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1.
Braz Oral Res ; 35: e059, 2021.
Artículo en Inglés | MEDLINE | ID: mdl-34076186

RESUMEN

This study aimed to verify, through a longitudinal follow-up, the pre-, peri- and postnatal factors associated with the eruption of deciduous teeth. The study was nested in a Birth Cohort Study conducted in Pelotas, a Southern Brazilian city. Mothers were followed prenatally and their children were followed-up perinatally, at 3 and 12 months of age. The outcome was the number of teeth at 12 months, and exploratory variables included maternal habits and characteristics, anthropometric measures of children and mothers, and socioeconomic and demographic information. Data were collected through interviews with the mother and children's clinical exam. Poisson regression models were used for the analysis. Participants included 4,014 children with a mean number of erupted teeth at 12 months of 5.50. After adjustments, a lower mean number of teeth was observed in children from non-white mothers, early preterm children, and shorter children at birth and at 12 months. A higher number of teeth was observed for mothers with excessive weight gain during pregnancy, mothers who smoked during pregnancy, weightier children at birth and at 12 months, and for children with larger heads at birth and at 12 months. Our findings suggest that maternal and children characteristics influenced primary tooth eruption.


Asunto(s)
Erupción Dental , Diente Primario , Brasil/epidemiología , Niño , Estudios de Cohortes , Femenino , Humanos , Recién Nacido , Madres , Embarazo
2.
Arch Oral Biol ; 126: 105117, 2021 Jun.
Artículo en Inglés | MEDLINE | ID: mdl-33845260

RESUMEN

OBJECTIVE: Rodent incisors and molars show different eruption patterns. Dental follicles and their interaction with dental epithelia play key roles in tooth eruption. However, little is known about the differences between incisor dental follicle (IF) and molar dental follicle (MF) during tooth eruption of rodents. This study aimed to investigate the differences between IF and MF during tooth eruption under induction with cervical-loop cells (CLC) and Hertwig's epithelial root sheath (HERS) cells of rats. MATERIALS AND METHODS: CLC, HERS, IF, MF cells were isolated from 10 postnatal day 7 rats and identified by immunofluorescence staining. CLC or HERS cells-derived conditioned medium (CM) was obtained to induce IF and MF cells. Cell proliferation, mineralization, gene and protein expression related to tooth eruption were detected, and histological analysis was also performed. RESULTS: The osteogenic differentiation and mineralization abilities of IF cells were stronger than those of MF cells. Both CLC and HERS cells-derived CM enhanced these abilities of IF cells, whereas they showed the opposite effect on MF cells. At 7, 10, and 15 d after birth, IF cells expressed more OPG and less RANKL than MF cells. CONCLUSIONS: IF and MF cells present distinct characteristics in tooth eruption, CLC and HERS cells have significant inductive effects on them.


Asunto(s)
Saco Dental , Erupción Dental , Animales , Células Epiteliales , Incisivo , Diente Molar , Osteogénesis , Ratas , Roedores , Raíz del Diente
3.
Wiad Lek ; 74(3 cz 1): 441-449, 2021.
Artículo en Inglés | MEDLINE | ID: mdl-33813447

RESUMEN

OBJECTIVE: The aim is to determine the clinical and morphological dependencies, which are important for diagnostics, treatment and prediction of outcomes of pathological processes in the region of the LTM with complicated eruption, as based on the study of histopathological changes of paradental tissue (mucous membrane, walls of retromolar pocket, alveolar bone tissue). PATIENTS AND METHODS: Materials and methods: The materials of the study were 34 biopsy specimens of pathologically altered soft tissue and parodontium obtained as a result of pericoronectomy, extraction of the LTM and other surgical interferences performed based on the relevant indications in 28 patients in the region of the LTM with complicated eruption. Morphological and statistical research methods were used. RESULTS: Results: The local pathological processes, which chronologically precede the destructive changes in the hard tissue of a tooth (caries), are developed in patients of both genders with complicated LTM eruption in soft tissue of parodontium and the adjacent bone tissue of the alveolar wall in the majority of cases. As per biopsy examinations, the frequency of the main pathological processes in paradental tissue in case of complicated LTM eruption varies from 25 to 60 % of the number of biopsy specimens and occurs in various combinations in patients with different values of clinical parameters. The correlation relationships between the patients' clinical data and the morphological parameters of damage to paradental tissue are weak, multidirectional and uncertain in the majority of combinations (considering the available number of biopsy specimens studied). The close certain positive dependence between the damage of the squamous epithelium and the inflammation activity in the lamina propria mucosae, covering the tooth: in the vast majority of cases, the presence of damaged epithelium (within the biopsy specimen) is associated with the inflammation of high activity, was established as based on correlation relationships between the morphological parameters of damage to paradental tissue. CONCLUSION: Conclusions: The found pathological changes and the correlations justify surgical tactics on paradental soft and osseous tissues that are directed on the LTM sparing.


Asunto(s)
Tercer Molar , Erupción Dental , Femenino , Humanos , Masculino , Diente Molar , Tercer Molar/cirugía , Membrana Mucosa , Periodoncio
4.
Shanghai Kou Qiang Yi Xue ; 30(1): 13-16, 2021 Feb.
Artículo en Chino | MEDLINE | ID: mdl-33907772

RESUMEN

PURPOSE: To investigate the expression of hypoxia inducible factor-1alpha (HIF-1α) during the eruption of mouse lower first molar, and to explore the correlation between its expression and the activity of osteoclasts. METHODS: Mouse mandibles were dissected from mice at day 1.5 to 14.5 after birth. They were then serially sectioned and stained respectively using hemotoxylin, tartrate-resistant acid phosphatase (TRAP) staining, and immunohistochemical staining. SPSS 25.0 software package was used for data analysis. RESULTS: During the eruption of mouse lower first molar, the thickness of the crown alveolar bone gradually decreased, so did the number of osteoclasts and the expression of HIF-1α. CONCLUSIONS: During the eruption of mouse lower first molar, the less expression of HIF-1α, the fewer osteoclasts there were. HIF-1α may be involved in the eruption of mouse lower first molar by regulating the activity of osteoclasts.


Asunto(s)
Diente Molar , Erupción Dental , Animales , Hipoxia , Subunidad alfa del Factor 1 Inducible por Hipoxia/genética , Ratones , Osteoclastos , Fosfatasa Ácida Tartratorresistente
5.
BMC Oral Health ; 21(1): 180, 2021 04 07.
Artículo en Inglés | MEDLINE | ID: mdl-33827533

RESUMEN

BACKGROUND: A dentigerous cyst (DC) is a pathology embracing the crown of an unerupted tooth at risk of malignant transformation. The causal tooth is usually removed together with the cyst. However, if there are orthodontic contraindications for extraction, two questions arise. (1) Which factors favor spontaneous eruption? (2) Which factors imply the necessity of applying orthodontic traction? This systematic review aimed to identify factors conducive/inconducive to the spontaneous eruption of teeth after dentigerous cyst marsupialization. METHODS: In accordance with the PRISMA guidelines, the main research question was defined in the PICO format (P: patients with dentigerous cysts; I: spontaneous tooth eruption after surgical DC treatment; C: lack of a spontaneous tooth eruption after surgical DC treatment; O: determining factors potentially influencing spontaneous tooth eruption). The MEDLINE, EMBASE, and Cochrane Central Register of Controlled Trials databases were searched for keywords combining dentigerous/odontogenic/follicular cysts with teeth and/or orthodontics, as well as human teeth and eruption patterns/intervals/periods/durations. The following data were extracted from the qualified articles (4 out of 3005 found initially): the rate of tooth eruption after surgical treatment of the cyst, the age and sex of the patients, the perpendicular projection distance between the top of the tooth cusp and the edge of the alveolar process, tooth angulation, the root formation stage, the cyst area, and the eruption space. The articles were subjected to risk of bias and quality analyses with the ROBINS-I protocol and the modified Newcastle-Ottawa QAS, respectively. Meta-analyses were performed with both fixed and random effects models. The GRADE approach was used to evaluate the quality of the evidence. The systematic review was registered in PROSPERO under ID CRD42020189044. RESULTS: Nearly 62% of DC-associated premolars erupted spontaneously after cyst marsupialization/decompression. Young age (mean = 10 years) and root formation not exceeding 1/2 of its fully developed length were the factors likely to favor spontaneous eruption. CONCLUSION: The small number of published studies, as well as their heterogeneity and the critical risk of bias, did not allow the creation of evidence-based protocols for managing teeth with DC after marsupialization. More high-quality research is needed to draw more reliable conclusions.


Asunto(s)
Quiste Dentígero , Diente Impactado , Diente no Erupcionado , Diente Premolar , Niño , Quiste Dentígero/complicaciones , Quiste Dentígero/cirugía , Humanos , Erupción Dental , Diente Impactado/cirugía
6.
Ned Tijdschr Tandheelkd ; 128(3): 161-166, 2021 Mar.
Artículo en Holandés | MEDLINE | ID: mdl-33734222

RESUMEN

Eruption of mandibular second molars usually occurs around the age of 12. Incomplete eruption of second molars in such young patients can lead to loss of the molars, due to caries, root resorption or periodontal pathology. When a pathology of this kind develops, the treatment option for a mesially impacted molar is often to extract the tooth. If tooth eruption is, however, monitored closely by the dentist and/or orthodontist, early treatment can be considered in order to preserve the tooth. Partially impacted second molars can be placed in a functional anatomical position by surgical uprighting and repositioning. As long as certain conditions are met, this results in sound functionality with preservation of the full dentition. In cases of incomplete eruption, this treatment option should therefore be considered by dentists and orthodontists before extracting the second molars.


Asunto(s)
Mandíbula , Diente Impactado , Humanos , Diente Molar/cirugía , Tercer Molar , Erupción Dental , Técnicas de Movimiento Dental , Diente Impactado/cirugía
7.
Am J Orthod Dentofacial Orthop ; 159(2): e169-e177, 2021 Feb.
Artículo en Inglés | MEDLINE | ID: mdl-33546831

RESUMEN

INTRODUCTION: The present study aimed to analyze possible factors involved in irreversible (IRR) ectopic eruption (EE) of the first permanent molar and explore potential predictors for the IRR outcome. METHODS: Children aged 4-11 years, with at least 1 EE and who took their first panoramic radiograph before the age of 8 years, were selected in this study. The subjects were assigned to the self-correcting (SC) and IRR groups. Patients' age, sex, distribution of EE, and accompanying dental anomalies were recorded. Eruptive angulation (EA) of the first permanent molar, the grade of root resorption in the second deciduous molar, the magnitude of impaction index (MOII), and horizontal distance were measured on the panoramic radiographs. Chi-square tests and independent-sample t test were used for nominal and continuous variables, respectively. The receiver operative characteristic curve was used to determine the critical value. RESULTS: A total of 406 children with 634 first permanent molars, presenting EE, were enrolled, with 61.3% of the teeth in the SC group. Sex of children with EE and distribution of EE were not relevant to the IRR outcome. The presence of supernumerary teeth might be a protective factor for the IRR outcome. The increasing severity of root resorption in the second primary molar indicated an IRR outcome. A higher MOII and a larger EA suggested an IRR outcome with moderate-to-high quality. The horizontal distance exhibited debatable results, with a low predictive quality. CONCLUSION: Close monitoring and early intervention would benefit children with increasing severity of distal atypical resorption in the second primary molar, higher MOII, and larger EA.


Asunto(s)
Erupción Ectópica de Dientes , Niño , Preescolar , Arco Dental , Humanos , Diente Molar/diagnóstico por imagen , Radiografía Panorámica , Erupción Dental , Erupción Ectópica de Dientes/diagnóstico por imagen , Diente Primario
8.
Anat Sci Int ; 96(2): 301-309, 2021 Mar.
Artículo en Inglés | MEDLINE | ID: mdl-33433858

RESUMEN

A previous study suggested that fibroblast growth factor (FGF) signaling plays an important role in dentin formation during tooth development. In this study, to examine dentin formation after tooth eruption involving secondary and tertiary dentin, we analyzed the expression patterns and expressing cells of Fgfr1, -2c, and -3c in mouse maxillary first molars (M1). Since it is difficult to recover the mRNAs from mineralized tissues, we tested methods for extraction after fixation and decalcification of teeth. We successfully obtained consistent results with quantitative real-time PCR (qPCR) using ß-actin transcripts for validation. qPCR for Dentin sialo phosphoprotein (Dspp), Fgfr1, -2c, and -3c transcripts was performed on mice at ages of 2-20 weeks. The results showed that the highest expression levels of Dspp and Fgfr2c occurred at 2 weeks old followed by lower expression levels after 4 weeks old. However, the expression levels of Fgfr1 and Fgfr3c were constant throughout the experimental period. By in situ hybridization, Dspp, Fgfr1, and Fgfr3c transcripts were detected in odontoblasts at ages of 2 and 4 weeks. In addition, Dspp and Fgfr1 transcripts were detected in odontoblasts facing reactionary dentin at 8 weeks old. These results suggest that FGF-FGFR signaling might be involved in the regulation of odontoblasts even after tooth eruption, including secondary and tertiary dentin formation. Moreover, our modified method for extracting mRNA from mineralized tissues after fixation and decalcification successfully produced consistent results.


Asunto(s)
Diente Molar/metabolismo , Receptor Tipo 1 de Factor de Crecimiento de Fibroblastos/metabolismo , Receptor Tipo 2 de Factor de Crecimiento de Fibroblastos/metabolismo , Receptor Tipo 3 de Factor de Crecimiento de Fibroblastos/metabolismo , Erupción Dental/fisiología , Animales , Ratones , Odontoblastos/metabolismo , Receptor Tipo 1 de Factor de Crecimiento de Fibroblastos/genética , Receptor Tipo 2 de Factor de Crecimiento de Fibroblastos/genética , Receptor Tipo 3 de Factor de Crecimiento de Fibroblastos/genética
9.
J Clin Pediatr Dent ; 44(5): 352-355, 2020 Sep 01.
Artículo en Inglés | MEDLINE | ID: mdl-33181851

RESUMEN

Idiopathic gingival fibromatosis (IGF) is a rare, genetically heterogeneous condition that is usually a part of syndrome or, rarely, an isolated disorder. It is characterized by a slowly progressive, non hemorrhagic, fibrous enlargement of keratinized gingiva which usually begins at the time of eruption of permanent dentition, however very few cases involving the primary teeth have been described in literature. Congenital gingival fibromatosis is very rare condition in which the gingival tissues become thickened and erupting teeth remain submerged beneath hyperplastic tissue masses. This case report discusses the rare case of congenital non syndromic idiopathic gingival fibromatosis in a two year old boy who reported with absence of teeth and incompetent lips. Gingivectomy was done using modified microdissection electrocautery needle to remove the excess gingival tissues. Excised tissue has been examined histologically. The patient was followed up for a period of one year and no recurrence was observed.


Asunto(s)
Fibromatosis Gingival , Preescolar , Electrocirugia , Fibromatosis Gingival/cirugía , Encía , Gingivectomía , Humanos , Masculino , Erupción Dental
10.
Am J Orthod Dentofacial Orthop ; 158(6): 849-855, 2020 Dec.
Artículo en Inglés | MEDLINE | ID: mdl-33131921

RESUMEN

INTRODUCTION: The management of impacted, unerupted, or malpositioned mandibular second molars with orthodontic therapy requires special attention in order to achieve normal anatomic positioning within the dental arch. We present a surgical approach to managing these teeth combining exposure and surgically-assisted forced eruption. METHODS: This retrospective single-group cohort study followed 260 impacted mandibular second molars. The molars were exposed and surgically uprighted. An orthodontic bracket was bonded to aid in orthodontic traction, and the wound was packed to prevent soft tissue growth over the crown of the exposed molar. Patients were followed for a minimum of 6 months after uprighting, during which the following outcomes were measured: the degree of success of the eruption one the basis of the clinical occlusal relationship to the opposing dentition, radiographic evidence of bone fill, the periodontal status of the teeth involved, and tooth vitality. RESULTS: A total of 260 mandibular second molars were uprighted in 177 patients (83 female, 94 male) with an average age of 14.8 years. Outcomes showed that 255 molars (98.1%; 95% confidence interval, 96.3-99.8) were successfully uprighted. Complications included infection/abscess in 3 molars and fractured root requiring extraction in 2 molars. All remaining 255 teeth tested vital, 17 teeth had periodontal pocketing of more than 5 mm, and 235 of the teeth had occlusal contact after healing. CONCLUSIONS: Surgically-assisted forced eruption with or without orthodontic forced eruption is a safe, successful, and viable approach to managing unerupted or malpositioned mandibular second molars in the adolescent population.


Asunto(s)
Mandíbula , Diente Impactado , Adolescente , Estudios de Cohortes , Femenino , Humanos , Masculino , Mandíbula/cirugía , Diente Molar/diagnóstico por imagen , Diente Molar/cirugía , Tercer Molar , Estudios Retrospectivos , Erupción Dental , Técnicas de Movimiento Dental , Diente Impactado/diagnóstico por imagen , Diente Impactado/cirugía
11.
Orthod Fr ; 91(1-2): 47-55, 2020 06 01.
Artículo en Francés | MEDLINE | ID: mdl-33146132

RESUMEN

In their daily practice, orthodontists and pedo- dontists have a common aim which is to ensure a functional establishment of the permanent denture. Due to the increase of eruption defects/failures with no clear obstacles, the doctor may encounter some difficulties to elaborate a diagnosis or even feels helpless when in need to define and put in motion a correct therapeutic strategy. The primary failure of eruption (PFE) is an extensively studied disease that has to be distinguished from an ankylosis during the diagnosis to improve the patient care. A thorough research of scientific literature has been achieved in order to keep our knowledge on the subject up to date and to develop the diagnosis further on primary failure of eruption. The exploitation of scientific data as well as the use of imagery and genetics, provided us with helpful elements for the primary failure of eruption diagnosis. It also allows the pedodontist and the orthodontist to avoid an unsatisfactory patient care who will be informed prior to the start of the treatment.


Asunto(s)
Ortodoncistas , Anquilosis del Diente , Niño , Humanos , Diente Molar , Erupción Dental
12.
J Indian Soc Pedod Prev Dent ; 38(3): 211-215, 2020.
Artículo en Inglés | MEDLINE | ID: mdl-33004717

RESUMEN

Context: Delayed tooth eruption might be the primary or sole manifestation of local or systemic pathology. Aims: The aim of the study was to correlate Vitamin D level and eruption status of primary teeth. The objectives also included the assessment of the association between Vitamin D levels and socioeconomic status, infant's sun exposure, maternal sun exposure during pregnancy and religion. Settings and Design: A cross-sectional, observational study conducted on 96 infants aged 12-15 months. Materials and Methods: Ninety-six infants, aged 12-15 months were selected after obtaining parental consent. Blood samples were assessed for Vitamin D3 levels using the Vitamin D ELISA Kit. The eruption status of the teeth was recorded in all the 96 infants. The obtained data were subjected to the statistical analysis. Statistical Analysis Used: The obtained data were subjected to relevant statistical analysis such as Analysis of Variance, unpaired t-test, Kruskal-Wallis test, and Mann-Whitney U test, Chi-square Test, Tukey HSD, and Fisher's exact Test. Results: A significant correlation was found in the Vitamin D levels and the eruption timing (P < 0.001). The difference in mean Vitamin D levels among the three socio economic groups was not statistically significant (P = 0.088). A significant association was found between the infant's sun exposure and mother's sun exposure during pregnancy and religion on the Vitamin D levels (P = 0.002, P = 0.042, P = 0.002). Conclusions: Vitamin D deficiency can be considered as an etiological factor for delayed eruption. A strong association exists between the socioeconomic status, infant's sun exposure, maternal sun exposure during pregnancy, and religion with Vitamin D levels.


Asunto(s)
Erupción Dental , Deficiencia de Vitamina D , Estudios Transversales , Femenino , Humanos , Lactante , Embarazo , Diente Primario , Vitamina D
13.
J Indian Soc Pedod Prev Dent ; 38(3): 311-314, 2020.
Artículo en Inglés | MEDLINE | ID: mdl-33004731

RESUMEN

Eruption of the first tooth at 6 months of age is a significant stage in a child's life. However, the presence of a tooth in the oral cavity of a newborn can lead to a lot of delusions. Natal and neonatal teeth are of utmost importance not only to a dentist but also for a pediatrician due to parental anxiety, folklore superstitions, and numerous complications associated with it. The present case report describes a 1.5 cm × 1.5 cm, slow-growing, soft-tissue gingival mass which developed following the extraction of a tooth-like structure in a 4-month-old male patient. Histological examination revealed that it contained a tooth-like hard tissue intermingled with bone and fibrous tissue. Based on clinical and histological findings, the present case was diagnosed as gingival hyperplasia with displaced tooth buds of 71 and 81, which might be due to chronic irritation or traumatic extraction of the neonatal teeth. No abnormal recurrence of the lesion was detected during the follow-up period. However, postoperative clinical and radiographic photographs further reconfirmed the absence of tooth in relation to 71 and 81.


Asunto(s)
Dientes Neonatales/cirugía , Extracción Dental/efectos adversos , Huesos , Niño , Encía , Humanos , Lactante , Recién Nacido , Masculino , Erupción Dental
14.
J Am Dent Assoc ; 151(11): 857-862, 2020 Nov.
Artículo en Inglés | MEDLINE | ID: mdl-33121607

RESUMEN

BACKGROUND AND OVERVIEW: Ectopic eruption of permanent molars is one of the challenges that arise in the early mixed dentition period, particularly when the root of the primary second molar is resorbed due to mesial angulation of the impacted first molar. The authors introduce a simple and efficient method to unlock ectopically erupting first molars using a light wire. CASE DESCRIPTION: The authors describe the cases of 2 girls (8 and 7 years old) who sought treatment for locking of their maxillary and mandibular first molars, respectively. A 0.012-inch nickel titanium wire was compressed and bonded to the first molars and primary second molars to unlock the first molars. The primary second molars were splinted to the adjacent primary first molars and canines using bonded multistranded wires. As the compressed wires straightened over time, the locked first molars were tipped back without any substantial mesial movement of the primary teeth. After unlocking the molars, the nickel titanium wires were removed to allow spontaneous eruption of the first molars. CONCLUSIONS AND PRACTICAL IMPLICATIONS: Although the primary molar roots were considerably resorbed, the ectopically erupting first molars were unlocked successfully without any substantial movement of the primary teeth. The clinical procedure was simple, and no laboratory procedures were needed. In addition, the anchorage burden was reduced with the use of light forces. The authors suggest that primary second molars with substantial root resorption due to ectopic eruption of permanent first molars can be saved simply and efficiently.


Asunto(s)
Resorción Radicular , Erupción Ectópica de Dientes , Diente Impactado , Femenino , Humanos , Maxilar , Diente Molar/cirugía , Erupción Dental , Técnicas de Movimiento Dental , Diente Impactado/cirugía
15.
Eur J Paediatr Dent ; 21(3): 199-202, 2020 Sep.
Artículo en Inglés | MEDLINE | ID: mdl-32893652

RESUMEN

BACKGROUND: Odontomas are hamartomatous developmental malformations of the dental tissues. Usually asymptomatic, their presence is often revealed on routine radiographs. The study aimed to establish the efficacy of this conventional approach in treating odontomas, analysing clinical outcome, follow-up, and histomorphological profile. CASE REPORT: A case is presented with a review of the international literature. The patient, aged 8 years, had a complex odontoma localised on the front upper jaw. She was treated following the conventional surgical procedure. Post-operative course and healing were uneventful. Orthodontic treatment was necessary to realign the teeth. At the 12-month follow-up there was no recurrence or failure. Healing was excellent. CONCLUSION: Variations in normal tooth eruption are a common finding, but significant deviations from established norms should alert the clinician to further investigate the patient's health and development.


Asunto(s)
Odontoma , Diente Impactado , Niño , Femenino , Humanos , Maxilar , Recurrencia Local de Neoplasia , Erupción Dental
16.
Eur J Paediatr Dent ; 21(3): 227-234, 2020 Sep.
Artículo en Inglés | MEDLINE | ID: mdl-32893657

RESUMEN

AIM: Pre-eruptive intra-coronal resorption (PEIR) is a rare condition that can affect children's dentition. Showing the same aspect of dental caries, these lesions are diagnosed in non-erupted teeth. The aetiology is not yet defined and no consensus on their treatment is available. Thus, the aim of the present scoping review of the literature was to try to establish a protocol for treatment and management of PEIR defects. METHODS: The search was performed on Medline via PubMed, Science Direct and EBSCOhost' databases using the appropriate Medical Subject Headings (MESH) terms. Studies that described the PEIR were considered eligible and the data from the selected papers were extracted and analysed independently by two authors. RESULTS: Out of 172 articles identified in initial research, 15 articles were selected for reviewing. Interventions varied from preventive treatment to extraction, depending on the lesion severity and its proximity to the pulp. CONCLUSION: Non-operative procedures, conservative approaches and extractions were recommended for the management of PEIR, depending on the extent of the lesions. Overall, further researches should be conducted to explore the effectiveness of the approaches of PEIR management.


Asunto(s)
Caries Dental , Resorción Dentaria , Diente no Erupcionado , Niño , Pulpa Dental , Humanos , Erupción Dental
17.
Medicine (Baltimore) ; 99(39): e22352, 2020 Sep 25.
Artículo en Inglés | MEDLINE | ID: mdl-32991450

RESUMEN

BACKGROUND: Antiretroviral therapy for HIV in sub-Saharan Africa has transformed the highly infectious virus to a stable chronic condition, with the advent of Highly active antiretroviral therapy (HAART). The longterm effects of HAART on the oral health of children are understudied. OBJECTIVE: To compare the effect of lopinavir-ritonavir and lamivudine on oral health indicators (dental caries, gingivitis, tooth eruption, and oral health related quality of life) in 5 to 7 year old HIV-1 exposed uninfected children from the ANRS 12174 trial. METHODS: This study used data collected in 2017 among children aged 5 to 7 years from the Ugandan site of the ANRS 12174 randomized trial (ClinicalTrials.gov no: NCT00640263) implemented between 2009 and 2012 in Mbale district, Eastern Uganda. The intervention was lopinavir-ritonavir or lamuvudine treatment to prevent vertical HIV-1 transmission. One hundred thirty-seven and 139 children were randomized to receive lopinavir-ritonavir or lamivudine treatment at day 7 postpartum to compare efficacy of prevention of vertical HIV-1 transmission. At follow up, the children underwent oral examination using the World Health Organization methods for field conditions. The oral health related quality of life was assessed using the early childhood oral health impact scale. Negative binomial and logistic regression were used for the analysis of data. MAIN OUTCOME MEASURES: Dental caries, gingivitis, tooth eruption, and oral health related quality of life) in 5 to 7 year old HIV-1 exposed uninfected children. RESULTS: The prevalence of dental caries was 48% in the study sample: 49% in the lopinavir-ritonavir arm and 48% in the lamivudine treatment group. The corresponding mean decayed missing filled teeth and standard deviation was 1.7 (2.4) and 2.3 (3.7) The mean number (standard deviation) of erupted permanent teeth was 3.8 (3.7) and 4.6 (3.9) teeth in the lopinavir- and lamivudine group, respectively. The prevalence of reported impacts on oral health was 7% in the lopinavir-ritonavir and 18% in the lamivudine group. Gingivitis had a prevalence of 7% in the lopinavir-ritonavir and 14% lamivudine treatment group. The regression analysis revealed 70% less reported impacts on oral health in lopinavir-ritonavir group than the lamivudine treatment group with an incidence rate ratio of 0.3 (95% confidence interval: 0.1-0.9). CONCLUSIONS: HIV exposed uninfected infants in the lopinavir-ritonavir group reported less impacts on oral health than the lamivudine treatment group. Dental caries, gingivitis, and tooth eruption were not significantly affected by the treatment lopinavir-ritonavir or lamivudine. TRIAL REGISTRATION CLINICALTRIALS. GOV IDENTIFIER: NCT00640263.


Asunto(s)
Antirretrovirales/uso terapéutico , Terapia Antirretroviral Altamente Activa/métodos , Infecciones por VIH/tratamiento farmacológico , Salud Bucal/estadística & datos numéricos , Fármacos Anti-VIH/farmacología , Fármacos Anti-VIH/uso terapéutico , Estudios de Casos y Controles , Niño , Preescolar , Caries Dental/tratamiento farmacológico , Caries Dental/epidemiología , Quimioterapia Combinada , Femenino , Gingivitis/tratamiento farmacológico , Infecciones por VIH/prevención & control , Infecciones por VIH/transmisión , VIH-1/efectos de los fármacos , Humanos , Transmisión Vertical de Enfermedad Infecciosa/prevención & control , Lamivudine/farmacología , Lamivudine/uso terapéutico , Lopinavir/farmacología , Lopinavir/uso terapéutico , Masculino , Evaluación de Resultado en la Atención de Salud , Prevalencia , Calidad de Vida , Ritonavir/farmacología , Ritonavir/uso terapéutico , Erupción Dental/efectos de los fármacos , Uganda/epidemiología
18.
Dental Press J Orthod ; 25(4): 68-74, 2020.
Artículo en Inglés | MEDLINE | ID: mdl-32965389

RESUMEN

OBJECTIVE: To evaluate the skill of orthodontists and oral/maxillofacial surgeons (OMFS) in providing a prognosis of mandibular third molars spontaneously erupted, through follow-up panoramic analysis. METHODS: 22 orthodontic patients treated without extraction, presenting spontaneously erupted mandibular third molars (n = 44) were analyzed through panoramic serial radiographs. The first panoramic radiograph was obtained just after orthodontic treatment (PR1), in patients aging from 13 to 19 years. A second panoramic radiograph (PR2), was obtained in average two years later. The radiographs were randomly analyzed by 54 specialists, 27 orthodontists and 27 OMFS, to obtain the opinion about the approach to be adopted to these teeth in PR1. Then, another opinion was collected by adding a serial radiograph (PR1+2). RESULTS: The concordance of the answers was moderate for OMFS (Kappa 0.44; p< 0.0001) and significant for orthodontists (Kappa 0.39; p< 0.0001). In the analysis of the first radiograph (PR1) of the spontaneously erupted molars, OMFS indicated extraction in 44.5% of cases, while orthodontists indicated in 42%, with no difference between groups (p= 0.22). In PR1+2 analysis, orthodontists maintained the same level of extraction indication (45.6%, p= 0.08), while surgeons indicated more extractions (63.2%, p< 0.0001). CONCLUSIONS: Orthodontists and OMFS were not able to predict the eruption of the third molars that have erupted spontaneously. Both indicated extractions around half of the third molars. A follow-up analysis, including one more radiograph, did not improve the accuracy of prognosis among orthodontists and worsened for OMFS.


Asunto(s)
Tercer Molar/diagnóstico por imagen , Tercer Molar/cirugía , Diente Impactado/diagnóstico por imagen , Humanos , Mandíbula/diagnóstico por imagen , Diente Molar , Cirujanos Oromaxilofaciales , Ortodoncistas , Radiografía Panorámica , Erupción Dental , Extracción Dental
20.
Am J Orthod Dentofacial Orthop ; 158(5): 752-758, 2020 Nov.
Artículo en Inglés | MEDLINE | ID: mdl-32863085

RESUMEN

Nonmineralized cysts and cyst-like lesions that frequently occur in the mandible include ameloblastomas, odontogenic keratocysts, and dentigerous cysts. They have specific features of well-demarcated, unilocular, and radiolucent lesions that are often associated with tooth impaction. Although it rarely occurs, these cysts can become extremely large. Furthermore, cyst enlargement causes additional symptoms that can challenge the success of tooth recovery through orthodontic treatment. This clinical report presents the successful eruption of 2 impacted molars in a large dentigerous cyst treated with marsupialization and orthodontic traction using an orthodontic miniplate anchorage over a 4-year treatment period.


Asunto(s)
Quiste Dentígero , Quistes Odontogénicos , Diente Impactado , Quiste Dentígero/diagnóstico por imagen , Quiste Dentígero/cirugía , Humanos , Diente Molar/diagnóstico por imagen , Diente Molar/cirugía , Erupción Dental , Diente Impactado/diagnóstico por imagen , Diente Impactado/cirugía
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