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Recent Results Cancer Res ; 214: 1-70, 2020.
Artículo en Inglés | MEDLINE | ID: mdl-31473848


Exploiting the unique specificity of monoclonal antibodies has revolutionized the treatment and diagnosis of haematological and solid organ malignancies; bringing benefit to millions of patients over the past decades. Recent achievements include conjugating antibodies with toxic payloads resulting in superior efficacy and/or reduced toxicity, development of molecular imaging techniques targeting specific antigens for use as predictive and prognostic biomarkers, the development of novel bi- and tri-specific antibodies to enhance therapeutic benefit and abrogate resistance and the success of immunotherapy agents. In this chapter, we review an overview of antibody structure and function relevant to cancer therapy and provide an overview of pivotal clinical trials which have led to regulatory approval of monoclonal antibodies in cancer treatment. We further discuss resistance mechanisms and the unique side effects of each class of antibody and provide an overview of emerging therapeutic agents.

Anticuerpos Monoclonales/farmacología , Inmunoterapia , Neoplasias/terapia , Ensayos Clínicos como Asunto , Humanos
Recent Results Cancer Res ; 214: 71-91, 2020.
Artículo en Inglés | MEDLINE | ID: mdl-31473849


Bispecific T cell engagers are antibody constructs directed to a tumor-specific target on the one hand and to CD3-positive T cells on the other hand. Blinatumomab is a compound with specificity for the pan-B cell marker CD19. Clinical activity was tested in relapsed and refractory (R/R) non-Hodgkin's Lymphoma (NHL), R/R acute lymphoblastic leukemia (ALL), and ALL patients with minimal residual disease. Trials have already been started in de novo ALL. The most clinically relevant toxicities are neurologic events and cytokine release syndrome as with other T cell-activating therapies. The mechanisms of resistance are not fully understood. Higher leukemia load and later stage disease represent unfavorable factors. Besides, an upregulation of regulatory T cells and inhibitory molecules like PD-1/PD-L1 may have a role as the loss of target by several mechanisms. The future will show whether the use of bispecifics in ALL can change the standard treatment algorithms and whether bispecific T cell engagers will also be successfully used in other malignant entities.

Anticuerpos Biespecíficos/farmacología , Linfoma no Hodgkin/terapia , Leucemia-Linfoma Linfoblástico de Células Precursoras/terapia , Linfocitos T/citología , Antígenos CD19 , Ensayos Clínicos como Asunto , Humanos , Neoplasia Residual/terapia
Recent Results Cancer Res ; 214: 93-128, 2020.
Artículo en Inglés | MEDLINE | ID: mdl-31473850


As a specifically programmable, living immunotherapeutic drug, chimeric antigen receptor (CAR)-modified T cells are providing an alternative treatment option for a broad variety of diseases including so far refractory cancer. By recognizing a tumor-associated antigen, the CAR triggers an anti-tumor response of engineered patient's T cells achieving lasting remissions in the treatment of leukemia and lymphoma. During the last years, significant progress was made in optimizing the CAR design, in manufacturing CAR-engineered T cells, and in the clinical management of patients showing promise to establish adoptive CAR T cell therapy as an effective treatment option in the forefront.

Inmunoterapia Adoptiva , Neoplasias/terapia , Receptores Quiméricos de Antígenos , Antígenos de Neoplasias/inmunología , Ensayos Clínicos como Asunto , Humanos , Receptores de Antígenos de Linfocitos T , Linfocitos T/inmunología
Recent Results Cancer Res ; 214: 129-151, 2020.
Artículo en Inglés | MEDLINE | ID: mdl-31473851


The adoptive cell transfer (ACT) of genetically engineered T cell receptor (TCR) T cells is one of the burgeoning fields of immunotherapy, with promising results in current clinical trials. Presently, has over 200 active trials involving adoptive cell therapy. The ACT of genetically engineered T cells not only allows the ability to select for TCRs with desired properties such as high-affinity receptors and tumor reactivity but to further enhance those receptors allowing for better targeting and killing of cancer cells in patients. Moreover, the addition of genetic material, including cytokines and cytokine receptors, can increase the survival and persistence of the T cell allowing for complete and sustained remission of cancer targets. The potential for improvement in adoptive cell therapy is limitless, with genetic modifications targeting to improve weaknesses of ACT and to thus enhance receptor affinity and functional avidity of the genetically engineered T cells.

Ingeniería Genética , Inmunoterapia , Neoplasias/terapia , Receptores de Antígenos de Linfocitos T , Linfocitos T/citología , Humanos
Recent Results Cancer Res ; 214: 153-167, 2020.
Artículo en Inglés | MEDLINE | ID: mdl-31473852


After more than a century of efforts to establish cancer immunotherapy in clinical practice, the advent of checkpoint inhibition (CPI) therapy was a critical breakthrough toward this direction (Hodi et al. in Cell Rep 13(2):412-424, 2010; Wolchok et al. in N Engl J Med 369(2):122-133, 2013; Herbst et al. in Nature 515(7528):563-567, 2014; Tumeh et al. in Nature 515(7528):568-571, 2014). Further, CPIs shifted the focus from long studied shared tumor-associated antigens to mutated ones. As cancer is caused by mutations in somatic cells, the concept to utilize these correlates of 'foreignness' to enable recognition and lysis of the cancer cell by T cell immunity seems an obvious thing to do.

Vacunas contra el Cáncer , Epítopos/inmunología , Inmunoterapia , Neoplasias/terapia , Antígenos de Neoplasias/inmunología , Humanos
Recent Results Cancer Res ; 214: 169-187, 2020.
Artículo en Inglés | MEDLINE | ID: mdl-31473853


Treatment of patients with advanced metastatic melanoma has for decades been a story of very limited success. This dramatically changed when therapy with anti-PD-1 checkpoint blocking antibodies was approved in the USA and Europe in 2014 and 2015, respectively. The therapy exploits the capacity of CD8+ T cells to specifically kill tumor cells. Within the tumor microenvironment, CD8+ T cell activity is blocked by suppressive signals received via PD-1, an inhibitory co-receptor and so-called checkpoint of T cell activation. PD-1 binds to its ligand PD-L1 on melanoma cells which dampens the T cell's activity. Antibodies blocking inhibitory PD-1/PD-L1 interaction release T cells from suppression. Treatment of late-stage disease melanoma patients with antibodies targeting the PD-1/PD-L1 axis, termed immune checkpoint blocking therapy (ICBT), yields clinical frequently long-lasting responses in 30-40% of cases. Despite this remarkable breakthrough, still the majority of patients resists ICBT or develops resistance after initial therapy response. Administration of anti-PD-1 antibodies in combination with antibodies targeting CTLA-4, another inhibitory immune checkpoint increased clinical responses rate up to 50% but at costs of higher treatment-related toxicities. Thus, strong efforts are now directed toward the understanding of therapy resistance, the identification of biomarkers predicting therapy response, and the development of alternative PD-1-based combination treatment to improve patient outcomes.

Linfocitos T CD8-positivos/citología , Inmunoterapia , Melanoma/terapia , Receptor de Muerte Celular Programada 1 , Anticuerpos Monoclonales , Antígeno B7-H1 , Europa (Continente) , Humanos , Microambiente Tumoral
Rev Environ Contam Toxicol ; 251: 1-24, 2020.
Artículo en Inglés | MEDLINE | ID: mdl-31011831


Heavy metal pollution in surface water is a global environmental problem. This study analyzed the trends, health risks, and sources of eight dissolved heavy metal species in river and lake water across five continents (Africa, Asia, Europe, North America, and South America; Oceania was excluded owing to a lack of data) for the period 1970-2017. We wanted to assess the effects of various implemented countermeasures to pollution and to determine those that could be adopted worldwide. Collectively, the water system showed increasing trends for Cd, Cr, Cu, Ni, Mn, and Fe and decreasing trends for Pb and Zn. The mean dissolved concentrations of most heavy metals were highest in Asia and lowest in Europe. Most heavy metals had low non-carcinogenic risks over this period. The cancer risks associated with Pb were lower than the hazardous level on all five continents over the five decades, whereas the cancer risks related to Cr exceeded the hazardous level in the 1970s, 2000s, and 2010s, and in Africa, Asia, and North America over the entire period. Mining and manufacturing were consistently found to be critical sources of metal pollution from 1970 to 2017. However, the heavy metal sources differed significantly by continent, with waste discharge and rock weathering dominant in Africa; mining and manufacturing, along with rock weathering, are dominant in Asia and South America; fertilizer and pesticide use, along with rock weathering, are dominant in North America; and mining and manufacturing, waste discharge, and rock weathering are dominant in Europe. Global trends in the metal loadings in water and in relevant pollution-control measures suggest that countermeasures in Europe have successfully controlled heavy metal pollution. The successful measures include implementing rigorous standards for metal emissions, limiting the metal concentrations in products, and rigorously treating metal-contaminated waste. Therefore, the measures implemented in Europe should be extended worldwide to treat heavy metal pollution in water.

Exposición a Riesgos Ambientales/análisis , Metales Pesados/análisis , Contaminantes Químicos del Agua/análisis , Contaminación Química del Agua/estadística & datos numéricos , Exposición a Riesgos Ambientales/estadística & datos numéricos , Monitoreo del Ambiente , Humanos , Lagos , Ríos
Rev Environ Contam Toxicol ; 251: 131-184, 2020.
Artículo en Inglés | MEDLINE | ID: mdl-31129734


Maternal exposure to endocrine-disrupting chemicals (EDCs) is associated with long-term hormone-dependent effects that are sometimes not revealed until maturity, middle age, or adulthood. The aim of this study was to conduct descriptive reviews on animal experimental and human epidemiological evidence of the adverse health effects of in utero and lactational exposure to selected EDCs on the first generation and subsequent generation of the exposed offspring. PubMed, Web of Science, and Toxline databases were searched for relevant human and experimental animal studies on 29 October 29 2018. Search results were screened for relevance, and studies that met the inclusion criteria were evaluated and qualitative data extracted for analysis. The search yielded 73 relevant human and 113 animal studies. Results from studies show that in utero and lactational exposure to EDCs is associated with impairment of reproductive, immunologic, metabolic, neurobehavioral, and growth physiology of the exposed offspring up to the fourth generation without additional exposure. Little convergence is seen between animal experiments and human studies in terms of the reported adverse health effects which might be associated with methodologic challenges across the studies. Based on the available animal and human evidence, in utero and lactational exposure to EDCs is detrimental to the offspring. However, more human studies are necessary to clarify the toxicological and pathophysiological mechanisms underlying these effects.

Disruptores Endocrinos , Exposición Materna/estadística & datos numéricos , Animales , Femenino , Humanos , Embarazo
Rev Environ Contam Toxicol ; 249: 133-152, 2020.
Artículo en Inglés | MEDLINE | ID: mdl-30879139


Mercury (Hg) is an environmental contaminant that has been reported in many wildlife species worldwide. The organic form of Hg bioaccumulates in higher trophic levels, and thus, long-lived predators are at risk for higher Hg exposure. Although ecological risk assessments for contaminants such as Hg include pertinent receptor species, snakes are rarely considered, despite their high trophic status and potential to accumulate high levels of Hg. Our current knowledge of these reptiles suggests that snakes may be useful novel biomarkers to monitor contaminated environments. The few available studies show that snakes can bioaccumulate significant amounts of Hg. However, little is known about the role of snakes in Hg transport in the environment or the individual-level effects of Hg exposure in this group of reptiles. This is a major concern, as snakes often serve as important prey for a variety of taxa within ecosystems (including humans). In this review, we compiled and analyzed the results of over 30 studies to discuss the impact of Hg on snakes, specifically sources of exposure, bioaccumulation, health consequences, and specific scientific knowledge gaps regarding these moderate to high trophic predators.

Monitoreo del Ambiente , Mercurio/metabolismo , Serpientes/metabolismo , Contaminantes Químicos del Agua/metabolismo , Animales , Biomarcadores/metabolismo , Ecosistema , Humanos
J. sleep res ; : e12863, May 2019. ilus, tab
Artículo en Inglés | Sec. Est. Saúde SP, SESSP-IDPCPROD, Sec. Est. Saúde SP | ID: biblio-1007059


Overnight extracellular rostral fluid shifts have been shown to be of importance in patients with fluid-retaining states and are associated with a higher prevalence of sleep apnea. Pulmonary hypertension is frequently associated with right ventricular dysfunction and progressive right ventricular failure, and an increased prevalence of sleep apnea has been described. In light of the importance of fluid shifts in the pathophysiology of sleep apnea, we aimed to explore temporal fluid shifts in patients with pulmonary hypertension with and without sleep apnea. Patients with pulmonary hypertension (WHO Group 1 or 4) had overnight extracellular rostral fluid shift assessment before and a minimum of 3 months after initiation of pulmonary hypertension-specific therapy. Fluid shift measurements of extracellular leg, abdominal, thoracic and neck fluid volumes were performed simultaneously. Twenty-nine patients with pulmonary hypertension (age 55 ± 16 years, 69% female) participated. Sleep apnea was diagnosed in 15 subjects (apnea-hypopnea index 14 [8-27] per hr). There were no significant differences in baseline or overnight leg extracellular rostral fluid, abdominal extracellular rostral fluid, thoracic extracellular rostral fluid or neck extracellular rostral fluid between those with and without sleep apnea. There was a significant inverse correlation between the sleep apnea severity and the overnight change in leg extracellular rostral fluid (r = -0.375, p = 0.049). There were no significant differences detected in overnight extracellular rostral fluid shifts from baseline to follow-up. Treatment-naïve patients with pulmonary hypertension both with and without sleep apnea demonstrate overnight extracellular rostral fluid shifts from the legs into the thorax and neck. Pulmonary hypertension-specific treatment, while significantly improving cardiac haemodynamics, had little impact on nocturnal extracellular rostral fluid shifts or the presence of sleep apnea

Humanos , Disfunción Ventricular Izquierda , Apnea Obstructiva del Sueño , Líquido Extracelular
Estud. pesqui. psicol. (Impr.) ; 18(4): 1049-1067, out.-dez. 2019. ilus
Artículo en Portugués | LILACS, Index Psicología - Revistas técnico-científicas | ID: biblio-994958


Recorrentemente, o psicólogo-historiador se vê diante da questão, endereçada por seus pares ou alunos: por que estudar História da Psicologia? Tal questão é tão recorrente que livros-texto de História da Psicologia reservam um espaço para apresentar respostas, justificativas, a tal provocação. Diante disso, este artigo endereça uma resposta a tal questão, a partir da hipótese de que a História da Psicologia é uma ferramenta para compreensão de rupturas e permanências de fenômenos históricos vinculados aos campos Psi e, esta compreensão, nos auxilia em uma visão mais crítica do presente. Para atingir tal objetivo, são apresentados dois exemplos de questões históricas, mais ainda contemporâneas, na Psicologia brasileira: (a) a definição de campos de atuação e técnicas de atuação do psicólogo e (b) discursos e práticas normatizantes com pessoas homossexuais. Assim, a partir de tais exemplos que nos permitem ver a história na Psicologia e, também, a Psicologia na história, conclui-se que a História da Psicologia pode, sim, contribuir com uma análise mais crítica do momento presente. Para tanto, faz-se necessário a pesquisa em História da Psicologia e o ensino de sua história, para uma formação crítica do psicólogo brasileiro.(AU)

Frequently, the psychologist-historian of Psychology finds himself faced with the question, addressed by his peers or students: why should we study the History of Psychology? Textbooks on the History of Psychology reserve some sections to present such justifications to their readers, indeed. Therefore, we aim to give an answer to that question, based on the hypothesis that the History of Psychology is a tool for understanding ruptures and permanencies of Psychological phenomena in the history, and this understanding helps us to build up a more critical view of the present. In order to achieve that goal, two examples of historical issues in Brazilian Psychology ­ that are still contemporary - are presented: (a) the definition of fields of application and their techniques, and (b) normative discourses and practices with homosexual people. Thus, from such examples that allow us to see history in Psychology and also Psychology in history, we conclude that the History of Psychology would contribute for a more critical analysis of the present. Therefore, it is necessary to research in History of Psychology and to teach its history, for a critical formation of the Brazilian psychologist.(AU)

Frecuentemente, el psicólogo-historiador se ve ante la cuestión, direccionada por sus pares o alumnos: ¿por qué estudiar Historia de la Psicología? Tal cuestión es tan recurrente que libros didácticos de Historia de la Psicología reservan un espacio para presentar respuestas, justificaciones, a tal provocación. Por lo tanto, este artículo brinda una respuesta a tal cuestión, a partir de la hipótesis de que la Historia de la Psicología constituye una herramienta para la comprensión de rupturas y permanencias de fenómenos históricos vinculados a los saberes Psi y que esta comprensión nos auxilia en una visión más crítica del presente. Para alcanzar tal objetivo, se presentan dos ejemplos de cuestiones históricas, más aún contemporáneas, en la Psicología brasileña: (a) la definición de campos de actuación y técnicas de actuación del psicólogo y (b) discursos y prácticas de normativización con personas homosexuales. Así, a partir de tales ejemplos que nos permiten ver la historia en la Psicología y, también, la Psicología en la historia, se concluye que la Historia de la Psicología sí puede contribuir a un análisis más crítico del momento presente. Para ello, se hace necesaria la investigación en Historia de la Psicología y la enseñanza de su historia, para una formación crítica del psicólogo brasileño.(AU)

Humanos , Psicología/historia , Psicología/métodos , Enseñanza/psicología , Psicología
Estud. pesqui. psicol. (Impr.) ; 18(4): 1118-1136, out.-dez. 2019. tab
Artículo en Portugués | LILACS, Index Psicología - Revistas técnico-científicas | ID: biblio-994978


O presente artigo objetivou realizar uma análise sobre como a temática da pobreza tem historicamente comparecido nos estudos e parâmetros de atuação profissional do psicólogo brasileiro. Foi realizada uma revisão bibliográfica acerca do objeto de estudo, o resgate de produções pertinentes sobre a relação da Psicologia brasileira com a pobreza ao longo de seu desenvolvimento, bem como de documentos e parametrizações do Conselho Federal de Psicologia. Observamos um crescimento do envolvimento da Psicologia com a pobreza e demais expressões da "questão social", atrelado com a maior vinculação da profissão com as políticas públicas e sociais. O debate entre "questão social", pobreza e Psicologia, contextualizado em diferentes fases do capitalismo, face às particularidades brasileiras e atual conjuntura, evidencia as contradições: autocrítica acerca do distanciamento com a realidade brasileira e insuficiências teórico-práticas, mas com a hegemonia na Psicologia ainda se fazendo valer por meio de leituras e práticas individualizantes, psicologizantes, perpetradoras da ordem. Dessa forma, uma Psicologia compromissada com a compreensão e superação da pobreza, assim como do sistema que a forja e nela se sustenta, requer a identificação e libertação de sua própria pobreza.(AU)

The present article aims to analyze how the issue of poverty has historically appeared in studies and parameters of the professional work of Brazilian psychologists. A bibliographic review about the object of the study was elaborated, with the retrieval of relevant works about the relationship between Brazilian Psychology and poverty throughout its development, as well as documents and parametrizations of the Federal Council of Psychology. We see an increase in the involvement of Psychology with poverty and other expressions of the "social issue", linked to the greater bondage of the profession with public and social policies. The debate between "social issue", poverty and Psychology, contextualized in different phases of capitalism, in view of the Brazilian characteristics and current situation, shows the following contradictions: self-criticism about distancing from Brazilian reality and theoretical-practical insufficiencies, but with the hegemony in Psychology still being enforced through individualizing, psychologizing readings and practices, perpetrating the order. In this way, a Psychology committed to understanding and overcoming poverty, as well as the system that forges and sustains it, requires the identification and liberation of its own poverty.(AU)

El presente artículo apuntó a realizar un análisis sobre cómo la temática de la pobreza ha formado parte históricamente en los estudios y parámetros de actuación profesional del psicólogo brasileño. Se realizó una revisión bibliográfica acerca del objeto de estudio y un rescate de producciones pertinentes sobre la relación de la Psicología brasileña con la pobreza a lo largo de su desarrollo, así como de documentos del Consejo Federal de Psicología. Observamos un crecimiento de la implicación de la Psicología con la pobreza y demás expresiones de la cuestión social, vinculada con la mayor ligazón de la profesión con las políticas públicas y sociales. El debate entre "cuestión social", pobreza y Psicología, contextualizado en diferentes fases del capitalismo, frente a las particularidades brasileñas y la coyuntura actual, evidencia las siguientes contradicciones: autocrítica acerca del distanciamiento con la realidad brasileña y las insuficiencias teórico-prácticas, empero existe una hegemonía en la Psicología que todavía se hace valer por medio de lecturas y prácticas individualizantes, psicologizantes, perpetradoras del orden. Así, una Psicología comprometida con la comprensión y superación de la pobreza y con el sistema que la forja y en ella se sustenta, requiere de la identificación y liberación de su propia pobreza.(AU)

Humanos , Pobreza/psicología , Sociología/historia , Capitalismo , Psicología , Política Pública , Brasil , Historia
Estud. pesqui. psicol. (Impr.) ; 18(4): 1137-1154, out.-dez. 2019.
Artículo en Portugués | LILACS, Index Psicología - Revistas técnico-científicas | ID: biblio-994979


Apresenta-se um panorama da Neuropsicologia brasileira, enfocando sua inserção no país, caracterizando o momento atual e desafios à sua consolidação. Aborda-se a trajetória da Neuropsicologia, traçando-se cinco períodos que a caracterizam, bem como sua trajetória nacional. A Neuropsicologia brasileira assiste à sofisticação da neuroimagem e ao avanço da pesquisa e interesse na área, à criação de entidades representativas, ao crescente número de publicações, grupos de pesquisa e de cursos de pós-graduação, ao desenvolvimento de instrumentos brasileiros e à ampliação da normatização e validação de instrumentos estrangeiros. Apesar desses avanços, ressalta-se a necessidade de constituir uma Neuropsicologia brasileira, sintonizada com os desafios de um país diverso, que contribua com políticas públicas, produza conhecimentos que atinjam diferentes populações e contribua para a diminuição das desigualdades sociais.(AU)

This paper aims to present an overview of Brazilian neuropsychology, focusing on the way the discipline was brought to Brazil, the present panorama of the discipline, and the challenges related to its consolidation. This article addresses the historical course of Neuropsychology, mapping the five distinct periods that characterized its history, as well as its national course. Brazilian neuropsychology is currently aided by the sophistication of neuroimaging techniques, the advancement in research and the interest in the area, as well as the creation of representative professional associations, the growing number of publications, research groups and graduate courses, the development of Brazilian instruments and the increase in standardization and validation of foreign instruments. Despite these advances, it is necessary to emphasize the need to make a Brazilian Neuropsychology, in tune with the challenges that come from a diverse country, one which contributes with public policies, produces knowledge that reaches different peoples and contributes towards reducing social inequalities.(AU)

Este artículo presenta un panorama de la Neuropsicología en Brasil, enfocándose en su inserción en el país, caracterizando el momento actual y los desafíos a su consolidación. Aborda la historia de la Neuropsicología, trazando los cinco períodos que la caracterizan y su trayectoria nacional. La Neuropsicología brasileña presencia la sofisticación de las técnicas de neuroimagen y el avance de la investigación y el interés de los estudiantes y profesionales, así como la creación de órganos representativos, el creciente número de grupos de investigación, cursos postgrado y publicaciones, el desarrollo de instrumentos brasileños de evaluación neuropsicológica y la estandarización de los procesos y validación de instrumentos extranjeros. A pesar de esos avances, se destaca la necesidad de establecer una Neuropsicología brasileña, en sintonía con desafíos y urgencias de un país diverso, que contribuya con políticas públicas, produzca y ponga en práctica conocimientos que alcancen diferentes poblaciones y contribuya con la reducción de las desigualdades sociales.(AU)

Humanos , Psicología Aplicada , Neuropsicología , Investigación , Brasil , Neuroimagen/psicología , Historia
Estud. pesqui. psicol. (Impr.) ; 18(4): 1155-1174, out.-dez. 2019.
Artículo en Portugués | LILACS, Index Psicología - Revistas técnico-científicas | ID: biblio-994981


O presente artigo tem por objetivo traçar uma genealogia possível da técnica psicanalítica apontando para a importância das dimensões histórica, política e social na construção da psicanálise. A partir do fenômeno do magnetismo animal, postulado por Franz Anton Mesmer, no século XVIII, passando pela hipnose e pela sugestão até alcançarmos a transferência na psicanálise, buscaremos remontar a influência como pressuposto ético-político que perpassa e, mesmo, possibilita todas essas práticas.(AU)

The present article aims to delineate a possible genealogy of the psychoanalytical technique indicating the importance of the historical, political and social dimensions in the construction of the psychoanalysis. From the animal magnetism phenomenon, postulated by Franz Anton Mesmer, in the eighteenth century, moving to hypnosis and suggestion until achieving the transference in psychoanalysis, we seek reassemble the influence as ethical-politic presuppose that passes through, and yet, makes possible all these practices.(AU)

El artículo tiene por objectivo trazar una genealogía possible de la técnica psicoanalítica marcando la importancia de las dimenciones históricas, política y sociales en la construcción de la psicoanálisis. A partir del fenômeno del magnetismo animal, propuesto por Franz Anton Mesmer, en siglo XVIII, pasando por la hipnosis y por la sugestión, hasta encuentrarmos la transferencia psicoanalítica, intentamos remontar la influencia como pressupuesto ético-político que atraviesa y possibilita todas esas practicas.(AU)

Humanos , Psicoanálisis , Política , Hipnosis , Libido
Estud. pesqui. psicol. (Impr.) ; 18(4): 1175-1194, out.-dez. 2019.
Artículo en Portugués | LILACS, Index Psicología - Revistas técnico-científicas | ID: biblio-994982


Este artigo se propõe a analisar a situação da psicanálise nos cursos de psicologia das universidades do Rio de Janeiro, estabelecendo uma comparação com o caso de Buenos Aires. Para tal fim, utiliza um método de análise que implica construção documental, entrevistas e estudo teórico sobre a história e a atualidade da psicologia e da psicanálise nessas cidades. Entende-se que, além da chamada "crise" da psicanálise, ela mantém uma posição predominante nesses cursos. Espera-se que este trabalho contribua para uma discussão contextualizada dos cursos de psicologia em suas revisões curriculares.(AU)

We aim to analyse the situation of psychoanalysis in psychology undergraduate courses from universities of Rio de Janeiro, comparing these with the ones from Buenos Aires. For that purpose, we use a method of analysis that involves documental construction, interviews and theoretical study on the past history and the present reality of psychology and psychoanalysis in those cities. We understand that, besides the so-called "crisis" of psychoanalysis, this theoretical orientation maintains a predominant position in those courses. We expect that this work contributes to a contextualized discussion of psychology undergraduate courses and their curricular revisions.(AU)

Se propone analizar la situación del psicoanálisis en las carreras de psicología de universidades de Rio de Janeiro, estableciendo una comparación con el caso de Buenos Aires. Para tal fin, se utiliza un método de análisis que implica construcción documental, entrevista y estudio teórico, sobre la historia y actualidad de la psicología y el psicoanálisis en esas ciudades. Se entiende que, más allá de la llamada "crisis" del psicoanálisis, éste mantiene una posición predominante en esos cursos. Se espera que este trabajo contribuya a una discusión contextualizada de las carreras de Psicología y sus revisiones curriculares.(AU)

Humanos , Psicoanálisis , Psicología , Argentina , Universidades , Brasil
Estud. pesqui. psicol. (Impr.) ; 18(4): 1195-1214, out.-dez. 2019.
Artículo en Portugués | LILACS, Index Psicología - Revistas técnico-científicas | ID: biblio-994984


O período de 1870 a 1920 é conhecido como aquele no qual diversos teóricos da psicologia estadunidense estabelecem as diretrizes teóricas e políticas da independência da disciplina frente às demais ciências e às reflexões filosóficas. A psicologia comparada proposta por Robert Mearns Yerkes é uma das mais importantes do final do século XIX e das duas primeiras décadas do século seguinte. As obras do autor referentes à evolução do sistema nervoso central e periférico e suas relações com a inteligência, em conjunto com a psicologia militar e a eugenia, possibilitam, ao menos em parte, a concretização da engenharia humana e de suas futuras aplicações em diversos setores da sociedade estadunidense como instrumento de dominação da classe dominante. Como se trata de uma obra vasta e variadas aplicações na vida cotidiana, pensamos que essa primeira aproximação seja aprofundada em futuras investigações acerca dos movimentos da classe trabalhadora durante o processo de modernização da indústria e da grande reforma social pela qual a sociedade estadunidense à época. Movimentos amplamente desprezados pela historiografia da psicologia estadunidense.(AU)

The period from 1870 to 1920 is known as the one in which several theorists of American psychology establish the theoretical and political guidelines of the discipline's independence from other sciences and philosophical domain. The comparative psychology proposed by Robert Mearns Yerkes is one of the most important of the late nineteenth century and the first two decades of the following century. The author's works on the evolution of the central and peripheral nervous system and its relations with intelligence, taken together with military psychology and eugenics, enable, at least in part, the concretization of human engineering and its future applications in various sectors of the American society as an instrument of domination of the ruling class. As it is a vast work and of varied applications in everyday life, we think that this first approximation will be deepened in future investigations about the movements of the working class during the process of modernization of the industry and of the great social reform by which the American society happened to the time. These movements were widely neglected by the historiography of American psychology.(AU)

El período de 1870 a 1920 es conocido como aquel en el cual diversos teóricos de la psicología estadounidense establecen las directrices teóricas y políticas de la independencia de la disciplina frente a las demás ciencias y reflexiones filosóficas. La psicología comparada propuesta por Robert Mearns Yerkes es una de las más importantes del fin del siglo XIX y de las dos primeras décadas del siglo siguiente. Las obras del autor referentes a la evolución del sistema nervioso central y periférico y sus relaciones con la inteligencia, en conjunto con la psicología militar y la eugenesia, posibilitan, al menos en parte, la concreción de la ingeniería humana y de sus futuras aplicaciones en diversos sectores de la sociedad estadounidense como instrumento de dominación de la clase dominante. Como se trata de una obra vasta y de variadas aplicaciones en la vida cotidiana, esperamos que esa primera aproximación sea profundizada en futuras investigaciones acerca de los movimientos de la clase trabajadora durante el proceso de modernización de la industria y de la gran reforma social por la que la sociedad estadounidense pasaba en esa época. Estos movimientos fueron ampliamente despreciados por la historiografía de la psicología estadounidense.(AU)

Humanos , Masculino , Psicología/historia , Ergonomía , Psicología Comparada , Psicología Militar , Eugenia , Sistema Nervioso
Estud. pesqui. psicol. (Impr.) ; 18(4): 1215-1238, out.-dez. 2019. tab
Artículo en Inglés | LILACS, Index Psicología - Revistas técnico-científicas | ID: biblio-994985


The article reviews the process of conformation of the International Center for Genetic Epistemology (CIEG), which functioned at the University of Geneva between 1955 and 1986. This Center led by Jean Piaget had the collaboration of hundreds of researchers from around the world and from different disciplines. We will here review the configuration of the centripetal circuits that led to the constitution of an institution with a double centrality. On the one hand, taking into account the history of international scientific circulations, it is feasible to recognize in the CIEG a reference point from which the radial journeys of social exchanges with different scientific communities can be reconstructed. On the other hand, we can identify a research program that positioned psychology at the core of epistemological debates. To contribute to the historical analysis of this double movement of centration, geography and theory, we examine the development of a series of strategies tending to the start-up of the Center, deployed during the first years of the 1950s.(AU)

O artigo analisa o processo de constituição do Centro Internacional de Epistemologia Genética (CIEG), localizado na Universidade de Genebra entre 1955 e 1986. Este centro liderado por Jean Piaget contava com a colaboração de centenas de pesquisadores de todo o mundo e de diferentes disciplinas. Aqui, revisaremos a configuração dos circuitos centrípetos que levaram à constituição de uma instituição com dupla centralidade. Por um lado, levando em conta a história das circulações científicas internacionais, é viável reconhecer no CIEG um ponto de referência a partir do qual as viagens radiais de trocas sociais com diferentes comunidades científicas podem ser reconstruídas. Por outro lado, podemos identificar um programa de pesquisa que posicionou a psicologia no centro dos debates epistemológicos. Para contribuir com a análise histórica desse duplo movimento de centralização, geografia e teoria, examinamos o desenvolvimento de uma série de estratégias, do Centro, implantadas nos primeiros anos da década de 1950.(AU)

El artículo revisa el proceso de conformación del Centro Internacional de Epistemología Genética (CIEG), radicado en la Universidad de Ginebra entre 1955 y 1986. Este Centro liderado por Jean Piaget contó con la colaboración de cientos de investigadores de todo el mundo y de diversas disciplinas. Aquí, nos ocuparemos de revisar la configuración de los circuitos centrípetos que desembocaron en la constitución de una institución con una doble centralidad. Por un lado, atendiendo a la historia de las circulaciones científicas internacionales, es factible reconocer en el CIEG un lugar de referencia desde el cual pueden reconstruirse los trayectos radiales de intercambios sociales con diferentes comunidades científicas. Por otra parte, podemos identificar un programa de investigación que posicionó a la psicología en el núcleo de los debates epistemológicos. Para contribuir al análisis histórico de este doble movimiento de centralización, geográfica y teórica, examinamos el desarrollo de una serie de estrategias tendientes a la puesta en marcha del Centro, desplegadas durante los primeros años de la década de 1950.(AU)

Humanos , Psicología , Conocimiento , Historia
MMWR Morb Mortal Wkly Rep ; 68(35): 766-770, 2019 Sep 06.
Artículo en Inglés | MEDLINE | ID: mdl-31487277


Hepatitis A virus (HAV) is an RNA virus primarily transmitted via the fecal-oral route and, in rare cases, causes liver failure and death in infected persons. Although drinking water-associated hepatitis A outbreaks in the United States are rarely reported (1), HAV was the most commonly reported etiology for outbreaks associated with untreated ground water during 1971-2008 (2), and HAV can remain infectious in water for months (3). This report analyzes drinking water-associated hepatitis A outbreaks reported to the Waterborne Disease and Outbreak Surveillance System (WBDOSS) during 1971-2017. During that period, 32 outbreaks resulting in 857 cases were reported, all before 2010. Untreated ground water was associated with 23 (72%) outbreaks, resulting in 585 (68.3%) reported cases. Reported outbreaks significantly decreased after introduction of Advisory Committee on Immunization Practices (ACIP) hepatitis A vaccination recommendations* and U.S. Environmental Protection Agency's (USEPA) public ground water system regulations.† Individual water systems, which are not required to meet national drinking water standards,§ were the only contaminated drinking water systems to cause the last four reported hepatitis A outbreaks during 1995-2009. No waterborne outbreaks were reported during 2009-2017. Water testing and treatment are important considerations to protect persons who use these unregulated systems from HAV infection.

Brotes de Enfermedades/prevención & control , Agua Potable/virología , Hepatitis A/epidemiología , Hepatitis A/prevención & control , Práctica de Salud Pública , Regulación Gubernamental , Vacunas contra la Hepatitis A/administración & dosificación , Humanos , Evaluación de Programas y Proyectos de Salud , Estados Unidos/epidemiología , United States Environmental Protection Agency , Abastecimiento de Agua/legislación & jurisprudencia