. With this case series, a better understanding toward LP initial complains together with its natural history and further examination could be achieved; thus, improving the early diagnosis and management of LP.


Asunto(s)
Leprostáticos , Adulto , Femenino , Humanos , Masculino , Eritema/etiología , Eritema/patología , Indonesia , Leprostáticos/uso terapéutico , Lepra/complicaciones , Lepra/diagnóstico , Lepra/tratamiento farmacológico , Lepra Lepromatosa/diagnóstico , Lepra Lepromatosa/tratamiento farmacológico , Lepra Lepromatosa/patología , Lepra Lepromatosa/microbiología , Piel/patología , Piel/microbiología
17.
Acta Pharm ; 74(2): 301-313, 2024 Jun 01.
Artículo en Inglés | MEDLINE | ID: mdl-38815204

RESUMEN

The principal function of skin is to form an effective barrier between the human body and its environment. Impaired barrier function represents a precondition for the development of skin diseases such as atopic dermatitis (AD), which is the most common inflammatory skin disease characterized by skin barrier dysfunction. AD significantly affects patients' quality of life, thus, there is a growing interest in the development of novel delivery systems that would improve therapeutic outcomes. Herein, eight novel lyotropic liquid crystals (LCCs) were investigated for the first time in a double-blind, interventional, before-after, single-group trial with healthy adult subjects and a twice-daily application regimen. LCCs consisted of constituents with skin regenerative properties and exhibited lamellar micro-structure, especially suitable for dermal application. The short- and long-term effects of LCCs on TEWL, SC hydration, erythema index, melanin index, and tolerability were determined and compared with baseline. LCCs with the highest oil content and lecithin/Tween 80 mixture stood out by providing a remarkable 2-fold reduction in TEWL values and showing the most distinctive decrease in skin erythema levels in both the short- and long-term exposure. Therefore, they exhibit great potential for clinical use as novel delivery systems for AD treatment, capable of repairing skin barrier function.


Asunto(s)
Administración Cutánea , Dermatitis Atópica , Aceite de Linaza , Cristales Líquidos , Piel , Humanos , Cristales Líquidos/química , Método Doble Ciego , Adulto , Masculino , Femenino , Piel/efectos de los fármacos , Piel/metabolismo , Dermatitis Atópica/tratamiento farmacológico , Aceite de Linaza/química , Aceite de Linaza/farmacología , Adulto Joven , Eritema/tratamiento farmacológico , Cannabis/química , Persona de Mediana Edad , Sistemas de Liberación de Medicamentos/métodos , Extractos Vegetales
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