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1.
Eur J Radiol ; 138: 109674, 2021 May.
Artículo en Inglés | MEDLINE | ID: mdl-33798932

RESUMEN

OBJECTIVES: We hypothesize that three-dimensional (3D) geometric analyses in weight bearing CT-images of the foot and ankle are more reproducible compared to two-dimensional (2D) analyses. Therefore, we compared 2D and 3D analyses on bones of weight-bearing and non weight-bearing cone-beam CT images of healthy volunteers. METHODS: Twenty healthy volunteers (10 male, 10 female, mean age 37.5 years) underwent weight-bearing and non weight-bearing cone-beam CT imaging of both feet. Clinically relevant height and angle measurements were performed in 2D and 3D (for example: cuboid height, calcaneal pitch, talo-calcaneal angle, Meary's angle, intermetatarsal angle). Three-dimensional measurements were obtained using automated software. Intra-observer and inter-observer agreement were evaluated for all 2D measurements. RESULTS: Overall intraclass correlation coefficients (ICC's) were higher than 0.750 for most 2D measurements, ranging from 0.352 to 0.995. Calcaneal pitch, angle between the first metatarsal (MT1) and proximal phalange 1, between the fifth metatarsal (MT5) and the calcaneus and heights of the sesamoid bones, navicular, cuboid and talus decreased during weight-bearing in both 2D and 3D results (p < 0.01). Meary's angle was not statistically different in 2D (p = 0.627) and 3D (p = 0.765). Higher coefficients of variation in 2D geometric analysis parameters (0.27 versus 0.16) indicate that 3D analyses are more precise compared to 2D (p < 0.01). Results of left and right feet are comparable for 2D and 3D analyses. CONCLUSION: Although 2D and 3D geometrical analyses are fundamentally different, automated 3D analyses are more reproducible and precise compared to 2D analyses. In addition, 3D evaluation better demonstrates differences in bone configurations between weight-bearing and non weight-bearing conditions, which may be of value to demonstrate pathology.


Asunto(s)
Tobillo , Tomografía Computarizada de Haz Cónico , Adulto , Articulación del Tobillo/diagnóstico por imagen , Femenino , Humanos , Masculino , Estándares de Referencia , Soporte de Peso
2.
Zhonghua Yu Fang Yi Xue Za Zhi ; 55(4): 545-550, 2021 Apr 06.
Artículo en Chino | MEDLINE | ID: mdl-33858070

RESUMEN

Tumor markers (TM) detection is of great significance in tumor screening, monitoring and treatment intervention, which puts forward higher requirements for its detection quality. TM traceability is very important in the process of reagent production and clinical laboratory testing, which can help improving the reliability and comparability of TM testing. Based on the current principles and classification system of metrology traceability in the world, this paper reviews the quality requirements of reference materials and reference measurement methods related to protein and nucleic acid of TM, as well as the problems existing in the international convention reference measurement procedure and traceability system of TM, so as to provide a new idea for the quality assurance work of TM detection.


Asunto(s)
Biomarcadores de Tumor , Técnicas de Laboratorio Clínico , Humanos , Estándares de Referencia , Reproducibilidad de los Resultados
3.
Int J Mol Sci ; 22(5)2021 Mar 04.
Artículo en Inglés | MEDLINE | ID: mdl-33806437

RESUMEN

Tiger nut (Cyperus esculentus), a perennial C4 plant of the Cyperaceae family, is an unconventional crop that is distinguished by its oil-rich tubers, which also possesses the advantages of strong resistance, wide adaptability, short life periods, and large biomass. To facilitate studies on gene expression in this species, we identified and validated a series of reference genes (RGs) based on transcriptome data, which can be employed as internal controls for qRT-PCR analysis in tiger nut. Fourteen putative candidate RGs were identified and evaluated across nine different tissues of two cultivars, and the RGs were analyzed using three different algorithms (geNorm, NormFinder, and BestKeeper). The stability rankings of the candidate RGs were merged into consensus lists with RankAggreg. For the below-ground storage organ of tiger nut, the optimal RGs were TUB4 and UCE2 in different developmental stages of tubers. UCE2 and UBL5 were the most stably expressed RGs among all tissues, while Rubisco and PGK exhibited the lowest expression stability. UCE2, UBL5 and Rubisco were compared to normalize the expression levels of the caleosin (CLO) and diacylglycerol acyltransferase 2-2 (DGAT2-2) genes across the same tissues. Our results showed that the RGs identified in this study, which exhibit more uniform expression patterns, may be utilized for the normalization of qRT-PCR results, promoting further research on gene expression in various tissues of tiger nut.


Asunto(s)
Cyperus/genética , Transcriptoma/genética , Proteínas de Unión al Calcio/genética , Cyperus/metabolismo , Perfilación de la Expresión Génica/métodos , Regulación de la Expresión Génica de las Plantas/genética , Aceites Vegetales/metabolismo , Proteínas de Plantas/genética , Tubérculos de la Planta/genética , Estándares de Referencia , Reacción en Cadena de la Polimerasa de Transcriptasa Inversa/métodos
4.
Nat Commun ; 12(1): 2177, 2021 04 12.
Artículo en Inglés | MEDLINE | ID: mdl-33846355

RESUMEN

The recent advancements in single-cell technologies, including single-cell chromatin accessibility sequencing (scCAS), have enabled profiling the epigenetic landscapes for thousands of individual cells. However, the characteristics of scCAS data, including high dimensionality, high degree of sparsity and high technical variation, make the computational analysis challenging. Reference-guided approaches, which utilize the information in existing datasets, may facilitate the analysis of scCAS data. Here, we present RA3 (Reference-guided Approach for the Analysis of single-cell chromatin Accessibility data), which utilizes the information in massive existing bulk chromatin accessibility and annotated scCAS data. RA3 simultaneously models (1) the shared biological variation among scCAS data and the reference data, and (2) the unique biological variation in scCAS data that identifies distinct subpopulations. We show that RA3 achieves superior performance when used on several scCAS datasets, and on references constructed using various approaches. Altogether, these analyses demonstrate the wide applicability of RA3 in analyzing scCAS data.


Asunto(s)
Epigénesis Genética , Análisis de la Célula Individual , Análisis por Conglomerados , Células HEK293 , Humanos , Estándares de Referencia
5.
Artículo en Inglés | MEDLINE | ID: mdl-33799987

RESUMEN

The purpose of this study was to establish consensus regarding a standardized approach to the diagnostic evaluation of ACL tears in pediatric/adolescent patients. Despite an abundance of literature evaluating management techniques, no standardized consensus exists regarding evaluation in these patients. A three-step classic Delphi technique was employed. The panel included 12 Orthopaedic Sports Medicine specialists from across the United States with training in pediatric and adult ACL injuries. Panelists were presented with four clinical vignettes. Consensus was established if ≥66% of respondents reached agreement. Across all four rounds of this study, 100% participation was achieved, and consensus was reached for a majority of diagnostic domains. For history, previous injuries, sports participation, and current symptoms were endorsed for all vignettes. The consensus radiographic sequences across all four vignettes included: standing AP, flexion (tunnel or notch view), lateral, long-leg alignment, and bone age (left hand) views. Radiographic interpretation responses met consensus with interpretations were split by gender. Cross-sectional imaging met consensus with 100% support for MRI. In this Delphi study, we identified a standardized diagnostic treatment approach derived from expert opinion applicable to all skeletally immature patients with ACL tears, which can serve as a framework for evaluation to aid clinical decision making.


Asunto(s)
Lesiones del Ligamento Cruzado Anterior , Reconstrucción del Ligamento Cruzado Anterior , Traumatismos en Atletas , Adolescente , Lesiones del Ligamento Cruzado Anterior/diagnóstico por imagen , Lesiones del Ligamento Cruzado Anterior/cirugía , Traumatismos en Atletas/diagnóstico por imagen , Niño , Humanos , Imagen por Resonancia Magnética , Estándares de Referencia
6.
Artículo en Inglés | MEDLINE | ID: mdl-33808743

RESUMEN

Effective cardiovascular disease (CVD) prevention relies on timely identification and intervention for individuals at risk. Conventional formula-based techniques have been demonstrated to over- or under-predict the risk of CVD in the Australian population. This study assessed the ability of machine learning models to predict CVD mortality risk in the Australian population and compare performance with the well-established Framingham model. Data is drawn from three Australian cohort studies: the North West Adelaide Health Study (NWAHS), the Australian Diabetes, Obesity, and Lifestyle study, and the Melbourne Collaborative Cohort Study (MCCS). Four machine learning models for predicting 15-year CVD mortality risk were developed and compared to the 2008 Framingham model. Machine learning models performed significantly better compared to the Framingham model when applied to the three Australian cohorts. Machine learning based models improved prediction by 2.7% to 5.2% across three Australian cohorts. In an aggregated cohort, machine learning models improved prediction by up to 5.1% (area-under-curve (AUC) 0.852, 95% CI 0.837-0.867). Net reclassification improvement (NRI) was up to 26% with machine learning models. Machine learning based models also showed improved performance when stratified by sex and diabetes status. Results suggest a potential for improving CVD risk prediction in the Australian population using machine learning models.


Asunto(s)
Enfermedades Cardiovasculares , Adulto , Australia/epidemiología , Enfermedades Cardiovasculares/epidemiología , Estudios de Cohortes , Humanos , Aprendizaje Automático , Estándares de Referencia , Medición de Riesgo , Factores de Riesgo
7.
J Korean Med Sci ; 36(14): e101, 2021 Apr 12.
Artículo en Inglés | MEDLINE | ID: mdl-33847084

RESUMEN

We evaluated the Standard Q COVID-19 Ag test for the diagnosis of coronavirus disease 2019 (COVID-19) compared to the reverse transcription-polymerase chain reaction (RT-PCR) test. We applied both tests to patients who were about to be hospitalized, had visited an emergency room, or had been admitted due to COVID-19 confirmed by RT-PCR. Two nasopharyngeal swabs were obtained; one was tested by RT-PCR and the other by the Standard Q COVID-19 Ag test. A total of 118 pairs of tests from 98 patients were performed between January 5 and 11, 2021. The overall sensitivity and specificity for detecting severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) for the Standard Q COVID-19 Ag test compared to RT-PCR were 17.5% (95% confidence interval [CI], 8.8-32.0%) and 100% (95% CI, 95.3-100.0%). Analysis of the results using RT-PCR cycle thresholds of ≤ 30 or ≤ 25 increased the sensitivity to 26.9% (95% CI, 13.7-46.1%), and 41.1% (95% CI, 21.6-64.0%), respectively.


Asunto(s)
Antígenos Virales/inmunología , /inmunología , Servicio de Urgencia en Hospital , Reacciones Falso Positivas , Humanos , Nasofaringe/virología , Valor Predictivo de las Pruebas , Probabilidad , Estándares de Referencia , Reproducibilidad de los Resultados , Reacción en Cadena de la Polimerasa de Transcriptasa Inversa , Sensibilidad y Especificidad
8.
Zhonghua Yi Xue Za Zhi ; 101(15): 1083-1087, 2021 Apr 20.
Artículo en Chino | MEDLINE | ID: mdl-33878836

RESUMEN

Objective: To compare the postoperative outcomes and urinary continence recovery time between standard robotic-assisted laparoscopic radical prostatectomy (RARP) and Retzius-sparing robotic-assisted laparoscopic radical prostatectomy (RsRARP). Methods: A total of 92 patients with low to intermediate-risk prostate cancer who underwent RARP (n=52) and RsRARP (n=40) in Sir Run Run Shaw Hospital from October, 2016 to January, 2018 were retrospectively reviewed. Perioperative data (operative time, estimated blood loss, complications, postoperative staging, postoperative Gleason score) and surgical outcomes (rate of margin positive, urinary continence recovery time) of RARP and RsRARP group were comparatively analyzed. Results: All 92 cases were successfully performed with robot. RARP group had a significantly shorter mean operative time when compared with that in RsRARP group ((103±23) min vs (130±26) min, P<0.05). The two groups had comparable estimated blood loss ((100±54) ml vs (103±64) ml, P>0.05), rate of postoperative infection (5.8% (3/52) vs 5.0% (2/40), P>0.05) and rate of postoperative urine leakage (3.8%(2/52) vs 2.5%(1/40), P>0.05). The two groups had a comparable rate of margin positive (7.7%(4/52) vs 12.5%(5/40), P>0.05). Compared with RsRARP group, the RARP group had a lower rate of urinary continence recovery immediately after the catheter removing at 1 week, 1 month and 3 months after the operation (all P>0.05). The two group had a comparable rate of urinary continence recovery at 6 months after the operation (P>0.05). Conclusion: The RsRARP technique has a good tumor control and obvious advantage of early urinary continence recovery compared with the standard RARP technique. RsRARP technique is safe and effective for the treatment of localized prostate cancer.


Asunto(s)
Laparoscopía , Neoplasias de la Próstata , Procedimientos Quirúrgicos Robotizados , Robótica , Humanos , Masculino , Complicaciones Posoperatorias/epidemiología , Prostatectomía , Neoplasias de la Próstata/cirugía , Recuperación de la Función , Estándares de Referencia , Estudios Retrospectivos , Resultado del Tratamiento
9.
Med Lav ; 112(2): 95-106, 2021 Apr 20.
Artículo en Inglés | MEDLINE | ID: mdl-33881003

RESUMEN

Spirometry is a commonly performed assessment of lung function for diagnostic purposes as well as for monitoring of chronic lung diseases. The last international standardization of this technique was published in 2005. After 14 years, a group of experts from two leading scientific societies, American Thoracic Society (ATS) and European Respiratory Society (ERS), published a joint position that updated the standardization of spirometry, with an extensive criteria re-organization, including key updates such as: relative contraindications, instrumentation requirement to meet the International Organization for Standardization (ISO) standards, quality assurance, operator training, pre-test requirements, acceptability and usability criteria. New standards underline three key elements to obtain high quality pulmonary function data: an accurate and precise instrumentation, a patient/subject capable of performing acceptable and repeatable measurements, and a motivated technologist to elicit maximum performance from the patient. Never- theless, although COVID-19 pandemic has enormously impacted and limited a widespread application of spirometry, it has prompted much attention on hygienic procedures and on further research on noncontact spirometers.


Asunto(s)
Salud Laboral , Humanos , Pandemias , Estándares de Referencia , Espirometría , Estados Unidos
10.
Zhongguo Zhen Jiu ; 41(4): 435-8, 2021 Apr 12.
Artículo en Chino | MEDLINE | ID: mdl-33909367

RESUMEN

To explore the problems and countermeasures existing in acupuncture and moxibustion clinical studies, in the perspective of the key steps of Guideline for Clinical Practice of Acupuncture and Moxibustion: Insomnia. The problems include: confusion of disease names and disunity of diagnostic criteria, inadequate refined clinical problems that need to be addressed, lack of targeted analysis of efficacy evaluation index, lack of adequate research on common acupuncture, difficulty to balance innovation and universality, lack of emphasis on the importance of timing for acupuncture, lack of attention to healthy lifestyles and self-care. We suggests that the disease name and diagnostic criteria should refer to the authoritative standards; the clinical study design should based on the realistic clinical problems; the efficacy evaluation index should based on the clinical needs and be analyzed targetedly; further research on common acupuncture or therapy should be carried out.


Asunto(s)
Terapia por Acupuntura , Acupuntura , Moxibustión , Trastornos del Inicio y del Mantenimiento del Sueño , Humanos , Estándares de Referencia , Trastornos del Inicio y del Mantenimiento del Sueño/terapia
11.
Zhongguo Zhen Jiu ; 41(4): 439-42, 2021 Apr 12.
Artículo en Chino | MEDLINE | ID: mdl-33909368

RESUMEN

This article introduces the present development status, medical insurance charges, publicity and influence, legislation and practice of acupuncture-moxibustion in Namibia, and proposes some countermeasures for the current problems in the development of acupuncture-moxibustion in Namibia. Namibia has passed legislation of acupuncture-moxibustion and incorporated acupuncture-moxibustion into the medical insurance system in March 2020. The acupuncture-moxibustion will enter the fast track of development, but the acupuncture-moxibustion education, training and cooperation, talent cultivation mode, reimbursement scope of medical insurance, and standardization construction still need to be steadily improved and strengthened.


Asunto(s)
Terapia por Acupuntura , Acupuntura , Moxibustión , Namibia , Estándares de Referencia
12.
Int J Mol Sci ; 22(5)2021 Mar 06.
Artículo en Inglés | MEDLINE | ID: mdl-33800950

RESUMEN

Male patients with Fabry disease (FD) are at high risk for the formation of antibodies to recombinant α-galactosidase A (AGAL), used for enzyme replacement therapy. Due to the rapid disease progression, the identification of patients at risk is highly warranted. However, currently suitable references and standardized protocols for anti-drug antibodies (ADA) determination do not exist. Here we generate a comprehensive patient-derived antibody mixture as a reference, allowing ELISA-based quantification of antibody titers from individual blood samples. Serum samples of 22 male patients with FD and ADAs against AGAL were pooled and purified by immune adsorption. ADA-affinities against agalsidase-α, agalsidase-ß and Moss-AGAL were measured by quartz crystal microbalance with dissipation monitoring (QCM-D). AGAL-specific immune adsorption generated a polyclonal ADA mixture showing a concentration-dependent binding and inhibition of AGAL. Titers in raw sera and from purified total IgGs (r2 = 0.9063 and r2 = 0.8952, both p < 0.0001) correlated with the individual inhibitory capacities of ADAs. QCM-D measurements demonstrated comparable affinities of the reference antibody for agalsidase-α, agalsidase-ß and Moss-AGAL (KD: 1.94 ± 0.11 µM, 2.46 ± 0.21 µM, and 1.33 ± 0.09 µM, respectively). The reference antibody allows the ELISA-based ADA titer determination and quantification of absolute concentrations. Furthermore, ADAs from patients with FD have comparable affinities to agalsidase-α, agalsidase-ß and Moss-AGAL.


Asunto(s)
Anticuerpos Neutralizantes/inmunología , Terapia de Reemplazo Enzimático , Ensayo de Inmunoadsorción Enzimática , Enfermedad de Fabry/inmunología , alfa-Galactosidasa/inmunología , alfa-N-Acetilgalactosaminidasa/inmunología , Anticuerpos Neutralizantes/biosíntesis , Afinidad de Anticuerpos , Relación Dosis-Respuesta Inmunológica , Enfermedad de Fabry/sangre , Enfermedad de Fabry/tratamiento farmacológico , Humanos , Inmunoglobulina G/biosíntesis , Inmunoglobulina G/inmunología , Masculino , Proteínas Recombinantes/inmunología , Proteínas Recombinantes/uso terapéutico , Estándares de Referencia , alfa-Galactosidasa/sangre , alfa-Galactosidasa/uso terapéutico , alfa-N-Acetilgalactosaminidasa/sangre , alfa-N-Acetilgalactosaminidasa/uso terapéutico
13.
Br J Radiol ; 94(1121): 20200685, 2021 May 01.
Artículo en Inglés | MEDLINE | ID: mdl-33861154

RESUMEN

OBJECTIVE: This study aims to determine if T1 relaxation time of the pancreas can detect parenchymal changes in early chronic pancreatitis (CP). METHODS: This study retrospectively analyzed 42 patients grouped as no CP (Cambridge 0; n = 21), equivocal (Cambridge 1; n = 12) or mild CP (Cambridge 2; n = 9) based on magnetic resonance cholangiopancreatography findings using the Cambridge classification as the reference standard. Unenhanced T1 maps were acquired using a three-dimensional dual flip-angle gradient-echo technique on the same 1.5 T scanner with the same imaging parameters. RESULTS: There was no significant difference between the T1 relaxation times of Cambridge 0 and 1 group (p = 0.58). There was a significant difference (p = 0.0003) in the mean T1 relaxation times of the pancreas between the combined Cambridge 0 and 1 (mean = 639 msec, 95% CI: 617, 660) and Cambridge 2 groups (mean = 726 msec, 95% CI: 692, 759). There was significant difference (p = 0.0009) in the mean T1 relaxation times of the pancreas between the Cambridge 0 (mean = 636 msec, 95% CI: 606, 666) and Cambridge 2 groups (mean = 726 msec, 95% CI: 692,759) as well as between Cambridge 1 (mean = 643 msec, 95% CI: 608, 679) and Cambridge 2 groups (mean = 726 msec, 95% CI: 692,759) (p = 0.0017). Bland-Altman analysis showed measurements of one reader to be marginally higher than the other by 15.7 msec (2.4%, p = 0.04). CONCLUSION: T1 mapping is a practical method capable of quantitatively reflecting morphologic changes even in the early stages of chronic pancreatitis, and demonstrates promise for future implementation in routine clinical imaging protocols. ADVANCES IN KNOWLEDGE: T1 mapping can distinguish subtle parenchymal changes seen in early stage CP, and demonstrates promise for implementation in routine imaging protocols for the diagnosis of CP.


Asunto(s)
Pancreatocolangiografía por Resonancia Magnética/métodos , Imagenología Tridimensional/métodos , Páncreas/diagnóstico por imagen , Conductos Pancreáticos/diagnóstico por imagen , Pancreatitis Crónica/diagnóstico por imagen , Adulto , Anciano , Femenino , Humanos , Masculino , Persona de Mediana Edad , Páncreas/patología , Conductos Pancreáticos/patología , Pancreatitis Crónica/clasificación , Pancreatitis Crónica/patología , Estándares de Referencia , Estudios Retrospectivos , Factores de Tiempo , Adulto Joven
14.
Indian J Med Ethics ; VI(2): 1-7, 2021.
Artículo en Inglés | MEDLINE | ID: mdl-33908355

RESUMEN

It is fair to say that nothing is more pressing in today's world than bringing an end to the Covid-19 pandemic. Or to be more precise, if not an end, then the quickest and most effective reduction of mortality and morbidity from the disease in every country where infections exist. The forthcoming theme issue of IJME explores a long-standing ethical concern in research with human beings, focused mainly on a question posed about vaccine research for prevention of Covid-19. Contributors from six continents address the question: In what circumstances - if any ‒ is it ethically acceptable to use a research design in which the control group in a randomised, controlled trial (RCT) receives a placebo instead of a vaccine already approved for emergency use by regulatory bodies? That ethical question is not new.


Asunto(s)
Vacunas , Humanos , Pandemias , Estándares de Referencia
15.
Zhongguo Yi Liao Qi Xie Za Zhi ; 45(2): 194-199, 2021 Apr 08.
Artículo en Chino | MEDLINE | ID: mdl-33825381

RESUMEN

OBJECTIVE: To understand the current situation of artificial intelligence production enterprise quality management system, so as to provide reference basis for the research and standardization of Artificial Intelligence Medical Device (AIMD) product quality management. METHODS: Based on YY/T 0287-2017 Medical Device Quality Management System for Regulatory Requirements, Medical Equipment Production and the Quality Control Standard for Independent Software Appendix and Xavier GMLP report, the relevant factors were screened and the questionnaire was designed by combining expert consultation and literature review. Then, a total of 32 representative AIMD enterprises were invited to fill in the questionnaire. Descriptive statistical analysis was performed on the data results using Excel 2016. RESULTS: Through in-depth analysis of the four themes in product planning and design, result output, product quality control and product change, it was found that it was necessary for enterprises participating in the survey to improve the quality management system of AIMD products to different degrees. CONCLUSIONS: This study is the first time to systematically investigate the status quo of quality management of AIMD enterprises. The result will be useful for the establishment and continuous improvement of product quality management system. It will also provide a reference for the research of AIMD product quality management and the establishment of the standard.


Asunto(s)
Inteligencia Artificial , Programas Informáticos , Control de Calidad , Estándares de Referencia
16.
Zhongguo Yi Liao Qi Xie Za Zhi ; 45(2): 205-209, 2021 Apr 08.
Artículo en Chino | MEDLINE | ID: mdl-33825383

RESUMEN

The registration system of medical device Master Files is established to solve the problem that the outsourcing suppliers are not willing to cooperate with the device applicants in the process of providing medical device application documents. After a brief introduction of Master Files systems established by foreign regulatory agencies, this article focuses on the research of establishing a medical device Master Files registration system in China. The results show that the establishment of Chinese Master Files registration system can both improve the standardization and convenience of outsourcing activities of medical devices, and satisfy the needs of the development of medical device industry and regulatory system. At the same time, the probability of additional risk caused by the implementation of the system is low. Therefore, it is expected that the benefits of the system to promote public health outweigh the potential risks, which demonstrates that establishment of the system has important application values.


Asunto(s)
Industrias , China , Estándares de Referencia
18.
Anticancer Res ; 41(4): 1909-1920, 2021 Apr.
Artículo en Inglés | MEDLINE | ID: mdl-33813396

RESUMEN

BACKGROUND/AIM: This comparative plan study examines a range of boost-radiation methods in adjuvant radiotherapy of breast cancer using helical intensity-modulated radiotherapy with TomoEdge-technique. Impact of hypofractionated radiation with simultaneous-integrated boost (SIB) and influence of differing assumed α/ß-values were examined. PATIENTS AND METHODS: For 10 patients with left-sided breast cancer each four helical IMRT-plans with TomoEdge-technique were created: hypofractionated+SIB (H-SIB) (42.4/54.4 Gy, 16 fractions), normofractionated+SIB (N-SIB) (50.4/64.4 Gy, 28 fractions), hypofractionated+sequential-boost (H-SB) (42.4 Gy/16 fractions+16 Gy/8 fractions), normofractionated+ sequential-boost (N-SB) (50.4 Gy/28 fractions+16 Gy/8 fractions). Equivalent doses (EQD2) to organs-at-risk (OAR) and irradiated mammary-gland were analysed for different assumed α/ß-values. RESULTS: The mean EQD2 to OAR was significantly lower using hypofractionated radiation-techniques. H-SIB and H-SB were not significantly different. H-SIB and N-SIB conformed significantly better to the breast planning-target volume (PTV) and boost-volume (BV) than H-SB and N-SB. Regarding BV, mean EQD2 was significantly higher for all α/ß-values investigated when using H-SIB and N-SIB. Regarding PTV, there were no clinically relevant differences. CONCLUSION: Relating to dosimetry, H-SIB is effective compared to standard-boost-techniques.


Asunto(s)
Neoplasias de la Mama/radioterapia , Neoplasias de la Mama/cirugía , Hipofraccionamiento de la Dosis de Radiación , Planificación de la Radioterapia Asistida por Computador , Radioterapia de Intensidad Modulada , Adulto , Neoplasias de la Mama/patología , Femenino , Corazón/efectos de la radiación , Humanos , Pulmón/efectos de la radiación , Mastectomía Segmentaria/métodos , Órganos en Riesgo , Hipofraccionamiento de la Dosis de Radiación/normas , Planificación de la Radioterapia Asistida por Computador/métodos , Planificación de la Radioterapia Asistida por Computador/normas , Radioterapia Ayuvante/efectos adversos , Radioterapia Ayuvante/métodos , Radioterapia Ayuvante/normas , Radioterapia de Intensidad Modulada/efectos adversos , Radioterapia de Intensidad Modulada/métodos , Radioterapia de Intensidad Modulada/normas , Estándares de Referencia , Carga Tumoral/efectos de la radiación
19.
Pol Merkur Lekarski ; 49(290): 114-118, 2021 Apr 18.
Artículo en Inglés | MEDLINE | ID: mdl-33895756

RESUMEN

Prophylactic medical examinations - called well-child visit - are among the benefits guaranteed under basic health care. The prophylactic visit should include, among others: physical examination and an interview (with the adolescent and the parent), as well as individual pro-health education. AIM: The aim of the study was to answer the question whether preventive medical visits of 15/16 year olds from the Warsaw Agglomeration are carried out within the scope defined by the Minister of Health and in accordance with standards. MATERIALS AND METHODS: The course of well-child visit was evaluated on the basis of 359 anonymous questionnaires filled in by students from randomly selected 11 schools from the Warsaw Agglomeration. RESULTS: In 3.3% of the respondents, the doctor did not carry out any of the physical examinations asked in the questionnaire. The most often doctor auscultated chest organs (94.4% of respondents), the least frequently examined genitals in girls (2.1%). During the visit, the doctors raised less than 4 topics on average. The most frequent subjects of discussion were menstruation (80.0% of girls), chronic diseases in the adolescent's family (59.1%) and physical activity (51.0%); the rarest ones were depression and suicidal thoughts (3.1%), violence (1.9%) and the influence of the family on the patient's well-being (1.4%). The compatibility of the gender of the patient and the doctor increased the number of topics discussed. CONCLUSIONS: The confrontation of the data obtained by us with the content of the Minister of Health's regulation and the standards in force in Poland provides the basis for a negative assessment of the implementation of medical prophylactic examinations in the adolescents in the Warsaw Agglomeration.


Asunto(s)
Médicos , Adolescente , Niño , Enfermedad Crónica , Femenino , Humanos , Polonia , Estándares de Referencia , Encuestas y Cuestionarios
20.
Sensors (Basel) ; 21(5)2021 Mar 03.
Artículo en Inglés | MEDLINE | ID: mdl-33802495

RESUMEN

Over the last few years, the Leap Motion Controller™ (LMC) has been increasingly used in clinical environments to track hand, wrist and forearm positions as an alternative to the gold-standard motion capture systems. Since the LMC is marker-less, portable, easy-to-use and low-cost, it is rapidly being adopted in healthcare services. This paper demonstrates the comparison of finger kinematic data between the LMC and a gold-standard marker-based motion capture system, Qualisys Track Manager (QTM). Both systems were time synchronised, and the participants performed abduction/adduction of the thumb and flexion/extension movements of all fingers. The LMC and QTM were compared in both static measuring finger segment lengths and dynamic flexion movements of all fingers. A Bland-Altman plot was used to demonstrate the performance of the LMC versus QTM with Pearson's correlation (r) to demonstrate trends in the data. Only the proximal interphalangeal joint (PIP) joint of the middle and ring finger during flexion/extension demonstrated acceptable agreement (r = 0.9062; r = 0.8978), but with a high mean bias. In conclusion, the study shows that currently, the LMC is not suitable to replace gold-standard motion capture systems in clinical settings. Further studies should be conducted to validate the performance of the LMC as it is updated and upgraded.


Asunto(s)
Mano , Articulación de la Muñeca , Fenómenos Biomecánicos , Articulaciones de los Dedos , Dedos , Humanos , Movimiento (Física) , Rango del Movimiento Articular , Estándares de Referencia
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