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2.
Health Res Policy Syst ; 19(1): 54, 2021 Apr 01.
Artículo en Inglés | MEDLINE | ID: mdl-33794906

RESUMEN

The COVID-19 pandemic has shed a spotlight on the resilience of healthcare systems, and their ability to cope efficiently and effectively with unexpected crises. If we are to learn one economic lesson from the pandemic, arguably it is the perils of an overfocus on short-term allocative efficiency at the price of lack of capacity to deal with uncertain future challenges. In normal times, building spare capacity with 'option value' into health systems may seem inefficient, the costs potentially exceeding the benefits. Yet the fatal weakness of not doing so is that this can leave health systems highly constrained when dealing with unexpected, but ultimately inevitable, shocks-such as the COVID-19 pandemic. In this article, we argue that the pandemic has highlighted the potentially enormous option value of biomedical research infrastructure. We illustrate this with reference to COVID-19 response work supported by the United Kingdom National Institute for Health Research Oxford Biomedical Research Centre. As the world deals with the fallout from the most serious economic crisis since the Great Depression, pressure will soon come to review government expenditure, including research funding. Developing a framework to fully account for option value, and understanding the public appetite to pay for it, should allow us to be better prepared for the next emerging problem.


Asunto(s)
Investigación Biomédica/economía , /prevención & control , Apoyo a la Investigación como Asunto , Humanos , Medicina Estatal/economía , Reino Unido/epidemiología
3.
Urol Clin North Am ; 48(2): 245-250, 2021 May.
Artículo en Inglés | MEDLINE | ID: mdl-33795058

RESUMEN

Clinical research is of great benefit to patients and rewarding to clinicians. Clinical research in the United States is highly regulated. There are significant penalties for violating protocols. Clinical research requires a good infrastructure in each practice.


Asunto(s)
Investigación Biomédica/normas , Protocolos Clínicos/normas , Urología/normas , Humanos , Estados Unidos
4.
Cell ; 184(6): 1402-1406, 2021 03 18.
Artículo en Inglés | MEDLINE | ID: mdl-33740444

RESUMEN

The spread of scientific misinformation is not new but rather has long posed threats to human health, environmental well-being, and the creation of a sustainable and equitable future. However, with the COVID-19 pandemic, the need to develop strategies to counteract scientific misinformation has taken on an acute urgency. Cell editor Nicole Neuman sat down with Walter Quattrociocchi and Dietram Scheufele to gain insights on how we got here and what does-and does not-work to fight the spread of scientific misinformation. Excerpts from this conversation, edited for clarity and length, are presented below, and the full conversation is available with the article online.


Asunto(s)
/uso terapéutico , /prevención & control , Comunicación , Periodismo Médico , Pandemias/prevención & control , Investigación Biomédica , Humanos , Política
6.
Mol Cell ; 81(6): 1117-1119, 2021 03 18.
Artículo en Inglés | MEDLINE | ID: mdl-33740468

RESUMEN

As part of our commitment to amplifying the voices of underrepresented scientists, we are publishing the insights and experiences of a panel of underrepresented scientists. Here they discuss ways that individuals in the scientific community can begin to recognize and overcome their own racial biases. These are the personal opinions of the authors and may not reflect the views of their institutions.


Asunto(s)
Investigación Biomédica , Relaciones Raciales , Investigadores , Femenino , Humanos , Masculino , Retratos como Asunto
7.
Mol Cell ; 81(6): 1120-1121, 2021 03 18.
Artículo en Inglés | MEDLINE | ID: mdl-33740469

RESUMEN

We talk to co-first authors Man Yu and Zhengxin Peng about their paper "Interferon- gamma induces tumor resistance to anti-PD-1 immunotherapy by promoting YAP phase separation" (in this issue of Molecular Cell), the challenges of the project, and the collaborations and support systems that were important to overcome them.


Asunto(s)
Investigación Biomédica/historia , Neoplasias , Animales , Historia del Siglo XXI , Humanos , Retratos como Asunto
8.
Mol Cell ; 81(6): 1122-1125, 2021 03 18.
Artículo en Inglés | MEDLINE | ID: mdl-33740470

RESUMEN

Here, we talk to first author Susanne Zellner about her paper, "Systematically defining selective autophagy receptor-specific cargo using autophagosome content profiling," and the challenges of finishing it during the pandemic. We also hear from collaborator Martina Schifferer and chat with corresponding author Christian Behrends about running his lab.


Asunto(s)
Investigación Biomédica/historia , Autofagosomas , Autofagia , Femenino , Historia del Siglo XXI , Humanos , Retratos como Asunto
10.
12.
Sci Transl Med ; 13(584)2021 03 10.
Artículo en Inglés | MEDLINE | ID: mdl-33692133

RESUMEN

The COVID-19 pandemic halted research operations at academic medical centers. This shutdown has adversely affected research infrastructure, the current research workforce, and the research pipeline. We discuss the impact of the pandemic on overall research operations, examine its disproportionate effect on underrepresented minority researchers, and provide concrete strategies to reverse these losses.


Asunto(s)
Centros Médicos Académicos , Selección de Profesión , Pandemias , /fisiología , Investigación Biomédica/economía , Humanos , Grupos Minoritarios , Apoyo a la Investigación como Asunto/economía
13.
Syst Biol Reprod Med ; 67(1): 3-23, 2021 Feb.
Artículo en Inglés | MEDLINE | ID: mdl-33719829

RESUMEN

The COVID-19 pandemic has led to a worldwide health emergency that has impacted 188 countries at last count. The rapid community transmission and relatively high mortality rates with COVID-19 in modern times are relatively unique features of this flu pandemic and have resulted in an unparalleled global health crisis. SARS-CoV-2, being a respiratory virus, mainly affects the lungs, but is capable of infecting other vital organs, such as brain, heart and kidney. Emerging evidence suggests that the virus also targets male and female reproductive organs that express its main receptor ACE2, although it is as yet unclear if this has any implications for human fertility. Furthermore, professional bodies have recommended discontinuing fertility services during the pandemic such that reproductive services have also been affected. Although increased safety measures have helped to mitigate the propagation of COVID-19 in a number of countries, it seems that there is no predictable timeline to containment of the virus, a goal likely to remain elusive until an effective vaccine becomes available  and widely distributed across the globe. In parallel, research on reproduction has been postponed for obvious reasons, while diagnostic tests that detect the virus or antibodies against it are of vital importance to support public health policies, such as social distancing and our obligation to wear masks in public spaces. This review aims to provide an overview of critical research and ethics issues that have been continuously emerging in the field of reproductive medicine as the COVID-19 pandemic tragically unfolds.Abbreviations: ACE2: angiotensin- converting enzyme 2; ART: Assisted reproductive technology; ASRM: American Society for Reproductive Medicine; CCR9: C-C Motif Chemokine Receptor 9; CDC: Centers for Disease Control and Prevention; COVID-19: Coronavirus disease 2019; Ct: Cycle threshold; CXCR6: C-X-C Motif Chemokine Receptor 6; ELISA: enzyme-linked immunosorbent assay; ESHRE: European Society of Human Reproduction and Embryology; ET: Embryo transfer; FSH: Follicle Stimulating Hormone; FFPE: formalin fixed paraffin embedded; FYCO1: FYVE And Coiled-Coil Domain Autophagy Adaptor 1; IFFS: International Federation of Fertility Societies; IUI: Intrauterine insemination; IVF: In vitro fertilization; LH: Luteinizing Hormone; LZTFL1: Leucine Zipper Transcription Factor Like 1; MAR: medically assisted reproduction services; MERS: Middle East Respiratory syndrome; NGS: Next Generation Sequencing; ORF: Open Reading Frame; PPE: personal protective equipment; RE: RNA Element; REDa: RNA Element Discovery algorithm; RT-PCR: Reverse=trascriptase transcriptase-polymerase chain reaction; SARS: Severe acute respiratory syndrome; SARS-CoV-2: Severe Acute Respiratory Syndrome Coronavirus 2; SLC6A20: Solute Carrier Family 6 Member 20; SMS: Single Molecule Sequencing; T: Testosterone; TMPRSS2: transmembrane serine protease 2; WHO: World Health Organization; XCR1: X-C Motif Chemokine Receptor.


Asunto(s)
Fertilidad , Interacciones Huésped-Patógeno , Reproducción , /fisiología , Animales , Investigación Biomédica , Genitales/virología , Humanos , Medicina Reproductiva/ética , Técnicas Reproductivas Asistidas , Espermatogénesis
14.
Mol Cell ; 81(5): 885-888, 2021 03 04.
Artículo en Inglés | MEDLINE | ID: mdl-33667376

RESUMEN

As part of our commitment to amplifying the voices of underrepresented scientists, we are publishing the insights and experiences of a panel of underrepresented scientists. In this segment, we asked about support systems-the types of support that are most helpful (and less helpful), how to find a supportive network, and how institutions can better support underrepresented scientists. These are the personal opinions of the authors and may not reflect the views of their institutions.


Asunto(s)
Investigación Biomédica/ética , Grupos Minoritarios/psicología , Investigadores/psicología , Adulto , Investigación Biomédica/organización & administración , Diversidad Cultural , Femenino , Humanos , Masculino , Relaciones Raciales/psicología , Apoyo Social , Estados Unidos
15.
Mol Cell ; 81(5): 889-892, 2021 03 04.
Artículo en Inglés | MEDLINE | ID: mdl-33667377

RESUMEN

We talk to Prashant Rawat and Marc Boehning, collaborators and co-first authors of "Stress-induced nuclear condensation of NELF drives global transcriptional downregulation" (this issue, previewed by Xu et al.), about their motivation for becoming scientists, the challenges they faced in the course of their project, and the importance of collaboration for scientific research.


Asunto(s)
Investigación Biomédica/organización & administración , Selección de Profesión , Mentores/educación , Transcripción Genética , Adulto , Alemania , Historia del Siglo XXI , Humanos , Masculino
16.
Mol Cell ; 81(5): 893-895, 2021 03 04.
Artículo en Inglés | MEDLINE | ID: mdl-33667378

RESUMEN

Here, we talk to first authors Kyosuke Nakamura and Georg Kustatscher, as well as co-corresponding author Anja Groth, about their paper "Proteome dynamics at broken replication forks reveal a distinct ATM-directed repair response suppressing double-strand break ubiquitination" (in this issue of Molecular Cell) and their scientific journeys until now.


Asunto(s)
Investigación Biomédica/organización & administración , Selección de Profesión , Replicación del ADN , Proteómica/tendencias , Adulto , Dinamarca , Historia del Siglo XXI , Humanos , Masculino , Mentores
17.
PLoS One ; 16(3): e0247981, 2021.
Artículo en Inglés | MEDLINE | ID: mdl-33684148

RESUMEN

Stance markers are critical linguistic devices for writers to convey their personal attitudes, judgments or assessments about the proposition of certain messages. Following Hyland's framework of stance, this study investigated the distribution of stance markers in two different genres: medical research articles (medical RA) and newspaper opinion columns (newspaper OC). The corpus constructed for the investigation includes 52 medical research articles and 175 newspaper opinion articles, which were both written in English and published from January to April in 2020 with the topic focusing on COVID-19. The findings of this study demonstrated that the occurrences of stance markers in newspaper OC were far more frequent than those in medical RA, indicating the different conventions of these two genres. Despite the significant difference in the occurrences of stance markers between the two sub-corpora, similarities of the most frequent stance markers in two genres were also highlighted. The study indicated that the topic content seems to play an important role in shaping the way of how writers construct their stance. The lack of information or evidence on the topic of COVID-19 could restrain writers from making high degree of commitment to their claims, which make them adopt a more tentative stance to qualify their statements.


Asunto(s)
Actitud , Investigación Biomédica , Lingüística , Periódicos como Asunto , Escritura , Humanos
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