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1.
Can Bull Med Hist ; 39(1): 72-98, 2022 04.
Artículo en Inglés | MEDLINE | ID: mdl-35506601

RESUMEN

Thirteen Canadians obtained a doctoral degree from the Faculty of Medicine of Paris between 1822 and 1905. Their studies in France played a decisive role in some of the major trends of 19th-century Canadian history: the formation of a French-Canadian professional bourgeoisie, the formalization of diplomatic ties between Canada and France, the development of bacteriology in America, and the rise of French-Canadian nationalism at the turn of the 20th century. This article traces the careers of these medical doctors by using unpublished sources, mainly their student files and doctoral theses, located through the Pierre Moulinier database and made available by the Bibliothèque Interuniversitaire de Santé of the Université Paris-Descartes. By examining these doctors' travels to Paris, it shows the impact on the Canadian medical profession of the relationship between a former North American colony and its former imperial capital.


Treize Canadiens sont reçus docteurs à la Faculté de médecine de Paris entre 1822 et 1905. Leurs séjours en France jouent un rôle déterminant dans certaines tendances majeures de l'histoire canadienne du XIXe siècle, notamment la formation d'une bourgeoisie professionnelle canadienne-française, l'officialisation des liens diplomatiques entre le Canada et la France, l'essor de la bactériologie en Amérique et la montée du nationalisme canadien-français au tournant du XXe siècle. Grâce à des sources inédites, principalement les dossiers étudiants et les thèses doctorales recueillis dans le fichier Pierre Moulinier de la Bibliothèque Interuniversitaire de Santé de l'Université Paris-Descartes, cet article retrace les parcours de ces docteurs canadiens. En s'attardant à leurs séjours à Paris, il examine les effets sur la profession médicale des rapports entre une ancienne colonie d'Amérique du Nord et sa première capitale impériale.


Asunto(s)
Medicina , Médicos , Canadá , Francia , Humanos , Médicos/historia
2.
BMC Vet Res ; 18(1): 163, 2022 May 04.
Artículo en Inglés | MEDLINE | ID: mdl-35509073

RESUMEN

BACKGROUND: Nowadays, more people are treating dogs as family members. This reflects their increased attention towards their nutrition, with renewed interest for non-conventional diets such as Biologically Appropriate Raw Food/ Bones and Raw Food in United States (BARF) or homemade. In previous studies, owners feeding their dog non-conventional diets reported lower levels of trust in veterinary advice. The aim of the study was to identify differences in lifestyle between owners feeding dogs non-conventional diets and those feeding conventional diets (i.e., dry/wet pet food) to give further insight for improving communication between veterinarians and owners. RESULTS: A total of 426 surveys were usable. Fifteen percent of the participants lived in the metropole of Paris and had more than one dog (mean 1.72 dogs). Thirty-eight percent of the survey respondents stated that their dogs were fed exclusively with non-conventional diets, while 55% declared using conventional diets alone (not considering treats). The study canine population was for the most part neutered (63%) and purebred (68%). Amongst owners feeding conventional diets exclusively, 47% determined how much food to feed by consulting the feeding guidelines on the packaging, and only 28% said that the amount of food was prescribed by their veterinarian or veterinary nurse. Out of the participants feeding non-conventional diets, 65% declared that the information for formulating the recipes was gathered on the internet or in non-veterinary books. When compared with owners feeding exclusively conventional diets, those feeding non-conventional diets were living more frequently outside the metropole of Paris, had fewer children (0.23 ± 0.57 vs 0.37 ± 0.78; p = 0.03) and had more frequently other animals. They also dewormed less often their pets, walked their dog more each day (91 vs 78%; p < 0.001) and without leash for more than 6 h per week (46 vs 31%; p = 0.003). CONCLUSIONS: This survey described differences in the habits of owners feeding dogs non-conventional diets in comparison with those feeding conventional diets. Data suggest that owners using non-conventional diets may be more attentive to the ethological needs of their dog which could be a starting point for practitioners for achieving better client-veterinarian communication.


Asunto(s)
Alimentación Animal , Veterinarios , Alimentación Animal/análisis , Animales , Dieta/veterinaria , Perros , Francia , Humanos , Mascotas , Encuestas y Cuestionarios , Estados Unidos
3.
BMC Prim Care ; 23(1): 82, 2022 04 18.
Artículo en Inglés | MEDLINE | ID: mdl-35436865

RESUMEN

BACKGROUND: In France, the first COVID-19-related lockdown (17th March to 10th May 2020) resulted in a major decrease in healthcare service utilization. This raised concerns about the continuity of care for vulnerable patients. OBJECTIVES: To identify individual and organizational factors associated with the initiatives taken by French GPs to contact vulnerable patients during the lockdown. METHODS: A national observational survey using an online questionnaire was conducted to document French GPs' adaptations to the COVID-19 situation, their individual and organizational characteristics, including practice type (individual, group, multidisciplinary) and size. Data were collected from 7th to 20th May 2020 using mailing lists of GPs from the study partners and GPs who participated in a previous survey. This paper analysed answers to the question exploring whether and how GPs took initiatives to contact vulnerable patients. Responses were categorized in: no initiative; selection of patients to contact with a criteria-based strategy; initiative of contact without criteria-based strategy. Multivariate multinomial logistic regression identified factors associated with each category. Key components of the reported initiatives were described by inductive analysis of verbatim material. RESULTS: Among the 3012 participant GPs (~ 5.6% of French GPs), 1419 (47.1%) reported initiatives to contact some patients without criteria-based strategy, and 808 (26.8%) with a strategy using various clinical/psychological/social criteria. Women GPs more often declared initiatives of contacts with a criteria-based strategy (OR = 1.41, 95% CI [1.14-1.75]) as well as GPs with more than two patients who died due to COVID-19 in comparison with those having none (OR = 1.84, 95% CI [1.43-2.36]). Teaching GPs more often used criteria-based strategies than the other GPs (OR = 1.94, 95% CI [1.51-2.48]). Compared with those working in small monodisciplinary practice, GPs working alone were less likely to implement criteria-based initiatives of contacts (OR = 0.70, 95% CI [0.51-0.97]), while GPs working in multidisciplinary practice were more likely (OR = 1.94, 95% CI [1.26-2.98] in practices > 20 professionals). CONCLUSION: French GPs took various initiatives to keep in touch with vulnerable patients, more frequently when working in group practices. These findings confirm the importance of primary care organization to ensure continuity of care for vulnerable people.


Asunto(s)
COVID-19 , Médicos Generales , COVID-19/epidemiología , Control de Enfermedades Transmisibles , Femenino , Francia/epidemiología , Humanos , Encuestas y Cuestionarios
4.
Vet Parasitol Reg Stud Reports ; 30: 100724, 2022 05.
Artículo en Inglés | MEDLINE | ID: mdl-35431062

RESUMEN

Alveolar echinococcosis is a severe, potentially fatal, parasitic disease caused by ingestion of microscopic eggs of Echinococcus multilocularis. The lifecycle of the parasite is essentially sylvatic, and based on a prey-predator relationship between red foxes and small rodents. A westward expansion from the eastern historical focus has been reported in France, though the parasite has also been detected in the southern Alps. While the focus in the Auvergne region (central France) was described in the 1980s, the southern delimitation of the actual endemic area, especially in the south, was unknown in the absence of dedicated surveys. Red fox samples were collected from 2013 to 2020 in the framework of other transversal epidemiological studies in five sampling areas from southwestern and southeastern France. One hundred and seven intestines were analysed by SSCT, and 221 faecal samples from intestines were analysed by copro-qPCR. None of the 328 foxes exhibited E. multilocularis worms or DNA. Although the presence of E. multilocularis cannot be totally excluded in the departments from the study areas, the sample size tested argues for an absence of the parasite in these studied areas, which is in accordance with the currently known endemic situation in France. These new data are helpful in determining the southernmost limit of E. multilocularis distribution in France. The warm, dry Mediterranean climate in the southeastern areas is less favourable to the transmission of E. multilocularis and especially to the survival of eggs in the environment than the climate in the French Alps or Liguria (Italy) climate where the parasite is present. The intermediate area between the southwestern study areas and the historical focus of Auvergne, which is separated by around 150 km, will be investigated in the coming years. Moreover, an ongoing national surveillance programme on E. multilocularis in foxes is targeting French departements along the edge of the known endemic area both in the southeast and southwest. The data produced will supplement the results of this study, thus greatly helping to define the current distribution of E. multilocularis in France and to target prevention measures to reduce human exposure.


Asunto(s)
Equinococosis , Echinococcus multilocularis , Parásitos , Animales , Equinococosis/epidemiología , Equinococosis/parasitología , Equinococosis/veterinaria , Zorros/parasitología , Francia/epidemiología
5.
Sante Publique ; Vol. 33(6): 1011-1021, 2022 Mar 11.
Artículo en Francés | MEDLINE | ID: mdl-35485003

RESUMEN

The crisis linked to COVID-19 has shaken up the organization of healthcare in France, particularly its administration. However, little is known about the crisis management action by the regional health agencies (ARS), at the crisis' forefront.Based on an internal feedback exercise, thanks to a qualitative method dealing with cross-referencing documentary sources and semi-structured interviews (90), this monograph reports on the regional management of the COVID-19 crisis of an administrative organization over the first half of 2020 by analyzing the temporal and organizational dynamics of crisis management, the role of this public authority, the public health strategies mobilized to tackle the epidemic in interaction with regional and national actors.From January to June 2020, COVID-19 management has been characterized by the sudden disruption of the usual benchmarks and agendas of priorities and by an unusual installation over time. The agency found itself in a permanent adaptation-reaction situation, setting up an ad hoc crisis management organization. It positioned itself as a key player, interacting with various actors and relying upon a wide range of public policy tools to do so.This monograph highlights the management of a recent and unprecedented social and healthcare crisis which questions usual health management knowledge and skills, at national and regional levels in France. It demonstrates the interest of crisis feedback discussions, with both internal and heuristic objectives.


Asunto(s)
COVID-19 , Atención a la Salud , Francia/epidemiología , Humanos , Salud Pública
6.
Sante Publique ; Vol. 33(6): 823-827, 2022 Mar 11.
Artículo en Francés | MEDLINE | ID: mdl-35485012

RESUMEN

This contribution presents the dynamics generated by the COVID-19 pandemic since March 2020 in the humanities and social sciences (SHS) in France. It first describes the main elements of the individual and institutional involvement that give this dynamic the characteristics of an "extra-ordinary" mobilization. Based on a collective research report, it goes on presenting the research themes and issues, as well as the methodological and epistemological reflections put forward by the SHS on the subject of the pandemic and its management. This contribution thus gives an account of the way in which the SHS participate in a social and political understanding of health issues. By carrying out research themes and issues that are sometimes new and sometimes deeply rooted in the scientific capital that is theirs concerning health and environmental crises, the SHS bring their contribution to the description and the analysis of the foundations and consequences of these crises on individuals and societies: knowledge likely to enlighten public decision-making.


Asunto(s)
COVID-19 , Pandemias , Francia/epidemiología , Humanidades , Humanos , Ciencias Sociales
7.
Sante Publique ; Vol. 33(6): 835-841, 2022 Mar 11.
Artículo en Francés | MEDLINE | ID: mdl-35485014

RESUMEN

INTRODUCTION: The challenges of communicating with the population during a health crisis are multiple, with the ultimate objective of getting as many people as possible to apply preventive measures. AIM: The objective of this article is to present the results of an evaluation of the communication contents on COVID-19 prevention broadcast by Santé publique France (the national public health agency) on March 2020, for the general population. Two studies, one quantitative and one qualitative, were carried out during the first lockdown. The "Coronavirus Alert" communication campaign then included four media contents (spots and posters) describing health protective behaviors and signs of the disease. RESULTS: Recall of the campaign was particularly high, with nine in ten spontaneously citing messages from the campaign. Over 90% found it easy to understand and useful, although 20% found it induced anxiety. The declared impact on behavior was also very high, with 97% of people affirming to be encouraged by the media contents to implement health protective behaviors. There was, however, lower adherence to the campaign among men and low-income people.The qualitative study clarified some of the results: the clarity of the materials was attributed to the pictograms illustrating the health protective behaviors, and the tone of the spots was judged appropriate to the seriousness of the health situation. CONCLUSION: These studies highlight significant exposure to the supports tested and a positive perception of them. Their lessons were useful in continuing the dissemination of the health protection tools produced by Santé publique France.


Asunto(s)
COVID-19 , COVID-19/prevención & control , Control de Enfermedades Transmisibles , Comunicación , Femenino , Francia , Humanos , Masculino , Salud Pública
8.
Sante Publique ; Vol. 33(6): 923-934, 2022 Mar 11.
Artículo en Francés | MEDLINE | ID: mdl-35485024

RESUMEN

INTRODUCTION: The COVID-19 epidemic represented a major challenge for the primary care sector. We present the results of an interprofessional collaborative research endeavor conducted by the ACCORD network to describe primary care actors' and organizations' response to the first wave of the epidemic and national lockdown in France. METHODS: This work draws from quantitative and qualitative material. The quantitative data results from the cross-analysis of the six online surveys carried out by the ACCORD network between March and May 2020, among general practitioners, midwives, and multi-professional primary care organizations in France. This data was enriched by collective multi-professional and multi-disciplinary exchanges conducted in virtual focus groups during an online seminar. RESULTS: There was a significant decrease in primary care activity during the first wave of the epidemic. Many primary care actors adapted their organizations to lower the risk of coronavirus transmission while maintaining access and continuity of care. Professionals received and used information from multiple sources. The crisis revealed both the importance and the diversity of local networks of exchange and collaboration. CONCLUSIONS: Primary care actors adapted quickly and with important local variability to the COVID epidemic, highlighting the importance of pre-existing organizations and collaborations at the local level.


Asunto(s)
COVID-19 , COVID-19/epidemiología , Control de Enfermedades Transmisibles , Francia/epidemiología , Humanos , Atención Primaria de Salud , Investigadores
9.
Sante Publique ; Vol. 33(6): 991-995, 2022 Mar 11.
Artículo en Francés | MEDLINE | ID: mdl-35485030

RESUMEN

INTRODUCTION: Facing COVID-19, most of health care system first responded with the confinement of the population and an increase of intensive care resources. Primary care was then mobilized variably and more or less coordinated. PURPOSE OF RESEARCH: Comparing the involvement of primary care in four francophone regions with similar primary care to draw lessons for reforms directions in light of the COVID experience. RESULTS: Mobilization of primary care actors was important, heterogeneous and linked to local context and previous dynamics at the territorial level or the practice level except in Quebec where primary care is governed by health authorities. The creation of COVID centers was systematic as "warm practices" in Quebec or left to the initiative of local stakeholders more or less supported by health authorities. Teleconsultation, largely dominated by the use of the telephone, was implemented everywhere, generally supported by flexible and adapted pricing. The performance of diagnostic tests such as vaccination by new professionals within a legal, financial and simple training framework is a major area for improvement. Information systems to assess local needs were insufficient everywhere. CONCLUSION: The definition of primary care governance methods and, in particular, the link between professionals and public health operators in the four areas studied is a priority area for improvement at both local and national levels.


Asunto(s)
COVID-19 , Bélgica , COVID-19/epidemiología , Francia/epidemiología , Humanos , Atención Primaria de Salud , Quebec/epidemiología , Suiza
10.
Sante Publique ; Vol. 33(6): 997-1003, 2022 Mar 11.
Artículo en Francés | MEDLINE | ID: mdl-35485031

RESUMEN

AIM: The COVID-19 outbreak is likely to affect both the occurrence and the reporting of abuse or neglect in vulnerable adults in a variety of ways. This study aims to explore such effects based on the alerts reported to the national system dedicated to these situations by the Ministry of Solidarity and Health in France. METHOD: The main characteristics of the situations of abuse or neglect (age and gender of the victims, main type of abuse or neglect, persons considered as responsible, place of occurrence) reported to the national system from March to December 2020, since the beginning of the COVID-19 outbreak, have been compared to those observed during the same months from 2017 to 2019. RESULTS: In 2019-20, abuses or neglects in nursing homes decreased (-111 or -8%), during 3-months, while those reported in domestic situations increased slightly (+50 or +1%), despite a short decline at the beginning of the epidemic. The situations reported during the epidemic as compared to those of the three previous years affected more often women, and less often involved persons other than families or professionals. Violations of rights, and psychological abuses have been more frequent, financial abuses and neglects have been less frequent since the beginning of the outbreak.


Asunto(s)
COVID-19 , Epidemias , Adulto , COVID-19/epidemiología , Brotes de Enfermedades , Femenino , Francia/epidemiología , Humanos
11.
Rech Soins Infirm ; (147): 17-26, 2022 Feb 10.
Artículo en Francés | MEDLINE | ID: mdl-35485032

RESUMEN

Context : Nurses are regularly confronted with suicidal people. Their involvement is essential in the detection and prevention of suicide risk.Objectives : Through a literature review, we wanted to highlight the role of the advanced practice nurse by conducting specific training to improve nursing skills in the management of people with suicidal thoughts.Method : Our literature review was carried out according to the PRISMA recommendation criteria from several databases.Results : The review showed an improvement in confidence, attitudes, and nursing skills in assessing suicide risk. However, no long-term change in practice was demonstrated.Discussion : In France, a national training program on suicide risk prevention is implemented at the regional level by the Regional Health Agencies. At the same time, since 2019, Psychiatry and Mental Health has been part of the training program for advanced practice nurses.Conclusion : The advanced practice nurse is a central player in supporting teams in increasing their skills, particularly when conducting specific training.


Asunto(s)
Enfermería de Práctica Avanzada , Suicidio , Francia , Humanos , Suicidio/prevención & control , Suicidio/psicología
12.
J Int Bioethique Ethique Sci ; Vol. 32(4): 127-149, 2022 Mar 09.
Artículo en Francés | MEDLINE | ID: mdl-35485044

RESUMEN

One of the biggest issues faced by lawmakers in the news revolves around the question of how to deal with the scientific discoveries uncovered by new technologies. Scientific developments in the field of health awaken, in human beings, the desire to try to go beyond nature, and developments in the field of sexual and reproductive health not only challenge the laws of nature itself, but also the laws put in place by humanity. Among the advances in the field of human contraception, we highlight voluntary sterilization, used throughout the world as a 99% effective contraceptive measure. In Brazil, voluntary sterilization was formalized by the Family Planning Law which imposed, among other restrictions, the need for the consent of another person for its realization. It is a violent imposition, in the service of control over the bodies, on the part of the State. This control is notably imposed on the woman’s body, thus reducing her autonomy, which is the basis of her dignity. That said, the purpose of this article is to question the foundations on which the adoption of such a limitation of bodily self-determination is based and justified. For this, the legal-philosophical contributions of authors Ronald Dworkin and Jürgen Habermas will be examined, in the light of bioethics. The focus of the questions will be on the analysis of the ways in which Brazil and France have welcomed the process of voluntary sterilization, and what have been the most important consequences of this legalization.


Asunto(s)
Servicios de Planificación Familiar , Esterilización Reproductiva , Brasil , Femenino , Francia , Humanos
13.
J Int Bioethique Ethique Sci ; Vol. 32(4): 45-71, 2022 Mar 09.
Artículo en Francés | MEDLINE | ID: mdl-35485047

RESUMEN

The objective of this article is to identify ethical recommendations for the deployment of Digital Health in the field of disability. The description of the pioneer years of telemedicine is completed by some figures on disability in France to identify the general context that presides over the foreseeable deployment in the coming years. This deployment is accelerating, boosted by the COVID 19 pandemic, taking into account all the potential of digital technology. In this context, disability has been the poor relation for many years, characterized by numerous obstacles in access to care, as pointed out by multiple reports. The pragmatic response that we suggest at the territorial level involves first of all identifying the needs of disabled people. The analysis will be centered on a population of 57 candidates for admission to a shared housing facility known as inclusive by the Simon de Cyrène association in Rungis. 53% of the candidates were admitted, their profile is described, and we suggest integrating digital tools into the organization of care by taking into account the specificity of the needs and the context of the facility. This framework gives the opportunity to propose ethical recommendations. Candidates who are not admitted must also have access to care, whether they reside in specialized homes, hostels or hospital services. From an ethical perspective, we must ensure that we provide equitable access to care. In practice, the analysis carried out in this study shows the interest of having and applying in Digital Health a charter between the applicants and the required, pivotal or proximity hospital, in the respect of fair care for a population whose deficit of access to care has been widely noted. Ethical recommendations are a key point in this context.


Asunto(s)
COVID-19 , Personas con Discapacidad , COVID-19/epidemiología , Francia , Humanos , Principios Morales
14.
J Hist Dent ; 70(1): 30-46, 2022.
Artículo en Inglés | MEDLINE | ID: mdl-35468052

RESUMEN

Musée de la Cour d'Or, Metz, France, possesses a female skull bearing a gold wire dental appliance claimed in a 1934 Dental Cosmos article on the history of dental prosthetics to be 'probably' Merovingian in origin. Inquiries in 2017 revealed current museum curators were unaware of this claim but were skeptical of such dating suggesting scientific analysis might provide clarity. Carbon dating of a tooth from the skull was carried out placing the artifact in the mid seventeenth-late eighteenth centuries while Metz historical records reveal the find site was occupied by a convent of nuns for most of C14 dated period. Strontium isotopic analysis indicates the woman was a local of the Metz region while fluorine analysis indicates exposure to fluoride early in life. Oral health status and the dentistry indicate the woman was of high social status.


Asunto(s)
Monjas , Isótopos de Estroncio , Huesos , Femenino , Francia , Humanos , Datación Radiométrica
15.
BMC Health Serv Res ; 22(1): 567, 2022 Apr 27.
Artículo en Inglés | MEDLINE | ID: mdl-35477443

RESUMEN

BACKGROUND: In a context where the economic burden of HIV is increasing as HIV patients now have a close to normal lifespan, the availability of generic antiretrovirals commonly prescribed in 2017 and the imminence of patent expiration are expected to provide substantial savings in the coming years. This article aims to assess the economic impact of these generic antiretrovirals in France and specifically over a five-year period. METHODS: An agent-based model was developed to simulate patient trajectories and treatment use over a five-year period. By comparing the results of costs for trajectories simulated under different predefined scenarios, a budget impact model can be created and sensitivity analyses performed on several parameters of importance. RESULTS: The potential economic savings from 2019 to 2023 generated by generic antiretrovirals range from €309 million when the penetration rate of generics is set at 10% to €1.5 billion at 70%. These savings range from €984 million to €993 million as the delay between patent and generic marketing authorisation varies from 10 to 15 years, and from €965 million to €993 million as the Negotiated Price per Unit (NPU) of generics at market-entry varies from 40 to 50% of the NPU for patents. DISCUSSION: This economic savings simulation could help decision makers to anticipate resource allocations for further innovation in antiretrovirals therapies as well as prevention, especially by funding the Pre-Exposure Prophylaxis (PrEP) or HIV screening.


Asunto(s)
Infecciones por VIH , Antirretrovirales/uso terapéutico , Costos de los Medicamentos , Medicamentos Genéricos/uso terapéutico , Francia , Infecciones por VIH/tratamiento farmacológico , Humanos
18.
Pestic Biochem Physiol ; 183: 105052, 2022 May.
Artículo en Inglés | MEDLINE | ID: mdl-35430058

RESUMEN

Rodent control is mainly done using anticoagulant rodenticides leading to the death of rodents through internal bleeding by targeting the VKORC1 protein. However, mutations in VKORC1 can lead to resistance to anticoagulant rodenticides that can cause treatment failure in the field. This study provides the first insight into the distribution, frequency and characterization of Vkorc1 mutations in roof rats (Rattus rattus) in France and in three administrative areas of Spain. The roof rat is present in France while it was thought to have almost disappeared with the expansion of the brown rat. Nevertheless, it has been found mainly in maritime areas. 151 roof rats out of 219 tested presented at least one missense mutation in the coding sequences of Vkorc1 gene (i.e. 69.0% of the rat). Nine Vkorc1 genotypes were detected (Y25F, A26P, R40G, S57F, W59C, W59R, H68N, Y25F/K152T and Y25F/W59R. Biochemical characterization of the consequences of these different genotypes proved that these various genotypes did not induce severe resistance to anticoagulant rodenticides. Even if many mutations of the Vkorc1 gene are present in roof rat populations in France, their management may be based in a first approach, considering the low levels of resistance induced, on the use of first-generation anticoagulants less dangerous for wildlife. The use of second-generation may be considered when treatment failure is observed or when bait consumption is limited.


Asunto(s)
Rodenticidas , Animales , Anticoagulantes/farmacología , Resistencia a Medicamentos/genética , Francia , Mutación , Mutación Missense , Ratas , Rodenticidas/farmacología , España , Vitamina K Epóxido Reductasas/genética
19.
Lancet ; 399(10335): 1583, 2022 04 23.
Artículo en Inglés | MEDLINE | ID: mdl-35461542
20.
BMJ Open ; 12(4): e056503, 2022 Apr 08.
Artículo en Inglés | MEDLINE | ID: mdl-35396295

RESUMEN

OBJECTIVES: To assess the impact on readers' interpretation of the results reported in an abstract for a hypothetical clinical trial with (1) a statistically significant result (SSR), (2) spin, (3) both an SSR and spin compared with (4) no spin and no SSR. PARTICIPANTS: Health students and professionals from universities and health institutions in France and the UK. INTERVENTIONS: Participants completed an online questionnaire using Likert scales and free text, after reading one of the four versions of an abstract about a hypothetical randomised trial evaluating 'Naranex' and 'Bulofil' (two hypothetical drugs) for chronic low back pain. The abstracts differed in (1) reported result of 'mean difference of 1.31 points (95% CI 0.08 to 2.54, p= 0.04)' or 'mean difference of 1.31 points (95% CI -0.08 to 2.70, p= 0.06)' and (2) presence or absence of spin. The effect size for the trial's primary outcome (pain disability score) was the same in each abstract, slightly in favour of Naranex. PRIMARY OUTCOME: The reader's interpretation of the trial's results, based on their answer (1, disagree; 4, neutral; 7, agree) to the following statement: 'About the main findings of the study, what is your opinion about the following statement: 'Naranex is better than Bulofil'?' RESULTS: Two hundred and ninety-seven of the 404 people randomised to receive one of the four abstracts completed the study. Respondents were more likely to favour Narenex when the abstract reported an SSR without spin, a statistically significant result with spin, a non-statistically significant result with spin, compared with when it reported a non-SSR without spin. CONCLUSION: Statistical significance appears to have influenced readers' perception whatever the level of spin, while spin influenced readers' perception when the results were not statistically significant but did not appear to have an impact when results were statistically significant.


Asunto(s)
Lectura , Francia , Humanos , Encuestas y Cuestionarios
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