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1.
Sensors (Basel) ; 21(5)2021 Mar 07.
Artículo en Inglés | MEDLINE | ID: mdl-33799930

RESUMEN

BACKGROUND: In the dental field, digital technology has created new opportunities for orthodontists to integrate their clinical practice, and for patients to collect information about orthodontics and their treatment, which is called "teledentistry." Dental monitoring (DM) is a recently introduced orthodontic application that combines safe teledentistry with artificial intelligence (AI) using a knowledge-based algorithm, allowing an accurate semi-automatic monitoring of the treatment. Dental Monitoring is the world's first SaaS (Software as a Service) application designed for remote monitoring of dental treatment, developed in Paris, France, with Philippe Salah as the Co-founder and CEO. CASES PRESENTATION: This report describes two cases in which DM system was essential to achieve the control of certain movements: it was possible to follow the movement, even if complex, such as the anterior cross of an adult patient and a lack of space in the canine of the growing patient. The software analyzed the fit and retention of the aligner, thus ensuring correct biomechanics. They were treated during the COVID-19 pandemic lockdown with aligners. The first case is a growing patient who was monitored during an interceptive orthodontic treatment to manage a retained upper canine. The second case is an adult patient forced to finalize his treatment of upper lateral incisor crossbite. The software analyzed the fit and retention of the aligner, thus ensuring correct biomechanics. CONCLUSIONS: DM system appears to be a promising method, useful for improving the interaction between doctor and patient, generally acceptable and useful to patients, even in critical clinical situations, at least in cases with optimal compliance and ability to use the tool properly.


Asunto(s)
Inteligencia Artificial , Diseño de Aparato Ortodóncico , Programas Informáticos , Telemedicina , Técnicas de Movimiento Dental , Adulto , Control de Enfermedades Transmisibles , Francia , Humanos , Pandemias
2.
Wiad Lek ; 74(2): 341-350, 2021.
Artículo en Inglés | MEDLINE | ID: mdl-33813498

RESUMEN

OBJECTIVE: The aim: The purpose of this article is to expose the essence of the concept of the human right to life, including in the content of this right, the duty of the state to maintain and develop general conditions for a dignified human life. PATIENTS AND METHODS: Materials and methods: The article explores the modern concept of understanding the human right to life. The article analyzes the constitutions, other regulations, as well as the experience of different countries in the world on this issue (in particular, the countries of Western and Eastern Europe, Latin America, USA). The empirical basis of this research consists of two judgments of the Constitutional Court of Ukraine, Resolution of the Plenum of the Supreme Court of Ukraine «On Judicial Practice in Cases of Crimes against the Life and Health of a Person¼ of February 7, 2003, № 2, and judgments of the European Court of Human Rights (Case of Lambert and others v. France of 5 June 2015, Case Hristozov and others v. Bulgaria of 13 November 2012, Case G. N. and others v. Italy of 01 December 2009) on issues related to the human right to life. The application of methods and techniques of scientific knowledge is conditioned by a systematic approach, which enables them to consider outlined problems in the unity of their social content and legal form. In particular, the formal-logical method, methods of analysis and synthesis, comparative-legal method, formal legal and statistical methods are used. CONCLUSION: Conclusions: The modern approach to understanding the human right to life presupposes that it is the state's responsibility to protect that right, to take appropriate measures to remedy the general conditions in society that may endanger life or prevent individuals from living a dignified life.


Asunto(s)
Valor de la Vida , Europa Oriental , Francia , Humanos , Italia , Ucrania
3.
Euro Surveill ; 26(13)2021 04.
Artículo en Inglés | MEDLINE | ID: mdl-33797392

RESUMEN

Two cases of confirmed SARS-CoV-2 infection with the B.1.351 variant were reported in France in mid-January, 2020. These cases attended a gathering in Mozambique in mid-December 2020. Investigations led to the identification of five imported cases responsible for 14 transmission chains and a total 36 cases. Epidemiological characteristics seemed comparable to those described before the emergence of the South African variant B.1.351. The lack of tertiary transmission outside of the personal sphere suggests that distancing and barrier measures were effective.


Asunto(s)
/diagnóstico , /genética , Viaje , Adolescente , Adulto , Grupo de Ascendencia Continental Africana , Anciano , /transmisión , Niño , Enfermedades Transmisibles Importadas , Femenino , Francia/epidemiología , Humanos , Masculino , Persona de Mediana Edad , Mozambique/etnología , Adulto Joven
4.
Euro Surveill ; 26(13)2021 04.
Artículo en Inglés | MEDLINE | ID: mdl-33797390

RESUMEN

BackgroundChildren have a low rate of COVID-19 and secondary severe multisystem inflammatory syndrome (MIS) but present a high prevalence of symptomatic seasonal coronavirus infections.AimWe tested if prior infections by seasonal coronaviruses (HCoV) NL63, HKU1, 229E or OC43 as assessed by serology, provide cross-protective immunity against SARS-CoV-2 infection.MethodsWe set a cross-sectional observational multicentric study in pauci- or asymptomatic children hospitalised in Paris during the first wave for reasons other than COVID (hospitalised children (HOS), n = 739) plus children presenting with MIS (n = 36). SARS-CoV-2 antibodies directed against the nucleoprotein (N) and S1 and S2 domains of the spike (S) proteins were monitored by an in-house luciferase immunoprecipitation system assay. We randomly selected 69 SARS-CoV-2-seropositive patients (including 15 with MIS) and 115 matched SARS-CoV-2-seronegative patients (controls (CTL)). We measured antibodies against SARS-CoV-2 and HCoV as evidence for prior corresponding infections and assessed if SARS-CoV-2 prevalence of infection and levels of antibody responses were shaped by prior seasonal coronavirus infections.ResultsPrevalence of HCoV infections were similar in HOS, MIS and CTL groups. Antibody levels against HCoV were not significantly different in the three groups and were not related to the level of SARS-CoV-2 antibodies in the HOS and MIS groups. SARS-CoV-2 antibody profiles were different between HOS and MIS children.ConclusionPrior infection by seasonal coronaviruses, as assessed by serology, does not interfere with SARS-CoV-2 infection and related MIS in children.


Asunto(s)
Anticuerpos Antivirales/inmunología , Coronavirus Humano OC43 , Síndrome de Respuesta Inflamatoria Sistémica , Adolescente , Anticuerpos Antivirales/sangre , /diagnóstico , Niño , Preescolar , Estudios Transversales , Femenino , Francia/epidemiología , Humanos , Lactante , Recién Nacido , Masculino , Paris , Estaciones del Año , Pruebas Serológicas/métodos , Glicoproteína de la Espiga del Coronavirus
5.
Artículo en Inglés | MEDLINE | ID: mdl-33807787

RESUMEN

The COVID-19 pandemic put clinical research in the media spotlight globally. This article proposes a first measure of familiarity with and attitude toward clinical research in France. Drawing from the "Health Literacy Survey 2019" (HLS19) conducted online between 27 May and 5 June 2020 on a sample of the French adult population (N = 1003), we show that a significant proportion of the French population claimed some familiarity with clinical trials (64.8%) and had positive attitudes (72%) toward them. One of the important findings of this study is that positive attitudes toward clinical research exist side by side with a strong distancing from the pharmaceutical industry. While respondents acknowledged that the pharmaceutical industry plays an important role in clinical research (68.3%), only one-quarter indicated that they trust the industry (25.7%). Positive attitudes toward clinical trials were associated with familiarity with clinical trials (Odds Ratio, OR 2.97 [1.90-4.63]), financial difficulties (OR 0.63 [0.46-0.85]), as well as mistrust of doctors (0.48 [0.27-0.85]) and of scientists (OR 0.62 [0.38-0.99]). Although the French media provided a great deal of information on how clinical research works during the first months of the pandemic, there remains profound mistrust of the pharmaceutical industry in France. This suspicion can undermine crisis management, especially in the areas of vaccine development and preparation for future pandemics.


Asunto(s)
Pandemias , Adulto , Actitud , Ensayos Clínicos como Asunto , Estudios Transversales , Francia/epidemiología , Humanos , Encuestas y Cuestionarios
6.
Anticancer Res ; 41(4): 2071-2078, 2021 Apr.
Artículo en Inglés | MEDLINE | ID: mdl-33813416

RESUMEN

BACKGROUND/AIM: FOLFOX (5-Fluorouracile and oxaliplatin) exhibits promising activity in advanced well-differentiated neuroendocrine tumors (NETs). This retrospective study aimed to analyze the outcome of metastatic enteropancreatic NETs patients treated with FOLFOX. PATIENTS AND METHODS: We retrospectively identified patients treated with FOLFOX for NETs of enteropancreatic or unknown origin among those referred to our Regional Multidisciplinary Tumor Board. RESULTS: Among 48 patients, most often pancreatic NETs (n=33, 68.8%), the median Ki67 index was 10%. The median number cycle of FOLFOX was 6 and median follow-up was 34.8 months. Disease control rate (DCR) was 83.3%. Median PFS and OS were 12.6 and 29.4 months respectively. Median chemotherapy break was 14.1 months. No significant difference was observed between PFS and the following criteria: Ki67 index, primary tumor site, alkaline phosphatase levels, primary tumor surgery and 18F-FDG PET positivity. CONCLUSION: FOLFOX exhibits a high DCR and a short duration of treatment with a relative long chemotherapy break in patients with metastatic enteropancreatic NETs.


Asunto(s)
Protocolos de Quimioterapia Combinada Antineoplásica/uso terapéutico , Neoplasias Intestinales/tratamiento farmacológico , Tumores Neuroendocrinos/tratamiento farmacológico , Neoplasias Pancreáticas/tratamiento farmacológico , Adulto , Anciano , Anciano de 80 o más Años , Femenino , Fluorouracilo/uso terapéutico , Francia/epidemiología , Humanos , Neoplasias Intestinales/mortalidad , Neoplasias Intestinales/patología , Leucovorina/uso terapéutico , Masculino , Persona de Mediana Edad , Metástasis de la Neoplasia , Tumores Neuroendocrinos/mortalidad , Tumores Neuroendocrinos/patología , Compuestos Organoplatinos/uso terapéutico , Neoplasias Pancreáticas/mortalidad , Neoplasias Pancreáticas/patología , Estudios Retrospectivos , Análisis de Supervivencia , Resultado del Tratamiento , Adulto Joven
7.
Artículo en Inglés | MEDLINE | ID: mdl-33801095

RESUMEN

This study investigated the difficulties experienced by people suffering from depression in coping with the stressful context of the COVID-19 pandemic and the lockdown. Two large samples of the French population were classified on the basis of their depressive symptoms and completed an online questionnaire on their emotions and their behaviors during the lockdown. Results showed that, compared to participants with no or mild mental health-related symptoms, participants with moderate to severe depressive symptoms suffered from greater psychological effects of the pandemic and the lockdown (fear, anxiety, sadness, sleep quality, loss of daily routine). However, health risk behaviors (smoking, drinking, non-compliance with lockdown and barrier gestures) and perceived vulnerability did not differ between the participant groups, although more severely depressed participants tended to be less respectful of health guidelines. In addition, the most heightened effects on the depressed participants were boredom and the feeling of social isolation, which was not compensated by the search for social affiliation. Supporting people with depression should be a public health priority because they suffer psychologically more than others from the pandemic and the lockdown.


Asunto(s)
Pandemias , Adulto , Ansiedad , Control de Enfermedades Transmisibles , Depresión/epidemiología , Francia/epidemiología , Humanos
9.
Soins ; 66(853): 16-21, 2021 Mar.
Artículo en Francés | MEDLINE | ID: mdl-33775295

RESUMEN

The concept of advanced practice nursing and the way it has been adapted to the French context are still poorly understood. It is however rooted in a long history and is based on well-established international notions. After a phase of structuring, advanced practice nurses are now being deployed across the country, with their missions, their association and their own union. Two years after the first graduations, challenges remain but the future is promising.


Asunto(s)
Enfermería de Práctica Avanzada , Francia , Humanos
10.
Soins ; 66(853): 26-27, 2021 Mar.
Artículo en Francés | MEDLINE | ID: mdl-33775297

RESUMEN

Le système de santé français reste à ce jour encore trop médico-centré Une véritable révolution doit s'opérer afin de le faire évoluer, nécessitant de revoir nos schémas de pensée habituels et d'intégrer les évolutions technologiques telles que l'intelligence artificielle D'autres acteurs peuvent y contribuer, comme les infirmiers en pratique avancée, grâce à une formation solide et une volonté politique forte.


Asunto(s)
Prestación de Atención de Salud , Reforma de la Atención de Salud , Prestación de Atención de Salud/organización & administración , Francia , Humanos
11.
Soins ; 66(853): 28-29, 2021 Mar.
Artículo en Francés | MEDLINE | ID: mdl-33775298

RESUMEN

The French association of advanced practice nurses (anfipa) is actively participating in setting up advanced practice across the country. Colleges are places of interaction and work for advanced practice nurses and students. Highlighting missions of this college enables us to create places of discussion and exchanges in the field, and to take part in the rollout of this new profession.


Asunto(s)
Enfermería de Práctica Avanzada , Sociedades de Enfermería , Enfermería de Práctica Avanzada/organización & administración , Francia , Humanos , Trasplante de Riñón/enfermería , Diálisis Renal/enfermería , Insuficiencia Renal Crónica/enfermería , Universidades
12.
Soins ; 66(853): 39-42, 2021 Mar.
Artículo en Francés | MEDLINE | ID: mdl-33775302

RESUMEN

The first challenge, after graduating as an advanced practice nurse is to establish a new model of care in one's place of practice. The feedback from the creation of an advanced practice nurse position in oncology in Amiens-Picardie university hospital, using a population-based approach, illustrates the roles and skills required in this new health profession.


Asunto(s)
Enfermería de Práctica Avanzada/organización & administración , Geriatría , Oncología Médica , Neoplasias , Anciano , Francia , Geriatría/organización & administración , Hospitales Universitarios , Humanos , Oncología Médica/organización & administración , Neoplasias/enfermería
13.
Soins ; 66(853): 46-51, 2021 Mar.
Artículo en Francés | MEDLINE | ID: mdl-33775304

RESUMEN

Abroad, advanced practice in emergency medicine has had positive effects on populations. In France, following the reform of emergency departments, advanced practice nurses in emergency medicine will become a reality. This new profession raises certain fears. Their contribution must be alongside the patients and in the organisations. For this, patient pathways need to be identified and cooperation between the advanced practice nurses and emergency room doctors must be established.


Asunto(s)
Enfermería de Práctica Avanzada , Servicio de Urgencia en Hospital , Rol de la Enfermera , Servicio de Urgencia en Hospital/organización & administración , Francia , Humanos , Rol de la Enfermera/psicología
14.
Soins ; 66(852): 35-37, 2021.
Artículo en Francés | MEDLINE | ID: mdl-33750556

RESUMEN

The COVD-19 wave of spring 2020 had a major impact on French intensive care departments. The intense activity, the support of reinforcements in the acquisition of the necessary skills and their capacity to adapt made intensive care nurses key players in this crisis. Grouped together within the French National Federation of Intensive Care Nurses, they are campaigning to have the specificity of their practice to be recognised and for the creation of certified training in order to meet public healthcare needs not currently fulfilled.


Asunto(s)
/enfermería , Enfermería de Cuidados Críticos , Unidades de Cuidados Intensivos/estadística & datos numéricos , Enfermeras y Enfermeros/psicología , /epidemiología , Epidemias , Francia/epidemiología , Humanos , Pandemias/prevención & control
15.
Global Health ; 17(1): 29, 2021 03 22.
Artículo en Inglés | MEDLINE | ID: mdl-33752717

RESUMEN

BACKGROUND: The impact of general population lockdown implemented in the face of the COVID-19 epidemic needs to be evaluated. We describe here a longitudinal study on the mental health of adults in France. METHODS: We did a secondary analysis of a web-based cohort, initially set up to study home and leisure injuries, in order to measure the consequences of the national lockdown implemented in France from 17 March 2020 to 11 May 2020, and to assess potential vulnerability and resilience factors. Eligible participants were invited to answer an online questionnaire designed to assess their living conditions and health during lockdown. Comparisons were done with answers provided 4.8 years earlier on average. RESULTS: On 15th April 2020, we sent email invitations to 9598 participants recruited between November 2014 and December 2019 and 1237 volunteers took part in the study by completing the online questionnaire. The proportion of those with anxiety symptoms markedly increased from 17.3 to 20.1%. The average self-rated level of mental health decreased from 7.77 to 7.58. Women, the elderly and the youngest appeared to be more vulnerable. A small living space (less than 30 m2) was associated with an increase in depression symptoms (PHQ-9 score), and poorer self-rated physical health at recruitment was associated with an increase in anxiety symptoms (GAD-7 score). On the contrary, the average self-rated level of physical health markedly increased from 7.44 to 7.94 between recruitment and lockdown, and the proportion of those who reported a level of 9 or 10 jumped from 25.7% at recruitment to 43.1% during lockdown. CONCLUSIONS: Mental health deteriorated during lockdown in France during the 2020 COVID-19 crisis. Overall, self-rated physical health improved but those who experienced a worse physical health were more likely to report anxiety symptoms.


Asunto(s)
Ansiedad/epidemiología , Depresión/epidemiología , Salud Mental/estadística & datos numéricos , Cuarentena/psicología , Adulto , Anciano , Anciano de 80 o más Años , Femenino , Francia/epidemiología , Humanos , Estudios Longitudinales , Masculino , Persona de Mediana Edad , Encuestas y Cuestionarios , Adulto Joven
16.
Sci Total Environ ; 764: 142921, 2021 Apr 10.
Artículo en Inglés | MEDLINE | ID: mdl-33757243

RESUMEN

Coastal areas are final recipients of various contaminants including pesticides. The effects of pesticides on non-target organisms are often unclear, especially at environmentally relevant concentrations. This study investigated the impacts of insecticide imidacloprid (IMI) and fungicide propiconazole (PRO), some of the most detected pesticides in the Arcachon Bay in France. This work also included the research of propiconazole nanoformulation (nanoPRO). The effects were assessed studying the development of the early life stages of the Pacific oyster (Magallana gigas). Oyster embryos were exposed for 24, 30, and 42 h (depending on the endpoint) at 24 °C to environmentally relevant concentrations of the two pesticides as well as to nanoPRO. The research focused on sublethal endpoints such as the presence of developmental malformations, alterations of locomotion patterns, or changes in the gene expression levels. No developmental abnormalities were observed after exposure to environmental concentrations detected in the Arcachon Bay in recent years (maximal detected concentration of IMI and PRO were 174 ng/L and 29 ng/L, respectively). EC50 of PRO and nanoPRO were comparable, 2.93 ±â€¯1.35 and 2.26 ±â€¯1.36 mg/L, while EC50 of IMI exceeded 200 mg/L. IMI did not affect larval behavior. PRO affected larval movement trajectory and decreased average larvae swimming speed (2 µg/L), while nanoPRO increased the maximal larvae swimming speed (0.02 µg/L). PRO upregulated especially genes linked to reactive oxygen species (ROS) production and detoxification. NanoPRO effects on gene expression were less pronounced - half of the genes were altered in comparison with PRO. IMI induced a strong dose-response impact on the genes linked to the detoxification, ROS production, cell cycle, and apoptosis regulation. In conclusion, our results suggest that current pesticide concentrations detected in the Arcachon Bay are safe for the Pacific oyster early development, but they might have a small direct effect via altered gene expressions, whose longer-term impacts cannot be ruled out.


Asunto(s)
Crassostrea , Contaminantes Químicos del Agua , Animales , Biomarcadores , Francia , Expresión Génica , Larva , Neonicotinoides , Nitrocompuestos , Triazoles , Contaminantes Químicos del Agua/toxicidad
17.
Rev Infirm ; 70(269): 26-27, 2021 Mar.
Artículo en Francés | MEDLINE | ID: mdl-33742588

RESUMEN

At the Jean-Minjoz regional University Hospital Center in Besançon (25), the therapeutic education of patients with heart failure is carried out by a multidisciplinary team. The education nurse conducts the individual interview. The COVID-19 epidemic has changed the organization of care. Tele-monitoring is becoming the norm, the service nurse contacts patients by telephone and registers them on one of the platforms after they have given their agreement.


Asunto(s)
Insuficiencia Cardíaca , Educación del Paciente como Asunto , Telemedicina , /epidemiología , Francia/epidemiología , Insuficiencia Cardíaca/enfermería , Hospitales Universitarios , Humanos
18.
Arq Neuropsiquiatr ; 79(2): 173-174, 2021 02.
Artículo en Inglés | MEDLINE | ID: mdl-33759985

RESUMEN

Jean-Martin Charcot's (1825-1893) concepts of hysteria evolved significantly over the last 20 years of his career. In the "Leçons du Mardi à la Salpêtrière" (Tuesday lessons), his original conception of a "dynamic lesion" coexists alongside a new psychological conception, sometimes in a rather contradictory way. According to the hand-written transcript of his Tuesday lesson on February 21st, 1888, Charcot stated: "Hysteria must be taken for what it is: psychic disease par excellence". However, in the printed edition of the Tuesday lessons, this emphasis on psychological factors was very much softened. The different wording and corresponding shift in meaning implicitly retrieved Charcot's former conception of a "dynamic lesion". Charcot himself had probably been made aware of the different wording by the editors, and had agreed upon it. After several years of studying this condition, Charcot was probably not confident enough in making too assertive conclusions on the psychological mechanisms underlying hysteria.


Asunto(s)
Histeria , Neurología , Francia , Historia del Siglo XIX , Humanos
19.
Front Public Health ; 9: 620770, 2021.
Artículo en Inglés | MEDLINE | ID: mdl-33748065

RESUMEN

Various measures have been taken in different countries to mitigate the Covid-19 epidemic. But, throughout the world, many citizens don't understand well how these measures are taken and even question the decisions taken by their government. Should the measures be more (or less) restrictive? Are they taken for a too long (or too short) period of time? To provide some quantitative elements of response to these questions, we consider the well-known SEIR model for the Covid-19 epidemic propagation and propose a pragmatic model of the government decision-making operation. Although simple and obviously improvable, the proposed model allows us to study the tradeoff between health and economic aspects in a pragmatic and insightful way. Assuming a given number of phases for the epidemic (namely, 4 in this paper) and a desired tradeoff between health and economic aspects, it is then possible to determine the optimal duration of each phase and the optimal severity level (i.e., the target transmission rate) for each of them. The numerical analysis is performed for the case of France but the adopted approach can be applied to any country. One of the takeaway messages of this analysis is that being able to implement the optimal 4-phase epidemic management strategy in France would have led to 1.05 million of infected people and a GDP loss of 231 billions € instead of 6.88 millions of infected and a loss of 241 billions €. This indicates that, seen from the proposed model perspective, the effectively implemented epidemic management strategy is good economically, whereas substantial improvements might have been obtained in terms of health impact. Our analysis indicates that the lockdown/severe phase should have been more severe but shorter, and the adjustment phase occurred earlier. Due to the natural tendency of people to deviate from the official rules, updating measures every month over the whole epidemic episode seems to be more appropriate.


Asunto(s)
Control de Enfermedades Transmisibles/economía , Análisis Costo-Beneficio/economía , Toma de Decisiones , Gobierno , Modelos Estadísticos , /economía , Francia/epidemiología , Estado de Salud , Humanos , Cuarentena , Factores de Tiempo
20.
Lancet Public Health ; 6(4): e192, 2021 04.
Artículo en Inglés | MEDLINE | ID: mdl-33773633

Asunto(s)
Francia , Humanos
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