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2.
Artículo en Inglés | MEDLINE | ID: mdl-31618373

RESUMEN

Santa Catarina is a Brazilian State that has reported the lowest prevalence of human T-cell lymphotropic viruses (HTLV-1/2) in blood donors (0.04%). Although it presents ports, airports and roads that facilitate the entrance and dissemination of new infectious agents, no information exists concerning the HTLV-1/2 infections in HIV/AIDS patients. This study searched for HTLV-1/2 antibodies in plasma samples of 625 HIV/AIDS patients from the municipality of Tubarao (Southern Santa Catarina), and disclosed 1.1% of positivity (0.48% HTLV-1, 0.48% HTLV-2 and 0.16% untypeable HTLV), and a positive correlation with the male sex (OR 4.16) and intravenous drug use (OR 35.18). Although the percentage of 1.1% appears to be low, it is 27.5 times higher than the percentage detected in blood donors. Since HTLV-1 and HTLV-2 are circulating in HIV-infected individuals in Southern Santa Catarina, and these retroviruses could cause a differently impact on the HIV/AIDS outcomes, the surveillance of HTLV-1/2 is necessary, and it could support public health policies in preventing the transmission and dissemination of these viruses in this State.


Asunto(s)
Anticuerpos Antivirales/sangre , Infecciones por VIH/epidemiología , Infecciones por HTLV-I/epidemiología , Infecciones por HTLV-II/epidemiología , Virus Linfotrópico T Tipo 1 Humano/inmunología , Virus Linfotrópico T Tipo 2 Humano/inmunología , Adolescente , Adulto , Anciano , Anciano de 80 o más Años , Brasil/epidemiología , Estudios Transversales , Monitoreo Epidemiológico , Femenino , Infecciones por VIH/complicaciones , Infecciones por HTLV-I/complicaciones , Infecciones por HTLV-I/diagnóstico , Infecciones por HTLV-II/complicaciones , Humanos , Masculino , Persona de Mediana Edad , Prevalencia , Adulto Joven
3.
Rev Soc Bras Med Trop ; 52: e20180244, 2019 Jul 18.
Artículo en Inglés | MEDLINE | ID: mdl-31340354

RESUMEN

INTRODUCTION: Apart from masking the diagnosis of AIDS in patients with HIV/AIDS, human T-cell lymphotropic virus (HTLV), when present, also increases the risk of myelopathies and neurological disease in these patients. METHODS: Disease prevalence was estimated by ELISA and confirmed by Western blot. RESULTS: The coinfection rate was 1.5% (11/720); 10 of 11 patients had HTLV-1, and the remaining one had HTLV-2. The majority were male, over 40 years old, and of pardo color (ethnicity). CONCLUSIONS: There was no association between the risk factors examined and HTLV/HIV coinfection. This is the first study to report the occurrence of HTLV-2 in Pernambuco.


Asunto(s)
Coinfección , Infecciones por VIH/complicaciones , Infecciones por HTLV-I/complicaciones , Infecciones por HTLV-II/complicaciones , Adolescente , Adulto , Western Blotting , Brasil/epidemiología , Ensayo de Inmunoadsorción Enzimática , Femenino , Infecciones por VIH/epidemiología , Infecciones por HTLV-I/epidemiología , Infecciones por HTLV-II/epidemiología , Virus Linfotrópico T Tipo 1 Humano , Virus Linfotrópico T Tipo 2 Humano , Humanos , Masculino , Persona de Mediana Edad , Prevalencia , Factores de Riesgo , Factores Socioeconómicos , Adulto Joven
4.
Rev Soc Bras Med Trop ; 52: e20180481, 2019 May 30.
Artículo en Inglés | MEDLINE | ID: mdl-31166487

RESUMEN

INTRODUCTION: Human T-cell lymphotropic virus type 1 (HTLV-1)-associated inflammatory diseases are not well understood; however, their clinical manifestations may be influenced by the host genetic background. METHODS: We genotyped 298 individuals with HTLV-1 and 380 controls for interleukin-10 (IL10) gene variants-rs3024496, rs1800871, rs1800896-and used logistic regression analysis to determine their association with clinical phenotypes. RESULTS: No association with HTLV-1 infection was observed. However, allele A of rs1800896 (1082bp upstream) was associated with protection against neurological impairment, specifically overactive bladder (OR=0.447, 95% CI 0.28-0.70, p=0.001). CONCLUSIONS: Our data suggests that IL10 regulation ameliorates neurological damage in HTLV-1 infections.


Asunto(s)
Infecciones por HTLV-I/genética , Interleucina-10/genética , Polimorfismo de Nucleótido Simple/genética , Vejiga Urinaria Hiperactiva/genética , Adolescente , Adulto , Estudios de Casos y Controles , Femenino , Genotipo , Infecciones por HTLV-I/complicaciones , Virus Linfotrópico T Tipo 1 Humano , Humanos , Masculino , Persona de Mediana Edad , Fenotipo , Vejiga Urinaria Hiperactiva/etiología , Adulto Joven
5.
PLoS Negl Trop Dis ; 13(6): e0007415, 2019 06.
Artículo en Inglés | MEDLINE | ID: mdl-31170141

RESUMEN

BACKGROUND: Strongyloides stercoralis is an intestinal nematode unique in its ability to replicate in the human host, allowing ongoing cycles of autoinfection, persisting for decades within the same host. Although usually asymptomatic, overwhelming infections can occur in Strongyloides and HTLV-1 co-infected individuals (SS/HTLV-1). Regulatory T cells (Tregs) are able to blunt specific Th2 responses necessary to control the parasite. We previously reported that peripheral blood Tregs are increased in SS/HTLV-1 and correlate with low Th2 responses. We hypothesized that Tregs are also increased at the site of infection in duodenal mucosa. METHODS: Paraffin embedded duodenal biopsies were obtained from 10 SS/HTLV-1 patients, 3 controls with non-parasitic chronic duodenitis, and 2 healthy controls. Immunohistochemistry was performed using monoclonal antibodies against human CD3, CD8, IgE and FoxP3. The number of cells were counted using a conventional light microscope. The number of CD3+, CD8+, FoxP3+ and IgE positive cells per 0.35 mm2 was measured using ImagePro Plus software comparing areas adjacent or distant from parasite material. RESULTS: In patients with SS/HTLV-1, T lymphocyte counts and CD8+ cells were lower in areas adjacent to the parasite compared to non-adjacent areas (CD3+: adjacent: 6.5 [Interquartile range (IQR: 2.8-12.3)]; non-adjacent: 24.5 [IQR: 20.9-34.4]; Mann-Whitney p = 0.0003; CD8+: adjacent: 4.5 [IQR: 2.3-11.8]; non-adjacent: 21 [IQR: 15.3-42.9]; Mann-Whitney p = 0.0011). Tregs cells in the intestines (FoxP3+ expressing cells) were increased in patients with SS/HTLV-1 compared with patients with chronic duodenitis (SS/HTLV-1: 1.5 [IQR: 0.7-2.3]; duodenitis controls: 0 [range 0-0.7]; healthy controls: 0; Mann-Whitney p = 0.034). There was also a trend towards fewer eosinophils adjacent to the parasites. Among SS/HTLV-1 patients the number of IgE expressing cells was increased for in areas not adjacent to the parasite compared to non-adjacent areas (ANOVA, p = 0.001). CONCLUSIONS: Our data shows increased Treg cell numbers localized adjacent to the parasites in the duodenum SS/HTLV-1 patients. In addition, other T lymphocytes and IgE expressing cells were decreased adjacent to the parasites, suggesting an important role for Tregs in down-regulating local parasite effector responses.


Asunto(s)
Coinfección/patología , Duodeno/patología , Infecciones por HTLV-I/patología , Inmunoglobulina E/análisis , Factores Inmunológicos/análisis , Estrongiloidiasis/patología , Linfocitos T Reguladores/inmunología , Adolescente , Adulto , Biopsia , Coinfección/complicaciones , Femenino , Expresión Génica , Infecciones por HTLV-I/complicaciones , Humanos , Inmunohistoquímica , Mucosa Intestinal/patología , Masculino , Persona de Mediana Edad , Estrongiloidiasis/complicaciones , Adulto Joven
6.
Microb Pathog ; 134: 103578, 2019 Sep.
Artículo en Inglés | MEDLINE | ID: mdl-31175973

RESUMEN

Atherosclerosis is a multifactorial life-threatening disease which an epidemiologic study in Northeastern Iran showed its association with HTLV-1 infection. Therefore, a cross-sectional study of 39 newly diagnosed subjects with angiography test in three groups including 14 coronary artery disease+HTLV-1+ (CAD+HTLV-1+), 8 CAD-HTLV-1+, and 17 CAD+HTLV-1- patients and 11 healthy subjects (CAD-HTLV-1-) were conducted. In the present study, Tax and proviral load (PVL) as HTLV-1 virulence factors, along with host chemokine receptor 1 (CCR1), and CCR2 were investigated. Real-time PCR TaqMan method was carried out for PVL measurement and HTLV-1-Tax, CCR1, and CCR2 expressions in peripheral blood mononuclear cells (PBMCs). Furthermore, the main risk factors, lipid profile, and complete blood count (CBC) were assessed. Expression of CCR1 in CAD+HTLV-1+ group was higher than CAD-HTLV-1+ (P = 0.01) and healthy subjects (P = 0.02). Expression of CCR1 in CAD+HTLV-1+ was higher in comparison with CAD+HTLV-1-group but did not meet 95% CI (P = 0.02), but meaningful at 91% CI. In addition, expression of CCR2 in CAD+HTLV-1+ subjects was higher than CAD-HTLV-1+ and CAD+HTLV-1- (P = 0.001, P = 0.005, respectively). In CAD+HTLV-1- subjects, CCR2 was higher than CAD-HTLV-1+ (P = 0.03). The mean PVL in CAD+HTLV-1+ group is more than CAD-HTLV-1+ (P = 0.041). In HTLV-1+ patients Tax had a positive correlation with cholesterol (R = 0.59, P = 0.01), LDL (R = 0.79, P = 0.004) and a negative correlation with HDL (R = -0.47, P = 0.04). These correlations were stronger in CAD+HTLV-1+. Findings showed that HTLV-1 could alter the expression of CCR2 and, less effect, on CCR1. Moreover, the strong correlation between CCR2 and HTLV-1-Tax with cholesterol, LDL and HDL showed that Tax as the main HTLV-1 virulence factor in cytokine deregulation might be had indirect effects on cholesterol, LDL, and HDL levels.


Asunto(s)
Enfermedades Cardiovasculares/etiología , Enfermedades Cardiovasculares/virología , Infecciones por HTLV-I/complicaciones , Infecciones por HTLV-I/virología , Virus Linfotrópico T Tipo 1 Humano/patogenicidad , Anciano , Aterosclerosis/epidemiología , Aterosclerosis/virología , Colesterol/sangre , HDL-Colesterol/sangre , LDL-Colesterol/sangre , Enfermedad de la Arteria Coronaria/etiología , Enfermedad de la Arteria Coronaria/virología , Estudios Transversales , Citocinas/sangre , Femenino , Infecciones por HTLV-I/epidemiología , Humanos , Irán , Leucocitos Mononucleares/virología , Masculino , Persona de Mediana Edad , Provirus , Reacción en Cadena en Tiempo Real de la Polimerasa , Receptores CCR1/sangre , Receptores CCR1/metabolismo , Receptores CCR2/sangre , Receptores CCR2/metabolismo , Factores de Riesgo , Carga Viral , Factores de Virulencia
7.
Asian Pac J Cancer Prev ; 20(6): 1909-1912, 2019 06 01.
Artículo en Inglés | MEDLINE | ID: mdl-31244317

RESUMEN

Background: Human T-cell lymphotropic virus type 1 (HTLV-1) is a retrovirus that causes adult T-cell leukemia/lymphoma (ATL), an aggressive form of T-cell malignancy. The relationship between HTLV-1 infection and cancer progression is controversial. HTLV-1 encodes oncogenic protein TAX1 and it is hypothesized that HTLV-1 infection is associated with breast cancer progression. In this study, we evaluated the relationship between HTLV-1 infection and clinicopathological factors in breast cancer patients. Methods: We retrospectively analyzed 610 patients with primary breast cancer who underwent surgical treatment without preoperative chemotherapy at Kagoshima University Hospital between January 2001 and January 2015. Results: When patients with and without HTLV-1 infection were compared, no differences in clinicopathological factors were observed, except for age. Disease-free survival and overall survival rates did not differ between groups. Conclusions: HTLV-1­positive patients were significantly older than HTLV-1­negative patients. It was supposed to be due to the fact that the HTLV-1 infection rate is decreasing. Any effect of HTLV-1 infection on breast cancer progression appears to be negligibly small.


Asunto(s)
Neoplasias de la Mama/patología , Infecciones por HTLV-I/complicaciones , Virus Linfotrópico T Tipo 1 Humano/patogenicidad , Recurrencia Local de Neoplasia/patología , Neoplasias de la Mama/epidemiología , Neoplasias de la Mama/virología , Femenino , Estudios de Seguimiento , Infecciones por HTLV-I/virología , Humanos , Incidencia , Japón/epidemiología , Metástasis Linfática , Persona de Mediana Edad , Recurrencia Local de Neoplasia/epidemiología , Recurrencia Local de Neoplasia/virología , Pronóstico , Estudios Retrospectivos
8.
Medicina (B Aires) ; 79(2): 147-149, 2019.
Artículo en Español | MEDLINE | ID: mdl-31048281

RESUMEN

Strongylodiasis is an unattended condition caused by the parasite Strongyloides stercoralis. The Strongyloides hyperinfection syndrome can develop in immunosuppressed hosts, mainly in those with depression of cellular immunity. Co-infection with human T-cell lymphotropic virus (HTLV) is a risk factor for the development of severe forms of strongyloidiasis. We present the case of a 50-year-old man with Strongyloides hyperinfection and coinfection with HTLV. The diagnosis was delayed owing to its unusual epidemiology and an initial suspicion of inflammatory bowel disease. Identification of the parasite in bronchioalveolar lavage and duodenal and colonic mucosa biopsies confirmed the diagnosis. Subcutaneous ivermectin was used as an anthelmintic treatment with an adequate therapeutic response.


Asunto(s)
Coinfección/complicaciones , Infecciones por HTLV-I/complicaciones , Estrongiloidiasis/virología , Animales , Argentina , Coinfección/tratamiento farmacológico , Coinfección/patología , Humanos , Inmunocompetencia , Masculino , Persona de Mediana Edad , Índice de Severidad de la Enfermedad , Strongyloides stercoralis/patogenicidad , Estrongiloidiasis/tratamiento farmacológico , Estrongiloidiasis/patología , Síndrome
9.
Tumori ; 105(6): NP38-NP42, 2019 Dec.
Artículo en Inglés | MEDLINE | ID: mdl-31041884

RESUMEN

BACKGROUND: Adult T-cell leukemia/lymphoma (ATLL) is an aggressive disease associated with human T-lymphotropic virus type 1 infection, with a very high prevalence in tropical areas but exceptionally rare in Europe and Western countries. CASE PRESENTATION: We describe a challenging case of ATLL in a young male patient with Brazilian origin and adopted as a child by an Italian family, presenting to our clinic with atypical T-lymphocytosis and life-threatening lung infections. CONCLUSIONS: Diagnosis of ATLL outside of endemic areas can be difficult, requiring a high index of clinical suspicion with careful evaluation of the patient's clinical history. Prognosis is affected by disease stage at presentation and degree of immunosuppression. Few effective treatments are available, although new molecular insights have highlighted the role of host immune response and immune checkpoint blockade inhibitors, given the overexpression of PD-L1 on lymphoma cells and on microenvironment cells.


Asunto(s)
Leucemia-Linfoma de Células T del Adulto/diagnóstico , Linfocitos/patología , Adulto , Biomarcadores , Médula Ósea/patología , Brasil , Terapia Combinada , Resultado Fatal , Infecciones por HTLV-I/complicaciones , Infecciones por HTLV-I/tratamiento farmacológico , Infecciones por HTLV-I/virología , Virus Linfotrópico T Tipo 1 Humano , Humanos , Inmunohistoquímica , Inmunofenotipificación , Leucemia-Linfoma de Células T del Adulto/etiología , Leucemia-Linfoma de Células T del Adulto/terapia , Linfocitos/metabolismo , Masculino
10.
PLoS Negl Trop Dis ; 13(5): e0006967, 2019 05.
Artículo en Inglés | MEDLINE | ID: mdl-31042700

RESUMEN

Several studies suggest that HTLV-1 infection may be associated with a wider spectrum of neurologic manifestations that do not meet diagnostic criteria for HAM/TSP. These conditions may later progress to HAM/TSP or constitute an intermediate clinical form, between asymptomatic HTLV-1 carriers and those with full myelopathy. Our aim was to determine the prevalence of HTLV-1-associated disease in subjects without HAM/TSP, and the relationship between these findings with HTLV-1 proviral load (PVL). METHODS: 175 HTLV-1-infected subjects were submitted to a careful neurological evaluation, during their regular follow up at the HTLV outpatient clinic of the Institute of Infectious Diseases "Emilio Ribas", São Paulo city, Brazil. Clinical evaluation and blinded standardized neurological screening were performed for all the subjects by the same neurologist (MH). RESULTS: After the neurological evaluation, 133 patients were classified as asymptomatic and 42 fulfilled the criteria for intermediate syndrome (IS). The mean age of the enrolled subjects was 46.3 years and 130 (74.3%) were females. Clinical classification shows that neurological symptoms (p<0.001), visual disorders (p = 0.001), oral conditions (p = 0.001), skin lesions (p<0.001), bladder disorders (p<0.001), and rheumatological symptoms (p = 0.001), were strongly associated to IS, except for disautonomy (p = 0.21). A multivariate analysis revealed that HTLV-1 proviral load, oral conditions, bladder disorders and rheumatological symptoms were independently associated with the IS. CONCLUSIONS: We found some early alterations in 42 patients (24%), particularly the presence of previously not acknowledged clinical and neurological symptoms, among subjects previously classified as "asymptomatic", who we reclassified as having an intermediate syndrome.


Asunto(s)
Portador Sano/virología , Infecciones por HTLV-I/complicaciones , Virus Linfotrópico T Tipo 1 Humano/fisiología , Paraparesia Espástica Tropical/diagnóstico , Provirus/fisiología , Carga Viral , Adulto , Anciano , Enfermedades Asintomáticas , Brasil , Estudios de Cohortes , Femenino , Infecciones por HTLV-I/virología , Virus Linfotrópico T Tipo 1 Humano/genética , Humanos , Masculino , Persona de Mediana Edad , Examen Neurológico , Paraparesia Espástica Tropical/etiología , Paraparesia Espástica Tropical/virología , Provirus/genética
11.
Am J Trop Med Hyg ; 100(6): 1521-1524, 2019 06.
Artículo en Inglés | MEDLINE | ID: mdl-30938283

RESUMEN

HIV coinfection with hepatitis B virus (HBV), hepatitis C virus (HCV), and human T-cell lymphotropic viruses 1 and 2 (HTLV-1 and HTLV-2) is common because of shared transmission routes. There is no published data on the prevalence of these infections in people living with HIV in Sierra Leone. We conducted a cross-sectional study of 211 HIV-positive patients aged ≥ 18 years in Freetown, Sierra Leone, in November 2017. Plasma samples were analyzed using the chemiluminescent microparticle immunoassay (Architect System, Abbott ARCHITECT Analyzer, Abbott Park, IL. The majority were female (63.5%), with median age 36 years (interquartile range [IQR]: 32-44) and median CD4 count of 396 cells/µL (IQR: 214-534). Sixty patients (28.4%) were newly diagnosed and antiretroviral therapy (ART) naive; 151 patients (71.6%) were ART experienced. The prevalence of the hepatitis B surface antigen (HBsAg), total anti-hepatitis B core antibody, and anti-HCV was 21.7%, 82.9%, and 4.3%, respectively. No cases of HTLV-1 or HTLV-2 were detected. Male gender (P = 0.004) and CD4 < 350 cells/µL (P = 0.017) were associated with the HBsAg positive status.


Asunto(s)
Infecciones por VIH/complicaciones , Infecciones por HTLV-I/complicaciones , Infecciones por HTLV-II/complicaciones , Hepatitis B/complicaciones , Hepatitis C/complicaciones , Adulto , Recuento de Linfocito CD4 , Coinfección , Femenino , Infecciones por VIH/epidemiología , Infecciones por HTLV-I/sangre , Infecciones por HTLV-I/epidemiología , Infecciones por HTLV-II/sangre , Infecciones por HTLV-II/epidemiología , Hepatitis B/sangre , Hepatitis B/epidemiología , Hepatitis C/sangre , Hepatitis C/epidemiología , Humanos , Masculino , Persona de Mediana Edad , Estudios Seroepidemiológicos , Sierra Leona/epidemiología , Adulto Joven
12.
J Immunol Res ; 2019: 6574828, 2019.
Artículo en Inglés | MEDLINE | ID: mdl-30944834

RESUMEN

The cytotoxic activities of CD8+ T cells have been considered the main defense mechanism against the human T lymphotropic virus type 1 (HTLV-1). As with CD8+ T cells, NK cells can perform cytotoxic degranulation with production of cytotoxic mediators, such as perforins and granzymes. NK cells are also responsible for antibody-dependent cellular cytotoxicity (ADCC) against infected cells, but few studies have evaluated the role of NK cells in HTLV-1 infection. The aim of this study was to characterize the subsets and measure the frequency of NK cells in HTLV-1 carriers (HC) and in patients with HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) and correlate these findings with the proviral load and development of HAM/TSP. The diagnosis of HTLV-1 infection was performed with a detection antibody against viral antigens by ELISA and confirmed by Western blot. Phenotypic characterization of NK cells was performed by flow cytometry. The frequencies of CD56+, CD56+CD3-, CD56+CD16+, and CD56dim cells were decreased in HAM/TSP patients. The frequency of CD56+CD3- cells was inversely correlated with proviral load in HC but not in HAM/TSP patients. HAM/TSP patients showed decreased frequency of CD56+ and CD56dim cells expressing CD16, the main receptor for ADCC. These data indicate that NK cells may play a key role in the control of HTLV-1 infection by preventing the progression of HC to HAM/TSP.


Asunto(s)
Portador Sano/virología , Infecciones por HTLV-I/inmunología , Células Asesinas Naturales/inmunología , Paraparesia Espástica Tropical/inmunología , Carga Viral , Adulto , Anciano , Citotoxicidad Celular Dependiente de Anticuerpos , Femenino , Citometría de Flujo , Infecciones por HTLV-I/complicaciones , Virus Linfotrópico T Tipo 1 Humano , Humanos , Células Asesinas Naturales/clasificación , Proteína 1 de la Membrana Asociada a los Lisosomas/genética , Proteína 1 de la Membrana Asociada a los Lisosomas/inmunología , Masculino , Persona de Mediana Edad , Adulto Joven
13.
Ann Pathol ; 39(1): 40-46, 2019 Feb.
Artículo en Francés | MEDLINE | ID: mdl-30578040

RESUMEN

Adult T-cell leukemia/lymphoma (ATLL) is a rare medical condition and a diagnosis that ought to be considered for patients living in an area endemic for the HTLV-1 virus (human T-lymphotrophic virus) where a T-cell lymphoproliferative diagnosis has been made. The cutaneous clinical forms may be the first manifestation of the disease. We report here an observation in a 60-year-old Senegalese woman whose skin lesions were sampled to reveal the ATLL immunophenotypic profile CD4+, CD25+, FoxP3-, and CD7-. HTLV-1 seropositivity confirmed the histopathological diagnosis, and should be corroborated by demonstration of a molecular clonal rearrangement by PCR (Polymerase Chain Reaction). This is a problem because such techniques are not always available in Africa.


Asunto(s)
Infecciones por HTLV-I/complicaciones , Leucemia-Linfoma de Células T del Adulto/virología , Neoplasias Cutáneas/virología , Enfermedad Crónica , Femenino , Humanos , Persona de Mediana Edad
14.
J Infect Dis ; 219(4): 562-567, 2019 01 29.
Artículo en Inglés | MEDLINE | ID: mdl-30307560

RESUMEN

The prevalence of human T-cell lymphotropic virus type 1 (HTLV-1) and hepatitis B virus (HBV) coinfection is high in certain Indigenous Australian populations, but its impact on HTLV-1 has not been described. We compared 2 groups of Indigenous adults infected with HTLV-1, either alone or coinfected with HBV. The 2 groups had a similar HTLV-1 proviral load, but there was a significant increase in clonal expansion of HTLV-1-infected lymphocytes in coinfected asymptomatic individuals. The degree of clonal expansion was correlated with the titer of HBV surface antigen. We conclude that HTLV-1/HBV coinfection may predispose to HTLV-1-associated malignant disease.


Asunto(s)
Coinfección/virología , Infecciones por HTLV-I/complicaciones , Infecciones por HTLV-I/virología , Hepatitis B/complicaciones , Virus Linfotrópico T Tipo 1 Humano/clasificación , Virus Linfotrópico T Tipo 1 Humano/aislamiento & purificación , Adulto , Anciano , Anciano de 80 o más Años , Australia , Femenino , Humanos , Linfocitos/virología , Masculino , Persona de Mediana Edad , Grupos de Población , Provirus/genética , Provirus/aislamiento & purificación , Carga Viral
15.
Am J Trop Med Hyg ; 100(1): 130-134, 2019 01.
Artículo en Inglés | MEDLINE | ID: mdl-30457095

RESUMEN

Central nervous system (CNS) strongyloidiasis is a known but rare form of disseminated infection. The diagnosis is often made postmortem, with only five published cases of an antemortem diagnosis. We report two fatal cases of CNS strongyloidiasis diagnosed antemortem, with Strongyloides stercoralis larvae visualized in the CNS sample in one case. Risk factors for disseminated strongyloidiasis common to both cases included origination from the Caribbean, underlying human T-lymphotropic virus-1 infection, and recent prednisone use. Both cases occurred in Canada, where the occurrence of Strongyloides is uncommon, and serve as a reminder to maintain a high index of suspicion in patients with epidemiologic or clinical risk factors for dissemination.


Asunto(s)
Sistema Nervioso Central/parasitología , Diagnóstico , Strongyloides stercoralis/aislamiento & purificación , Estrongiloidiasis/diagnóstico , Anciano , Animales , Canadá , Región del Caribe , Resultado Fatal , Femenino , Infecciones por HTLV-I/complicaciones , Humanos , Masculino , Persona de Mediana Edad , Prednisona/efectos adversos , Factores de Riesgo , Estrongiloidiasis/sangre
16.
Mod Rheumatol ; 29(5): 795-801, 2019 Sep.
Artículo en Inglés | MEDLINE | ID: mdl-30246572

RESUMEN

Objective: This study aimed to investigate the time-sequential changes of risk factors for adult T-cell leukemia (ATL) development in human T-cell leukemia virus type 1 (HTLV-1)-positive rheumatoid arthritis (RA) patients. Methods: HTLV-1 infection was screened using particle agglutination assay and confirmed via western blotting in 365 RA patients. Twenty-three HTLV-1-positive RA patients were included in the study cohort. Blood samples were obtained from these patients at each observation time point. The values of HTLV-1 proviral load (PVL) and serum soluble IL-2 receptor (sIL2-R), which are risk factors for ATL development, were measured using real-time PCR and enzyme immunoassay, respectively. Results: The study cohort comprised 79 person-years. The median HTLV-1 PVL and sIL2-R values of the HTLV-1-positive RA patients were 0.44 copies per 100 white blood cells (WBCs) and 406 U/mL, respectively. Three HTLV-1-positive RA patients showed a high PVL value. No remarkable changes were observed in the PVL and sIL2-R values during the observation period. However, one elderly HTLV-1-positive RA patient who had a high PVL value developed ATL during treatment with methotrexate and infliximab. Conclusion: A thorough clinical assessment of the risk factors for ATL development may be necessary in daily clinical practice for RA patients in HTLV-1-endemic areas in Japan.


Asunto(s)
Artritis Reumatoide/epidemiología , Infecciones por HTLV-I/epidemiología , Leucemia-Linfoma de Células T del Adulto/epidemiología , Adulto , Anciano , Artritis Reumatoide/complicaciones , Femenino , Infecciones por HTLV-I/complicaciones , Humanos , Japón , Masculino , Persona de Mediana Edad
17.
Pediatr Dermatol ; 36(1): e12-e16, 2019 Jan.
Artículo en Inglés | MEDLINE | ID: mdl-30338553

RESUMEN

Infective dermatitis (ID) associated with Human T-cell leukemia virus type-1 (HTLV-1) is a rare form of severe superinfected eczema seen mostly in the Caribbean islands and Latin America. Although rapid response to antibiotic treatment is observed, patients should be monitored for development of complications associated with this retroviral infection, including T-cell leukemia/lymphoma (ATLL) and HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP). Infective dermatitis is rarely seen in the United States and therefore may be under-recognized by physicians unfamiliar with this condition. Herein, we present an additional case report of an ID associated with HTLV-1 in an 11-year-old girl from Trinidad.


Asunto(s)
Infecciones por HTLV-I/complicaciones , Enfermedades Cutáneas Infecciosas/diagnóstico , Antibacterianos/uso terapéutico , Femenino , Glucocorticoides/uso terapéutico , Virus Linfotrópico T Tipo 1 Humano/inmunología , Humanos , Piel/patología , Enfermedades Cutáneas Infecciosas/tratamiento farmacológico , Enfermedades Cutáneas Infecciosas/virología , Trinidad y Tobago
18.
Transplant Proc ; 50(10): 3940-3942, 2018 Dec.
Artículo en Inglés | MEDLINE | ID: mdl-30577291

RESUMEN

BACKGROUND: Human T-lymphotropic virus type 1 (HTLV-1) is endemic amongst the Aborigines of the Northern Territory of Australia. HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP) has been associated with this infection. In general population, isolated neurogenic bladder dysfunction in HTLV-1-infected individuals without HAM/TSP has been reported, and the HTLV-1 proviral load has been found to be higher in such patients compared with asymptomatic carriers. In solid organ transplantation, few cases of HAM/TSP have been reported worldwide, but not an isolated neurogenic bladder. CASE: A 50-year-old indigenous women from Alice Springs with end stage renal disease secondary to diabetic nephropathy with no prior history of bladder dysfunction received a cadaveric renal allograft following which she developed recurrent urinary tract infections. The recipient was seropositive for HTLV-1 infection. HTLV-1 status of donor was not checked. Urodynamic studies revealed stress incontinence and detrusor overactivity without urethral intrinsic sphincter deficiency. She had no features of myelopathy. There was elevation of the serum and cerebrospinal fluid HTLV-1 proviral load. The magnetic resonance imaging myelogram was normal. Pyelonephritis was diagnosed based on clinical features, positive cultures, and renal allograft biopsy. Continuous suprapubic catheter drainage helped preventing further episodes of allograft pyelonephritis in spite of chronic colonization of the urinary tract. CONCLUSION: Isolated bladder dysfunction is a rare manifestation of HTLV-1 infection and is probably associated with high proviral loads. This may adversely affect renal allograft and patient outcomes.


Asunto(s)
Infecciones por HTLV-I/complicaciones , Trasplante de Riñón , Pielonefritis/virología , Vejiga Urinaria Neurogénica/virología , Australia , Femenino , Virus Linfotrópico T Tipo 1 Humano , Humanos , Fallo Renal Crónico/complicaciones , Imagen por Resonancia Magnética , Persona de Mediana Edad , Grupo de Ascendencia Oceánica , Trasplante Homólogo , Carga Viral
19.
Pan Afr Med J ; 30: 61, 2018.
Artículo en Inglés | MEDLINE | ID: mdl-30344845

RESUMEN

HIV and HTLV (Human T-ymphotropic Virus) are the only known retroviruses responsible for causing infection in humans. HTLV-1 and HIV-1 are frequent co-pathogens, however, despite its potential for accelerated progression of HIV disease and the risk of developing adult T-cell lymphoma/leukemia (ATLL), HTLV-1 is seldom considered for investigation in the HIV-1 positive individual. Severe/refractory hypercalcaemia, unresponsive to conventional calcium lowering therapy may complicate up to 70% of cases of ATLL. In addition, HTLV-1 and ATLL have both been associated with a rise in dysfunctional CD4 lymphocytes, thereby conveying a false sense of immune competence in the HIV-1 infected individual.


Asunto(s)
Infecciones por VIH/complicaciones , Infecciones por HTLV-I/complicaciones , Hipercalcemia/complicaciones , Leucemia-Linfoma de Células T del Adulto/complicaciones , Linfocitos T CD4-Positivos/inmunología , Coinfección , Progresión de la Enfermedad , Infecciones por VIH/epidemiología , Infecciones por VIH/inmunología , VIH-1/aislamiento & purificación , Infecciones por HTLV-I/epidemiología , Infecciones por HTLV-I/inmunología , Humanos , Hipercalcemia/epidemiología , Leucemia-Linfoma de Células T del Adulto/epidemiología , Leucemia-Linfoma de Células T del Adulto/inmunología
20.
J Cancer Res Ther ; 14(Supplement): S694-S700, 2018 Sep.
Artículo en Inglés | MEDLINE | ID: mdl-30249889

RESUMEN

Objective: The objective of this paper was to reveal hub pathways in primary mediastinal B-cell lymphoma (PMBL) based on multiple pathway crosstalk networks (PCNs) and give insight for its pathological mechanism. Materials and Methods: Based on gene expression data, pathway data and protein-protein interaction data, background PCN (BPCN) and tumor PCN (TPCN) of PMBL were constructed. The rank product algorithm was implemented to identify hub pathways of BPCN and TPCN. Finally, topological properties (degree, closeness, betweenness, and transitivity) of hub pathways were analyzed. Results: For BPCN, there were three hundred nodes and 42,239 edges, and the pathway pairs had great overlaps. TPCN was composed of 281 nodes and 12,700 cross-talks. A total of five hub pathways were identified, nonalcoholic fatty liver disease (NAFLD), tuberculosis, human T-lymphotropic virus type-I (HTLV-I) infection, hepatitis B, and Epstein-Barr virus infection. The topological properties for them were different from each other, further between PMBL and normal controls. Conclusion: We have identified five hub pathways for PMBL, such as NAFLD, HTLV-I infection, and Hepatitis B, which might be potential biomarkers for target therapy for PMBL.


Asunto(s)
Biomarcadores de Tumor/genética , Linfoma de Células B/genética , Neoplasias del Mediastino/genética , Mapas de Interacción de Proteínas/genética , Infecciones por Virus de Epstein-Barr/complicaciones , Infecciones por Virus de Epstein-Barr/genética , Infecciones por Virus de Epstein-Barr/virología , Regulación Neoplásica de la Expresión Génica/genética , Redes Reguladoras de Genes/genética , Infecciones por HTLV-I/complicaciones , Infecciones por HTLV-I/genética , Infecciones por HTLV-I/virología , Hepatitis B/complicaciones , Hepatitis B/genética , Hepatitis B/virología , Virus Linfotrópico T Tipo 1 Humano/patogenicidad , Humanos , Linfoma de Células B/complicaciones , Linfoma de Células B/epidemiología , Linfoma de Células B/virología , Neoplasias del Mediastino/complicaciones , Neoplasias del Mediastino/epidemiología , Neoplasias del Mediastino/virología , Enfermedad del Hígado Graso no Alcohólico/complicaciones , Enfermedad del Hígado Graso no Alcohólico/genética , Enfermedad del Hígado Graso no Alcohólico/virología , Transducción de Señal/genética , Tuberculosis/complicaciones , Tuberculosis/genética , Tuberculosis/virología
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