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1.
Quintessence Int ; 51(2): 100-107, 2020.
Artículo en Inglés | MEDLINE | ID: mdl-31942571

RESUMEN

OBJECTIVE: The purpose of the present study was to assess the influence of type 2 diabetes mellitus (DM) on the evolution of pulpal and periapical pathology. METHOD AND MATERIALS: Two reviewers independently conducted a systematic search for articles published between 1 January 2001 and 31 December 2018 on MEDLINE/PubMed, ISI Web of Science, and Scopus databases. An additional manual search was also carried out. RESULTS: Ten studies fulfilling the inclusion criteria were included in the review (two longitudinal studies with 1-year follow-up comparing the success of primary root canal treatment between type 2 diabetic patients and non-diabetic patients, and eight cross-sectional studies). Analysis of the ten studies showed that inadequate control of type 2 DM may predispose and influence the inflammatory pulpal and periapical disease evolution. CONCLUSIONS: The present systematic review suggests that there are biologic bases to suggest that type 2 DM may act as a risk factor for developing an endodontic pathology, affecting the course of the disease in terms of susceptibility, prevalence, progression, and tissue healing capacity as a consequence of a disrupted immune response. However, more well-designed clinical investigations carrying out suitable research methodologies are needed to elucidate the influence of type 2 DM on the pulpal and periapical disease evolution.


Asunto(s)
Diabetes Mellitus Tipo 2 , Enfermedades Periapicales , Estudios Transversales , Humanos , Estudios Longitudinales , Tratamiento del Conducto Radicular
2.
Rev Med Liege ; 75(1): 37-42, 2020 Jan.
Artículo en Francés | MEDLINE | ID: mdl-31920042

RESUMEN

OBJECTIVE: Perfluoroalkyl substances (PFAS) are chemicals widely employed in the industry. Long term consequences of the newborns' contamination by PFAS on thyroid function are of concern. The aim of this study is to assess the potential associations between PFAS contamination measured at birth and thyroid function assessed few months later. PFAS levels were previously determined in cord blood from a cohort of newborns recruited in Liege. METHOD: Parents of the children belonging to the first and the fifth quintiles of exposure to PFAS were contacted in order to measure the thyroid stimulating hormone (TSH) levels in their child few months after birth. Twenty-eight children participated in the study. Moreover, we performed a literature review about associations between pre- or perinatal exposure to persistent organic pollutants and thyroid function during early childhood. RESULT: No significant difference was highlighted between both groups of contamination (Mann-Whitney, p-value = 0.91). Literature review highlighted the critical need of new longitudinal data about this problematic. CONCLUSION: Our results suggest that the PFAS levels at birth are not associated with TSH levels later in life. Large scale studies are required to confirm our results.


Asunto(s)
Contaminantes Ambientales , Fluorocarburos , Enfermedades de la Tiroides , Glándula Tiroides , Niño , Estudios de Cohortes , Femenino , Humanos , Recién Nacido , Estudios Longitudinales , Embarazo , Enfermedades de la Tiroides/epidemiología , Glándula Tiroides/fisiopatología
3.
Medicine (Baltimore) ; 99(1): e18461, 2020 Jan.
Artículo en Inglés | MEDLINE | ID: mdl-31895777

RESUMEN

This study was conducted to examine the effect of protective factors on the relationship between crisis episodes and depression in the elderly population in Taiwan.In this study, the Taiwan Longitudinal Study on Aging was used as basis for a cross-sectional secondary data analysis. After eliminating respondents below the age of 65 years and those with missing values, 2426 samples were collected. Predictive variables, such as crisis episodes, personal resources, family ties, social participation, and social support, were investigated, and the dependent variable of "depression status" was measured using the Center for Epidemiologic Studies Depression scale.According to the results of regression analysis, the protective factors of self-assessed health (ß = -0.290, P < .001), instrumental support (ß = -0.153, P < .001), financial satisfaction (ß = -0.126, P < .001), emotional support (ß = -0.101, P < .001), crisis episodes (ß = 0.087, P < .001), support satisfaction (ß = -0.081, P < .001), leisure participation (ß = -0.053, P < .05), family ties (ß = -0.048, P < .05), and community participation (ß = -0.042, P < .05) had a significant effect on depression status. Moreover, leisure participation had a moderating effect on the relationship between crisis episodes and depression (ß = -0.07, P < .01). In addition, according to path analysis results, family ties had a significant negative predictive power on depression (ß = -0.225, P < .001), as did social support (ß = -0.978, P < .001). The predictive power of crisis episodes on depression through social support was 0.197 (-0.201 × -0.978 = 0.197, P < .001), and it was -0.324 (-0.331 × -0.978 = -0.324, P < .001) through social participation, which indicated that social support plays a mediating role between crisis episodes and depression and between social participation and depression.Strengthening effective protective factors can improve the resilience of elderly people and enable them to cope with dilemmas rapidly and effectively when faced with crisis episodes as well as restore their health status and enjoy a satisfactory life.


Asunto(s)
Depresión/epidemiología , Resiliencia Psicológica , Índice de Severidad de la Enfermedad , Anciano , Anciano de 80 o más Años , Estudios Transversales , Depresión/diagnóstico , Progresión de la Enfermedad , Femenino , Humanos , Estudios Longitudinales , Masculino , Factores Protectores , Apoyo Social , Taiwán/epidemiología
4.
Sci Total Environ ; 699: 134365, 2020 Jan 10.
Artículo en Inglés | MEDLINE | ID: mdl-31677459

RESUMEN

Methane production from microalgae can be enhanced through anaerobic co-digestion with carbon-rich substrates and thus mitigate the inhibition risk associated with its low C:N ratio. Acclimated microbial communities for microalgae disruption can be used as a source of natural enzymes in bioenergy production. However, co-substrates with a certain microbial diversity such as primary sludge might shift the microbial structure. Substrates were generated in a Water Resource Recovery Facility (WRRF) and combined as follows: Scenedesmus or Chlorella digestion and microalgae co-digestion with primary sludge. The study was performed using two lab-scale Anaerobic Membrane Bioreactors (AnMBR). During three years, different feedstocks scenarios for methane production were evaluated with a special focus on the microbial diversity of the AnMBR. 57% of the population was shared between the different feedstock scenarios, revealing the importance of Anaerolineaceae members besides Smithella and Methanosaeta genera. The addition of primary sludge enhanced the microbial diversity of the system during both Chlorella and Scenedesmus co-digestion and promoted different microbial structures. Aceticlastic methanogen Methanosaeta was dominant in all the feedstock scenarios. A more remarkable role of syntrophic fatty acid degraders (Smithella, Syntrophobacteraceae) was observed during co-digestion when only microalgae were digested. However, no significant changes were observed in the microbial composition during anaerobic microalgae digestion when feeding only Chlorella or Scenedesmus. This is the first work revealing the composition of complex communities for semi-continuous bioenergy production from WRRF streams. The stability and maintenance of a microbial core over-time in semi-continuous AnMBRs is here shown supporting their future application in full-scale systems for raw microalgae digestion or co-digestion.


Asunto(s)
Microalgas , Eliminación de Residuos Líquidos/métodos , Biocombustibles , Reactores Biológicos , Chlorella , Estudios Longitudinales , Microbiota , Scenedesmus
5.
J Urol ; 203(1): 128-136, 2020 01.
Artículo en Inglés | MEDLINE | ID: mdl-31361571

RESUMEN

PURPOSE: To our knowledge it is unknown whether stereotactic body radiation therapy of prostate cancer is a substitute for other radiation treatments or surgery, or for expanding the pool of patients who undergo treatment instead of active surveillance. MATERIALS AND METHODS: Using SEER (Surveillance, Epidemiology, and End Results)-Medicare we identified men diagnosed with prostate cancer between 2007 and 2011. We developed physician-hospital networks by identifying the treating physician of each patient based on the primary treatment received and subsequently assigning each physician to a hospital. We examined the relative distribution of prostate cancer treatments stratified by whether stereotactic body radiation therapy was performed in a network by fitting logistic regression models with robust SEs to account for patient clustering in networks. RESULTS: We identified 344 physician-hospital networks, including 30 (8.7%) and 314 (91.3%) in which stereotactic body radiation therapy was and was not performed, respectively. Networks in which that therapy was and was not done did not differ with time in the performance of robotic and radical prostatectomy, and active surveillance (all p >0.05). The relationship with intensity modulated radiation therapy did not show any consistent temporal pattern. In networks in which it was performed less intensity modulated radiation therapy was initially done but there were similar rates in later years. Brachytherapy trends differed among networks in which stereotactic body radiation therapy was vs was not performed with a lower brachytherapy rate in networks in which stereotactic body radiation therapy was done (p=0.03). CONCLUSIONS: Surgery and active surveillance rates did not differ in networks in which stereotactic body radiation therapy was vs was not performed but when that therapy was done there was a lower brachytherapy rate. Stereotactic body radiation therapy may represent more of an alternative to brachytherapy than to active surveillance.


Asunto(s)
Pautas de la Práctica en Medicina/estadística & datos numéricos , Neoplasias de la Próstata/radioterapia , Radiocirugia , Anciano , Humanos , Estudios Longitudinales , Masculino , Programa de VERF , Estados Unidos
6.
J Urol ; 203(1): 171-178, 2020 01.
Artículo en Inglés | MEDLINE | ID: mdl-31430232

RESUMEN

PURPOSE: Our current understanding of recent trends in the management of lower urinary tract symptoms associated with benign prostatic hyperplasia is incomplete, particularly in younger men. The 2018 Urologic Diseases in America Project attempted to fill this gap by analyzing multiple large administrative claims databases which include men of all ages and permit longitudinal followup. To our knowledge we report these findings for the first time in the scientific literature. MATERIALS AND METHODS: The 2 data sources used in this study included the de-identified Optum® Clinformatics® Data Mart database for men 40 to 64 years old and the Medicare 5% Sample for men 65 years old or older. To assess trends in lower urinary tract symptoms/benign prostatic hyperplasia related medication prescriptions and surgical procedures from 2004 to 2013 we created annual cross-sectional cohorts and a longitudinal cohort of patients with incident lower urinary tract symptoms/benign prostatic hyperplasia and 5 years of followup. RESULTS: The use of medications related to lower urinary tract symptoms/benign prostatic hyperplasia increased with age, particularly among men 40 to 60 years old. While medication use increased with time, surgical procedures decreased. Increasing age correlated with a higher rate of surgical procedures in the longitudinal cohort. Younger men were more likely to elect treatments of lower urinary tract symptoms/benign prostatic hyperplasia which reportedly optimize sexual function. CONCLUSIONS: Medication use increased and surgery decreased during the study period. Treatment approaches to lower urinary tract symptoms/benign prostatic hyperplasia varied greatly by patient age. While the minority of men in the fifth and sixth decades of life required treatment, a sharp increase in treatment use was seen between these decades. Younger men were more likely to elect less invasive surgical options. Future studies of lower urinary tract symptoms/benign prostatic hyperplasia should focus on age specific treatment selection.


Asunto(s)
Síntomas del Sistema Urinario Inferior/etiología , Hiperplasia Prostática/complicaciones , Adulto , Factores de Edad , Anciano , Estudios Transversales , Humanos , Estudios Longitudinales , Síntomas del Sistema Urinario Inferior/tratamiento farmacológico , Síntomas del Sistema Urinario Inferior/cirugía , Masculino , Medicare , Persona de Mediana Edad , Hiperplasia Prostática/tratamiento farmacológico , Hiperplasia Prostática/cirugía , Estados Unidos
7.
J Urol ; 203(1): 159-163, 2020 01.
Artículo en Inglés | MEDLINE | ID: mdl-31441673

RESUMEN

PURPOSE: Patients who undergo cystectomy due to bladder cancer can elect an ileal conduit or a neobladder for urinary diversion. Decision regret related to this choice is an important and undesirable patient reported outcome. Our objective was to compare the severity of decision regret experienced by patients with a neobladder vs an ileal conduit. MATERIALS AND METHODS: We analyzed data from a longitudinal cohort study of patients who underwent cystectomy from 2013 to 2015. We applied multivariable linear regression to examine associations of the urinary diversion method (neobladder vs ileal conduit) with decision regret measured with the DRS (Decision Regret Scale) 6 and 18 months after cystectomy. Covariates included demographic and clinical characteristics, health care utilization and complications after cystectomy, quality of life and factors related to the decision making process, including informed and shared decision making, and goal concordance. RESULTS: Of the 192 patients in our cohort 141 received an ileal conduit and 51 received a neobladder. We observed no significant difference in the DRS score in patients with a neobladder vs an ileal conduit at 6 or 18 months (b=-1.28, 95% CI -9.07-6.53, vs b=-1.55, 95% CI -12.48-9.38). However, informed decision making was negatively related to decision regret at 6 and 18 months (b=-13.08, 95% CI -17.05--9.11, and b=-8.54, 95% CI -4.26--2.63, respectively). Quality of life was negatively associated with decision regret at 18 months (b=-5.50, 95% CI -8.95--2.03). CONCLUSIONS: Patients treated with cystectomy who were more informed about bladder reconstruction options experienced less regret independent of the method selected. Efforts to inform and prepare patients for the bladder reconstruction decision may help prevent decision regret.


Asunto(s)
Cistectomía , Toma de Decisiones , Neoplasias de la Vejiga Urinaria/cirugía , Derivación Urinaria/métodos , Femenino , Humanos , Estudios Longitudinales , Masculino , Persona de Mediana Edad , Invasividad Neoplásica , Medición de Resultados Informados por el Paciente , Satisfacción del Paciente , Calidad de Vida , Neoplasias de la Vejiga Urinaria/patología
8.
J Sci Food Agric ; 100(2): 714-720, 2020 Jan 30.
Artículo en Inglés | MEDLINE | ID: mdl-31597200

RESUMEN

BACKGROUND: Longitudinal data analysis contributes to detect differences in the growing curve by exploiting all the information involved in repeated measurements, allowing to distinguish changes over time within individuals, from differences in the baseline levels among groups. In this research, longitudinal and cross-sectional analysis were compared to evaluate differences in growth in Angus heifers under two different grazing conditions, ad libitum (AG) and controlled (CG) to gain 0.5 kg day-1 . RESULTS: Longitudinal mixed models show differences in growing curve parameters between grazing conditions, that were not detected by cross-sectional analysis. Differences (P < 0.05) in first derivative of growth curves (daily gain) until 289 days were observed between treatments, AG being higher than CG. Correspondingly, pubertal heifer proportion was also higher in AG at the end of rearing (AG, 0.94; CG, 0.67). CONCLUSION: In longitudinal studies, the power to detect differences between groups increases by exploiting the whole information of repeated measures, modelling the relation between measurements performed on the same individual. Under a proper analysis, valid conclusion can be drawn with fewer animals in the trial, improving animal welfare and reducing investigation costs. © 2019 Society of Chemical Industry.


Asunto(s)
Alimentación Animal/análisis , Bovinos/crecimiento & desarrollo , Bovinos/metabolismo , Crianza de Animales Domésticos , Animales , Cruzamiento , Bovinos/genética , Estudios Transversales , Análisis de Datos , Conducta Alimentaria , Femenino , Estudios Longitudinales , Masculino , Poaceae/metabolismo
11.
Rev. cuba. angiol. cir. vasc ; 20(2)jul.-dic. 2019. tab
Artículo en Español | LILACS | ID: biblio-1003857

RESUMEN

Introducción: El pie diabético isquémico y la enfermedad arterial periférica, son dos enfermedades que ocasionan dolor por isquemia crítica y ponen en peligro la viabilidad de las extremidades inferiores. Objetivo: Demostrar la efectividad de la terapia regenerativa con plasma rico en plaquetas en pacientes con las enfermedades citadas. Métodos: Estudio longitudinal, prospectivo y aleatorizado realizado en el Servicio de Angiología del Hospital: Julio Trigo López, entre enero 2016-diciembre 2017. Se incluyeron 26 pacientes en dos grupos de estudios, 10 pacientes no diabéticos con claudicación intermitente y 16 pacientes con lesiones isquémicas en el pie del diabético. Se aplicó plasma rico en plaquetas por vía intramuscular en la pierna afectada, en el primer grupo y de forma intra- y perilesional en el pie del diabético isquémico. Resultados: Se obtuvo alivio del dolor y mejoría en más del 70 por ciento de los pacientes en la distancia de claudicación por encima o cerca de los 200 metros. En los pacientes con pie diabético isquémico, alivio del dolor y cierre de las lesiones isquémicas en el 81,3 por ciento, solo 3 pacientes requirieron amputaciones mayores de los miembros inferiores. Conclusiones: La terapia regenerativa resulta efectiva en el salvataje de las extremidades inferiores en los pacientes estudiados, asociada a los procedimientos convencionales empleados en la cirugía revascularizadora; disminuye la amputación mayor de miembros inferiores y es una posibilidad terapéutica más en manos de especialistas entrenados, por su impacto social y en la calidad de vida de pacientes y familiares(AU)


Introduction: Ischemic diabetic foot and peripheral arterial disease are two conditions that cause pain and put in danger the functionality of lower limbs. Objective: To demonstrate the effectiveness of regenerative therapy with platelet-rich plasma in patients with the above mentioned diseases. Methods: Longitudinal, prospective and randomized study that was conducted in the Angiology Service of Julio Trigo López Hospital, from January 2016 to December 2017. There were 26 patients included in 2 groups: 10 non-diabetic patients with intermittent claudication and 16 patients with ischemic lesions in the diabetic foot. Platelet-rich plasma was used instramuscularly in an affected legs of the first group, and intraperilesional and perilesional in the diabetic foot. Results: There was pain relief and improvement in more than 70 percent of patients in the claudication distance higher or near to 200 meters. In the patients presenting ischemic diabetic foot, pain relief and closing of ischemic lesions in the 81,3 percent , just 3 patients required major amputations of lower limbs. Conclusions: Regenerative therapy results effective in the rescue of lower limbs in patients presenting peripheral arterial disease and ischemic diabetic foot. It also reduces major amputations of lower limbs and it is another therapeutic option in the hands of trained specialists due to its social impact and in the life quality of patients and their families(AU)


Asunto(s)
Humanos , Masculino , Femenino , Plasma Rico en Plaquetas , Enfermedad Arterial Periférica/terapia , Proloterapia/métodos , Estudios Prospectivos , Estudios Longitudinales , Cuba
12.
Rev. cuba. angiol. cir. vasc ; 20(2): e387, jul.-dic. 2019.
Artículo en Español | LILACS | ID: biblio-1003855

RESUMEN

Introducción: Los pacientes con enfermedad arterial periférica sometidos a cirugía vascular no cardíaca programada presentan un riesgo significativo de complicaciones cardiovasculares, debido a la enfermedad cardíaca sintomática o asintomática subyacente. Objetivo: Valorar el riesgo coronario en los pacientes tributarios de cirugía vascular no cardíaca. Métodos: Estudio descriptivo prospectivo en 35 pacientes del Servicio de Angiología y Cirugía Vascular del Hospital Clínico Quirúrgico Hermanos Ameijeiras. El período de estudio osciló entre octubre de 2013 y mayo de 2016. Las variables cualitativas se expresaron como frecuencias absolutas y relativas. Se evaluó la asociación entre las variables mediante el test de Fischer, se usó el coeficiente de Pearson para relacionar los valores del índice de presiones tobillo brazo y los niveles del calcio score. Resultados: Predominó el sexo masculino y la edad menor de 60 años. El tabaquismo y la hipertensión arterial fueron los factores de riesgo de mayor frecuencia. A pesar de no existir diferencia significativa (p = 0,563) al asociar el calcio score y el índice de presiones tobillo-brazo, sí existió una correlación lineal negativa entre ellos. Las complicaciones perioperatorias presentadas en el grupo de moderado-alto riesgo quirúrgico fueron la fibrilación ventricular, el infarto agudo de miocardio y el paro cardíaco. Conclusiones: La valoración del riesgo coronario es una herramienta útil en la detección de lesiones coronarias significativas que pueden favorecer la aparición de complicaciones perioperatorias en los pacientes que son tributarios de tratamiento quirúrgico revascularizador no cardíaco(AU)


Introduction: Patients with peripheral arterial disease undergoing scheduled non-cardiac vascular surgery present a significant risk of cardiovascular complications due to underlying symptomatic or asymptomatic heart disease. Objective: To assess coronary risk in patients eligible for non-cardiac vascular surgery. Methods: A prospective descriptive study was carried out in 35 patients of the Angiology and Vascular Surgery service in Hermanos Ameijeiras Hospital. The study was conducted between October 2013 and May 2016. Qualitative variables were summarized as absolute and relative frequencies. It was assessed the association between the variables using the Fischer´s test; Pearson´s coefficient was used to relate the values of the index of ankle- arm pressure and the levels of calcium score. Results: Male sex predominated; and ages less than 60 years. Smoking habit and high blood pressure were the most common risk factors. Although there is no significant difference (p= 0,563) when associating the calcium score and the ankle-brachial pressure index, there was a negative linear correlation between them. The peri-operative complications presented in the moderate to high surgical risk group were ventricular fibrillation, acute myocardial infarction and cardiac arrest. Conclusions: Identification of coronary risk is a useful tool in the detection of significant coronary lesions that may favor the emergence of peri-operative complications in patients who are scheduled for non-cardiac revascularization's surgical treatment(AU)


Asunto(s)
Masculino , Persona de Mediana Edad , Enfermedades Cardiovasculares/prevención & control , Enfermedad Arterial Periférica/complicaciones , Epidemiología Descriptiva , Estudios Prospectivos , Estudios Longitudinales , Enfermedad Arterial Periférica/terapia
13.
BMJ ; 367: l6377, 2019 12 18.
Artículo en Inglés | MEDLINE | ID: mdl-31852659

RESUMEN

OBJECTIVE: To explore associations between different frequencies of arts engagement and mortality over a 14 year follow-up period. DESIGN: Prospective cohort study. PARTICIPANTS: English Longitudinal Study of Ageing cohort of 6710 community dwelling adults aged 50 years and older (53.6% women, average age 65.9 years, standard deviation 9.4) who provided baseline data in 2004-05. INTERVENTION: Self reported receptive arts engagement (going to museums, art galleries, exhibitions, the theatre, concerts, or the opera). MEASUREMENT: Mortality measured through data linkage to the National Health Service central register. RESULTS: People who engaged with receptive arts activities on an infrequent basis (once or twice a year) had a 14% lower risk of dying at any point during the follow-up (809/3042 deaths, hazard ratio 0.86, 95% confidence interval 0.77 to 0.96) compared with those who never engaged (837/1762 deaths). People who engaged with receptive arts activities on a frequent basis (every few months or more) had a 31% lower risk of dying (355/1906 deaths, 0.69, 0.59 to 0.80), independent of demographic, socioeconomic, health related, behavioural, and social factors. Results were robust to a range of sensitivity analyses with no evidence of moderation by sex, socioeconomic status, or social factors. This study was observational and so causality cannot be assumed. CONCLUSIONS: Receptive arts engagement could have a protective association with longevity in older adults. This association might be partly explained by differences in cognition, mental health, and physical activity among those who do and do not engage in the arts, but remains even when the model is adjusted for these factors.


Asunto(s)
Arte , Participación de la Comunidad/estadística & datos numéricos , Mortalidad/tendencias , Anciano , Cognición , Inglaterra/epidemiología , Ejercicio , Femenino , Estudios de Seguimiento , Conductas Relacionadas con la Salud , Humanos , Longevidad , Estudios Longitudinales , Masculino , Salud Mental , Persona de Mediana Edad , Modelos de Riesgos Proporcionales , Estudios Prospectivos , Medicina Estatal
14.
BMJ ; 367: l6058, 2019 12 18.
Artículo en Inglés | MEDLINE | ID: mdl-31852664

RESUMEN

OBJECTIVES: To evaluate the associations between birth month, birth season, and overall and cardiovascular disease mortality, and to examine the role of familial and socioeconomic factors in these associations. DESIGN: Prospective cohort study. SETTING: Nurses' Health Study, established in 1976, an ongoing prospective cohort study in the United States. PARTICIPANTS: Female registered nurses who reported information on date of birth at study enrolment (n=116 911, 1976-2014, followed for 38 years). EXPOSURE: Birth month and astronomical birth season (based on solstices and equinoxes as boundaries of the season categories). MAIN OUTCOME MEASURES: Age and various multivariable adjusted hazard ratios and 95% confidence intervals for the association between birth months (using November as the reference), astronomical birth season (using autumn as the reference), and overall and cardiovascular disease specific mortality were assessed using Cox proportional hazards models. RESULTS: Among study participants, 43 248 overall deaths were documented during 4 136 364 person years of follow-up since enrolment, including 8360 cardiovascular disease related deaths. In fully adjusted multivariable analyses, no significant association was observed between birth month, birth season, and overall mortality. Compared with women born in November, increased cardiovascular disease mortality was observed among those born from March to July (hazard ratio for March, 1.09, 95% confidence interval 0.98 to 1.21; April, 1.12, 1.00 to 1.24; May, 1.08, 0.98 to 1.20; June, 1.07, 0.96 to 1.19; and July 1.08, 0.98 to 1.20). Those born in April had the highest cardiovascular disease mortality, and those born in December had the lowest (December, 0.95, 0.85 to 1.06). The relative difference between the lowest and highest risk month was 17.89%. Women born in spring (1.10, 1.04 to 1.17) and summer (1.09, 1.03 to 1.16) had a higher cardiovascular disease mortality than women born in the autumn. Adjustment for familial and socioeconomic factors did not change these results. The relative difference between the lowest and highest risk season was 10.00%. CONCLUSION: Participants born in the spring and summer (especially those born in March-July) had a slight but significant increase in cardiovascular disease specific mortality. However, no seasonal birth month effect was observed among women for overall mortality. Familial and socioeconomic factors did not appear to alter these associations. Further studies are required to confirm these findings and reveal mechanisms of these seasonal birth month effects in cardiovascular disease mortality.


Asunto(s)
Enfermedades Cardiovasculares/mortalidad , Estaciones del Año , Factores de Tiempo , Adulto , Femenino , Humanos , Estudios Longitudinales , Persona de Mediana Edad , Modelos de Riesgos Proporcionales , Estudios Prospectivos , Factores de Riesgo , Factores Socioeconómicos
15.
Int Psychogeriatr ; 31(12): 1691-1693, 2019 12.
Artículo en Inglés | MEDLINE | ID: mdl-31856930
16.
J Contemp Dent Pract ; 20(10): 1179-1183, 2019 Oct 01.
Artículo en Inglés | MEDLINE | ID: mdl-31883253

RESUMEN

AIM: The purpose of this study was to find the correlation between dental caries and teeth loss in relation to gender, age, treatments with different therapies, time period being hospitalized, sugar consumption, smoking, and oral hygiene in mental disordered patients. OBJECTIVE: Evaluating therapeutic treatments in patients with mental illnesses, focusing on the effects on oral health. MATERIALS AND METHODS: This is a longitudinal cohort study conducted on patients who have been hospitalized from 5 years to 30 years. Patients were observed for 7 months (January 2019-July 2019) in the psychiatric hospital "Ali Mihali", in Vlora, Albania. In our study, 200 patients participated, of which 103 were females (51.5%) and 97 were males (48.5%). RESULTS: In the present study, we analyzed the oral health of patients within the age class of 30-70 years. We divided them into four age groups: 30-40, 41-50, 51-60, and 61-70 years. According to the ANOVA test, a strongest influence on caries manifestation and missing teeth was noticed during the time the patient was being hospitalized, with p values = 0.000 in both cases. The treatments done with different therapies also had a strong influence on the teeth loss with a p value = 0.001, while in carious teeth the p value was 0.004. This study showed that there is a strong statistically significant correlation between sugar consumption and smoking, in relation to caries manifestation and teeth loss, with p values = 0.000, respectively. CONCLUSION: These patients are a vulnerable group, if we consider their oral health. The present study proved that the most important reasons for their poor dental health are: bad oral hygiene, smoking, sugar consumption, adverse effects of medications, and the time period that these patients have been hospitalized. CLINICAL SIGNIFICANCE: By knowing the factors that have worsened the oral health of mental disordered patients, we can try to raise the awareness about caries reduction and to avoid teeth loss. How to cite this article: Canga M, Malagnino I, Malagnino G, et al. Evaluating Therapy Treatments in Patients with Mental Disorders in Relation to Oral Health. J Contemp Dent Pract 2019;20(10):1179-1183.


Asunto(s)
Caries Dental , Trastornos Mentales , Femenino , Humanos , Estudios Longitudinales , Masculino , Salud Bucal , Higiene Bucal
17.
J Opioid Manag ; 15(5): 389-405, 2019.
Artículo en Inglés | MEDLINE | ID: mdl-31849030

RESUMEN

OBJECTIVE: Characterize changes in intraoperative opioid and non-opioid administration over time and to evaluate self-reported pain scores in the immediate postoperative period. DESIGN: Single-center retrospective longitudinal study. SETTING: Academic medical center. PATIENTS, PARTICIPANTS: All patients presenting for surgery between 2011 and 2017 in both an inpatient and outpatient setting. MAIN OUTCOME MEASURE(S): Determine total intraoperative opioid administration using intravenous oral morphine equivalents standardized to weight and intraoperative non-opioid use. Furthermore, postoperative self-reported pain scores within 2 hours of completion of surgery are reported. RESULTS: A total of 112,167 individual cases were identified from March 2011 to June 2017. There was a sustained and significant reduction in intraoperative mean and median opioid administration [2011: 0.16 ± 0.15 mg/kg and 0.13 (0-4.92) mg/kg vs 2017: 0.09 ± 0.09 mg/kg and 0.07 (0-4.17) mg/kg]. These effects are seen in emergent vs elective surgery, ambulatory vs inpatient, preoperative opioid use vs no preoperative opioid use, and those with and without intraoperative loco-regional procedures. Although median number of intraoperative non-opioid analgesic agents was unchanged over time, average difference in the number of intraoperative non-opioids increased over time. Finally, pain scores decreased over time [2011: mean (standard deviation) and median (range): 5.1 ± 2.62 and 5.4 (0-10) vs 2017: 3.29 ± 3.27 and 3 (0-10)]. CONCLUSION: This study confirms that intraoperative opioid use has decreased over time with increased utilization of non-opioid analgesic adjuncts and a commensurate decrease in immediate postoperative pain.


Asunto(s)
Analgésicos Opioides , Analgésicos , Dolor Postoperatorio , Analgésicos/administración & dosificación , Analgésicos Opioides/administración & dosificación , Femenino , Humanos , Estudios Longitudinales , Masculino , Dimensión del Dolor , Dolor Postoperatorio/tratamiento farmacológico , Dolor Postoperatorio/prevención & control , Estudios Retrospectivos
18.
Medicine (Baltimore) ; 98(52): e18604, 2019 Dec.
Artículo en Inglés | MEDLINE | ID: mdl-31876762

RESUMEN

The various harmful impacts of distal radius fractures (DRFs) may cause adverse effects. Although previous studies have reported the adverse effects of DRFs on mortality, most studies were performed in adults of advanced age and paid little attention to confounding factors of mortality. Furthermore, most of these studies investigated the overall impact of DRFs on mortality without differentiating the specified causes of death.The purpose of the present study was to estimate the risk of mortality in DRF patients according to the cause of death.Data from the Korean National Health Insurance Service-National Sample Cohort (NHIS-NSC) from 2002 to 2013 were collected. A total of 27,295 DRF participants who were 50 years or older were 1:4 matched with control participants for age, sex, income, and region of residence. The causes of death were grouped into 12 classifications.DRFs were not associated with increased overall mortality. The adjusted hazard ratio (HR) of mortality was 1.04 (95% confidence interval [CI] = 0.98-1.11, P = .237). The adjusted HR for mortality was not significantly different according to age. The odds ratio of overall mortality was 1.03 (95% CI = 0.97-1.11, P = .329).DRFs were not associated with a significant increase in mortality.


Asunto(s)
Fracturas del Radio/mortalidad , Factores de Edad , Anciano , Estudios de Casos y Controles , Causas de Muerte , Femenino , Estudios de Seguimiento , Humanos , Estudios Longitudinales , Masculino , Persona de Mediana Edad , Oportunidad Relativa , Modelos de Riesgos Proporcionales , Factores de Riesgo , Factores Sexuales
19.
Sichuan Da Xue Xue Bao Yi Xue Ban ; 50(5): 725-730, 2019 Sep.
Artículo en Chino | MEDLINE | ID: mdl-31762245

RESUMEN

OBJECTIVE: To understand the relationship between obesity and depression in the elderly in China, and to explore whether there are differences between the genders. METHODS: The data were collected from the 2015 China Health and Retirement National Investigation (China Health and Retirement Longitudinal Study, CHARLS). The respondents were grouped according to depressive status. The difference of depressive status between the elderly male and female groups was examined by Chi-square test. The relationship between depression, obesity and the other sociological factors was analyzed by binary logistic regression. RESULTS: There were 4 019 valid cases, including 2 109 males (52.48%) and 1 910 females (47.52%). All the respondents were aged 60 years and over. There were 474 cases of central obesity (11.79%) and 2 418 cases of abdominal obesity (60.16%). There were significant differences in central obesity and abdominal obesity between the elderly male and female groups (P < 0.001). 1 304 cases suffered from depression, accounting for 32.45%, of which 539 cases were male (41.33%) and 765 cases were female (58.67%). Different groups of gender, central obesity and abdominal obesity had significant differences in depressive status (P < 0.001). The results of univariate analysis indicated that the characteristics of female, divorced/widowed/unmarried, in rural areas, having chronic diseases and functional loss were the risk factors for depression. The results of multivariate logistic regression analysis indicated that, in terms of the total sample, after adjustment for the confounding factors, both central obesity and abdominal obesity groups were less likely to suffer from depression. After stratified by gender, both central obesity and abdominal obesity were negatively correlated with depression. CONCLUSIONS: The elderly with central obesity or abdominal obesity are less likely to suffer from depression, regardless of gender.


Asunto(s)
Depresión/complicaciones , Obesidad Abdominal/complicaciones , Anciano , China/epidemiología , Femenino , Humanos , Modelos Logísticos , Estudios Longitudinales , Masculino , Persona de Mediana Edad
20.
Zhonghua Shao Shang Za Zhi ; 35(11): 804-810, 2019 Nov 20.
Artículo en Chino | MEDLINE | ID: mdl-31775469

RESUMEN

Objective: To explore the development trajectories of quality of life and acceptance of disability of burn patients in the rehabilitation treatment stage and the influencing factors. Methods: Totally 207 burn patients, including 157 males and 50 females, aged (40±13) years, who were in the rehabilitation treatment stage were selected by convenient sampling method from October 2016 to July 2017 in the Department of Burns of Fujian Medical University Union Hospital for this longitudinal study. At discharge and 1, 3, and 6 months after discharge, the patient's quality of life and acceptance of disability were scored using the Burn Specific Health Scale-Brief and Chinese Version of Acceptance of Disability Scale-Revised respectively. Taking the intercept, the slope, and the curve slope as latent variables, the latent second growth curve model was constructed for the quality of life and the acceptance of disability. The robust maximum likelihood estimation (MLR) method was used to estimate the mean, the variance, and the covariance, so as to analyze the discharge level, the growth rate, the acceleration, and the correlation among them. Taking the acceptance of disability, the gender, the cause of burn, the severity of burn, the existence of complications, the payment way, and the education level as covariates, the latent second growth curve model was constructed for the quality of life. The MLR method was used to estimate the influence of covariates on the discharge level, the growth rate, and the acceleration of the quality of life. Results: At discharge and 1, 3, and 6 months after discharge, the quality of life scores of patients were (102±36), (111±36), (118±37), and (122±37) points respectively, and the acceptance of disability scores were (73±17), (75±17), (77±17), and (78±18) points respectively. The estimated mean intercept of the quality of life and the acceptance of disability were 101.680 and 72.993 respectively at discharge, both of which showed a curve increasing trend in 1, 3, and 6 months after discharge (estimated mean slope=11.024, 3.086, t=15.376, 7.476, P<0.01), and the increasing rate (acceleration) gradually slowed down (estimated mean curve slope=-1.393, -0.426, t=-13.339, -4.776, P<0.01). There were significant individual differences in the discharge level and the acceleration of quality of life of patients (estimated intercept variance=1 174.527, t=9.332; estimated curve slope variance=2.379, t=6.402; P<0.01). There were significant individual differences in the discharge level, the growth rate, and the acceleration of patients' acceptance of disability (estimated intercept variance=267.017, t=9.262; estimated slope variance=32.264, t=2.356; estimated curve slope variance=0.882, t=2.939; P<0.05 or P<0.01). There was no significant correlation among the discharge level, the growth rate, and the acceleration of the quality of life and those of the acceptance of disability of patients (estimated intercept and slope=37.273, -1.457, t=0.859, -0.131; estimated intercept and curve slope=-6.712, -0.573, t=-1.089, -0.248; estimated slope and curve slope=-5.494, -5.988, t=-0.930, -2.512; P>0.05). Among the time-constant covariates, only the severity of burn and the presence of complications had a significant impact on the quality of life of patients at discharge (estimated intercept=-10.721, 5.522, t=-6.229, 1.977, P<0.05 or P<0.01). At discharge and 1, 3, and 6 months after discharge, the level of acceptance of disability had a positive impact on the quality of life of patients (standardized regression coefficient=0.616, 0.669, 0.681, 0.678, t=18.874, 21.660, 22.824, 22.123, P<0.01). Conclusions: The initial levels of quality of life and acceptance of disability of burn patients in the rehabilitation treatment stage are relatively low, both with a curve increasing trend over time, and the increasing rate gradually slows down. Patients with complications and serious burns have poor quality of life at discharge, while the acceptance of disability has a positive impact on the quality of life.


Asunto(s)
Quemaduras/psicología , Quemaduras/rehabilitación , Calidad de Vida , Adaptación Psicológica , Adulto , Quemaduras/fisiopatología , Personas con Discapacidad/psicología , Femenino , Humanos , Estudios Longitudinales , Masculino , Persona de Mediana Edad
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