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3.
Viruses ; 13(6)2021 06 04.
Artículo en Inglés | MEDLINE | ID: mdl-34199933

RESUMEN

Bovine coronavirus (BCoV) is the causative agent of winter dysentery (WD). In adult dairy cattle, WD is characterized by hemorrhagic diarrhea and a reduction in milk production. Therefore, WD leads to significant economic losses in dairy farms. In this study, we aimed to isolate and characterize local BCoV strains. BCoV positive samples, collected during 2017-2021, were used to amplify and sequence the S1 domain of S glycoprotein and the full hemagglutinin esterase gene. Based on our molecular analysis, local strains belong to different genetic variants circulating in dairy farms in Israel. Phylogenetic analysis revealed that all local strains clustered together and in proximity to other BCoV circulating in the area. Additionally, we found that local strains are genetically distant from the reference enteric strain Mebus. To our knowledge, this is the first report providing molecular data on BCoV circulating in Israel.


Asunto(s)
Infecciones por Coronavirus/epidemiología , Infecciones por Coronavirus/veterinaria , Coronavirus Bovino/genética , Disentería/veterinaria , Filogenia , Animales , Antígenos Virales/genética , Bovinos , Enfermedades de los Bovinos/epidemiología , Enfermedades de los Bovinos/virología , Coronavirus Bovino/clasificación , Coronavirus Bovino/aislamiento & purificación , Industria Lechera , Disentería/virología , Heces/virología , Femenino , Variación Genética , Israel/epidemiología , Análisis de Secuencia de ADN
4.
Viruses ; 13(7)2021 06 25.
Artículo en Inglés | MEDLINE | ID: mdl-34201926

RESUMEN

The SARS-CoV-2 coronavirus is the focus of attention as it has caused more than three million human deaths globally. This and other coronaviruses, such as MERS-CoV, have been suggested to be related to coronaviruses that are hosted in bats. This work shows, through a bibliographic review, the frequency of detection of coronavirus in bats species of the Americas. The presence of coronavirus in bats has been examined in 25 investigations in 11 countries of the Americas between 2007 and 2020. Coronaviruses have been explored in 9371 individuals from 160 species of bats, and 187 coronavirus sequences have been deposited in GenBank distributed in 43 species of bats. While 91% of the coronaviruses sequences identified infect a single species of bat, the remainder show a change of host, dominating the intragenera change. So far, only Mex-CoV-6 is related to MERS-CoV, a coronavirus pathogenic for humans, so further coronavirus research effort in yet unexplored bat species is warranted.


Asunto(s)
Quirópteros/virología , Infecciones por Coronavirus/epidemiología , Infecciones por Coronavirus/veterinaria , Coronavirus/clasificación , Coronavirus/genética , Américas/epidemiología , Animales , COVID-19/epidemiología , Coronavirus/aislamiento & purificación , Infecciones por Coronavirus/virología , Humanos , Coronavirus del Síndrome Respiratorio de Oriente Medio/genética , Coronavirus del Síndrome Respiratorio de Oriente Medio/aislamiento & purificación , Filogenia , SARS-CoV-2/genética , SARS-CoV-2/aislamiento & purificación
5.
Recurso de Internet en Portugués | LIS - Localizador de Información en Salud | ID: lis-48247

RESUMEN

Site Institucional da Pfizer - No combate ao Coronavírus, navegue no site saiba mais sobre a vacina PFIZER BioNTech , sobre as doenças crônicas na pandemia, dicas de produtividade com saúde, saúde mental na pandemia, cancer na pandemia e muito mais...


Asunto(s)
Redes de Comunicación de Computadores , Coronavirus , Infecciones por Coronavirus/epidemiología , Vacunas
6.
Nefrología (Madrid) ; 41(3): 329-336, mayo.-jun. 2021. tab
Artículo en Español | IBECS | ID: ibc-196539

RESUMEN

INTRODUCCIÓN: La enfermedad por coronavirus 2019 (COVID-19) es una infección viral causada por un nuevo coronavirus que está afectando a todo el mundo. Hay estudios previos de pacientes en hemodiálisis en centro, pero hay pocos datos sobre población en diálisis domiciliaria. Nuestro objetivo es estudiar la incidencia y evolución de la COVID-19 en una unidad de diálisis domiciliaria (UDD) durante el pico de la pandemia. MÉTODOS: Estudio observacional y retrospectivo que incluye todos los pacientes diagnosticados de COVID-19 de la UDD del Hospital Universitario La Paz (Madrid, España) entre el 10 de marzo y el 15 de mayo de 2020. Se recogieron los datos clínicos de la UDD (57 pacientes en diálisis peritoneal y 22 pacientes en hemodiálisis domiciliaria) y comparamos las características clínicas y la evolución de los pacientes con o sin infección por COVID-19. RESULTADOS: Doce pacientes fueron diagnosticados de COVID-19 (9 diálisis peritoneal, 3 hemodiálisis domiciliaria). No hubo diferencias estadísticamente significativas entre las características clínicas de los pacientes con COVID-19 y el resto de la unidad. La edad media fue 62 ± 18,5 años; la mayoría eran varones (75%). Todos los pacientes menos uno necesitaron hospitalización. Diez pacientes (83%) fueron dados de alta tras una media de 16,4 ± 9,7 días de hospitalización. Dos pacientes fueron diagnosticados durante su hospitalización por otro motivo y fueron los únicos que fallecieron. Los fallecidos eran de mayor edad que los supervivientes. CONCLUSIÓN: La incidencia de COVID-19 en nuestra UDD en Madrid durante el pico de la pandemia fue alto, especialmente en los pacientes en diálisis peritoneal, sin observarse un potencial beneficio para prevenir la infección en los pacientes en diálisis domiciliaria. La edad avanzada y la transmisión nosocomial fueron los principales factores relacionados con peor pronóstico


INTRODUCTION: The 2019 coronavirus (COVID-19) is a viral infection caused by a new coronavirus that is affecting the entire world. There have been studies of patients on in-center hemodialysis, but home dialysis population data are scarce. Our objective is to study the incidence and course of COVID-19 in a home dialysis unit (HDU) at the height of the pandemic. METHODS: An observational, retrospective study enrolling all patients diagnosed with COVID-19 from the HDU of Hospital Universitario La Paz (La Paz University Hospital) (Madrid, Spain) between March 10 and May 15, 2020. We collected clinical data from the HDU (57 patients on peritoneal dialysis and 22 patients on home hemodialysis) and compared the clinical characteristics and course of patients with and without COVID-19 infection. RESULTS: Twelve patients were diagnosed with COVID-19 (9 peritoneal dialysis; 3 home hemodialysis). There were no statistically significant differences in terms of clinical characteristics between patients with COVID-19 and the rest of the unit. The mean age was 62 ± 18.5 years; most were men (75%). All patients but one required hospitalization. Ten patients (83%) were discharged following a mean of 16.4 ± 9.7 days of hospitalization. Two patients were diagnosed while hospitalized for other conditions, and these were the only patients who died. Those who died were older than those who survived. CONCLUSION: The incidence of COVID-19 in our HDU in Madrid at the height of the pandemic was high, especially in patients on peritoneal dialysis. No potential benefit for preventing the infection in patients on home dialysis was observed. Advanced age and nosocomial transmission were the main factors linked to a worse prognosis


Asunto(s)
Humanos , Masculino , Femenino , Adulto , Persona de Mediana Edad , Anciano , Anciano de 80 o más Años , Infecciones por Coronavirus/epidemiología , Hemodiálisis en el Domicilio/estadística & datos numéricos , Estudios Retrospectivos , Pandemias , Incidencia , Hospitales Universitarios/estadística & datos numéricos , Estadísticas no Paramétricas , Factores de Tiempo , Diálisis Peritoneal/estadística & datos numéricos , España/epidemiología
8.
Rev. cuba. med ; 60(2): e1638,
Artículo en Español | LILACS, CUMED | ID: biblio-1280352

RESUMEN

Introducción: Existen interrogantes sobre el daño cardiovascular que ocasiona la infección por coranavirus-2 (SARS-CoV-2), que causa la enfermedad conocida como la COVID-19, lo que motiva el interés por el tema. Objetivo: Describir las manifestaciones cardiovasculares en pacientes con infección por coronavirus-2. Método: Entre mayo y septiembre de 2020, en la Universidad de Ciencias Médicas de Guantánamo se realizó una revisión bibliográfica narrativa mediante el estudio documental de revisiones sistemáticas y artículos originales relacionados con las manifestaciones cardiovasculares de la COVID-19. La búsqueda se realizó en las bases de datos bibliográficas Pubmed, Infomed, Medline, Science Direct, y SciELO. Se utilizó el buscador Google Académico, y las palabras clave y conectores: COVID-19 AND cardiovascular disease; SARS-CoV-2 AND cardiovascular disease, y los términos en español. La extracción de datos se realizó según una planilla que resumía las preguntas de interés de acuerdo al objetivo de la revisión. Desarrollo: Se reconoce que la respuesta inflamatoria sistémica desencadenada el SARS-CoV-2 puede dañar el miocardio. Las manifestaciones cardiovasculares son frecuentes y variadas, las más comunes son la miocarditis, insuficiencia cardiaca, arritmias cardiacas y síndrome coronario agudo. Aquellos individuos con enfermedad cardiovascular tienen riesgo de descompensación, mayor riesgo de daño miocárdico por esta infección y mayor morbimortalidad. Conclusión: La pandemia COVID-19 determina un daño cardiovascular que se expresa por la presentación de miocarditis, insuficiencia cardiaca, arritmias cardiacas, síndrome coronario agudo, derrame pericárdico y taponamiento cardiaco; manifestaciones más comunes en los pacientes con antecedentes de enfermedad cardiovascular, y que desfavorecen su pronóstico(AU)


Introduction: There are questions around the cardiovascular damage caused by coranavirus-2 (SARS-CoV-2) infection, which causes the disease known as COVID-19, which motivates interest in the subject. Objective: To describe the cardiovascular manifestations in COVID-19 disease. Method: A narrative bibliographic review was carried out through the documentary study of systematic reviews and original articles related to the cardiovascular manifestations of COVID-19, from May to September 2020, at the University of Medical Sciences in Guantánamo. The search was carried out in the bibliographic databases Pubmed, Infomed, Medline, Science Direct, and SciELO. Google Academic search engine was used, and the keywords and connectors were COVID-19 AND cardiovascular disease; SARS-CoV-2 AND cardiovascular disease, and the terms in Spanish. Data extraction was carried out according to a template that summarized the questions of interest according to the objective of this review. Findings: It is recognized that the systemic inflammatory response triggered by SARS-CoV-2 can damage the myocardium. Cardiovascular manifestations are frequent and varied, the most common are myocarditis, heart failure, cardiac arrhythmias, and acute coronary syndrome. Those individuals with cardiovascular disease are at risk of decompensation, increased risk of myocardial damage from this infection, and increased morbidity and mortality. Conclusion: The COVID-19 pandemic determines cardiovascular damage that is expressed by the presentation of myocarditis, heart failure, cardiac arrhythmias, acute coronary syndrome, pericardial effusion and cardiac tamponade; most common manifestations in patients with a history of cardiovascular disease, which conditions unfavorable prognosis(AU)


Asunto(s)
Humanos , Enfermedades Cardiovasculares/etiología , Infecciones por Coronavirus/epidemiología , COVID-19/complicaciones
9.
Salvador; s.n; 3 ed., rev; jun. 2021. 32 p. ilus mapas.
Monografía en Portugués | Coleciona SUS, CONASS, SES-BA | ID: biblio-1281099

RESUMEN

A 3ª edição do Plano Estadual de Contingência para Enfrentamento do SARS-CoV-2 na Bahia, contém recomendações para o contexto atual desta emergência, conforme vem evoluindo as estratégias de enfrentamento norteadas pela OMS, MS e SESAB, com vistas a minimizar o impacto na Saúde Pública provocado pela introdução do vírus em território estadual.


Asunto(s)
Humanos , Masculino , Femenino , Infecciones por Coronavirus/diagnóstico , Infecciones por Coronavirus/prevención & control , Infecciones por Coronavirus/epidemiología , Planes de Contingencia , Pandemias , Sistema Único de Salud
10.
BMC Infect Dis ; 21(1): 585, 2021 Jun 16.
Artículo en Inglés | MEDLINE | ID: mdl-34134656

RESUMEN

BACKGROUND: Human coronaviruses are causative agents of respiratory infections with several subtypes being prevalent worldwide. They cause respiratory illnesses of varying severity and have been described to be continuously emerging but their prevalence is not well documented in Uganda. This study assessed the seroprevalence of antibodies against the previously known human coronaviruses prior 2019 in Uganda. METHODS: A total 377 serum samples collected from volunteers that showed influenza like illness in five hospital-based sentinel sites and archived were analyzed using a commercial Qualitative Human Coronavirus Antibody IgG ELISA kit. Although there is no single kit available that can detect the presence of all the circulating coronaviruses, this kit uses a nucleoprotein, aa 340-390 to coat the wells and since there is significant homology among the various human coronavirus strains with regards to the coded for proteins, there is significant cross reactivity beyond HCoV HKU-39849 2003. This gives the kit a qualitative ability to detect the presence of human coronavirus antibodies in a sample. RESULTS: The overall seroprevalence for all the sites was 87.53% with no significant difference in the seroprevalence between the Hospital based sentinel sites (p = 0.8). Of the seropositive, the age group 1-5 years had the highest percentage (46.97), followed by 6-10 years (16.67) and then above 20 (16.36). An odds ratio of 1.6 (CI 0.863-2.97, p = 0.136) showed that those volunteers below 5 years of age were more likely to be seropositive compared to those above 5 years. The seropositivity was generally high throughout the year with highest being recorded in March and the lowest in February and December. CONCLUSIONS: The seroprevalence of Human coronaviruses is alarmingly high which calls for need to identify and characterize the circulating coronavirus strains so as to guide policy on the control strategies.


Asunto(s)
Anticuerpos Antivirales/sangre , Infecciones por Coronavirus/epidemiología , Coronavirus , Inmunoglobulina G/sangre , Adolescente , Adulto , Niño , Preescolar , Reacciones Cruzadas , Ensayo de Inmunoadsorción Enzimática , Femenino , Hospitales , Humanos , Lactante , Masculino , Vigilancia de Guardia , Estudios Seroepidemiológicos , Uganda/epidemiología , Adulto Joven
11.
Sci Rep ; 11(1): 12888, 2021 06 18.
Artículo en Inglés | MEDLINE | ID: mdl-34145351

RESUMEN

The first systematic review and meta-analysis to help clinician to identify early signs and symptoms of neurological manifestation in COVID-19 positive patients which will further help in early management of patients. Present systematic review and meta-analysis aimed to discuss the prevalence of neurological involvement of the 2019-nCoV patients and assess the symptomatic trend of events as compared to the 2002 "SARS" and 2012 "MERS" pandemics. The articles were systematically screened through several search engine and databases. The articles published or in preprint were included in the study till 15th May 2020. The systematic review done as per the published literatures which included 31 cross sectional, observational studies and case reports which revealed neurological signs and symptoms in SARS-COV-2 disease. For meta-analysis, we included 09 observational and cross-sectional studies which included COVID-19 positive patients and assessed the predominance of various neurological signs and symptoms in COVID-19 patients with relation to SARS-2002 and MERS-2012. Data was analyzed by using the "MedCalc" Statistical Software version 19.2.6 and reported as pooled prevalence. Standard I2 test was used to analyze the heterogeneity. We have collected and screened about a total 2615articles, finally we have included 31articles for the systematic review and 09 for meta-analysis as per the inclusion/exclusion criteria. The analysis was made as per the prevalence rate of neurological symptoms in COVID-19 positive patients. The cumulative neurological outcome of SARS-2002 and MERS-2012 was assessed to get the trends which was further tried to correlate the events with the current pandemic. During the analysis severity and outcome of neurological manifestations range from simple headache to vague non-focal complaints to severe neurologic impairment associated with seizure or meningitis. Central and peripheral nervous system (CNS/PNS) manifestations were seen during the SARS-2002, MERS-2012 and COVID-19. However, none of the publication had primary or secondary objectives of searching neurological manifestations in the COVID-19 patients and the pathogenic mechanism which will subsequently strengthen the importance to start more prospective clinical trials. The prevalence of neurological signs and symptoms were taken as primary objective. Thereafter, the prevalence of each CNS/PNS symptoms was categorized and their prevalence studied. The selection of Bagheri et al., 2020 may be discussed because they have done the cross-sectional study with the neurological finding and correlated the data with prevalence of the COVID-19 positive patients. The proportion of patients presenting with neurological outcome and clinical/PCR positivity were done. We had searched and followed all the possible online/web source, still the data collection process may remain a limitation of work due to addition of several publications on COVID-19 every day. Due to lack of data of SARS-CoV and MERS-CoV, we have included the case reports, MERS and COVID-19 in CNS/PNS manifestations.


Asunto(s)
COVID-19/epidemiología , Infecciones por Coronavirus/epidemiología , Enfermedades del Sistema Nervioso/virología , Pandemias/estadística & datos numéricos , Síndrome Respiratorio Agudo Grave/epidemiología , Comorbilidad , Humanos , Enfermedades del Sistema Nervioso/epidemiología , Prevalencia
12.
Viruses ; 13(6)2021 05 31.
Artículo en Inglés | MEDLINE | ID: mdl-34072981

RESUMEN

Infectious bronchitis virus (IBV) was first identified in the 1930s and it imposes a major economic burden on the poultry industry. In particular, GI-19 lineage has spread globally and has evolved constantly since it was first detected in China. In this study, we analyzed S1 gene sequences from 60 IBVs isolated in South Korea. Two IBV lineages, GI-15 and GI-19, were identified in South Korea. Phylogenetic analysis suggested that there were six distinct subgroups (KM91-like, K40/09-like, and QX-like I to IV) of the South Korean GI-19 IBVs. Among them, QX-type III and IV subgroups, which are phylogenetically different from those reported in South Korea in the past, accounted for more than half of the total. Moreover, the phylogeographic analysis of the QX-like subgroups indicated at least four distinct introductions of GI-19 IBVs into South Korea during 2001-2020. The efficacy of commercialized vaccines against the recently introduced QX-like subgroups should be verified, and continuous international surveillance efforts and quarantine procedures should be enhanced to prevent the incursion of viruses.


Asunto(s)
Infecciones por Coronavirus/veterinaria , Virus de la Bronquitis Infecciosa/genética , Enfermedades de las Aves de Corral/virología , Animales , Pollos , Infecciones por Coronavirus/epidemiología , Infecciones por Coronavirus/virología , Genómica , Genotipo , Virus de la Bronquitis Infecciosa/clasificación , Virus de la Bronquitis Infecciosa/aislamiento & purificación , Filogenia , Enfermedades de las Aves de Corral/epidemiología , República de Corea/epidemiología , Análisis de Secuencia de ARN , Homología de Secuencia , Glicoproteína de la Espiga del Coronavirus/genética
13.
Emerg Infect Dis ; 27(7): 1964-1968, 2021 07.
Artículo en Inglés | MEDLINE | ID: mdl-34152977

RESUMEN

Free-roaming camels, especially those crossing national borders, pose a high risk for spreading Middle East respiratory syndrome coronavirus (MERS-CoV). To prevent outbreaks, active surveillance is necessary. We found that a high percentage of dromedaries in Tunisia are MERS-CoV seropositive (80.4%) or actively infected (19.8%), indicating extensive MERS-CoV circulation in Northern Africa.


Asunto(s)
Infecciones por Coronavirus , Coronavirus del Síndrome Respiratorio de Oriente Medio , Animales , Camelus , Infecciones por Coronavirus/epidemiología , Infecciones por Coronavirus/veterinaria , Prevalencia , Túnez/epidemiología , Zoonosis
14.
Virus Genes ; 57(4): 307-317, 2021 Aug.
Artículo en Inglés | MEDLINE | ID: mdl-34061288

RESUMEN

The Coronavirus Disease 2019 (COVID-19), a pneumonic disease caused by the SARS Coronavirus 2 (SARS-CoV-2), is the 7th Coronavirus to have successfully infected and caused an outbreak in humans. Genome comparisons have shown that previous isolates, the SARS-related coronavirus (SARSr-CoV), including the SARS-CoV are closely related, yet different in disease manifestation. Several explanations were suggested for the undetermined origin of SARS-CoV-2, in particular, bats, avian and Malayan pangolins as reservoir hosts, owing to the high genetic similarity. The general morphology and structure of all these viral isolates overlap with analogous disease symptoms such as fever, dry cough, fatigue, dyspnoea and headache, very similar to the current SARS-CoV-2. Chest CT scans for SARS-CoV-2, SARS-CoV and MERS-CoV reveal pulmonary lesions, bilateral ground-glass opacities, and segmental consolidation in the lungs, a common pathological trait. With greatly overlapping similarities among the previous coronavirus, the SARS-CoV, it becomes interesting to observe marked differences in disease severity of the SARS-CoV-2 thereby imparting it the ability to rapidly transmit, exhibit greater stability, bypass innate host defences, and increasingly adapt to their new host thereby resulting in the current pandemic. The most recent B.1.1.7, B.1.351 and P.1 variants of SARS-CoV-2, highlight the fact that changes in amino acids in the Spike protein can contribute to enhanced infection and transmission efficiency. This review covers a comparative analysis of previous coronavirus outbreaks and highlights the differences and similarities among different coronaviruses, including the most recent isolates that have evolved to become easily transmissible with higher replication efficiency in humans.


Asunto(s)
COVID-19/epidemiología , Infecciones por Coronavirus/epidemiología , SARS-CoV-2/genética , Animales , COVID-19/inmunología , COVID-19/virología , Infecciones por Coronavirus/virología , Brotes de Enfermedades , Humanos , Coronavirus del Síndrome Respiratorio de Oriente Medio/genética , Virus del SRAS/genética , SARS-CoV-2/inmunología
15.
PLoS One ; 16(6): e0253622, 2021.
Artículo en Inglés | MEDLINE | ID: mdl-34166425

RESUMEN

Porcine epidemic diarrhea virus (PEDV), a leading cause of piglet diarrhea outbreaks, poses a significant danger to the swine industry. The aim of this study was to investigate the epidemic characteristics of PEDV that was circulating in Guangdong province, one of China's major pig producing provinces. Clinical samples were collected from eight pig farms in Guangdong province between 2018 and 2019 and tested for the major porcine enteric pathogens, including PEDV, transmissible gastroenteritis virus (TGEV), Swine enteric coronavirus (SeCoV), Swine acute diarrhea syndrome coronavirus (SADS-CoV), porcine deltacoronavirus (PDCoV), and porcine rotavirus (RV). As a result, only PEDV and RV were detected at a rate of 47.0% (16/34) and 18.6% (8/34), respectively. Coinfectoin with PEDV and RV occurred at a rate of PEDV 12.5% (2/16). Subsequently, the full-length S gene sequences of 13 PEDV strains were obtained, and phylogenetic analysis suggested the presence of GII-c group PEDV strains in this region (non-S-INDEL). Two novel common amino acid insertions (55T/IG56 and 551L) and one novel glycosylation site (1199G+) were detected when the CV777 and ZJ08 vaccine strains were compared. Furthermore, intragroup recombination events in the S gene regions 51-548 and 2478-4208 were observed in the PEDV strains studied. In summary, the observations provide current information on the incidence of viral agents causing swine diarrhea in southern China and detailed the genetic characteristics and evolutionary history of the dominant PEDV field strains. Our findings will aid in the development of an updated vaccine for the prevention and control of PEDV variant strains.


Asunto(s)
Infecciones por Coronavirus/genética , Brotes de Enfermedades , Filogenia , Virus de la Diarrea Epidémica Porcina/genética , Enfermedades de los Porcinos/genética , Alphacoronavirus/genética , Animales , China/epidemiología , Infecciones por Coronavirus/epidemiología , Porcinos , Enfermedades de los Porcinos/epidemiología , Virus de la Gastroenteritis Transmisible/genética
16.
Pan Afr Med J ; 38: 244, 2021.
Artículo en Inglés | MEDLINE | ID: mdl-34104292

RESUMEN

Introduction: acute respiratory tract infections (ARIs) are responsible for significant proportions of illnesses and deaths annually. Most of ARIs are of viral etiology, with human coronaviruses (HCoVs) playing a key role. This study was conducted prior to the outbreak of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) to provide evidence about the sero-epidemiology of HCoVs in rural areas of Ghana. Methods: this was a cross-sectional study conducted as part of a large epidemiological study investigating the occurrence of respiratory viruses in 3 rural areas of Ghana; Buoyem, Kwamang and Forikrom. Serum samples were collected and tested for the presence of IgG-antibodies to three HCoVs; HCoV-229E, HCoV-OC43 and HCoV-NL63 using immunofluorescence assay. Results: of 201 subjects enrolled into the study, 97 (48.3%) were positive for all three viruses. The most prevalent virus was HCoV-229E (23%; 95% CI: 17.2 - 29.3), followed by HCoV-OC43 (17%; 95% CI: 12.4 - 23.4), then HCoV-NL63 (8%, 95% CI: 4.6 - 12.6). Subjects in Kwamang had the highest sero-prevalence for HCoV-NL63 (68.8%). human coronaviruses-229E (41.3%) and HCoV-OC43 (45.7%) were much higher in Forikrom compared to the other study areas. There was however no statistical difference between place of origin and HCoVs positivity. Although blood group O+ and B+ were most common among the recruited subjects, there was no significant association (p = 0.163) between blood group and HCoV infection. Conclusion: this study reports a 48.3% sero-prevalence of HCoVs (OC43, NL63 and 229E) among rural communities in Ghana. The findings provide useful baseline data that could inform further sero-epidemiological studies on SARS-CoV-2 in Africa.


Asunto(s)
Coronavirus Humano 229E/aislamiento & purificación , Infecciones por Coronavirus/epidemiología , Coronavirus Humano NL63/aislamiento & purificación , Coronavirus Humano OC43/aislamiento & purificación , Adulto , Infecciones por Coronavirus/virología , Estudios Transversales , Femenino , Ghana/epidemiología , Humanos , Inmunoglobulina G/sangre , Masculino , Persona de Mediana Edad , Infecciones del Sistema Respiratorio/epidemiología , Infecciones del Sistema Respiratorio/virología , Población Rural/estadística & datos numéricos , Estudios Seroepidemiológicos , Adulto Joven
17.
BMC Infect Dis ; 21(1): 577, 2021 Jun 15.
Artículo en Inglés | MEDLINE | ID: mdl-34130652

RESUMEN

BACKGROUND: During outbreaks of emerging and re-emerging infections, the lack of effective drugs and vaccines increases reliance on non-pharmacologic public health interventions and behavior change to limit human-to-human transmission. Interventions that increase the speed with which infected individuals remove themselves from the susceptible population are paramount, particularly isolation and hospitalization. Ebola virus disease (EVD), Severe Acute Respiratory Syndrome (SARS), and Middle East Respiratory Syndrome (MERS) are zoonotic viruses that have caused significant recent outbreaks with sustained human-to-human transmission. METHODS: This investigation quantified changing mean removal rates (MRR) and days from symptom onset to hospitalization (DSOH) of infected individuals from the population in seven different outbreaks of EVD, SARS, and MERS, to test for statistically significant differences in these metrics between outbreaks. RESULTS: We found that epidemic week and viral serial interval were correlated with the speed with which populations developed and maintained health behaviors in each outbreak. CONCLUSIONS: These findings highlight intrinsic population-level changes in isolation rates in multiple epidemics of three zoonotic infections with established human-to-human transmission and significant morbidity and mortality. These data are particularly useful for disease modelers seeking to forecast the spread of emerging pathogens.


Asunto(s)
Control de Enfermedades Transmisibles/métodos , Enfermedades Transmisibles Emergentes/epidemiología , Enfermedades Transmisibles Emergentes/prevención & control , Brotes de Enfermedades , Conductas Relacionadas con la Salud , Animales , Infecciones por Coronavirus/epidemiología , Infecciones por Coronavirus/prevención & control , Epidemias/prevención & control , Predicción , Fiebre Hemorrágica Ebola/epidemiología , Fiebre Hemorrágica Ebola/prevención & control , Humanos , Salud Pública , Síndrome Respiratorio Agudo Grave/epidemiología , Síndrome Respiratorio Agudo Grave/prevención & control , Zoonosis/epidemiología , Zoonosis/prevención & control
18.
Viruses ; 13(5)2021 05 18.
Artículo en Inglés | MEDLINE | ID: mdl-34070175

RESUMEN

The ongoing coronavirus disease 2019 (COVID-19) pandemic has had devastating health and socio-economic impacts. Human activities, especially at the wildlife interphase, are at the core of forces driving the emergence of new viral agents. Global surveillance activities have identified bats as the natural hosts of diverse coronaviruses, with other domestic and wildlife animal species possibly acting as intermediate or spillover hosts. The African continent is confronted by several factors that challenge prevention and response to novel disease emergences, such as high species diversity, inadequate health systems, and drastic social and ecosystem changes. We reviewed published animal coronavirus surveillance studies conducted in Africa, specifically summarizing surveillance approaches, species numbers tested, and findings. Far more surveillance has been initiated among bat populations than other wildlife and domestic animals, with nearly 26,000 bat individuals tested. Though coronaviruses have been identified from approximately 7% of the total bats tested, surveillance among other animals identified coronaviruses in less than 1%. In addition to a large undescribed diversity, sequences related to four of the seven human coronaviruses have been reported from African bats. The review highlights research gaps and the disparity in surveillance efforts between different animal groups (particularly potential spillover hosts) and concludes with proposed strategies for improved future biosurveillance.


Asunto(s)
Infecciones por Coronavirus/epidemiología , Monitoreo Epidemiológico/veterinaria , África/epidemiología , Animales , Animales Salvajes/virología , COVID-19/epidemiología , Quirópteros/virología , Coronaviridae/genética , Coronavirus/patogenicidad , Ecosistema , Variación Genética , Genoma Viral , Pandemias , Filogenia , SARS-CoV-2/patogenicidad , Glicoproteína de la Espiga del Coronavirus/genética
19.
Cir. Esp. (Ed. impr.) ; 99(5): 361-367, mayo 2021. tab
Artículo en Español | IBECS | ID: ibc-192544

RESUMEN

INTRODUCCIÓN: Durante el estado de alarma sanitaria establecido a causa de la pandemia de la COVID-19 se anularon la mayor parte de las consultas externas presenciales y se estableció una consulta telefónica para el seguimiento de pacientes coloproctológicos. El objetivo de este estudio fue analizar la eficacia de la consulta telefónica (teleconsulta) en el seguimiento de los pacientes de una unidad de coloproctología, en el contexto de la pandemia de COVID-19. MÉTODO: Estudio descriptivo prospectivo de pacientes consecutivos en un solo centro. Se clasificó el resultado de la teleconsulta como alta, visita resuelta o reprogramación y se analizó por diferentes grupos diagnósticos. RESULTADOS: Del 19 de marzo al 17 de abril de 2020 se realizó la teleconsulta de 190 pacientes. La tasa de respuesta fue del 94,2% (179). Las categorías diagnósticas de los pacientes atendidos fueron: 51 (26,9%) neoplasia colorrectal, 48 (25,3%) enfermedad proctológica, 72 (37,9%) disfunciones del suelo pélvico y 19 (10%) otras enfermedades benignas. Se pudo volver a citar a 105 (55,26%) como si hubieran venido de forma presencial. Se dio el alta a 11 (5,8%) pacientes. No se encontraron diferencias significativas entre las distintas categorías diagnósticas y la resolución de la teleconsulta. Los motivos de reprogramación se analizan en el estudio. CONCLUSIÓN: En el contexto de pandemia, la teleconsulta ha permitido resolver de forma definitiva el 61% de las visitas de seguimiento y ha evitado la reprogramación de 116 pacientes. El nuevo paradigma social y sanitario tras la pandemia requerirá un replanteamiento de nuestro modelo de atención sanitaria y, en muchos aspectos, la telemedicina puede ofrecer herramientas para ello


INTRODUCTION: During the state of alarm established in Spain due to the COVID-19 pandemic, most of the face-to-face outpatient consultations were cancelled and a telephone consultation was established to follow up coloproctological patients. The objective of this study was to analyse the efficacy of telemedicine (by telephone) in monitoring patients in a coloproctology unit, in the context of the COVID-19 pandemic. METHOD: Prospective descriptive study of consecutive patients in a single centre. The result of the teleconsultation was classified as discharge, resolved visit or reprogramming and was analysed by different diagnostic groups. RESULTS: From March 19th to April 17th, 2020, the teleconsultation of 190 patients was carried out. The response rate was 94.2% (179). The diagnostic categories of the patients attended were: 51 (26.9%) colorectal neoplasia, 48 (25.3%) proctological pathology, 72 (37.9%) pelvic floor dysfunctions and 19 (10%) other benign pathologies. 105 (55.26%) could be recited as if they had come in person. Eleven (5.8%) patients were discharged. No significant differences were found between the different diagnostic categories and the resolution of the teleconsultation. The reasons for reprogramming are analyzed in the study. CONCLUSION: In the context of a pandemic, teleconsultation has allowed 61% of follow-up visits to be definitively solved, avoiding the reprogramming of 116 patients. The new social and health paradigm after the pandemic will require a rethinking of our healthcare model, and in many aspects, telemedicine can offer tools for this


Asunto(s)
Humanos , Masculino , Femenino , Adolescente , Adulto Joven , Adulto , Persona de Mediana Edad , Anciano , Anciano de 80 o más Años , Telemedicina , Pandemias , Infecciones por Coronavirus/epidemiología , Neumonía Viral/epidemiología , Neoplasias Colorrectales/terapia , Enfermedades del Colon/terapia , Enfermedades del Recto/terapia , Estudios Prospectivos
20.
Cir. Esp. (Ed. impr.) ; 99(5): 346-353, mayo 2021. tab, mapas, graf
Artículo en Español | IBECS | ID: ibc-192546

RESUMEN

INTRODUCCIÓN: La pandemia COVID-19 ha tenido una repercusión extraordinaria sobre los hospitales españoles, que han reorganizado sus recursos para tratar a estos pacientes, limitando su capacidad de atender otras patologías frecuentes. El presente estudio analiza la repercusión sobre el tratamiento de la colelitiasis y la colecistitis aguda. MÉTODOS: Se ha realizado un estudio nacional descriptivo mediante una encuesta online voluntaria, realizada en Google Drive™, distribuida por correo electrónico desde la Asociación Española de Cirujanos (AEC) a todos los cirujanos miembros. RESULTADOS: Se han recibido 153 encuestas (una por centro). El 96,7% de ellos han suspendido las colecistectomías electivas. El tratamiento conservador de la colecistitis aguda no complicada se ha realizado en un 90% de los casos (siendo previamente del 18%) y, en las colecistitis intervenidas, el 95% ha optado por el abordaje laparoscópico. Un 49% realiza algún test preoperatorio para SARS-CoV-2, y el 57% comunica haber tenido casos de confirmación postoperatoria tras alguna intervención, con peor evolución postoperatoria en el 54%. CONCLUSIONES: Esta encuesta revela que la mayoría de los centros están siguiendo las recomendaciones de las sociedades quirúrgicas durante la pandemia por COVID-19. Sin embargo, se observan algunos datos que precisan ser tenidos en cuenta en las fases sucesivas de la pandemia


INTRODUCTION: The extraordinary impact of COVID-19 pandemic on Spanish hospitals has led to a redistribution of resources for the treatment of these patients, with a decreased capacity of care for other common diseases. The aim of the present study is to analyse how this situation has affected the treatment of cholecystitis and cholelythiasis. METHODS: It is a descriptive national study after online voluntary distribution of a specific questionnaire with Google Drive™ to members of the Spanish Association of Surgeons (AEC). RESULTS: We received 153 answers (one per hospital). Elective cholecystectomies have been cancelled in 96.7% of centres. Conservative treatment for acute cholecystitis has been selected in 90% (previously 18%), and if operated, 95% have been performed laparoscopically. Globally, only 49% perform preoperative diagnostic tests for SARS-CoV-2, and 58.5% recognize there have been cases confirmed postoperatively after other surgeries, with worse surgical outcomes in 54%. CONCLUSIONS: This survey shows that most of the Spanish centers are following the surgical societies suggestions during the pandemic. However, some data requires to be taken into account for the next phase of the pandemic


Asunto(s)
Humanos , Encuestas de Atención de la Salud , Colelitiasis/cirugía , Infecciones por Coronavirus/enzimología , Infecciones por Coronavirus/epidemiología , Neumonía Viral/epidemiología , Pandemias , Colecistostomía/estadística & datos numéricos , Enfermedad Aguda , España
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