Your browser doesn't support javascript.
loading
Mostrar: 20 | 50 | 100
Resultados 1 - 20 de 57.654
Filtrar
1.
Estima (Online) ; 19(1): e0521, jan.-dez. 2021.
Artículo en Portugués | BDENF - Enfermería | ID: biblio-1178332

RESUMEN

Objetivo:relatar o caso de um paciente crítico com COVID-19 e mostrar os principais achados relacionados à lesão considerada Acute skin failure (ASF), bem como realizar seu diagnóstico diferencial com lesão por pressão (LP) evitável. Método: estudo observacional do tipo relato de caso, desenvolvido em um hospital de São Paulo, na unidade de terapia intensiva (UTI) exclusiva a pessoas diagnosticadas com COVID-19. Os dados foram coletados de um único paciente, entre os meses de março e setembro de 2020. Resultados: paciente com complicações da COVID-19 evoluiu com lesão de pele, inicialmente definida como LP e posteriormente reclassificada como ASF. Os seguintes achados corroboraram o diagnóstico: ventilação mecânica invasiva prolongada, insuficiências respiratória, renal e cardíaca e sepse de foco respiratório. Além disso, outros fatores agravantes, como o uso de droga vasoativa, instabilidade hemodinâmica com intolerância ao mínimo reposicionamento, jejum prolongado e coagulopatia intravascular disseminada associada à infecção pelo coronavírus. Conclusão: o relato mostra que existem dificuldades para o diagnóstico diferencial entre ASF e LP na prática clínica. Trata-se de conceito novo, sendo fundamental que o profissional de saúde reconheça os principais fatores associados ao aparecimento da ASF, muitos dos quais também estão relacionados ao desenvolvimento das LP, ressaltando a necessidade de análise individualizada dessas lesões, e garantia da implementação de intervenções adequadas para prevenção e tratamento.


Asunto(s)
Infecciones por Coronavirus , Úlcera por Presión , Unidades de Cuidados Intensivos , Atención de Enfermería
2.
São Paulo; SMS; 01 jul. 2021.
No convencional en Portugués | LILACS, Coleciona SUS, Sec. Munic. Saúde SP, Sec. Munic. Saúde SP | ID: biblio-1255247
3.
São Paulo; SMS; 02 jul. 2021.
No convencional en Portugués | LILACS, Coleciona SUS, Sec. Munic. Saúde SP, Sec. Munic. Saúde SP | ID: biblio-1255250
4.
São Paulo; SMS; 03 jul. 2021.
No convencional en Portugués | LILACS, Coleciona SUS, Sec. Munic. Saúde SP, Sec. Munic. Saúde SP | ID: biblio-1255253
5.
São Paulo; SMS; 04 jul. 2021.
No convencional en Portugués | LILACS, Coleciona SUS, Sec. Munic. Saúde SP, Sec. Munic. Saúde SP | ID: biblio-1255256
6.
São Paulo; SMS; 05 jul. 2021.
No convencional en Portugués | LILACS, Coleciona SUS, Sec. Munic. Saúde SP, Sec. Munic. Saúde SP | ID: biblio-1255257
7.
São Paulo; SMS; 06 jul. 2021.
No convencional en Portugués | LILACS, Coleciona SUS, Sec. Munic. Saúde SP, Sec. Munic. Saúde SP | ID: biblio-1281891
8.
São Paulo; SMS; 07 jul. 2021.
No convencional en Portugués | LILACS, Coleciona SUS, Sec. Munic. Saúde SP, Sec. Munic. Saúde SP | ID: biblio-1281893
9.
São Paulo; SMS; 08 jul. 2021.
No convencional en Portugués | LILACS, Coleciona SUS, Sec. Munic. Saúde SP, Sec. Munic. Saúde SP | ID: biblio-1281894
10.
Vet Microbiol ; 259: 109155, 2021 Aug.
Artículo en Inglés | MEDLINE | ID: mdl-34197977

RESUMEN

Turkey coronavirus (TCoV) can cause a highly contagious enteric disease in turkeys with severe economic losses in the global turkey industry. To date, no commercial vaccines are available for control of the disease. In the present study, we isolated a field strain (NC1743) of TCoV and evaluated its pathogenicity in specific-pathogen-free (SPF) turkey poults to establish a TCoV disease model. The results showed that the TCoV NC1743 isolate was pathogenic to turkey poults with a minimal infectious dose at 106 EID50/bird. About 50 % of one-day-old SPF turkeys infected with the virus's minimal infectious dose exhibited typical enteric disease signs and lesions from 6 days post-infection (dpi) to the end of the experiment (21 dpi). In contrast, fewer than 20 % of older turkeys (1- or 2-week-old) infected with the same amount of TCoV displayed enteric disease signs, which disappeared after 15-18 dpi. Although all infected turkeys, regardless of age, shed TCoV, the older turkeys shed less virus than the younger birds, and 50 % of the 2-week-old birds even cleared the virus at 21 dpi. Furthermore, the viral infection caused day-old turkeys more body-weight-gain reduction than older birds. The overall data demonstrated that the TCoV NC1743 isolate is a highly pathogenic strain and younger turkeys are more susceptible to TCoV infection than older birds. Thus, one-day-old turkeys infected with the minimal infectious dose of TCoV NC1743 could be used as a TCoV disease model to study the disease pathogenesis, and the TCoV NC1743 strain could be used as a challenge virus to evaluate a vaccine protective efficacy.


Asunto(s)
Infecciones por Coronavirus/veterinaria , Coronavirus del Pavo/patogenicidad , Enfermedades de las Aves de Corral/prevención & control , Pavos/virología , Animales , Anticuerpos Antivirales/sangre , Infecciones por Coronavirus/sangre , Infecciones por Coronavirus/prevención & control , Infecciones por Coronavirus/virología , Coronavirus del Pavo/clasificación , Modelos Animales de Enfermedad , Enfermedades de las Aves de Corral/sangre , Enfermedades de las Aves de Corral/virología , Organismos Libres de Patógenos Específicos
11.
Viruses ; 13(6)2021 06 04.
Artículo en Inglés | MEDLINE | ID: mdl-34199933

RESUMEN

Bovine coronavirus (BCoV) is the causative agent of winter dysentery (WD). In adult dairy cattle, WD is characterized by hemorrhagic diarrhea and a reduction in milk production. Therefore, WD leads to significant economic losses in dairy farms. In this study, we aimed to isolate and characterize local BCoV strains. BCoV positive samples, collected during 2017-2021, were used to amplify and sequence the S1 domain of S glycoprotein and the full hemagglutinin esterase gene. Based on our molecular analysis, local strains belong to different genetic variants circulating in dairy farms in Israel. Phylogenetic analysis revealed that all local strains clustered together and in proximity to other BCoV circulating in the area. Additionally, we found that local strains are genetically distant from the reference enteric strain Mebus. To our knowledge, this is the first report providing molecular data on BCoV circulating in Israel.


Asunto(s)
Infecciones por Coronavirus/epidemiología , Infecciones por Coronavirus/veterinaria , Coronavirus Bovino/genética , Disentería/veterinaria , Filogenia , Animales , Antígenos Virales/genética , Bovinos , Enfermedades de los Bovinos/epidemiología , Enfermedades de los Bovinos/virología , Coronavirus Bovino/clasificación , Coronavirus Bovino/aislamiento & purificación , Industria Lechera , Disentería/virología , Heces/virología , Femenino , Variación Genética , Israel/epidemiología , Análisis de Secuencia de ADN
12.
BMJ Open ; 11(7): e051821, 2021 07 16.
Artículo en Inglés | MEDLINE | ID: mdl-34272226

RESUMEN

OBJECTIVE: To compare results reporting and the presence of spin in COVID-19 study preprints with their finalised journal publications. DESIGN: Cross-sectional study. SETTING: International medical literature. PARTICIPANTS: Preprints and final journal publications of 67 interventional and observational studies of COVID-19 treatment or prevention from the Cochrane COVID-19 Study Register published between 1 March 2020 and 30 October 2020. MAIN OUTCOME MEASURES: Study characteristics and discrepancies in (1) results reporting (number of outcomes, outcome descriptor, measure, metric, assessment time point, data reported, reported statistical significance of result, type of statistical analysis, subgroup analyses (if any), whether outcome was identified as primary or secondary) and (2) spin (reporting practices that distort the interpretation of results so they are viewed more favourably). RESULTS: Of 67 included studies, 23 (34%) had no discrepancies in results reporting between preprints and journal publications. Fifteen (22%) studies had at least one outcome that was included in the journal publication, but not the preprint; eight (12%) had at least one outcome that was reported in the preprint only. For outcomes that were reported in both preprints and journals, common discrepancies were differences in numerical values and statistical significance, additional statistical tests and subgroup analyses and longer follow-up times for outcome assessment in journal publications.At least one instance of spin occurred in both preprints and journals in 23/67 (34%) studies, the preprint only in 5 (7%), and the journal publications only in 2 (3%). Spin was removed between the preprint and journal publication in 5/67 (7%) studies; but added in 1/67 (1%) study. CONCLUSIONS: The COVID-19 preprints and their subsequent journal publications were largely similar in reporting of study characteristics, outcomes and spin. All COVID-19 studies published as preprints and journal publications should be critically evaluated for discrepancies and spin.


Asunto(s)
COVID-19 , Infecciones por Coronavirus , COVID-19/tratamiento farmacológico , Estudios Transversales , Humanos , SARS-CoV-2
13.
Ann Palliat Med ; 10(6): 6661-6668, 2021 Jun.
Artículo en Inglés | MEDLINE | ID: mdl-34237970

RESUMEN

BACKGROUND: Novel coronavirus disease 2019 (COVID-19) is a serious infectious respiratory disease widespread worldwide. Nurses are the front-line staff in contact with infected patients and play a key role in treating patients and controlling the epidemic. The purpose of this study was to share our nursing team's experience in the treatment of COVID-19 and provide clinical guidance. METHODS: Detail nursing system arrangement was laid down: (I) reasonable division of ward channel was built; (II) effectively arranged human nursing resources and establishing special groups, including Training group, Critical patients nursing group, Quality control group, Epidemic preventive measures group, and Logistics support group; (III) optimize nursing workflow and establish various rules and regulations; (IV) scientific scheduling and humanized management; (V) pay attention to psychological support and adopt humanized management. The pre-job preparation, treatment results, and medical staff infection number were recorded. RESULTS: Fifty-four intensive care nurses all passed the training with an average score of 99.75±0.13. One patient was dead, and 22 patients were discharged smoothly. The average length of stay was 9.12 days. The medical staff was not infected. CONCLUSIONS: The treatment center was set up and functioning rapidly, safely, and orderly by implementing an emergency management strategy. The goal of a high rescue rate, low mortality, and no medical staff infection was achieved. This nursing system could be applied in COVID-19 patient treatment.


Asunto(s)
COVID-19 , Infecciones por Coronavirus , COVID-19/tratamiento farmacológico , Humanos , SARS-CoV-2 , Flujo de Trabajo
14.
Medicina (Kaunas) ; 57(6)2021 Jun 11.
Artículo en Inglés | MEDLINE | ID: mdl-34208136

RESUMEN

Coronavirus disease 2019 (COVID-19) is a rapidly spreading contagious infectious disease caused by the pathogen severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), that primarily affects the respiratory tract as well as the central nervous system (CNS). SARS-CoV-2 infection occurs through the interaction of the viral protein Spike with the angiotensin II receptor (ACE 2), leading to an increase of angiotensin II and activation of nicotinamide adenine dinucleotide phosphate oxidase2 (NOX2), resulting in the release of both reactive oxygen species (ROS) and inflammatory molecules. The purpose of the review is to explain that SARS-CoV-2 infection can determine neuroinflammation that induces NOX2 activation in microglia. To better understand the role of NOX2 in inflammation, an overview of its involvement in neurodegenerative diseases (NDs) such as Parkinson's disease (PD), Alzheimer's disease (AD), and amyotrophic lateral sclerosis (ALS) is provided. To write this manuscript, we performed a PubMed search to evaluate the possible relationship of SARS-CoV-2 infection in NOX2 activation in microglia, as well as the role of NOX2 in NDs. Several studies highlighted that NOX2 activation in microglia amplifies neuroinflammation. To date, there is no clinical treatment capable of counteracting its activation, however, NOX2 could be a promising pharmaceutical target useful for both the treatment and prevention of NDs and COVID-19 treatment.


Asunto(s)
COVID-19 , Infecciones por Coronavirus , Enfermedades Neurodegenerativas , COVID-19/tratamiento farmacológico , Humanos , SARS-CoV-2
16.
Viruses ; 13(7)2021 06 29.
Artículo en Inglés | MEDLINE | ID: mdl-34209881

RESUMEN

The viral family Coronaviridae comprises four genera, termed Alpha-, Beta-, Gamma-, and Deltacoronavirus. Recombination events have been described in many coronaviruses infecting humans and other animals. However, formal analysis of the recombination patterns, both in terms of the involved genome regions and the extent of genetic divergence between partners, are scarce. Common methods of recombination detection based on phylogenetic incongruences (e.g., a phylogenetic compatibility matrix) may fail in cases where too many events diminish the phylogenetic signal. Thus, an approach comparing genetic distances in distinct genome regions (pairwise distance deviation matrix) was set up. In alpha, beta, and delta-coronaviruses, a low incidence of recombination between closely related viruses was evident in all genome regions, but it was more extensive between the spike gene and other genome regions. In contrast, avian gammacoronaviruses recombined extensively and exist as a global cloud of genes with poorly corresponding genetic distances in different parts of the genome. Spike, but not other structural proteins, was most commonly exchanged between coronaviruses. Recombination patterns differed between coronavirus genera and corresponded to the modular structure of the spike: recombination traces were more pronounced between spike domains (N-terminal and C-terminal parts of S1 and S2) than within domains. The variability of possible recombination events and their uneven distribution over the genome suggest that compatibility of genes, rather than mechanistic or ecological limitations, shapes recombination patterns in coronaviruses.


Asunto(s)
Coronavirus/clasificación , Coronavirus/genética , Evolución Molecular , Variación Genética , Genoma Viral , Recombinación Genética , Animales , Aves/virología , Infecciones por Coronavirus/virología , Filogenia , Proteínas Virales/genética
17.
Washington, D.C.; PAHO; 2021-07-16. (PAHO/IMS/EIH/COVID-19/21-019).
No convencional en Inglés | PAHO-IRIS | ID: phr-52719

RESUMEN

The vast amount of data generated by clinical studies of potential therapeutic options for COVID-19 presents important challenges. The new data must be interpreted quickly so that prescribers can make optimal treatment decisions with as little harm to patients as possible, and so that medicines manufacturers can scale up production rapidly and bolster their supply chains. Rapid interpretation of fresh data will save lives by ensuring that successful drugs can be administered to as many patients as possible as quickly as possible. This publication, the 23rd edition of the database of evidence on potential therapeutic options for COVID-19, examines 129 therapeutic options. This information will help investigators, policymakers, and prescribers navigate the flood of relevant data to ensure that management of COVID-19, at both individual and population levels, is based on the best available knowledge. This resource will be continually updated as more research is released into the public space.


Asunto(s)
COVID-19 , Coronavirus , Infecciones por Coronavirus , Betacoronavirus , Pandemias , Medicina de Emergencia Basada en la Evidencia
18.
Washington, D.C.; PAHO; 2021-07-26. (FPL/CLAP/COVID-19/21-0034).
No convencional en Inglés | PAHO-IRIS | ID: phr3-54546

RESUMEN

The COVID-19 pandemic disrupted the provision of essential reproductive, maternal, newborn, and child health services, with impacts on maternal, newborn, and child mortality and fertility. This publication presents policymakers with a quantitative and qualitative analysis of the impacts of the COVID-19 pandemic on scenarios for women’s, newborns’, children’s, and adolescents’ health in the Americas. The quantitative analysis estimates the indirect impact of the pandemic on service coverage and shows that only a portion of women, newborns, and children will receive essential services unless there are focused efforts to minimize additional indirect impacts and to accelerate recovery of coverage of this care. The qualitative analysis examines the challenges that countries have faced in attempting to ensure continuity of care in the context of the COVID-19 pandemic and presents the strengths, challenges, and lessons learned from countries to ensure the maintenance of health services for these groups.


Asunto(s)
COVID-19 , Infecciones por Coronavirus , Coronavirus , Salud Materna , Recién Nacido , Embarazo , Salud del Niño , Salud de la Mujer , Adolescente , Salud del Adolescente , Pandemias , Mortalidad , Américas
19.
Lima; Perú. Ministerio de Salud; 20210700. 29 p.
Monografía en Español | MINSAPERÚ | ID: biblio-1281134

RESUMEN

El documento contiene los criterios técnicos y operativos para el manejo ambulatorio de personas afectadas por la COVID-19 en el Perú.


Asunto(s)
Pacientes , Infecciones por Coronavirus , Atención Ambulatoria , COVID-19 , Personas
20.
Lima; Perú. Ministerio de Salud; 20210700. 33 p. tab.
Monografía en Español | LILACS, MINSAPERÚ | ID: biblio-1087618

RESUMEN

El documento contiene los lineamientos y procedimientos para la vigilancia epidemiológica del COVID-19 en el país. Esta Directiva, deroga a la R.M. Nº 905-2020-MINSA.


Asunto(s)
Control de Enfermedades Transmisibles , Guías como Asunto , Infecciones por Coronavirus , Coronavirus , Servicios de Vigilancia Epidemiológica , Monitoreo Epidemiológico
SELECCIÓN DE REFERENCIAS
DETALLE DE LA BÚSQUEDA
...