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1.
Nat Commun ; 11(1): 4829, 2020 09 24.
Artículo en Inglés | MEDLINE | ID: mdl-32973154

RESUMEN

The computed tomography angiography (CTA) postprocessing manually recognized by technologists is extremely labor intensive and error prone. We propose an artificial intelligence reconstruction system supported by an optimized physiological anatomical-based 3D convolutional neural network that can automatically achieve CTA reconstruction in healthcare services. This system is trained and tested with 18,766 head and neck CTA scans from 5 tertiary hospitals in China collected between June 2017 and November 2018. The overall reconstruction accuracy of the independent testing dataset is 0.931. It is clinically applicable due to its consistency with manually processed images, which achieves a qualification rate of 92.1%. This system reduces the time consumed from 14.22 ± 3.64 min to 4.94 ± 0.36 min, the number of clicks from 115.87 ± 25.9 to 4 and the labor force from 3 to 1 technologist after five months application. Thus, the system facilitates clinical workflows and provides an opportunity for clinical technologists to improve humanistic patient care.


Asunto(s)
Angiografía/métodos , Vasos Sanguíneos/diagnóstico por imagen , Cabeza/diagnóstico por imagen , Procesamiento de Imagen Asistido por Computador/métodos , Imagenología Tridimensional/métodos , Cuello/diagnóstico por imagen , Red Nerviosa/diagnóstico por imagen , Anciano , Huesos/diagnóstico por imagen , China , Femenino , Humanos , Masculino , Persona de Mediana Edad , Tomografía Computarizada por Rayos X
2.
Anticancer Res ; 40(10): 5735-5738, 2020 Oct.
Artículo en Inglés | MEDLINE | ID: mdl-32988899

RESUMEN

BACKGROUND/AIM: Surgical staging is paramount to treatment of primary bone sarcomas. Often, bone scintigraphy and/or positron emission tomography-computed tomography (PET-CT) are used to exclude skeletal metastases; however, skeletal metastases in chondrosarcoma are rare. The purpose of this study was to assess the utility of these staging methods in patients with chondrosarcoma. PATIENTS AND METHODS: We reviewed 138 (87 males, 51 female) patients, mean age 54±20 years, with a chondrosarcoma, who had completed a bone scintigraphy or PET/CT as part of surgical staging. Sensitivity, specificity, and positive/negative predictive value of the scans was calculated. RESULTS: Seventeen (12%) patients had a positive bone scintigraphy or PET-CT for skeletal metastases. In cases of bone scintigraphy (n=11), 6 were benign and 5 were skeletal metastases. In cases of PET-CT, 6 were skeletal metastases, 3 were positive and 3 benign. All positive cases regarded dedifferentiated chondrosarcoma. The overall sensitivity and specificity of a bone scan or PET-CT was 100% and 93.1%; with a positive and negative predictive value of 47.1% and 100%, respectively. CONCLUSION: Skeletal metastases at presentation of chondrosarcoma are rare and associated with dedifferentiated chondrosarcoma. Bone scintigraphy or PET-CT should only be performed in cases of high grade and dedifferentiated histology.


Asunto(s)
Neoplasias Óseas/diagnóstico por imagen , Condrosarcoma/diagnóstico por imagen , Tomografía Computarizada por Tomografía de Emisión de Positrones , Cintigrafía , Neoplasias Óseas/patología , Neoplasias Óseas/secundario , Huesos/diagnóstico por imagen , Huesos/patología , Condrosarcoma/patología , Femenino , Fluorodesoxiglucosa F18/administración & dosificación , Humanos , Masculino , Persona de Mediana Edad , Metástasis de la Neoplasia , Tomografía Computarizada por Rayos X
3.
Br J Radiol ; 93(1115): 20200775, 2020 Nov 01.
Artículo en Inglés | MEDLINE | ID: mdl-32880475

RESUMEN

OBJECTIVES: The isotope bone scan (IBS) is the gold-standard imaging modality for detecting skeletal metastases as part of prostate cancer staging. However, its clinical utility for assessing skeletal metastatic burden is limited due to the need for subjective interpretation. We designed and tested a novel custom software tool, the Metastatic Bone Scan Tool (MetsBST), aimed at improving interpretation of IBSs, and compared its performance with that of an established software programme. METHODS: We used IBS images from 62 patients diagnosed with prostate cancer and suspected bone metastases to design and implement MetsBST in MATLAB by defining thresholds used to identify the texture and size of metastatic bone lesions. The results of MetsBST were compared with those of the commercially available automated Bone Scan Index (aBSI) with regression analysis. RESULTS: There was strong agreement between the MetsBST and aBSI results (R2 = 0.9189). In a subregional analysis, MetsBST quantified the extent of metastatic disease in multiple bone sites in patients receiving multimodality therapy (radium-223 and external beam radiotherapy) to illustrate the differences in bone metastatic response to different treatments. CONCLUSION: The results of MetsBST and the commercial software aBSI were highly consistent. MetsBST introduces novel clinical utility by its ability to differentiate between the responses of different bone metastases to multimodality therapies. ADVANCES IN KNOWLEDGE: MetsBST reduces the variability in assessment of tumour burden caused by subjective interpretation. Therefore, it is a useful aid to physicians reporting nuclear medicine scans, and may improve decision-making in the treatment of metastatic prostate cancer.


Asunto(s)
Neoplasias Óseas/diagnóstico por imagen , Neoplasias Óseas/secundario , Huesos/diagnóstico por imagen , Neoplasias de la Próstata/patología , Diseño de Software , Anciano , Anciano de 80 o más Años , Neoplasias Óseas/patología , Neoplasias Óseas/radioterapia , Ácido Etidrónico , Humanos , Masculino , Persona de Mediana Edad , Compuestos de Organotecnecio , Neoplasias de la Próstata Resistentes a la Castración/patología , Radiofármacos , Análisis de Regresión , Carga Tumoral , Vejiga Urinaria/diagnóstico por imagen
4.
BMC Med Genet ; 21(1): 189, 2020 09 29.
Artículo en Inglés | MEDLINE | ID: mdl-32993552

RESUMEN

BACKGROUND: Acroscyphodysplasia has been described as a phenotypic variant of acrodysostosis type 2 and pseudohypoparathyroidism. In acrodysostosis, skeletal features can include brachydactyly, facial hypoplasia, cone-shaped epiphyses, short stature, and advanced bone age. To date, reports on this disorder have focused on phenotypic findings, endocrine changes, and genetic variation. We present a 14-year overview of a patient, from birth to skeletal maturity, with acroscyphodysplasia, noting the significant orthopaedic challenges and the need for a multidisciplinary team, including specialists in genetics, orthopaedics, endocrinology, and otolaryngology, to optimize long-term outcomes. CASE PRESENTATION: The patient presented as a newborn with dysmorphic facial features, including severe midface hypoplasia, malar flattening, nasal stenosis, and feeding difficulties. Radiologic findings were initially subtle, and a skeletal survey performed at age 7 months was initially considered normal. Genetic evaluation revealed a variant in PDE4D and subsequent pseudohypoparathyroidism. The patient presented to the department of orthopaedics, at age 2 years 9 months with a leg length discrepancy, right knee contracture, and severely crouched gait. Radiographs demonstrated cone-shaped epiphyses of the right distal femur and proximal tibia, but no evidence of growth plate changes in the left leg. The child developed early posterior epiphyseal arrest on the right side and required multiple surgical interventions to achieve neutral extension. Her left distal femur developed late posterior physeal arrest and secondary contracture without evidence of schypho deformity, which improved with anterior screw epiphysiodesis. The child required numerous orthopaedic surgical interventions to achieve full knee extension bilaterally. At age 13 years 11 months, she was an independent ambulator with erect posture. The child underwent numerous otolaryngology procedures and will require significant ongoing care. She has moderate intellectual disability. DISCUSSION AND CONCLUSIONS: Key challenges in the management of this case included the subtle changes on initial skeletal survey and the marked asymmetry of her deformity. While cone-shaped epiphyses are a hallmark of acrodysostosis, posterior tethering/growth arrest of the posterior distal femur has not been previously reported. Correction of the secondary knee contracture was essential to improve ambulation. Children with acroscyphodysplasia require a multidisciplinary approach, including radiology, genetics, orthopaedics, otolaryngology, and endocrinology specialties.


Asunto(s)
Disostosis/terapia , Discapacidad Intelectual/terapia , Comunicación Interdisciplinaria , Osteocondrodisplasias/terapia , Grupo de Atención al Paciente , Seudohipoparatiroidismo/terapia , Huesos/anomalías , Huesos/diagnóstico por imagen , Huesos/metabolismo , Subunidad RIalfa de la Proteína Quinasa Dependiente de AMP Cíclico/genética , Fosfodiesterasas de Nucleótidos Cíclicos Tipo 4/genética , Disostosis/diagnóstico , Disostosis/genética , Estudios de Seguimiento , Predisposición Genética a la Enfermedad/genética , Discapacidad Intelectual/diagnóstico , Discapacidad Intelectual/genética , Osteocondrodisplasias/diagnóstico , Osteocondrodisplasias/genética , Seudohipoparatiroidismo/diagnóstico , Seudohipoparatiroidismo/genética , Radiografía/métodos , Factores de Tiempo
5.
Int J Nanomedicine ; 15: 5825-5838, 2020.
Artículo en Inglés | MEDLINE | ID: mdl-32821104

RESUMEN

Background and Purpose: The extracellular matrix (ECM) derived from bone marrow mesenchymal stem cells (BMSCs) has been used in regenerative medicine because of its good biological activity; however, its poor mechanical properties limit its application in bone regeneration. The purpose of this study is to construct a three dimensional-printed hydroxyapatite (3D-HA)/BMSC-ECM composite scaffold that not only has biological activity but also sufficient mechanical strength and reasonably distributed spatial structure. Methods: A BMSC-ECM was first extracted and formed into micron-sized particles, and then the ECM particles were modified onto the surface of 3D-HA scaffolds using an innovative linking method to generate composite 3D-HA/BMSC-ECM scaffolds. The 3D-HA scaffolds were used as the control group. The basic properties, biocompatibility and osteogenesis ability of both scaffolds were tested in vitro. Finally, a critical skull defect rat model was created and the osteogenesis effect of the scaffolds was evaluated in vivo. Results: The compressive modulus of the composite scaffolds reached 9.45±0.32 MPa, which was similar to that of the 3D-HA scaffolds (p>0.05). The pore size of the two scaffolds was 305±47 um and 315±34 um (p>0.05), respectively. A CCK-8 assay indicated that the scaffolds did not have cytotoxicity. The composite scaffolds had good cell adhesion ability, with a cell adhesion rate of up to 76.00±6.17% after culturing for 7 hours, while that of the 3D-HA scaffolds was 51.85±4.77% (p<0.01). In addition, the composite scaffold displayed higher alkaline phosphatase (ALP) activity, osteogenesis-related mRNA expression, and calcium nodule formation, thus confirming that the composite scaffolds had good osteogenic activity. The composite scaffolds exhibited good bone repair in vivo and were superior to the 3D-HA scaffolds. Conclusion: We conclude that BMSC-ECM is a good osteogenic material and that the composite scaffolds have good osteogenic ability, which provides a new method and concept for the repair of bone defects.


Asunto(s)
Durapatita/farmacología , Matriz Extracelular/metabolismo , Células Madre Mesenquimatosas/citología , Andamios del Tejido/química , Animales , Regeneración Ósea/efectos de los fármacos , Huesos/diagnóstico por imagen , Huesos/efectos de los fármacos , Huesos/patología , Adhesión Celular/efectos de los fármacos , Muerte Celular/efectos de los fármacos , Diferenciación Celular/efectos de los fármacos , Matriz Extracelular/efectos de los fármacos , Hidrodinámica , Masculino , Células Madre Mesenquimatosas/efectos de los fármacos , Células Madre Mesenquimatosas/ultraestructura , Osteogénesis/efectos de los fármacos , Osteogénesis/genética , ARN Mensajero/genética , ARN Mensajero/metabolismo , Ratas Sprague-Dawley , Cicatrización de Heridas/efectos de los fármacos
6.
J Med Life ; 13(2): 265-268, 2020.
Artículo en Inglés | MEDLINE | ID: mdl-32742524

RESUMEN

Bone metastases in cholangiocarcinoma are uncommon. We report the case of a patient with disseminated osteolytic lesions who was admitted to the Neurology Department for progressive paraparesis. On the computed tomography examination, specific features for cholangiocarcinoma were described, confirmed later by the histopathological aspect of the bone lesions.


Asunto(s)
Neoplasias de los Conductos Biliares/complicaciones , Colangiocarcinoma/complicaciones , Osteólisis/complicaciones , Paraparesia/complicaciones , Neoplasias de los Conductos Biliares/patología , Neoplasias Óseas/secundario , Huesos/diagnóstico por imagen , Huesos/patología , Colangiocarcinoma/patología , Humanos , Masculino , Osteólisis/diagnóstico por imagen , Paraparesia/diagnóstico por imagen , Tomografía Computarizada por Rayos X
7.
J Am Acad Orthop Surg ; 28(16): e696-e705, 2020 Aug 15.
Artículo en Inglés | MEDLINE | ID: mdl-32769718

RESUMEN

Ultrasonography is a valuable tool that can be used in many capacities to evaluate and treat pediatric orthopaedic patient. It has the capability to depict bone, cartilaginous and soft-tissue structures, and provide dynamic information. This technique can be readily applied to a wide range of pediatric conditions, including developmental dysplasia of the hip, congenital limb deficiencies, fracture management, joint effusions, and many other musculoskeletal pathologies. There are many benefits of implementing ultrasonography as a regular tool. It is readily accessible at most centers, and information can be quickly obtained in a minimally invasive way, which limits the need for radiation exposure. Ultrasonography is a safe and reliable tool that pediatric orthopaedic surgeons can incorporate into the diagnosis and management of a broad spectrum of pathology.


Asunto(s)
Enfermedades Musculoesqueléticas/diagnóstico por imagen , Pediatría , Ultrasonografía/métodos , Adolescente , Enfermedades del Desarrollo Óseo/diagnóstico por imagen , Huesos/diagnóstico por imagen , Cartílago/diagnóstico por imagen , Niño , Preescolar , Tejido Conectivo/diagnóstico por imagen , Fracturas Óseas/diagnóstico por imagen , Cadera/diagnóstico por imagen , Humanos , Lactante , Reproducibilidad de los Resultados , Seguridad
8.
Clin Nucl Med ; 45(10): 824-826, 2020 Oct.
Artículo en Inglés | MEDLINE | ID: mdl-32796243

RESUMEN

Osteosarcoma is usually F-FDG-avid. Here we report a case of an 18-year-old young man with widespread osteoblastic and slight osteolytic changes, which had diffusely increased Ga-DOTATATE uptake in the osseous lesions, whereas the F-FDG PET/CT was unrevealing. The final diagnosis is synchronous multifocal osteosarcoma based on the pathological, clinical, and imaging features.


Asunto(s)
Huesos/diagnóstico por imagen , Progresión de la Enfermedad , Fluorodesoxiglucosa F18 , Compuestos Organometálicos , Osteosarcoma/diagnóstico por imagen , Osteosarcoma/patología , Tomografía Computarizada por Tomografía de Emisión de Positrones , Adolescente , Humanos , Masculino
10.
Medicine (Baltimore) ; 99(27): e21047, 2020 Jul 02.
Artículo en Inglés | MEDLINE | ID: mdl-32629730

RESUMEN

Repair of medial meniscus posterior root tear (MMPRT) is considered as an effective early intervention strategy for osteoarthritis. We aimed at evaluating whether or not single-photon emission computed tomography/computed tomography (SPECT/CT) could predict the treatment outcome.Eleven patients with MMPRT who underwent preoperative SPECT/CT were retrospectively enrolled. Clinical symptoms were evaluated based on the knee injury and osteoarthritis outcome score (KOOS) and visual analogue scale (VAS) for pain. The uptake pattern of the medial tibial plateau (MTP) on SPECT/CT was visually assessed. Additionally, the maximum lesion-to-cortical counts ratio (LCRmax) for the anterior and posterior aspects of MTP and anterior-posterior MTP ratio (APR) were quantitatively assessed. Spearman correlation analyses were performed between the change in clinical symptom scores and preoperative SPECT/CT patterns.All patients showed increased radiotracer uptake in MTP. Among them, 8 (73%) showed dominant uptake in the anterior aspect of MTP. The rest 3 (27%) showed posterior-dominant uptake. Patients with anterior-dominant patterns tended to show better outcomes in terms of the postoperative KOOS score (P = .07). Anterior MTP LCRmax showed a negative correlation with the change in VAS (ρ = -0.664, P < .03). APR showed a correlation with the change in the KOOS score (ρ = 0.655, P < .03).Patients with MMPRT with relatively higher uptake in the anterior aspect of MTP could have better clinical outcomes after the repair. The preoperative SPECT/CT pattern may have a predictive value in selecting patients with good postoperative outcomes.


Asunto(s)
Meniscos Tibiales/patología , Osteoartritis/cirugía , Rotura/cirugía , Tomografía Computarizada por Tomografía Computarizada de Emisión de Fotón Único/métodos , Anciano , Huesos/diagnóstico por imagen , Femenino , Humanos , Traumatismos de la Rodilla/cirugía , Articulación de la Rodilla/diagnóstico por imagen , Meniscectomía/métodos , Persona de Mediana Edad , Periodo Posoperatorio , Valor Predictivo de las Pruebas , Periodo Preoperatorio , Pronóstico , Estudios Retrospectivos , Resultado del Tratamiento , Escala Visual Analógica
11.
Medicine (Baltimore) ; 99(27): e21102, 2020 Jul 02.
Artículo en Inglés | MEDLINE | ID: mdl-32629743

RESUMEN

RATIONALE: Synovitis, acne, pustulosis, hyperostosis, and osteitis (SAPHO) syndrome is a rare disease without standard treatments. Tripterygium wilfordii hook f (TwHF) is a traditional Chinese herb with anti-inflammatory effect, and 1.0 mg/(kg·d) dose of Tripterygium glycosides has been reported to significantly improve the disease activity of a SAPHO patient in a case report. However, the optimal dose of TwHF is still unclear. Here, we report the first case of SAPHO patient who achieved rapid remission in clinical symptoms after receiving 1.5 mg/(kg·d) dose of Tripterygium glycosides treatment. PATIENT CONCERNS: A 67-year-old woman noted palmoplantar pustulosis and pain in the anterior chest wall and waist. Bone scintigraphy demonstrated the typical tracer accumulation feature and magnetic resonance images showed bone marrow edema in lumbosacral vertebra. DIAGNOSES: The diagnosis was made by dermatological and osteoarticular manifestations and classical signs in bone scintigraphy in accordance with the diagnostic criteria proposed in 2012. INTERVENTIONS: Tripterygium glycosides was given with a primary dose of 1.5 mg/(kg·d) for 1 month and then reduced at a rate of 10 mg every 2 weeks until 1.0 mg/(kg·d) for a long-term maintenance. OUTCOMES: Fast-induced remission on clinical manifestations was achieved and magnetic resonance imaging abnormality was improved significantly. Additionally, no apparent side effects were observed. LESSONS: 1.5 mg/(kg·d) dose of Tripterygium glycosides seems to have fast-induced remission than 1.0 mg/(kg·d) with reliable safety. Besides, Tripterygium glycosides may also have a pharmacological effect of inhibiting osteolysis and enhancing bone strength.


Asunto(s)
Síndrome de Hiperostosis Adquirido/tratamiento farmacológico , Huesos/patología , Medicamentos Herbarios Chinos/uso terapéutico , Glicósidos/uso terapéutico , Síndrome de Hiperostosis Adquirido/patología , Anciano , Huesos/diagnóstico por imagen , Huesos/efectos de los fármacos , Medicamentos Herbarios Chinos/administración & dosificación , Femenino , Glicósidos/administración & dosificación , Humanos , Región Lumbosacra/diagnóstico por imagen , Región Lumbosacra/patología , Imagen por Resonancia Magnética/métodos , Osteólisis/prevención & control , Psoriasis/etiología , Cintigrafía/métodos , Inducción de Remisión , Resultado del Tratamiento , Tripterygium
13.
Clin Nucl Med ; 45(9): 694-695, 2020 Sep.
Artículo en Inglés | MEDLINE | ID: mdl-32604123

RESUMEN

Fibrodysplasia ossificans progressiva is a rare debilitating, connective tissue disease characterized by progressive extraosseous ossification with abnormal great toes. Clinical (hallux valgus), radiological, and classical bone scan findings help to reach diagnosis and prevent patient from unnecessary surgical interventions for fibrodysplasia ossificans progressiva lesions and radiotherapy cycles. Here we present a case where a child presented with multiple swellings over the body and hallux valgus, and further bone scan findings helped to reach the diagnosis. The progressive nature of disease is difficult to halt, but early diagnosis can help in the delay of the disease process, by preventing trauma and giving disease-modifying agents.


Asunto(s)
Huesos/diagnóstico por imagen , Miositis Osificante/diagnóstico por imagen , Medronato de Tecnecio Tc 99m , Niño , Diagnóstico Precoz , Hallux/diagnóstico por imagen , Humanos , Masculino , Tomografía Computarizada por Rayos X
14.
Clin Nucl Med ; 45(10): e455-e456, 2020 Oct.
Artículo en Inglés | MEDLINE | ID: mdl-32604108

RESUMEN

In this case report, we present the bone scintigraphic findings of a 9-year-old boy with Gaucher disease who has a history of fractures to evaluate the extent of his osseous lesions. Gaucher disease is a genetic deficiency of lysosomal enzyme glucocerebrosidase, which results in the accumulation of glucocerebroside in the macrophages in the reticuloendothelial cells of the spleen, liver, and bone marrow. Most patients with type 1 Gaucher disease present a clinical or radiographic evidence of infiltrative bone disease. Lipid-filled macrophages called Gaucher cells infiltrate the bone marrow, leading to medullary expansion, diffuse osteoporosis, ischemic necrosis, and fractures.


Asunto(s)
Huesos/diagnóstico por imagen , Enfermedad de Gaucher/diagnóstico por imagen , Medronato de Tecnecio Tc 99m , Niño , Humanos , Masculino , Cintigrafía
15.
Dermatol Online J ; 26(5)2020 May 15.
Artículo en Inglés | MEDLINE | ID: mdl-32621708

RESUMEN

SAPHO syndrome is a rare entity, composed of dermatologic and osteoarticular manifestations. There are no validated diagnostic criteria and treatment is empirical, with a recent focus on biologics. Herein, we present a 50-year-old woman who developed palmoplantar pustulosis and sternoclavicular osteitis, with typical findings on bone scintigraphy. Treatment with bisphosphonate, low-dose systemic corticosteroid, and cyclosporine allowed complete resolution of the articular and dermatologic manifestations with no side effects.


Asunto(s)
Síndrome de Hiperostosis Adquirido/tratamiento farmacológico , Antiinflamatorios/uso terapéutico , Conservadores de la Densidad Ósea/uso terapéutico , Inmunosupresores/uso terapéutico , Huesos/diagnóstico por imagen , Ciclosporina/uso terapéutico , Quimioterapia Combinada , Femenino , Humanos , Ácido Ibandrónico/uso terapéutico , Persona de Mediana Edad , Prednisolona/uso terapéutico , Cintigrafía
16.
Clin Imaging ; 67: 15-29, 2020 Nov.
Artículo en Inglés | MEDLINE | ID: mdl-32502926

RESUMEN

Radiologists work in conjunction with orthopedic surgeons to evaluate the progression of bone healing and identify potential problems during bone reconstruction. Accurate evaluation and identification of healing progression or complications are critical to optimizing successful patient outcomes with either distraction osteogenesis or bone grafting. Therefore, radiologists must understand the fundamental concepts behind these surgical reconstructive techniques in order to provide accurate postoperative radiographic assessments. The cases and discussion within this review aim to provide this foundational knowledge.


Asunto(s)
Huesos/diagnóstico por imagen , Osteogénesis por Distracción/métodos , Procedimientos Quirúrgicos Reconstructivos/métodos , Trasplante Óseo , Femenino , Humanos , Radiólogos
17.
Clin Nucl Med ; 45(6): 492-494, 2020 Jun.
Artículo en Inglés | MEDLINE | ID: mdl-32366790

RESUMEN

A 39-year-old man with bone pain underwent Tc-MDP bone scan to assess skeletal lesions, which demonstrated multiple fractures and a focus of subtle extraosseous activity in the left thigh. A Tc-hynic-octreotide imaging was performed due to the suspected diagnosis of tumor-induced osteomalacia, which revealed a hypermetabolic subcutaneous nodule in the left thigh, which exactly corresponded to the same site of MDP activity. Biopsy confirmed the subcutaneous nodule as the culprit tumor of tumor-induced osteomalacia. Bone scan, as a conventional imaging, provided useful information for detecting culprit tumor as shown in our case.


Asunto(s)
Huesos/diagnóstico por imagen , Neoplasias de Tejido Conjuntivo/diagnóstico por imagen , Neoplasias de Tejido Conjuntivo/etiología , Medronato de Tecnecio Tc 99m , Adulto , Neoplasias Óseas/complicaciones , Humanos , Masculino , Cintigrafía , Tomografía Computarizada por Rayos X
18.
Adv Exp Med Biol ; 1194: 105-114, 2020.
Artículo en Inglés | MEDLINE | ID: mdl-32468527

RESUMEN

In this paper we present an approach toward human action detection for activities of daily living (ADLs) that uses a convolutional neural network (CNN). The network is trained on discrete Fourier transform (DFT) images that result from raw sensor readings, i.e., each human action is ultimately described by an image. More specifically, we work using 3D skeletal positions of human joints, which originate from processing of raw RGB sequences enhanced by depth information. The motion of each joint may be described by a combination of three 1D signals, representing its coefficients into a 3D Euclidean space. All such signals from a set of human joints are concatenated to form an image, which is then transformed by DFT and is used for training and evaluation of a CNN. We evaluate our approach using a publicly available challenging dataset of human actions that may involve one or more body parts simultaneously and for two sets of actions which resemble common ADLs.


Asunto(s)
Actividades Cotidianas , Huesos , Aprendizaje Profundo , Articulaciones , Rango del Movimiento Articular , Huesos/diagnóstico por imagen , Humanos , Articulaciones/diagnóstico por imagen , Redes Neurales de la Computación
19.
Clin Nucl Med ; 45(7): 549-551, 2020 Jul.
Artículo en Inglés | MEDLINE | ID: mdl-32433178

RESUMEN

A 24-year-old woman with left hip pain for 4 months was admitted. Radiographs of the left hip showed a radiolucent lesion in the proximal femur. The lesion demonstrated hypointensity on T1-weighted and high intensity on T2-weighted fat saturated images. Tc-MDP bone scan and F-FDG PET/CT illustrated intense radiotracer accumulation at the osteolytic lesion. Postoperative pathology confirmed a low-grade myofibroblastic sarcoma (LGMS). LGMS is a rare neoplasm, which often occurred in the head and neck region. Our case suggested that LGMS should be considered in the differential diagnosis of proximal femur lesion on Tc-MDP bone scan and F-FDG PET/CT.


Asunto(s)
Huesos/diagnóstico por imagen , Fluorodesoxiglucosa F18 , Miofibroblastos/patología , Tomografía Computarizada por Tomografía de Emisión de Positrones , Sarcoma/diagnóstico por imagen , Sarcoma/patología , Medronato de Tecnecio Tc 99m , Femenino , Humanos , Clasificación del Tumor , Adulto Joven
20.
BMC Med Genet ; 21(1): 115, 2020 05 27.
Artículo en Inglés | MEDLINE | ID: mdl-32460719

RESUMEN

BACKGROUND: Multiple epiphyseal dysplasia (MED) is a skeletal disorder characterized by delayed and irregular ossification of the epiphyses and early-onset osteoarthritis. At least 66% of the reported autosomal dominant MED (AD-MED) cases are caused by COMP mutations. METHODS: We recruited a four-generation Chinese family with early-onset hip osteoarthritis, flatfoot, brachydactyly, and mild short stature. An assessment of the family history, detailed physical examinations, and radiographic evaluations were performed on the proband and other family members, followed by the performance of whole-exome sequencing (WES). The pathogenicity of the candidate mutation was also analyzed. RESULTS: An AD-MED family with 10 affected members and 17 unaffected members was recruited. The main radiographic findings were symmetrical changes in the dysplastic acetabulum and femoral heads, irregular contours of the epiphyses, a shortened femoral neck, and flatfoot. Lower bone density was also observed in the ankle joints, wrist joints, and knees, as well as irregular vertebral end plates. In the proband, we identified the missense mutation c.1153G > T (p. Asp385Tyr), located in exon 11 of the COMP gene. This mutation was assessed as 'pathogenic' because of its low allele frequency and its high likelihood of co-segregation with disease in the reported family. Sanger sequencing validated the novel heterozygous mutation c.1153G > T (p. Asp385Tyr) in exon 11 of COMP in all affected individuals in the family. CONCLUSIONS: Our results underlined a key role of the Asp385 amino acid in the protein function of COMP and confirmed the pathogenicity of the COMP (c.1153G > T; p. Asp385Tyr) mutation in AD-MED disease. We have therefore expanded the known mutational spectrum of COMP and revealed new phenotypic information for AD-MED.


Asunto(s)
Proteína de la Matriz Oligomérica del Cartílago/genética , Familia , Estudios de Asociación Genética , Predisposición Genética a la Enfermedad , Mutación , Osteocondrodisplasias/diagnóstico , Osteocondrodisplasias/genética , Adolescente , Adulto , Anciano , Huesos/diagnóstico por imagen , Huesos/patología , Proteína de la Matriz Oligomérica del Cartílago/química , Niño , Femenino , Estudios de Asociación Genética/métodos , Humanos , Masculino , Persona de Mediana Edad , Modelos Moleculares , Linaje , Fenotipo , Conformación Proteica , Relación Estructura-Actividad , Secuenciación del Exoma Completo , Adulto Joven
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