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1.
Chemosphere ; 249: 126099, 2020 Jun.
Artículo en Inglés | MEDLINE | ID: mdl-32059149

RESUMEN

Indium and gallium are used widely in modern industry, mostly for the production of semiconductors. They are considered as Technology-Critical Elements and have therefore received growing attention in the past few years. We investigated the influence of different types of humic substances on the transport of indium and gallium in laboratory-scale, saturated column experiments, to gain understanding of their mobility in natural environments. We evaluated the effect of different humic substances on the transport of indium and gallium in quartz sand: a commercial humic acid (Aldrich Humic Acid, AHA), a fulvic acid (Suwannee River Fulvic Acid, SRFA) and an aquatic natural organic matter (Suwannee River Natural Organic Matter, SRNOM). The impact of the flow rate and the influence of different concentrations of organic matter were also investigated. Indium was shown to be more mobile than gallium in the presence of humic substances. The mobility of indium in sand was highest for SRNOM, followed by SRFA and then AHA, while for gallium the order was SRFA > SRNOM > AHA. These results can be significant in understanding the mobility of indium and gallium in soils with various compositions of organic matter.


Asunto(s)
Galio/química , Sustancias Húmicas/análisis , Indio/química , Benzopiranos , Modelos Químicos , Porosidad , Ríos , Suelo
2.
Nat Commun ; 11(1): 1002, 2020 02 21.
Artículo en Inglés | MEDLINE | ID: mdl-32081910

RESUMEN

Innovations in soft material synthesis and fabrication technologies have led to the development of integrated soft electronic devices. Such soft devices offer opportunities to interact with biological cells, mimicking their soft environment. However, existing fabrication technologies cannot create the submicron-scale, soft transducers needed for healthcare and medical applications involving single cells. This work presents a nanofabrication strategy to create submicron-scale, all-soft electronic devices based on eutectic gallium-indium alloy (EGaIn) using a hybrid method utilizing electron-beam lithography and soft lithography. The hybrid lithography process is applied to a biphasic structure, comprising a metallic adhesion layer coated with EGaIn, to create soft nano/microstructures embedded in elastomeric materials. Submicron-scale EGaIn thin-film patterning with feature sizes as small as 180 nm and 1 µm line spacing was achieved, resulting in the highest resolution EGaIn patterning technique to date. The resulting soft and stretchable EGaIn patterns offer a currently unrivaled combination of resolution, electrical conductivity, and electronic/wiring density.


Asunto(s)
Equipos y Suministros Eléctricos , Electrónica/instrumentación , Metales , Nanotecnología/métodos , Aleaciones , Elastómeros , Conductividad Eléctrica , Diseño de Equipo , Galio , Indio , Industria Manufacturera/métodos , Impresión , Propiedades de Superficie
3.
Anal Bioanal Chem ; 412(8): 1893-1899, 2020 Mar.
Artículo en Inglés | MEDLINE | ID: mdl-32016568

RESUMEN

Superoxide dismutase (SOD), also known as liver protein, is a substance widely distributed in various biological cells. It has the function of catalyzing the disproportionation reaction of superoxide free radicals. SOD can form an antioxidant chain together with peroxidase, catalase, and other substances in the body of organisms, and thus, is one of the indispensable important substances in the body of organisms. In this work, we provided a simple and fast visual electrochemiluminescence (ECL) sensor for SOD detection. CuInZnS quantum dots (QDs) worked as the ECL luminophore with hydrogen peroxide as co-reactant. In the sensing process, SOD and CuInZnS QDs on a glassy carbon electrode (GCE) competed with each other for hydrogen peroxide to produce superoxide during electrochemical luminescence, thus quenching the ECL signal of CuInZnS QDs. The proposed sensor can quantify SOD with a limit of detection (LOD) of 0.03 µg/mL. In addition, the change in the CuInZnS QDs ECL signal was easily observed with a smartphone camera. The results indicated that this sensor could effectively work in the detection of SOD in human blood. Graphical abstract.


Asunto(s)
Cobre/química , Técnicas Electroquímicas/métodos , Indio/química , Luminiscencia , Puntos Cuánticos/química , Sulfuros/química , Superóxido Dismutasa/análisis , Compuestos de Zinc/química , Técnicas Biosensibles , Límite de Detección , Reproducibilidad de los Resultados
4.
Environ Monit Assess ; 192(2): 133, 2020 Jan 22.
Artículo en Inglés | MEDLINE | ID: mdl-31970566

RESUMEN

In this study, a new liquid-phase microextraction method termed sieve-conducted two-syringe-based pressurized liquid-phase microextraction (SCTS-PLPME) was developed as a preconcentration tool for indium. Here, two syringes were connected to each other by an apparatus to produce an environment subject to pressure. The pressure created between the two syringes by simultaneous movements of the syringe plungers (to and fro) generated an efficient dispersion and this eliminated the need for dispersive solvents. Determination of indium after preconcentration was carried out with a slotted quartz tube attached flame atomic absorption spectrometer (SQT-FAAS). The detection limit (LOD) and quantification limit (LOQ) of the developed method were calculated as 19.2 and 72.2 µg L-1, respectively. The reliability and accuracy of the developed method was tested by performing recovery studies on lake water spiked at different concentrations and the obtained percent recoveries were between 101.2 and 106.9%.


Asunto(s)
Microextracción en Fase Líquida , Contaminantes Químicos del Agua , Monitoreo del Ambiente , Indio/análisis , Límite de Detección , Microextracción en Fase Líquida/métodos , Cuarzo , Reproducibilidad de los Resultados , Espectrofotometría Atómica , Jeringas , Contaminantes Químicos del Agua/análisis
5.
Waste Manag ; 102: 635-644, 2020 Feb 01.
Artículo en Inglés | MEDLINE | ID: mdl-31785523

RESUMEN

Indium is one of the components with great recycling value in waste LCDs. Degradation of organic materials and the remain of indium in the solid phase can be simultaneously achieved by hydrothermal pretreatment via parameter regulation. Indium was transferred from the solid phase to the liquid phase by using sulfuric acid after hydrothermal pretreatment. Di-(2-ethylhexyl) phosphoric acid diluted by sulfonated kerosene and hydrochloric acid were used as extractant and stripping agent respectively to purify and concentrate indium from acidic leaching solution. The results indicated that the leaching yield of indium reached 100% under the optimal condition of reaction time of 40 min, reaction temperature of 70-80 °C, acid concentration of 0.5 M and solid-liquid (S/L) ratio of 1:2 g/mL. Given conditions of extraction time of 3 min at the organic phase to aqueous phase (O/A) ratio of 1:10 by 20% D2EHPA and stripping time of 10 min at the (O/A) ratio of 10:1 by 4 M HCl, the recovery efficiency of indium reached 97.25%. In addition, acid leaching process did not change the surface topography and molecular structure of glass substrate and had no negative effect on subsequent recycling of glass. The kinetic equation of leaching yield and reaction time at the temperature of 80 °C is 1 - (1 - y)1/3 = 0.0215 t. The reaction activation energy of metal indium leaching process is 50.64 kJ/mol.


Asunto(s)
Residuos Electrónicos , Cristales Líquidos , Indio , Queroseno , Cinética , Reciclaje
6.
Chem Commun (Camb) ; 56(2): 301-304, 2019 Dec 19.
Artículo en Inglés | MEDLINE | ID: mdl-31808472

RESUMEN

Bioimaging has revolutionized modern medicine, and nanotechnology can offer further specific and sensitive imaging. We report here an amphiphilic dendrimer able to self-assemble into supramolecular nanomicelles for effective tumor detection using SPECT radioimaging. This highlights the promising potential of supramolecular dendrimer platforms for biomedical imaging.


Asunto(s)
Dendrímeros/química , Nanoestructuras/química , Tensoactivos/química , Adenocarcinoma/diagnóstico por imagen , Animales , Línea Celular Tumoral , Quelantes/síntesis química , Quelantes/química , Dendrímeros/síntesis química , Compuestos Heterocíclicos con 1 Anillo/síntesis química , Compuestos Heterocíclicos con 1 Anillo/química , Humanos , Indio , Radioisótopos de Indio , Ratones , Micelas , Neoplasias Pancreáticas/diagnóstico por imagen , Radioisótopos , Tensoactivos/síntesis química , Tomografía Computarizada de Emisión de Fotón Único/métodos
7.
Harefuah ; 158(12): 789-794, 2019 Dec.
Artículo en Hebreo | MEDLINE | ID: mdl-31823532

RESUMEN

INTRODUCTION: Nuclear medicine techniques are suggested to be used in equivocal cases only. Nuclear medicine procedures, specifically labeled leucocytes however, are widely used in the diagnosis of joint infection across Europe. The aim of our study was to determine if Indium 111 labeled leukocyte scintigraphy has a role in the diagnosis of infected prosthetic joints. METHODS: In this retrospective cohort study, the records of a total of 146 prosthetic hip or knee revision surgeries, in 116 patients, performed in our Institute between the years 2013-2016 were reviewed. A total of 34 patients with labeled leukocyte scans were analyzed. Ten patients had more than one scan (two to four times). The scintigraphy result reports were correlated with the outcome with respect to intra-/post-operative diagnosis of prosthetic joint infection. RESULTS: The findings of 42 of 44 scintigraphy tests were negative. One study in a patient who had three prior negative labeled white blood cells (WBC) scintigraphies was equivocal. One study was positive, but a later test in the same patient was negative. Of these 34 patients, nine were demonstrated intra- or post operatively as positive for infected prosthetic joint, including the two positive cases above. The remaining 25 patients went through revision surgery with no evidence of infection; 30 of 38 bone scans were positive. Of these 30 patients, seven were demonstrated intra- or post-operatively as positive for infected prosthetic joint. CONCLUSIONS: In our study population indium labeled leukocyte scintigraphy was found to be a non-sensitive test for the diagnosis of a prosthetic joint infection and had a poor negative predictive value. It is expected that following the guidelines more strictly and choosing the appropriate modality for assessing prosthetic joint infection will improve the diagnostic accuracy of these techniques.


Asunto(s)
Indio , Infecciones Relacionadas con Prótesis/diagnóstico , Cintigrafía , Europa (Continente) , Humanos , Leucocitos , Estudios Retrospectivos , Sensibilidad y Especificidad
8.
Int J Nanomedicine ; 14: 9577-9586, 2019.
Artículo en Inglés | MEDLINE | ID: mdl-31824152

RESUMEN

Purpose: Quantum dots (QDs) are widely used semiconductor nanomaterials. Indium phosphide/zinc sulfide (InP/ZnS) QDs are becoming potential alternatives to toxic heavy metal-containing QDs. However, the potential toxicity and, in particular, the immunotoxicity of InP/ZnS QDs are unknown. This study aimed to investigate the impacts of InP/ZnS QDs on inflammatory responses both in vivo and in vitro. Methods: Mice and mouse bone marrow-derived macrophages (BMMs) were exposed to polyethylene glycol (PEG) coated InP/ZnS QDs. The infiltration of neutrophils and the release of interleukin-6 (IL-6) were measured using a hematology analyzer and an enzyme-linked immunosorbent assay (ELISA) for the in vivo test. Cytotoxicity, IL-6 secretion, oxidative stress and endoplasmic reticulum (ER) stress were studied in the BMMs, and then, inhibitors of oxidative stress and ER stress were used to explore the mechanism of the InP/ZnS QDs. Results: We found that 20 mg/kg PEG-InP/ZnS QDs increased the number of neutrophils and the levels of IL-6 in both peritoneal lavage fluids and blood, which indicated acute phase inflammation in the mice. PEG-InP/ZnS QDs also activated the BMMs and increased the production of IL-6. In addition, PEG-InP/ZnS QDs triggered oxidative stress and the ER stress-related PERK-ATF4 pathway in the BMMs. Moreover, the inflammatory response caused by the PEG-InP/ZnS QDs could be attenuated in the macrophages by blocking the oxidative stress or the ER stress with inhibitors. Conclusion: InP/ZnS QDs can activate macrophages and induce acute phase inflammation both in vivo and in vitro, which may be regulated by oxidative stress and ER stress. Our present work is expected to help clarify the biosafety of InP/ZnS QDs and promote their safe application in biomedical and engineering fields.


Asunto(s)
Estrés del Retículo Endoplásmico/efectos de los fármacos , Indio/farmacología , Macrófagos/patología , Estrés Oxidativo/efectos de los fármacos , Fosfinas/farmacología , Puntos Cuánticos/química , Sulfuros/farmacología , Compuestos de Zinc/farmacología , Animales , Femenino , Depuradores de Radicales Libres/farmacología , Regulación de la Expresión Génica/efectos de los fármacos , Inflamación/genética , Inflamación/patología , Interleucina-6/metabolismo , Macrófagos/efectos de los fármacos , Macrófagos/metabolismo , Ratones Endogámicos C57BL , Puntos Cuánticos/ultraestructura , Especies Reactivas de Oxígeno/metabolismo
9.
Chem Commun (Camb) ; 55(100): 15053-15056, 2019 Dec 12.
Artículo en Inglés | MEDLINE | ID: mdl-31777878

RESUMEN

The present study reports an aqueous synthesis approach towards off-stoichiometric copper indium sulfide quantum dots with emissions in the near-infrared spectral range. The photoluminescence properties of the dots, and in particular the appearance of dual emission at high Cu deficiency, were studied with temperature-dependent steady-state and transient photoluminescence spectroscopy.


Asunto(s)
Materiales Biocompatibles/química , Puntos Cuánticos/química , Materiales Biocompatibles/farmacología , Supervivencia Celular , Cobre/química , Células HeLa , Humanos , Indio/química , Mediciones Luminiscentes , Puntos Cuánticos/toxicidad , Temperatura , Rayos Ultravioleta
10.
Environ Sci Pollut Res Int ; 26(36): 36287-36295, 2019 Dec.
Artículo en Inglés | MEDLINE | ID: mdl-31713827

RESUMEN

Preparation of the value-added products from e-waste resources is an important step in the recycling process. The present paper aims to propose a methodology for the recovery of In from scrap LCD panel via preparation of InBO3 nanostructure. Discarded LCD panel was subjected to a recycling process through crushing, milling, and oxalic acid leaching to prepare In2(C2O4)3·6H2O. Through the leaching process, B(OH)3 from glass part (alumina borosilicate) has been leached out along with indium oxalate hydrated. Further thermal treatment on these extracted materials at 600 °C could result in the formation of InBO3 nanostructures with an average particle size of 20 nm. A multistep mechanism based on thermodynamic calculations for the recycling of the InBO3 form extracted precursors was proposed. Graphical abstract.


Asunto(s)
Residuos Electrónicos , Cristales Líquidos/química , Nanoestructuras/química , Reciclaje/métodos , Compuestos de Boro/química , Vidrio/química , Calor , Indio/química , Ácido Oxálico/química , Tamaño de la Partícula
11.
Environ Sci Technol ; 53(19): 11383-11390, 2019 Oct 01.
Artículo en Inglés | MEDLINE | ID: mdl-31483614

RESUMEN

Surface-adsorbed active species are intermediates with strong activities in heterogeneous catalytic reactions. Effective stabilization of these intermediates is crucial to improve the catalytic performance. Here, we demonstrated highly active bimetallic palladium-indium (Pd-In) nanoparticles (NPs) that can stabilize atomic H* on the surface and show efficient electrocatalytic reduction performance toward bromate. The optimal atomic ratio of Pd to In was investigated with the aim of efficient formation and strong stabilization of H*, thus facilitating the reduction and decontamination of carcinogenic bromate. Pd2In3 was the most active catalyst, with a high rate constant of 0.029 min-1, whereas the rate constant for monometallic Pd NPs was only 0.009 min-1. Density functional theory calculations suggest that Pd2In3 NPs decrease the work function and provide strong H* stabilization ability. By employing a flow-through electrode coated with Pd2In3 NPs to enhance the mass transport, the utilization of H* could be boosted and the reduction kinetics increased up to 7.5 times.


Asunto(s)
Nanopartículas , Paladio , Electrodos , Hidrógeno , Indio
12.
Molecules ; 24(18)2019 Sep 06.
Artículo en Inglés | MEDLINE | ID: mdl-31489942

RESUMEN

Strong piezoresistivity of InAsP nanowires is rationalized with atomistic simulations coupled to Density Functional Theory. With a focal interest in the case of the As(75%)-P(25%) alloy, the role of crystal phases and phosphorus atoms in strain-driven carrier conductance is discussed with a direct comparison to nanowires of a single crystal phase and a binary (InAs) alloy. Our analysis of electronic structures presents solid evidences that the strong electron conductance and its sensitivity to external tensile stress are due to the phosphorous atoms in a Wurtzite phase, and the effect of a Zincblende phase is not remarkable. With several solid connections to recent experimental studies, this work can serve as a sound framework for understanding of the unique piezoresistive characteristics of InAsP nanowires.


Asunto(s)
Arsenicales/química , Indio/química , Nanocables/química , Fósforo/química , Teoría Funcional de la Densidad , Conductividad Eléctrica , Tamaño de la Partícula , Propiedades de Superficie
13.
ACS Appl Mater Interfaces ; 11(39): 35630-35640, 2019 Oct 02.
Artículo en Inglés | MEDLINE | ID: mdl-31496235

RESUMEN

Many attempts have been made to synthesize cadmium-free quantum dots (QDs), using nontoxic materials, while preserving their unique optical properties. Despite impressive advances, gaps in knowledge of their intracellular fate, persistence, and excretion from the targeted cell or organism still exist, precluding clinical applications. In this study, we used a simple model organism (Hydra vulgaris) presenting a tissue grade of organization to determine the biodistribution of indium phosphide (InP)-based QDs by X-ray fluorescence imaging. By complementing elemental imaging with In L-edge X-ray absorption near edge structure, unique information on in situ chemical speciation was obtained. Unexpectedly, spectral profiles indicated the appearance of In-O species within the first hour post-treatment, suggesting a fast degradation of the InP QD core in vivo, induced mainly by carboxylate groups. Moreover, no significant difference in the behavior of bare core QDs and QDs capped with an inorganic Zn(Se,S) gradient shell was observed. The results paralleled those achieved by treating animals with an equivalent dose of indium salts, confirming the preferred bonding type of In3+ ions in Hydra tissues. In conclusion, by focusing on the chemical identity of indium along a 48 h long journey of QDs in Hydra, we describe a fast degradation process, in the absence of evident toxicity. These data pave the way to new paradigms to be considered in the biocompatibility assessment of QD-based biomedical applications, with greater emphasis on the dynamics of in vivo biotransformations, and suggest strategies to drive the design of future applied materials for nanotechnology-based diagnosis and therapeutics.


Asunto(s)
Hydra/metabolismo , Indio , Fosfinas , Puntos Cuánticos/química , Espectrometría por Rayos X , Animales , Indio/química , Indio/farmacocinética , Indio/farmacología , Fosfinas/química , Fosfinas/farmacocinética , Fosfinas/farmacología
14.
Int J Nanomedicine ; 14: 7065-7078, 2019.
Artículo en Inglés | MEDLINE | ID: mdl-31507320

RESUMEN

Background:  Metal-free, water-soluble and highly stable meso-tetra-(4-sulfonatophenyl) porphyrin (TPPS4) has been studied for their singlet oxygen quantum yield. However, TPPS4 suffers from inherent shortcomings. To address these, TPPS4 was conjugated to ternary copper indium sulphide/ zinc sulphide (CuInS2/ZnS) quantum dots (QDs). Purpose:  We herein report for the first time the synthesis of TPPS4-CuInS/ZnS QDs conjugate as an improved photosensitizer. Methods:  Water-soluble TPPS4 was synthesized from tetraphenylporphyrin (TPPH2) after silica-gel purification. The CuInS/ZnS QDs were synthesized by hydrothermal method at a Cu:In ratio of 1:4. The porphyrin-QDs conjugate was formed via the daggling sulfonyl bond of the porphyrin and amine bond of the QDs. The effect of pH on the optical properties of TPPS4 was evaluated. The effect of Zn:Cu + In ratio on the ZnS shell passivation was examined to reduce structural defects on the as-synthesized QDs. Results : Various spectroscopic techniques were used to confirm the successful conversion of the organic TPPH2 to water-soluble TPPS4. The singlet oxygen generation evaluation shows an improved singlet oxygen quantum yield from 0.19 for the porphyrin (TPPS4) alone to 0.69 after conjugation (CuInS/ZnS-TPPS4) with an increase in the reaction rate constant (k (s-1)).


Asunto(s)
Cobre/química , Indio/química , Porfirinas/síntesis química , Porfirinas/farmacología , Puntos Cuánticos/química , Sulfuros/síntesis química , Compuestos de Zinc/síntesis química , Concentración de Iones de Hidrógeno , Fenómenos Ópticos , Fármacos Fotosensibilizantes , Porfirinas/química , Puntos Cuánticos/ultraestructura , Oxígeno Singlete/química , Espectroscopía Infrarroja por Transformada de Fourier , Sulfuros/química , Temperatura , Compuestos de Zinc/química
15.
Radiat Res ; 192(4): 422-430, 2019 08.
Artículo en Inglés | MEDLINE | ID: mdl-31390309

RESUMEN

Photodynamic therapy (PDT) uses a combination of photosensitizers with visible light to generate reactive species and selectively kill tumor or unwanted tissue. Znln2S4 nanoparticles are widely implemented in photovoltaic device materials and photolysis water catalysts owing to their unique photoelectric properties. Whether Znln2S4 itself can be used as an effective dye in PDT is still unknown. To determine the effects and potential mechanism of Znln2S4PDT on HepG2 cell apoptosis, electron microscopic analysis was performed to monitor the apoptotic morphology of HepG2 cells upon exposure to Znln2S4-PDT. Flow cytometry was performed to measure the apoptosis rate and intracellular ROS production. Western blot and ELISA were performed to reveal the expression changes in Bax, caspase-3 and caspase-9. Data from this work suggested that cells exhibited the typical apoptotic morphology in response to Znln2S4-PDT, with high apoptotic rate. The intracellular ROS production after Znln2S4-PDT occurred in a dose-dependent manner. Moreover, Znln2S4-PDT augmented the expression levels of pro-apoptosis factors, especially, Bax, caspase-3 and caspase-9. Taken together, our novel findings, Znln2S4-PDT elicited HepG2 cell apoptosis, suggesting Znln2S4 as a promising photosensitizer candidate for cancer therapy.


Asunto(s)
Apoptosis/efectos de los fármacos , Apoptosis/efectos de la radiación , Indio/farmacología , Fotoquimioterapia , Fármacos Fotosensibilizantes/farmacología , Compuestos de Zinc/farmacología , Relación Dosis-Respuesta a Droga , Células Hep G2 , Humanos , Espacio Intracelular/efectos de los fármacos , Espacio Intracelular/metabolismo , Espacio Intracelular/efectos de la radiación , Potencial de la Membrana Mitocondrial/efectos de los fármacos , Potencial de la Membrana Mitocondrial/efectos de la radiación , Especies Reactivas de Oxígeno/metabolismo
16.
Waste Manag ; 96: 181-189, 2019 Aug 01.
Artículo en Inglés | MEDLINE | ID: mdl-31376963

RESUMEN

In this work, an environmentally-friendly leaching process for the recovery of indium (In) and tin (Sn) from LCD panel waste was investigated. Easily degradable citrates (C6H5O73-), i.e., sodium citrate and citric acid, were used as complexing agents. The morphology and composition of the species present in the LCD powder before and after the leaching processes were characterized by scanning electron microscopy (SEM) and energy dispersive spectroscopy (EDS). The concentrations of In, Sn, and iron (Fe) present in the leachate were determined by atomic absorption spectrometry (AAS). The necessary thermodynamic conditions for achieving substantial In recovery were established by using MEDUSA software. The optimal process conditions were determined experimentally by varying the initial citrate concentration as well as by using reducing or oxidizing media, respectively hydrazine (N2H4) or hydrogen peroxide (H2O2). It was found that using N2H4 in a citrate solution as a reducing agent enhances the leaching efficiency. However, high concentrations of Sn and Fe with respect to In were found in the LCD powder. Therefore, a pretreatment processes to first remove the excess of Sn and Fe, which compete with In for the citrate, was implemented. Leaching with 1 M citrate, 0.2 M N2H4, at pH = 5, using sodium hydroxide (NaOH) at solid:liquid (S:L) ratio of 20 g∙L-1, yielded a remarkably high In recovery of 98.9% after 16.6 h.


Asunto(s)
Residuos Electrónicos , Cristales Líquidos , Citratos , Ácido Cítrico , Peróxido de Hidrógeno , Indio , Reciclaje , Estaño
17.
Molecules ; 24(15)2019 Jul 31.
Artículo en Inglés | MEDLINE | ID: mdl-31370316

RESUMEN

Aluminum-doped tin oxide (SnO 2:Al) thin films were produced by an ultrasonic spray pyrolysis method. The effect of aluminum doping on structural, optical, and electrical properties of tin oxide thin films synthesized at 420 ∘C was investigated. Al doping induced a change in the morphology of tin oxide films and yielded films with smaller grain size. SnO 2 thin films undergo a structural reordering and have a texture transition from (301) to (101), and then to (002) preferred cristallographic orientation upon Al doping. The lattice parameters (a and c) decreases with Al doping, following in a first approximation Vegard's law. The optical transmission does not change in the visible region with an average transmittance value of 72-81%. Conversely, in the near infrared (NIR) region, the plasmon frequency shifts towards the IR region upon increasing Al concentration in the grown films. Nominally undoped SnO 2 have a conductivity of ∼1120 S/cm, which is at least two orders of magnitude larger than what is reported in literature. This higher conductivity is attributed to the Cl- ions in the SnCl 4.5(H 2 O) precursor, which would act as donor dopants. The introduction of Al into the SnO 2 lattice showed a decrease of the electrical conductivity of SnO 2 due to compensating hole generation. These findings will be useful for further studied tackling the tailoring of the properties of highly demanded fluorine doped tin oxide (FTO) films.


Asunto(s)
Aluminio/química , Pirólisis , Compuestos de Estaño/química , Óxido de Zinc/química , Conductividad Eléctrica , Indio/química , Espectrometría por Rayos X , Compuestos de Estaño/síntesis química , Ultrasonido
18.
Tohoku J Exp Med ; 248(3): 143-150, 2019 07.
Artículo en Inglés | MEDLINE | ID: mdl-31257311

RESUMEN

Indium is mainly used as indium-tin oxide (ITO), which has a unique character of transparency, and is a requisite in making liquid crystal displays. Pulmonary toxicity of indium compounds in humans were not recognized until the last 2 decades. Several initial human cases of indium-related lung disease, named indium lung, were reported in Japan, with their main pathologic findings being interstitial pneumonia, emphysema and cholesterol crystals-containing granulomas. In 2010, three cases with alveolar proteinosis were reported from the United States and China. As of March 2019, more than 10 cases of interstitial pneumonia-dominant indium lung have been reported. Cross-sectional studies in indium workers indicate that the serum indium concentration (sIn) is closely related to the exposure period, the extent of interstitial as well as emphysematous changes of the lung on high-resolution computed tomography (HRCT) and serum biomarkers of interstitial pneumonia, including KL-6 and surfactant protein-D (SP-D). Longitudinal studies have shown it is possible to reduce the sIn as well as the interstitial shadows on HRCT; however, emphysematous lesions increased progressively in heavily exposed workers, even after cessation of exposure. Early detection is required to prevent irreversible changes. The first case of lung cancer associated with indium lung developed in a nonsmoking ex-worker. He had been diagnosed with indium lung and stopped working in indium processing 17 years before. This suggested there is a need for appropriate screening to detect for complications of lung cancer at early stages for those with indium lung.


Asunto(s)
Indio/efectos adversos , Enfermedades Pulmonares/prevención & control , Enfermedades Pulmonares/fisiopatología , Pulmón/fisiopatología , Humanos , Pulmón/diagnóstico por imagen , Pulmón/patología , Enfermedades Pulmonares/diagnóstico por imagen , Neoplasias Pulmonares/etiología , Control Social Formal , Lugar de Trabajo
19.
Biosens Bioelectron ; 142: 111487, 2019 Oct 01.
Artículo en Inglés | MEDLINE | ID: mdl-31276907

RESUMEN

This work designed a MgIn2S4-TiONA heterojunction by growing MgIn2S4 nanoplates on TiO2 nanowire array (TiONA) for preparation of visible light photoelectrochemical (PEC) sensing platform. The heterojunction exhibited strong absorption of visible light, large surface area and high loading of biomolecules, leading to high sensing sensitivity. Using adenosine triphosphate (ATP), a marker of cell vitality, as the target model, a PEC sandwich aptasensor was constructed by immobilizing capture DNA1 on MgIn2S4 surface. In the presence of ATP and signal DNA2 with terminal ferrocene as the electron donor, a sandwiched DNA1-ATP-DNA2 complex could be formed on the PEC aptasensor. The aptasensor showed excellent performance with a wide linear range from 50 fM to 100 nM and a detection limit of 20 fM. The sensing performance including specificity, reproducibility, stability and practical use were also evaluated, showing promising application of the MgIn2S4-TiONA heterojunction in PEC biosensing.


Asunto(s)
Adenosina Trifosfato/sangre , Aptámeros de Nucleótidos/química , Técnicas Biosensibles/métodos , Nanoestructuras/química , Titanio/química , Adenosina Trifosfato/análisis , Técnicas Biosensibles/instrumentación , Técnicas Electroquímicas/instrumentación , Técnicas Electroquímicas/métodos , Diseño de Equipo , Humanos , Indio/química , Luz , Límite de Detección , Magnesio/química , Nanoestructuras/ultraestructura , Azufre/química
20.
Biosens Bioelectron ; 142: 111524, 2019 Oct 01.
Artículo en Inglés | MEDLINE | ID: mdl-31351417

RESUMEN

Herein, a highly efficient dual-quenching biosensor based on electrochemiluminescence resonance energy transfer (ECL-RET) is designed utilizing Ru-In2S3 as ECL acceptor and α-MoO3-Au as ECL donor. Compared α-MoO3-Au with pure α-MoO3, the overlapping peak area between ECL emission of Ru-In2S3 and UV-vis spectra of α-MoO3-Au is increased, indicated better quenching effect is obtained. Hollow In2S3 and α-MoO3-Au both have huge specific surface area to host a large amount of luminophores and antibodies. Moreover, HWRGWVC (H7) as specific capturer is adopted to achieve site-oriented antibody immobilization, which not only maintain antibody activity, but greatly improve the incubation process of antibodies, thus promoting the sensitivity of the biosensor. It's worth mentioning that the effect of over-potential on protein activity was proved in this work. The proposed biosensor obtained sensitive response by using PCT as a target with wide linear range from 0.0001 to 50 ng/mL and low detection limit of 12.49 fg/mL (S/N = 3), indicating its potential in the detection of biomarkers. Importantly, a novel ECL-RET pair of Ru-In2S3 (donor)/α-MoO3-Au (acceptor) is firstly developed, which opened an efficient way for highly sensitive detection of antibody in disease clinical and diagnosis analysis.


Asunto(s)
Anticuerpos Inmovilizados/química , Oro/química , Mediciones Luminiscentes/métodos , Molibdeno/química , Óxidos/química , Polipéptido alfa Relacionado con Calcitonina/sangre , Rutenio/química , Técnicas Biosensibles/métodos , Técnicas Electroquímicas/métodos , Transferencia de Energía , Humanos , Indio/química , Límite de Detección , Nanocompuestos/química , Nanocompuestos/ultraestructura
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