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1.
BMC Infect Dis ; 20(1): 317, 2020 Apr 30.
Artículo en Inglés | MEDLINE | ID: mdl-32354369

RESUMEN

BACKGROUND: The novel coronavirus disease 2019 (COVID-19) outbreak started in Wuhan, Hubei, China since Dec 2019 and cases of infection have been continuously reported in various countries. It is now clear that the SARS-COV-2 coronavirus is transmissible from human to human. Nucleic acid detection is considered as the gold standard for the diagnosis of COVID-19. In this case report, we describe our experience in detection of SARS-COV-2 from a confirmed patient using nucleic acid test of bronchoalveolar-lavage fluid (BALF) samples but not nasopharyngeal swabs. CASE PRESENTATION: We present a case of severely ill SARS-COV-2 infected 46-year-old man with fever, coughing and chest tightness. We performed viral detection using his BALF samples and imaging method (CT) for confirmation. The patient received combination of interferonalfa-1b and ribavirin, lopinavir and ritonavir for antiviral treatment at different stages. Other medication was also given to him in combination for anti-inflammation, intestinal microbial regulation, phlegm elimination, liver protection and pulmonary fibrosis prevention purposes. We provided oxygen supply to him using BIPAP ventilator and high-flow humidification oxygen therapy instrument to facilitate respiration. The patient was cured and discharged. CONCLUSION: This case report described an effective supportive medication scheme to treat SARS-COV-2 infected patient and emphasized the necessity of detection of the viral genome using BALF samples and its significance in the diagnosis and prognosis of the disease.


Asunto(s)
Líquido del Lavado Bronquioalveolar/virología , Infecciones por Coronavirus/diagnóstico , Neumonía Viral/diagnóstico , ARN Viral/aislamiento & purificación , Antivirales/uso terapéutico , Betacoronavirus , China , Infecciones por Coronavirus/tratamiento farmacológico , Tos/etiología , Fiebre/etiología , Humanos , Pulmón/diagnóstico por imagen , Masculino , Persona de Mediana Edad , Nasofaringe/virología , Pandemias , Neumonía Viral/tratamiento farmacológico
3.
BMC Infect Dis ; 20(1): 329, 2020 May 07.
Artículo en Inglés | MEDLINE | ID: mdl-32381073

RESUMEN

BACKGROUND: Although people of all ages are susceptible to the novel coronavirus infection, which is presently named "Coronavirus Disease 2019" (COVID-19), there has been relatively few cases reported among children. Therefore, it is necessary to understand the clinical characteristics of COVID-19 in children and the differences from adults. CASE PRESENTATION: We report one pediatric case of COVID-19. A 14-month-old boy was admitted to the hospital with a symptom of fever, and was diagnosed with a mild form of COVID-19. The child's mother and grandmother also tested positive for SARS-CoV-2 RNA. However, the lymphocyte counts were normal. The chest computed tomography (CT) revealed scattered ground glass opacities in the right lower lobe close to the pleura and resorption after the treatment. The patient continued to test positive for SARS-CoV-2 RNA in the nasopharyngeal swabs and stool at 17 days after the disappearance of symptoms. CONCLUSION: The present pediatric case of COVID-19 was acquired through household transmission, and the symptoms were mild. Lymphocyte counts did not significantly decrease. The RNA of SARS-CoV-2 in stool and nasopharyngeal swabs remained positive for an extended period of time after the disappearance of symptoms. This suggests that attention should be given to the potential contagiousness of pediatric COVID-19 cases after clinical recovery.


Asunto(s)
Infecciones por Coronavirus/diagnóstico , Coronavirus , Heces/virología , Fiebre/etiología , Pulmón/diagnóstico por imagen , Nasofaringe/virología , Neumonía Viral/diagnóstico por imagen , Adulto , Betacoronavirus , Técnicas de Laboratorio Clínico , Coronavirus/genética , Coronavirus/aislamiento & purificación , Infecciones por Coronavirus/diagnóstico por imagen , Infecciones por Coronavirus/epidemiología , Composición Familiar , Humanos , Lactante , Recuento de Linfocitos , Masculino , Pandemias , Neumonía Viral/epidemiología , Reacción en Cadena de la Polimerasa , Síndrome Respiratorio Agudo Grave/transmisión , Tomografía Computarizada por Rayos X
4.
Can J Surg ; 63(3): E231-E232, 2020 May 08.
Artículo en Inglés | MEDLINE | ID: mdl-32386473

RESUMEN

Summary: Postoperative fever is common following orthopedic trauma surgery. As the prevalence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection increases in the community, migration into the acute care hospital setting intensifies, creating confusion when fever develops postoperatively. The transmission dynamics of SARS-CoV-2 make it difficult to adequately gauge and pinpoint risk groups with questionnaires at the time of hospital admission. This is particularly problematic when asymptomatic or presymptomatic patients infected with SARS-CoV-2 require urgent surgery and cannot be screened effectively. One approach is to treat every patient as though they were SARS-CoV-2-positive in preparation for surgery, but doing so could exacerbate shortages of personal protective equipment and staffing limitations. Uncertainty regarding the etiology of postoperative fever could be significantly reduced by universal SARS-CoV-2 testing of all surgical patients at the time of hospital admission in addition to routine screening, but testing capacity and a rapid turnaround time would be required.


Asunto(s)
Infecciones por Coronavirus/diagnóstico , Transmisión de Enfermedad Infecciosa/prevención & control , Fiebre/etiología , Tamizaje Masivo/métodos , Procedimientos Ortopédicos , Neumonía Viral/diagnóstico , Heridas y Traumatismos/cirugía , Betacoronavirus/aislamiento & purificación , Infecciones por Coronavirus/complicaciones , Infecciones por Coronavirus/transmisión , Fiebre/virología , Humanos , Tamizaje Masivo/normas , Procedimientos Ortopédicos/efectos adversos , Pandemias , Equipo de Protección Personal/provisión & distribución , Neumonía Viral/complicaciones , Neumonía Viral/transmisión , Precauciones Universales/métodos , Heridas y Traumatismos/complicaciones
5.
Tidsskr Nor Laegeforen ; 140(7)2020 05 05.
Artículo en Inglés, Noruego | MEDLINE | ID: mdl-32378844

RESUMEN

BACKGROUND: The COVID-19 outbreak is presenting the health system with new challenges, and there is a great need for knowledge about symptoms, clinical findings and course of illness in patients admitted to Norwegian hospitals with COVID-19. MATERIAL AND METHOD: In this observational qualitative study, all patients admitted to a Norwegian local hospital (Bærum Hospital) with proven COVID-19 infection were included consecutively from the start of the outbreak. We present here patient characteristics, symptoms, clinical findings, experience of using clinical scoring systems and course of illness based on data in medical records. RESULTS: In the period 9-31 March 2020, 42 patients, of whom 28 (67 %) were men, were admitted to hospital with COVID-19 infection. The median age was 72.5 years (range 30-95). Fever (79 %), reduced general condition (79 %), dyspnoea (69 %) and cough (67 %) were the most common symptoms. A total of nine patients (21 %) had a critical course of illness with treatment in the Intensive Care Department and/or death during their stay in hospital. Patients with a critical course had a higher average score on National Early Warning Score 2 (NEWS2) on admission (7.6 vs 3.3). Only one of the most severely ill patients scored ≥ 2 on the quick Sepsis-related Organ Failure Assessment (qSOFA) on admission. INTERPRETATION: Most patients admitted to our hospital with COVID-19 had a fever and respiratory tract symptoms. A high percentage of patients had a critical course of illness. A NEWS2 score of ≥ 5 on admission may be a useful aid in identifying patients at risk of a critical course of illness, while CRB-65 and qSOFA score ≥ 2 proved to be of little usefulness for this purpose in our material.


Asunto(s)
Infecciones por Coronavirus , Enfermedad Crítica , Pandemias , Neumonía Viral , Índice de Severidad de la Enfermedad , Adulto , Anciano , Anciano de 80 o más Años , Betacoronavirus , Técnicas de Laboratorio Clínico , Infecciones por Coronavirus/complicaciones , Infecciones por Coronavirus/diagnóstico , Infecciones por Coronavirus/epidemiología , Tos/etiología , Disnea/etiología , Servicio de Urgencia en Hospital , Fiebre/etiología , Humanos , Masculino , Persona de Mediana Edad , Noruega/epidemiología , Puntuaciones en la Disfunción de Órganos , Neumonía Viral/complicaciones , Neumonía Viral/diagnóstico , Neumonía Viral/epidemiología , Estudios Retrospectivos
6.
Euro Surveill ; 25(18)2020 05.
Artículo en Inglés | MEDLINE | ID: mdl-32400362

RESUMEN

Data on features of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in children and adolescents are scarce. We report preliminary results of an Italian multicentre study comprising 168 laboratory-confirmed paediatric cases (median: 2.3 years, range: 1 day-17.7 years, 55.9% males), of which 67.9% were hospitalised and 19.6% had comorbidities. Fever was the most common symptom, gastrointestinal manifestations were frequent; two children required intensive care, five had seizures, 49 received experimental treatments and all recovered.


Asunto(s)
Enfermedad Crónica/epidemiología , Coinfección/epidemiología , Infecciones por Coronavirus/diagnóstico , Coronavirus/aislamiento & purificación , Pandemias/prevención & control , Neumonía Viral/diagnóstico , Adolescente , Antivirales/uso terapéutico , Betacoronavirus , Niño , Preescolar , Técnicas de Laboratorio Clínico , Coinfección/virología , Comorbilidad , Infecciones por Coronavirus/epidemiología , Infecciones por Coronavirus/terapia , Diarrea/etiología , Brotes de Enfermedades , Heces/virología , Femenino , Fiebre/etiología , Hospitales Pediátricos , Humanos , Huésped Inmunocomprometido , Lactante , Recién Nacido , Italia/epidemiología , Masculino , Ventilación no Invasiva/métodos , Neumonía Viral/epidemiología , Neumonía Viral/terapia , Inhibidores de Proteasas/uso terapéutico , Estudios Retrospectivos , Síndrome Respiratorio Agudo Grave/diagnóstico , Síndrome Respiratorio Agudo Grave/epidemiología , Síndrome Respiratorio Agudo Grave/terapia , Resultado del Tratamiento
7.
Ned Tijdschr Geneeskd ; 1642020 05 14.
Artículo en Holandés | MEDLINE | ID: mdl-32406638

RESUMEN

OBJECTIVE: Evaluation of a diagnostic algorithm for estimating the risk of COVID-19 in patients who are referred to an emergency department for being suspected of having the disease. DESIGN: Retrospective study. METHOD: Patients with fever with no apparent cause and patients with recently developed respiratory symptoms, whether or not in combination with fever, were routinely given a PCR test, blood tests (lymphocyte count and LDH levels) and a chest CT scan. The CT scan was assessed according to the CO-RADS classification. Based on the findings, the patients were divided into 3 cohorts (proven COVID-19, strong suspicion of COVID-19, and low suspicion of COVID-19) and the appropriate isolation measures were taken. RESULTS: In the period from 8 to 31 March 2020, the algorithm was applied to 312 patients. COVID-19 was proven for 69 (22%) patients. COVID-19 was strongly suspected for 151 (48%) patients and suspicion was low for the remaining 92 (29%) patients. The percentage of patients with positive PCR results and the percentage of patients with abnormal laboratory test results increased as the CO-RADS score increased. Among patients with a CO-RADS score of 4 or 5, this percentage increased further when they also had lymphopenia or elevated LDH levels. We have adjusted the flowchart based on our findings. CONCLUSION: In case of patients who have been referred to an emergency department for suspected COVID-19, a good COVID-19 risk assessment can be made on the basis of clinical signs, laboratory abnormalities and low-dose CT scans. Even before the results of the PCR test are known and even if the results are negative, patients can be classified as 'proven COVID-19 patients' using the algorithm.


Asunto(s)
Algoritmos , Betacoronavirus , Infecciones por Coronavirus/diagnóstico , Servicio de Urgencia en Hospital , Neumonía Viral/diagnóstico , Triaje , Adolescente , Adulto , Anciano , Anciano de 80 o más Años , Betacoronavirus/aislamiento & purificación , Femenino , Fiebre/etiología , Humanos , Masculino , Persona de Mediana Edad , Pandemias , Estudios Retrospectivos , Medición de Riesgo , Tomografía Computarizada por Rayos X , Adulto Joven
8.
Telemed J E Health ; 26(4): 487-494, 2020 04.
Artículo en Inglés | MEDLINE | ID: mdl-32233973

RESUMEN

Satisfactory outcome was observed in one mild case and one severe case of COVID-19 pneumonia after the use of the online/offline multidisciplinary quarantine observation form, online monitoring, and classified diagnosis and treatment, as well as strict compliance with quarantine measures. Conditions of both patients were improved, and cross-infection and disease onset clustering were not observed. The multidisciplinary self-quarantine model provides early judgment, identification, and treatment of disease, improves compliance with early rehabilitation, increases confidence in recovery, and enhances self-management capabilities. This model is applicable to the current novel coronavirus pneumonia epidemic and can actively promote the management of suspected or confirmed mild cases, monitoring of critical cases, and self-management of discharged patients. The application of this new management model is worthy of being promoted in our specialized treatment facilities and in countries with severe epidemics.


Asunto(s)
Infecciones por Coronavirus/diagnóstico por imagen , Internet , Neumonía Viral/diagnóstico por imagen , Cuarentena/métodos , Automanejo , Telemedicina , Adulto , Betacoronavirus , Infecciones por Coronavirus/complicaciones , Infecciones por Coronavirus/rehabilitación , Tos/etiología , Epidemias , Fiebre/etiología , Humanos , Control de Infecciones/métodos , Transmisión de Enfermedad Infecciosa de Paciente a Profesional , Masculino , Monitoreo Fisiológico , Pandemias , Grupo de Atención al Paciente , Médicos , Neumonía Viral/complicaciones , Neumonía Viral/rehabilitación , Terapia Respiratoria , Conducta de Reducción del Riesgo , Índice de Severidad de la Enfermedad , Telemedicina/métodos , Tomografía Computarizada por Rayos X
9.
J Nepal Health Res Counc ; 18(1): 135-137, 2020 Apr 20.
Artículo en Inglés | MEDLINE | ID: mdl-32335609

RESUMEN

The novel coronavirus (COVID-19) cause various symptoms such as pneumonia, fever, breathing difficult and lung infection. Till now, total 9 cases are reported in Nepal and 4 cases from this province. This case series is to describe the initial clinical features of COVID-19 among the patients admitted in isolation ward of Seti Provincial Hospital. Oropharyngeal swab was taken from all four patients and sample was transfer to national reference laboratory. Three patients were coming from infected country and one is local transmission. Age of patients was range from 20 to 40 years of age with male preponderance. The patient coming from United Arab Emirate was presented with mild symptoms and others were asymptomatic. More tests, contact tracing and keeping them in quarantine are the necessitated action need to be taken by government of Nepal. Keywords: COVID-19; local transmission; oropharyngeal swab.


Asunto(s)
Infecciones por Coronavirus/epidemiología , Coronavirus , Brotes de Enfermedades/prevención & control , Neumonía Viral/epidemiología , Cuarentena , Viaje , Adulto , Betacoronavirus , Infecciones por Coronavirus/transmisión , Tos/etiología , Fiebre/etiología , Humanos , India , Nepal/epidemiología , Pandemias , Neumonía Viral/transmisión , Emiratos Árabes Unidos , Adulto Joven
11.
Tidsskr Nor Laegeforen ; 140(6)2020 04 21.
Artículo en Inglés, Noruego | MEDLINE | ID: mdl-32321232

RESUMEN

BACKGROUND: COVID-19 can cause a fatal outcome in elderly patients, as this case report illustrates. CASE PRESENTATION: An active male in his nineties with a high level of function, despite several severe chronic diseases, was admitted to Oslo University Hospital after two days of fatigue, fever, dyspnoea and dry cough. He scored qSOFA 1 of 3 points due to high respiratory rate, and SIRS 2 of 4 points due to high respiratory rate and fever of 39.4º C. PCR for influenza virus was negative and he received benzylpenicillin for pneumonia. The chest X-ray taken initially showed no lung affection. On day 5 after symptom debut he was tested for COVID-19 which was positive. He had not been travelling to high-risk areas or been exposed to any known confirmed COVID-19 patients. On the same day, a chest CT scan was performed that showed ground-glass opacities. In subsequent days the patient's health rapidly deteriorated. He developed irreversible respiratory failure with hypoxia without hypercapnia despite substantial oxygen support. Chest X-ray taken on disease day 7 showed progression of consolidations. The patient died 9 days after symptom debut. INTERPRETATION: This case illustrates a severe course of COVID-19 with fatal outcome. The patient was also one of the earliest admitted with COVID-19 in a Norwegian hospital and marked a new phase of the epidemic, as he had not been travelling to high-risk areas or been exposed to any confirmed COVID-19 patients.


Asunto(s)
Betacoronavirus , Infecciones por Coronavirus , Pandemias , Neumonía Viral , Insuficiencia Respiratoria , Anciano de 80 o más Años , Infecciones por Coronavirus/complicaciones , Infecciones por Coronavirus/diagnóstico por imagen , Tos/etiología , Notificación de Enfermedades , Resultado Fatal , Fiebre/etiología , Humanos , Masculino , Neumonía Viral/complicaciones , Neumonía Viral/diagnóstico por imagen , Radiografía Torácica , Insuficiencia Respiratoria/etiología , Tomografía Computarizada por Rayos X
12.
Zhongguo Dang Dai Er Ke Za Zhi ; 22(4): 290-293, 2020 Apr.
Artículo en Chino | MEDLINE | ID: mdl-32312363

RESUMEN

OBJECTIVE: To study the clinical features of children with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. METHODS: A retrospective analysis was performed for the clinical data of 115 children who were diagnosed with SARS-CoV-2 infection in the Wuhan Children's Hospital, including general information, history of close contact with individuals of SARS-CoV-2 infection, early clinical symptoms, laboratory examination results, and lung CT results. RESULTS: Among the 115 children, there were 73 boys (63.5%) and 42 girls (36.5%), with a male/female ratio of 1:0.58. Of the 115 children, 105 (91.3%) had a definite history of close contact with individuals of SARS-CoV-2-infection. An increase in alanine aminotransferase was observed in 11 children (9.6%) and an increase in CK-MB was found in 34 children (29.6%). As for clinical symptoms, 29 children (25.2%) had fever, 47 (40.9%) had respiratory symptoms (including cough, rhinorrhea, and nasal congestion), and 61 (53.0%) were asymptomatic. Lung CT findings showed ground glass opacity, fiber opacities, patchy changes, and pulmonary consolidation in 49 children (42.6%), among whom 2 children had "white lung"; 39 children (33.9%) only had lung texture enhancement and 27 children (23.5%) had no pulmonary imaging changes. Among the 115 children, 3 were critically ill, among whom 1 had been cured and the other 2 were under continuous treatment. CONCLUSIONS: Most of the children with SARS-CoV-2 infection have a close contact history. Critical cases are rare and there is a high proportion of asymptomatic infection.


Asunto(s)
Infecciones por Coronavirus , Pandemias , Neumonía Viral , Alanina Transaminasa/sangre , Enfermedades Asintomáticas , Betacoronavirus , Niño , Técnicas de Laboratorio Clínico , Trazado de Contacto , Infecciones por Coronavirus/complicaciones , Infecciones por Coronavirus/diagnóstico , Infecciones por Coronavirus/diagnóstico por imagen , Tos/etiología , Enfermedad Crítica , Femenino , Fiebre/etiología , Humanos , Masculino , Neumonía Viral/complicaciones , Neumonía Viral/diagnóstico por imagen , Estudios Retrospectivos , Tomografía Computarizada por Rayos X , Resultado del Tratamiento
13.
Zhongguo Dang Dai Er Ke Za Zhi ; 22(4): 294-298, 2020 Apr.
Artículo en Chino | MEDLINE | ID: mdl-32312364

RESUMEN

OBJECTIVE: To study the clinical features of children with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. METHODS: A retrospective analysis was performed for the clinical data of 13 children with SARS-CoV-2 infection who hospitalized in a Changsha hospital. RESULTS: All 13 children had the disease onset due to family aggregation. Of the 13 children, 2 had no symptoms, and the other 11 children had the clinical manifestations of fever, cough, pharyngeal discomfort, abdominal pain, diarrhea, convulsions, or vomiting. As for clinical typing, 7 had mild type, 5 had common type, and 1 had severe type. The median duration of fever was 2 days in 6 children. All 13 children had normal levels of peripheral blood lymphocyte counts, immunoglobulins, CD4, CD8, and interleukin-6. The median time to clearance of SARS-CoV-2 was 13 days in the nasopharyngeal swabs of the 13 children. Three children presented false negatives for RT-PCR of SARS-CoV-2. SARS-CoV-2 RNA remained detectable in stools for 12 days after the nasopharyngeal swab test yielded a negative result. Abnormal CT findings were observed in 6 children. All 13 children were cured and discharged and they were normal at 2 weeks after discharge. CONCLUSIONS: Intra-family contact is the main transmission route of SARS-CoV-2 infection in children, and there is also a possibility of fecal-oral transmission. Mild and common types are the major clinical types in children with SARS-CoV-2 infection, and cytokine storm is not observed. Children with SARS-CoV-2 infection tend to have a good short-term prognosis, and follow-up is needed to observe their long-term prognosis. Multiple nucleic acid tests should be performed for patients with SARS-CoV-2 infection and their close contacts by multiple site sampling.


Asunto(s)
Betacoronavirus , Infecciones por Coronavirus , Pandemias , Neumonía Viral , Dolor Abdominal/etiología , Enfermedades Asintomáticas , Betacoronavirus/patogenicidad , Biomarcadores/análisis , Niño , China , Técnicas de Laboratorio Clínico , Infecciones por Coronavirus/complicaciones , Infecciones por Coronavirus/diagnóstico , Infecciones por Coronavirus/inmunología , Infecciones por Coronavirus/transmisión , Tos/etiología , Diarrea/etiología , Heces/virología , Fiebre/etiología , Humanos , Recuento de Linfocitos , Neumonía Viral/complicaciones , Neumonía Viral/diagnóstico , Neumonía Viral/inmunología , Neumonía Viral/transmisión , ARN Viral/análisis , Estudios Retrospectivos , Convulsiones/etiología , Tomografía Computarizada por Rayos X
14.
Artículo en Inglés | MEDLINE | ID: mdl-32224986

RESUMEN

The breakthrough of novel coronavirus (2019-nCoV) in Wuhan, a city of China, has damaged the status of health and quality of life. In the sequel of this epidemic or contagious disease, the patient experiences fever, chest paint, chills, a rapid heartbeat, breathing difficulties, pneumonia, and kidney failure. It has been suggested that this disease can spread through human-to-human transmission or by super spreading. By the help of the non-invasive fluid "saliva", it is easy to detect the virus. This can help with the comfort of the patient as well as healthcare personnel. Under this perspective, we discuss the epidemic situation of 2019-nCOV and its relationship with human saliva.


Asunto(s)
Infecciones por Coronavirus/diagnóstico , Coronavirus , Neumonía Viral/diagnóstico , Pruebas en el Punto de Atención , Saliva/virología , Betacoronavirus , Técnicas de Laboratorio Clínico , Infecciones por Coronavirus/epidemiología , Infecciones por Coronavirus/transmisión , Infecciones por Coronavirus/virología , Brotes de Enfermedades , Transmisión de Enfermedad Infecciosa , Fiebre/etiología , Humanos , Pandemias , Neumonía Viral/virología , Saliva/química
15.
Artículo en Inglés | MEDLINE | ID: mdl-32244425

RESUMEN

Predicting the number of new suspected or confirmed cases of novel coronavirus disease 2019 (COVID-19) is crucial in the prevention and control of the COVID-19 outbreak. Social media search indexes (SMSI) for dry cough, fever, chest distress, coronavirus, and pneumonia were collected from 31 December 2019 to 9 February 2020. The new suspected cases of COVID-19 data were collected from 20 January 2020 to 9 February 2020. We used the lagged series of SMSI to predict new suspected COVID-19 case numbers during this period. To avoid overfitting, five methods, namely subset selection, forward selection, lasso regression, ridge regression, and elastic net, were used to estimate coefficients. We selected the optimal method to predict new suspected COVID-19 case numbers from 20 January 2020 to 9 February 2020. We further validated the optimal method for new confirmed cases of COVID-19 from 31 December 2019 to 17 February 2020. The new suspected COVID-19 case numbers correlated significantly with the lagged series of SMSI. SMSI could be detected 6-9 days earlier than new suspected cases of COVID-19. The optimal method was the subset selection method, which had the lowest estimation error and a moderate number of predictors. The subset selection method also significantly correlated with the new confirmed COVID-19 cases after validation. SMSI findings on lag day 10 were significantly correlated with new confirmed COVID-19 cases. SMSI could be a significant predictor of the number of COVID-19 infections. SMSI could be an effective early predictor, which would enable governments' health departments to locate potential and high-risk outbreak areas.


Asunto(s)
Infecciones por Coronavirus , Minería de Datos , Pandemias , Neumonía Viral , Medios de Comunicación Sociales , Betacoronavirus , Simulación por Computador , Coronavirus , Infecciones por Coronavirus/complicaciones , Infecciones por Coronavirus/epidemiología , Infecciones por Coronavirus/prevención & control , Tos/epidemiología , Tos/etiología , Brotes de Enfermedades/prevención & control , Disnea/epidemiología , Disnea/etiología , Fiebre/epidemiología , Fiebre/etiología , Predicción , Humanos , Pandemias/prevención & control , Neumonía/epidemiología , Neumonía/etiología , Neumonía Viral/complicaciones , Neumonía Viral/epidemiología , Neumonía Viral/prevención & control , Medición de Riesgo , Motor de Búsqueda , Medios de Comunicación Sociales/estadística & datos numéricos
16.
BMC Infect Dis ; 20(1): 311, 2020 Apr 29.
Artículo en Inglés | MEDLINE | ID: mdl-32345226

RESUMEN

BACKGROUND: Since December 2019, the 2019 coronavirus disease (COVID-19) has expanded to cause a worldwide outbreak that more than 600,000 people infected and tens of thousands died. To date, the clinical characteristics of COVID-19 patients in the non-Wuhan areas of Hubei Province in China have not been described. METHODS: We retrospectively analyzed the clinical characteristics and treatment progress of 91 patients diagnosed with COVID-19 in Jingzhou Central Hospital. RESULTS: Of the 91 patients diagnosed with COVID-19, 30 cases (33.0%) were severe and two patients (2.2%) died. The severe disease group tended to be older (50.5 vs. 42.0 years; p = 0.049) and have more chronic disease (40% vs. 14.8%; p = 0.009) relative to mild disease group. Only 73.6% of the patients were quantitative polymerase chain reaction (qPCR)-positive on their first tests, while typical chest computed tomography images were obtained for each patient. The most common complaints were cough (n = 75; 82.4%), fever (n = 59; 64.8%), fatigue (n = 35; 38.5%), and diarrhea (n = 14; 15.4%). Non-respiratory injury was identified by elevated levels of aspartate aminotransferase (n = 18; 19.8%), creatinine (n = 5; 5.5%), and creatine kinase (n = 14; 15.4%) in laboratory tests. Twenty-eight cases (30.8%) suffered non-respiratory injury, including 50% of the critically ill patients and 21.3% of the mild patients. CONCLUSIONS: Overall, the mortality rate of patients in Jingzhou was lower than that of Wuhan. Importantly, we found liver, kidney, digestive tract, and heart injuries in COVID-19 cases besides respiratory problems. Combining chest computed tomography images with the qPCR analysis of throat swab samples can improve the accuracy of COVID-19 diagnosis.


Asunto(s)
Betacoronavirus , Infecciones por Coronavirus/complicaciones , Neumonía Viral/complicaciones , Adulto , China/epidemiología , Infecciones por Coronavirus/diagnóstico por imagen , Infecciones por Coronavirus/epidemiología , Infecciones por Coronavirus/terapia , Tos/etiología , Diarrea/etiología , Brotes de Enfermedades , Fatiga/etiología , Femenino , Fiebre/etiología , Humanos , Masculino , Persona de Mediana Edad , Pandemias , Neumonía Viral/diagnóstico por imagen , Neumonía Viral/epidemiología , Neumonía Viral/terapia , Estudios Retrospectivos , Tomografía Computarizada por Rayos X
19.
Crit Rev Oncol Hematol ; 149: 102922, 2020 May.
Artículo en Inglés | MEDLINE | ID: mdl-32244162

RESUMEN

We compared the Multinational Association of Supportive Care in Cancer (MASCC) and Clinical Index of Stable Febrile Neutropenia (CISNE) scores for identifying serious complications in febrile neutropenia patients. We searched MEDLINE, PubMed, EMBASE, and Cochrane Database of Systematic Reviews from inception to March 19, 2019. Two reviewers independently screened citations, extracted data, and assessed quality. We included 26 studies, totalling 6617 patients. Pooled sensitivity and specificity for MASCC < 21 was 55.6 % (95 % CI: 46.2 %-64.5%) and 86.0 % (95 % CI: 81.3 %-89.7 %), respectively. Pooled sensitivity and specificity for CISNE ≥ 3 was 78.9 % (95 % CI: 65.3 %-88.1 %) and 64.9 % (95 % CI: 49.6 %-77.7 %), respectively. Pooled sensitivity and specificity for CISNE ≥ 1 was 96.7 % (95 % CI: 93.6 %-98.3 %) and 22.2 % (95 % CI: 15.6 %-30.4 %), respectively. The CISNE score had higher sensitivity and may be more useful than the MASCC score in the acute setting.


Asunto(s)
Antineoplásicos/efectos adversos , Neutropenia Febril/inducido químicamente , Fiebre/complicaciones , Neoplasias/tratamiento farmacológico , Adulto , Antineoplásicos/uso terapéutico , Neutropenia Febril/diagnóstico , Fiebre/etiología , Humanos , Neoplasias/complicaciones , Valor Predictivo de las Pruebas , Pronóstico , Medición de Riesgo , Sensibilidad y Especificidad , Índice de Severidad de la Enfermedad , Resultado del Tratamiento
20.
Arch Iran Med ; 23(4): 268-271, 2020 04 01.
Artículo en Inglés | MEDLINE | ID: mdl-32271601

RESUMEN

Since December 2019, there has been an outbreak of a novel coronavirus (COVID-19) infection in Wuhan, China. Meanwhile, the outbreak also drew attention and concern from the World Health Organization (WHO). COVID-19 is another human infectious disease caused by coronavirus. The transmission of COVID-19 is potent and the infection rate is fast. Since there is no specific drug for COVID-19, the treatment is mainly symptomatic supportive therapy. In addition, it should be pointed out that patients with severe illness need more aggressive treatment and meticulous care. Recently, accurate RNA detection has been decisive for the diagnosis of COVID-19. The development of highly sensitive RT-PCR has facilitated epidemiological studies that provide insight into the prevalence, seasonality, clinical manifestations and course of COVID-19 infection. In this review, we summarize the epidemiology and characteristics of COVID-19.


Asunto(s)
Betacoronavirus , Infecciones por Coronavirus , Susceptibilidad a Enfermedades , Pandemias , Neumonía Viral , Adolescente , Adulto , Anciano , Betacoronavirus/patogenicidad , Niño , Preescolar , China/epidemiología , Técnicas de Laboratorio Clínico , Infecciones por Coronavirus/complicaciones , Infecciones por Coronavirus/diagnóstico , Infecciones por Coronavirus/epidemiología , Tos/etiología , Brotes de Enfermedades , Femenino , Fiebre/etiología , Humanos , Lactante , Persona de Mediana Edad , Neumonía Viral/complicaciones , Neumonía Viral/diagnóstico , Neumonía Viral/epidemiología , Neumonía Viral/etiología , Embarazo , Estudios Seroepidemiológicos , Adulto Joven
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